Pierangelo Geppetti, laureato in medicina e Chirurgia e specializzato in Endocrinologia è dal 2002 professore Ordinario di Farmacologia Clinica presso la facoltà di Medicina dell’Università di Firenze. E' stato ricercatore confermato dal 1981 al 1998 presso l'Università di Firenze e Ferrara e succesivamente professore associato di Farmacologia presso la facoltà di Scienze dell'Università di Ferrara fino al 2002. E’ membro del Board dell’European Association for Clinical Pharmacology and Therapeutics. E’ stato presidente dell’ European Neuropeptide Club, e segretario della Società Italiana di Farmacologia, (Sezione Clinica). E’ membro membro dell’American Society for Clinical Pharmacology and Therapeutics; British Pharmacological Society; European Respiratory Society; European Neuropeptide Club; Società Italiana di Farmacologia; Società Italiana per lo Studio delle Cefalee, e del ‘IUPHAR Committee for Receptor Classification (Bradykinin receptors)’, e della ‘Task Force on Chronic Cough’ della European Respiratory Society’. E’ editor di Pain, The Journal of Headache and Pain, Fundamental and Clinical Pharmacology, Journal of Molecular Neuroscience, Cough e Molecular Pain. E’ stato Editor del British Journal of Pharmacology (1996-2001). E’ revisore di American Journal of Physiology; American Journal of Respiratory and Critical care Medicine, American Journal of Pathology; Brain Research British Journal of Pharmacology; British Journal of Clinical Pharmacology Canadian Journal of Physiology and Pharmacology; Clinical Science European Journal of Pharmacology; European Respiratory Journal Journal of Applied Physiology; Journal of Neuroscience; Life Sciences Lung; Neuroscience; Neuroscience Letters; Journal of Pharmacology and Experimental Therapeutics; Trends in Pharmacological Sciences. E’ autore di 246 lavori su riviste peer reviewed e di due libri e numerosi capitoli di libri. E’ Direttore del Centro di Ricerca sulle Cefalee Primarie dell'Università di Firenze, del Centro Cefalee dell’Università di Ferrara e del Centro di Farmacoepidemiologia e Farmacoutilizzazione dell’Università di Firenze. E’ Coordinatore del Master per Associato di Ricerca Clinica dell’Università di Firenze. E' Direttore della Struttura Organizzativa Dipartimentale di Farmacologia Clinica dell'Azienda Ospadeliero Universitaria Careggi, Firenze. I sui interessi di ricerca sono finalizzati alla comprensione dei meccanismi prodolorifici e proinfiammatori di una sottopopolazione di neuroni sensitivi primari caratterizzati da fibre di tipo A-delta o C, che producono e liberano neuropeptidi ed esprimono sulle loro membrane cellulari dei canali ionici di tipo transient receptor potential (TRP). In particolare ha contribuito alla definizione del ruolo fisiopatologico dei canali TRPV1 (attivato dalla capsaicina) e TRPA1 (attivato dalla cinnamaldeide) e dei neuropeptidi sostanza P e calcitonin gene related peptide in varie malattie umane tra cui l'emicrania e le malattie respiratorie. Dal punto di vista clinico i sui interessi di ricerca sono principalmente orientati ad aspetti farmacologici della terapia dell'emicrania e della altre cefalee primarie.
Legenda
Pierangelo Geppetti (PG) is professor of clinical pharmacology at the medical School of the University of Florence, Director of the Department of Health Sciences of the University of Florence, and Director of the Department of Research and Chief of the Clinical Unit - Headache Center and Clinical Pharmacology of the University Hospital of Careggi - Florence. PG has been or is editor of the Br J Pharmacol, Physiological Reviews, Pain, Molecular Pain, The Journal of Headache and Pain, Fundamental and Clinical Pharmacology, Journal of Molecular Neuroscience, Molecular Pain. Handbook of Experimental Pharmacology. PG has been Board member of a variety of national and international scientific societies, and is President of the Italian Society for the Study of Headaches. PG started his clinical and research activity at the Headache Centre of the Institute of Internal Medicine of the University of Florence under the guidance of Prof. Federigo Sicuteri, and spent three years (1991-1993) of research at the Division of Clinical Pharmacology and the Cardiovascular Research Institute of the University of California, San Francisco. He has been Associate Professor (1998-2002) at the University of Ferrara, where he founded the local Headache Centre. Pierangelo Geppetti (PG) is a clinician and basic scientist studying the mechanisms and treatments of chronic pain, with a special focus on migraine and related primary headaches. PG’s lab seeks to understand the role of the feed-forward pathway which entails transient receptor potential (TRP) channels in Schwann cells and their ability to generate oxidative stress to signal chronic pain in models of inflammatory, neuropathic, cancer, and migraine pain. PG’s lab and clinical unit has been and is committed to understand the underlying mechanism of the pro-migraine activity of calcitonin gene-related peptide (CGRP) and how anti-CGRP drugs ameliorate migraine and related headaches. The lab also seeks to discover new medicines for the treatment of chronic pain. Awarded an ERC-advanced grant (September 2019). PG has authored >360 articles in peer-reviewed journals (PubMed) with an H-Index of 73 and total citations >20,000 (Scopus).
Personal
Name
Pierangelo Geppetti
Birth
December 4th, 1952, Arezzo, Italy
Nationality
Italian
Professional address
Department of Health Sciences, University of Florence
Viale Piaraccini 6, 50139 Florence, Italy
Email
geppetti@unifi.it
Education
March 1978
Degree in Medicine and Surgery
1978
Internship in Internal Medicine, Santa Maria Nuova Hospital, University of Florence, Florence, Italy
1979
Internship in Paediatrics, Santa Maria Nuova Hospital, University of Florence, Florence, Italy
1979-1980
Grant from the University of Florence for training in Clinical Pharmacology in the Institute of Internal Medicine, Division of Clinical Pharmacology.
1983
Specialization in Endocrinology, University of Florence, Florence, Italy
1991-1993
Fellowship in Clinical Pharmacology, Division of Clinical Pharmacology, Department of Medicine, University of California, San Francisco
Academic Position
2016-2019
Chairman, College of Department Directors, University of Florence
Director, Department of Research, University Hospital Careggi
2013-present
Chairman, Department of Health Sciences, University of Florence
2010-present
Head, Clinical Unit Headache Centre and Clinical Pharmacology, University Hospital Careggi
2002-present
Professor of Clinical Pharmacology, University of Florence
1998-2002
Associate Professor of Pharmacology, Department of Experimental and Clinical Medicine, Section of Pharmacology, University of Ferrara
1996-1998
Assistant Professor of Pharmacology, Department of Experimental and Clinical Medicine, Section of Pharmacology, University of Ferrara
1981- 1996
Assistant Professor of Clinical Pharmacology, Department of Medicine and Clinical Pharmacology, University of Florence, Florence
Other Positions
2013 - 2015
Chairman, Ethics Committee, University Hospital Careggi
Visits or stays in research laboratories abroad
6-7, 1982
Department of Pharmacology, Oxford University, Oxford, UK
4-6, 1983
Section de Pharmacologie Immonologique, Laboratoire d'Etude des Medicaments, CEA, Gyf-sur-Yvette, France
Cardiovascular Research Institute and Department of Medicine, University of California, San Francisco, CA
Division of Clinical Pharmacology, Department of Medicine, University of California, San Francisco, CA
Grants and Clinical Trials
Major research grants as principal investigator were from NATO; NIH-Italian CNR; Italian National Research Council; Italian Ministry of Research, FIRB, PRIN; European Union; Menarini Pharmaceuticals, Italy; Dompè Pharmaceuticals, Italy; CibNovartis, Switzerland; Boehringer Mannheim, Germany; Astra-Zeneca, Sweden; Roche-Bioscience, USA; Abbott Pharmaceuticals, Italy; Sanofi-Aventis, Montpellier; Pfizer, USA; Merck, USA; Chiesi Farmaceutici, Italy; Regione Toscana - POR; Italian Institute of Technology. Major clinical trials as principal investigator, Eli Lilly, Novartis, Electrocore, Teva, Ibsa.
2019 Awarded the European Research Council Advanced Grant
Scientific Society Memberships
American Society for Clinical Pharmacology and Therapeutics; British Pharmacological Society; European Neuropeptide Club; Italian Pharmacological Society (Section of Clinical Pharmacology); European Association for Clinical Pharmacology and Therapeutics (Member of the Board); Italian Association for the study of Pain (AISD, Member of the Board); Member of the IUPHAR Committee for Receptor Classification (Bradykinin receptors).
President, Italian Society for the Study of Headaches
Editor of Scientific Journals
Physiological Reviews; Pain; Cough; Molecular Pain; Frontiers in Pain Pharmacology; Journal of Headache and Pain; Journal of Molecular Neuroscience; Journal of Occupational Medicine and Toxicology; Pain Research and Treatment; Pulmonary Pharmacology; British Journal of Pharmacology (Previous).
Reviewer for Scientific Institutions
Wellcome Trust; British Council; Swiss National Science Foundation; Dutch Asthma Foundation; European Respiratory Society; Research Foundations – Flanders; Agencie Nationale de la Recherce - France; Neurological Foundation New Zealand; Biotechnology and Biological Sciences Research Council-UK.
Publications
Original Publications and Reviews: >360 PubMed)
Total Citations: >19,000 (Scopus)
H-Index: 73 (Scopus)
Research Activity
Pierangelo Geppetti (PG) is a clinician and basic scientist studying the mechanisms and treatments of chronic pain, with a special focus on migraine and related primary headaches. PG’s lab seeks to understand the role of the feed-forward pathway which entails transient receptor potential (TRP) channels in Schwann cells and their ability to generate oxidative stress to signal chronic pain in models of inflammatory, neuropathic, cancer, and migraine pain. PG’s lab and clinical unit has been and is committed to understand the underlying mechanism of the pro-migraine activity of calcitonin gene-related peptide (CGRP) and how anti-CGRP drugs ameliorate migraine and related headaches. The lab also seeks to discover new medicines for the treatment of chronic pain.
