Tecniche di rigenerazione di tessuti e organi:
-  Lunedì ore 9-10

Meccanismi di regolazioe della rigenerazione tissutale
-  Lunedì ore 10-11

Metodologia analitica applicata e Tecniche di laboratorio in Anatomia patologica
-  Lunedì ore 11-12

1989 Laurea in Scienze Biologiche presso la Facoltà di Scienze Matematiche Fisiche e Naturali dell’Università degli Studi di Firenze;

1990 abilitazione all’esercizio della professione di Biologo;

1991-1996 Borsista presso il Dipartimento di Fisiopatologia Clinica, Università degli studi di Firenze;

1997 assistente tecnico, VI qualifica professionale presso il Dipartimento di Fisiopatologia Clinica, Università degli studi di Firenze;

2005 ricercatore a tempo indeterminato in Medicina Interna (settore scientifico disciplinare MED09) presso la Facoltà di Medicina e Chirurgia dell’Università degli Studi di Firenze

2015 professore associato settore scientifico disciplinare MED46

2021 abilitazione nazionale I fascia settore scientifico disciplinare MED46 

1997 a oggi Dirigente biologo presso la Azienda Ospedaliero-Universitaria Careggi

1. 1989 Laurea in Scienze Biologiche presso la Facoltà di Scienze Matematiche Fisiche e Naturali dell’Università degli Studi di Firenze;

   1990 abilitazione all’esercizio della professione di Biologo;

   1991-1996 Borsista presso il Dipartimento di Fisiopatologia Clinica, Università degli studi di Firenze;

   1997 assistente tecnico, VI qualifica professionale presso il Dipartimento di Fisiopatologia Clinica, Università degli studi di Firenze;

   2005 ricercatore a tempo indeterminato in Medicina Interna (settore scientifico disciplinare MED09) presso la Facoltà di Medicina e Chirurgia dell’Università degli Studi di Firenze

   2015 professore associato settore scientifico disciplinare MED46

   2021 abilitazione nazionale I fascia settore scientifico disciplinare MED46 

   1997 a oggi Dirigente biologo presso la Azienda Ospedaliero-Universitaria Careggi

    

   partecipazione programmi di ricerca europei, nazionali e locali:

   • 2022-2024: Responsabile di unità di ricerca European Union – NextGenerationEU – National Recovery and Resilince Plan, Mission 4 Component 2 – Investment 1.5 - THE – Tuscany Health Ecosystem – ECS00000017
   • 2020-2021- Responsabile Progetto Dipartimento di Eccellenza Medicina di Genere dal titolo Renal progenitor cells and gender differences in chronic kidney disease
   • 2020-2025 : Partecipante al progetto europeo ERC Advanced Grant “SIMPOSION” ERC-2020-AdG
   • 2015 – 2019: Partecipante al progetto europeo ERC Consolidator Grant ERC-2014 CoG-648274_Renoir. “Renal progenitors: Tools for modeling and targets for treatment of kidney disorders”
   • 2013 – 2016 Partecipante al progetto europeo European Cooperative Grant FP7, KIDNEY CONNECT, “A gateway to European kidney research resources”, Grant number 602422
   • 2012 – 2017 Partecipante al progetto europeo European Cooperative Grant FP7, STELLAR, “Stem-cell based therapy for kidney repair” Grant number 305436
   • 2008 – 2012 Partecipante al progetto europeo ERC Starting Grant Young Investigator Award, RESCARF, Renal stem cells: possible role in kidney pathologies and as new therapeutic tools. Grant number 205027
   • 2008 – 2011     Partecipante al progetto europeo European Cooperative Grant Seventh Framework programme theme-Health-2007-1.4-8 FP7 Program, STAR-T REK, Set up and comparison of multiple stem cell approaches for kidney repair. Grant number 223007
   • 2009-2011 Partecipante in qualità di vice responsabile del Programma per la ricerca Regionale in Materia di Salute 2009 – Regione Toscana, “Renal stem cells amplification from the urine of patients with glomerular disorders for the set-up of autologous cell therapy of chronic renal injury.”
   • 2008-2010. Partecipante in qualità di vice responsabile del Progetto PRIN 2008- prot. 2008M9WSJX_001 “Stem cell-based therapy and de novo kidney organogenesis for treatment of chronic renal failure”
   • 2007-2009: Partecipante al progetto AIRC “Renal cancer stem cells: isolation, characterization and comparison with normal renal stem cells”.

    BREVETTI

   • Titolare del Brevetto per invenzione industriale dal titolo: Metodica per l’isolamento, purificazione ed amplificazione di progenitori renali CD133+CD24+ dalle urine di pazienti affetti da malattie renali. No. PCT/IB2014/067271. Inventori designati: Elena Lazzeri, Paola Romagnani, Laura Lasagni.

    

1989 Degree in Biological Sciences at the Faculty of Mathematical, Physical and Natural Sciences of the University of Florence;

1991-1996 Fellow at the Department of Clinical Pathophysiology, University of Florence;

1997 technical assistant, VI professional qualification at the Department of Clinical Physiopathology, University of Florence;

2005 researcher in Internal Medicine (MED09 scientific disciplinary sector) at the Faculty of Medicine and Surgery of the University of Florence

2015 associate professor scientific disciplinary sector MED46

1997 to date Biologist manager at the Careggi University Hospital

1989 Degree in Biological Sciences at the Faculty of Mathematical, Physical and Natural Sciences of the University of Florence;

1991-1996 Fellow at the Department of Clinical Pathophysiology, University of Florence;

1997 technical assistant, VI professional qualification at the Department of Clinical Physiopathology, University of Florence;

2005 researcher in Internal Medicine (MED09 scientific disciplinary sector) at the Faculty of Medicine and Surgery of the University of Florence

2015 associate professor scientific disciplinary sector MED46

1997 to date Biologist manager at the Careggi University Hospital

Participation in European, national and local research programs:

2022-2024: Head of research unit European Union – NextGenerationEU – National Recovery and Resilince Plan, Mission 4 Component 2 – Investment 1.5 - THE – Tuscany Health Ecosystem – ECS00000017
2020-2021- Project Manager Department of Excellence in Gender Medicine entitled Renal progenitor cells and gender differences in chronic kidney disease
2020-2025 : Participant in the European ERC Advanced Grant project “SIMPOSION” ERC-2020-AdG
2015 – 2019: Participant in the European project ERC Consolidator Grant ERC-2014 CoG-648274_Renoir. “Renal progenitors: Tools for modeling and targets for treatment of kidney disorders”
2013 – 2016 Participant in the European Cooperative Grant FP7 project, KIDNEY CONNECT, “A gateway to European kidney research resources”, Grant number 602422
2012 – 2017 Participant in the European Cooperative Grant FP7 project, STELLAR, “Stem-cell based therapy for kidney repair” Grant number 305436
2008 – 2012 Participant in the European project ERC Starting Grant Young Investigator Award, RESCARF, Renal stem cells: possible role in kidney pathologies and as new therapeutic tools. Grant number 205027
2008 – 2011 Participant in the European project European Cooperative Grant Seventh Framework program theme-Health-2007-1.4-8 FP7 Program, STAR-T REK, Set up and comparison of multiple stem cell approaches for kidney repair. Grant number 223007
2009-2011 Participant as deputy head of the Program for Regional Research in Health Matters 2009 – Tuscany Region, “Renal stem cells amplification from the urine of patients with glomerular disorders for the set-up of autologous cell therapy of chronic kidney injury .”
2008-2010. Participant as deputy manager of the PRIN 2008 project - prot. 2008M9WSJX_001 “Stem cell-based therapy and de novo kidney organogenesis for treatment of chronic renal failure”
2007-2009: Participant in the AIRC project “Renal cancer stem cells: isolation, characterization and comparison with normal renal stem cells”.

PATENTS

Patent for industrial invention entitled: Method for the isolation, purification and amplification of CD133+CD24+ renal progenitors from the urine of patients suffering from kidney disease. No. PCT/IB2014/067271. Designated inventors: Elena Lazzeri, Paola Romagnani, Laura Lasagni.

 Publications

1. Melica, M. E., Angelotti, M. L., Antonelli, G., Peired, A. J., Conte, C., De Chiara, L., Mazzinghi, B., Lazzeri, E., Lasagni, L. and Romagnani, P. Preparation of Human Kidney Progenitor Cultures and Their Differentiation into Podocytes. Bio-protocol 2023, 13(16): e4757
2. De Chiara L, Conte C, Semeraro R, Diaz-Bulnes P, Angelotti ML, Mazzinghi B, Molli A, Antonelli G, Landini S, Melica ME, Peired AJ, Maggi L, Donati M, La Regina G, Allinovi M, Ravaglia F, Guasti D, Bani D, Cirillo L, Becherucci F, Guzzi F, Magi A, Annunziato F, Lasagni L, Anders HJ, Lazzeri E, Romagnani P. Tubular cell polyploidy protects from lethal acute kidney injury but promotes consequent chronic kidney disease. Nat Commun. 2022 Oct 4;13(1):5805.
3. Ravaglia F, Melica M.E., Angelotti M.L., De Chiara L., Romagnani,P., Lasagni L. The pathology lesion patterns of podocytopathies: how and why?Front Cell Dev Biol. 2022;10:838272.
4. Melica ME, Antonelli G, Semeraro R, Angelotti ML, Lugli GM, Landini S, Ravaglia F, La Regina G, Conte C, De Chiara L, Peired A J, Mazzinghi B, Donati M, Molli A, Steiger S, Magi A, Bartalucci N, Raglianti V, Guzzi F, Maggi L, Annunziato F, Burger A, Lazzeri E, Anders HJ, Lasagni L* and Paola Romagnani*. Differentiation of crescent-forming kidney progenitor cells into podocytes attenuates severe glomerulonephritis in mice. Sci Transl Med 2022, 14(657): eabg3277. *Contributed equally.
5. Sobreiro-Almeida R, Melica ME, Lasagni L, Romagnani P, Neves NM. Retinoic Acid Benefits Glomerular Organotypic Differentiation from Adult Renal Progenitor Cells In Vitro. Stem Cell Rev Rep. 2021, 17(4), pp. 1406–1419
6. Peired AJ, Melica ME, Molli A, Nardi C, Romagnani P, Lasagni L. Molecular Mechanisms of Renal Progenitor Regulation: How Many Pieces in the Puzzle? Cells. 2021 Jan 2;10(1):59
7. Sobreiro-Almeida R, Maria E. Melica, Laura Lasagni, Hugo Osório, Paola Romagnani, Nuno M Neves. Particulate kidney extracellular matrix: bioactivity and proteomic analysis of a novel scaffold from porcine origin. Biomaterials Science, 2021, 9(1), pp. 186–198
8. Sobreiro-Almeida R, Melica ME, Lasagni L, Romagnani P, Neves NM. Co-cultures of renal progenitors and endothelial cells on kidney decellularized matrices replicate the renal tubular environment in vitro. Acta Physiol (Oxf) . 2020, 230(1), e13491
9. Peired AJ, Antonelli G, Angelotti ML, Allinovi M, Guzzi F, Sisti A, Semeraro R, Conte C, Mazzinghi B, Nardi S, Melica ME, De Chiara L, Lazzeri E, Lasagni L, Lottini T, Landini S, Giglio S, Mari A, Di Maida F, Antonelli A, Porpiglia F, Schiavina R, Ficarra V, Facchiano D, Gacci M, Serni S, Carini M, Netto GJ, Roperto RM, Magi A, Christiansen CF, Rotondi M, Liapis H, Anders HJ, Minervini A, Raspollini MR, Romagnani P. Acute kidney injury promotes development of papillary renal cell adenoma and carcinoma from renal progenitor cells. Sci Transl Med. 2020 Mar 25;12(536):eaaw6003.
10. Anna Julie Peired, Benedetta Mazzinghi, Letizia De Chiara, Francesco Guzzi, Laura Lasagni, Paola Romagnani, Elena Lazzeri. Bioengineering Strategies for Nephrologists: Kidney Was Not Built in a Day. Expert Opin Biol Ther., 2020; 20(5):467-480.
11. Maria Elena Melica, Gilda La Regina, Matteo Parri, Anna Julie Peired, Paola Romagnani, Laura Lasagni. Substrate Stiffness Modulates Renal Progenitor Cell Properties via a ROCK-Mediated Mechanotransduction Mechanism. Cells, 8 (12) 2019
12. Simone Romoli, Maria Lucia Angelotti, Giulia Antonelli, Santhosh Kumar Vr, Shrikant R Mulay, Jyaysi Desai, Lidia Anguiano Gomez, Dana Thomasova, Dirk Eulberg, Sven Klussmann, Maria Elena Melica, Carolina Conte, Duccio Lombardi, Laura Lasagni, Hans-Joachim Anders, Paola Romagnani. CXCL12 Blockade Preferentially Regenerates Lost Podocytes in Cortical Nephrons by Targeting an Intrinsic Podocyte-Progenitor Feedback Mechanism. Kidney Int, 94 (6), 1111-1126, 2018
13. E. Lazzeri, M.L. Angelotti, A. Peired, C. Conte, J.A Marschner, L. Maggi, B. Mazzinghi, D. Lombardi, M.E. Melica, S. Nardi, E. Ronconi, A. Sisti, G. Antonelli, F. Becherucci, L. De Chiara, R. Romero Guevara, A. Burger, B. Schaefer, F. Annunziato, H.J. Anders, L. Lasagni, Paola Romagnani. Endocycle-related Tubular Cell Hypertrophy and Progenitor Proliferation Recover Renal Function After Acute Kidney Injury. Nat Commun. 9 (1), 1344, 2018.
14. Romagnani P., Lasagni L. Modeling the glomerular filtration barrier:  are you kidney-ing me? Cell Stem Cell, 21 (1), 7-9.
15. Lasagni L, Angelotti ML, Ronconi E, Lombardi D, Nardi S, Peired A, Becherucci F, Mazzinghi B, Sisti A, Romoli S, Burger A, Schaefer B, Buccoliero A, Lazzeri E, Romagnani P. Podocyte Regeneration Driven by Renal Progenitors Determines Glomerular Disease Remission and Can Be Pharmacologically Enhanced. Stem Cell Reports. 2015;5:248-63. (I.F. 5.365)
16. Lazzeri E, Romagnani P, Lasagni L. Stem cell therapies in kidney disease. Expert Opin Biol Ther. 2015, 15(10), pp. 1455–1468
17. Bussolati B, Maeshima A, Peti-Peterdi J, Yokoo T, Lasagni L. Renal Stem Cells, Tissue Regeneration, and Stem Cell Therapies for Renal Diseases (TIRE). Editoriale Stem Cells International, vol. 2015 (I.F. 2.806)
18. Lombardi D, Lasagni L. Transgenic Strategies to Study Podocyte Loss and Regeneration. Stem Cells International, vol. 2015, Article ID 678347, 13 pages, 2015. doi:10.1155/2015/678347. (I.F. 2.806)
19. Lazzeri E, Ronconi E, Angelotti ML, Peired A, Mazzinghi B, Becherucci F, Conti S, Sansavini G, Sisti A, Ravaglia F, Lombardi D, Provenzano A, Manonelles A, Cruzado JM, Giglio S, Roperto RM, Materassi M, Lasagni L, Romagnani P. Human Urine-Derived Renal Progenitors for Personalized Modeling of Genetic Kidney Disorders. J Am Soc Nephrol. 2015, 26(8), 1961-1974
20. Lazzeri E, Peired AJ, Lasagni L, Romagnani P. Retinoids and glomerular regeneration. Semin Nephrol. 2014 Jul;34(4):429-36. (I.F. 2.942)
21. Giglio S, Provenzano A, Mazzinghi B, Becherucci F, Giunti L, Sansavini G, Ravaglia F, Roperto RM, Farsetti S, Benetti E, Rotondi M, Murer L, Lazzeri E, Lasagni L, Materassi M, Romagnani P. Heterogeneous genetic alterations in sporadic nephrotic syndrome associate with resistance to immunosuppression. J Am Soc Nephrol. 2015 Jan;26(1):230-6. (I.F. 9.663)
22. Peired A, Lazzeri E, Lasagni L, Romagnani P. Glomerular regeneration: when can the kidney regenerate from injury and what turns failure into success? Nephron Exp Nephrol. 2014;126(2):70. (I.F. 1.649)
23. Lasagni L, Romagnani P. Basic research: Podocyte progenitors and ectopic podocytes. Nat Rev Nephrol. 2013 Dec;9(12):715-6. (I.F. 8.368)
24. Peired A, Angelotti ML, Ronconi E, la Marca G, Mazzinghi B, Sisti A, Lombardi D, Giocaliere E, Della Bona M, Villanelli F, Parente E, Ballerini L, Sagrinati C, Wanner N, Huber TB, Liapis H, Lazzeri E, Lasagni L, Romagnani P. Proteinuria impairs podocyte regeneration by sequestering retinoic acid. J Am Soc Nephrol. 2013 Nov;24(11):1756-68. (I.F. 9.663)
25. Mulay SR, Thomasova D, Ryu M, Kulkarni OP, Migliorini A, Bruns H, Gröbmayr R, Lazzeri E, Lasagni L, Liapis H, Romagnani P, Anders HJ. Podocyte loss involves MDM2-driven mitotic catastrophe. J Pathol. 2013 Jul;230(3):322-35. (I.F. 7.330)
26. Lasagni L, Lazzeri E, Shankland SJ, Anders HJ, Romagnani P. Podocyte mitosis - a catastrophe. Curr Mol Med. 2013 Jan;13(1):13-23. (I.F. 3.612)
27. Angelotti ML, Ronconi E, Peired A, Mazzinghi B, Lazzeri E, Lasagni L, Romagnani P. Tubular progenitor cells: new protagonists of tubular regeneration. G Ital Nefrol. 2012 Sep-Oct;29(5):514-8.
28. Angelotti ML, Ronconi E, Ballerini L, Peired A, Mazzinghi B, Sagrinati C, Parente E, Gacci M, Carini M, Rotondi M, Fogo AB, Lazzeri E, Lasagni L, Romagnani P. Characterization of renal progenitors committed toward tubular lineage and their regenerative potential in renal tubular injury. Stem Cells. 2012 Aug;30(8):1714-25. (I.F. 7.133)

9. Lasagni L, Sagrinati C, Ronconi E, Angelotti ML, Parente E, Ballerini L, Peired A, Romagnani P. Novel strategies of regenerative medicine using chemical compounds. Curr Med Chem. 2010;17(34):4134-49 (I.F. 3.715)
10. Lasagni L, Romagnani P Glomerular epithelial stem cells: the good, the bad, and the ugly. J Am Soc Nephrol. 2010 Oct;21(10):1612-9. (I.F. 9.663)
11. Lasagni L, Ballerini L, Angelotti ML, Parente E, Sagrinati C, Mazzinghi B, Peired A, Ronconi E, Becherucci F, Bani D, Gacci M, Carini M, Lazzeri E, Romagnani P. Notch activation differentially regulates renal progenitors proliferation and differentiation toward the podocyte lineage in glomerular disorders. Stem Cells. 2010 Sep;28(9):1674-85. (I.F. 7.133)
12. Angelotti ML, Lazzeri E, Lasagni L, Romagnani P. Only anti-CD133 antibodies recognizing the CD133/1 or the CD133/2 epitopes can identify human renal progenitors. Kidney Int. 2010 Sep;78(6):620-1 (I.F. 8.520)
13. Ronconi E, Mazzinghi B, Sagrinati C, Angelotti ML, Ballerini L, Parente E, Romagnani P, Lazzeri E, Lasagni L. [The role of podocyte damage in the pathogenesis of glomerulosclerosis and possible repair mechanisms.] G Ital Nefrol. 2009 Nov-Dec;26(6):660-9.
14. Smeets B, Angelotti ML, Rizzo P, Dijkman H, Lazzeri E, Mooren F, Ballerini L, Parente E, Sagrinati C, Mazzinghi B, Ronconi E, Becherucci F, Benigni A, Steenbergen E, Lasagni L, Remuzzi G, Wetzels J, Romagnani P. Renal progenitor cells contribute to hyperplastic lesions of podocytopathies and crescentic glomerulonephritis. J Am Soc Nephrol. 2009 Dec;20(12):2593-603. (I.F. 9.663)
15. Becherucci F, Mazzinghi B, Ronconi E, Peired A, Lazzeri E, Sagrinati C, Romagnani P, Lasagni L. The role of endothelial progenitor cells in acute kidney injury. Blood Purif. 2009;27(3):261-70. (I.F. 1.920)
16. Ronconi E, Sagrinati C, Angelotti ML, Lazzeri E, Mazzinghi B, Ballerini L, Parente E, Becherucci F, Gacci M, Carini M, Maggi E, Serio M, Vannelli GB, Lasagni L, Romagnani S, Romagnani P. Regeneration of glomerular podocytes by human renal progenitors. J Am Soc Nephrol. 2009 Feb;20(2):322-32, (I.F. 9.663)
17. E.L azzeri, M.L.Angelotti, L.Ballerini, F.Becherucci, B.Mazzinghi, E.Parente, E.Ronconi, C.Sagrinati, P.Romagnani, L.Lasagni. Ruolo dei progenitori endoteliali nelle malattie renali. G Ital Nefrol. 2008 Sep-Oct;25(5):537-46
18. Sagrinati C, Ronconi E, Lazzeri E, Lasagni L, Romagnani P. Stem-cell approaches for kidney repair: choosing the right cells. Trends Mol Med 2008, 14(7), pp. 277–285.
19. Liotta F, Frosali F, Querci V, Mantei A, Filì L, Maggi L, Mazzinghi B, Angeli R, Ronconi E, Santarlasci V, Biagioli T, Lasagni L, Ballerini C, Parronchi P, Scheffold A, Cosmi L, Maggi E, Romagnani S, Annunziato F. Human immature myeloid dendritic cells trigger a TH2-polarizing program via Jagged-1/Notch interaction. J Allergy Clin Immunol. 2008 Apr;121(4):1000-5.e8 (I.F. 11.248)
20. Petrai I, Rombouts K, Lasagni L, Annunziato F, Cosmi L, Romanelli RG, Sagrinati C, Mazzinghi B, Pinzani M, Romagnani S, Romagnani P, Marra F. Activation of p38(MAPK) mediates the angiostatic effect of the chemokine receptor CXCR3-B. Int J Biochem Cell Biol. 2008;40(9):1764-74 (I.F. 4.240)
21. Mazzinghi B, Ronconi E, Lazzeri E, Sagrinati C, Ballerini L, Angelotti ML, Parente E, Mancina R, Netti GS, Becherucci F, Gacci M, Carini M, Gesualdo L, Rotondi M, Maggi E, Lasagni L, Serio M, Romagnani S, Romagnani P Essential but differential role for CXCR4 and CXCR7 in the therapeutic homing of human renal progenitor cells. J Exp Med. 2008 Feb 18;205(2):479-90. (I.F. 13.912)
22. Lazzeri E, Crescioli C, Ronconi E, Mazzinghi B, Sagrinati C, Netti GS, Angelotti ML, Parente E, Ballerini L, Cosmi L, Maggi L, Gesualdo L, Rotondi M, Annunziato F, Maggi E, Lasagni L, Serio M, Romagnani S, Vannelli GB, Romagnani P. Regenerative potential of embryonic renal multipotent progenitors in acute renal failure. J Am Soc Nephrol. 2007 Dec;18(12):3128-38. (I.F. 9.663)
23. Sagrinati C, Netti GS, Mazzinghi B, Lazzeri E, Liotta F, Frosali F, Ronconi E, Meini C, Gacci M, Squecco R, Carini M, Gesualdo L, Francini F, Maggi E, Annunziato F, Lasagni L, Serio M, Romagnani S, Romagnani P. Isolation and characterization of multipotent progenitor cells from the Bowman's capsule of adult human kidneys. J Am Soc Nephrol 17:2443-2456, 2006. (I.F. 9.663)
24. Romagnani P, Lasagni L, Mazzinghi B, Lazzeri E, Romagnani S. Pharmacological modulation of stem cell function. Curr Med Chem. 2007;14(10):1129-39. (I.F. 3.715)
25. Lasagni L, Grepin R, Mazzinghi B, Lazzeri E, Meini C, Sagrinati C, Liotta F, Frosali F, Ronconi E, Alain-Courtois N, Ballerini L, Netti GS, Maggi E, Annunziato F, Serio M, Romagnani S, Bikfalvi A, Romagnani P. PF-4/CXCL4 and CXCL4L1 exhibit distinct subcellular localization and a differentially regulated mechanism of secretion. Blood. 2007 May 15;109(10):4127-34. (I.F. 9.775).
26. Giuliani N, Bonomini S, Romagnani P, Lazzaretti M, Morandi F, Colla S, Tagliaferri S, Lasagni L, Annunziato F, Crugnola M, Rizzoli V. CXCR3 and its binding chemokines in myeloma cells: expression of isoforms and potential relationships with myeloma cell proliferation and survival. Haematologica. 2006 Nov;91(11):1489-97. (I.F. 5.868)
27. Romagnani P, Lasagni L, Romagnani S. Peripheral blood as a source of stem cells for regenerative medicine. Expert Opin Biol Ther. 2006 Mar;6(3):193-202 (I.F. 3.653)
28. Annunziato F, Cosmi L, Liotta F, Lazzeri E, Romagnani P, Angeli R, Lasagni L, Manetti R, Marra F, Gerard C, Petrai I, Dello Sbarba P, Tonelli F, Maggi E, Romagnani S. CXCR3 and alphaEbeta7 integrin identify a subset of CD8+ mature thymocytes that share phenotypic and functional properties with CD8+ gut intraepithelial lymphocytes. Gut. 2006 Jul;55(7):961-8. (I.F. 13.319)
29. Romagnani P, Maggi L, Mazzinghi B, Cosmi L, Lasagni L, Liotta F, Lazzeri E, Angeli R, Rotondi M, Fili L, Parronchi P, Serio M, Maggi E, Romagnani S, Annunziato F CXCR3-mediated opposite effects of CXCL10 and CXCL4 on TH1 or TH2 cytokine production. J Allergy Clin Immunol. 2005 Dec;116(6):1372-9. (I.F. 11.248)
30. Romagnani P, Lazzeri E, Mazzinghi B, Lasagni L, Guidi S, Bosi A, Cirami C, Salvadori M. Nephrotic syndrome and renal failure after allogeneic stem cell transplantation: novel molecular diagnostic tools for a challenging differential diagnosis. Am J Kidney Dis. 2005 Sep;46(3):550-6. (I.F. 5.756)
31. Romagnani P, Annunziato F, Liotta F, Lazzeri E, Mazzinghi B, Frosali F, Cosmi L, Maggi L, Lasagni L, Scheffold A, Kruger M, Dimmeler S, Marra F, Gensini G, Maggi E, Romagnani S. CD14+CD34low cells with stem cell phenotypic and functional features are the major source of circulating endothelial progenitors. Circ Res. 2005 Aug 19;97(4):314-22. (I.F. 11.089)
32. Pende D, Castriconi R, Romagnani P, Spaggiari GM, Marcenaro S, Dondero A, Lazzeri E, Lasagni L, Martini S, Rivera P, Capobianco A, Moretta L, Moretta A, Bottino C. Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction. Blood. 2006 Mar 1;107(5):2030-6. (I.F. 9.775).
33. Rotondi M, Rosati A, Buonamano A, Lasagni L, Lazzeri E, Pradella F, Fossombroni V, Cirami C, Lotta F, La Villa G, Serio M, Bretoni E, Salvatori M, Romagnani P. “High pretransplant serum levels of CXCL10/IP-10 are related to increased risk of renal allograft failure”. Am J Transplant Sep;4(9):1466-74 (I.F. 6.190)
34. Cosmi L, Liotta F, Angeli R, Mazzinghi B, Santarlasci V, Manetti R, Lasagni L, Vanini V, Romagnani P, Maggi E, Annunziato F, Romagnani S. Th2 cells are less susceptible than Th1 cells to the suppressive activity of CD25+ regulatory thymocytes because of their responsiveness to different cytokines. Blood. 2004 Apr 15;103(8):3117-21 (I.F. 9.775).
35. Romagnani P, Lasagni L, Annunziato F, Serio M, Romagnani S. CXC chemokines: the regulatory link between inflammation and angiogenesis. Trends Immunol. 2004 Apr;25(4):201-9 (I.F. 12.031)
36. Lasagni L., Francalanci M, Annunziato F, Lazzeri E, Giannini S, Cosmi L, Sagrinati C, Mazzinghi B, Orlando C, Maggi E, Marra F, Romagnani S, Serio M, and Romagnani P. “An alternatively spliced variant of CXCR3 mediates the IP-10, Mig, and I-TAC induced-inhibition of endothelial cell growth and acts as functional receptor for PF-4”. J Exp Med. 2003, 197(11), pp. 1537–1549. (I.F. 13.912). Questo articolo e’ stato valutato dalla Faculty of 1000 con il punteggio 4.8, Must read.
37. Lazzeri E, Lasagni L, Serio M, Romagnani S, Romagnani P. “Cytokines and chemokines in nephropathies and renal transplant”. G Ital Nefrol. 2002 Nov-Dec;19(6):641 9.
38. Romagnani P, Rotondi M, Lazzeri E, Lasagni L, Francalanci M, Buonamano A, Milani S, Vitti P, Chiovato L, Tonacchera M, Bellastella A and Serio M. “Expression of IP-10/CXCL10 and MIG/CXCL9 in the thyroid and increased levels of IP-10/CXCL10 in the serum of patients with recent-onset Graves’ disease”. Am J Pathol. Jul 2002; 161(1): 195-206. (I.F. 4.602)
39. Romagnani P, Lazzeri E, Lasagni L, Mavilia C, Beltrame C, Francalanci M, Rotondi M, Annunziato F, Maurenzig L, Cosmi L, Galli G, Salvadori M, Maggi E and Serio M. “IP-10 and Mig production by glomerular cells in human proliferative glomerulonephritis and their regulation by nitric oxide”. J Am Soc Nephrol. 2002 Jan; 13(1):53-64. (I.F. 9.663)
40. Bonacchi A, Romagnani P, Romanelli RG, Efsen E, Annunziato F, Lasagni L, Francalanci M, Serio M, Laffi G, Pinzani M, Gentilini P, Marra F. Signal transduction by the chemokine receptor CXCR3: activation of Ras/ERK, Src, and phosphatidylinositol 3-kinase/Akt controls cell migration and proliferation in human vascular pericytes. J Biol Chem. 2001 Mar 30;276(13):9945-54 (I.F. 4.600)
41. Romagnani P, Annunziato F, Lasagni L, Lazzeri E, Beltrame C, Francalanci M, Uguccioni M, Galli G, Cosmi L, Maurenzig L, Maggiolini M, Maggi E, Romagnani S and Serio M. “Cell-cycle dependent expression of CXC chemokine receptor 3 by endothelial cells mediates angiostatic activity”. J Clin Invest. 2001 Jan;107(1):53-63. Selezionato per la copertina della rivista. Oggetto di un editoriale da parte di John Ashkenas, Science Editor. (I.F. 13.765)
42. Romagnani P, Beltrame C, Annunziato F, Lasagni L, Luconi M, Galli G, Cosmi L, Maggi E, Salvadori M, Pupilli C, Serio M. Role for interactions between IP-10/Mig and CXCR3 in proliferative glomerulonephritis. J Am Soc Nephrol. 1999 Dec;10(12):2518-26. (I.F. 9.663)
43. Romagnani P, Pupilli C, Lasagni L, Baccari MC, Bellini F, Amorosi A, Bertoni E, Serio M. Inducible nitric oxide synthase expression in vascular and glomerular structures of human chronic allograft nephropathy. J Pathol. 1999 Feb;187(3):345-50. (I.F. 7.330)
44. Pupilli C, Lasagni L, Romagnani P, Bellini F, Mannelli M, Misciglia N, Mavilia C, Vellei U, Villari D, Serio M. Angiotensin II stimulates the synthesis and secretion of vascular permeability factor/vascular endothelial growth factor in human mesangial cells. J Am Soc Nephrol. 1999 Feb;10(2):245-55. (I.F. 9.663)
45. Romagnani P, Annunziato F, Manetti R, Mavilia C, Lasagni L, Manuelli C, Vannelli GB, Vanini V, Maggi E, Pupilli C, Romagnani S. High CD30 ligand expression by epithelial cells and Hassal's corpuscles in the medulla of human thymus. Blood. 1998 May 1;91(9):3323-32. (I.F. 9.775)
46. Pupilli C, Romagnani P, Lasagni L, Bellini F, Misciglia N, Emoto N, Yanagisawa M, Rizzo M, Mannelli M, Serio M. Localization of endothelin-converting enzyme-1 in human kidney. Am J Physiol. 1997 Nov;273(5 Pt 2):F749-56. (I.F. 3.300)
47. Frediani U, Becherini L, Lasagni L, Tanini A, Brandi ML Catecholamines modulate growth and differentiation of human preosteoclastic cells. Osteoporos Int. 1996;6(1):14-21. (I.F. 4.165)
48. Orlandini SZ, Formigli L, Benvenuti S, Lasagni L, Franchi A, Masi L, Bernabei PA, Santini V, Brandi ML. Functional and structural interactions between osteoblastic and preosteoclastic cells in vitro. Cell Tissue Res. 1995 Jul;281(1):33-42. (I.F. 3.333)
49. Calabresi E, Lasagni L, Franceschelli F, de Leonardis V, Becorpi A, Serio M, Brandi ML. Comparison of immuno- and HPLC-assays for the measurement of urinary collagen cross-links. J Endocrinol Invest. 1994 Sep;17(8):625-9. (I:F 1.552)
50. Calabresi E, Lasagni L, Franceschelli F, Bartolini L, Serio M, Brandi ML Use of an internal standard to measure pyridinoline and deoxypyridinoline in urine. Clin Chem. 1994 Feb;40(2):336-7. (I.F. 7.768)
51. Dolara P, Lodovici M, Fazi M, Lasagni L, Sturlini S. Protective effect of gangliosides on myocardial hypoxic damage in the rat. Eur J Pharmacol. 1991 May 30;198(1):43-9. (I.F. 2.684)

CAPITOLI SU LIBRI

1. Lasagni L, Lazzeri E, Peired A, Romagnani P. Kidney Development, Disease, Repair and Regeneration: Edited by Melissa Little, Elsevier 2015
2. Lazzeri E, Peired A, Ballerini L, Lasagni L. Adult stem cells in tissue homeostasis and disease: Current frontiers and perspectives in cell biology. Edited by Stevo Najmam, InTech, 2012
3. Lasagni L, Lazzeri E, Romagnani P. Stem cell niche in the kidney: Regenerative nephrology; pg. 233-243; Edited by M Goligorsky. Elsevier, 2011.
4. P. Romagnani, L. Lasagni, S. Romagnani. Chemokine function in tissue cells. In: Chemokine biology: Basic Research and Clinical Application. Edited by Bernard Moser, Gordon L. Letts and Kuldeep neote, 2006 Birkhauser Verlag Basel/Switzerland.