Personale

Recapiti

Orario di ricevimento

Italiano

Biografia

Curriculum

Interessi

Note

Pubblicazioni

Insegnamenti

English

Biography

Curriculum

Interest

Note

Maria Novella ROMANELLI

Ruolo attuale:: Professore Ordinario
SSD:: CHEM-07/A - Chimica farmaceutica
Afferenza organizzativa:: Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino (NEUROFARBA)

Recapiti

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Ulteriori Recapiti

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Maria Novella ROMANELLI

Orario di ricevimento (aggiornato al 30/08/2022)

tutti i giorni, previo appuntamento

Maria Novella ROMANELLI

Biografia

Data di nascita: 5 luglio 1957

Cittadinanza: Italiana

Stato civile: coniugata

Posizione attuale: Professore ordinario, SSD CHEM-07A

Maria Novella ROMANELLI

Curriculum

FORMAZIONE ACCADEMICA E POSIZIONI

Aprile 1982: Laurea in Chimica e Tecnologia Farmaceutiche presso l’Università di Firenze, conseguita con una tesi in chimica organica (relatore Prof. Alfredo Ricci, titolo della tesi: Prospettive sintetiche nella funzionalizzazione di lattoni saturi ed insaturi ad opera di derivati organometallici) e votazione di 110 e lode

Aprile 1983-ottobre 1984: postdoctorial fellow presso l’Università del Sussex (UK), per progetti relativi alla chimica del silicio. Supervisore: Prof. Colin Eaborn; titolo dei progetti: Sterically hindered organosilicon compounds, Novel organometallic species and reactions.

Novembre 1985-ottobre 1988: Dottorato di ricerca in Chimica del farmaco presso l’Università di Firenze. Titolo della tesi: Sintesi, configurazione assoluta e enantioselettività di antagonisti muscarinici a nucleo 1,3-ossatiolanico. Supervisore: Prof. Fulvio Gualtieri

Gennaio-novembre 1989: Borsa di studio di Tecnofarmaci (Pomezia) su un progetto relativo alla sintesi di antagonisti selettivi per i recettori colinergici.

Dicembre 1989- ottobre 1998: Ricercatore presso la Facoltà di Farmacia dell’Università di Firenze

Novembre 1998 –Ottobre 2001: Professore Associato di Chimica Farmaceutica (SSD CHIM08) presso la Facoltà di Farmacia dell’Università di Firenze

Novembre 2001 -oggi: Professore Ordinario di Chimica Farmaceutica, SSD CHEM-07A.

FORMAZIONE E RICERCA ALL'ESTERO

1986 (Luglio, Agosto) e 1987 (luglio): periodo di studio presso il Physiologisches Insitut III, Università di Düsseldorf (D) su un progetto di farmacologia molecolare. Supervisore: Prof. Raimund Mannhold

1988 (Settembre-Novembre): periodo di studio alla Royal Danish School of Pharmacy, Copenhaghen (DK), su un progetto di molecular modelling. Supervisore: Prof. Flemming Jorgensen

1993 (Luglio-Dicembre): borsa di studio CNR presso la Freie Universität, Berlin (D) su un progetto di molecular modelling. Supervisore: Prof. Hans-Dieter Höltje.

ATTIVITÀ ACCADEMICA

2007-2014: Presidente del corso di laurea in Chimica e Tecnologia Farmaceutiche, Facoltà di Farmacia (ora Scuola di Scienze della Salute Umana),

2009-2014: membro del comitato scientifico della European School of Medicinal Chemistry (Urbino) per studenti di dottorato.

2010-2013: Vice-preside della Facoltà di Farmacia dell’Università di Firenze.

2013-2018: membro della Commissione di Ateneo “Proprietà intellettuale e brevetti”, Università di Firenze.

INTERESSI DI RICERCA

Progettazione e sintesi di composti biologicamente attivi nel campo dei: Modulatori colinergici, muscarinici e nicotinici; Sostanze nootrope; Inibitori della MultiDrug Resistance dipendente dalla Glicoproteina-P; Inibitori HDAC e duali HDAC-BRD4; Modulatori dell’Anidrasi Carbonica; Modulatori di canali ionici.

SOCIETÀ SCIENTIFICHE

Membro della Società Chimica Italiana

ATTIVITÀ DI REVISIONE

Revisore per le seguenti riviste: ACS Medicinal Chemistry Letters, Bioorganic and Medicinal Chemistry, Bioorganic and Medicinal Chemistry Letters, Canadian Journal of Physiology and Pharmacology, Chirality, Current Medicinal Chemistry, European Journal of Medicinal Chemistry, European Journal of Organic Chemistry, Expert Opinion on Therapeutic Patents, Future Medicinal Chemistry, Journal fo Enzyme Inhibition and Medicinal Chemistry, Journal of Medicinal Chemistry, Letters in Organic Chemistry, Molecules, Omega, Pharmacological Reports, Synthetic Communications.

Revisore di progetti di ricerca per: Science Foundation Ireland, Fondation por la Recherche Medical (France), Fondecyt (Cile), Università di Bologna, Università di Milano.

BUBBLICAZIONI E BREVETTI

Co-inventore in 4 domande di brevetto.

Co-autore di >160 lavori e capitoli di libro.

Maria Novella ROMANELLI

Interessi

Progettazione e sintesi di composti biologicamente attivi nel campo dei:

Modulatori colinergici, muscarinici e nicotinici;

Sostanze nootrope

Inibitori della MultiDrug Resistance dipendente dalla Glicoproteina-P;

Inibitori HDAC e duali HDAC-BRD4;

Modulatori dell’Anidrasi Carbonica;

Modulatori di canali ionici.

Maria Novella ROMANELLI

Note

2007-2014: Presidente del corso di laurea in Chimica e Tecnologia Farmaceutiche

2009-2014: membro del comitato scientifico della European School of Medicinal Chemistry (Urbino) per studenti di dottorato

2010-2013: Vice-preside della Facoltà di Farmacia dell’Università di Firenze

2013-2018: membro della Commissione di Ateneo “Proprietà intellettuale e brevetti”, Università di Firenze

Maria Novella ROMANELLI

Pubblicazioni

Legenda

Contributo su rivista |

Articolo su libro |

Libro |

Contributo in atti di convegno (proceeding) |

Brevetto |

Curatela | Altro

Altro |

Tesi di Dottorato

Looschen K.; Khatri S.N.; Maulik M.; Salisbury C.; Carman A.F.; Corriveau K.; Smith C.; Manetti D.; Romanelli M.N.; Arias H.R.; Gipson C.D.; Mitra S. (2024). Novel psychoplastogen DM506 reduces cue-induced heroin-seeking and inhibits tonic GABA currents in the Prelimbic Cortex. NEUROCHEMISTRY INTERNATIONAL, vol. 178, pp. 1-10, ISSN:0197-0186 DOI

Braconi L.; Riganti C.; Parenti A.; Cecchi M.; Nocentini A.; Bartolucci G.; Menicatti M.; Contino M.; Colabufo N.A.; Manetti D.; Romanelli M.N.; Supuran C.T.; Teodori E. (2024). Dual Inhibitors of P-gp and Carbonic Anhydrase XII (hCA XII) against Tumor Multidrug Resistance with Piperazine Scaffold. MOLECULES, vol. 29, pp. 1-32, ISSN:1420-3049 DOI Accesso ONLINE all'editore

Arias H.R.; Rudin D.; Hines D.J.; Contreras A.; Gulsevin A.; Manetti D.; Anouar Y.; De Deurwaerdere P.; Meiler J.; Romanelli M.N.; Liechti M.E.; Chagraoui A. (2024). The novel non-hallucinogenic compound DM506 (3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole) induces sedative- and anxiolytic-like activity in mice by a mechanism involving 5-HT2A receptor activation. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 966, pp. 1-14, ISSN:0014-2999 DOI

Hugo R. Arias, Laura Micheli, Deborah Rudin, Ophelie Bento, Saskia Borsdorf, Clara Campi, Philippe Marin, Evgeni Ponimaskin, Dina Manetti, Maria Novella Romanelli, Carla Ghelardini, Matthias E. Liechti, Lorenzo Di Cesare Mannelli (2024). Non-hallucinogenic compounds derived from iboga alkaloids alleviate neruopathic and visceral pain in mice through a mechanism involving 5-HT2A receptor activation. BIOMEDICINE & PHARMACOTHERAPY, vol. 177, pp. 1-14, ISSN:1950-6007 DOI

Han-Shen Tae, Marcelo O. Ortells, Bassel J. Tekarli, Dina Manetti, Maria Novella Romanelli, J. Michael McIntosh, David J. Adams, and Hugo R. Arias (2023). DM506 (3-Methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole fumarate), a Novel Derivative of Ibogamine, Inhibits alpha7 and alpha9alpha10 nicotinic Acetylcholine Receptors by Different Allosteric Mechanisms. ACS CHEMICAL NEUROSCIENCE, vol. 14, pp. 2537-2547, ISSN:1948-7193 DOI

Arias, Hugo R; Tae, Han-Shen; Micheli, Laura; Yousuf, Arsalan; Manetti, Dina; Romanelli, Maria Novella; Ghelardini, Carla; Adams, David J; Di Cesare Mannelli, Lorenzo (2023). The Antinociceptive Activity of (E)-3-(thiophen-2-yl)- N -(p-tolyl)acrylamide in Mice Is Reduced by (E)-3-(furan-2-yl)- N -methyl- N -(p-tolyl)acrylamide Through Opposing Modulatory Mechanisms at the α7 Nicotinic Acetylcholine Receptor. ANESTHESIA AND ANALGESIA, vol. 137, pp. 691-701, ISSN:0003-2999 DOI

Arias, Hugo R; Pierce, Spencer R; Germann, Allison L; Xu, Sophia Q; Ortells, Marcelo O; Sakamoto, Seiji; Manetti, Dina; Romanelli, Maria Novella; Hamachi, Itaru; Akk, Gustav (2023). Chemical, Pharmacological, and Structural Characterization of Novel Acrylamide-Derived Modulators of the GABAA Receptor. MOLECULAR PHARMACOLOGY, vol. 104, pp. 115-131, ISSN:0026-895X DOI

Dina Manetti , Silvia Dei, Hugo R. Arias, Laura Braconi, Alessio Gabellini, Elisabetta Teodori, Maria Romanelli (2023). Recent advances in the discovery of Nicotinic acetylcholine receptor allosteric modulators. MOLECULES, vol. 28, pp. 1-24, ISSN:1420-3049 DOI Accesso ONLINE all'editore

Braconi L.; Dei S.; Contino M.; Riganti C.; Bartolucci G.; Manetti D.; Romanelli M.N.; Perrone M.G.; Colabufo N.A.; Guglielmo S.; Teodori E. (2023). Tetrazole and oxadiazole derivatives as bioisosteres of tariquidar and elacridar: New potent P-gp modulators acting as MDR reversers. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 259, pp. 0-0, ISSN:1768-3254 DOI Accesso ONLINE all'editore

Romanelli, Maria Novella; Braconi, Laura; Gabellini, Alessio; Manetti, Dina; Marotta, Giambattista; Teodori, Elisabetta (2023). Synthetic approaches to piperazine-containing drugs approved by FDA in the period of 2011–2023. MOLECULES, vol. 29, pp. 0-0, ISSN:1420-3049 DOI

Patberg, Marius; Oniani, Tengiz; Disse, Paul; Peischard, Stefan; Vinnenberg, Laura; Zobeiri, Mehrnoush; Romanelli, Maria N; Epping, Lisa; Wiendl, Heinz; Meuth, Sven G; Hundehege, Petra; Seebohm, Guiscard; Budde, Thomas; Junker, Anna (2023). Optimized synthesis and pharmacological evaluation of HCN channel inhibitor EC18. ARCHIV DER PHARMAZIE, pp. 0-0, ISSN:0365-6233 DOI

Braconi L.; Teodori E.; Contino M.; Riganti C.; Bartolucci G.; Manetti D.; Romanelli M.N.; Perrone M.G.; Colabufo N.A.; Guglielmo S.; Dei S. (2022). Overcoming Multidrug Resistance (MDR): Design, Biological Evaluation and Molecular Modelling Studies of 2,4-Substituted Quinazoline Derivatives. CHEMMEDCHEM, pp. e202200027-21, ISSN:1860-7179 DOI Accesso ONLINE all'editore

Chiaramonte N.; Angeli A.; Sgambellone S.; Bonardi A.; Nocentini A.; Bartolucci G.; Braconi L.; Dei S.; Lucarini L.; Teodori E.; Gratteri P.; Wunsch B.; Supuran C.T.; Romanelli M.N. (2022). 2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 228, pp. 0-0, ISSN:0223-5234 DOI

Borgonetti V.; Meacci E.; Pierucci F.; Romanelli M.N.; Galeotti N. (2022). Dual HDAC/BRD4 Inhibitors Relieves Neuropathic Pain by Attenuating Inflammatory Response in Microglia After Spared Nerve Injury. NEUROTHERAPEUTICS, pp. 1-15, ISSN:1933-7213 DOI

Braconi, Laura; Teodori, Elisabetta; Riganti, Chiara; Coronnello, Marcella; Nocentini, Alessio; Bartolucci, Gian Luca; Pallecchi, Marco; Contino, Marialessandra; Manetti, Dina; Romanelli, Maria Novella; Supuran, Claudiu T; Dei, Silvia (2022). New dual P-Glycoprotein (P-gp) and human carbonic anhydrase XII (hCA XII) inhibitors as Multidrug Resistance (MDR) reversers in cancer cells. JOURNAL OF MEDICINAL CHEMISTRY, vol. 65, pp. 14655-14672, ISSN:0022-2623 DOI Accesso ONLINE all'editore

Romanelli, Maria Novella; Manetti, Dina; Braconi, Laura; Dei, Silvia; Gabellini, Alessio; Teodori, Elisabetta (2022). The piperazine scaffold for novel drug discovery efforts: the evidence to date. EXPERT OPINION ON DRUG DISCOVERY, pp. 1-16, ISSN:1746-0441 DOI

Chiaramonte N.; Gabellini A.; Angeli A.; Bartolucci G.; Braconi L.; Dei S.; Teodori E.; Supuran C.T.; Romanelli M.N. (2022). New Histamine-Related Five-Membered N-Heterocycle Derivatives as Carbonic Anhydrase I Activators. MOLECULES, vol. 27, pp. 0-0, ISSN:1420-3049 DOI

Teodori, Elisabetta; Braconi, Laura; Manetti, Dina; Romanelli, Maria Novella; Dei, Silvia (2022). The Tetrahydroisoquinoline Scaffold in ABC Transporter Inhibitors that Act as Multidrug Resistance (MDR) Reversers. CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 22, pp. 2535-2569, ISSN:1873-4294 DOI

Maach S.; Chiaramonte N.; Borgonetti V.; Sarno F.; Pierucci F.; Dei S.; Teodori E.; Altucci L.; Meacci E.; Galeotti N.; Romanelli M.N. (2022). Dual HDAC–BRD4 inhibitors endowed with antitumor and antihyperalgesic activity. MEDICINAL CHEMISTRY RESEARCH, pp. 1-15, ISSN:1054-2523 DOI

Lucarini E., Nocentini A., Bonardi A., Chiaramonte N., Parisio C., Micheli L., Toti A., Ferrara V., Carrino D., Pacini A., Romanelli M.N., Supuran C.T., Ghelardini C., Di Cesare Mannelli L. (2021). Carbonic Anhydrase IV Selective Inhibitors Counteract the Development of Colitis-Associated Visceral Pain in Rats. CELLS, vol. 10, pp. 2540-2555, ISSN:2073-4409 DOI

Targowska-Duda K.M.; Budzynska B.; Michalak A.; Wnorowski A.; Loland C.J.; Maj M.; Manetti D.; Romanelli M.N.; Jozwiak K.; Biala G.; Arias H.R. (2021). Type I and type II positive allosteric modulators of α7 nicotinic acetylcholine receptors induce antidepressant-like activity in mice by a mechanism involving receptor potentiation but not neurotransmitter reuptake inhibition. Correlation with mTOR intracellular pathway activation. EUROPEAN NEUROPSYCHOPHARMACOLOGY, vol. 52, pp. 31-47, ISSN:0924-977X DOI

Romanelli, Maria Novella; Borgonetti, Vittoria; Galeotti, Nicoletta (2021). Dual BET/HDAC inhibition to relieve neuropathic pain: recent advances, perspectives, and future opportunities. PHARMACOLOGICAL RESEARCH, pp. 105901-105916, ISSN:1043-6618 DOI

Balducci, Valentina; Credi, Caterina; Sacconi, Leonardo; Romanelli, Maria Novella; Sartiani, Laura; Cerbai, Elisabetta (2021). The HCN channel as a pharmacological target: Why, where, and how to block it. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, pp. 1-9, ISSN:0079-6107 DOI

Parri, Lorenzo; Fort, Ada; Lo Grasso, Anna; Mugnaini, Marco; Vignoli, Valerio; Capasso, Clemente; Del Prete, Sonia; Romanelli, Maria Novella; Supuran, Claudiu T. (2021). Evaluating the efficiency of enzyme accelerated CO2 capture: chemical kinetics modelling for interpreting measurement results. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 36, pp. 394-401, ISSN:1475-6366 DOI

Ruzzolini J, Laurenzana A, Andreucci E, Peppicelli S, Bianchini F, Carta F, Supuran CT, Romanelli MN, Nediani C, Calorini L. (2020). A potentiated cooperation of carbonic anhydrase IX and histone deacetylase inhibitors against cancer. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 391-397, ISSN:1475-6366 DOI

Matucci R.; Bellucci C.; Martino M.V.; Nesi M.; Manetti D.; Welzel J.; Bartz U.; Holze J.; Trankle C.; Mohr K.; Mazzolari A.; Vistoli G.; Dei S.; Teodori E.; Romanelli M.N. (2020). Carbachol dimers with primary carbamate groups as homobivalent modulators of muscarinic receptors. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 883, pp. 1-9, ISSN:0014-2999 DOI

Teodori E.; Braconi L.; Bua S.; Lapucci A.; Bartolucci G.; Manetti D.; Romanelli M.N.; Dei S.; Supuran C.T.; Coronnello M. (2020). Dual P-glycoprotein and CA XII inhibitors: A new strategy to reverse the P-gp Mediated Multidrug Resistance (MDR) in cancer cells y. MOLECULES, vol. 25, pp. 1-26, ISSN:1420-3049 DOI Accesso ONLINE all'editore

Arias H.R.; Ghelardini C.; Lucarini E.; Tae H.-S.; Yousuf A.; Marcovich I.; Manetti D.; Romanelli M.N.; Elgoyhen A.B.; Adams D.J.; Di Cesare Mannelli L. (2020). (E)-3-Furan-2-yl- N- p-tolyl-acrylamide and its Derivative DM489 Decrease Neuropathic Pain in Mice Predominantly by α7 Nicotinic Acetylcholine Receptor Potentiation. ACS CHEMICAL NEUROSCIENCE, vol. 11, pp. 3603-3614-3614, ISSN:1948-7193 DOI

Niccolò Chiaramonte, Soumia Maach, Caterina Biliotti, Andrea Angeli, Gian luca Bartolucci, Laura Braconi, Silvia Dei, Elisabetta Teodori, Claudiu T. Supuran, Maria Novella Romanelli (2020). Synthesis and carbonic anhydrase activating properties of a series of 2-amino-imidazolines structurally related to clonidine. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 1003-1010, ISSN:1475-6366 DOI

Qays Kharouf, Paulo Pinares-Garcia, M. Novella Romanelli, Christopher A. Reid (2020). Testing broad-spectrum and isoform-preferring HCN channel blockers for anticonvulsant properties in mice. EPILEPSY RESEARCH, vol. 168, pp. 0-0, ISSN:0920-1211 DOI Accesso ONLINE all'editore

Braconi L.; Bartolucci G.; Contino M.; Chiaramonte N.; Giampietro R.; Manetti D.; Perrone M.G.; Romanelli M.N.; Colabufo N.A.; Riganti C.; Dei S.; Teodori E. (2020). 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 974-992, ISSN:1475-6366 DOI

Qays Kharouf, A. Marie Phillips, Lauren E. Bleakley, Emma Morrisroe, Julia Oyrer, Linghan Jia, Andreas Ludwig, Liang Jin, Joseph A. Nicolazzo, Elisabetta Cerbai, M. Novella Romanelli, Steven Petrou, Christopher A. Reid (2020). The hyperpolarization-activated cyclic nucleotide-gated 4 channel as a potential anti-seizure drug target. BRITISH JOURNAL OF PHARMACOLOGY, vol. 177, pp. 3712-3729, ISSN:1476-5381 DOI

Silvia Dei, Laura Braconi, Alfonso Trezza, Marta Menicatti, Marialessandra Contino, Marcella Coronnello, Niccolò Chiaramonte, Dina Manetti, Maria Grazia Perrone, Maria Novella Romanelli, Chatchanok Udomtanakunchai, Nicola Antonio Colabufo, Gian luca Bartolucci, Ottavia Spiga, Milena Salerno, Elisabetta Teodori (2019). Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug-resistance (MDR) modulators. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 172, pp. 71-94, ISSN:1768-3254, Elsevier Masson SAS: DOI Accesso ONLINE all'editore

Niccolò Chiaramontea, Silvia Bua, Andrea Angeli, Marta Ferraroni, Ilaria Picchioni, Gianluca Bartolucci, Laura Braconi, Silvia Dei, Elisabetta Teodori, Claudiu T. Supuran, Maria Novella Romanelli (2019). Sulfonamides incorporating piperazine bioisosteres as potent human carbonic anhydrase I, II, IV and IX inhibitors. BIOORGANIC CHEMISTRY, vol. 91, pp. 1-11, ISSN:0045-2068 DOI

Braconi L., Bartolucci G., Manetti D., Romanelli M.N., Dei S., Teodori E. (2019). Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers. In: XXVI National Meeting in Medicinal Chemistry, Milano, 16-19 luglio 2019, Società Chimica Italiana, pp. P79-P79.

Dina Manetti*† , Alexandra Garifulina‡, Gian Luca Bartolucci , Carla Bazzicalupi§ , Cristina Bellucci†, Niccolò Chiaramonte†, Silvia Dei†, Lorenzo Di Cesare Mannelli∥, Carla Ghelardini∥, Paola Gratteri⊥ , Ekaterina Spirova‡, Irina Shelukhina‡, Elisabetta Teodori†, Katia Varani#, Victor Tsetlin‡, Maria Novella Romanelli† (2019). New Rigid Nicotine Analogues, Carrying a Norbornane Moiety, Are Potent Agonists of α7 and α3∗ Nicotinic Receptors. JOURNAL OF MEDICINAL CHEMISTRY, vol. 62, pp. 1887-1901, ISSN:0022-2623 DOI Accesso ONLINE all'editore

Mehrnoush Zobeiri, Rahul Chaudhary, Anne Blaich, Matthias Rottmann, Stefan Herrmann, Patrick Meuth, Pawan Bista, Tatyana Kanyshkova, Annika Lüttjohann, Venu Narayanan, Petra Hundehege, Sven G. Meuth, Maria Novella Romanelli, Francisco J. Urbano, Hans-Christian Pape, Thomas Budde, Andreas Ludwig (2019). The hyperpolarization-activated HCN4 channel is Important for proper maintenance of oscillatory activity in the thalamocortical system. CEREBRAL CORTEX, pp. 1-14, ISSN:1460-2199 DOI

Silvia Dei, Laura Braconi, Maria Novella Romanelli, Elisabetta Teodori (2019). Recent advances in the search of BCRP- and dual P-gp/BCRP-based multidrug resistance modulators. CANCER DRUG RESISTANCE, vol. 2, pp. 710-743, ISSN:2578-532X DOI

Maria Novella Romanelli, Martina Del Lungo, Luca Guandalini,Mehrnoush Zobeiri, Andras Gyokeres, TAmas Arpadffy-Lovas, Istvan Koncz, Laura Sartiani, Gian Luca Bartolucci, Silvia Dei, Dina Manetti, Elisabetta Teodori, Thomas Budde, Elisabetta Cerbai (2019). EC18 as a Tool To Understand the Role of HCN4 Channels in Mediating Hyperpolarization-Activated Current in Tissues. ACS MEDICINAL CHEMISTRY LETTERS, vol. 10, pp. 584-589, ISSN:1948-5875 DOI

Masi, Alessio; Romanelli, Maria Novella; Mannaioni, Guido; Cerbai, Elisabetta (2019). Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels. In: Masi A, Romanelli MN, Mannaioni G, Cerbai E. The Oxford Handbook of Neuronal Ion Channels, pp. 1-2 Oxford University Press, ISBN:9780190669164. DOI

Teodori E.; Contino M.; Riganti C.; Bartolucci G.; Braconi L.; Manetti D.; Romanelli M.N.; Trezza A.; Athanasios A.; Spiga O.; Perrone M.G.; Giampietro R.; Gazzano E.; Salerno M.; Colabufo N.A.; Dei S. (2019). Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 182, pp. 1-25, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Resta, F.*; Micheli, L.; Laurino, A.; Spinelli, V.; Mello, T.; Sartiani, L.; Di Cesare Mannelli, L.; Cerbai, E.; Ghelardini, C.; Romanelli, M.N.; Mannaioni, G.; Masi, A. (2018). Selective HCN1 block as a strategy to control oxaliplatin-induced neuropathy. NEUROPHARMACOLOGY, vol. 131, pp. 403-413, ISSN:0028-3908 DOI Accesso ONLINE all'editore

Dini, Leonardo; Del Lungo, Martina; Resta, Francesco; Melchiorre, Michele; Spinelli, Valentina; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Laurino, Annunziatina; Sartiani, Laura; Coppini, Raffaele; Mannaioni, Guido; Cerbai, Elisabetta; Romanelli, Maria Novella (2018). Selective Blockade of HCN1/HCN2 Channels as a Potential Pharmacological Strategy Against Pain. FRONTIERS IN PHARMACOLOGY, vol. 9, pp. 1252-1252, ISSN:1663-9812 DOI

E. Teodori, M. Coronnello, S. Bua, L. Braconi, D. Manetti, M.N. Romanelli, C. Supuran, S. Dei (2018). P-glycoprotein and carbonic anhydrases hybrid inhibitors: a new strategy to reverse multidrug resistance (MDR) in cancer cells. In: Italian-Spanish-Portoguese Joint Meeting in Medicinal Chemistry MedChemSicily 2018, Palermo, 17-20 luglio, Società Chimica Italiana, pp. P 31-P 31.

Chiaramonte, Niccolò*; Romanelli, Maria Novella; Teodori, Elisabetta; Supuran, Claudiu T. (2018). Amino acids as building blocks for carbonic anhydrase inhibitors. METABOLITES, vol. 8, pp. 1-22, ISSN:2218-1989 DOI Accesso ONLINE all'editore

Silvia, Dei; Maria Novella Romanelli, ; Dina, Manetti; Niccolò, Chiaramonte; Marcella, Coronnello; Milena, Salerno; Elisabetta, Teodori (2018). Design and synthesis of aminoester heterodimers containing flavone or chromone moieties as modulators of P-glycoprotein-based multidrug resistance (MDR). BIOORGANIC & MEDICINAL CHEMISTRY, vol. 26, pp. 50-64, ISSN:0968-0896 DOI Accesso ONLINE all'editore

Angeli, Andrea; Chiaramonte, Niccolò; Manetti, Dina; Romanelli, Maria Novella; Supuran, Claudiu T (2018). Investigation of piperazines as human carbonic anhydrase I, II, IV and VII activators. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 33, pp. 303-308, ISSN:1475-6366 DOI

Silvia, Dei; Marcella, Coronnello; Gian Luca Bartolucci, ; Dina, Manetti; Maria Novella Romanelli, ; Chatchanok, Udomtanakunchai; Milena, Salerno; Elisabetta, Teodori (2018). Design and synthesis of new potent N,N-bis(arylalkyl)piperazine derivatives as multidrug resistance (MDR) reversing agents. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 147, pp. 7-20, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Niccolò Chiaramonte, Silvia Bua, Marta Ferraroni, Alessio Nocentini, Alessandro Bonardi, Gian Luca Bartolucci, Maria Concetta Durante, Laura Lucarini, Donata Chiapponi, Silvia Dei, Dina Manetti, Elisabetta Teodori, Paola Gratteri, Emanuela Masini, Claudiu T. Supuran, Maria Novella Romanelli (2018). 2-Benzylpiperazine: a new scaffold for potent human Carbonic Anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 151, pp. 363-375, ISSN:1768-3254 DOI

Spinelli, Valentina; Sartiani, Laura; Mugelli, Alessandro; Romanelli, Maria Novella; Cerbai, Elisabetta (2018). Hyperpolarization-activated cyclic-nucleotide-gated channels: pathophysiological, developmental, and pharmacological insights into their function in cellular excitability. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, pp. 1-8, ISSN:0008-4212 DOI

Dina Manetti, Cristina Bellucci, Niccolo` Chiaramonte, Silvia Dei, Elisabetta Teodori, Maria Novella Romanelli (2018). Designing selective modulators for the nicotinic receptor subtypes: challenges and opportunities. FUTURE MEDICINAL CHEMISTRY, pp. 433-459, ISSN:1756-8919 DOI Accesso ONLINE all'editore

Teodori, Elisabetta; Dei, Silvia; Coronnello, Marcella; Floriddia, Elisa; Bartolucci, Gianluca; Manetti, Dina; Romanelli, Maria Novella; Santo Domingo Porqueras, Diego; Salerno, Milena (2017). N-alkanol-N-cyclohexanol amine aryl esters: Multidrug resistance (MDR) reversing agents with high potency and efficacy. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 127, pp. 586-598, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Sanna, Maria Domenica; Guandalini, Luca; Romanelli, Maria Novella; Galeotti, Nicoletta (2017). The new HDAC1 inhibitor LG325 ameliorates neuropathic pain in a mouse model. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, vol. 160, pp. 70-75, ISSN:0091-3057 DOI Accesso ONLINE all'editore

Martino, Maria Vittoria; Guandalini, Luca; Di Cesare Mannelli, Lorenzo; Menicatti, Marta; Bartolucci, Gianluca; Dei, Silvia; Manetti, Dina; Teodori, Elisabetta; Ghelardini, Carla; Romanelli, Maria Novella (2017). Piperazines as nootropic agents: New derivatives of the potent cognition-enhancer DM235 carrying hydrophilic substituents. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 25, pp. 1795-1803, ISSN:0968-0896 DOI Accesso ONLINE all'editore

Wadenberg, Marie-Louise G; Manetti, Dina; Romanelli, Maria Novella; Arias, Hugo R. (2017). Significance of the nicotinic alpha7 receptor in cognition and antipsychotic-like behavior in the rat. BEHAVIOURAL BRAIN RESEARCH, vol. 333, pp. 129-134, ISSN:0166-4328 DOI Accesso ONLINE all'editore

Teodori, Elisabetta; Dei, Silvia; Bartolucci, Gianluca; Perrone, Maria Grazia; Manetti, Dina; Romanelli, Maria Novella; Contino, Marialessandra; Colabufo, Nicola Antonio (2017). Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers. CHEMMEDCHEM, vol. 12, pp. 1369-1379, ISSN:1860-7179 DOI Accesso ONLINE all'editore

Sartiani, Laura; Mannaioni, Guido; Masi, Alessio; Romanelli, Maria Novella; Cerbai, Elisabetta (2017). The Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels: from Biophysics to Pharmacology of a Unique Family of Ion Channels. PHARMACOLOGICAL REVIEWS, vol. 69, pp. 354-395, ISSN:0031-6997 DOI

Leist, Michael; Datunashvilli, Maia; Kanyshkova, Tatyana; Zobeiri, Mehrnoush; Aissaoui, Ania; Cerina, Manuela; Romanelli, Maria Novella; Pape, Hans-Christian; Budde, Thomas (2016). Two types of interneurons in the mouse lateral geniculate nucleus are characterized by different h-current density. SCIENTIFIC REPORTS, vol. 6, pp. 0-0, ISSN:2045-2322 DOI Accesso ONLINE all'editore

Manetti, Dina; Bellucci, Cristina; Dei, Silvia; Teodori, Elisabetta; Varani, Katia; Spirova, Ekaterina; Kudryavtsev, Denis; Shelukhina, Irina; Tsetlin, Victor; Romanelli, Maria Novella (2016). New quinoline derivatives as nicotinic receptor modulators. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 110, pp. 246-258, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Teodori, E.; Dei, S.; Floriddia, E.; Perrone, M. G.; Manetti, D.; Romanelli, M. N.; Contino, M.; Colabufo, N. A. (2016). SAR studies on 6,7-dimethoxytetrahydroisoquinoline derivatives as MDR reverters: requirements for potency and selectivity. In: XXIV National Meeting in Medicinal Chemistry, Perugia, 11-14 Settembre 2016, Società Chimica Italiana, pp. PC-156-PC-156.

Matucci, Rosanna; Nesi, Marta; Martino, Maria Vittoria; Bellucci, Cristina; Manetti, Dina; Ciuti, Elisa; Mazzolari, Angelica; Dei, Silvia; Guandalini, Luca; Teodori, Elisabetta; Vistoli, Giulio; Romanelli, Maria Novella (2016). Carbachol dimers as homobivalent modulators of muscarinic receptors. BIOCHEMICAL PHARMACOLOGY, vol. 108, pp. 90-101, ISSN:0006-2952 DOI

Romanelli, M.N.; Bellucci, C.; Dei, S.; Ghelardini, C.; Manetti, D.; Teodori, E.; Gualtieri, F. (2016). The double life of UNIFI nootropics. In: XXIV National Meeting in Medicinal Chemistry, Perugia, 11-14 Settembre 2016, Società Chimica Italiana, pp. OC-8-OC-8.

Romanelli, Maria Novella; Sartiani, Laura; Masi, Alessio; Mannaioni, Guido; Manetti, Dina; Mugelli, Alessandro; Cerbai, Elisabetta (2016). HCN Channels Modulators: The Need for Selectivity. CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 16, pp. 1764-1791, ISSN:1873-4294 Accesso ONLINE all'editore

Teodori, Elisabetta; Dei, Silvia; Floriddia, Elisa; Coronnello, Marcella; Bartolucci, Gianluca; Manetti, Dina; Maria Novella Romanelli, Salerno, Milena (2015). Aminoarylesters as multidrug resistance (MDR) reverting agents endowed with high potency and efficacy. In: IXth Joint Meeting in Medicinal Chemistry, Atene, 7-10 giugno 2015, Hellenic Society of Medicinal Chemistry, pp. O11-O11.

Sartiani, Laura; Romanelli, Maria Novella; Mugelli, Alessandro; Cerbai, Elisabetta (2015). Updates on HCN channels in the heart: Function, Dysfunction and pharmacology. CURRENT DRUG TARGETS, vol. 16, pp. 868-876, ISSN:1389-4501 DOI Accesso ONLINE all'editore

E. Teodori; S. Dei; E. Floriddia; M. G. Perrone; D. Manetti; M. N. Romanelli; M. Contino; N. A. Colabufo (2015). Arylamino Esters as P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity. CHEMMEDCHEM, vol. 10, pp. 1339-1343, ISSN:1860-7179 DOI Accesso ONLINE all'editore

Martino, M. V.; DI CESARE MANNELLI, L. ; Bartolucci, G.; S, . DEI; Manetti, D.; Ghelardini, C.; Teodori, E.; Romanelli, M. N. (2015). 2- or 3-Substituted piperazines as nootropic agents: carbethoxy and hydroxymethyl analogues of the cognition-enhancer DM235. In: XXIII National Meeting on Medicinal Chemistry and 9th Young Medicinal Chemists Symposium (XXIII NMMC – 9th NPCF), Salerno, 6-9 settembre 2015, Edizioni Ziino, pp. 136-136.

S, . DEI; Teodori, E.; Floriddia, E.; Bellucci, C.; Manetti, D.; Romanelli, M. N.; Salerno, M. (2015). Flavonoid aminoesters acting as reversing agents of Pgp-dependent multidrug resistance (MDR). In: IXth Joint Meeting in Medicinal Chemistry, Atene, 7-10 giugno 2015, Hellenic Society of Medicinal Chemistry, pp. P88-P88.

Guandalini, Luca; Martino, Maria Vittoria; Di Cesare Mannelli, Lorenzo; Bartolucci, Gianluca; Melani, Fabrizio; Malik, Ruchi; Dei, Silvia; Floriddia, Elisa; Manetti, Dina; Orlandi, Francesca; Teodori, Elisabetta; Ghelardini, Carla; Romanelli, Maria Novella (2015). Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the cognition-enhancer DM235. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 25, pp. 1700-1704, ISSN:0960-894X DOI

Silvia Dei; Marcella Coronnello; Elisa Floriddia; Gianluca Bartolucci; Cristina Bellucci; Luca Guandalini; Dina Manetti; Maria Novella Romanelli; Milena Salerno; Ivan Bello; Enrico Mini; Elisabetta Teodori (2014). Multidrug resistance (MDR) reversers: High activity and efficacy in a series of asymmetrical N,N-bis(alkanol)amine aryl esters. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 87, pp. 398-412, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Balliu, Manjola; Guandalini, Luca; Romanelli, Maria Novella; D'Amico, Massimo; Paoletti, Francesco (2014). HDAC-inhibitor (S)-8 disrupts HDAC6-PP1 complex prompting A375 melanoma cell growth arrest and apoptosis.. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. 19, pp. 143-154, ISSN:1582-1838 DOI Accesso ONLINE all'editore

Elisa Floriddia; Cristina Bellucci; Dina Manetti; Maria Novella Romanelli; Milena Salerno; Elisabetta Teodori; Silvia Dei (2014). New potent piperazine and aminopiperidine derivatives as reverting agents of Multidrug Resistance (MDR). In: VIII Meeting Nuove Prospettive in Chimica Farmaceutica, Parma, 9-11 Giugno 2014, Società Chimica Italiana Divisione di Chimica Farmaceutica, pp. O7-O7.

Laurenzana, A.; Balliu, M.; Cellai, C.; Romanelli, M.N.; Paoletti, F. (2013). Effectiveness of the histone deacetylase inhibitor (S)-2 against LNCaP and PC3 human prostate cancer cells. PLOS ONE, vol. 8, pp. 1-11, ISSN:1932-6203 DOI

L. Guandalini; M. Balliu; C. Cellai; M.V. Martino; A. Nebbioso; C. Mercurio; V. Carafa; G. Bartolucci; S. Dei; D. Manetti; E. Teodori; S. Scapecchi; L. Altucci; F. Paoletti; M.N. Romanelli (2013). Design, synthesis and preliminary evaluation of a series of histone deacetylase inhibitors carrying a benzodiazepine ring. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 66, pp. 56-68, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Silvia Dei; Elisa Floriddia; Marcella Coronnello; Cristina Bellucci; Dina Manetti; Francesca Orlandi; Maria Novella Romanelli; Milena Salerno; Serena Scapecchi; Elisabetta Teodori (2013). New multidrug resistance (MDR) agents endowed with good potency and efficacy. In: XXII National Meeting on Medicinal Chemistry, Roma, 10-13 Settembre 2013, Società Chimica Italiana Divisione di Chimica Farmaceutica, pp. P39-P39.

Maria Vittoria Martino; Serena Scapecchi; Cristina Bellucci; Marta Nesi; Elisa Ciuti; Silvia Dei; Luca Guandalini; Dina Manetti; Elisabetta Teodori; Rosanna Matucci; Giulio Vistoli; Maria Novella Romanelli (2013). Design, Synthesis and binding affinity of carbachol dimers as bitopic ligands. In: 31 th Camerino-Cyprus-Noordwijkerhout Symposium, Camerino, 19-23 Maggio 2013, Università degli studi di Camerino, pp. 91-91.

Elisa Floriddia; Francesca Orlandi; Cristina Bellucci; Dina Manetti; Maria Novella Romanelli; Milena Salerno; Serena Scapecchi; Elisabetta Teodori; Silvia Dei (2013). New N-alkanol-N-cyclohexanolamine aryl ester derivatives as reverting agents of Multidrug Resistance (MDR). In: VIII Meeting Nuove Prospettive in Chimica Farmaceutica, Savigliano (CN), 29-31 Maggio 2013, Società Chimica Italiana Divisione di Chimica Farmaceutica, pp. P1.8-P1.8.

F. Orlandi; M. Coronnello; C. Bellucci; S. Dei; L. Guandalini; D. Manetti; C. Martelli; M. N. Romanelli; S. Scapecchi; M. Salerno; H. Menif; I. Bello; E. Mini; E. Teodori (2013). New structure–activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR). BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, pp. 456-465, ISSN:0968-0896 DOI Accesso ONLINE all'editore

Dina Manetti; Cristina Bellucci; Silvia Dei; Luca Guandalini; Serena Scapecchi; Elisabetta Teodori; Katia Varani; Maria Novella Romanelli (2013). Design, Synthesis and binding affinity of new ligands for the central nicotinic receptors. In: XXII National Meeting on Medicinal Chemistry, Roma, 10-13 Settembre 2013, Società Chimica Italiana Divisione di Chimica Farmaceutica, pp. S43-S43.

Luca Guandalini; Maria Vittoria Martino; Lorenzo Di Cesare Mannelli; Cristina Bellucci; Silvia Dei; Dina Manetti; Serena Scapecchi; Elisabetta Teodori; Carla Ghelardini; Maria Novella Romanelli (2012). New analogues of the potent nootropic drug DM235: 2-or 3-phenylpiperazines with limited conformational flexibility. In: 21 th National Meeting on Medicinal Chemistry, Palermo, 17-20 Luglio 2012, Società Chimica Italiana Divisione di Chimica Farmaceutica, pp. 74-74.

L. Guandalini; E. Martini; L. Di Cesare Mannelli; S. Dei; D. Manetti; S. Scapecchi; E. Teodori; C. Ghelardini; M.N. Romanelli (2012). Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22, pp. 1936-1939, ISSN:0960-894X DOI Accesso ONLINE all'editore

M. Del Lungo; M. Melchiorre; L. Guandalini; L. Sartiani; A. Mugelli; I. Koncz; T. Szel; A. Varro; M. N. Romanelli; E. Cerbai (2012). Novel blockers of hyperpolarization-activated current with isoform selectivity in recombinant cells and native tissue.. BRITISH JOURNAL OF PHARMACOLOGY, vol. 166, pp. 602-616, ISSN:0007-1188 DOI Accesso ONLINE all'editore

Francesca Orlandi; Marcella Coronnello; Cristina Bellucci; Dina Manetti; Maria Novella Romanelli; Milena Salerno; Serena Scapecchi; Elisabetta Teodori; Silvia Dei (2012). Unexpected Multidrug Resistance (MDR) reverting activity of a new series of N,N-bis(arylalkanol)amine aryl esters. In: 21th National Meeting of Medicinal Chemistry, Palermo, 17-20 Luglio 2012, Società Chimica Italiana Divisione di Chimica Farmaceutica, pp. 92-92.

C. Cellai; M. Balliu; A. Laurenzana; L. Guandalini; R. Matucci; D. Miniati; E. Torre; A. Nebbioso; V. Carafa; L. Altucci; M. N. Romanelli; F. Paoletti (2012). The new low-toxic histone deacetylase inhibitor S-(2) induces apoptosis in various acute myeloid leukemia cells. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. 16, pp. 1758-1765, ISSN:1582-1838 DOI

E. Teodori; M. Coronnello; S.Dei; D. Manetti; F. Orlandi; M. N. Romanelli; S. Scapecchi; M. Salerno (2011). Multidrug Resistance (MDR) reverting agents:structure-activity relationships of a series of N,Nbis(arylalkanol)amine aryl esters. In: XXIV Congresso Nazionale, Lecce, Italy, 11-16 settembre 2011, Società Chimica Italiana, pp. 459-459.

E. Martini; L. Di Cesare Mannelli; G. Bartolucci; C. Bertucci; S. Dei; C. Ghelardini; L. Guandalini; D. Manetti; S. Scapecchi; E. Teodori; M. N. Romanelli (2011). Synthesis and Biological Evaluation of 3,7-Diazabicyclo[4.3.0]2 nonan-8-ones as Potential Nootropic and Analgesic Drugs. JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, pp. 2512-2516, ISSN:0022-2623 DOI Accesso ONLINE all'editore

I. Koncz; T. Szél; K. Jaeger; I. Baczkó; E. Cerbai; M.N. Romanelli; J.G. Papp; A. Varró (2011). Selective Pharmacological Inhibition of the Pacemaker Channel Isoforms (HCN1-4) as New Possible Therapeutical Targets. CURRENT MEDICINAL CHEMISTRY, vol. 18, pp. 3662-3674, ISSN:0929-8673 DOI Accesso ONLINE all'editore

Martelli, Cecilia; Dei, Silvia; Lambert, C.; Manetti, Dina; Orlandi, Francesca; Romanelli, MARIA NOVELLA; Scapecchi, Serena; Salerno, M.; Teodori, Elisabetta (2011). Inhibition of P-glycoprotein-mediated Multidrug Resistance (MDR) by N,N-bis(cyclohexanol)amine aryl esters: further restriction of molecular flexibility maintains high potency and efficacy. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, pp. 106-109, ISSN:0960-894X DOI Accesso ONLINE all'editore

L. Guandalini; E. Martini; L. Di Cesare Mannelli; S. Dei; D. Manetti; S. Scapecchi; E. Teodori; C. Ghelardini; M. Novella Romanelli (2011). Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs. In: XXIV Congresso Nazionale della Società Chimica Italiana, Lecce, 11-16 Settembre 2011, società chimica italiana, pp. 442-442.

Martelli, Cecilia; Coronnello, MARCELLA MARIA; Dei, Silvia; Manetti, Dina; Orlandi, Francesca; Scapecchi, Serena; Romanelli, MARIA NOVELLA; Salerno, M.; Mini, Enrico; Teodori, Elisabetta (2010). Structure-activity relationships studies in a series of N,N-bis(alkanol)amine aryl esters as P-glycoprotein (Pgp) dependent multidrug resistance (MDR) inhibitors. JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, pp. 1755-1762, ISSN:0022-2623 DOI Accesso ONLINE all'editore

M. Melchiorre; M. Del Lungo; L. Guandalini; E. Martini; S. Dei; D. Manetti; S. Scapecchi; E. Teodori; L. Sartiani; A. Mugelli; E. Cerbai; M. N. Romanelli (2010). Design, synthesis and preliminary biological evaluation of new isoform-selective f-current blockers.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, pp. 6773-6777, ISSN:0022-2623 DOI Accesso ONLINE all'editore

M.Novella Romanelli; Michele Melchiorre; Luca Guandalini; Martina Del Lungo; Silvia Dei; Dina Manetti; Serena Scapecchi; Elisabetta Teodori; Elisabetta Cerbai; Laura Sartiani; Alessandro Mugelli; Andras Varro (2010). New phenylalkylamines as isoform selective HCN-Channels blockers. In: 21st International Symposium on Medicinal Chemistry, Brussels, Belgium, September 5-9, Thomson Reuters, pp. 171-171.

M.N. Romanelli; A. Mugelli; E. Cerbai; L. Sartiani; M. Del Lungo; M. Melchiorre (2010). New isoform-selective HCN blockers. Numero: WO2011/000915 A1 Università di Firenze

S. Scapecchi; M. Nesi; R. Matucci; C. Bellucci; M. Buccioni; S. Dei; L. Guandalini; D. Manetti; C. Martelli; E. Martini; G. Marucci; F. Orlandi; M. N. Romanelli; E. Teodori; R. Cirilli (2010). Synthesis, Affinity Profile and Functional Activity of Potent Chiral Muscarinic Antagonists with a Pyrrolidinylfuran Structure. JOURNAL OF MEDICINAL CHEMISTRY, vol. 53 (1), pp. 201-207, ISSN:1520-4804 DOI Accesso ONLINE all'editore

Teodori E.; Martelli C.; Dei S.; Frosini M.; Manetti D.; Neri A.; Orlandi F.; Romanelli M.N.; Scapecchi S.; Salerno M.; Sgaragli G. (2010). Inhibition of P-glycoprotein-mediated multidrug resistance (MDR) by N,N-bis(cyclohexanol)amine aryl esters: structure-activity relationships. In: XX National Meeting on Medicinal Chemistry, Abano Terme (PD), September 12-16, 2010, Italian Chemical Society Division of Medicinal Chemistry, pp. 159-159.

Martini, Elisabetta; Salvicchi, A.; Ghelardini, Carla; Manetti, Dina; Dei, Silvia; Guandalini, Luca; Martelli, Cecilia; Melchiorre, Michele; Cellai, Cristina; Scapecchi, Serena; Teodori, Elisabetta; Romanelli, MARIA NOVELLA (2009). Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 17, pp. 7606-7614, ISSN:1464-3391 DOI

Luca Guandalini; Martina Del Lungo; Silvia Dei; Dina Manetti; Serena Scapecchi; Elisabetta Teodori; Elisabetta Cerbai; Laura Sartiani; M. Novella Romanelli (2009). Design, synthesis and electrophysiological studies of new blockers of HCN channels. In: XXIII Congresso Nazionale della Società Chimica Italiana, Sorrento, 5-10 Luglio 2009, Società Chimica Italiana, pp. 154-154.

M.N. Romanelli; A. Mugelli; E. Cerbai; L. Sartiani; M. Del Lungo; M. Melchiorre (2009). Nuovi bloccanti isoforma-selettivi dei canali HCN.. Numero: 9739PTIT Università defli studi di Firenze

M. Del Lungo; M. Melchiorre; L. Sartiani; M. Biel; A. Varro; M.N. Romanelli; A. Mugelli; E. Cerbai (2009). Electrophysiological evaluation of novel blockers of If current.. EUROPEAN HEART JOURNAL, vol. 30, pp. 32-32, ISSN:0195-668X

L. Sartiani; M. Del Lungo; M. Melchiorre; M. Biel; A. Varro; M.N. Romanelli; E. Cerbai (2009). Electrophysiological evaluation of novel f-channels blockers.. BIOPHYSICAL JOURNAL, vol. Abstract issue, pp. 664A-664A, ISSN:0006-3495

Elisabetta Teodori; Cecilia Martelli; Milena Salerno; Silvia Dei; Fulvio Gualtieri; Dina Manetti; Francesca Orlandi; Serena Scapecchi; Maria Novella Romanelli (2009). SAR studies in a series of N,N-bis(arylaLKANOL)AMINE ARYL ESTERS AS p-GLYCOPROTEIN (Pgp) dependent multidrug resistance (MDR) inhibitors. In: XXIII Congresso Nazionale della Società Chimica Italiana, Sorrento, 5-10 Luglio 2009, Società Chimica Italiana, pp. 183-183.

Elisabetta Martini; Carla Ghelardini; Monica Norcini; Dina Manetti; Silvia Dei; Serena Scapecchi; Elisabetta Teodori; Maria Novella Romanelli (2009). Design, synthesis and pharmacological evaluation of novel analogues of the two nootropics unifiram (DM232) and sunifiram (DM235). In: III Meeting Nuova prospettive in chimica farmaceutica, Il Ciocco, Castelvecchio Pascoli (LU), 13-14 febbraio 2009, Società Chimica Italiana Divisione di Chimica Farmaceutica, pp. C2.P15-C2.P15.

Luca Guandalini; Cristina Cellai; Anna Laurenzana; Elisabetta Teodori; Silvia Dei; Dina Manetti; Francesco Paoletti; Maria Novella Romanelli; Serena Scapecchi (2009). Design, synthesis and preliminary biological evaluation of new 1,4-benzodiazepine-based compounds as histone deacetylase inhibitors and antileukemic agents. In: III Meeting Nuove prospettive in chimica farmaceutica, Il Ciocco, Castelvecchio Pascoli (LU), 13-14 febbraio 2009, Società Chimica Italiana Divisione di Chimica Farmaceutica, pp. B1.P22-B1.P22.

Martelli, Cecilia; Alderighi, Daniela; Coronnello, MARCELLA MARIA; Dei, Silvia; Frosini, Maria; Bozec, Benedicte Le; Manetti, Dina; Neri, Annalisa; Romanelli, MARIA NOVELLA; Salerno, Milena; Scapecchi, Serena; Mini, Enrico; Sgaragli, Giampietro; Teodori, Elisabetta (2009). N,N-bis(cyclohexanol)amine aryl esters: a new class of highly potent Pgp-dependent multidrug resistance (MDR) inhibitors. JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, pp. 807-817, ISSN:0022-2623 DOI

L. Guandalini; C. Cellai; A. Laurenzana; S. Scapecchi; F. Paoletti; M. N. Romanelli (2008). Design, synthesis and preliminary biological evaluation of new hydroxamate histone deacetylase inhibitors as potential antileukemic agents. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, pp. 5071-5074, ISSN:0960-894X DOI

L. Guandalini; C. Cellai; A. Laurenzana; E. Teodori; S. Dei; D. Manetti; M. Balliù; S. Sdelci; F. Paoletti; M. N. Romanelli; S. Scapecchi. (2008). Design, synthesis and preliminary biological evaluation of new hydroxamate histone deacetylase inhibitors as potential antileukemic agents.. In: XIX National Meeting on Medicinal Chemistry, Verona, 14-18/09/08, Italian Chemical Society Division of Medicinal Chemistry, pp. 26-26.

Vistoli, G.; Pedretti, A.; Dei, Silvia; Scapecchi, Serena; Marconi, C.; Romanelli, MARIA NOVELLA (2008). Docking analyses on human muscarinic receptors: unveiling the subtypes peculiarities in agonists binding. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, pp. 3049-3058, ISSN:0968-0896 DOI

S. Scapecchi; M. Nesi; R. Matucci; C. Bellucci; M. Buccioni; S. Dei; L. Guandalini; D. Manetti; E. Martini; G. Marucci; M.N. Romanelli; E. Teodori; R. Cirilli. (2008). Synthesis and pharmacological characterization of chiral pyrrolidinylfuran derivatives: the discovery of new functionally selective muscarinic agonists. JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, pp. 3905-3912, ISSN:0022-2623 DOI

Martini, Elisabetta; Norcini, Monica; Ghelardini, Carla; Manetti, Dina; Dei, Silvia; Guandalini, Luca; Melchiorre, Michele; Pagella, Simona; Scapecchi, Serena; Teodori, Elisabetta; Romanelli, MARIA NOVELLA (2008). Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, pp. 10034-10042, ISSN:1464-3391 DOI

Martini, Elisabetta; Ghelardini, Carla; Dei, Silvia; Guandalini, Luca; Manetti, Dina; Melchiorre, Michele; Norcini, Monica; Scapecchi, Serena; Teodori, Elisabetta; Romanelli, MARIA NOVELLA (2008). Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, pp. 1431-1443, ISSN:1464-3391 DOI

E. Martini; C. Ghelardini; M. Norcini; D. Manetti; S. Dei; L. Guandalini; M. Melchiorre; S. Scapecchi; E. Teodori; F. Gualtieri; M.N. Romanelli (2008). Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators. In: XIX National Meeting on Medicinal Chemistry, Verona, 14-18/09/08, Italian Chemical Society Division of Medicinal Chemistry, pp. 129-129.

F. Paoletti; MN. Romanelli; C. Cellai; A. Laurenzana; L. Guandalini (2008). Novel hydroxamate histone deacetylase inhibitors. Numero: PCT/IB2008/055424 Università degli Studi di Firenze;A.I.L. Firenze, sezione autonoma di Firenze dell'Associazione Italiana contro le Leucemie, Linfomi e Mieloma -ONLUS

Dei, Silvia; Bellucci, Cristina; Buccioni, M.; Ferraroni, Marta; Guandalini, Luca; Manetti, Dina; Marucci, G.; Matucci, Rosanna; Nesi, Marta; Romanelli, MARIA NOVELLA; Scapecchi, Serena; Teodori, Elisabetta (2008). Muscarinic antagonists with multiple stereocenters: synthesis, affinity profile and functional activity of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine sulfoxide derivatives. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, pp. 5490-5500, ISSN:0968-0896 DOI

F. Paoletti; C. Cellai; M.N. Romanelli; A. Laurenzana; L.Guandalini (2007). Brevetto # FI2007A000288 riguardante lo sviluppo di Nuovi inibitori delle Deacetilasi Instoniche. Data di deposito: 21 Dicembre, 2007. Numero: Brevetto # FI2007A000288 Titolari: Università degli Studi di Firenze e A.I.L. (Associazione Italiana contro le leucemie, linfomi, mieloma) sede di FirenzeInventori:

L. GUANDALINI; M. NORCINI; K. VARANI; M. PISTOLOZZI; C. GOTTI; C. BAZZICALUPI; E. MARTINI; S. DEI; D. MANETTI; S. SCAPECCHI; E. TEODORI; C. BERTUCCI; C. GHELARDINI; M. N. ROMANELLI (2007). Design, Synthesis, and Preliminary Pharmacological Evaluation of New Quinoline Derivatives as Nicotinic Ligands. JOURNAL OF MEDICINAL CHEMISTRY, vol. 50, pp. 4993-5002, ISSN:0022-2623, American Chemical Society:1155 Sixteenth Street Northwest:Washington, DC 20036:(800)227-5558, EMAIL: service@acs.org, INTERNET: http://www.pubs.acs.org, Fax: (614)447-3671: DOI

L. Guandalini; M. Norcini; K. Varani; M. Pistolozzi; E. Martini; S. Dei; F. Gualtieri; D. Manetti; S. Scapecchi; E. Teodori; C. Ghelardini; M.N. Romanelli (2007). Synthesis and pharmacological evaluation of new nicotinic ligands carrying a quinoline nucleus. In: 16th Camerino-Noordwijkerhout symposium, Camerino, 9-13 Settembre 2007, Università degli Studi di Camerino, pp. 99-99.

M. ROMANELLI; F. GUALTIERI (2007). The quest for the treatment of cognitive impairment: alpha 7 nicotinic and alpha 5 GABA-A receptor modulators. EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 17, pp. 1365-1377, ISSN:1354-3776, Ashley Publications Limited:Unitec House, Third Floor, 2 Albert Place, Finchley Central, London N3 1QB United Kingdom:011 44 208 3433883, EMAIL: jdrake@ashley-pub.com, INTERNET: http://www.ashley-pub.com, Fax: 011 44 208 3432313: DOI

L. Raimondi; C. Ghelardini; F. Gualtieri; L. Guandalini; D. Manetti; E. Martini; M.N. Romanelli (2007). DM232 and DM235, two potent cognition-enhancers, increase NO levels in rat adipocytes. In: Frontiers in CNS and Oncology Medicinal Chemistry, Siena, 7-9 Ottobre 2007, Italian Chemical Society Division of Medicinal Chemistry, European Federation for Medicinal Chemistry, pp. 47-47.

Elisabetta Teodori; Cecilia Martelli; Milena Salerno; Nacira Darghal; Silvia Dei; Fulvio Gualtieri; Dina Manetti; Serena Scapecchi; Maria Novella Romanelli (2007). Isomeric N,N-dicyclohexane-4-ol-amine aryl esters: the discovery of a new class of highly potent and efficacious Pgp-dependent MDR inhibitors. In: Fifth Austrian-german-hungarian-italian-polish-slovenian joint meeting on medicinal chemistry (Portoroz, 17-21 June 2007), Portoroz, Slovenia, 17-21 June 2007, Medimond, pp. 85-85.

E. Martini; C. Ghelardini; D. Manetti; S. Dei; L. Guandalini; F. Gualtieri; S. Scapecchi; E. Teodori; M.N.Romanelli (2007). Progettazione, sintesi e valutazione farmacologica preliminare di analoghi strutturali di Sunifiram e Sapunifiram, due potemti agenti nootropi. In: XVIII Convegno Nazionale della Divisione di Chimica Farmaceutica della Società Chimica Italiana, Chieti, 16-20 Settembre 2007, Società Chimica Italiana Divisione di Chimica Farmaceutica, pp. 146-146.

Teodori, Elisabetta; Martelli, Cecilia; Salerno, M.; Darghal, N.; Dei, Silvia; GARNIER SUILLEROT, A.; Gualtieri, Fulvio; Manetti, Dina; Scapecchi, Serena; Romanelli, MARIA NOVELLA (2007). ISOMERIC N,N-BIS(CYCLOHEXANOL)AMINE ARYL ESTERS: THE DISCOVERY OF A NEW CLASS OF HIGHLY POTENT P-GLYCOPROTEIN (PGP)-DEPENDENT MULTIDRUG RESISTANCE (MDR) INHIBITORS. JOURNAL OF MEDICINAL CHEMISTRY, vol. 50, pp. 599-602, ISSN:0022-2623 DOI

M. Romanelli; P. Gratteri; L. Guandalini; E. Martini; C. Bonaccini; F. Gualtieri (2007). Central Nicotinic receptors: structure, function, ligands, and therapeutic potential. CHEMMEDCHEM, vol. 2, pp. 746-767, ISSN:1860-7179 DOI Accesso ONLINE all'editore

Dei, Silvia; Bellucci, Cristina; Buccioni, M.; Ferraroni, Marta; Guandalini, Luca; Manetti, Dina; Martini, Elisabetta; Marucci, G.; Matucci, Rosanna; Nesi, Marta; Romanelli, MARIA NOVELLA; Scapecchi, Serena; Teodori, Elisabetta (2007). SYNTHESIS, AFFINITY PROFILE AND FUNCTIONAL ACTIVITY OF MUSCARINIC ANTAGONISTS WITH A 1-METHYL-2-(2,2-ALKYLARYL-1,3-OXATHIOLAN-5-YL)PYRROLIDINE STRUCTURE. JOURNAL OF MEDICINAL CHEMISTRY, vol. 50, pp. 1409-1413, ISSN:0022-2623 DOI

Scapecchi, Serena; Matucci, Rosanna; Bellucci, Cristina; Buccioni, M.; Dei, Silvia; Guandalini, Luca; Martelli, Cecilia; Manetti, Dina; Martini, Elisabetta; Marucci, G.; Nesi, Marta; Romanelli, MARIA NOVELLA; Teodori, Elisabetta; Gualtieri, Fulvio (2006). Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, pp. 1925-1931, ISSN:0022-2623 DOI

L. GUANDALINI; E. MARTINI; M. ROMANELLI; F. DALLATOMASINA (2006). Metodo per rimuovere un gruppo protettivo di un composto tetrazolico N-protetto. S.I.M.S. S.r.l.- Società Italiana Medicinali Scandicci

S. Scapecchi; R. Matucci; C. Bellucci; M. Buccioni; S. Dei; L. Guandalini; C. Martelli; D. Manetti; E. Martini; G. Marucci; M. Nesi; M.N.Romanelli; E. Teodori; P. Angeli (2006). Sintesi e valutazione farmacologica di derivati furanici e tetraidrofuranici a potenziale azione muscarinica. In: XXII Congresso Nazionale della Società Chimica Italiana, Firenze, 10-15 Settembre 2006, Società Chimica Italiana, pp. 197-197.

E. Martini; C. Ghelardini; D. Manetti; S. Dei; L. Guandalini; F. Gualtieri; S. Scapecchi; E. Teodori; M.N. Romanelli (2006). Design, synthesis and preliminary pharmacological evaluation of 1,4-diaminobenzenes and 1,4-diaminocyclohexanes as cognition modulators. In: XXII Congresso Nazionale della Società Chimica Italiana, Firenze, 10-15 Settembre 2006, Società Chimica Italiana, pp. 195-195.

Elisabetta Teodori; Silvia Dei; Fulvio Gualtieri; Dina Manetti; Cecilia Martelli; Maria Novella Romanelli; Serena Scapecchi; Arlette Garnier-Suillerot (2006). Optimization and structure-activity relationships of a new class of MDR reverters. In: XXII congresso Nazionale della Società Chimica Italiana SCI 2006, Firenze, 10-15 settembre 2006, Società Chimica Italiana, pp. 164-164.

S. Dei; C. Bellucci; M. Buccioni; M. Ferraroni; L. Guandalini; D. Manetti; E. Martini; G. Marucci; R. Matucci; M. Nesi; M.N. Romanelli; S. Scapecchi; E. Teodori (2006). Antagonisti muscarinici a struttura 1,3-ossatiolano-2-pirrolidinica. In: XXII Congresso Nazionale della Società Chimica Italiana, Firenze, 10-15 Settembre 2006, Società Chimica Italiana, pp. 188-188.

L. GUANDALINI; E. MARTINI; M. ROMANELLI; F. DALLATOMASINA (2006). Intermediate compounds for the preparation of angiotensin II antagonists. Numero: PCT/IT2007/000031 S.I.M.S.S.r.l.- Società Italiana Medicinali Scandicci

L.Guandalini; E.Martini; P.Gratteri; C.Ghelardini; K.Varani; M.Romanelli (2006). Design, synthesis and binding affinity of new nicotinic ligands. ARKIVOC, vol. viii, pp. 50-65, ISSN:1551-7004

M. ROMANELLI; N. GALEOTTI; C. GHELARDINI; D. MANETTI; E. MARTINI; F. GUALTIERI (2006). Pharmacological characterization of DM232 (unifiram) and DM235 (sunifiram), new potent cognition-enhancers. CNS DRUG REVIEWS, vol. 12, pp. 39-52, ISSN:1080-563X DOI

E. Teodori; C. Martelli; D. Manetti; S. Dei; M.N.Romanelli; S. Scapecchi; M. Salerno; A.Garnier-Suillerot; F. Gualtieri (2006). Isomeric N,N-(dicyclohexane-4-ol)amine aryl esters: the discovery of a new class of highly potent and efficacious Pgp-dependent MDR inhibitors. In: CNIO Cancer Conference Medicinal Chemistry in Oncology, Madrid, 2-4 Ottobre, Centro National de Investigaciones Oncologicas, pp. 34-34.

Martini, Elisabetta; Ghelardini, Carla; Bertucci, C.; Dei, Silvia; Gualtieri, Fulvio; Guandalini, Luca; Manetti, Dina; Scapecchi, Serena; Teodori, Elisabetta; Romanelli, MARIA NOVELLA (2005). Enantioselective synthesis and preliminary pharmacological evaluation of the enantiomers of unifiram (DM232), a potent cognition-enhancing agent. MEDICINAL CHEMISTRY, vol. 1, pp. 473-480, ISSN:1573-4064

Dei, Silvia; Angeli, P.; Bellucci, Cristina; Buccioni, M.; Gualtieri, Fulvio; Marucci, G.; Manetti, Dina; Matucci, Rosanna; Romanelli, MARIA NOVELLA; Scapecchi, Serena; Teodori, Elisabetta (2005). Muscarinic subtype affinity and functional activity profile of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)pyrrolidine and 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine derivatives.. BIOCHEMICAL PHARMACOLOGY, vol. 69, pp. 1637-1645, ISSN:0006-2952 DOI

F. GUALTIERI; L. GUANDALINI; D. MANETTI; E. MARTINI; M. ROMANELLI (2005). COGNITION-ENHANCING DRUGS IN MILD COGNITIVE IMPAIRMENT (MCI) AND ALZHEIMER'S DISEASE (AD): AN UPDATE[1]. MEDICINAL CHEMISTRY REVIEWS-ONLINE, vol. 2, pp. 471-487, ISSN:1567-2034 DOI

Teodori, Elisabetta; Dei, Silvia; GARNIER SUILLEROT, A.; Gualtieri, Fulvio; Manetti, Dina; Martelli, Cecilia; Romanelli, MARIA NOVELLA; Scapecchi, Serena; Sudwan, P.; Salerno, M. (2005). Exploratory chemistry toward the identification of a new class of MDR reverters inspired by pervilleine and verapamil models. JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, pp. 7426-7436, ISSN:0022-2623 DOI

Elisabetta Teodori; Silvia Dei; Arlette Garnier-Suillerot; Fulvio Gualtieri; Luca Guandalini; Dina Manetti; Cecilia Martelli; Maria Novella Romanelli; Serena Scapecchi (2005). Exploratory Chemistry toward the identification of new classes of MDR reverters. In: Joint Meeting on Medicinal Chemistry, Vienna Austria, 20-23 June 2005, Oesterreichische Pharmazeutische Gesellschaft, vol. 73, pp. S164-S164.

Guandalini, Luca; Martini, Elisabetta; Dei, Silvia; Manetti, Dina; Scapecchi, Serena; Teodori, Elisabetta; Romanelli, MARIA NOVELLA; Varani, K.; Greco, G.; Spadola, L.; Novellino, E. (2005). Design of novel nicotinic ligands through 3D database searching. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 13, pp. 799-807, ISSN:0968-0896 DOI

Romanelli, MARIA NOVELLA; Cerbai, Elisabetta; Dei, Silvia; Guandalini, Luca; Martelli, Cecilia; Martini, Elisabetta; Scapecchi, Serena; Teodori, Elisabetta; Mugelli, Alessandro (2005). Design, synthesis and preliminary biological evaluation of zatebradine analogues as potential blockers of the hyperpolarization-activated current. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 13, pp. 1211-1220, ISSN:0968-0896 DOI

A. Laurenzana; C. Cellai; A. Vannucchi; A. Pancrazzi; M. Romanelli; F. Paoletti (2005). WEB-2086 and WEB-2170 trigger apoptosis in both ATRA-sensitive and -resistant promyelocytic leukemia cells and greatly enhance ATRA differentiation potential. LEUKEMIA, vol. 19, pp. 390-395, ISSN:0887-6924

D. Manetti; L. Di Cesare Mannelli; S. Dei; N. Galeotti; C. Ghelardini; M. Romanelli; S. Scapecchi; E. Teodori; A. Pacini; A. Bartolini; F. Gualtieri (2005). Design, synthesis and preliminary pharmacological evaluation of a set of small molecules that directly activate Gi proteins.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, pp. 6491-6503, ISSN:0022-2623 DOI

L.Guandalini; E.Martini; C.Martelli; M.N.Romanelli; K.Varani (2005). Rigid Analogs of DMPP As Probes For The Nicotinic Receptors. IL FARMACO, vol. 60, pp. 99-104, ISSN:0014-827X

S. SCAPECCHI; E. MARTINI; D. MANETTI; C. GHELARDINI; C. MARTELLI; S. DEI; N. GALEOTTI; L. GUANDALINI; M. ROMANELLI; E. TEODORI (2004). Structure-activity relationship studies on unifiram (DM232) and sunifiram (DM235), two novel and potent cognition enhancing drugs. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 12, pp. 71-85, ISSN:0968-0896 DOI

S. SCAPECCHI; C. MARTELLI; P. ANGELI; C. BELLUCCI; M. BUCCIONI; S. DEI; F. GUALTIERI; G. MARUCCI; R. MATUCCI; M. ROMANELLI; E. TEODORI (2004). MOLECULAR MODULATION OF MUSCARINIC ANTAGONISTS. SYNTHESIS AND PHARMACOLOGICAL PROFILE OF 2,2-DIPHENYL-2-ETHYLTHIOACETIC AND 3,3-DIPHENYL-3-ETHYLTHIOPROPIONIC ACID DERIVATIVES CHARACTERIZED BY A DIPEPTIDE SPACER. LETTERS IN DRUG DESIGN & DISCOVERY, vol. 1, pp. 91-96, ISSN:1570-1808

D. Manetti; L.Di Cesare Mannelli; S. Dei; N. Galeotti; C. Ghelardini; M.N. Romanelli; S. Scapecchi; E. Teodori; A. Bartolini; F. Gualtieri (2004). Progettazione, sintesi e valutazione farmacologica preliminare di attivatori diretti delle proteine Gi. In: XVII Convegno Nazionale della Divisione di Chimica Farmaceutica della Società Chimica Italiana, Pisa, 6-10 Settembre 2004, Società Chimica Italiana, pp. 249-249.

L. GUANDALINI; E. MARTINI; F. GUALTIERI; M. ROMANELLI; K. VARANI (2004). DESIGN, SYNTHESIS AND PRELIMINARY PHARMACOLOGICAL EVALUATION OF RIGID ANALOGUES OF THE NICOTINIC AGONIST 1,1-DIMETHYL-4-PHENYLPIPERAZINIUM IODIDE (DMPP). ARKIVOC, vol. V, pp. 286-300, ISSN:1551-7012

E. Martini; C. Ghelardini; D. Manetti; S. Dei; L. Guandalini; C. Martelli; S. Scapecchi; E. Teodori; M.N.Romanelli (2004). Sintesi chirale e valutazione farmacologica preliminare degli enantiomeri di DM232 e MC68, due azabiciclononanoni modulatori dei processi cognitivi. In: XVII Convegno Nazionale della Divisione di Chimica Farmaceutica della Società Chimica Italiana, Pisa, 6-10 Settembre 2004, Società Chimica Italiana, pp. 182-182.

Serena Scapecchi; Cecilia Martelli; Elisabetta Martini; Cristina Bellucci; Silvia Dei; Fulvio Gualtieri; Rosanna Matucci; Maria Novella Romanelli; Elisabetta Teodori (2004). Synthesis and pharmacological characterization of diastereomeric and enantiomeric isomers of 1-methyl-2-(2-methyl-1,3-oxathiolane-5-yl)pyrrolidine 3-sulfoxides and their methyl iodides. In: XVIIIth Symposium on Medicinal Chemistry, Copenhagen and Malmoe, 15-19 agosto 2004, J . R. Prous, vol. 29, Suppl. A, pp. P238-P238.

Maria Novella Romanelli; Silvia Dei; Fulvio Gualtieri; Luca Guandalini; Dina manetti; Serena Scapecchi; Elisabetta Teodori; Orazio Prezzavento; Giuseppe Ronsisvalle (2004). Phenylalkyltropanyl esters and ethers of phenoxypropionic acid as novel sigma receptor ligands. In: XVIIIth International Symposium on Medicinal Chemistry, Copenhagen, Demark & Malmo, Sweden, 15-19 August 2004, J.R.Prous Drugs of the Future, vol. 29, Suppl. A, pp. 328-328.

P. GRATTERI; M. ROMANELLI; G. CRUCIANI; C. BONACCINI; F. MELANI (2004). GRIND-derived pharmacophore model for a series of α-tropanyl derivative ligands of the sigma-2 receptor. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, vol. 18, pp. 361-374, ISSN:0920-654X DOI Accesso ONLINE all'editore

E. Teodori; S. Dei; F. Gualtieri; D. Manetti; C. Martelli; M.N.Romanelli; S. Scapecchi; A. Garnier-Suillerot (2004). Progettazione e sintesi di analoghi della Pervilleina A: una nuova classe di inibitori della Multidrug Resistance (MDR). In: XVII Convegno Nazionale della Divisione di Chimica Farmaceutica della Società Chimica Italiana, Pisa, 6-10 Settembre 2004, Società Chimica Italiana, pp. 250-250.

Teodori, Elisabetta; Baldi, Elisabetta; Dei, Silvia; Gualtieri, Fulvio; Romanelli, MARIA NOVELLA; Scapecchi, Serena; Bellucci, Cristina; Ghelardini, Carla; Matucci, Rosanna (2004). Design, synthesis and preliminary pharmacological evaluation of 4-aminopiperidine derivatives as N-type calcium channel blockers active on pain and neuropathic pain. JOURNAL OF MEDICINAL CHEMISTRY, vol. 47, pp. 6070-6081, ISSN:0022-2623, American Chemical Society:1155 Sixteenth Street Northwest:Washington, DC 20036:(800)227-5558, EMAIL: service@acs.org, INTERNET: http://www.pubs.acs.org, Fax: (614)447-3671: DOI

D. MANETTI; E. MARTINI; C. GHELARDINI; S. DEI; N. GALEOTTI; L. GUANDALINI; M. ROMANELLI; S. SCAPECCHI; E. TEODORI; A. BARTOLINI; F. GUALTIERI (2003). 4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, pp. 2303-2306, ISSN:0960-894X DOI

Dei, Silvia; Bellucci, Cristina; Buccioni, M.; Ferraroni, Marta; Gualtieri, Fulvio; Guandalini, Luca; Manetti, Dina; Matucci, Rosanna; Romanelli, MARIA NOVELLA; Scapecchi, Serena; Teodori, Elisabetta (2003). Synthesis and Cholinergic Affinity of Diastereomeric and Enantiomeric Isomers of 1-Methyl-2-(2-methyl-1,3-dioxolan-4-yl)-pyrrolidine, 1-Methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine and of Their Iodomethylates. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11, pp. 3153-3164, ISSN:0968-0896 DOI

F. GUALTIERI; M. ROMANELLI (2003). Cholinergic nicotinic receptors: Competitive ligands, allosteric modulators, and their potential application. MEDICINAL RESEARCH REVIEWS, vol. 23, pp. 393-426, ISSN:0198-6325

N.GALEOTTI; C.GHELARDINI; A.PITTALUGA; A. PUGLIESE; A.BARTOLINI; D.MANETTI; M.ROMANELLI; F.GUALTIERI (2003). AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram).. NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY, vol. 368, pp. 538-545, ISSN:0028-1298

Serena Scapecchi; Cecilia Martelli; Elisabetta Martini; Cristina Bellucci; Silvia Dei; Fulvio Gualtieri; Luca Guandalini; Rosanna Matucci; Maria Novella Romanelli; Elisabetta Teodori (2003). Highly chiral muscarinic ligands: synthesis and affinity of diastereomeric and enantiomeric isomers of 1-methyl-2-(2-methyl-1,3-oxathiolane-5-yl)pyrrolidine 3-sulfoxides and their methyl iodides. In: Polish-Austrian-German-Hungarian-Italian Joint Meeting on Medicinal Chemistry, Cracovia (PL), 15-18 ottobre 2003, Jagellonian University, Krakow (PL), pp. 57-57.

Serena Scapecchi; Piero Angeli; Cristina Bellucci; Silvia Dei; Fulvio Gualtieri; Cecilia Martelli; Gabriella Marucci; Rosanna Matucci; Maria Novella Romanelli; Elisabetta Teodori (2003). Molecular modulation of muscarinic antagonists. Synthesis and pharmacological profile of 2,2-diphenyl-2-ethylthioacetic acid and 3,3-diphenyl-3-ethylthiopropionic acid derivatives characterized by a dipeptide spacer. In: 14th Camerino-Noordwijkerhout Symposium Ongoing Progress in the Receptor Chemistry, Camerino (MC), 7-11 settembre 2003, Università degli studi di Camerino, pp. 88-88.

Elisabetta Teodori; Elisabetta Baldi; Cristina Bellucci; Silvia Dei; Carla Ghelardini; Fulvio Gualtieri; Rosanna Matucci; Maria Novella Romanelli; Serena Scapecchi (2003). Design, synthesis and preliminary pharmacological evaluation of alkylderivatives of 4-aminopiperidine as N-type calcium channels blockers. In: XXI Congresso Nazionale della Società Chimica Italiana SCI2003, Torino, 22-27 giugno 2003, Società Chimica Italiana, pp. FA-CO-021-FA-CO-021.

L. Guandalini; M.N. Romanelli; S. Scapecchi; D. Manetti; C. Martelli; E. Martini; S. Dei; E. Teodori; F. Gualtieri; K. Varani; P.A.Borea (2003). Design, synthesis and pharmacological evaluation of some frozen-analogues of DMPP. In: Polish-Austrian-German-Hungarian-Italian Joint Meeting on medicinal chemistry, Krakow, Poland, 15-18 October 2003, Polish Austrian German Hungarian Italian Chemical Society, pp. 56-56.

F. GUALTIERI; D. MANETTI; M. N. ROMANELLI; C. GHELARDINI (2002). Design and study of piracetam-like nootropics, controversial members of the problematic class of cognition-enhancing drugs. CURRENT PHARMACEUTICAL DESIGN, vol. 8, pp. 125-138, ISSN:1381-6128

Ghelardini C.;Galeotti N.;Gualtieri F.;Romanelli M.;Bucherelli C.;Baldi E.;Bartolini A. (2002). DM235 (sunifiram): a novel nootropic with potential as a cognitive enhancer. NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY, vol. 365, pp. 419-426, ISSN:0028-1298 DOI

L. GUANDALINI; S. DEI; F. GUALTIERI; M.N. ROMANELLI; S. SCAPECCHI; E. TEODORI; K. VARANI (2002). Synthesis of Hexahydro-[2]pyrindine(=Hexahydrocyclopenta[c]pyridine) Derivatives as Conformationally Restricted Analogs of the Nicotinic Ligands Arecolone and Isoarecolone. HELVETICA CHIMICA ACTA, vol. 85, pp. 96-107, ISSN:0018-019X

L. GUANDALINI; S. DEI; D. MANETTI; M.N. ROMANELLI; S. SCAPECCHI; E. TEODORI; K. VARANI (2002). Synthesis and pharmacological evaluation of some (pyridyl)cyclopropylmethyl amines and their methiodides as nicotinic receptor ligands.. IL FARMACO, vol. 57, pp. 487-496, ISSN:0014-827X

O. PREZZAVENTO; F. GUALTIERI; A. MARRAZZO; M.N. ROMANELLI; G. RONSISVALLE; E. TEODORI (2002). Sigma Receptors Binding Profile of a Series of Analgesic Tropane Derivatives.. ARCHIV DER PHARMAZIE, vol. 335, pp. 1-5, ISSN:0365-6233

Silvia Dei; Cristina Bellucci; Michela Buccioni; Marta Ferraroni; Fulvio Gualtieri; Luca Guandalini; Dina Manetti; Rosanna Matucci; Maria Novella Romanelli; Serena Scapecchi; Katia Varani; Elisabetta Teodori (2002). Sintesi e affinità per i recettori colinergici degli stereoisomeri della 1-metil-2-(2-metil-1,3-diossolan-4-il)pirrolidina, della 1-metil-2-(2-metil-1,3-ossatiolan-5-il)pirrolidina e dei loro iodometilati. In: XVI convegno nazionale della Divisione di Chimica Farmaceutica, Società Chimica Italiana, Sorrento, 18-22 settembre 2002, Società Chimica Italiana Divisione di Chimica Farmaceutica, pp. 39-39.

C. Ghelardini; N. Galeotti; F. Gualtieri; D. Manetti; M.N. Romanelli; A. Bartolini (2002). The novel nootropic drugs DM232 (Unifiram) and DM235 (Sunifiram) ameliorate memory impairment in mice and rats. In: COST Action D13 Workshop new molecules toward human health care, Firenze, 17-20 Aprile 2002, Università degli Studi di Firenze, pp. 52-52.

Serena Scapecchi; Silvia Dei; Fulvio Gualtieri; Dina Manetti; Elisabetta Martini; Maria Novella Romanelli; Elisabetta Teodori; Carla Ghelardini (2002). Molecular simplification of DM232 and DM235, two new potent cognition enhancers. In: XVIIth International Symposium on Medicinal Chemistry, Barcelona (Spain), 1-5 Settembre 2002, J.R.Prous Drugs of the Future, vol. 27, Suppl. A, pp. 442-442.

Elisabetta Teodori; Silvia Dei; Fulvio Gualtieri; Dina Manetti; Maria Novella Romanelli; Serena Scapecchi; Elisabetta Baldi; Carla Ghelardini (2002). Synthesis and biological evaluation of 4-amino piperidines as N-type calcium channel blockers. In: XVIIth International Symposium on Medicinal Chemistry, Barcelona, Spain, 1-5 Settembre 2002, J.R.Prous Drugs of the Future, vol. 27, Suppl. A, pp. 473-473.

P. GRATTERI; M. ROMANELLI; C. BONACCINI (2002). GRID INDEPENDENT DESCRIPTORS (GRIND) IN THE STUDY OF THE S-RECEPTOR SUBTYPE SELECTIVITY.. In: XVIIth International Symposium on Medicinal Chemistry, Barcelona (Spain), 1-5 September, 2002, vol. SUPPL A, pp. 257-257.

Maria Novella Romanelli; Silvia Dei; Fulvio Gualtieri; Dina Manetti; Serena Scapecchi; Elisabetta Teodori; Orazio Prezzavento; Giuseppe Ronsisvalle (2002). Benzyl-tropanyl esters and ethers of phenoxypropionic acid as novel sigma receptor ligands. In: XVIIth International Symposium on Medicinal Chemistry, Barcelona, Spain, 1-5 Settembre 2002, J.R.Prous Drugs of the Future, vol. 27, Suppl. A, pp. 419-419.

Maria Novella Romanelli; Silvia Dei; Fulvio Gualtieri; Luca Guandalini; Dina Manetti; Serena Scapecchi; Elisabetta Teodori; Piero Andrea Borea; Katia Varani (2002). Design, Synthesis and pharmacological evaluation of heterocyclic nicotinic ligands. In: 8th IBN SINA International Conference on pure and Applied Heterocyclici Chemistry, Luxor, Egypt, 16-19 February 2002, Chemistry Department Faculty of Science, pp. 47 IL-37-47 IL-37.

P. Gratteri; G. Cruciani; S.Scapecchi; M.N. Romanelli (2001). Independent Descriptors (GRIND) in the rational design of muscarinic antagonists. In: 13th European Symposium on Quantitative Structure-Activity Relationships, Dusseldorf, August 27 - September 1, 2000, Prous Science, pp. 241-243, ISBN:9788481241761

Scapecchi, Serena; Marucci, G.; Matucci, Rosanna; Angeli, P.; Bellucci, Cristina; Buccioni, M.; Dei, Silvia; Gualtieri, Fulvio; Manetti, Dina; Romanelli, MARIA NOVELLA; Teodori, Elisabetta (2001). Structure-activity relationships in 2,2-diphenyl-2-ethylthioacetic acid esters: unexpected agonistic activity in a series of muscarinic antagonists.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 9, pp. 1165-1174, ISSN:0968-0896

Romanelli, MARIA NOVELLA; Manetti, Dina; Scapecchi, Serena; Borea, P.; Dei, Silvia; Bartolini, Alessandro; Ghelardini, Carla; Gualtieri, Fulvio; Guandalini, Luca; Varani, K. (2001). Structure-affinity relationships of a unique nicotinic ligand: N1-dimethyl-N4-phenylpiperazinium iodide (DMPP). JOURNAL OF MEDICINAL CHEMISTRY, vol. 44, pp. 3946-3955, ISSN:0022-2623 DOI

P. GRATTERI; G. CRUCIANI; S. SCAPECCHI; M. ROMANELLI (2001). GRID INDEPENDENT DESCRIPTORS (GRIND) IN THE RATIONAL DESIGN OF MUSCARINIC ANTAGONISTS.. In: H. D. HÖLTJE AND W. SIPPL. RATIONAL APPROACHES TO DRUG DESIGN., pp. 241-243, Barcelona- Philadelphia: PROUS Science, ISBN:9788481241761.

L. Guandalini; M.N. Romanelli; S. Scapecchi; D. Manetti; S. Dei; E. Teodori; F. Gualtieri; C. Ghelardini; A. Bartolini; K. Varani; P.A. Borea (2001). Design, synthesis and pharmacological evaluation of DMPP analogues to explore the Nicotinic receptor binding site. In: 13th Noordwijkerhout-Camerino Symposium Trends in drug research, Noordwijkerhout, the Netherlands, 6-11 May 2001, Division Pharmacochemistry of the Royal Netherlands Chemical Society, European Federation for Medicinal Chemistry, pp. 57-57.

E. Teodori; S. Dei; A. Garnier-Suillerot; P. Gratteri; F. Gualtieri; D. Manetti; M.N. Romanelli; S. Scapecchi (2000). Structure activity relationships in a series of potent MDR inhibitors. In: XVIth International Symposium on Medicinal Chemistry, Bologna, 18-22 Settembre 2000, Italian Chemical Society Division of Medicinal Chemistry, pp. 523-523.

Elisabetta Teodori; Silvia Dei; Arlette Garnier-Suillerot; Paola Gratteri; Fulvio Gualtieri; Dina Manetti; Maria Novella Romanelli; Serena Scapecchi (2000). Relazioni Struttura Attività nell'ambito di un potente Inibitore della MDR. In: XX Congresso Nazionale della Società Chimica Italiana, Rimini, 4-9 Giugno 2000, Società Chimica Italiana, pp. FR-OR014-FR-OR014.

D. MANETTI; C. GHELARDINI; A. BARTOLINI; C. BELLUCCI; S. DEI; N. GALEOTTI; F. GUALTIERI; M.N. ROMANELLI; S. SCAPECCHI; E. TEODORI (2000). Design, synthesis and preliminary pharmacological evaluation of 1,4-diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic drugs.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, pp. 1969-1974, ISSN:0022-2623 DOI

Dina Manetti; Carla Ghelardini; Alessandro Bartolini; Cristina Bellucci; Silvia Dei; Nicoletta Galeotti; Fulvio Gualtieri; Maria Novella Romanelli; Serena Scapecchi; Elisabetta Teodori (2000). 1,4-Diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic drugs. In: 7th IBN SINA International Conference on pure and applied heterocyclic chemistry, Alexandria, Egypt, 25-28 March 2000, Chemistry Department Faculty of Science, pp. IL-51-IL-51.

D. Manetti; C. Ghelardini; A. Bartolini; C. Bellucci; S. Dei; N. Galeotti; F. Gualtieri; M.N. Romanelli; S Scapecchi; E. Teodori (2000). 1,4-Diazabicyclo[4.3.0]nonan-9-ones and 1,4-diamidopiperazines as new classes of highly potent nootropic drugs. In: XVIth International Symposium on Medicinal Chemistry, Bologna, 18-22 Settembre 2000, Italian Chemical Society Division of Medicinal Chemistry, pp. 395-395.

D. MANETTI; C. GHELARDINI; A. BARTOLINI; S. DEI; N. GALEOTTI; F. GUALTIERI; M. N. ROMANELLI; E. TEODORI (2000). Molecular simplification of 1,4-diazabicyclo[4.3.0]nonan-9-ones gives piperazine derivatives that maintain high nootropic activity. JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, pp. 4499-4507, ISSN:0022-2623 DOI

C. GHELARDINI; N. GALEOTTI; M. ROMANELLI; F. GUALTIERI; A. BARTOLINI (2000). PHARMACOLOGICAL CHARACTERIZATION OF THE NOVEL ACH RELEASER A-TROPANYL 2-(4-BROMOPHENYL)PROPIONATE (PG-9).. CNS DRUG REVIEWS, vol. 6, pp. 63-78, ISSN:1080-563X

P. GRATTERI; G. CRUCIANI; S. SCAPECCHI; M. ROMANELLI; F. MELANI (2000). 3D-QSAR, GRID DESCRIPTORS AND CHEMOMETRIC TOOLS IN THE DEVELOPMENT OF SELECTIVE ANTAGONIST OF MUSCARINIC RECEPTOR.. In: K. GUNDERTOFTE AND F.S. JORGENSEN (EDS.). MOLECULAR MODELING AND PREDICTION OF BIOACTIVITY, pp. 334-335, New York: Kluwer Academic/Plenum Publisher, ISBN:9780306462177.

E. TEODORI; S. DEI; P. QUIDU; R. BUDRIESI; A. CHIARINI; A. GARNIER-SUILLEROT; F. GUALTIERI; D. MANETTI; M.N. ROMANELLI; S. SCAPECCHI (1999). Design, synthesis, and in vitro acivity of catamphiphilic reverters of multidrug resistance: discovery of selective, highly efficacious chemosensitizer with potency in the nanomolar range. JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, pp. 1687-1697, ISSN:0022-2623

P. Angeli; C. Bellucci; S. Dei; F. Gualtieri; D. Manetti; G. Marucci; R. Matucci; M.N.Romanelli; S. Scapecchi; E. Teodori (1999). Unexpected agonistic activity in a series of muscarinic antagonists. In: 12th Camerino-Noordwijkerhout Symposium Receptor chemistry towards the third millennium, Camerino, 5-9 Settembre 1999, Università degli Studi di Camerino, pp. 104-104.

E. TEODORI; D. ETTORI; A. GARNIER-SUILLEROT; F. GUALTIERI; D. MANETTI; M.N. ROMANELLI; S. SCAPECCHI (1999). "Synthesis and binding properties of photoactivable Biotin-conjugated verapamil derivatives for the study of P-170 glycoprotein". BIOORGANIC & MEDICINAL CHEMISTRY, vol. 7, pp. 1873-1880, ISSN:0968-0896

M.N. Romanelli; S. Dei; F. Gualtieri; L. Guandalini; D. Manetti; S. Scapecchi; E.Teodori (1999). Synthetic approaches to obtain new potential nicotinic agonists with a 5-oxo and 7-oxo-hexahydropyrindine nucleus. In: Italian-Hungarian-Polish Joint Meeting on Medicinal Chemistry, Taormina, 28 Settembre-1 Ottobre 1999, Società Chimica Italiana, pp. 204-204.

E. Teodori; S. Dei; F. Gualtieri; D. Manetti; M.N.Romanelli; S.Scapecchi (1999). 4-(2-Pyrrolidinyl)-1,3-dioxolane derivatives as ligands for muscarinic and nicotinic receptors. In: Italian-Hungarian-Polish Joint Meeting on Medicinal Chemistry, Taormina, 28 Settembre-1 Ottobre 1999, Società Chimica Italiana, pp. 205-205.

C. GHELARDINI; I. MIZUMA; F. GUALTIERI; A. BARTOLINI; N. GALEOTTI; M. ROMANELLI; E. TEODORI (1999). Binding Profiles of a Series of 2-Arylpropionic Acid Esters on Cloned Human Muscarinic Receptors Subtypes (m1-m5) and Their Relationship to Nootropic Activity. ARZNEIMITTEL-FORSCHUNG, vol. 49 (I), pp. 483-488, ISSN:0004-4172

D. MANETTI; A. BARTOLINI; P. BOREA; C. BELLUCCI; S. DEI; C. GHELARDINI; F. GUALTIERI; M. ROMANELLI; S. SCAPECCHI; E. TEODORI; K. VARANI (1999). Hybridized and isosteric analogs of N1-acetyl-N4-dimethyl-piperazinium iodide (ADMP) and N1-phenyl-N4-dimethyl-piperazinium iodide (DMPP) with central nicotinic action. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 7, pp. 457-465, ISSN:0968-0896

E. Teodori; S. Dei; P. Quidu; R. Budriesi; A. Chiarini; A. Garnier-Suillerot; F. Gualtieri; D. Manetti; M.N.Romanelli; S.Scapecchi (1998). Design, synthesis, and in vitro activity of catamphiphilic reverters of multidrug resistance (MDR). The discovery of a selective, highly efficacious chemosensitizer with potency in the low nanomolar range. In: XIV Convegno Nazionale Divisione di Chimica Farmaceutica Società Chimica Italiana, Salsomaggiore Terme-Parma, 21-25 Settembre 1998, Società Chimica Italiana, pp. 191-191.

D. Manetti; A. Bartolini; P.A.Borea; C. Bellucci; S. Dei; C. Ghelardini; F. Gualtieri; M.N. Romanelli; S. Scapecchi; E. Teodori; K.Varani (1998). Hybridized and isosteric analogs of N1-acetyl-N4-dimethylpiperazinium iodide (ADMP), N1-phenyl-N4-dimethylpiperazinium iodide (DMPP) with central nicotinic action. In: XIV Convegno Nazionale Divisione di Chimica Farmaceutica Società Chimica Italiana, Salsomaggiore Terme-Parma, 21-25 Settembre 1998, Società Chimica Italiana, pp. 92-92.

E. Teodori; S. Dei; P. Quidu; R. Budriesi; A. Chiarini; A. Garnier-Suillerot; F. Gualtieri; D. Manetti; M.N. Romanelli; S. Scapecchi (1998). Design, synthesis and in vitro activity of catamphiphilic reverters of multidrug resistance (MDR). The discovery of a selective, highly efficacious chemosensitizer with potency in the low nanomolar range. In: XVth EFMC International Symposium on Medicinal Chemistry, Edinburgh, Scotland, 6-10 Settembre 1998, European Federation for Medicinal Chemistry, pp. 139-139.

S. SCAPECCHI; A. GIORGI; C. BELLUCCI; S. DEI; C. GHELARDINI; D. MANETTI; M. ROMANELLI; E. TEODORI (1998). FURTHER STRUCTURE-ACTIVITY RELATIONSHIPS IN THE SERIES OF TROPANYL ESTERS ENDOWED WITH POTENT ANTINOCICEPTIVE ACTIVITY. IL FARMACO, vol. 53, pp. 764-772, ISSN:0014-827X

M.N. Romanelli; A. Castagnoli; F. Gualtieri; D. Manetti; S. Scapecchi; E. Teodori; E.Novellino; G. Greco (1998). Development of a comprehensive model of interaction with the central nicotinic receptor using CoMFA. In: XIV Convegno Nazionale Divisione di Chimica Farmaceutica Società Chimica Italiana, Salsomaggiore Terme-Parma, 21-25 Settembre 1998, Società Chimica Italiana, pp. 91-91.

M.N. Romanelli; F. Gualtieri; D. Manetti; S. Scapecchi; E. Teodori; E. Novellino; G. Greco (1998). Development of a comprehensive model of interaction with the central nicotinic receptor using CoMFA. In: 12th European Symposium on Quantitative Structure- Activity Relationships, Copehhagen, Denmark, 23-28 Agosto 1998, European Federation for Medicinal Chemistry, pp. P56-P56.

D. Manetti; A. Bartolini; P.A.Borea; C. Bellucci; S. Dei; C. Ghelardini; F. Gualtieri; M.N. Romanelli; S. Scapecchi; E. Teodori; K. Varani (1998). Hybridized and isosteric analogs of N1-acetyl-N4-dimethylpiperazinium iodide (ADMP), N1-phenyl-N4-dimethylpiperazinium iodide (DMPP) with central nicotinic action. In: XVth EFMC Internatinal Symposium on Medicinal Chemistry, Edinburgh, Scotland, 6-10 Settembre 1998, Royal Society of Chemistry, European Federation for Medicinal Chemistry, pp. 138-138.

Silvia Dei; Cristina Bellucci; Fulvio Gualtieri; Dina manetti; Maria Novella Romanelli; Serena Scapecchi; Elisabetta Teodori; Alessandro Bartolini; Carla Ghelardini (1997). Differential analgesic activity of the enantiomers of atropine derivatives does not correlate with their muscarinic subtype selectivity. In: First Italian-Swiss Meeting on Medicinal Chemistry, Torino, 23-26 Settembre 1997, Italian Chemical Society e New Swiss Chemical Society Section of Medicinal Chemistry, pp. 57 A3-57 A3.

F. GUALTIERI; M. ROMANELLI; E. TEODORI (1997). DISEGNO E SINTESI DI FARMACI E MEZZI DI INDAGINE FARMACOLOGICA. BOLOGNA: CLUEB

S. DEI; A. BARTOLINI; C. BELLUCCI; C. GHELARDINI; F. GUALTIERI; D. MANETTI; M. N. ROMANELLI; S. SCAPECCHI; E. TEODORI (1997). DIFFERENTIAL ANALGESIC ACTIVITY OF THE ENANTIOMERS OF ATROPINE DERIVATIVES DOES NOT CORRELATE WITH THEIR MUSCARINIC SUBTYPE SELECTIVITY. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 32, pp. 595-605, ISSN:0223-5234

S. SCAPECCHI; P. ANGELI; S. DEI; C. GHELARDINI; F. GUALTIERI; G. MARUCCI; F. PAPARELLI; M. ROMANELLI; E. TEODORI (1997). SAR STUDIES ON THE POTENT AND SELECTIVE MUSCARINIC ANTAGONIST 2-ETHYLTHIO-2,2-DIPHENYLACETIC ACID N,N-DIETHYLAMINOETHYL ESTER. ARCHIV DER PHARMAZIE, vol. 330, pp. 122-128, ISSN:0365-6233

C. GHELARDINI; F. GUALTIERI; M. ROMANELLI; P. ANGELI; G. PEPEU; M. GIOVANNINI; F. CASAMENTI; P. MALMBERG; A. GIOTTI; A. BARTOLINI (1997). STEREOSELECTIVE INCREASE IN CHOLINERGIC TRANSMISSION BY R-(+)- HYOSCYAMINE. NEUROPHARMACOLOGY, vol. 36, pp. 281-294, ISSN:0028-3908 DOI

D. MANETTI; P. BOREA; C. GHELARDINI; F. GUALTIERI; M. N. ROMANELLI; S. SCAPECCHI; G. VALLE (1997). REDUCED-FLEXIBILITY HYBRIDS OF THE NICOTINIC AGONISTS 1,1-DIMETHYL-4-ACETYLPIPERAZINIUM IODIDE AND 2-(DIMETHYLAMINO)METHYL-5-CYCLOPENTANONE METHIODIDE. MEDICINAL CHEMISTRY RESEARCH, vol. 7, pp. 301-312, ISSN:1054-2523

C. GHELARDINI; N. GALEOTTI; F. GUALTIERI; M. ROMANELLI; A. BARTOLINI (1997). ANTINOCICEPTION INDUCED BY SM32 DEPENDS ON CENTRAL CHOLINERGIC MECHANISM. PHARMACOLOGICAL RESEARCH, vol. 35, pp. 141-147, ISSN:1043-6618 DOI

Maria Novella Romanelli; Silvia Dei; Fulvio Gualtieri; Dina Manetti; Serena Scapecchi; Elisabetta Teodori; Alberto Chiarini; Roberta Budriesi (1997). Semirigid Cyclopropyl derivatives of the Calcium-Antagonist verapamil. In: First Italian-Swiss Meeting on Medicinal Chemistry, Torino, 23-26 Settembre 1997, Italian Chemical Society e New Swiss Chemical Society Section of Medicinal Chemistry, pp. 76 A22-76 A22.

S. DEI; C. BELLUCCI; C. GHELARDINI; M. ROMANELLI; S. SPAMPINATO (1996). SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL PROFILE OF TROPICAMIDE ENANTIOMERS. LIFE SCIENCES, vol. 58, pp. 2147-2153, ISSN:0024-3205

Elisabetta Teodori; Silvia Dei; Fulvio Gualtieri; Dina manetti; Maria Novella Romanelli; Serena Scapecchi; Samlee Mankhetkorn; Arlette Garnier-Suillerot (1996). Progettazione e sintesi di molecole marcate e fotosensibili per lo studio della proteina P170 (MDR). In: XIII Convegno Nazionale di Chimica Farmaceutica della SCI, Paestum (SA), 23-27 Settembre 1996, Società Chimica Italiana Divisione di Chimica Farmaceutica, pp. 44 Atti C-F8-44 Atti C-F8.

S. Dei; E. Teodori; F. Gualtieri; D. Manetti; M.N.Romanelli; S.Scapecchi; R.Budriesi; A.Chiarini; A. Garnier-Suillerot (1996). Sintesi e proprietà farmacologiche di analoghi del verapamile attivi come chemiosensibilizzatori. In: XIII Convegno Nazionale Divisione di Chimica Farmaceutica Società Chimica Italiana, Paestum, 23-27 Settembre 1996, Società Chimica Italiana Divisione di Chimica Farmaceutica, pp. 138-138.

M.N. ROMANELLI; A.BARTOLINI; C. BERTUCCI; S. DEI; C. GHELARDINI; M.G. GIOVANNINI; F. GUALTIERI; G. PEPEU; S. SCAPECCHI; E. TEODORI (1996). Synthesis and Enantioselectivity of the Enantiomers of PG9 and SM21, New Potent Analgesic and Cognition-Enhancing Drugs. CHIRALITY, vol. 8, pp. 225-233, ISSN:0899-0042 DOI

F. GUALTIERI; E. TEODORI; M. ROMANELLI (1996). THE FROZEN ANALOG APPROACH IN MEDICINAL CHEMISTRY. In: M. I. CHOUDHARY. PROGRESS IN MEDICINAL CHEMISTRY,VOL. 1, pp. 271-318, HARWOOD ACADEMIC PUBLISHERS: HARWOOD ACADEMIC PUBLISHERS.

D. MANETTI; M. ROMANELLI; A. BARTOLINI; S. DEI; C. GHELARDINI; F. GUALTIERI; R. MATUCCI; S. SCAPECCHI; E. TEODORI (1996). REDUCED FLEXIBILITY ANALOGS OF ANALGESIC AND COGNITION-ENHANCING A-TROPANYL ESTERS. ARCHIV DER PHARMAZIE, vol. 329, pp. 105-111, ISSN:0365-6233

P. DOLARA; G. MONETI; G. PIERACCINI; M. ROMANELLI (1996). CHARACTERIZATION OF THE ACTION ON CENTRAL OPIOID RECEPTORS OF FURANOEUDESMA-1,3-DIENE, A SESQUITERPENE EXTRACTED FROM MYRRH. PHYTOTHERAPY RESEARCH, vol. 10, pp. S81-S83, ISSN:0951-418X

Maria Novella Romanelli; Cristina Bellucci; Silvia Dei; Fulvio Gualtieri; Dina Manetti; Serena Scapecchi; Elisabetta Teodori; Carla Ghelardini; Alessandro Bartolini; Piero Borea (1996). Progettazione, Sintesi e studio di molecular modeling di nuovi ligandi nicotinici. In: XIII Convegno Nazionale Divisione di Chimica Farmaceutica, Paestum (SA), 23-27 Settembre 1996, Società Chimica Italiana Divisione di Chimica Farmaceutica, pp. 67 Atti C-M1-67 Atti C-M1.

P. Dolara; C. Luceri; C. Ghelardini; C. Monserrat; S. Aiolli; F. Luceri; M. Lodovici; S. Menichetti; M. Romanelli (1996). Analgesic effects of myrrh. NATURE, vol. 379, pp. 29-29, ISSN:0028-0836

M. ROMANELLI; A. BARTOLINI; C. BERTUCCI; S. DEI; C. GHELARDINI; M. GIOVANNINI; F. GUALTIERI; G. PEPEU; S. SCAPECCHI; E. TEODORI; (1996). Chiral synthesis and pharmacological evaluation of the enantiomers of SM32, a new analgesic and cognition-enhancing agent.. CHIRALITY, vol. 8, pp. 579-584, ISSN:0899-0042 DOI

Silvia Dei; Cristina Bellucci; Carla Ghelardini; Maria Novella Romanelli; Serena Scapecchi; Santi Spampinato; Elisabetta Teodori (1995). Pharmacological profile of the enantiomers of tropicamide. In: 10th Camerino-Noordwijkerhout Symposium Perpectives in Receptor Research, Camerino, 10-14 settembre 1995, Università degli studi di Camerino, pp. 100-100.

F. GUALTIERI; A. BARTOLINI; C. BERTUCCI; S. DEI; C. GHELARDINI; M.G. GIOVANNINI; A. GIOTTI; G. PEPEU; M.N. ROMANELLI; S. SCAPECCHI; E. TEODORI. (1995). Alpha-tropanyl esters that increase central ACh release: enantioselectivity studies support a double mechanism of action.. LIFE SCIENCES, vol. 56, pp. 1015-1015, ISSN:0024-3205

Silvia Dei; Cristina Bellucci; Alessandro Bartolini; Carla Ghelardini; Fulvio Gualtieri; Maria Novella Romanelli; Serena Scapecchi; Elisabetta Teodori (1995). Attività analgesica e antimuscarinica ed enantioselettività dei quattro isomeri del tropato del 3-chinuclidinolo messe a confronto con gli enantiomeri della iosciamina. In: Convegno Nazionale su orientamenti e metodologie in chimica farmaceutica, organica e bioorganica, Numana (AN), 2-6 giugno 1995, Società Chimica Italiana, pp. O40-O40.

Maria Novella Romanelli; Alessandro Bartolini; Carlo Bertucci; Silvia Dei; Carla Ghelardini; Maria Grazia Giovannini; Fulvio Gualtieri; Giancarlo Pepeu; Serena Scapecchi; Elisabetta Teodori (1995). Stereospecific synthesis and pharmacological evaluation of the enantiomers of SM32, a new central ACh releaser. In: 10th Camerino-Noordwijkerhout Symposium Perspectives in Receptor Research, Camerino, 10-14 settembre 1995, Università degli studi di Camerino, pp. 99-99.

M. ROMANELLI; H. HOELTJE; S. SCAPECCHI (1995). THEORETICAL INVESTIGATIONS ON ANTIMUSCARINIC ETHYLTHIO AND ETHOXY DERIVATIVES OF ADIPHENINE AND 4-DAMP. QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS, vol. 14, pp. 126-143, ISSN:0931-8771

F. GUALTIERI; S. DEI; D. MANETTI; M. ROMANELLI; S. SCAPECCHI; E. TEODORI (1995). THE MEDICINAL CHEMISTRY OF ALZHEIMER'S AND ALZHEIMER-LIKE DISEASES WITH EMPHASIS ON THE CHOLINERGIC HYPOTHESIS. IL FARMACO, vol. 50, pp. 489-503, ISSN:0014-827X

Dei, Silvia; Bellucci, Cristina; Gualtieri, Fulvio; Romanelli, MARIA NOVELLA; Scapecchi, Serena; Teodori, Elisabetta; Bartolini, Alessandro; Ghelardini, Carla (1995). ANALGESIC, ANTIMUSCARINIC ACTIVITY AND ENANTIOSELECTIVITY OF THE FOUR ISOMERS OF 3-QUINUCLIDINYL TROPATE AS COMPARED WITH THE ENANTIOMERS OF HYOSCYAMINE. IL FARMACO, vol. 50, pp. 303-309, ISSN:0014-827X

Voigt, W.; Romanelli, MARIA NOVELLA; Lemoine, H.; Mannhold, R.; Dei, Silvia; Teodori, Elisabetta; Gualtieri, Fulvio (1995). STRUCTURAL DEPENDENCE OF THE ALLOSTERIC INTERACTION OF SEMI-RIGID VERAPAMIL ANALOGUES WITH DIHYDROPYRIDINE-BINDING IN KITTEN HEART. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 291, pp. 255-264, ISSN:0014-2999

Serena Scapecchi; Piero Angeli; Silvia Dei; Fulvio Gualtieri; Gabriella Marucci; Fiorella Paparelli; Maria Novella Romanelli; Elisabetta Teodori (1995). Further SAR studies in a series of antimuscarinic antagonists related to the esters of 2,2-diphenyl-2-alkylthioacetic acids. In: II Congresso Congiunto Italiano-Spagnolo di Chimica Farmaceutica, Ferrara, 30 agosto-3 settembre 1995, Società Chimica Italiana Divisione di Chimica Farmaceutica, pp. P169-P169.

F. GUALTIERI; C. BOTTALICO; A. CALANDRELLA; S. DEI; M. GIOVANNONI; S. MEALLI; M. ROMANELLI; S. SCAPECCHI; E. TEODORI; N. GALEOTTI; C. GHELARDINI; A. GIOTTI; A. BARTOLINI (1994). Presynaptic Cholinergic Modulators as Potent Cognition Enhancers and Analgesic Drugs. 2. 2-Phenoxy-, 2-(phenylthio)- and 2-(phenylamino)alkanoic Acid Esters. JOURNAL OF MEDICINAL CHEMISTRY, vol. 37, pp. 1712-1719, ISSN:0022-2623 DOI

Gualtieri, Fulvio; Conti, G.; Dei, Silvia; Giovannoni, MARIA PAOLA; Nannucci, F.; Romanelli, MARIA NOVELLA; Scapecchi, Serena; Teodori, Elisabetta; Fanfani, L.; Ghelardini, Carla; Giotti, Alberto; Bartolini, Alessandro (1994). Presynaptic Cholinergic Modulators as Potent Cognition Enhancers and Analgesic Drugs. 1. Tropic and 2-Phenylpropionic Acid Esters. JOURNAL OF MEDICINAL CHEMISTRY, vol. 37, pp. 1704-1711, ISSN:0022-2623

M.N. Romanelli; A. Bartolini; S. Dei; C. Ghelardini; F. Gualtieri; D. Manetti; R. Matucci; S. Scapecchi; E. Teodori (1994). Analoghi a ridotta flessibilità molecolare di nuovi farmaci ad azione nootropa ed analgesica. In: XI Convegno Nazionale Divisione di Chimica Farmaceutica Società Chimica Italiana, Bari, 2-5 Ottobre 1994, Società Chimica Italiana Divisione di Chimica Farmaceutica, pp. 96-96.

S. SCAPECCHI; P. ANGELI; S. DEI; F. GUALTIERI; G. MARUCCI; R. MORICONI; F. PAPARELLI; M. ROMANELLI; E. TEODORI (1994). DIALKYLAMINOALKYL ESTERS OF 2,2-DIPHENYL-2-ALKYLTIOACETIC ACIDS: A NEW CLASS OF POTENT AND FUNCTIONALLY SELECTIVE MUSCARINIC ANTAGONISTS. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 2, pp. 1061-1074, ISSN:0968-0896

M. ROMANELLI; S. DEI; S. SCAPECCHI; E. TEODORI; F. GUALTIERI; R. BUDRIESI; R. MANNHOLD (1994). SEMI-RIGID ANALOGUES OF THE CALCIUM ANTAGONIST VERAPAMIL: A MOLECULAR MODELLING STUDY. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, vol. 8, pp. 123-134, ISSN:0920-654X

E. TEODORI; S. DEI; M. ROMANELLI; S. SCAPECCHI; F. GUALTIERI; R. BUDRIESI; A. CHIARINI; H. LEMOINE; R. MANNHOLD (1994). SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF VERAPAMIL ANALOGS WITH RESTRICTED MOLECULAR FLEXIBILITY. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 29, pp. 139-148, ISSN:0223-5234

Teodori E; Dei S; Romanelli M; Scapecchi S; Gualtieri F; Angeli P; Marucci G; Matucci R. (1994). 1,3-oxathiolane muscarinic ligands modified at the cationic head.. IL FARMACO, vol. 49, pp. 305-312, ISSN:0014-827X

Werner Voigt; Horst Lemoine; Raimund Mannhold; Maria Novella Romanelli; Silvia Dei; Elisabetta Teodori; Fulvio Gualtieri (1994). Structural dependence of the allosteric interaction of semi-rigid verapamil analogues with DHP-binding in kitten heart. In: 6th International Symposium on pharmacological control of Calcium and Potassium Homeostasis, Firenze, 4-6 ottobre 1994, Fondazione Giovanni Lorenzini, pp. 44-44.

S. SCAPECCHI; P. ANGELI; S. DEI; F. GUALTIERI;G. MARUCCI; M. ROMANELLI; E. TEODORI (1993). N,N-DIETHYLAMINOETHANOL AND N-METHYL-4-PIPERIDINOL ESTERS OF 2,2-DIPHENYL-2-ETHYLTHIOACETIC ACID AS POTENT AND SELECTIVE MUSCARINIC ANTAGONISTS. PHARMACEUTICAL AND PHARMACOLOGICAL LETTERS, vol. 2, pp. 220-223, ISSN:0939-9488

Galeotti, N; Fanfani, L; Meonin, P; Ghelardini, C; Giotti, A; Gualtieri, F; Romanelli, Mn; Bartolini, A (1993). Effect of 5-HT4 agonists metoclopramide and Compound 1 on learning and memory. In: XXI International Congress of Neurovegetative Research, Elsevier, vol. 43, pp. 78-79.

Romanelli, MARIA NOVELLA; Ghelardini, Carla; Dei, Silvia; Matucci, Rosanna; Mori, Francesca; Scapecchi, Serena; Teodori, Elisabetta; Bartolini, Alessandro; Galli, Alessandro; Giotti, Alberto; Gualtieri, Fulvio (1993). SYNTHESIS AND BIOLOGICAL ACTIVITY OF A SERIES OF ARYL TROPANYL ESTERS AND AMIDES CHEMICALLY RELATED TO 1H-INDOLE-3-CARBOXYLIC ACID ENDO 8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL ESTER. ARZNEIMITTEL-FORSCHUNG, vol. 43 (II), pp. 913-918, ISSN:0004-4172

C. EABORN; M. ROMANELLI (1993). ANCHIMERIC ASSISTANCE BY THE GAMMA-N3 AND GAMMA-NCS GROUPS IN SOLVOLYSIS OF (ME3SI)2C(SIME2N3)(SIME2BR) AND (ME3SI)2C(SIME2NCS)(SIME2BR). JOURNAL OF ORGANOMETALLIC CHEMISTRY, vol. 451, pp. 45-52, ISSN:0022-328X

S. DEI; M. ROMANELLI; S. SCAPECCHI; E. TEODORI; F. GUALTIERI; A. CHIARINI; W. VOIGT; H. LEMOINE (1993). VERAPAMIL ANALOGUES WITH RESTRICTED MOLECULAR FLEXIBILITY: SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF THE FOUR ISOMERS OF ALPHA-[1-[3-[N-[1-[2-(3,4-DIMETHOXYPHENYL)ETHYL]]-N-METHYLAMINO]CYCLOHEXYL]]-ALPHA-ISOPROPYL-3,4-DIMETHOXYBENZENEACETONITRILE. JOURNAL OF MEDICINAL CHEMISTRY, vol. 36, pp. 439-445, ISSN:0022-2623

M.N. ROMANELLI; E. TEODORI; S. SCAPECCHI; S. DEI (1992). UNEXPECTED REACTIONS OF 2-NITRO-FLUORENE-9-CARBOXYLIC ACID. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 27, pp. 53-56, ISSN:0223-5234

C. GHELARDINI; A. GIOTTI; F. GUALTIERI; R. MATUCCI; M. ROMANELLI; S. SCAPECCHI; E. TEODORI; A. BARTOLINI (1992). PRESYNAPTIC AUTO- AND HETERO-RECEPTORS IN THE CHOLINERGIC REGULATION OF PAIN. In: 8. TRENDS IN RECEPTOR RESEARCH, pp. 95-114, ELSEVIER SCIENCE PUBLISHERS B. V. AMSTERDAM: P. ANGELI, U. GULINI, W. QUAGLIA.

F. GUALTIERI; E. TEODORI; M. ROMANELLI (1991). PFEIFFER'S RULE AND EUDISMIC ANALYSIS: STRESSING THE HOMOGENEITY OF DATA. In: C. SILIPO, A. VITTORIA. QSAR: RATIONAL APPROACHES TO THE DESIGN OF BIOACTIVE COMPOUNDS, pp. 451-456, AMSTERDAM: ELSEVIER SCIENCE PUBLISHERS B. V..

M. N. ROMANELLI; E. TEODORI; S. SCAPECCHI; S. DEI; R. BUDRIESI; A. CHIARINI (1991). SYNTHESIS AND CARDIOVASCULAR PROPERTIES OF FLUORENYL DERIVATIVES RELATED TO VERAPAMIL. IL FARMACO, vol. 46, pp. 1121-1138, ISSN:0014-827X

F. GUALTIERI; M. ROMANELLI; S. SCAPECCHI; E. TEODORI; A. BARTOLINI; L. FANTETTI; C. GHELARDINI; A. GIOTTI (1991). MUSCARINIC PRESYNAPTIC AUTORECEPTORS AND MUSCARINIC POSTSYNAPTIC RECEPTORS HAVE OPPOSITE STEREOCHEMICAL REQUIREMENTS. MEDICINAL CHEMISTRY RESEARCH, vol. 1, pp. 52-58, ISSN:1054-2523

S. DEI; M. N. ROMANELLI; S. SCAPECCHI; E. TEODORI; A. CHIARINI; F. GUALTIERI (1991). VERAPAMIL ANALOGUES WITH RESTRICTED MOLECULAR FLEXIBILITY. JOURNAL OF MEDICINAL CHEMISTRY, vol. 34, pp. 2219-2225, ISSN:0022-2623

F. GUALTIERI; M. ROMANELLI; E. TEODORI (1990). EUDISMIC ANALYSIS OF A SERIES OF MUSCARINIC LIGANDS CARRYING A 1,3-OXATHIOLANE NUCLEUS. CHIRALITY, vol. 2, pp. 79-84, ISSN:0899-0042

F. GUALTIERI; M. ROMANELLI; E. TEODORI (1989). ON THE SITE OF INTERACTION OF SOME MUSCARINIC AGONISTS AND COMPETITIVE ANTAGONISTS. IL FARMACO, vol. 44, pp. 897-909, ISSN:0014-827X

M.N. ROMANELLI; F. GUALTIERI; P. ANGELI; M.T. PICCHIO (1989). Enantioselectivity of muscarinic antagonists. Isomeric 2-Cyclohexyl-2-phenyl-5-((dimethylamino)methyl)-1,3-oxathiolane 3-Oxide Methiodides. JOURNAL OF MEDICINAL CHEMISTRY, vol. 32, pp. 2269-2273, ISSN:0022-2623, American Chemical Society:1155 Sixteenth Street Northwest:Washington, DC 20036:(800)227-5558, EMAIL: service@acs.org, INTERNET: http://www.pubs.acs.org, Fax: (614)447-3671:

M. ROMANELLI; F. GUALTIERI; R. MANNHOLD; A. CHIARINI (1989). A SEARCH FOR CALCIUM CHANNELS ACTIVATORS IN THE VERAPAMIL SERIES. IL FARMACO, vol. 44, pp. 449-464, ISSN:0014-827X

M.N. ROMANELLI; E. TEODORI; F. GUALTIERI; P. ANGELI; L. BRASILI (1988). ENANTIOSELECTIVITY OF MUSCARINIC ANTAGONISTS. 2,2-DICYCLOHEXYL-5-[(DIMETHYLAMINO)METHYL]-1,3-OXATHIOLANE METHIODIDES AND RELATED 3-OXIDES. JOURNAL OF MEDICINAL CHEMISTRY, vol. 31, pp. 1698-1702, ISSN:0022-2623

M.N. ROMANELLI; F. GUALTIERI; G. VALLE; L. BRASILI; P. ANGELI (1988). Enantioselectivity of muscarinic antagonists. Isomeric 2-cyclohexyl-2-phenyl-5-((dimethylamino)methyl)-1,3-oxathiolane methiodides. JOURNAL OF MEDICINAL CHEMISTRY, vol. 31, pp. 1703-1708, ISSN:0022-2623, American Chemical Society:1155 Sixteenth Street Northwest:Washington, DC 20036:(800)227-5558, EMAIL: service@acs.org, INTERNET: http://www.pubs.acs.org, Fax: (614)447-3671:

F. GUALTIERI; P. ANGELI; L. BRASILI; M. GIANNELLA; M. PICCHIO; M. ROMANELLI; E. TEODORI (1988). ENANTIOSELECTIVITY OF CHIRAL CHOLINERGIC AGONISTS AND ANTAGONISTS CARRYING A 1,3-OXATHIOLANE NUCLEUS. In: C. MELCHIORRE AND M.GIANNELLA. RECENT ADVANCES IN RECEPTOR CHEMISTRY, pp. 235-249, AMSTERDAM: ELSEVIER SCIENCE PUB. B.V..

P. ANGELI; D. BACCHIOCCHI; M. GIANNELLA; M. PIGINI; M. ROMANELLI (1988). MOLECULAR REQUIREMENTS FOR ANTIMUSCARINIC ACTIVITY IN THE 1,3-OXATHIOLANES. DRUG DESIGN AND DELIVERY, vol. 2, pp. 263-272, ISSN:0884-2884

C. EABORN; P. LICKISS; S. NAJIM; M. ROMANELLI (1986). 1,3-MIGRATION OF CHLORIDE AND AZIDE SUBSTITUENTS WITHIN ORGANOSILICON CATIONS, AND ANCHIMERIC ASSISTANCE BY THE AZIDO GROUP. JOURNAL OF ORGANOMETALLIC CHEMISTRY, vol. 315, pp. C5-C8, ISSN:0022-328X

C. EABORN; A.I. AL-WASSIL; M. ROMANELLI (1986). PREPARATION AND SOME REACTIONS OF THE COMPOUNDS OF THE TYPE (ME3SI)2C(SIME2OME)(SIME2X). ANCHIMERIC ASSISTANCE BY THE METHOXY GROUP. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS II, vol. .., pp. 1363-1365, ISSN:0300-9580

C. EABORN; P. LICKISS; S. NAJIM; M. ROMANELLI (1985). UNIMOLECULAR ALCOHOLYSIS OF ORGANOSILICON HALIDES OF THE TYPE (ME3SI)2C(SIME2OME)(SIR2X). ANCHIMERIC ASSISTANCE BY AND MIGRATION OF THE OME GROUP. JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS, vol. .., pp. 1754-1755, ISSN:0022-4936

C. EABORN; M. N. ROMANELLI (1984). THE FIRST SILICON THIOCYANATE. JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS, vol. .., pp. 1616-1617, ISSN:0022-4936 DOI Accesso ONLINE all'editore

A. RICCI; M. ROMANELLI; M. TADDEI; G. SECONI; A. SHANZER (1983). RING-OPENING REACTIONS OF LACTONES WITH ALKYLAMINOSTANNANES: A NEW REGIOSELECTIVE ROUTE TO W-STANNOXYAMIDES AND RELATED COMPOUNDS. SYNTHESIS, vol. .., pp. 319-322, ISSN:0039-7881

M. Fiorenza; A. Ricci; M. Romanelli; M. Taddei; P. Dembech; G. Seconi (1982). Regioselective functionalisation of the Delta alfa,beta-butenolide ring via group IV-B organometallics. HETEROCYCLES, vol. 19, pp. 2327-2329, ISSN:0385-5414

Maria Novella ROMANELLI

Biography

Date of birth: July 5, 1957

Nationality: Italian

Marital status: Married

Current position: Full professor of Medicinal Chemistry

Maria Novella ROMANELLI

Curriculum

EDUCATION

1982: Honour degree in Pharmaceutical Chemistry and Technologies at University of Florence, with a thesis in organic chemistry. Supervisor: Prof. Alfredo Ricci

1985-1988: PhD in Medicinal Chemistry at University of Florence. Title of doctoral dissertation: Synthesis, absolute configuration and enantioselectivity of muscarinic antagonists carrying a 1,3-oxathiolane nucleus. Supervisor: Prof. Fulvio Gualtieri

RESEARCH POSITIONS AND ACADEMIC APPOINTMENTS

1983-1984: postdoctorial fellows at University of Sussex (UK), working at two different research projects on silicon chemistry (Supervisor: Prof. Colin Eaborn).

1989 (January-December): Grant from Tecnofarmaci (Pomezia, Italy) for a research project on the synthesis of selective antagonists for the cholinergic receptors in the CNS.

1989 (December)-1998: research worker at the Faculty of Pharmacy of University of Florence

1998-2001: Associated professor of Medicinal Chemistry, Faculty of Pharmacy, University of Florence

2001-today: Full professor of Medicinal Chemistry, Faculty of Pharmacy (now School of Human Health Sciences), University of Florence

TRAINING AND RESEARCH EXPERIENCES

1986 (July and August) and 1987 (July): stages at the Physiologisches Insitut III, University of Düsseldorf (DE) working at a research project in Molecular Pharmacology. Supervisor: Prof. Raimund Mannhold

1988 (September – November): stage at the Royal Danish School of Pharmacy, Copenhaghen (DK), working at a project in molecular modelling. Supervisor: Prof. Flemming Jorgensen

1993 (July-December): CNR grant at the Freie Universität, Berlin (DE) working at a project in molecular modelling. Supervisor: Prof. Hans-Dieter Höltje

ACADEMIC ACTIVITY

2007-2014: Coordinator of the degree course in Pharmaceutical Chemistry and Technology, Faculty of Pharmacy (now School of Human Health Sciences), University of Florence.

2009-2014: member of the scientific board of the European School of Medicinal Chemistry (Urbino) for PhD students.

2010-2013: Dean deputy at the Faculty of Pharmacy (University of Florence)

2013-2018: member of the committee for “Patent and intellectual property”, University of Florence.

PRIMARY AREAS OF RESEARCH INTERESTS

Design and synthesis of biologically active compounds, such as Ion channels blockers, HDAC inhibitors, Carbonic anhydrase modulators, Cholinergic modulators (muscarinic and nicotinic), Multidrug Resistance Inhibitors, Cognitive enhancers.

SCIENTIFIC SOCIETIES

Member of the Italian Chemical Society

REVIEWING EXPERIENCES

Reviewer for the following journals: ACS Medicinal Chemistry Letters, Bioorganic and Medicinal Chemistry, Bioorganic and Medicinal Chemistry Letters, Canadian Journal of Physiology and Pharmacology, Chirality, Current Medicinal Chemistry, European Journal of Medicinal Chemistry, European Journal of Organic Chemistry, European Journal of Pharmaceutical Sciences, Expert Opinion on Therapeutic Patents, Future Medicinal Chemistry, International Journal for Environmental Research and Public Health, Journal of Enzyme Inhibition and Medicinal Chemistry, Journal of Medicinal Chemistry, Letters in Organic Chemistry, Synthetic Communications.

Grant reviewer for: Science Foundation Ireland, Fondation por la Recherche Medical (France), Fondecyt (Chile), University of Bologna, University of Milan.

PUBLICATIONS AND PATENTS

Co-author of 4 patent applications.

Co-author of >160 articles/reviews/book chapters

Maria Novella ROMANELLI

Interest

Design and synthesis of biologically active compounds in the field of

Cholinergic modulators (muscarinic and nicotinic)

Cognitive enhancers

Multidrug Resistance Inhibitors

HDAC and dual HDAC-BRD4 inhibitors

Carbonic anhydrase modulators

Ion channels blockers

Maria Novella ROMANELLI

Note

2007-2014: Coordinator of the degree course in Pharmaceutical Chemistry and Technology, Faculty of Pharmacy (now School of Human Health Sciences), University of Florence.

2009-2014: member of the scientific board of the European School of Medicinal Chemistry (Urbino) for PhD students.

2010-2013: Dean deputy at the Faculty of Pharmacy (University of Florence)

2013-2018: member of the committee for “Patent and intellectual property”, University of Florence

Area riservata