Marta FERRARONI

Ruolo attuale:: Professore Associato
SSD:: CHEM-03/A - Chimica generale e inorganica
Afferenza organizzativa:: Dipartimento di Chimica 'Ugo Schiff' - DICUS

Recapiti

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	marta.ferraroni(AT)unifi.it

Marta FERRARONI

Orario di ricevimento (aggiornato al 05/09/2022)

Tutti i giorni previo appuntamento al Dipartimento di Chimica- Polo Scientifico

Marta FERRARONI

Biografia

Marta Ferraroni è nata a Firenze nel 1965. Si è laureata in Chimica presso l'Università degli Studi Firenze nel 1992 con una tesi dal titolo “Interazione degli anioni con la Carbossipeptidasi A: uno studio cristallografico”. Relatore, Prof. Pierluigi Orioli. Ha ottenuto il Dottorato in Scienze chimiche nel 1997 Titolo della tesi: “Impiego della cristallografia ad alta risoluzione per uno studio meccanicistico sull’enzima Cu, Zn Superossido Dismutasi”. Tutor Prof. Stefano Mangani. Ha svolto poi attività di ricerca nel gruppo del Prof. K. Wilson, EMBL presso DESY ad Amburgo, Germania. Nel 1998 ha avuto una Borsa di Studio Post-Dottorato presso il Centro di Biologia Strutturale dell’Università dell’Alabama a Birmingham (Alabama, USA). Dal 1999 lavora presso il Dipartimento di Chimica dell'Università di Firenze.

Marta FERRARONI

Curriculum

Studi 1992-Laurea in Chimica, conseguita presso l’Università degli Studi di Firenze con la votazione di 110/110. 1996-Dottorato di Ricerca in Scienze Chimiche conseguito presso l’Università degli Studi di Firenze. Titolo della tesi: “Impiego della cristallografia ad alta risoluzione per uno studio meccanicistico sull’enzima Cu,Zn Superossido Dismutasi”. Febbraio 1998-Marzo 1999 - Borsa di Studio Post-Dottorato presso il Centro per la Biologia Strutturale dell’Università dell’Alabama a Birmingham, Alabama, USA. Soggiorni all’estero: Ottobre-Dicembre 1995, Luglio-Dicembre 1996, attività di ricerca nel gruppo del Prof. K. Wilson, EMBL presso DESY ad Amburgo, Germania. Incarico Attuale: Professore associato presso il Dipartimento di Chimica dell’Università di Firenze. Attività didattica M.F. è stata titolare del corso di Chimica Generale e Inorganica per il Corso di Laurea in Informazione scientifica sul farmaco, Facoltà di Farmacia. Inoltre è stata anche titolare di un modulo per il corso di Strutture delle Proteine, Corso di Laurea Specialistica in Biotecnologia Farmaceutica, Facoltà di Farmacia. Attualmente è titolare del corso di Chimica Generale e Inorganica del Corso di Laurea in Scienze della formazione primaria e di un modulo del corso di Chimica Generale e Inorganica del Corso di Laurea in Farmacia e in Scienze Geologiche.

Produzione scientifica: M.F. è coautrice di più di 100 articoli scientifici pubblicati su riviste di livello internazionale e di 5 capitoli di libro.

Marta FERRARONI

Interessi

M.F. svolge da oltre vent’anni la sua attività di ricerca nel settore della Chimica Bioinorganica e il suo interesse principale è la comprensione delle relazioni esistenti tra la struttura e ilmeccanismo di azione di metalloproteine coinvolte in processi di rilevante interesse biologico.
In particolare, l’attività di ricerca scientifica di M.F. si è concentrata in questi anni sullo studio di sistemi enzimatici ossidativi, ossigenasi ed ossidasi, implicati nei processi biodegradativi di sostanze aromatiche, e su una superfamiglia di enzimi, le Anidrasi carboniche (CAs), che catalizzano l’intenconversione di CO2 e bicarbonato.

Marta FERRARONI

Pubblicazioni

Legenda

Contributo su rivista |

Articolo su libro |

Libro |

Contributo in atti di convegno (proceeding) |

Brevetto |

Curatela | Altro

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Tesi di Dottorato

Chiara Baroni; Murat Bozdag; Gioele Renzi; Viviana De Luca; Clemente Capasso; Carla Bazzicalupi; Silvia Selleri; Marta Ferraroni; Fabrizio Carta; Claudiu T. Supuran (2025). X-ray crystallographic and kinetic studies of biguanide containing aryl sulfonamides as carbonic anhydrase inhibitors. RSC MEDICINAL CHEMISTRY, pp. 0-0, ISSN:2632-8682 DOI

Marinacci B.; D'Agostino I.; Angeli A.; Carradori S.; Melfi F.; Grande R.; Corsiani M.; Ferraroni M.; Agamennone M.; Tondo A.R.; Zara S.; Puca V.; Pellegrini B.; Vagaggini C.; Dreassi E.; Patrauchan M.A.; Capasso C.; Nicolotti O.; Carta F.; Supuran C.T. (2024). Inhibition of Pseudomonas aeruginosa Carbonic Anhydrases, Exploring Ciprofloxacin Functionalization Toward New Antibacterial Agents: An In-Depth Multidisciplinary Study. JOURNAL OF MEDICINAL CHEMISTRY, vol. 67, pp. 19077-19102, ISSN:1520-4804 DOI Accesso ONLINE all'editore

Angeli A.; Ferraroni M.; Capasso C.; Supuran C.T. (2024). The dopamine D2 receptors antagonist Veralipride inhibits carbonic anhydrases: solution and crystallographic insights on human isoforms. CHEMISTRY - AN ASIAN JOURNAL, vol. 19, pp. 0-0, ISSN:1861-471X DOI Accesso ONLINE all'editore

D'Agostino I.; Bonardi A.; Ferraroni M.; Gratteri P.; Angeli A.; Supuran C.T. (2024). Exploring the Polypharmacological Potential of PCI-27483: A Selective Inhibitor of Carbonic Anhydrases IX and XII. ACS MEDICINAL CHEMISTRY LETTERS, vol. 15, pp. 2042-2045, ISSN:1948-5875 DOI Accesso ONLINE all'editore

Giovannuzzi S.; Nikitjuka A.; Angeli A.; Smietana M.; Massardi M.-L.; Turati M.; Ronca R.; Bonardi A.; Nocentini A.; Ferraroni M.; Supuran C.T.; Winum J.-Y. (2024). Benzoxaborinine, New Chemotype for Carbonic Anhydrase Inhibition: Ex Novo Synthesis, Crystallography, In Silico Studies, and Anti-Melanoma Cell Line Activity. JOURNAL OF MEDICINAL CHEMISTRY, vol. 67, pp. 18221-18234, ISSN:1520-4804 DOI Accesso ONLINE all'editore

Hefny S.M.; El-Moselhy T.F.; El-Din N.; Ammara A.; Angeli A.; Ferraroni M.; El-Dessouki A.M.; Shaldam M.A.; Yahya G.; Al-Karmalawy A.A.; Supuran C.T.; Tawfik H.O. (2024). A new framework for novel analogues of pazopanib as potent and selective human carbonic anhydrase inhibitors: Design, repurposing rational, synthesis, crystallographic, in vivo and in vitro biological assessments. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 274, pp. 116527-116527, ISSN:1768-3254 DOI

Hakan Aslan; Gioele Renzi; Andrea Angeli; Ilaria D'Agostino; Roberto Ronca; Maria Luisa Massardi; Camilla Tavani; Simone Carradori; Marta Ferraroni; Paolo Governa; Fabrizio Manetti; Fabrizio Carta; Claudiu T. Supuran (2024). Benzenesulfonamide decorated dihydropyrimidin(thi)ones: carbonic anhydrase profiling and antiproliferative activity. RSC MEDICINAL CHEMISTRY, vol. 15, pp. 1929-1941, ISSN:2632-8682 DOI Accesso ONLINE all'editore

Angeli A.; Chelli I.; Lucarini L.; Sgambellone S.; Marri S.; Villano S.; Ferraroni M.; De Luca V.; Capasso C.; Carta F.; Supuran C.T. (2024). Novel Carbonic Anhydrase Inhibitors with Dual-Tail Core Sulfonamide Show Potent and Lasting Effects for Glaucoma Therapy. JOURNAL OF MEDICINAL CHEMISTRY, vol. 67, pp. 3066-3089, ISSN:0022-2623 DOI

Ferraroni M. (2024). Bacterial β-carbonic anhydrases. THE ENZYMES, vol. 55, pp. 65-91, ISSN:1874-6047 DOI

Baroni C.; D'Agostino I.; Renzi G.; Kilbile J.T.; Tamboli Y.; Ferraroni M.; Carradori S.; Capasso C.; Carta F.; Supuran C.T. (2024). Lasamide, a Potent Human Carbonic Anhydrase Inhibitor from the Market: Inhibition Profiling and Crystallographic Studies. ACS MEDICINAL CHEMISTRY LETTERS, vol. 15, pp. 1749-1755, ISSN:1948-5875 DOI

Lucarini, Elena; D'Antogiovanni, Vanessa; Antonioli, Luca; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo; Ferraroni, Marta; Locuoco, Maria; Capperucci, Antonella; Tanini, Damiano; Angeli, Andrea; Supuran, Claudiu T. (2024). Study of Chalcogen Aspirin Derivatives with Carbonic Anhydrase Inhibitory Properties for Treating Inflammatory Pain. ACS MEDICINAL CHEMISTRY LETTERS, pp. 0-0, ISSN:1948-5875 DOI

Marjan Sobati; Morteza Abdoli; Andrea Angeli; Alessandro Bonardi; Marta Ferraroni; Claudiu T Supuran; Raivis Žalubovskis (2024). Sulfonamide-incorporated bis(α-aminophosphonates) as promising carbonic anhydrase inhibitors: Design, synthesis, biological evaluation, and X-ray crystallographic studies. ARCHIV DER PHARMAZIE, pp. 1-11, ISSN:0365-6233 DOI

Al-Matarneh, Cristina M.; Pinteala, Mariana; Nicolescu, Alina; Silion, Mihaela; Mocci, Francesca; Puf, Razvan; Angeli, Andrea; Ferraroni, Marta; Supuran, Claudiu T.; Zara, Susi; Carradori, Simone; Paoletti, Niccolò; Bonardi, Alessandro; Gratteri, Paola (2024). Synthetic Approaches to Novel Human Carbonic Anhydrase Isoform Inhibitors Based on Pyrrol-2-one Moiety. JOURNAL OF MEDICINAL CHEMISTRY, vol. 67, pp. 3018-3038, ISSN:0022-2623 DOI

Angeli A.; Occhini A.; Renzi G.; Capperucci A.; Ferraroni M.; Tanini D.; Supuran C.T. (2024). Thia- and Seleno-Michael Reactions for the Synthesis of Carbonic Anhydrases Inhibitors. CHEMMEDCHEM, pp. 0-0, ISSN:1860-7187 DOI Accesso ONLINE all'editore

Andrea Angeli; Marta Ferraroni; Carlotta Granchi; Filippo Minutolo; Xiaozhuo Chen; Pratik Shriwas; Emilio Russo; Antonio Leo; Silvia Selleri; Fabrizio Carta; Claudiu T. Supuran (2023). First-in-Class Dual Targeting Compounds for the Management of Seizures in Glucose Transporter Type 1 Deficiency Syndrome. JOURNAL OF MEDICINAL CHEMISTRY, pp. 0-0, ISSN:0022-2623 DOI

Angeli A.; Ferraroni M.; Bonardi A.; Supuran C.T.; Nocentini A. (2023). Diversely N-substituted benzenesulfonamides dissimilarly bind to human carbonic anhydrases: crystallographic investigations of N-nitrosulfonamides. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 38, pp. 2178430-2178430, ISSN:1475-6366 DOI

Maria Giulia Davighi, Camilla Matassini, Andrea Goti, Marta Ferraroni, Andrea Angeli, Claudiu T. Supuran, Francesca Cardona (2023). Mono- and three-tailed sugar and iminosugar decorated benzenesulfonamide carbonic anhydrase inhibitors. ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 2023, pp. 1-13, ISSN:1477-0520 DOI Accesso ONLINE all'editore

Ferraroni M. (2023). Nonheme mono- and dioxygenases. Metalloenzymes: From Bench to Bedside , pp. 467-484 DOI

Eppinger E.; Stolz A.; Ferraroni M. (2023). Crystal structure of the monocupin ring-cleaving dioxygenase 5-nitrosalicylate 1,2-dioxygenase from Bradyrhizobium sp. ACTA CRYSTALLOGRAPHICA. SECTION D, STRUCTURAL BIOLOGY, vol. 79, pp. 632-640, ISSN:2059-7983 DOI

Gerace A.; Masini V.; Crocetti L.; Giovannoni M.P.; Ferraroni M. (2023). X-ray structural study of human neutrophil elastase inhibition with a series of azaindoles, azaindazoles and isoxazolones. JOURNAL OF MOLECULAR STRUCTURE, vol. 1274, pp. 134595-134601, ISSN:0022-2860 DOI

Tinivella, Annachiara; Nwachukwu, Jerome C; Angeli, Andrea; Foschi, Francesca; Benatti, Anna Laura; Pinzi, Luca; Izard, Tina; Ferraroni, Marta; Erumbi, Rangarajan; Christodoulou, Michael S; Passarella, Daniele; Supuran, Claudiu T; Nettles, Kendall W; Rastelli, Giulio (2023). Design, synthesis, biological evaluation and crystal structure determination of dual modulators of carbonic anhydrases and estrogen receptors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 246, pp. 115011-115011, ISSN:0223-5234 DOI

Denner T.C.; Angeli A.; Ferraroni M.; Supuran C.T.; Csuk R. (2023). Ureidobenzenesulfonamides as Selective Carbonic Anhydrase I, IX, and XII Inhibitors. MOLECULES, vol. 28, pp. 0-0, ISSN:1420-3049 DOI Accesso ONLINE all'editore

Angeli A.; Micheli L.; Carta F.; Ferraroni M.; Pirali T.; Fernandez Carvajal A.; Ferrer Montiel A.; Di Cesare Mannelli L.; Ghelardini C.; Supuran C.T. (2023). First-in-Class Dual Hybrid Carbonic Anhydrase Inhibitors and Transient Receptor Potential Vanilloid 1 Agonists Revert Oxaliplatin-Induced Neuropathy. JOURNAL OF MEDICINAL CHEMISTRY, vol. 66, pp. 1616-1633, ISSN:0022-2623 DOI

Ferraroni M; Angeli A; Carradori S; Supuran CT (2022). Inhibition of Schistosoma mansoni carbonic anhydrase by the antiparasitic drug clorsulon: X-ray crystallographic and in vitro studies. ACTA CRYSTALLOGRAPHICA. SECTION D, STRUCTURAL BIOLOGY, vol. 78, pp. 321-327, ISSN:2059-7983 DOI

Bazzicalupi, Carla; Bonardi, Alessandro; Biver, Tarita; Ferraroni, Marta; Papi, Francesco; Savastano, Matteo; Lombardi, Paolo; Gratteri, Paola (2022). Probing the Efficiency of 13-Pyridylalkyl Berberine Derivatives to Human Telomeric G-Quadruplexes Binding: Spectroscopic, Solid State and In Silico Analysis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, pp. 14061-14076, ISSN:1422-0067 DOI Accesso ONLINE all'editore

Angeli A.; Ferraroni M.; Capperucci A.; Tanini D.; Costantino G.; Supuran C.T. (2022). Selenocarbamates As a Prodrug-Based Approach to Carbonic Anhydrase Inhibition. CHEMMEDCHEM, vol. 17, pp. e2022000085-0, ISSN:1860-7179 DOI Accesso ONLINE all'editore

Sbravati D.; Bonardi A.; Bua S.; Angeli A.; Ferraroni M.; Nocentini A.; Casnati A.; Gratteri P.; Sansone F.; Supuran C.T. (2022). Calixarenes Incorporating Sulfonamide Moieties: Versatile Ligands for Carbonic Anhydrases Inhibition. CHEMISTRY-A EUROPEAN JOURNAL, vol. 28, pp. 1-8, ISSN:0947-6539 DOI Accesso ONLINE all'editore

Angeli A.; Ferraroni M.; Carta F.; Haberli C.; Keiser J.; Costantino G.; Supuran C.T. (2022). Development of Praziquantel sulphonamide derivatives as antischistosomal drugs. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 1479-1494, ISSN:1475-6366 DOI

Sharonova, Tatiana; Zhmurov, Petr; Kalinin, Stanislav; Nocentini, Alessio; Angeli, Andrea; Ferraroni, Marta; Korsakov, Mikhail; Supuran, Claudiu T; Krasavin, Mikhail (2022). Diversely substituted sulfamides for fragment-based drug discovery of carbonic anhydrase inhibitors: synthesis and inhibitory profile. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 857-865-865, ISSN:1475-6366 DOI

Tanini D.; Capperucci A.; Locuoco M.; Ferraroni M.; Costantino G.; Angeli A.; Supuran C.T. (2022). Benzoselenoates: A novel class of carbonic anhydrase inhibitors. BIOORGANIC CHEMISTRY, vol. 122, pp. 0-0, ISSN:0045-2068 DOI Accesso ONLINE all'editore

Debora Pratesi, Andrea Sodini, Camilla Matassini, Francesca Cardona, Andrea Angeli, Fabrizio Carta, Marta Ferraroni, Claudiu T. Supuran, Andrea Goti (2021). Synthesis of Azasugar–Sulfonamide conjugates and their Evaluation as Inhibitors of Carbonic Anhydrases: the Azasugar Approach to Selectivity. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2021, pp. 2604-2614, ISSN:1099-0690 DOI

Andrea Angeli; Marta Ferraroni; Akram A. Da’dara; Silvia Selleri; Mariana Pinteala; Fabrizio Carta; Patrick J. Skelly; Claudiu T. Supuran (2021). Structural Insights into Schistosoma mansoni Carbonic Anhydrase (SmCA) Inhibition by Selenoureido-Substituted Benzenesulfonamides. JOURNAL OF MEDICINAL CHEMISTRY, pp. 0-0, ISSN:0022-2623 DOI

Subbotina N.M.; Chernykh A.M.; Taranov A.I.; Shebanova A.D.; Moiseeva O.V.; Ferraroni M.; Kolomytseva M.P. (2021). Gentisate 1,2-dioxygenase from the gram-positive bacteria Rhodococcus opacus 1CP: Identical active sites vs. different substrate selectivities. BIOCHIMIE, vol. 180, pp. 90-103, ISSN:0300-9084 DOI Accesso ONLINE all'editore

Tanini D.; Carradori S.; Capperucci A.; Lupori L.; Zara S.; Ferraroni M.; Ghelardini C.; Mannelli L.D.C.; Micheli L.; Lucarini E.; Carta F.; Angeli A.; Supuran C.T. (2021). Chalcogenides-incorporating carbonic anhydrase inhibitors concomitantly reverted oxaliplatin-induced neuropathy and enhanced antiproliferative action. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 225, pp. 0-0, ISSN:0223-5234 DOI

Plyasova A.A.; Berrino E.; Khan I.I.; Veselovsky A.V.; Pokrovsky V.S.; Angeli A.; Ferraroni M.; Supuran C.T.; Pokrovskaya M.V.; Alexandrova S.S.; Gladilina Y.A.; Sokolov N.N.; Hilal A.; Carta F.; Zhdanov D.D. (2021). Mechanisms of the Antiproliferative and Antitumor Activity of Novel Telomerase-Carbonic Anhydrase Dual-Hybrid Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY, vol. 64, pp. 11432-11444, ISSN:0022-2623 DOI

Vannozzi G.; Vullo D.; Angeli A.; Ferraroni M.; Combs J.; Lomelino C.; Andring J.; Mckenna R.; Bartolucci G.; Pallecchi M.; Lucarini L.; Sgambellone S.; Masini E.; Carta F.; Supuran C.T. (2021). One-Pot Procedure for the Synthesis of Asymmetric Substituted Ureido Benzene Sulfonamides as Effective Inhibitors of Carbonic Anhydrase Enzymes. JOURNAL OF MEDICINAL CHEMISTRY, vol. 65, pp. 824-837, ISSN:0022-2623 DOI

Angeli, Andrea; Carta, Fabrizio; Donnini, Selene; Capperucci, Antonella; Ferraroni, Marta; Tanini, Damiano; Supuran, Claudiu T (2020). Selenolesterase enzyme activity of carbonic anhydrases. CHEMICAL COMMUNICATIONS, pp. 0-0, ISSN:1359-7345 DOI

Papi, Francesco; Bazzicalupi, Carla; Ferraroni, Marta; Ciolli, Giulia; Lombardi, Paolo; Khan, Asma Yasmeen; Kumar, Gopinatha Suresh; Gratteri, Paola (2020). Pyridine Derivative of the Natural Alkaloid Berberine as Human Telomeric G4-DNA Binder: A Solution and Solid-State Study. ACS MEDICINAL CHEMISTRY LETTERS, vol. 11, pp. 645-650, ISSN:1948-5875 DOI

Angeli A.; Ferraroni M.; Pinteala M.; Maier S.S.; Simionescu B.C.; Carta F.; Del Prete S.; Capasso C.; Supuran C.T. (2020). Crystal structure of a tetrameric type II β-carbonic anhydrase from the pathogenic bacterium burkholderia pseudomallei. MOLECULES, vol. 25, pp. 2269-2278, ISSN:1420-3049 DOI

Berrino E.; Angeli A.; Zhdanov D.D.; Kiryukhina A.P.; Milaneschi A.; De Luca A.; Bozdag M.; Carradori S.; Selleri S.; Bartolucci G.; Peat T.S.; Ferraroni M.; Supuran C.T.; Carta F. (2020). Azidothymidine "clicked" into 1,2,3-Triazoles: First Report on Carbonic Anhydrase-Telomerase Dual-Hybrid Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, pp. 7392-7409, ISSN:0022-2623 DOI

Da'dara A.A.; Angeli A.; Ferraroni M.; Supuran C.T.; Skelly P.J. (2019). Crystal structure and chemical inhibition of essential schistosome host-interactive virulence factor carbonic anhydrase SmCA. COMMUNICATIONS BIOLOGY, vol. 2, pp. 333-333, ISSN:2399-3642 DOI Accesso ONLINE all'editore

Angeli, Andrea; Tanini, Damiano; Nocentini, Alessio; Capperucci, Antonella; Ferraroni, Marta; Gratteri, Paola; Supuran, Claudiu T.* (2019). Selenols: a new class of carbonic anhydrase inhibitors. CHEMICAL COMMUNICATIONS, vol. 55, pp. 648-651, ISSN:1359-7345 DOI Accesso ONLINE all'editore

Niccolò Chiaramontea, Silvia Bua, Andrea Angeli, Marta Ferraroni, Ilaria Picchioni, Gianluca Bartolucci, Laura Braconi, Silvia Dei, Elisabetta Teodori, Claudiu T. Supuran, Maria Novella Romanelli (2019). Sulfonamides incorporating piperazine bioisosteres as potent human carbonic anhydrase I, II, IV and IX inhibitors. BIOORGANIC CHEMISTRY, vol. 91, pp. 1-11, ISSN:0045-2068 DOI

Angeli A.; Ferraroni M.; Nocentini A.; Selleri S.; Gratteri P.; Supuran C.T.; Carta F. (2019). Polypharmacology of epacadostat: A potent and selective inhibitor of the tumor associated carbonic anhydrases IX and XII. CHEMICAL COMMUNICATIONS, vol. 55, pp. 5720-5723, ISSN:1359-7345 DOI Accesso ONLINE all'editore

van Rixel V.H.S.; Busemann A.; Wissingh M.F.; Hopkins S.L.; Siewert B.; van de Griend C.; Siegler M.A.; Marzo T.; Papi F.; Ferraroni M.; Gratteri P.; Bazzicalupi C.; Messori L.; Bonnet S. (2019). Induction of a Four-Way Junction Structure in the DNA Palindromic Hexanucleotide 5'-d(CGTACG)-3' by a Mononuclear Platinum Complex. ANGEWANDTE CHEMIE, vol. 58, pp. 9378-9382, ISSN:1521-3773 DOI

Bozdag, Murat; Ferraroni, Marta; Ward, Carol; Carta, Fabrizio; Bua, Silvia; Angeli, Andrea; Langdon, Simon P; Kunkler, Ian H; Al-Tamimi, Abdul-Malek S; Supuran, Claudiu T (2019). Carbonic anhydrase inhibitors based on sorafenib scaffold: Design, synthesis, crystallographic investigation and effects on primary breast cancer cells. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 182, pp. 111600-111611, ISSN:1768-3254 DOI

Tanini, Damiano; Capperucci, Antonella; Ferraroni, Marta; Carta, Fabrizio; Angeli, Andrea; Supuran, Claudiu T. (2019). Direct and Straightforward access to substituted alkyl selenols as novel carbonic anhydrase inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, pp. 111811-111817, ISSN:0223-5234 DOI

Bozdag, Murat; Carta, Fabrizio; Ceruso, Mariangela; Ferraroni, Marta; McDonald, Paul C.; Dedhar, Shoukat; Supuran, Claudiu T.* (2018). Discovery of 4-Hydroxy-3-(3-(phenylureido)benzenesulfonamides as SLC-0111 Analogues for the Treatment of Hypoxic Tumors Overexpressing Carbonic Anhydrase IX. JOURNAL OF MEDICINAL CHEMISTRY, vol. 61, pp. 0-0, ISSN:0022-2623 DOI Accesso ONLINE all'editore

Guarra, Federica; Marzo, Tiziano; Ferraroni, Marta; Papi, Francesco; Bazzicalupi, Carla*; Gratteri, Paola; Pescitelli, Gennaro; Messori, Luigi; Biver, Tarita; Gabbiani, Chiara (2018). Interaction of a gold(i) dicarbene anticancer drug with human telomeric DNA G-quadruplex: solution and computationally aided X-ray diffraction analysis. DALTON TRANSACTIONS, vol. 47, pp. 16132-16138, ISSN:1477-9226 DOI Accesso ONLINE all'editore

Angeli, Andrea; Tanini, Damiano; Capperucci, Antonella; Malevolti, Gianni; Turco, Francesca; Ferraroni, Marta; Supuran, Claudiu T.* (2018). Synthesis of different thio-scaffolds bearing sulfonamide with subnanomolar carbonic anhydrase II and IX inhibitory properties and X-ray investigations for their inhibitory mechanism. BIOORGANIC CHEMISTRY, vol. 81, pp. 642-648, ISSN:0045-2068 DOI Accesso ONLINE all'editore

Ferraroni, Marta; Cornelio, Benedetta; Sapi, Janos; Supuran, Claudiu T.; Scozzafava, Andrea (2018). Sulfonamide carbonic anhydrase inhibitors: Zinc coordination and tail effects influence inhibitory efficacy and selectivity for different isoforms. INORGANICA CHIMICA ACTA, vol. 470, pp. 128-132, ISSN:0020-1693 DOI Accesso ONLINE all'editore

Angeli, Andrea; Trallori, Elena; Ferraroni, Marta; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Supuran, Claudiu T.* (2018). Discovery of new 2, 5-disubstituted 1,3-selenazoles as selective human carbonic anhydrase IX inhibitors with potent anti-tumor activity. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 157, pp. 1214-1222, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Ferraroni, Marta*; Gaspari, Roberto; Scozzafava, Andrea; Cavalli, Andrea; Supuran, Claudiu T. (2018). Dioxygen, an unexpected carbonic anhydrase ligand. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 33, pp. 999-1005, ISSN:1475-6366 DOI

Niccolò Chiaramonte, Silvia Bua, Marta Ferraroni, Alessio Nocentini, Alessandro Bonardi, Gian Luca Bartolucci, Maria Concetta Durante, Laura Lucarini, Donata Chiapponi, Silvia Dei, Dina Manetti, Elisabetta Teodori, Paola Gratteri, Emanuela Masini, Claudiu T. Supuran, Maria Novella Romanelli (2018). 2-Benzylpiperazine: a new scaffold for potent human Carbonic Anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 151, pp. 363-375, ISSN:1768-3254 DOI

Angeli, Andrea; Ferraroni, Marta; Supuran, Claudiu T.* (2018). Famotidine, an Antiulcer Agent, Strongly Inhibits Helicobacter pylori and Human Carbonic Anhydrases. ACS MEDICINAL CHEMISTRY LETTERS, vol. 9, pp. 1035-1038, ISSN:1948-5875 DOI Accesso ONLINE all'editore

Ferraroni, Marta; Lucarini, Laura; Masini, Emanuela; Korsakov, Mikhail; Scozzafava, Andrea; Supuran, Claudiu T.*; Krasavin, Mikhail (2017). 1,3-Oxazole-based selective picomolar inhibitors of cytosolic human carbonic anhydrase II alleviate ocular hypertension in rabbits: Potency is supported by X-ray crystallography of two leads. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 25, pp. 4560-4565, ISSN:0968-0896 DOI Accesso ONLINE all'editore

Papi, F.; Ferraroni, M.; Rigo, R.; Da Ros, S.; Bazzicalupi, C.; Sissi, C.; Gratteri, P. (2017). Role of the Benzodioxole Group in the Interactions between the Natural Alkaloids Chelerythrine and Coptisine and the Human Telomeric G-Quadruplex DNA. A Multiapproach Investigation. JOURNAL OF NATURAL PRODUCTS, vol. 80, pp. 3128-3135, ISSN:0163-3864 DOI Accesso ONLINE all'editore

Ferraroni, Marta; Da Vela, Stefano; Kolvenbach, Boris A.; Corvini, Philippe F.X.; Scozzafava, Andrea (2017). The crystal structures of native hydroquinone 1,2-dioxygenase from Sphingomonas sp. TTNP3 and of substrate and inhibitor complexes. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, vol. 1865, pp. 520-530, ISSN:1570-9639 DOI Accesso ONLINE all'editore

Marta Ferraroni; Adrie H. Westphal; Marco Borsari; Juan Antonio Tamayo-Ramos; Fabrizio Briganti; Leo H. de Graaff; Willem J. H. van Berkel (2017). Structure and function of Aspergillus niger laccase McoG. BIOCATALYSIS, vol. 1, pp. 1-16, ISSN:2353-1746 DOI Accesso ONLINE all'editore

Papi, Francesco; Bazzicalupi, Carla; Ferraroni, Marta; Massai, Lara; Bertrand, Benoit; Gratteri, Paola; Colangelo, Donato; Messori, Luigi (2017). [Au(9-methylcaffein-8-ylidene)2]+/DNA Tel23 System: Solution, Computational, and Biological Studies. CHEMISTRY-A EUROPEAN JOURNAL, vol. 23, pp. 13784-13791, ISSN:0947-6539 DOI Accesso ONLINE all'editore

Del Prete, Sonia; Vullo, Daniela; De Luca, Viviana; Carginale, Vincenzo; Ferraroni, Marta; Osman, Sameh M.; Alothman, Zeid; Supuran, Claudiu T.; Capasso, Clemente (2016). Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 24, pp. 1115-1120, ISSN:0968-0896 DOI Accesso ONLINE all'editore

Vullo, Daniela; Del Prete, Sonia; De Luca, Viviana; Carginale, Vincenzo; Ferraroni, Marta; Dedeoglu, Nurcan; Osman, Sameh M.; Alothman, Zeid; Capasso, Clemente; Supuran, Claudiu T. (2016). Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 26, pp. 1406-1410, ISSN:0960-894X DOI Accesso ONLINE all'editore

Ferraroni, Marta; Carta, Fabrizio; Scozzafava, Andrea; Supuran, Claudiu T. (2016). Thioxocoumarins Show an Alternative Carbonic Anhydrase Inhibition Mechanism Compared to Coumarins. JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, pp. 462-473, ISSN:0022-2623 DOI Accesso ONLINE all'editore

Cornelio, Benedetta; Laronze Cochard, Marie; Ceruso, Mariangela; Ferraroni, Marta; Rance, Graham A.; Carta, Fabrizio; Khlobystov, Andrei N.; Fontana, Antonella; Supuran, CLAUDIU TRANDAFIR; Sapi, Janos (2016). 4-Arylbenzenesulfonamides as Human Carbonic Anhydrase Inhibitors (hCAIs): Synthesis by Pd Nanocatalyst-Mediated Suzuki-Miyaura Reaction, Enzyme Inhibition, and X-ray Crystallographic Studies. JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, pp. 721-732, ISSN:0022-2623 DOI Accesso ONLINE all'editore

Nocentini, Alessio; Ferraroni, Marta; Carta, Fabrizio; Ceruso, Mariangela; Gratteri, Paola; Lanzi, Cecilia; Masini, Emanuela; Supuran, Claudiu T (2016). Benzenesulfonamides Incorporating Flexible Triazole Moieties Are Highly Effective Carbonic Anhydrase Inhibitors: Synthesis and Kinetic, Crystallographic, Computational, and Intraocular Pressure Lowering Investigations. JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, pp. 10692-10704, ISSN:0022-2623 DOI Accesso ONLINE all'editore

Ferraroni, Marta; Bazzicalupi, Carla; Papi, Francesco; Fiorillo, Gaetano; Guamán-Ortiz, Luis Miguel; Nocentini, Alessio; Scovassi, Anna Ivana; Lombardi, Paolo; Gratteri, Paola (2016). Solution and Solid-State Analysis of Binding of 13-Substituted Berberine Analogues to Human Telomeric G-quadruplexes. CHEMISTRY - AN ASIAN JOURNAL, vol. 11, pp. 1107-1115, ISSN:1861-4728 DOI Accesso ONLINE all'editore

Bazzicalupi, Carla; Ferraroni, Marta; Papi, Francesco; Massai, Lara; Bertrand, Benoît; Messori, Luigi; Gratteri, Paola; Casini, Angela (2016). Determinants for Tight and Selective Binding of a Medicinal Dicarbene Gold(I) Complex to a Telomeric DNA G-Quadruplex: a Joint ESI MS and XRD Investigation. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, vol. 55, pp. 4256-4259, ISSN:1433-7851 DOI

Carta, Fabrizio; Ferraroni, Marta; Scozzafava, Andrea; Supuran, Claudiu T (2016). Fluorescent sulfonamide carbonic anhydrase inhibitors incorporating 1,2,3-triazole moieties: Kinetic and X-ray crystallographic studies. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 24, pp. 104-12-112, ISSN:0968-0896 DOI

Marta, Ferraroni; Carla, Bazzicalupi; Francesco, Papi; Paola, Gratteri (2016). Double helices forming unusual binding motifs: the case of the natural alkaloids coptisine and chelerythrine. In: Ferraroni, M., Bazzicalupi, C., Papi, Gratteri. Double helices forming unusual binding motifs: the case of the natural alkaloids coptisine and chelerythrine, pp. 81-102, New York: Nova science publisher, ISBN:9781634855129.

Ferraroni, Marta; Del Prete, Sonia; Vullo, Daniela; Capasso, Clemente; Supuran, Claudiu T. (2015). Crystal structure and kinetic studies of a tetrameric type II β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae. ACTA CRYSTALLOGRAPHICA. SECTION D, BIOLOGICAL CRYSTALLOGRAPHY, vol. 71, pp. 2449-2456, ISSN:0907-4449 DOI Accesso ONLINE all'editore

Eppinger, Erik; Ferraroni, Marta; Bürger, Sibylle; Steimer, Lenz; Peng, Grace; Briganti, Fabrizio; Stolz, Andreas (2015). Function of different amino acid residues in the reaction mechanism of gentisate 1,2-dioxygenases deduced from the analysis of mutants of the salicylate 1,2-dioxygenase from Pseudaminobacter salicylatoxidans. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, vol. 1854, pp. 1425-1437, ISSN:1570-9639 DOI Accesso ONLINE all'editore

M. Bozdag;M. Ferraroni;E. Nuti;D. Vullo;A. Rossello;F. Carta;A. Scozzafava;C. T. Supuran (2014). Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 22, pp. 334-340, ISSN:0968-0896 DOI Accesso ONLINE all'editore

M. Ferraroni;A. Scozzafava;S. Ullah;T. Tron;A. Piscitelli;G. Sannia (2014). Crystallization and preliminary X-ray crystallographic analysis of the small subunit of the heterodimeric laccase POXA3b from Pleurotus ostreatus.. ACTA CRYSTALLOGRAPHICA. SECTION F, STRUCTURAL BIOLOGY COMMUNICATIONS, vol. 70, pp. 76-79, ISSN:2053-230X DOI Accesso ONLINE all'editore

Bozdag M.; Ferraroni M.; Nuti E.; Vullo D.; Rossello A.; Carta F.; Scozzafava A.; Supuran C.T. (2014). Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: Solution and X-ray crystallographic studies. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 22, pp. 334-340, ISSN:0968-0896 DOI

M. Bozdag;M. Ferraroni;F. Carta;D. Vullo;L. Lucarini;E. Orlandini;A. Rossello;E. Nuti;A. Scozzafava;E. Masini;C. T. Supuran (2014). Structural insights on carbonic anhydrase inhibitory action, isoform selectivity, and potency of sulfonamides and coumarins incorporating arylsulfonylureido groups.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 57, pp. 9152-9167, ISSN:0022-2623 DOI Accesso ONLINE all'editore

Marina Kolomytseva; Marta Ferraroni; Alexey Chernykh; Ludmila Golovleva; Andrea Scozzafava (2014). Structural basis for the substrate specificity and the absence of dehalogenation activity in 2-chloromuconate cycloisomerase from Rhodococcus opacus 1CP. BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1844, pp. 1541-1549, ISSN:0006-3002 DOI

M. Ferraroni;M. Kolomytseva;A. Scozzafava;L. Golovleva;F. Briganti (2013). X-ray structures of 4-chlorocatechol 1,2-dioxygenase adducts with substituted catechols: New perspectives in the molecular basis of intradiol ring cleaving dioxygenases specificity.. JOURNAL OF STRUCTURAL BIOLOGY, vol. 181, pp. 274-282, ISSN:1047-8477 DOI Accesso ONLINE all'editore

M. Ferraroni;M. Kolomytseva;L. A. Golovleva;A. Scozzafava (2013). X-ray crystallographic and molecular docking studies on a unique chloromuconolactone dehalogenase from Rhodococcus opacus 1CP.. JOURNAL OF STRUCTURAL BIOLOGY, vol. 182, pp. 44-50, ISSN:1047-8477 DOI Accesso ONLINE all'editore

M. Ferraroni;I. Matera;S. Bürger;S. Reichert;L. Steimer;A. Scozzafava;A. Stolz;F. Briganti (2013). The salicylate 1,2-dioxygenase as a model for a conventional gentisate 1,2-dioxygenase: crystal structures of the G106A mutant and its adducts with gentisate and salicylate.. THE FEBS JOURNAL, vol. 280, pp. 1643-1652, ISSN:1742-4658 DOI Accesso ONLINE all'editore

Carla Bazzicalupi; Marta Ferraroni; Anna Rita Bilia; Francesca Scheggi; Paola Gratteri (2013). The crystal structure of human telomeric DNA complexed with berberine: an interesting case of stacked ligand to G-tetrad ratio higher than 1:1. NUCLEIC ACIDS RESEARCH, vol. 41, pp. 632-638, ISSN:0305-1048 DOI

S. Da Vela; M. Ferraroni; B. Kolvenbach; E. Keller; P. Corvini; A. Scozzafava; F. Briganti (2012). Crystallization and preliminary X-ray crystallographic analysis of hydroquinone dioxygenase from Sphingomonas sp. TTNP3. ACTA CRYSTALLOGRAPHICA. SECTION F, STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, vol. F68, pp. 588-590, ISSN:1744-3091 DOI Accesso ONLINE all'editore

M. Ferraroni; I. Matera; L. Steimer; S. Bürger; A. Scozzafava; A. Stolz; F. Briganti (2012). Crystal structures of salicylate 1,2-dioxygenase-substrates adducts: A step towards the comprehension of the structural basis for substrate selection in class III ring cleaving dioxygenases. JOURNAL OF STRUCTURAL BIOLOGY, vol. 177, pp. 431-438, ISSN:1047-8477 DOI

M. Ferraroni; I. Matera; A. Chernykh; M. Kolomytseva; L. A. Golovleva; A. Scozzafava; F. Briganti (2012). Reaction Intermediates and Redox State Changes in a Blue Laccase from Steccherinum ochraceum observed by Crystallographic High/Low X-Ray Dose Experiments. JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 111, pp. 203-209, ISSN:0162-0134 DOI Accesso ONLINE all'editore

M. Ferraroni; L. Steimer; I. Matera; S. Bürger; A. Scozzafava; A. Stolz; F. Briganti (2012). The generation of a 1-hydroxy-2-naphthoate 1,2-dioxygenase by single point mutations of salicylate 1,2-dioxygenase – Rational design of mutants and the crystal structures of the A85H and W104Y variants. JOURNAL OF STRUCTURAL BIOLOGY, vol. 180, pp. 563-571, ISSN:1047-8477 DOI Accesso ONLINE all'editore

M.Ferraroni; C. Bazzicalupi; A.R. Bilia; P. Gratteri (2011). X-ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine in complex with double helix DNA d(CGTACG). CHEMICAL COMMUNICATIONS, vol. 47, pp. 4917-4919, ISSN:1359-7345 DOI Accesso ONLINE all'editore

I. Matera; M. Ferraroni; M. Kolomytseva; L. Golovleva; A. Scozzafava; F. Briganti (2010). Catechol 1,2-dioxygenase from the Gram-positive Rhodococcus opacus 1CP: Quantitative structure/activity relationship and the crystal structures of native enzyme and catechols adducts. JOURNAL OF STRUCTURAL BIOLOGY, vol. 170, pp. 548-564, ISSN:1047-8477

M. P. Kolomytseva; M. Ferraroni ; A.M. Chernykh; A. Scozzafava; F. Briganti; L.A. Golovleva (2010). Experimental and theoretical affinity studies of substituted phenols tochlorocatechol 1,2-dioxygenases: A step toward the comprehension ofinhibitor/substrate binding to intradiol dioxygenases. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, vol. 64, pp. 53-59, ISSN:1381-1177

F.Briganti; M.Ferraroni (2009). Hydroxyquinol 1,2-dioxygenase. In: A.Messerschmidt (Editor). Handbook of Metalloproteins, pp. 1-12, Chichester: John Wiley, ISBN:9780470028636. DOI

A. Chernykh; N.Myasoedova; M. Kolomytseva; M. Ferraroni; A. Scozzafava; F. Briganti; L. Golovleva (2008). Laccase isoforms with unusual properties from the basidiomycete Steccherinum ochraceum strain 1833. JOURNAL OF APPLIED MICROBIOLOGY, vol. 105, pp. 2065-2075, ISSN:1364-5072

Dei, Silvia; Bellucci, Cristina; Buccioni, M.; Ferraroni, Marta; Guandalini, Luca; Manetti, Dina; Marucci, G.; Matucci, Rosanna; Nesi, Marta; Romanelli, MARIA NOVELLA; Scapecchi, Serena; Teodori, Elisabetta (2008). Muscarinic antagonists with multiple stereocenters: synthesis, affinity profile and functional activity of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine sulfoxide derivatives. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, pp. 5490-5500, ISSN:0968-0896 DOI

Irene Matera; Marta Ferraroni; Sibylle Bürger; Andrea Scozzafava; Andreas Stolz; Fabrizio Briganti (2008). Salicylate 1,2-dioxygenase from Pseudaminobacter salicylatoxidans: crystal structure of a peculiar ring-cleaving dioxygenase.. JOURNAL OF MOLECULAR BIOLOGY, vol. 380, pp. 856-868, ISSN:0022-2836

I. Matera; A. Gullotto; S. Tilli; M. Ferraroni; A. Scozzafava; F. Briganti (2008). Crystal structure of the blue multicopper oxidase from the white-rot fungus Trametes trogii complexed with p-toluate. INORGANICA CHIMICA ACTA, vol. 361, pp. 4129-4137, ISSN:0020-1693

Dei, Silvia; Bellucci, Cristina; Buccioni, M.; Ferraroni, Marta; Guandalini, Luca; Manetti, Dina; Martini, Elisabetta; Marucci, G.; Matucci, Rosanna; Nesi, Marta; Romanelli, MARIA NOVELLA; Scapecchi, Serena; Teodori, Elisabetta (2007). SYNTHESIS, AFFINITY PROFILE AND FUNCTIONAL ACTIVITY OF MUSCARINIC ANTAGONISTS WITH A 1-METHYL-2-(2,2-ALKYLARYL-1,3-OXATHIOLAN-5-YL)PYRROLIDINE STRUCTURE. JOURNAL OF MEDICINAL CHEMISTRY, vol. 50, pp. 1409-1413, ISSN:0022-2623 DOI

Marta Ferraroni; Nina M Myasoedova; Vadim Schmatchenko; Alexey A Leontievsky; Ludmila A Golovleva; Andrea Scozzafava; Fabrizio Briganti (2007). Crystal structure of a blue laccase from Lentinus tigrinus: evidences for intermediates in the molecular oxygen reductive splitting by multicopper oxidases.. BMC STRUCTURAL BIOLOGY, vol. 7, pp. 60-60, ISSN:1472-6807

I. Matera; M. Ferraroni; S. Bürger; A. Stolz; F. Briganti (2006). Preliminary crystallographic analysis of salicylate 1,2-dioxygenase from Pseudaminobacter salicylatoxidans.. ACTA CRYSTALLOGRAPHICA. SECTION F, STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, vol. 62, pp. 553-555, ISSN:1744-3091

I Matera; M Ferraroni; S Bürger; A Stolz; F Briganti (2006). Crystal Structure Determination of a Salicylate 1,2-Dioxygenase from Pseudaminobacter salicylatoxidans. , in Hasylab Annual reports Accesso ONLINE all'editore

M. Ferraroni;M. P. Kolomytseva;I. P. Solyanikova;A. Scozzafava;L. A. Golovleva;F. Briganti (2006). Crystal structure of 3-chlorocatechol 1,2-dioxygenase key enzyme of a new modified ortho-pathway from the Gram-positive Rhodococcus opacus 1CP grown on 2-chlorophenol.. JOURNAL OF MOLECULAR BIOLOGY, vol. 360, pp. 788-799, ISSN:0022-2836 DOI Accesso ONLINE all'editore

S. SIMONE; E. CURCIO; G. DI PROFIO; M. FERRARONI; E. DRIOLI (2006). Polymeric hydrophobic membranes as a tool to control polymorphism and protein–ligand interactions. JOURNAL OF MEMBRANE SCIENCE, vol. 283(1), pp. 123-132, ISSN:0376-7388, Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598:

S. Dei; C. Bellucci; M. Buccioni; M. Ferraroni; L. Guandalini; D. Manetti; E. Martini; G. Marucci; R. Matucci; M. Nesi; M.N. Romanelli; S. Scapecchi; E. Teodori (2006). Antagonisti muscarinici a struttura 1,3-ossatiolano-2-pirrolidinica. In: XXII Congresso Nazionale della Società Chimica Italiana, Firenze, 10-15 Settembre 2006, Società Chimica Italiana, pp. 188-188.

S. DEI; R. BUDRIESI; P. SUDWAN; M. FERRARONI; A. CHIARINI; A. GARNIER-SUILLEROT; D. MANETTI; C. MARTELLI; S. SCAPECCHI; E. TEODORI (2005). Diphenylcyclohexylamine derivatives as new potent multidrug resistance (MDR) modulators. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 13, pp. 985-998, ISSN:0968-0896 DOI

M. FERRARONI; J. SEIFERT; V. TRAVKIN; M. THIEL; S. KASCHABEK; A. SCOZZAFAVA; L. GOLOVLEVA; M. SCHLOMANN; F. BRIGANTI (2005). Crystal structure of the hydroxyquinol 1,2-dioxygenase from Nocardioides simplex 3E, a key enzyme involved in polychlorinated aromatics biodegradation. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 280(22), pp. 21144-21154, ISSN:0021-9258, American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824:

M. Ferraroni;I. Duchi;N. M. Myasoedova;A. A. Leontievsky;L. A. Golovleva;A. Scozzafava;F. Briganti (2005). Crystallization and preliminary structure analysis of the blue laccase from the ligninolytic fungus Panus tigrinus.. ACTA CRYSTALLOGRAPHICA. SECTION F, STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, vol. 61, pp. 205-207, ISSN:1744-3091 DOI Accesso ONLINE all'editore

A Gullotto; I Matera; S Tilli; M Ferraroni; F Briganti (2005). Structure determination of a blue laccase from Trametes Trogii at 1.5 Å. , in Hasylab Annual reports Accesso ONLINE all'editore

M. FERRARONI; I. SOLYANIKOVA; M. KOLOMYTSEVA; A. SCOZZAFAVA; L. GOLOVLEVA; F. BRIGANTI (2004). Crystal structure of 4-chlorocatechol 1,2-dioxygenase from the chlorophenol-utilizing gram-positive Rhodococcus opacus 1CP. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279(26), pp. 27646-27655, ISSN:0021-9258, American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824:

S. Dei; R. Budriesi; P. Sudwan; M. Ferraroni; A. Chiarini; A. Garnier-Suillerot; D. Manetti; C. Martelli; S. Scapecchi; E. Teodori (2004). Nuovi modulatori della multidrug resistance (MDR) a struttura difenilcicloesilaminica. In: XVII Convegno Nazionale della Divisione di Chimica Farmaceutica della Società Chimica Italiana, Pisa, 6-10 Settembre 2004, Società Chimica Italiana, pp. 179-179.

RANDAZZO D.; FERRARONI M.; SCOZZAFAVA A.; GOLOVLEVA L.A.; F. BRIGANTI (2004). Biotransformation of Chloroaromatics: the Impact of Bioavailability and Substrate Specificity.. BIOINORGANIC CHEMISTRY AND APPLICATIONS, vol. 2, pp. 209-223, ISSN:1565-3633

Dei, Silvia; Bellucci, Cristina; Buccioni, M.; Ferraroni, Marta; Gualtieri, Fulvio; Guandalini, Luca; Manetti, Dina; Matucci, Rosanna; Romanelli, MARIA NOVELLA; Scapecchi, Serena; Teodori, Elisabetta (2003). Synthesis and Cholinergic Affinity of Diastereomeric and Enantiomeric Isomers of 1-Methyl-2-(2-methyl-1,3-dioxolan-4-yl)-pyrrolidine, 1-Methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine and of Their Iodomethylates. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11, pp. 3153-3164, ISSN:0968-0896 DOI

M. FERRARONI; M. Y. RUIZ TARIFA; A. SCOZZAFAVA; I. P. SOLYANIKOVA; M. P. KOLOMYTSEVA; L. GOLOVLEVA; F. BRIGANTI (2003). Preliminary Crystallographic Analysis of 3-Chlorocatechol 1,2-Dioxygenase of a New Modified Ortho-pathway from the Gram-Positive Rhodococcus opacus 1CP Grown on 2-Chlorophenol.. ACTA CRYSTALLOGRAPHICA. SECTION D, BIOLOGICAL CRYSTALLOGRAPHY, vol. 59, pp. 188-190, ISSN:0907-4449

M Ferraroni; MY Ruiz Tarifa; F Briganti; A Scozzafava; S Mangani; L Golovleva (2002). The crystal structure of a bacterial intradiol dioxygenases involved in the biodegradation of polychlorinated aromatic compounds. Accesso ONLINE all'editore

Silvia Dei; Cristina Bellucci; Michela Buccioni; Marta Ferraroni; Fulvio Gualtieri; Luca Guandalini; Dina Manetti; Rosanna Matucci; Maria Novella Romanelli; Serena Scapecchi; Katia Varani; Elisabetta Teodori (2002). Sintesi e affinità per i recettori colinergici degli stereoisomeri della 1-metil-2-(2-metil-1,3-diossolan-4-il)pirrolidina, della 1-metil-2-(2-metil-1,3-ossatiolan-5-il)pirrolidina e dei loro iodometilati. In: XVI convegno nazionale della Divisione di Chimica Farmaceutica, Società Chimica Italiana, Sorrento, 18-22 settembre 2002, Società Chimica Italiana Divisione di Chimica Farmaceutica, pp. 39-39.

M.FERRARONI; F.BRIGANTI; W.R.CHEGWIDDEN; C.T.SUPURAN; A.SCOZZAFAVA (2002). Crystal analysis of Aromatic sulfonamide binding to native and (Zn)2adduct to Human Carbonic Anhydrase I Michigan 1. INORGANICA CHIMICA ACTA, vol. 339, pp. 135-144, ISSN:0020-1693

FERRARONI M.; RUIZ TARIFA M.Y.; BRIGANTI F.; A. SCOZZAFAVA; MANGANI S.; SOLYANIKOVA I.P.; KOLOMYTSEVA M.P.; GOLOVLEVA L. (2002). 4-Chlorocatechol 1,2-dioxygenase fromthe chlorophenol-utilizing Gram-positive Rhodococcus opacus1CP: crystallization and preliminary crystallographic analysis.. ACTA CRYSTALLOGRAPHICA. SECTION D, BIOLOGICAL CRYSTALLOGRAPHY, vol. D58, pp. 1074-76, ISSN:0907-4449, Blackwell Munksgaard:PO Box 2148, Periodicals Department, DK-1016 Copenhagen K Denmark:011 45 33 755913, EMAIL: agentservices@oxon.blackwellpublishing.com, INTERNET: http://www.blackwellmunksgaard.com, Fax: 011 45 77 333377:

M. FERRARONI; S. TILLI; F. BRIGANTI; W. CHEGWIDDEN; C. SUPURAN; K. WIEBAUER; R. TASHIAN; A. SCOZZAFAVA (2002). Crystal structure of a zinc-activated variant of Human Carbonic Anhydrase I, CA I Michigan 1: evidence for a second zinc binding site involving arginine coordination. BIOCHEMISTRY, vol. 41, pp. 6237-6244, ISSN:0006-2960 DOI

FERRARONI M.; BRIGANTI F.; CHEGWIDDEN W.R.; SUPURAN C.T.; A. SCOZZAFAVA (2002). Crystal analysis of aromatic sulfonamide binding to native and (Zn)2 adduct of human carbonic anhydrase I Michigan 1.. INORGANICA CHIMICA ACTA, vol. 339, pp. 135-144, ISSN:0020-1693, Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598 Editore precedente:Prof Ugo Croatto Luogo pubbl. Padova Ultimo luogo pubblicazione: Lausanne.:

Maria Yolanda Ruiz Tarifa; Marta Ferraroni; Fabrizio Briganti; Andrea Scozzafava; Stefano Mangani; Ludmilla Golovleva (2001). Chlorocatechol 1, 2-dioxygenase from the Chlorophenol-utilizing Gram-positive Rhodococcus opacus 1CP: Crystallization and preliminary crystallographic analysis. , in Hasylab Annual reports Accesso ONLINE all'editore

Silvia Dei; Elisabetta Teodori; Cristina Bellucci; Fulvio Gualtieri; Luca Guandalini; Rosanna Matucci; Serena Scapecchi; Katia Varani; Marta Ferraroni (2001). (1,3-Dioxolane)- and (1,3-oxathiolane)-2-pyrrolidines: molecular hybrids with potential anti-Alzheimer activity. In: Hungarian-German-Italian-Polish Joint Meeting on Medicinal Chemistry, Budapest, 2-6 settembre 2001, Hungarian Chemical Society Organic and Medicinal Chemistry Division, pp. 72-72.

S. LI; S.J. KELLY; E. LAMANI; M. FERRARONI; M.J. JEDRZEJAS (2000). Structural basis of hyaluronan degradation by Streptococcus pneumoniae hyaluronate lyase. EMBO JOURNAL, vol. 19, pp. 1228-1240, ISSN:0261-4189 DOI

FERRARONI M.; RYPNIEWSKI W.; WILSON K.S.; VIEZZOLI M.S.; BANCI L.; I. BERTINI; MANGANI S. (1999). The Crystal structure of the Monomeric Human SOD Mutant F50E/G51E/E133Q at Atomic Resolution. The Enzyme mechanism Revisited. JOURNAL OF MOLECULAR BIOLOGY, vol. 288, pp. 413-426, ISSN:0022-2836

M. FERRARONI; W. RYPNIEWSKI; B. BRUNI; P. ORIOLI; S. MANGANI (1998). Crystallographic Determination of Reduced Bovine Superoxide-Dismutase at pH-5.0 and of Anion-Binding to its Active-Site. JBIC, vol. 3(4), pp. 411-422, ISSN:0949-8257 DOI

S. Mangani; M. Ferraroni (1997). Anion Recognition by Proteins. In: Bianchi, A.; Bowman-James, K.; García-España, E.. Supramolecular chemistry of anions, pp. 63-78, New York: WILEY-VCH.

BRUNI B; M. FERRARONI; ORIOLI P; SPERONI G (1996). A BIOLOGICALLY ACTIVE GOLD COMPLEX: TRICHLORO[(2-PYRIDYL) METHANOL-N]GOLD(III). ACTA CRYSTALLOGRAPHICA. SECTION C, CRYSTAL STRUCTURE COMMUNICATIONS, vol. 52, pp. 1423-1424, ISSN:0108-2701

S. Mangani; B. Bruni; P. Orioli; M. Ferraroni; W. Rypniewski; K.S. Wilson (1995). Cristallographic studies of reduced Cu(I)-Zn(II) bovine superoxide dismutase and its adducts with small inorganic anions. JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 59, pp. 377-377, ISSN:0162-0134 DOI Accesso ONLINE all'editore

S. MANGANI; M. FERRARONI; P. ORIOLI (1994). Interaction of Carboxypeptidase A with Anions: Crystal Structure of the Complex with the HPO42- Anion. INORGANIC CHEMISTRY, vol. 33, pp. 3421-3423, ISSN:0020-1669

Marta FERRARONI

Biography

Marta Ferraroni was born in Florence in 1965. She graduated with a degree in Chemistry in 1992 at the University of Florence (Italy) under the supervision of Prof. Pierluigi Orioli. In 1996 she obtained the PhD in Chemical Science at the University of Florence. She worked in the group of Prof. K. Wilson at EMBL, DESY, Hamburg, Germany and at the Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham, Birmingham, AL (Alabama, USA). She then returned to Florence where she works at the Deparment of Chemistry of the University of Florence as Associate Professor.

Marta FERRARONI

Curriculum

Education Degree in Chemistry - 1992 - University of Florence -dissertation title: “Anions interaction with Carboxypeptidase A: a crystallographic study”. Supervisor, Prof. Pierluigi Orioli; 1996 - PhD in Chemistry, University of Florence, dissertation title : “Application of high resolution x-ray crystallography to a meccanicistic study on Cu, Zn Superoxide dismutase”. Supervisor, Prof. Stefano Mangani. 1995 - 1996 - Research activity in the group of Prof. K. Wilson at EMBL, DESY, Hamburg, Germany. 1998-1999 - Post Doctoral Fellow, Center for Structural Biology, University of Alabama at Birmingham, Birmingham, USA. Academics Qualifications: Associate Professor - Disciplinary Scientific Field : (03/B1) - Faculty of Pharmacy, University of Florence. Didactic Activity M.F. has been Professor for General and Inorganic Chemistry in the Degree course in Scientific drug information, Faculty of Pharmacy, University of Florence. M.F. has been and is teaching assistant in the course of General and Inorganic Chemistry, Degree course in Pharmacy, Faculty of Pharmacy, University of Florence. M.F. thought a module in the course of Protein Structure, Degree course in Biotechnology, University of Florence. Currently M.F. is Professor of General and Inorganic Chemistry in the Degree course in Primary Educational Sciences, School of Humanistic and Educational Studies, University of Florence. Scientific production M.F. is co-author of more than 100 scientific articles published on international peer-reviewed journals and of 5 chapter of books edited by international publishing companies.

Marta FERRARONI

Interest

The research activity of Prof. Marta Ferraroni is concentrated in the field of Bioinorganic Chemistry and its primary aim is the comprehension of the structure-activity relationships of metalloenzymes involved in relevant processes. Her principal scientific activity is focused on the study of enzymes, involved in the biodegradation of aromatic compounds, such Laccases and Ring-cleaving Dioxygenases, and of Carbonic anhydrases. Another field of interest is represented by the study of drugs – DNA (duplex and quadruplex) interactions.