Martina CACCIARINI

Ruolo attuale:: Professore Associato
SSD:: CHEM-05/A - Chimica organica
Afferenza organizzativa:: Dipartimento di Chimica 'Ugo Schiff' - DICUS

Recapiti

	0554573544
	martina.cacciarini(AT)unifi.it

Martina CACCIARINI

Orario di ricevimento (aggiornato al 29/08/2022)

Preferibilmente tramite MEET. Tutti i giorni, previo appuntamento preso per email.

Martina CACCIARINI

Biografia

Martina Cacciarini graduated in Chemistry (magna cum laude) at the University of Florence, Italy, where she received her PhD in Chemical Science in 2001, working on New Synthetic Methods: Taurine Analogues and Pyrrolizidine Alkaloid. After one year as junior researcher in Menarini Ricerche, in 2002 she became assistant professor at the University of Florence and started working on Synthetic Receptors for Molecular Recognition of Carbohydrates. In 2004, she was visiting researcher at ETH (Switzerland) to study Molecular Recognition of Steroids in the group of prof. F. Diederich. In 2009, she was visiting researcher at the Kemisk Institut of Copenhagen University working with prof. M. Bols and prof. Mogens B. Nielsen and she became interested in Molecular Switches. In 2013 and 2014 she moved to the Centre for Exploitation of Solar Energy of Copenhagen University and she was awarded a grant from Carlsbergfondet to study Photochromic Molecules for Energy Storage. Since then, she has established a strong collaboration with the Chemistry Department at the University of Copenhagen.

Since 2018, she is Associate Professor at the University of Florence.

Martina Cacciarini main scientific interests concern the development of stimuli-responsive smart systems with a broad area of applications, from solar energy storage, information encryption, molecular machines and sensors, to photopharmacology and bioapplications.

Born in 1973, she is married with two children (born in 2010 and 2012).

Martina CACCIARINI

Curriculum

Istruzione:

- 1998, Laurea in Chimica, 110/110 e lode (Dipartimento di Chimica Organica, Universitá di Firenze)

- 2001, PhD in Scienze Chimiche, Universitá di Firenze.

Esperienze lavorative:

- 2018: Professore Associato, Universitá di Firenze.

- Abilitazione Scientifica Nazionale a professore di II fascia - bando 2013

- 2002-2018: Ricercatore, Universitá di Firenze.

- 2002: Menarini-Ricerche, Firenze, Ricercatore nei laboratori di sintesi organica.

- 1998: Borsa di studio su “Synthesis of 5-a-reductase inhibitors” (Responsabile scientifico: Prof. A. Guarna, in collaborazione con Ares Services, Geneve, Switzerland).

Esperienze internazionali:

- 2004: Visiting scientist presso ETH Hönggerberg, Zürich, Switzerland (Molecular recognition of steroids by partially bridged resorcinarene cavitands - Prof. F. Diederich)

- 2009: Visiting researcher presso il Kemisk Institut, Universitá di Copenhagen (DK), “Synthesis and characterization of model systems for the GFP chromophore”, in collaborazione con Prof. M. B. Nielsen e Prof. M. Bols

- 2011: Visiting researcher presso il Kemisk Institut, Universitá di Copenhagen (DK),“Molecular switches” in collaborazione con Prof. M. B. Nielsen.

- 2014 e 2015: Visiting researcher presso il Center for Exploitation of Solar Energy, Universitá di Copenhagen (DK), “Dihydroazulene/vinylheptafulvene-based probes for thiols” in collaborazione con Prof. M. B. Nielsen.

- 2015: finanziamento Carlsbergfondet per il progetto "PHOTOCHROMIC MOLECULES FOR ENERGY STORAGE"

Attivitá Didattica frontale svolta presso l´Universitá di Firenze:

- AA 2002-2003: Chimica Organica I (4 CFU su 10 CFU, titolare: prof. P. Sarti-Fantoni), CdL in CTF (Facoltá di Farmacia)

- dall´AA 2003-2004 al AA 2006-2007: Chimica Organica (7 CFU), per CdL in Controllo di Qualitá nel settore industriale e farmaceutico (Facoltá di Farmacia)

- dall´AA 2007-2008 al AA 2010-2011: Chimica Organica (10 CFU), per CdL in Farmacia (Facoltá di Farmacia)

- dall´AA 2011-2012 al AA 2014-2015: Congedo di maternitá e congedi per studio all´estero.

- dall´AA 2015-2016: Chimica Organica, per Laurea triennale in Scienze Naturali (Scuola di SMFN)

- dall´AA 2017-2018: Spettroscopia NMR in Chimica Organica, per Laurea Magistrale in Scienze Chimiche (Scuola di SMFN)

- dall´AA 2017-2018: Chimica Organica, per Laurea triennale in Scienze Faunistiche (Scuola di Agraria)

- dall´AA 2018-2019: Metodi di indagine spettroscopica in Chimica Organica, per Laurea Magistrale in Scienze Chimiche (Scuola di SMFN)

Martina CACCIARINI

Interessi

- Sintesi e nuove applicazioni di interruttori molecolari di seconda generazione e di molecole fotocromatiche "ibride" a risposta multipla e selettiva (dihydroazulene/vinylheptafulvene, norbornadiene/quadricyclane, E/Z azobenzenes, spiropyran/merocyanine).

- Studio della reattivitá del sistema dihydroazulene/vinylheptafulvene per modularne le caratteristiche chimico-fisiche: da sistemi per immagazzinare l´energia solare, a interruttori a risposta ultra-rapida e a dispositivi per immagazzinamento dati.

- Sviluppo di sistemi reversibili e sensibili a stimoli esterni, come luce e pH, per il controllo spazio temporale di interazioni biomolecolari (es recettore/unitá biologicamente attiva).

Gli studenti interessati a sviluppare la propria tesi di laurea presso (o in collaborazione con) l´Universitá di Copenaghen (DANIMARCA), possono contattarmi per maggiori dettagli sulle tematiche di ricerca disponibili e attualmente in corso.

Martina CACCIARINI

Note

Gli studenti interessati a sviluppare la propria tesi di laurea presso (o in collaborazione con) l´Universitá di Copenaghen (DANIMARCA), possono contattarmi per maggiori dettagli sulle tematiche di ricerca attive e in collaborazione con il prof. Mogens B. Nielsen e il Prof. Michael Pittelkow.

Martina CACCIARINI

Pubblicazioni

Legenda

Contributo su rivista |

Articolo su libro |

Libro |

Contributo in atti di convegno (proceeding) |

Brevetto |

Curatela | Altro

Altro |

Tesi di Dottorato

S. K. Vegge, J. N. Lienert, M. E. Krogh, S. G. Stenspil, M. Dowds, J. K. S. Hansen, C. Warming, C. von Aufschnaiter, V. B. Roug Pedersen, J. Wachtveitl, M. Cacciarini,* M. B. Nielsen (2025). Multistate Dihydroazulene-Spiropyran Dyads: Path-Dependent Switchings and Refinement of the “Meta-rule” of Photoactivity. CHEMISTRY-A EUROPEAN JOURNAL, pp. 1-12, ISSN:0947-6539 DOI

Maria Giulia Davighi, Camilla Matassini, Francesca Clemente, Paolo Paoli, Amelia Morrone, Martina Cacciarini, Andrea Goti, Francesca Cardona (2024). pH-Responsive Trihydroxylated Piperidines Rescue The Glucocerebrosidase Activity in Human Fibroblasts Bearing The Neuronopathic Gaucher-Related L444P/L444P Mutations in GBA1 Gene. CHEMBIOCHEM, pp. 1-13, ISSN:1439-7633 DOI Accesso ONLINE all'editore

Maria Giulia Davighi, Francesca Clemente, Emilie Sperling Andreasen, Mogens Brøndsted Nielsen, Camilla Matassini, Andrea Goti, Amelia Morrone, Paolo Paoli, Francesca Cardona, Martina Cacciarini (2024). Iminosugar-Dihydroazulenes as Mutant L444P Glucocerebrosidase Enhancers. CHEMISTRY & BIODIVERSITY, pp. 1-7, ISSN:1612-1880 DOI

Francesca Clemente, Maria Giulia Davighi, Camilla Matassini, Francesca Cardona, Andrea Goti, Amelia Morrone, Paolo Paoli, Tomás Tejero, Pedro Merino, Martina Cacciarini (2023). Light-Triggered Control of Glucocerebrosidase Inhibitors: Towards Photoswitchable Pharmacological Chaperones. CHEMISTRY, vol. 29, pp. 1-12, ISSN:1521-3765 DOI

Oliver Christensen, Lauge E. Nielsen, Jes Johansen, Karin Holk, Jonas Udmark, Mogens Brøndsted Nielsen, Martina Cacciarini,* Kurt V. Mikkelsen* (2022). DFT Study of Carbamoyl-substituted Dihydroazulene / Vinylheptafulvene Derivatives and Solvent Effects. JOURNAL OF PHYSICAL CHEMISTRY. C, pp. 4815-4825, ISSN:1932-7447 DOI

Mathias Dowds, Stine G. Stenspil, João H. de Souza, Bo W. Laursen, Martina Cacciarini,* Mogens Brøndsted Nielsen* (2022). Orthogonal- and Path-dependent Photo/Acidoswitching in an Eight-state Dihydroazulene-Spiropyran Dyad. CHEMPHOTOCHEM, vol. e202200152, pp. 1-8, ISSN:2367-0932 DOI

Christina Schøttler, Siri Krogh Vegge, Martina Cacciarini,* and Mogens Brøndsted Nielsen* (2022). Long-Term Energy Storage Systems Based on the Dihydroazulene/Vinylheptafulvene Photo-/Thermoswitch. CHEMPHOTOCHEM, pp. 1-6, ISSN:2367-0932 DOI

Maria Giulia Davighi, Francesca Clemente, Camilla Matassini, Francesca Cardona, Mogens Brøndsted Nielsen, Andrea Goti, Amelia Morrone, Paolo Paoli, Martina Cacciarini (2022). Photoswitchable inhibitors of human β-glucocerebrosidase. ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 20, pp. 1637-1641, ISSN:1477-0539 DOI Accesso ONLINE all'editore

Martina Cacciarini; Mogens Brøndsted Nielsen (2022). Dihydroazulene/Vinylheptafulvene (DHA/VHF) and Molecular Electronics. In: Zbigniew L. Pianowski, Ben L. Feringa. Molecular Photoswitches: Chemistry, Properties, and Applications, Volume 1, pp. 379-400 Zbigniew L. Pianowski, ISBN:9783527351046. DOI

Jianyu Zhang, Hanchen Shen, Xinyue Liu, Xueqin Yang, Søren Lindbæk Broman, Haoran Wang, Qiyao Li, Jacky W. Y. Lam, Haoke Zhang, Martina Cacciarini, Mogens Brøndsted Nielsen, Ben Zhong Tang (2022). A Dihydroazulene-Based Photofluorochromic AIE System for Rewritable 4D Information Encryption. ANGEWANDTE CHEMIE, pp. 1-9, ISSN:1521-3773 DOI Accesso ONLINE all'editore

Alvis Mengots, Andreas Erbs Hillers-Bendtsen, Sandra Doria, Frederik Ørsted Kjeldal, Nicolai Machholdt Høyer, Anne Ugleholdt Petersen, Kurt V. Mikkelsen, Mariangela Di Donato, Martina Cacciarini, and Mogens Brøndsted Nielsen (2021). Dihydroazulene-Azobenzene-Dihydroazulene Triad Photoswitches. CHEMISTRY, vol. 27, pp. 12437-12446, ISSN:1521-3765

Max D. J. Waters, Wenpeng Du, Andres Moreno Carrascosa, Brian Stankus, Martina Cacciarini, Peter M. Weber, and Theis I. Sølling (2021). Transient Symmetry Controls Photo Dynamics near Conical Intersections. THE JOURNAL OF PHYSICAL CHEMISTRY LETTERS, vol. 12, pp. 9220-9225, ISSN:1948-7185

Anna Ranzenigo, Franca M. Cordero, Martina Cacciarini,* and Mogens Brøndsted Nielsen (2021). ortho-Substituted 2-Phenyldihydroazulene Photoswitches: Enhancing the Lifetime of the Photoisomer by ortho-Aryl Interactions. MOLECULES, vol. 26, pp. 6462-6474, ISSN:1420-3049 DOI

Zhihang Wang, Henry Moïse, Martina Cacciarini, Mogens Brøndsted Nielsen, Masa-aki Morikawa, Nobuo Kimizuka, Kasper Moth-Poulsen (2021). Liquid-Based Multijunction Molecular Solar Thermal Energy Collection Device. ADVANCED SCIENCE, pp. 1-6, ISSN:2198-3844 DOI

Anne U. Petersen, Jonathan K. Solberg Hansen, Emilie S. Andreasen, Søren P. Christensen, A. Tolstrup, Anders B. Skov, A. Vlasceanu, M. Cacciarini*, M. Brøndsted Nielsen* (2020). Multi-Photochromic Molecules Based on Dihydroazulene Units. CHEMISTRY, vol. 26, pp. 13419-13428, ISSN:1521-3765 DOI

Mogens Brøndsted Nielsen,* Nicolai Ree,a Kurt V. Mikkelsen,* Martina Cacciarini* (2020). Tuning the dihydroazulene - vinylheptafulvene couple for storage of solar energy. RUSSIAN CHEMICAL REVIEWS, vol. 89, pp. 573-586, ISSN:0036-021X DOI

Martina Cacciarini*; Mogens B. Nielsen (2019). Recent Development of Dihydroazulene-based Molecular Switches. In: 14th International Symposium on Macrocyclic and Supramolecular Chemistry, Lecce, Italy, June 2-6, 2019, ISMSC2019, pp. P55-P55.

Benjamin N. Frandsen; Anders B. Skov; Martina Cacciarini; Mogens Brøndsted Nielsen; Henrik G. Kjaergaard (2019). Cover Feature: Computational and Experimental Evidence of Two Competing Thermal Electrocyclization Pathways for Vinylheptafulvene (Chem. Asian J. 8/2019).

Benjamin Normann Frandsen, Anders Bo Skov, Martina Cacciarini, Mogens Brøndsted Nielsen, Henrik Kjaergaard (2019). Computational and experimental evidence of two competing thermal electrocyclization pathways for vinylheptafulvene. CHEMISTRY - AN ASIAN JOURNAL, vol. 14, pp. 1111-1116, ISSN:1861-4728 DOI

Dianna Andersen, Martin Drøhse Kilde, Anders Kadziola, Martina Cacciarini*, Mogens Brøndsted Nielsen* (2018). Functionalization at C1 of the Dihydroazulene/Vinylheptafulvene Photo‐/Thermoswitch – Establishing Structure‐Property Relationship. HELVETICA CHIMICA ACTA, vol. 101, pp. 0-0, ISSN:0018-019X DOI Accesso ONLINE all'editore

Alexandru Vlasceanu, Martina Cacciarini,* Mogens Brøndsted Nielsen* (2018). Photo/thermochromic macrocycles based on dihydroazulenes, dithienylethenes, and spiropyrans. TETRAHEDRON, vol. 74, pp. 6635-6646, ISSN:0040-4020 DOI

Martina Cacciarini* ; Mogens B. Nielsen (2018). Systematic investigation of the structure-properties relationship of the DHA/VHF photochromic system. In: 3rd International Caparica Conference on Chromogenic and Emissive Materials, IC3EM2018, pp. O30A-O30A.

Torres-Pierna Héctor; Roscini Claudio; Alexandru Vlasceanu; Broman Søren L.; Jevric Martyn; Cacciarini Martina; Mogens Brøndsted Nielsen (2017). Photochromism of dihydroazulene-based polymeric thin films. DYES AND PIGMENTS, pp. 359-364, ISSN:0143-7208 DOI

Martina, Cacciarini; Alexandru, Vlasceanu; Martyn, Jevric; Mogens, Brøndsted Nielsen (2017). An effective trigger for energy release of vinylheptafulvene-based solar heat batteries. CHEMICAL COMMUNICATIONS, pp. 5874-5877, ISSN:1359-7345 DOI

Cacciarini, Martina;* Jevric, Martyn; Elm, Jonas; Petersen, Anne U.; Mikkelsen, Kurt V.; Nielsen, Mogens Brøndsted (2016). Fine-tuning the lifetimes and energy storage capacities of meta-stable vinylheptafulvenes via substitution at the vinyl position. RSC ADVANCES, pp. 49003-49010, ISSN:2046-2069 DOI

Skov, Anders B.; Broman, Søren Lindbæk; Gertsen, Anders S.; Elm, Jonas; Jevric, Martyn; Cacciarini, Martina; Kadziola, Anders; Mikkelsen, Kurt V.; Nielsen, Mogens Brøndsted (2016). Aromaticity-Controlled Energy Storage Capacity of the Dihydroazulene-Vinylheptafulvene Photochromic System. CHEMISTRY-A EUROPEAN JOURNAL, vol. 22, pp. 14567-14577, ISSN:0947-6539

Martina Cacciarini; Martyn Jevric; Mogens Brønsted Nielsen (2016). Monocyano-monosubstituted dihydroazulenes: from energy storage to fast-responsive materials. In: 2nd International Caparica Conference on Chromogenic and Emissive Materials, IC3EM2016, pp. O10A-O10A, ISBN:978-989-99639-0-0

Vlasceanu, Alexandru; Broman, Søren L.; Hansen, Anne S.; Skov, Anders B.; Cacciarini, Martina; Kadziola, Anders; Kjaergaard, Henrik G.; Mikkelsen, Kurt V.; Nielsen, Mogens Brøndsted (2016). Solar-Thermal Energy Storage in a Photochromic Macrocycle. CHEMISTRY-A EUROPEAN JOURNAL, pp. 10796-10800, ISSN:0947-6539 DOI

Martina Cacciarini; Anders B. Skov; Martyn Jevric; Anne S. Hansen; Jonas Elm; Henrik G. Kjaergaard; Kurt V. Mikkelsen; and Mogens Brøndsted Nielsen (2015). Towards Solar Energy Storage in the Photochromic Dihydroazulene-Vinylheptafulvene System. CHEMISTRY-A EUROPEAN JOURNAL, vol. 21, pp. 7454-7461, ISSN:0947-6539 DOI

Cacciarini, Martina; Larsen, Mie Højer; Nielsen, Mogens Brøndsted (2015). 1-Phosphorus-Functionalized Alk-1-ynes (Update 2015, Vol. 24). In: Martina Cacciarini, Mie Højer Larsen, Mogens Brøndsted Nielsen. Science of Synthesis – Knowledge Updates 2015/2, pp. 301-314 R. A. Aitken, M. Brøndsted Nielsen, J. Drabowicz, J. J. Li, B. J. Plietker, T. Wirth, ISBN:978-3-13-198461-6.

Larsen, Mie Højer; Cacciarini, Martina; Nielsen, Mogens Brøndsted (2015). 1-(Organooxy)alk-1-ynes and 1-(Heterooxy)alk-1-ynes (Update 2015, Vol. 24). In: Mie Højer Larsen, Martina Cacciarini, Mogens Brøndsted Nielsen. Science of Synthesis – Knowledge Updates 2015/2, pp. 243-258 R. A. Aitken, M. Brøndsted Nielsen, J. Drabowicz, J. J. Li, B. J. Plietker, T. Wirth, ISBN:978-3-13-198461-6.

Martina Cacciarini*, Søren Lindbæk Broman, Mogens Brøndsted Nielsen* (2014). Synthetic protocols for the key functionalizations of the photochromic dihydroazulene scaffold. ARKIVOC, vol. 2014, part (i), pp. 249-263, ISSN:1551-7012 DOI

Martina Cacciarini (2013). Recognition of Carbohydrates. In: Mogens Brøndsted Nielsen. Organic Synthesis and Molecular Engineering, pp. 284-304, John Wiley & Sons, Inc., Hoboken, NJ, USA: Mogens Brøndsted Nielsen, ISBN:978-1-118-15092-4. DOI

M. Cacciarini;* M. B. Nielsen; E. M. de Castro; L. Marinescu; M. Bols (2012). <beta>-Cyclodextrin as a mimetic of the natural GFP-chromophore environment. TETRAHEDRON LETTERS, vol. 53, pp. 973-976, ISSN:0040-4039 DOI

Martina Cacciarini;* Eduardo A. Della Pia; Mogens B. Nielsen (2012). Colorimetric Probe for the Detection of Thiols: The Dihydroazulene/ Vinylheptafulvene System. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, pp. 6064-6069, ISSN:1099-0690 DOI

V. Mazzanti; M. Cacciarini; S. L. Broman; C. R. Parker; M. Schau-Magnussen; A. D. Bond, M. B. Nielsen (2012). On the Bromination of the Dihydroazulene / Vinylheptafulvene Photo- / Thermoswitch. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, vol. 8, pp. 958-966, ISSN:1860-5397 DOI

M. Cacciarini; C. Nativi; M. Norcini; S. Staderini; O. Francesconi; S. Roelens (2011). Pyrrolic tripodal receptors for carbohydrates. Role of functional groups and binding geometry on carbohydrate recognition. ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 9, pp. 1085-1091, ISSN:1477-0520 DOI

R. U. Kadam; M. Bergmann; M. Hurley; D. Garg; M. Cacciarini; M. A. Swiderska; C. Nativi; M. Sattler; A. R. Smith; P. Williams; M. Càmara; A. Stocker; T. Darbre; J. L. Reymond (2011). A glycopeptide dendrite inhibitor of the galactose-specific lectin LecA and of Pseudomonas Aeruginosa biofilm. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, vol. 50, pp. 10613-10635, ISSN:1433-7851 DOI

E.M.V. Johansson; S.A. Crusz; E. Kolomiets; L. Buts; R.U. Kadam; M. Cacciarini; K.-M. Bartels; S.P. Diggle; M. Cámara; P. Williams; R. Loris; C. Nativi; F. Rosenau; K.-E. Jaeger; T. Darbre; J.-L. Reymond (2008). Inhibition and Dispersion of Pseudomonas aeruginosa Biofilms by Glycopeptide Dendrimers Targeting the Fucose-Specific Lectin LecB. CHEMISTRY & BIOLOGY, vol. 15, pp. 1249-1257, ISSN:1074-5521 DOI

C. NATIVI; M. CACCIARINI; O. FRANCESCONI; A. VACCA; G. MONETI; A. IENCO; S. ROELENS (2007). Pyrrolic Tripodal Receptors Effectively Recognizing Monosaccharides. Affinity Assessment through a Generalized Binding Descriptor.. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 129, pp. 4377-4385, ISSN:0002-7863 DOI

M. CACCIARINI; S. MENICHETTI; C. NATIVI; B. RICHICHI (2007). The hetero Diels-Alder approach to carbohydrate-containing molecular scaffolding. CURRENT ORGANIC SYNTHESIS, vol. 4, pp. 47-57, ISSN:1570-1794 DOI

C. NATIVI; M. CACCIARINI; O. FRANCESCONI; G. MONETI; S. ROELENS (2007). A b-Mannoside-Selective Pyrrolic Tripodal Receptor. ORGANIC LETTERS, vol. 9, pp. 4685-4688, ISSN:1523-7060 DOI Accesso ONLINE all'editore

M. CACCIARINI; E. CORDIANO; C. NATIVI; S. ROELENS (2007). A tricatecholic receptor for carbohydrate recognition: synthesis and binding studies. JOURNAL OF ORGANIC CHEMISTRY, vol. 72, pp. 3933-3936, ISSN:0022-3263 DOI

V.A.AZOV; A.BEEBY; M.CACCIARINI; A.G.CHEETHAM; F.DIEDERICH; M.FREI; J.K.GIMZEWSKI; V.GRAMLICH; B.HECHT; B.JAUN; T.LATYCHEVSKAIA; A.LIEB; Y.LILL; F.MAROTTI; A.SCHLEGEL; R.R.SCHLITTLER; P.J.SKINNER; P.SEILER; Y.YAMAKOSHI (2006). Resorcin[4]arene cavitand-based molecular switches. ADVANCED FUNCTIONAL MATERIALS, vol. 16, pp. 147-156, ISSN:1616-301X DOI

M. CACCIARINI; V. A. AZOV; P. SEILER; H. KUNZER; F. DIEDERICH (2005). Selective steroid recognition by a partially bridged resorcin[4]arene cavitand. CHEMICAL COMMUNICATIONS, vol. 42, pp. 5269-5271, ISSN:1359-7345 DOI

A. VACCA; C. NATIVI; M. CACCIARINI; R. PERGOLI; S. ROELENS (2004). A New Tripodal Receptor for Molecular Recognition of Monosaccharides. A Paradigm for Assessing Glycoside Binding Affinities and Selectivities by 1H NMR Spectroscopy.. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 126, pp. 16456-16465, ISSN:0002-7863 DOI

F. VENTURI; C. VENTURI; F. LIGUORI; M. CACCIARINI; M. MONTALBANO; C. NATIVI (2004). A new scaffold for the stereoselective synthesis of a-O-linked glycopeptide mimetics. JOURNAL OF ORGANIC CHEMISTRY, vol. 69, pp. 6153-6155, ISSN:0022-3263 DOI

F. CARDONA; E. FAGGI; F. LIGUORI; M. CACCIARINI; A. GOTI (2003). Total syntheses of Hyacinthacine A2 and 7-Deoxycasuarine by cycloaddition to a carbohydrate derived nitrone. TETRAHEDRON LETTERS, vol. 44, pp. 2315-2318, ISSN:0040-4039 DOI

A. BARTOLOZZI; S. PACCIANI; C. BENVENUTI; M. CACCIARINI; F. LIGUORI; S. MENICHETTI; C. NATIVI (2003). Totally Stereoselective Synthesis of 1,3-Disaccharides through Diels-Alder Reactions. JOURNAL OF ORGANIC CHEMISTRY, vol. 68, pp. 8529-8533, ISSN:0022-3263 DOI

F. M. CORDERO; M. CACCIARINI; F. MACHETTI; F. DE SARLO (2002). Synthesis of Taurine Analogues, Part 2. Amino-Sulfonation of Alkenes by a Three Component Reaction. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2002, pp. 1407-1411, ISSN:1434-193X

A. BRANDI; F. PISANESCHI; F. CARDONA; M. CACCIARINI; F. CORDERO; A. GOTI (2002). LIQUID- AND SOLID-PHASE SYNTHESES OF NECINE BASES BY MEANS OF 1,3-DIPOLAR CYCLOADDITION REACTIONS. In: 23RD IUPAC INTERNATIONAL SYMPOSIUM ON THE CHEMISTRY OF NATURAL PRODUCTS, FIRENZE, IUPAC, vol. Libro Abstract, pp. 308-308.

A. Goti; M. Cacciarini; F. Cardona; F. M. Cordero; A. Brandi (2001). Total Synthesis of (–)-Rosmarinecine by Intramolecular Cycloaddition of (S)-Malic Acid Derived Pyrroline N-Oxide. ORGANIC LETTERS, vol. 3, pp. 1367-1369, ISSN:1523-7060 DOI

F. MACHETTI; M. CACCIARINI; F. CATRAMBONE; F. M. CORDERO; S. ROMOLI; F. DE SARLO; (2000). SYNTHESIS OF TAURINE ANALOGUES. PART 1: 2-AMINOSULFONIC ACIDS FROM ALKENE-SULFUR MONOCHLORIDE ADDUCTS. JOURNAL OF CHEMICAL RESEARCH. SYNOPSES, vol. 2000, pp. 120-121, ISSN:0308-2342

F. MACHETTI; M. CACCIARINI; F. CATRAMBONE; F. M. CORDERO; M. FROSINI; F. DE SARLO (2000). Synthesis of Taurine Analogues from Alkenes. In: Fabrizio Machetti, Martina Cacciarini, Ferdinando Catrambone, Franca Maria Cordero, Maria Frosini, Franceaco De Sarlo. ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY , pp. 399-401, New York: Plenum Press:Book Customer Service, 233 Spring Street:New York, NY 10013:(212)620-8471, (212)620-8000, EMAIL: info@plenum.com, INTERNET: http://www.plenum.com, Fax: (212)807-1047, ISBN:0-306-46447-0.

A. Goti; S. Cicchi; M. Cacciarini; F. Cardona; V. Fedi; A. Brandi (2000). Straightforward Access to Enantiomerically Pure Highly Functionalized Pyrrolizidines by Cycloaddition of Maleic Acid Esters to Pyrroline N-Oxides Derived from Tartaric, Malic and Aspartic Acids. Synthesis of (–)-Hastanecine, 7-epi-Croalbinecine and (–)-Croalbinecine. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, pp. 3633-3645, ISSN:1434-193X

M. CACCIARINI; F. CORDERO; C. FAGGI; A. GOTI (2000). Cycloaddition Reactions of C,N-Diphenylnitrone to Methylene-gamma-butyrolactones. MOLECULES, vol. 5, pp. 637-647, ISSN:1420-3049 DOI

A. Goti; M. Cacciarini; F. Cardona; A. Brandi (1999). A Convenient Access to (3S)-3-(Triisopropyl)oxy-1-pyrroline N-Oxides, a Useful Intermediate for Polyfunctionalized Enantiopure Indolizidine and Pyrrolizidine Synthesis. TETRAHEDRON LETTERS, vol. 40, pp. 2853-2856, ISSN:0040-4039 DOI

Martina CACCIARINI

Biography

Martina Cacciarini graduated in Chemistry (magna cum laude) at the University of Florence, Italy, where she received her PhD in Chemical Science in 2001, working on New Synthetic Methods: Taurine Analogues and Pyrrolizidine Alkaloid. After one year as junior researcher in Menarini Ricerche, in 2002 she became assistant professor at the University of Florence and started working on Synthetic Receptors for Molecular Recognition of Carbohydrates. In 2004, she was visiting researcher at ETH (Switzerland) to study Molecular Recognition of Steroids in the group of prof. F. Diederich. In 2009, she was visiting researcher at the Kemisk Institut of Copenhagen University working with prof. M. Bols and prof. Mogens B. Nielsen and she became interested in Molecular Switches. In 2013 and 2014 she moved to the Centre for Exploitation of Solar Energy of Copenhagen University and she was awarded a grant from Carlsbergfondet to study Photochromic Molecules for Energy Storage. Since then, she has established a strong collaboration with the Chemistry Department at the University of Copenhagen.

Since 2018, she is Associate Professor at the University of Florence.

Martina Cacciarini main scientific interests concern the development of stimuli-responsive smart systems with a broad area of applications, from solar energy storage, information encryption, molecular machines and sensors, to photopharmacology and bioapplications.

Born in 1973, she is married with two children (born in 2010 and 2012).

Martina CACCIARINI

Curriculum

Education:

- 1998, Laurea in Chemistry, summa cum laude (Department of Organic Chemistry, University of Firenze)

- 2001, PhD in Chemical Science (Department of Organic Chemistry, University of Firenze)

Present and past positions:

- 2018: Associate Professor, University of Firenze.

- 2013 Scientific National Habilitation to Associate Professor of Organic Chemistry of the Italian Universities.

- 2002-2018: Assistant Professor, University of Firenze.

- 2002: Menarini-Ricerche, Firenze, Researcher in the Organic Synthesis Laboratory.

- 1998: Research fellowship on “Synthesis of 5-a-reductase inhibitors” (Supervisor: Prof. A. Guarna, collaboration project with Ares Services, Geneve, Switzerland).

International experiences:

- 2004: Visiting scientist at ETH Hönggerberg, Zürich, Switzerland (Molecular recognition of steroids by partially bridged resorcinarene cavitands - Prof. F. Diederich)

- 2009: Visiting researcher at Kemisk Institut, University of Copenhagen, Denmark (Synthesis and characterization of model systems for the GFP chromophore, in collaboration with Prof. M. B. Nielsen and Prof. M. Bols)

- 2011: Visiting researcher at Kemisk Institut , University of Copenhagen, Denmark (“Molecular switches” in collaboration with Prof. M. B. Nielsen)

- 2014 and 2015: Visiting researcher at the Center for Exploitation of Solar Energy, University of Copenhagen, Denmark (“Dihydroazulene/vinylheptafulvene-based probes for thiols” in collaboration with Prof. M. B. Nielsen)

- 2015: Carlsbergfondet grant for "PHOTOCHROMIC MOLECULES FOR ENERGY STORAGE"

Teaching experience:

Since 2002, she has been responsible for teaching Organic Chemistry courses to Bachelor and Master degree students.

Since 2017, she has been teaching Advanced NMR spectroscopy for small organic molecules, in the Master degree in Chemistry.

Martina CACCIARINI

Interest

Molecular switches:

Synthesis and novel application of second generation molecular switches and hybrid multimode photochromic systems (dihydroazulene/vinylheptafulvene, norbornadiene/quadricyclane, E/Z azobenzenes, spiropyran/merocyanine).
Tuning the properties and the reactivity of the dihydroazulene/vinylheptafulvene (DHA/VHF) system to store energy from sun-light, to develop ultra-fast switches or data storage devices.
Development of stimuli responsive systems for pH or light-mediated spatio temporal control of biomolecular interactions.