Inizio delle lezioni di CHIMICA ORGANICA SUPERIORE per la Magistrale in SCIENZE CHIMICHE

Le lezioni di Chimica Organica Superiore inizieranno martedì 22 settembre. L’orario sarà quello riportato sul sito del Corso di Studi: Martedì e giovedì ore 11:00-13:00 aula 37.

Inizio delle lezioni di CHIMICA ORGANICA I per CTF

Le lezioni di Chimica Organica I per CTF inizieranno lunedì 21 settembre. L’orario sarà quello riportato sul sito del Corso di Studi: Lunedì 16:00-18:30 aula 41, mercoledì 08:30-11:30 aula 01, giovedì 16:00-18:30 aula 103.

Tutti i giorni previo appuntamento

Prof Stefano Menichetti, nato A cerreto Guidi (FI), il 14 marzo 1960

Indirizzo: Dipartimento di Chimica “Ugo Schiff” - DICUS, Università di Firenze. Via della Lastruccia, 3-13, I-50019 Sesto Fiorentino, Firenze, Italy. Tel. +39-055-4573535. Email: stefano.menichetti@unifi.it

ORCID: 0000-0001-6745-7484

Educazione

1987: Laurea in Chimica, massimo dei voti con lode, Università di Firenze.

Lavoro

- 2005 - ad oggi: Professore ordinario di Chimica Organica, Dipartimento di Chimica “U. Schiff”, Università di Firenze.

- 2002-2005: Professore associato di Chimica Organica, Dipartimento di Chimica Organica “U. Schiff”, Università di Firenze.

- 1999-2002: Professore associato di Chimica Organica, Dipartimento di Chimica Organica e Biologica, Università di Messina.

-1991: Postdoctoral Fellow, Dipartimento di Chimica, Università di Sheffield (UK) supervisore C. J. M. Stirling.

- 1990-1999: Ricercatore di Chimica Organica, Dipartimento di Chimica Organica “U. Schiff”, Università di Firenze

- 1988-1990: Insegnante di Chimica, scuole medie superiori.

- 1987-1988: Servizio militare.

Didattica

L’attività didattica intesa come lezioni frontali è iniziata nel 1994, da allora ha tenuto 2/3 corsi di chimica organica di base ed avanzata per ogni anno accademico. E’ stato relatore di oltre 50 tesi sperimentali in Chimica e CTF e tutore o co-tutore di 8 PhD in scienze chimiche.

Responsabilità Istituzionali (dal 2003)

- 2020 – a oggi: Membro del Collegio dei Docenti della Scuola di Dottorato in Scienze Chimiche;

- 2019-2022: Membro del Comitato Scientifico del GICO (Gruppo Interdivisionale di Organometallica della Società Chimica Italiana - GICO-SCI);

- 2015-2022: Presidente del Consiglio di Corso di Laura in CTF (Chimica e Tecnologia Farmaceutiche);

- 2014-2021: Membro del Comitato di Indirizzo e Autovalutazione (CIA) del DICUS;

- 2010-2014: Responsabile per la VQR (2014-2017) del DICUS;

- 2010-2012: Delegato del Dipartimento e Presidente del Comitato della Biblioteca di Scienze dell’Università di Firenze;

- 2004-2010: Delegato del Dipartimento nel Comitato della Biblioteca di Scienze dell’Università di Firenze.

Ricerca

Lo studio di nuove metodologie sintetiche stereocontrollate, catalitiche ed eco-compatibili, utili alla preparazione di derivati con applicazioni in chimica fine e farmaceutica o in scienza dei materiali è il target della moderna chimica organica sintetica ed il principale obiettivo della nostra ricerca. In particolare, ci interessiamo della messa a punto di nuove metodologie sintetiche e della preparazione di nuove molecole attraverso la sintesi stereoselettiva mediata dallo zolfo e le reazioni di etero Diels-Alder. Le recenti acquisizioni, rese possibili dall’abilità nel costruire molecole includono: i) la preparazione di eterocicli solforati a nota attività biologica, ii) la sintesi di nuovi derivati polifenolici ad azione antiossidante multi-difesa e iii) la preparazione di molecole per la terapia e la diagnosi tumorale. Più recentemente abbiamo iniziato ad interessanti della preparazione e delle proprietà di sistemi eteroelicenici. La ricerca è documentata da più di 140 pubblicazioni su riviste internazionali “peer review”, 2 brevetti e più di 150 comunicazioni a congressi nazionali e internazionali.

Collaborazioni

Antiossidanti

- Prof. Jacek Ścianowski, Nicolaus Copernicus University in Torun, (Poland);

- Proff. Luca Valgimigli, and Riccardo Amorati, Department of Organic Chemistry “G. Ciamician”, University of Bologna, (Italy);

- Prof. Enrico Marcantoni, School of Chemistry, University of Camerino, (Italy);

- Dr. Teresa Iantomasi, Department of Biomedical, Experimental and Clinical Sciences "M. Serio", University of Florence (Italy);

- Dr. Paola Stagnaro, Institute of Chemical Sciences and Technologies (SCITEC) "G. Natta", Italian National Research Council, Genoa (Italy).

Prodotti di interesse farmaceutico

- Proff. Luisa Bracci, and Chiara Falciani Department of Molecular Biology, University of Siena, (Italy);

- Proff. Piero Procacci, Gabriella Caminati, and Marco Fragai, Department of Organic Chemistry ‘U. Schiff’, University of Florence (Italy);

Eliceni

- Prof. Giovanna Longhi, University of Brescia (Italy);

- Prof. Claudio Villani, University ‘La Sapienza’, Roma, (Italy);

- Proff. Roberta Sessoli, and Matteo Mannini, Department of Organic Chemistry ‘U. Schiff’, University of Florence (Italy);

- Prof. Ron Naaman, Weizmann Institute of Science, Tel Aviv (Israel).

Conferenze a Invito (2018-2022)

1. XVIII International Symposium on Selected Problems of Chemistry of Acyclic and Cyclic Heteroorganic Compounds, Czestochowa, Poland, November 22, 2018: “Synthesis and selected properties of heterohelicenes: A new twist on our chemistry”.

2. ^th International Symposium Advanced in the Chemistry of Heteroorganic Compounds, Lodz, Poland, November 23, 2018: “Synthesis and selected properties of heterohelicenes: A new twist on our chemistry”.
3. ^th International Conference on the Chemistry of Selenium and Tellurium (ICCST-14), Cagliari, Italy, June 3-7, 2019: “Selenium nucleophiles and Sulfur electrophiles: An exciting synthetic combination”

4. . 20th Symposium “Scientific Days of the Consortium CINMPIS” Messina 7-8 september 2021: “Synthesis of [n]heterohelicenes: A modern twist in our chemistry”.

5. XIIIth International Mini-Symposium ‘Cycloaddition Reactions – Theory and Practice’ The Jena-Lodz ‘Institutspartnerschaft’ Workshop. December 10, 2021: “Synthesis of thia-bridged triarylamine[4]-heterohelicenes: A modern twist in our chemistry”.
6. 29^th International Symposium on the Organic Chemistry of Sulfur – ISOCS29 – Guelph –Canada  July 17-22, 2022 “Thia-Bridged Triarylamine[4]Helicenes: Sulfur Synergism for Stereoselective Synthesis and Smart Materials”.
7. ^th Workshop of the Selenium and Sulfur Redox and Catalysis Network - WSeS-10 - November 25-26 2022, Niterói, Rio de Janeiro, Brazil: “Selenium nucleophiles and Sulfur electrophiles: An exciting synthetic combination”.
8. ^th International Conference on the Chemistry of Selenium and Tellurium - ICCST-15 - November 28 - December 02, 2022 - Florianópolis, Brazil “Chalcogens synergism in organic synthesis: A case study”

Indici bibliometrici/attività scientifiche/premi

Più di 165 publicazioni su riviste internazionali con referee e 3 brevetti. Impact Factor medio per pubblicazione degli ultimi 10 anni: IF = 4.13. Scopus H index = 31, citazioni totali = 3200. Google Scholar H index = 35, citazioni totali = 3730.

Membro dell’Editorial Board di ‘Antioxidants’ e di ‘Bioconjugate Chemistry’.

Referee per: Organic Letters, Journal of Organic Chemistry, Chemistry a European Journal, Advanced in Synthesis and Catalysis, Organic and Biomolecular Chemistry, European Journal of Organic Chemistry, Synthesis, Antioxidants, Bioconjugate Chemistry, e molti altri.

Dal 2012 membro del Scientific International Committee of the International Symposium of the Organic Chemistry of Sulfur (ISOCS).

Nel 2020 vincitore del premio per ‘Innovazione in Sintesi Organica’ assegnato dal CINMPIS (Consorzio Interuniversitario Nazionale di ricerca in Metodologie e Processi Innovativi di Sintesi).

Prof. Stefano Menichetti was born on March 14, 1960, in Cerreto Guidi (FI), Italy.

Address: Department of Chemistry “Ugo Schiff” - DICUS, University of Florence. Via della Lastruccia, 3-13, I-50019 Sesto Fiorentino, Firenze, Italy. Tel.  +39-055-4573535. Email: stefano.menichetti@unifi.it

ORCID: 0000-0001-6745-7484

Education

1987: Full march marks and honour degree in Chemistry, University of Florence.

Work

- 2005-present: Full Professor of Organic Chemistry, Department of Chemistry ‘U. Schiff’, University of Florence;

- 2002-2005: Associated Professor of Organic Chemistry, Department of Organic Chemistry ‘U. Schiff’, University of Florence;

- 1999-2002: Associate Professor of Organic Chemistry, Department of Organic and Biological Chemistry, University of Messina;

- 1991: Postdoctoral Fellow, Department of Chemistry, University of Sheffield (UK) with C. J. M. Stirling;

- 1990-1999: Lecturer in Organic Chemistry, Department of Organic Chemistry ‘U. Schiff’ University of Florence-Italy;

- 1988-1990: Chemistry teacher, secondary school.

- 1987-1988: Militar service.

Teaching

Basic and advanced organic chemistry courses (2/3 for academic year) since 1994. Supervisor of more than 50 undergraduate and 8 PhD students.

Institutional responsibilities (since 2003)

- 2020 – present: Member of the board of the PhD in Chemical Sciences University of Florence;

- 2019-2022: Member of the scientific committee of the Interdivisional Group of Organometallic Chemistry (GICO) of SCI;

- 2015-2022: President of the academic 5 years course ‘Chimica e Tecnologia Farmaceutiche – CTF;

- 2014-2021: Member of the Department of Chemistry ‘U. Schiff’ Guidance and Self-Assessment Committee;

- 2010-2014: Responsible for VQR evaluation of the Department of Chemistry ‘U. Schiff’, University of Florence;

- 2010-2012: Department delegate and Presidente of the University of Florence Scientific Library Committee;

- 2004-2010: Department delegate of the University of Florence Scientific Library Committee.

Research interests

Stereocontrolled, catalytic and eco-friendly original synthetic methodologies, and their applications to the preparation of relevant compounds in medicinal chemistry and material science, are the targets of modern organic chemistry and the goals of my research group. Our research is focused on sulfur mediated stereoselective synthesis, hetero Diels-Alder reactions, preparation of new molecular bio-inspired antioxidants as well as nano-supported, and macromolecular antioxidants. In the last years our research interest has focused to the synthesis and properties of [n]heterohelicenes. Recent applications of our ability in “building-up molecules” include: 1) Design and synthesis of bioinspired chalcogen containing (poly)phenolic antioxidants able to exert a potent multi-defence antiradical activity; 2) Design and synthesis of innovative macromolecular additives suitable for the preparation of long lasting polyolefin materials with no risk of contamination in food, pharmaceutical, and biomedical packaging applications; 3) Original access to heterocycles of pharmacological relevance and preparation of new drug-conjugates for cancer targeted diagnosis and therapy; 4) Development of original procedures for the assembly of [n]heterohelicenes and helical shaped derivatives and study of their electronic and chiro optical properties; 5) Synthesis of a new family of geometrically stable [4]heterohelicenes and the corresponding enantiopure radical cations with applications as redox switching and spin filters.

Ongoing collaborations

Antioxidants

- Prof. Jacek Ścianowski, Nicolaus Copernicus University in Torun, (Poland);

- Proff. Luca Valgimigli, and Riccardo Amorati, Department of Organic Chemistry “G. Ciamician”, University of Bologna, (Italy);

- Prof. Enrico Marcantoni, School of Chemistry, University of Camerino, (Italy);

- Dr. Teresa Iantomasi, Department of Biomedical, Experimental and Clinical Sciences "M. Serio", University of Florence (Italy);

- Dr. Paola Stagnaro, Institute of Chemical Sciences and Technologies (SCITEC) "G. Natta", Italian National Research Council, Genoa (Italy).

Medicinal chemistry

- Proff. Luisa Bracci, and Chiara Falciani Department of Molecular Biology, University of Siena, (Italy);

- Proff. Piero Procacci, Gabriella Caminati, and Marco Fragai, Department of Organic Chemistry ‘U. Schiff’, University of Florence (Italy);

Helicenes

- Prof. Giovanna Longhi, University of Brescia (Italy);

- Prof. Claudio Villani, University ‘La Sapienza’, Roma, (Italy);

- Proff. Roberta Sessoli, and Matteo Mannini, Department of Organic Chemistry ‘U. Schiff’, University of Florence (Italy);

- Prof. Ron Naaman, Weizmann Institute of Science, Tel Aviv (Israel).

Invited Lectures (2018-2022)

1. XVIII International Symposium on Selected Problems of Chemistry of Acyclic and Cyclic Heteroorganic Compounds, Czestochowa, Poland, November 22, 2018: “Synthesis and selected properties of heterohelicenes: A new twist on our chemistry”.
2. ^th International Symposium Advanced in the Chemistry of Heteroorganic Compounds, Lodz, Poland, November 23, 2018: “Synthesis and selected properties of heterohelicenes: A new twist on our chemistry”.
3. ^th International Conference on the Chemistry of Selenium and Tellurium (ICCST-14), Cagliari, Italy, June 3-7, 2019: “Selenium nucleophiles and Sulfur electrophiles: An exciting synthetic combination”
4. 20th Symposium “Scientific Days of the Consortium CINMPIS” Messina 7-8 september 2021: “Synthesis of [n]heterohelicenes: A modern twist in our chemistry”.
5. XIIIth International Mini-Symposium ‘Cycloaddition Reactions – Theory and Practice’ The Jena-Lodz ‘Institutspartnerschaft’ Workshop. December 10, 2021: “Synthesis of thia-bridged triarylamine[4]-heterohelicenes: A modern twist in our chemistry”.
6. 29^th International Symposium on the Organic Chemistry of Sulfur – ISOCS29 – Guelph –Canada  July 17-22, 2022 “Thia-Bridged Triarylamine[4]Helicenes: Sulfur Synergism for Stereoselective Synthesis and Smart Materials”.
7. ^th Workshop of the Selenium and Sulfur Redox and Catalysis Network - WSeS-10 - November 25-26 2022, Niterói, Rio de Janeiro, Brazil: “Selenium nucleophiles and Sulfur electrophiles: An exciting synthetic combination”.
8. ^th International Conference on the Chemistry of Selenium and Tellurium - ICCST-15 - November 28 - December 02, 2022 - Florianópolis, Brazil “Chalcogens synergism in organic synthesis: A case study”

Bibliometrics/scientific activity/awards

More than 165 publications on peer review international journals and 3 Patents. Last ten years average IF = 4.13. Scopus H index = 31, total citations = 3200. Google Scholar H index = 35, total citations = 3730.

Member of the Editorial Boards of ‘Antioxidants’ and ‘Bioconjugate Chemistry’.

Referee for: Organic Letters, Journal of Organic Chemistry, Chemistry a European Journal, Advanced in Synthesis and Catalysis, Organic and Biomolecular Chemistry, European Journal of Organic Chemistry, Synthesis, Antioxidants, Bioconjugate Chemistry, and many others.

Since 2012 member of the Scientific International Committee of the International Symposium of the Organic Chemistry of Sulfur (ISOCS).

Winner of the CINMPIS (Consorzio Interuniversitario Nazionale di ricerca in Metodologie e Processi Innovativi di Sintesi) 2020 award for ‘Innovation in Organic Synthesis’.