Personale

Recapiti

Orario di ricevimento

Italiano

Curriculum

Interessi

Pubblicazioni

Insegnamenti

Silvia SELLERI

Ruolo attuale:: Professore Associato
SSD:: CHEM-07/A - Chimica farmaceutica
Afferenza organizzativa:: Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino (NEUROFARBA)

Recapiti

	0554573726
	silvia.selleri(AT)unifi.it

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Inizio delle lezioni Chimica dei Farmaci Innovativi e Biotecnologici (Proff Rovero- Selleri)

La I lezione del corso Chimica dei Farmaci Innovativi e Biotecnologici si terrà martedi 22 Settembre ore 16.00-18.00 in aula 43 dell'Edificio Scienze Farmaceutiche Via Schiff,6 Sesto Fiorentino; il corso proseguirà dal martedì 29 c.m.

Silvia SELLERI

Curriculum

Formazione:

1986 Laurea in Chimica e Tecnologia Farmaceutiche, Università di Firenze. Relatore Prof. F. Bruni.

1989-1991. PhD. in Chimica del Farmaco, Dipartimento di Scienze Farmaceutiche, Università di Firenze.

Attività professionale:

1992-2002, Ricercatore universitario per il gruppo di Discipline C07 (Chimica Farmaceutica) della Facoltà di Farmacia, Dipartimento di Scienze Farmaceutiche, Università di Firenze.

Dal 2003 Professore Associato SSD CHIM/08-Chimica Farmaceutica.

Autrice di 60 pubblicazioni scientifiche e comunicazioni a Convegni Nazionali e Internazionali.

Collaboratore Scientifico (C.S.) dei seguenti progetti di Ricerca:

Collaboratore scientifico dal 1991 ai progetti Sintesi di eterocicli azotati policondensati e valutazione della loro attività biologica finanziati dal MIUR 60%

Collaboratore scientifico a progetti ex 40% dal 1991;

Collaboratore scientifico al progetto 2001-2003, 2003-2005 PRIN Progettazione, sintesi e valutazione farmacologica preliminare di ligandi per i recettori benzodiazepinico centrale, aminoacidergico e colinergico.

Collaboratore scientifico al 2005-2007 PRIN Progettazione, sintesi, caratterizzazione conformazionale ed attività immunologica di nuovi peptidi modificati per lo studio deimeccanismi molecolari delle malattie autoimmuni, l'individuazione di nuovi biomarker di malattia e lo sviluppo di strumenti diagnostici e prognostici innovativi.

Referee di riviste internazionali: Bioorganic and Medicinal Chemistry, Bioorganic and Medicinal Chemistry Letters, Journal of Medicinal Chemistry, Chem. Med. Chem.

Società Scientifiche e organizzazioni a tutela della salute: Dal 1987 socio della SCI, Divisione di Chimica Farmaceutica e Divisione di Chimica Organica, dal 2005 Socio dell'Alzheimer Association americana.

Interessi scientifici: Chimica farmaceutica di composti contenenti il nucleo pirazolico; strategie sintetiche per la realizzazione di composti azotati policondensati contenenti il nucleo pirazolico come ligandi al recettore benzodiazepinico centrale (CBR) e periferico (PBR o TSPO). Realizzazione di traccianti marcati per la diagnosi e stadeazione della malattia di Alzheimer e di alcune patologie neurodegenerative. Sintesi di composti eterociclici per lo studio e limaging delle patologie tumorali e neurodegenerative.

Formation:

1986 Laurea in Chimica e Tecnologia Farmaceutiche, University of Florence. Tutor Prof. F. Bruni.

1989-1991. PhD. in Chimica del Farmaco, Dept. of Pharmaceutical/> Sciences/> University/> of Florence/>/>.

Professional career:

1992-2002, Researcher C07 (Chimica Farmaceutica) in the Faculty of Pharmacy, Dept. of Pharmaceutical Sciences

Since 2003 Associate Professor of Pharmaceutical Chemistry at the Faculty of Pharmacy

Authors and coauthors of 60 scientific papers and and 55 communications at National and International Congresses.

Scientific coworkers (S.C.) of the following research projects:

Since 1991 at the projects: Synthesis of nitrogen policondensed heterocycles and evaluation of biological activities funded by MIUR 60%.

Since 1991 scientific scientific coworker at project funded by MIUR, Italy/>/> ex 40%.

Scientific coworker at PRIN project 2001-2003, 2003-2005 Molecular modelling, synthesis and preliminary pharmacological evaluation of Central Benzodiazepine Receptor, Colinergic and Aminoacidergic ligands.

Scientific coworker of PRIN 2005-2007 funded by MIUR, Italy/>/>: Design, Synthesis and immunological characterization of new glycopeptides mimetics of myelin autoantigens for the study of the molecular mechanisms of multiple sclerosis and for the development of novel diagnostic tools.

Referee of international journals: Bioorganic and Medicinal Chemistry, Bioorganic and Medicinal Chemistry Letters, Journal of Medicinal Chemistry, Chem. Med. Chem.

Scientific and Health Societies :

Since 1987: member of Italian Chemical Society (SCI) divisions of Pharmaceutical and Organic Chemistry. Since 2005: member of Alzheimer Association (not for profit association).

Field of interest:

Pharmaceutical chemistry of compounds bearing pyrazole nucleus, synthetic strategies to obtain nitrogen policondensed compounds as CBR and PBR or TSPO ligands. Synthesis of diagnostic tools for diagnosis and evaluation of Alzheimer disease and neurodegenerative pathologies. Synthesis of heterocyclic compounds for studying and imaging of cancer and neurodegenerative diseases.

Silvia SELLERI

Pubblicazioni

Legenda

Contributo su rivista |

Articolo su libro |

Libro |

Contributo in atti di convegno (proceeding) |

Brevetto |

Curatela | Altro

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Tesi di Dottorato

Elena Andreucci , Alessio Biagioni , Sara Peri , Nunzia Di Menna , Michela Pinto , Serena Martinelli , Laura Papucci , Lucia Magnelli , Gioele Renzi , Silvia Selleri , Andrea Angeli , Clemente Capasso , Fabrizio Carta , Claudiu T Supuran (2026). Ketoconazole-carbonic anhydrase inhibitors as potential anticancer agents. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 304, pp. 0-0, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Parkkinen, Jenny; Akgul, Özlem; Berrino, Emanuela; Carta, Fabrizio; Selleri, Silvia; Hammarén, Milka; Aspatwar, Ashok; Bartolucci, Gianluca; Capasso, Clemente; Parikka, Mataleena; Parkkila, Seppo; Supuran, Claudiu T. (2026). First-in-class nonsteroidal anti-inflammatory drug and carbonic anhydrase inhibitor hybrid compounds as effective antimycobacterial agents. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 316, pp. 0-0, ISSN:0223-5234 DOI

Ammara, Andrea; Carone, Alessandra; Lucarini, Laura; Sgambellone, Silvia; Marri, Silvia; Villano, Serafina; Matucci, Rosanna; Luga, Gerta; Fittipaldi, Chiara; Pecori, Riccardo; Pieraccini, Giuseppe; Di Serio, Claudia; García-Llorca, Andrea; Eysteinsson, Thor; Kalinin, Stanislav; Viita, Julius Aleksi Olavi; Urtti, Arto; Carta, Fabrizio; Selleri, Silvia; Supuran, Claudiu T (2025). Repurposing Drug Metabolites into Dual β-Adrenergic Receptor-Carbonic Anhydrase Modulators as Potential Tools for Ocular Disorders. JOURNAL OF MEDICINAL CHEMISTRY, pp. 0-0, ISSN:1520-4804 DOI

Gioele Renzi; Andrea Angeli; Silvia Selleri; Costanza Spadini; Nicolo' Mezzasalma; Marcus T. Hull; Steven L. Kelly; Clemente Capasso; Clotilde S. Cabassi; Fabrizio Carta; Claudiu T. Supuran (2025). Design and Synthesis of Ketoconazole Derivatives as Innovative Anti‐Infective Agents. ARCHIV DER PHARMAZIE, vol. 358, pp. 0-0, ISSN:1521-4184 DOI

Crocetti, Letizia; Pearce, Abigail; Vege, Venkat S.; Xu, Qi; Xu, Jing; Buthmann, Hannes; Giovannoni, Maria Paola; Guerrini, Gabriella; Catarzi, Francesca; Selleri, Silvia; Huang, Xianglin; Chandran, Aneesh; Ladds, Graham; Cilibrizzi, Agostino (2025). New heterocyclic A1/A3 adenosine receptor ligands through molecular simplification strategies. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY REPORTS, vol. 13, pp. 0-0, ISSN:2772-4174 DOI

Selleri S.; Angeli A. (2025). Malassezia spp. carbonic anhydrases. THE ENZYMES, vol. 57, pp. 65-89, ISSN:1874-6047 DOI

Chiara Baroni; Murat Bozdag; Gioele Renzi; Viviana De Luca; Clemente Capasso; Carla Bazzicalupi; Silvia Selleri; Marta Ferraroni; Fabrizio Carta; Claudiu T. Supuran (2025). X-ray crystallographic and kinetic studies of biguanide containing aryl sulfonamides as carbonic anhydrase inhibitors. RSC MEDICINAL CHEMISTRY, pp. 0-0, ISSN:2632-8682 DOI

Spadini, Costanza; Mezzasalma, Nicolo; Odigie, Amienwanlen Eugene; Angeli, Andrea; Carta, Fabrizio; Selleri, Silvia; Gandolfo, Emanuele; Taddei, Simone; Franceschi, Valentina; Minesso, Sergio; Supuran, Claudiu T.; Cabassi, Clotilde Silvia (2025). Comparative efficacy of selenoureido carbonic anhydrase inhibitors and azole antifungal drugs against clinical isolates of Malassezia pachydermatis. VETERINARY DERMATOLOGY (ONLINE), pp. 0-0, ISSN:1365-3164 DOI

Ricci A.; Zara S.; Carta F.; Di Valerio V.; Sancilio S.; Cataldi A.; Selleri S.; Supuran C.T.; Carradori S.; Gallorini M. (2024). 2-Substituted-4,7-dihydro-4-ethylpyrazolo[1,5-a]pyrimidin-7-ones alleviate LPS-induced inflammation by modulating cell metabolism via CD73 upon macrophage polarization. MOLECULAR IMMUNOLOGY, vol. 170, pp. 99-109, ISSN:0161-5890 DOI

Fabrizio Carta; Andrea Angeli; Claudiu T Supuran; Silvia Selleri (2023). CARBAMOSELENOYL DERIVATIVES AS ANTI-INFECTIVE AGENTS. Numero: WO2023/073634 A1 Fabrizio Carta; Andrea Angeli; Silvia Selleri; Claudiu T Supuran; Silvia Clotilde Cabassi; Costanza Spadini

Andrea Angeli; Marta Ferraroni; Carlotta Granchi; Filippo Minutolo; Xiaozhuo Chen; Pratik Shriwas; Emilio Russo; Antonio Leo; Silvia Selleri; Fabrizio Carta; Claudiu T. Supuran (2023). First-in-Class Dual Targeting Compounds for the Management of Seizures in Glucose Transporter Type 1 Deficiency Syndrome. JOURNAL OF MEDICINAL CHEMISTRY, pp. 0-0, ISSN:0022-2623 DOI

Baroni Chiara, Ferraroni Marta, Carta Fabrizio, Selleri Silvia, Capasso Clemente, De Luca Viviana, Supuran Claudiu T. (2023). Structural characterization of carbonic anhydrase complexes with dual-target inhibitors.. In: 12th International Conference on Carbonic Anhydrases, 12th International Conference on Carbonic Anhydrases, pp. 57-57.

Baroni Chiara, Ferraroni Marta, Carta Fabrizio, Selleri Silvia, Capasso Clemente, De Luca Viviana, Supuran Claudiu T. (2023). Structural characterization of carbonic anhydrase complexes with anticancer inhibitors. In: 8th International Doctoral School on Biological Crystallization, 8th International Doctoral School on Biological Crystallization, pp. 112-112.

Angeli A.; Velluzzi A.; Selleri S.; Capasso C.; Spadini C.; Iannarelli M.; Cabassi C.S.; Carta F.; Supuran C.T. (2022). Seleno Containing Compounds as Potent and Selective Antifungal Agents. ACS INFECTIOUS DISEASES, vol. 8, pp. 1905-1919, ISSN:2373-8227 DOI

Bozdag M.; Cravey L.; Combs J.; Kota A.; McKenna R.; Angeli A.; Selleri S.; Carta F.; Supuran C.T. (2022). Small Molecule Alkoxy Oriented Selectiveness on Human Carbonic Anhydrase II and IX Inhibition. CHEMMEDCHEM, vol. 17, pp. 0-0, ISSN:1860-7179 DOI

De Luca V.; Angeli A.; Mazzone V.; Adelfio C.; Carginale V.; Scaloni A.; Carta F.; Selleri S.; Supuran C.T.; Capasso C. (2022). Heterologous expression and biochemical characterisation of the recombinant β-carbonic anhydrase (MpaCA) from the warm-blooded vertebrate pathogen malassezia pachydermatis. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 62-68, ISSN:1475-6366 DOI

Gumus A.; Bozdag M.; Akdemir A.; Angeli A.; Selleri S.; Carta F.; Supuran C.T. (2022). Thiosemicarbazide-Substituted Coumarins as Selective Inhibitors of the Tumor Associated Human Carbonic Anhydrases IX and XII. MOLECULES, vol. 27, pp. 0-0, ISSN:1420-3049 DOI

Angeli A.; Pinteala M.; Maier S.S.; Toti A.; Di Cesare Mannelli L.; Ghelardini C.; Selleri S.; Carta F.; Supuran C.T. (2021). Tellurides bearing benzensulfonamide as carbonic anhydrase inhibitors with potent antitumor activity. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 45, pp. 0-0, ISSN:0960-894X DOI

Akgul O.; Angeli A.; Selleri S.; Capasso C.; Supuran C.T.; Carta F. (2021). Taurultams incorporating arylsulfonamide: First in vitro inhibition studies of α-, β- and γ-class Carbonic Anhydrases from Vibrio cholerae and Burkholderia pseudomallei. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 219, pp. 0-0, ISSN:0223-5234 DOI

Akgul O.; Singh S.; Andring J.T.; McKenna R.; Selleri S.; Carta F.; Angeli A.; Supuran C.T. (2021). Handling drug-target selectivity: A study on ureido containing Carbonic Anhydrase inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, pp. 0-0, ISSN:0223-5234 DOI

Gumus A.; Bozdag M.; Angeli A.; Peat T.S.; Carta F.; Supuran C.T.; Selleri S. (2021). Privileged scaffolds in medicinal chemistry: Studies on pyrazolo[1,5-a]pyrimidines on sulfonamide containing Carbonic Anhydrase inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 49, pp. 0-0, ISSN:0960-894X DOI

Andrea Angeli; Marta Ferraroni; Akram A. Da’dara; Silvia Selleri; Mariana Pinteala; Fabrizio Carta; Patrick J. Skelly; Claudiu T. Supuran (2021). Structural Insights into Schistosoma mansoni Carbonic Anhydrase (SmCA) Inhibition by Selenoureido-Substituted Benzenesulfonamides. JOURNAL OF MEDICINAL CHEMISTRY, pp. 0-0, ISSN:0022-2623 DOI

De Luca V.; Angeli A.; Mazzone V.; Adelfio C.; Carta F.; Selleri S.; Carginale V.; Scaloni A.; Supuran C.T.; Capasso C. (2021). Inhibitory effects of sulfonamide derivatives on the β‐carbonic anhydrase (Mpaca) from malassezia pachydermatis, a commensal, pathogenic fungus present in domestic animals. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, pp. 0-0, ISSN:1422-0067 DOI

Angeli A.; Peat T.S.; Selleri S.; Saleh Alfawaz Altamimi A.; Supuran C.T.; Carta F. (2020). X-ray crystallography of Epacadostat in adduct with Carbonic Anhydrase IX. BIOORGANIC CHEMISTRY, vol. 97, pp. 103669-103669, ISSN:0045-2068 DOI

Berrino E.; Angeli A.; Zhdanov D.D.; Kiryukhina A.P.; Milaneschi A.; De Luca A.; Bozdag M.; Carradori S.; Selleri S.; Bartolucci G.; Peat T.S.; Ferraroni M.; Supuran C.T.; Carta F. (2020). Azidothymidine "clicked" into 1,2,3-Triazoles: First Report on Carbonic Anhydrase-Telomerase Dual-Hybrid Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, pp. 7392-7409, ISSN:0022-2623 DOI

Bua S.; Lucarini L.; Micheli L.; Menicatti M.; Bartolucci G.; Selleri S.; Di Cesare Mannelli L.; Ghelardini C.; Masini E.; Carta F.; Gratteri P.; Nocentini A.; Supuran C.T. (2020). Bioisosteric Development of Multitarget Nonsteroidal Anti-Inflammatory Drug-Carbonic Anhydrases Inhibitor Hybrids for the Management of Rheumatoid Arthritis. JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, pp. 2325-2342, ISSN:0022-2623 DOI Accesso ONLINE all'editore

Bonardi, Alessandro; Vermelho, Alane Beatriz; Da Silva Cardoso, Veronica; De Souza Pereira, Mirian Claudia; Da Silva Lara, Leonardo; Selleri, Silvia; Gratteri, Paola; Supuran, Claudiu T.; Nocentini, Alessio (2019). N-Nitrosulfonamides as Carbonic Anhydrase Inhibitors: A Promising Chemotype for Targeting Chagas Disease and Leishmaniasis. ACS MEDICINAL CHEMISTRY LETTERS, vol. 10, pp. 413-418, ISSN:1948-5875 DOI Accesso ONLINE all'editore

C. Sestini, S. Orlandini, S. Furlanetto, E. Ottomani, S. Selleri, L. Marzullo, M. Del Bubba, P. Gratteri (2019). Development of a new home-care detergent: experimental design in the optimization of performances and study on the safety of use through physico-chemical and toxicological data. In: XXVIII Congress of the Analytical Chemistry Division, Bari, 22-26 Settembre 2019, Società Chimica Italiana, pp. 1-2, ISBN:9788894952100

Eysteinsson T.; Gudmundsdottir H.; Hardarson A.O.; Berrino E.; Selleri S.; Supuran C.T.; Carta F. (2019). Carbonic anhydrase inhibitors of different structures dilate pre-contracted porcine retinal arteries. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 20, pp. 467-479, ISSN:1661-6596 DOI Accesso ONLINE all'editore

Bozdag M.; Poli G.; Angeli A.; Lucarini E.; Tuccinardi T.; Di Cesare Mannelli L.; Selleri S.; Ghelardini C.; Winum J.-Y.; Carta F.; Supuran C.T. (2019). N-aryl-N’-ureido-O-sulfamates: Potent and selective inhibitors of the human Carbonic Anhydrase VII isoform with neuropathic pain relieving properties. BIOORGANIC CHEMISTRY, vol. 89, pp. 103033-103043, ISSN:0045-2068 DOI Accesso ONLINE all'editore

Angeli A.; Ferraroni M.; Nocentini A.; Selleri S.; Gratteri P.; Supuran C.T.; Carta F. (2019). Polypharmacology of epacadostat: A potent and selective inhibitor of the tumor associated carbonic anhydrases IX and XII. CHEMICAL COMMUNICATIONS, vol. 55, pp. 5720-5723, ISSN:1359-7345 DOI Accesso ONLINE all'editore

Al-Tamimi A.-M.S.; Etxebeste-Mitxeltorena M.; Sanmartin C.; Jimenez-Ruiz A.; Syrjanen L.; Parkkila S.; Selleri S.; Carta F.; Angeli A.; Supuran C.T. (2019). Discovery of new organoselenium compounds as antileishmanial agents. BIOORGANIC CHEMISTRY, vol. 86, pp. 339-345, ISSN:0045-2068 DOI Accesso ONLINE all'editore

Pasha A.; Vignoli M.; Subbiani A.; Nocentini A.; Selleri S.; Gratteri P.; Dabraio A.; Casini T.; Filippi L.; Fotzi I.; Favre C.; Calvani M. (2019). β3-adrenoreceptor activity limits apigenin efficacy in ewing sarcoma cells: A dual approach to prevent cell survival. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 20, pp. 2149-2162, ISSN:1422-0067 DOI Accesso ONLINE all'editore

Nocentini, Alessio; Ceruso, Mariangela; Bua, Silvia; Lomelino, Carrie L.; Andring, Jacob T.; McKenna, Robert; Lanzi, Cecilia; Sgambellone, Silvia; Pecori, Riccardo; Matucci, Rosanna; Filippi, Luca; Gratteri, Paola; Carta, Fabrizio; Masini, Emanuela; Selleri, Silvia*; Supuran, Claudiu T. (2018). Discovery of β-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy. JOURNAL OF MEDICINAL CHEMISTRY, vol. 61, pp. 5380-5394, ISSN:0022-2623 DOI Accesso ONLINE all'editore

Nocentini, Alessio; Carta, Fabrizio; Tanc, Muhammet; Selleri, Silvia; Supuran, Claudiu T.; Bazzicalupi, Carla*; Gratteri, Paola (2018). Deciphering the Mechanism of Human Carbonic Anhydrases Inhibition with Sulfocoumarins: Computational and Experimental Studies. CHEMISTRY-A EUROPEAN JOURNAL, vol. 24, pp. 7840-7844, ISSN:0947-6539 DOI Accesso ONLINE all'editore

Selleri, S. (2018). Remarkable Enhancement in Boron Uptake Within Glioblastoma Cells With Carboranyl-Indole Carboxamides. CHEMISTRY - AN ASIAN JOURNAL, vol. 13, pp. 3321-3327, ISSN:1861-471X DOI

Gabriella Guerrini, Giovanna Ciciani, Simona Daniele, Claudia Martini, Camilla Costagli, Chiara Guarino, Silvia Selleri (2018). A new class of pyrazolo[5,1-c][1,2,4]triazines as γ-aminobutyric type A (GABAA) receptor subtype ligand: synthesis and pharmacological evaluation. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 26, pp. 2475-2487, ISSN:0968-0896 DOI

Selleri Silvia (2017). A cent’anni dalla scomparsa di Ugo Schiff Un protagonista del sogno di Bettino Ricasoli per Firenze, “Atene d’Italia”. In: A cent’anni dalla scomparsa di Ugo Schiff, Firenze, Dicembre 2016, Regione Toscana, vol. Edizioni dell'Assemblea 138, pp. 81-99, ISBN:9788889365-81-6 Accesso ONLINE all'editore

Gabriella, Guerrini; Ciciani, Giovanna; Daniele, Simona; lorenzo di cesare mannelli, ; Ghelardini, Carla; Martini, Claudia; Silvia, Selleri (2017). Synthesis and pharmacological evaluation of pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives as potential GABAA-R ligands. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 25, pp. 1901-1906, ISSN:0968-0896 DOI

Selleri; Silvia (2017). A cent’anni dalla scomparsa di Ugo Schiff Un protagonista del sogno di Bettino Ricasoli per Firenze, “Atene d’Italia”. In: Atti del Convegno per il centenario della morte del grande chimico Ugo Schiff (1915-2015), firenze, assemblea regionale della toscana, vol. Edizioni dell'Assemblea 138, pp. 81-99.

Dott.ssa Cecilia Bartoli; Prof.ssa Silvia Selleri (2015). SYNTHETIC PATHWAYS OF TSPO LIGANDS AS THERANOSTIC TOOLS. (Tutor: Prof.ssa Silvia Selleri)

Banister, Samuel D.; Beinat, Corinne; Wilkinson, Shane M.; Shen, Bin; Bartoli, Cecilia; Selleri, Silvia; Da Pozzo, Eleonora; Martini, Claudia; Chin, Frederick T.; Kassiou, Michael (2015). Ether analogues of DPA-714 with subnanomolar affinity for the translocator protein (TSPO). EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 93, pp. 392-400, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Fontani, Marco; Orna, Mary Virginia; Selleri, Silvia; Bartoli, Cecilia (2015). A feminine task: Karlik's and Bernert's discovery of the last natural occurring element. CHIMICA OGGI-CHEMISTRY TODAY, vol. 33, pp. 67-70, ISSN:0392-839X Accesso ONLINE all'editore

AM Scarf; C Luus; E Da Pozzo; S Selleri; C Guarino; C Martini; LM Ittner; M Kassiou. (2012). Evidence for complex binding profiles and species differences at the translocator protein (TSPO) (18 kDa).. CURRENT MOLECULAR MEDICINE, vol. 12, pp. 488-493, ISSN:1566-5240 Accesso ONLINE all'editore

G. Guerrini; G. Ciciani; F. Bruni; S. Selleri; C. Martini; S. Daniele; C. Ghelardini; L. Di Cesare Mannelli; A. Costanzo (2011). Development of ligands at gamma aminobutyrric acid type A (GABAA) receptor subtype as new agent for pain relief.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, pp. 7441-7452, ISSN:1464-3391 DOI

G. Guerrini; G. Ciciani; F. Bruni; S. Selleri; F. Melani; S. Daniele; C. Martini; A. Costanzo (2011). New 3-, 8-disubstituted pyrazolo[5,1-c][1,2,4]benzotriazines useful for studying the interaction with the HBp-3 area (hydrogen bond point area) in the benzodiazepine site on the gamma-aminobutyric acid type A (GABAA) receptor. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, pp. 3074-3085, ISSN:1464-3391 DOI

A. Damont; R. Boisgard; B. Kuhnast; F. Lemée; G. Raggiri; A.M. Scarf; E. Da Pozzo; S. Selleri; C. Martini; B. Tavitian; M. Kassiou; F. Dollé (2011). Synthesis of 6-[18 F]fluoro-PBR28, a novel radiotracer for imaging the TSPO 18 kDa with PET. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 21, pp. 4819-4822, ISSN:1464-3405 DOI

A. Reynolds; R. Hanani; D. Hibbs; A. Damont; E. Da Pozzo; S. Selleri; F. Dollé; C. Martini; M Kassiou (2010). Pyrazolo[1,5-a]pyrimidine acetamides: 4-phenyl alkyl ether derivatives as potent ligands for the 18 KDa translocator protein (TSPO). BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 20, pp. 5799-5802, ISSN:0960-894X DOI

BRUNI, F.; SELLERI, S.; COSTANZO, A.; GUERRINI, G.; CASILLI, M. L. (2010). ChemInform Abstract: Reactivity of 7‐(2‐Dimethylaminovinyl)pyrazolo(1,5‐a)pyrimidines: Synthesis of Pyrazolo(1,5‐a)pyrido(3,4‐e)pyrimidine Derivatives as Potential Benzodiazepine Receptor Ligands. Part 1. CHEM INFORM, vol. 26, pp. 1-1, ISSN:0931-7597 DOI

G. Guerrini; G. Ciciani; F. Bruni; S. Selleri; C. Guarino; F. Melani; M. Montali; S. Daniele; C. Martini; C. Ghelardini; M. Norcini; S. Ciattini; A. Costanzo (2010). New fluoro derivatives of the pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide system: evaluation of fluorine binding properties in the benzodiazepine site on gamma-aminobutyrric acid type A (GABAA) receptor. Design, synthesis, biological evaluation, and molecular modeling investigation.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, pp. 7532-7548, ISSN:1520-4804 DOI

BRUNI, F.; SELLERI, S.; COSTANZO, A.; GUERRINI, G.; CASILLI, M. L.; SACCO, C.; DONATO, R. (2010). ChemInform Abstract: Pyrazolo(1,5‐a)pyrido(3,4‐e)pyrimidin‐6‐ones. Part 1. Synthesis and in vitro Antimicrobial Evaluation. CHEM INFORM, vol. 27, pp. 1-1, ISSN:0931-7597 DOI

C.Bonaccini; C.Guarino; M.Chioccioli; S.Selleri; P.Gratteri (2009). Homology modeling, docking and MM-GBSA rescoring of benzodiazepine receptor ligands: structural features regulating alpha1-versus alpha5- subtype selectivity. In: Frontiers in Medicinal Chemistry: emerging targets, novel candidates and innovative strategies, Barcelona, Spain, October 4-6, 2009, vol. 34, pp. 175-175.

G. Guerrini; G. Ciciani; G. Cambi; F. Bruni; S.Selleri; C. Guarino; F. Melani; M. Montali; C: Martini; C. Ghelardini; M. Norcini; A. Costanzo (2009). Synthesis, in vivo evaluation, and molecular modeling studies of new pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide derivatives. Identification of a bifunctional hydrogen bond area related to the inverse-agonism. JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, pp. 4668-4682, ISSN:0022-2623 DOI

S. Chimichi; M. Boccalini; S. Selleri; C. Costagli; G. Guerrini; G. Viola (2008). On the reactivity of 6-acetyl-7-(2-dimethylaminovinyl)pyrazolo[1,5-a]pyrimidines with 1,3- and 1,4-bisnucleophiles. ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 6, pp. 739-744, ISSN:1477-0520 DOI

G. Guerrini; G. Ciciani; G. Cambi; F. Bruni; S. Selleri; F. Melani; M. Montali; C. Martini; C. Ghelardini; M. Norcini; A. Costanzo (2008). Novel 3-aroylpyrazolo[5,1-c][1,2,4] benzotriazines 5-oxides 8-substituted, ligands at GABAA/benzodiazepine receptor complex: synthesis, pharmacological and molecular modelling studies.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, pp. 4471-4489, ISSN:1464-3391 DOI

M.L. James; R.R. Fulton; J. Vercoullie; D.J. Henderson; L. Garreauu; S. Chalon; F. Dollè; S. Selleri; D. Guilloteau; M. Kassiou (2008). DPA-714 a new Translocator Protei-Specific Ligand: Synthesis, Radiofluorination and Pharmacological Charachterization. THE JOURNAL OF NUCLEAR MEDICINE, vol. 49, pp. 814-822, ISSN:0161-5505

G. Ciciani; M. Coronnello; G. Guerrini; S.Selleri; M.Cantore; P. Failli; E. Mini; A. Costanzo (2008). Synthesis of new pyrazolo[5,1-c][1,2,4]benzotriazines, pyrazolo[5,1-c]pyrido[4,3-e][1,2,4]triazines and their open analogues as cytotoxic agents in normoxic and hypoxic conditions.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, pp. 9409-9419, ISSN:1464-3391 DOI

G. GUERRINI; G. CICIANI; G. CAMBI; F. BRUNI; S. SELLERI; F. BESNARD; M. MONTALI; C. MARTINI; C. GHELARDINI; N. GALEOTTI; A. COSTANZO (2007). Novel 3-iodo-8-ethoxypyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide as promising lead for design of alpha5-inverse agonist, useful tools for therapy of mnemonic damage.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 15, pp. 2573-2586, ISSN:0968-0896 DOI Accesso ONLINE all'editore

JAMES M.L; S. SELLERI; KASSIOU M (2006). Development of ligands for peripheral benzodiazepine receptor. CURRENT MEDICINAL CHEMISTRY, vol. 13, pp. 1991-2001, ISSN:1875-533X DOI

C. THOMINIAUX; F. DOLLE; ML JAMES; Y BRAMOULLE; H. BOUTIN; L. BESRET; M.C. GREGOIRE; H. VALETTE; M. BOTTLANDER; B. TAVITIAN; PH HANTRAYE; S. SELLERI; M. KASSIOU (2006). Improved Synthesis of the Peripheral Benzodiazepine Receptor Ligand [11C] DPA-713 using [11C]methyl triflate.. APPLIED RADIATION AND ISOTOPES, vol. 64, pp. 570-573, ISSN:0969-8043

G. GUERRINI; A. COSTANZO; G. CICIANI; F. BRUNI; S. SELLERI; C. COSTAGLI; B. COSTA; C. MARTINI; G. DE SIENA; P. MALMBERG; F. BESNARD (2006). Benzodiazepine receptor ligands. 8. Synthesis and pharamcological evaluation of new pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide 3- and 8-disubstituted: high affinity ligands endowed with inverse-agonist pharmacological efficacy.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 14, pp. 758-775, ISSN:0968-0896 Accesso ONLINE all'editore

S. SELLERI; P. GRATTERI; C. COSTAGLI; C. BONACCINI; A. COSTANZO; F. MELANI; G. GUERRINI; G. CICIANI; B. COSTA; C. MARTINI; F. BRUNI; F. SPINETTI (2005). Insight into 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl acetamides as Peripheral Benzodiazepine Receptor Ligands: synthesis, biological evaluation and 3D-QSAR investigation.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 13, pp. 4821-4834, ISSN:0968-0896 DOI Accesso ONLINE all'editore

M. CORONNELLO; G. CICIANI; E. MINI; G. GUERRINI; B. CACIAGLI; S. SELLERI; A. COSTANZO; T. MAZZEI (2005). Cytotoxic activity of 3-nitropyrazolo[5,1-c][1,2,4]benzotriazine derivatives: a new series of anti-proliferative agents.. ANTI-CANCER DRUGS, vol. 16, pp. 645-651, ISSN:0959-4973 DOI

S. SELLERI; F. BRUNI; C. COSTAGLI; A. COSTANZO; G. GUERRINI; G. CICIANI; P. GRATTERI; F. BESNARD; B. COSTA; C. MARTINI; G. DE SIENA; P. MALMBERG; M. MONTALI; J. FOHLIN (2005). A novel selective GABA-A alpha1 receptor agonist displaying sedative and anxiolytic-like properties in rodents.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, pp. 6756-6760, ISSN:0022-2623 DOI Accesso ONLINE all'editore

S. SELLERI; F. BRUNI; C. COSTAGLI; A. COSTANZO; G. GUERRINI; G. CICIANI; P.GRATTERI; C.BONACCINI; P.MALMBERG AIELLO; F.BESNARD; S.RENARD; B. COSTA; C. MARTINI (2003). Synthesis and Benzodiazepine Receptor Affinity of Pyrazolo [1,5-a]pyrimidine Derivatives.3. New 6-(3-Thienyl) Series as a1 Selective Ligands. JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, pp. 310-313, ISSN:0022-2623 DOI Accesso ONLINE all'editore

F. BRUNI; P. MALMBERG; A. COSTANZO; G. CICIANI; G. GUERRINI; S. SELLERI; C. COSTAGLI; C. MARTINI; B. COSTA; F. BESNARD (2002). BENZODIAZEPINE RECEPTOR LIGANDS. 7. SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF NEW 3-ESTERS OF THE 8-CHLOROPYRAZOLO[5,1-C][1,2,4]BENZOTRIAZINE 5-OXIDE. 3-(2- THIENYLMETHOXYCARBONYL) DERIVATIVE: AN ANXIOSELECTIVE AGENT IN RODENTS.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 45, pp. 5710-5720, ISSN:0022-2623 DOI

A. COSTANZO; G. GUERRINI; G. CICIANI; F. BRUNI; C. COSTAGLI; S. SELLERI; B. COSTA; C. MARTINI; P. MALMBERG AIELLO (2002). Synthesis and pharmacological evaluation of 3-(2-furyl)- and 3-(3-furyl)-(-chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides, new 3-heteroaryl substituted benzodiazepine receptor ligands.. MEDICINAL CHEMISTRY RESEARCH, vol. 11, pp. 87-101, ISSN:1054-2523

S. SELLERI; F. BRUNI; C. COSTAGLI; A. COSTANZO; G. GUERRINI; G. CICIANI; B. COSTA; C. MARTINI (2001). 2-Arylpyrazolo[1,5-a]pyrimidin-3-yl acetamides. New potent and selective Peripheral Benzodiazepine Receptor ligands. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 9, pp. 2661-2671, ISSN:0968-0896

A. COSTANZO; G. GUERRINI; G. CICIANI; F. BRUNI; C. COSTAGLI; S. SELLERI; B. COSTA; C. MARTINI; P. MALMBERG AIELLO (2001). Benzodiazepine receptor ligands. 6. New 3-(2-,3- or 4-substituted benzyloxycarbonyl) derivatives of 8-chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide receptor affinity and In vivo testing C. Martini, P. Malmberg Aiello. MEDICINAL CHEMISTRY RESEARCH, vol. 10, pp. 366-377, ISSN:1054-2523

S. SELLERI; F. BRUNI; C. COSTAGLI; A. COSTANZO; G. GUERRINI; G. CICIANI; P. MALBERG; C. LAMBERTI; B. COSTA; C. MARTINI (2000). Synthesis and BZR affinity of pyrazolo [ 1,5-a ] pyrimidine derivatives. Part 2:Further Investigation on the 3-aryl substituents.. MEDICINAL CHEMISTRY RESEARCH, vol. 10, pp. 92-113, ISSN:1054-2523

Costanzo A.; Ciciani G.; Guerrini G.; Bruni F.; Selleri S.; Donato R.; Sacco C.; Musiu C.; Milia C.; Longu S.; Minnei C.; La Colla P. (1999). Antiproliferative and antimicrobial activities of pyrazolo[5,1- c][1,2,4]benzotriazine 5-oxides and their 5-deoxyderivatives. MEDICINAL CHEMISTRY RESEARCH, vol. 9, pp. 223-238, ISSN:1054-2523

S. SELLERI; F. BRUNI; C. COSTAGLI; A. COSTANZO; G. GUERRINI; G. CICIANI; B. COSTA; C. MARTINI (1999). Synthesis, Benzodiazepine receptor affinity of pyrazolo[1,5-a]pyrimidine derivatives. Study of the structural features for BZR recognition- Part I.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 7, pp. 2705-2711, ISSN:0968-0896

A. COSTANZO; G. GUERRINI; G. CICIANI; F. BRUNI; S. SELLERI; B. COSTA; C. MARTINI; P. MALMBERG; A. IPPONI; A. LUCACCHINI (1999). BENZODIAZEPINE RECEPTOR (BZR) LIGANDS.5. NEW 3-ALKYLOXYCARBONYL-, 3-CYCLOALKYLOXYCARBONYL-,3-ARYLOXYCARBONYLDERIVATIVES OF PYRAZOLO [5,1-C][1,2,4]BENZOTRIAZINE 5-OXIDES: A STUDY ON THE 3-ESTER FUNCTION MODIFICATION. MEDICINAL CHEMISTRY RESEARCH, vol. 9, pp. 322-339, ISSN:1054-2523

Guerrini G.; Costanzo A.; Bruni F.; Ciciani G.; Selleri S.; Gratteri P.; Costa B.; Martini C.; Lucacchini A. (1999). Benzodiazepine receptor ligands III. Synthesis and biological evaluation of 2- and/or 3-substituted pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides. IL FARMACO, vol. 54, pp. 375-389, ISSN:0014-827X DOI

G. GUERRINI; A. COSTANZO; F. BRUNI; G. CICIANI; S. SELLERI; P. GRATTERI; B. COSTA; C. MARTINI; A. LUCACCHINI (1999). Benzodiazepine receptor ligands. Part III. Synthesis and biological evaluation of 2 and/or 3-substituted pyrazolo[5,1-c][1,2,4] benzotriazine 5-oxides.. IL FARMACO, vol. 54, pp. 375-389, ISSN:0014-827X

A. COSTANZO; G. GUERRINI; G. CICIANI; F. BRUNI; S. SELLERI; B. COSTA; C. MARTINI; A. LUCACCHINI; P. MALMBERG AIELLO; A. IPPONI (1999). Benzodiazepine receptor ligands. 4.Synthesis, and pharmacological evaluation of 3-hetroaryl-8-chloro pyrazolo[5,1-c][1,2,4] benzotriazine 5-oxides.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, pp. 2218-2226, ISSN:0022-2623

F. BRUNI; S. SELLERI; A. COSTANZO; G. GUERRINI; G. CICIANI; P. LA COLLA; R. DONATO; C. SACCO; C. MUSIU; C. MILIA; S. LONGU; C. MINNEI (1999). Antiproliferative and antimicrobial activities of pyrazolo[5,1-c][1,2,4]benzotriazines 5-oxides and their 5-deoxyderivatives.. MEDICINAL CHEMISTRY RESEARCH, vol. 9, pp. 223-238, ISSN:1054-2523

Costanzo A.; Guerrini G.; Ciciani G.; Bruni F.; Selleri S.; Costa B.; Martini C.; Lucacchini A.; Malmberg Aiello P.; Ipponi A. (1999). Benzodiazepine receptor ligands. 4. Synthesis and pharmacological evaluation of 3-heteroaryl-8-chloropyrazolo[5,1-c][1,2,4]benzotriazine 5- oxides. JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, pp. 2218-2226, ISSN:1520-4804 DOI

Selleri S.; Bruni F.; Costagli C.; Costanzo A.; Guerrini G.; Ciciani G.; Costa B.; Martini C. (1999). Synthesis and BZR affinity of pyrazolo[1,5-a]pyrimidine derivatives. Part 1: Study of the structural features for BZR recognition. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 7, pp. 2705-2711, ISSN:0968-0896 DOI

F. BRUNI; A. COSTANZO; G. CICIANI; G. GUERRINI; S. SELLERI; C. MARTINI; A. LUCACCHINI; B. COSTA; S. CAPPELLETTI (1998). BENZODIAZEPINE RECEPTOR LIGANDS. PART II. SYNTHESIS AND BIOLOGICAL EVALUATION OF PYRAZOLO[5,1-C][1,2,4]BENZOTRIAZINES 4-OXIDE.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, pp. 237-244, ISSN:0223-5234

Costanzo A.; Guerrini G.; Bruni F.; Ciciani G.; Selleri S.; Cappelletti S.; Costa B.; Martini C.; Lucacchini A. (1998). Benzodiazepine receptor ligands - Part II. Synthesis and biological evaluation of pyrazolo[5,1-c][1,2,4]benzotriazine 4-oxide. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, pp. 237-244, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Bruni F.; Selleri S.; Costanzo A.; Guerrini G.; Ciciani G.; Costagli C.; Sacco C.; Donato R. (1997). Pyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-6-ones. II. Synthesis and in vitro antimicrobial evaluation. IL FARMACO, vol. 52, pp. 639-643, ISSN:0014-827X

S. SELLERI; F. BRUNI; A. COSTANZO; G. GUERRINI; M. CASILLI; L. GIUSTI; A. LUCACCHINI; C. MARTINI; P. MALMBERG; C. LAMBERTI (1997). SYNTHESIS, BENZODIAZEPINE RECEPTOR AFFINITY AND ANTICONVULSANT ACTIVITY OF 3-ARYL-4,7-DIHYDRO-6-(N1'-ALKYLPYRAZOL-3' OR 5'-YL)PYRAZOLO[1,5-A]PYRIMIDIN-7-ONES. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 32, pp. 941-953, ISSN:0223-5234

F. BRUNI; S. SELLERI; A. COSTANZO; G. GUERRINI; G. CICIANI; C. COSTAGLI; C. SACCO; R. DONATO (1997). PYRAZOLO[1,5-A]PYRIDO[3,4-E]PYRIMIDN-6-ONES. II. SYNTHESIS AND IN VITRO ANTIMICROBIAL EVALUATION.. IL FARMACO, vol. 52, pp. 639-643, ISSN:0014-827X

F. BRUNI; S. SELLERI; A. COSTANZO; G. GUERRINI; M. CASILLI; C. SACCO; R. DONATO (1996). PYRAZOLO[1,5-A]PYRIDO[3,4-E]PYRIMIDIN-6-ONES. I. SYNTHESIS AND IN VITRO ANTIMICROBIAL AND ANTIFUNGAL EVALUATION.. IL FARMACO, vol. 51, pp. 451-455, ISSN:0014-827X

CHIMICHI, S.; BRUNI, F.; COSIMELLI, B.; SELLERI, S.; VALLE, G. (1996). Chemistry of Substituted Pyrazolo[1,5-a]pyrimidines. Part 5. 7-Oxo-6-[bpyrazol-3’(5’)-yl]-4,7-dihydropyrazolo[1,5-a]pyrimidines from 6-Ethoxycarbonyl-7-(2-dimethylaminovinyl)-pyrazolo[1,5-a]pyrimidines: Elucidation of the Reaction Mechanism through NMR Spectroscopy and X-Ray Diffraction Analysis. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS II, vol. .., pp. 1147-1152, ISSN:0300-9580 DOI

S. CHIMICHI; F.BRUNI; B.COSIMELLI; S.SELLERI; G.VALLE (1996). Chemistry of Substituted Pyrazolo[1,5-a]pyrimidines. Part 5. 7-Oxo-6-[bpyrazol-3’(5’)-yl]-4,7-dihydropyrazolo[1,5-a]pyrimidines from 6-Ethoxycarbonyl-7-(2-dimethylaminovinyl)-pyrazolo[1,5-a]pyrimidines: Elucidation of the Reaction Mechanism through NMR Spectroscopy and X-Ray Diffraction Analysis. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS II, vol. .., pp. 1147-1152, ISSN:0300-9580, Royal Society of Chemistry:Thomas Graham House, Science Park, Cambridge CB4 0WF United Kingdom:011 44 1223 432360, EMAIL: sales@rsc.org, INTERNET: http://www.rsc.org, http://www.chensoc.org, Fax: 011 44 1223 423429:

G. GUERRINI; A. COSTANZO; F. BRUNI; S. SELLERI; L. GIUSTI; A. LUCACCHINI; C. MARTINI (1996). BENZODIAZEPINE RECEPTOR LIGANDS. SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF 3-, 7- AND 8-SUBSTITUTED [5,1-C][1,2,4]BENZOTRIAZINES AND 5-OXIDE DERIVATIVES. PART I.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 31, pp. 259-272, ISSN:0223-5234

Bruni F.; Selleri S.; Costanzo A.; Guerrini G.; Casilli M.L.; Sacco C.; Donato R. (1996). Pyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-6-ones. I. Synthesis and in vitro antimicrobial evaluation. IL FARMACO, vol. 51, pp. 451-455, ISSN:0014-827X

Bruni F.; Selleri S.; Costanzo A.; Guerrini G.; Casilli M.L.; Giusti L. (1995). Reactivity of 7‐(2‐dimethylaminovinyl)pyrazolo[1,5‐a]pyrimidines: Synthesis of pyrazolo[1,5‐a]pyrido[3,4‐e]pyrimidine derivatives as potential benzodiazepine receptor ligands. 2. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 32, pp. 291-298, ISSN:1943-5193 DOI

Bruni, Fabrizio, Selleri, Silvia, Costanzo, Annarella, Guerrini, Gabriella, Casilli Lucia, Giusti, Laura (1995). ChemiInform Abstract: reactivity of 7-(2-dimethylaminovinyl)pyrazolo[1,5-a]pyrimidines: synthesis of pyrazolo[1,5-a]pyrido[3,4-e]pyrimidine derivatives as potential benzodiazepine receptor ligands. Part 2. CHEM INFORM, vol. 26, pp. 1-1, ISSN:0931-7597 DOI

F. BRUNI; A. COSTANZO; G. GUERRINI; S. SELLERI; M. CASILLI; L. GIUSTI (1995). REACTIVITY OF 7-(2-DIMETHYLAMINOVINYL)PYRAZOLO[1,5-A]PYRIMIDINES: SYNTHESIS OF PYRAZOLO[1,5-A]PYRIDO[3,4-E]PYRIMIDINE DERIVATIVES AS POTENTIAL BENZODIAZEPINE RECEPTOR LIGANDS. 2.. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 32, pp. 291-298, ISSN:0022-152X

S. SELLERI; F. BRUNI; A. COSTANZO; G. GUERRINI; M. CASILLI; L. GIUSTI; A. LUCACCHINI; C. MARTINI (1995). NEW 2,3-SUBSTITUTED 4,7-DIHYDRO-6-(1'HPYRAZOL-3'-YL)PYRAZOLO[1,5-A]PYRIMIDI-7-ONES AND RELATED COMPOUNDS: SYNTHESIS AND BENZODIAZEPINE RECEPTOR BINDING STUDY.. IL FARMACO, vol. 50, pp. 679-687, ISSN:0014-827X

COSTANZO, A.; GUERRINI, G.; BRUNI, F.; SELLERI, S. (1994). REACTIVITY OF 1-(2-NITROFENIL)-5-AMINOPYRAZOLES UNDER BASIC CONDITIONS AND SYNTHESIS OF NEW 3-, 7-, AND 8-SUBSTITUTED PYRAZOLO[5,1-C][1,2,4]BENZOTRIAZINE 5-OXIDES, AS BENZODIAZEPINE RECEPTOR LIGANDS.JOURNAL OF HETEROCYCLIC CHEMISTRY , - A. COSTANZO, G. GUERRINI, F. BRUNI, S. SELLERI. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 31, pp. 1369-1376, ISSN:1943-5193

Costanzo A.; Guerrini G.; Bruni F.; Selleri S. (1994). Reactivity of 1‐(2‐nitrophenyl)‐5‐aminopyrazoles under basic conditions and synthesis of new 3‐, 7‐, and 8‐substituted pyrazolo[5,1‐c][1,2,4]benzotriazine 5‐oxides, as benzodiazepine receptor ligands. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 31, pp. 1369-1376, ISSN:1943-5193 DOI

Chimichi S.; Cosimelli B.; Bruni F.; Selleri S.; Costanzo A.; Guerrini G.; Valle G. (1994). Chemistry of substituted pyrazolo[1,5-a]pyrimidines. Part 4.1A Structural Correction of a Series of Pyrazolo[5′,1′:2,3]pyrimido[5,4-d][1,2]diazepines on the basis of NMR spectroscopy and X-ray diffraction analysis. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS II, pp. 1657-1660, ISSN:0300-9580 DOI

F. BRUNI; S. SELLERI; A. COSTANZO; G. GUERRINI; M. CASILLI (1994). REACTIVITY OF 7-(2-DIMETHYLAMINOVINYL) PYRAZOLO[1,5-A]PYRIMIDINES: SYNTHESIS OF PYRAZOLO[1,5-A]PYRIDO[3,4-E]PYRIMIDINE DERIVATIVES AS POTENTIAL BENZODIAZEPINE RECEPTOR LIGANDS.1. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 31, pp. 1193-1198, ISSN:0022-152X DOI

Bruni F.; Selleri S.; Costanzo A.; Guerrini G.; Casilli M.L. (1994). Reactivity of 7‐(2‐dimethylaminovinyl)pyrazolo[1,5‐a]pyrimidines: Synthesis of pyrazolo[1,5‐a]pyrido[3,4‐e]pyrimidine derivatives as potential benzodiazepine receptor ligands. 1. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 31, pp. 1193-1198, ISSN:0022-152X DOI

A. COSTANZO; G. GUERRINI; F. BRUNI; S. SELLERI (1994). REACTIVITY OF 1-(2-NITROFENIL)-5-AMINOPYRAZOLES UNDER BASIC CONDITIONS AND SYNTHESIS OF NEW 3-, 7-, AND 8-SUBSTITUTED PYRAZOLO[5,1-C][1,2,4]BENZOTRIAZINE 5-OXIDES, AS BENZODIAZEPINE RECEPTOR LIGANDS.JOURNAL OF HETEROCYCLIC CHEMISTRY , - A. COSTANZO, G. GUERRINI, F. BRUNI, S. SELLERI. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 31, pp. 1369-1376, ISSN:0022-152X

S. CHIMICHI; B. COSIMELLI; F. BRUNI; S. SELLERI; A. COSTANZO; G. GUERRINI; G. VALLE (1994). CHEMISTRY OF SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINES PART 4. A STRUCTURAL CORRECTION OF A SERIES OF PYRAZOLO[5',1':2,3]PYRIMIDO[5,4-D][1,2]DIAZEPINES ON THE BASIS OF NMR SPECTROSCOPY AND X-RAY DIFFRACTION ANALYSIS .. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS II, vol. .., pp. 1657-1660, ISSN:0300-9580

Bruni F.; Cosimelli B.; Costanzo A.; Guerrini G.; Selleri S. (1993). 8H-pyrazolo[5′,1′:2,3]pyrimido[5,4-d][1,2]diazepine: A new tricyclic system. HETEROCYCLES, vol. 36, pp. 87-99, ISSN:0385-5414 DOI

F. BRUNI; A. COSTANZO; S. SELLERI; G. GUERRINI; R. FANTOZZI; R. PIRISINO; S. BRUNELLESCHI (1993). SYNTHESIS AND STUDY OF THE ANTIINFLAMMATORY PROPERTIES OF SOME PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES.. JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 82, pp. 480-486, ISSN:0022-3549

F. BRUNI; A. COSTANZO; S. SELLERI; G. GUERRINI; L. GIUSTI; C. MARTINI; A. LUCACCHINI (1993). SYNTHESIS OF 7-(2-DIMETHYLAMINOVINYL) DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINES, AS PRECURSOR OF NEW TRICYCLIC SERIES. BINDING STUDIES OF BDZ RECEPTOR.. IL FARMACO, vol. 48, pp. 309-319, ISSN:0014-827X

F. BRUNI; B. COSIMELLI; A. COSTANZO; G. GUERRINI; S. SELLERI (1993). 8H-PYRAZOLO[5',1':2,3]PYRIMIDO[5,4-D][1,2]DIAZEPINE. A NEW TRICYCLIC SYSTEM.. HETEROCYCLES, vol. 36, pp. 87-99, ISSN:0385-5414

Bruni F.; Costanzo A.; Selleri S.; Guerrini G.; Fantozzi R.; Pirisino R.; Brunelleschi S. (1993). Synthesis and study of the anti‐inflammatory properties of some pyrazolo[1,5‐a]pyrimidine derivatives. JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 82, pp. 480-486, ISSN:1520-6017 DOI

Bruni F.; Costanzo A.; Selleri S.; Guerrini G.; Giusti L.; Martini C.; Lucacchini A. (1993). Synthesis of 7-(2-dimethylaminovinyl) derivatives of pyrazolo[1,5-a]pyrimidines, as precursors of new tricyclic series. Binding studies of BDZ receptor. IL FARMACO, vol. 48, pp. 309-319, ISSN:0014-827X Accesso ONLINE all'editore

S. CHIMICHI; B.COSIMELLI; F.BRUNI; S.SELLERI (1992). 1H and 13C NMR Study of the Pyrazolo[1,5-a]pyrimidine System. CANADIAN JOURNAL OF CHEMISTRY, vol. 70, pp. 1093-1097, ISSN:0008-4042, NRC Research Press:National Research Council Canada, Ottawa Ontario K1A 0R6 Canada:(613)990-7873, (613)990-7873, (613)990-7873, (613)993-9084, (613)993-9084, EMAIL: eileen.evans-nantais@nrc-cnrc.gc.ca, INTERNET: http://www.researchpress.nrc.ca, Fax: (613)952-7656:

A. Costanzo; F. Bruni; G. Guerrini; S. Selleri; P.M. Aiello; C. Lamberti (1992). Synthesis of derivatives of pyrazolo[1,5-a]pyrrolo[1,2-c] [1,3,6]benzotriazocine.. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 29, pp. 1499-1505, ISSN:0022-152X

S. Selleri; F. Bruni; A. Costanzo; G. Guerrini; P. Malmberg Aiello; G. Iavarone; C. Martini (1992). Synthesis and preliminary evaluation of pyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-6(7H)ones and related compounds, as benzodiazepine receptor ligands and anticonvulsant agents.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 27, pp. 985-990, ISSN:0223-5234

Costanzo A.; Bruni F.; Guerrini G.; Selleri S.; Aiello P.M.; Lamberti C. (1992). Synthesis of derivatives of pyrazolo[1,5-α]pyrrolo[1,2-c][1,3,6]-benzotriazocine, a new class of compounds with potential cns activity. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 29, pp. 1499-1505, ISSN:1943-5193 Accesso ONLINE all'editore

Chimichi S.; Cosimelli B.; Bruni F.; Selleri S. (1992). Unambiguous structure determination of some pyrazolo [1,5‐a]pyrimidine derivatives by multinuclear NMR spectroscopy. MAGNETIC RESONANCE IN CHEMISTRY, vol. 30, pp. 1117-1121, ISSN:0749-1581 DOI

S. CHIMICHI; B.COSIMELLI; F.BRUNI; S.SELLERI (1992). Unambiguous Structure Determination of Some Pyrazolo[1,5-a]pyrimidine Deri-vatives by Multinuclear NMR Spectroscopy. MAGNETIC RESONANCE IN CHEMISTRY, vol. 30, pp. 1117-1121, ISSN:0749-1581, John Wiley & Sons Limited:1 Oldlands Way, Bognor Regis, P022 9SA United Kingdom:011 44 1243 779777, EMAIL: cs-journals@wiley.co.uk, INTERNET: http://www.wiley.co.uk, Fax: 011 44 1243 843232:

F.BRUNI; S. CHIMICHI; B.COSIMELLI; A.COSTANZO; G.GUERRINI; S.SELLERI (1990). A New Entry to Pyrazolo[1,5-a]pyrido[3,4-e]pyrimidine Derivatives. HETEROCYCLES, vol. 31, pp. 1141-1149, ISSN:0385-5414, Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598:

F.BRUNI; S. CHIMICHI; B.COSIMELLI; A.COSTANZO; G.GUERRINI; S.SELLERI (1990). Pyrazolo[1,5-a]pyrido[3,4-e]pyrimidine: a New Heterocyclic Ring System. HETEROCYCLES, vol. 31, pp. 1635-1640, ISSN:0385-5414, Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598:

A. Costanzo; F. Bruni; G. Auzzi; S. Selleri; L. Pecori Vettori (1990). Synthesis of CNS Potentially Active Bicyclic and Tricyclic Derivatives of Pyrazolo[1,5-a][1,3] diazepines.. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 27, pp. 695-697, ISSN:0022-152X

G. Auzzi; A. Costanzo; F. Bruni; M. Clauser; G. Guerrini; S. Selleri; L. Pecori Vettori (1990). Synthesis of 3-(1,3,4-thiadiazol-2-yl)pyrazolo[1,5-a]pyrimidine derivatives as potential antimicrobial agents.. IL FARMACO, vol. 45, pp. 1193-1205, ISSN:0014-827X

G. Orzalesi; P. Gratteri; S. Selleri (1990). Synthesis of new 1,3- dicyclohexyl barbituric acid derivatives with anti-inflammatory potential activity.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 25, pp. 197-201, ISSN:0223-5234

Mascini M.; Selleri S. (1989). Glucose biosensor with extended linearity.. ANALYTICAL LETTERS, vol. 22, pp. 1429-1449, ISSN:0003-2719

M. Mascini; S. Selleri; M. Riviello (1989). Glucose electrochemical probe with extended linearity for whole blood.. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 12, pp. 1507-1512, ISSN:0731-7085

G. Orzalesi; S. Selleri; P. Gratteri; S. Pinzauti (1989). Chromatographic analysis of picotamide and its impurities. INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 52, pp. 225-229, ISSN:0378-5173

Maggi C.A.; Giuliani S.; Santicioli P.; Selleri S.; Meli A (1989). The motor response to ethylendiamine of the rat isolated duodenum: Involvement of GABAergic transmission?. NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY, vol. 340, pp. 419-423, ISSN:0028-1298

Mascini M.; Selleri S.; Riviello M. (1989). Glucose electrochemical probe with extended linearity for whole blood. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 7, pp. 1507-1512, ISSN:0731-7085 DOI

Maggi C.A.;Patacchini R. Santicioli P.; Lippe I. T.; Giuliani S.; Geppetti P.; Del Bianco E.; Selleri S.; Meli A. (1988). The effect of omega conotoxin GVIA, a peptide modulator of the N-type voltage sensitive calcium channels, on motor responses produced by activation of efferent and sensory nerves in mammalian smooth muscle.. NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY, vol. 338, pp. 107-113, ISSN:0028-1298