Lunedì ore 8-9 presso aula oculistica piano 2 CTO (dopo la degenza oculistica). Preferibilmente con accordi email o contattare Segreteria Oculistica al n. 055  794 6975 (ore 8-14). 

See Curriculum Vitae

Gianni Virgili è Professore Ordinario di Oftalmologia presso l'Università degli Studi di Firenze ed AOU Careggi, dove è Direttore della Scuola di Specializzazione in Oftalmologia, Direttore dell'unità operativa SOD Ottica Fisiopatologica ed è stato Coordinatore del Centro di Educazione e Riabilitazione Visiva. È medico oculista specialista in retina medica dal 1992. E’ stato Clinical Professor of Ophthalmology al Centre for Public Health, Queen’s University Belfast, Honorary Consultant at Belfast Health and Social Care Trust (Northern Ireland, UK) dal 1 gennaio 2021 al 30 settembre 2022.

Ha conseguito un Master in Epidemiologia presso l'Università di Torino, Italia, nel 2005 e ha ricevuto un'ampia formazione in biostatistica e metodi per la ricerca clinica, in particolare in revisioni sistematiche e meta-analisi. In ruoli svolti per la Direzione Generale e Sanitaria della AOU Careggi e per la Regione Toscana ha anche potuto sviluppare competenze di management sanitario e rischio clinico, comprensive della conoscenza degli indicatori di performance e della struttura dei dati amministrativi ospedalieri in tutte le specialità mediche, anche a livello regionale, svolgendo attività nel Controllo di Gestione di un grande ospedale. Collabora con l'Agenzia Sanitaria Regionale della Toscana per studi di farmacoepidemiologia.

Gianni è un esperto nella conduzione di revisioni sistematiche di intervento, inclusi metodi complessi (studi non randomizzati, network meta-analisi) e revisioni di accuratezza di test diagnostici (DTA). Le sue principali aree di interesse comprendono ricerca primaria sulla diagnosi e il trattamento dei disturbi medici della retina, sulla funzione visiva e la riabilitazione dell'ipovisione; le sue competenze metodologiche gli hanno permesso di fornire supporto metodologico e statistico a ricercatori in diversi campi, tra cui neurologia, immunologia, allergologia, radiologia, medicina di laboratorio, anestesiologia e ortopedia. Ha inoltre pubblicato relazioni e studi utilizzando dati amministrativi elettronici, collaborando in particolare con la rete dei registri dei tumori EUROCARE e RARECARE e con l'Agenzia sanitaria regionale della Toscana.

Le revisioni Cochrane sono spesso citate nelle linee guida cliniche e 16 revisioni o update di cui è autore Gianni Virgili sono state citate in linee guida (da una a quattro ciascuna). Le revisioni Cochrane includono la preparazione di Summary of Findings Tables utilizzando il metodo GRADE, al fine di fornire una sintesi dei risultati della revisione, nonché un riepilogo per il pubblico (Plain Language Summary). Gianni ha maturato una vasta esperienza di autore ed editor nell'uso di GRADE in revisioni di interventi e diagnostiche, nonché in network meta-analisi. La sua competenza metodologica ha portato anche alla pubblicazione di 12 articoli sui metodi per condurre sintesi di evidenze, la maggior parte dei quali con autori internazionali.

Gianni è membro dell’editorial board della rivista Internal and Emergency Medicine (sezione HTA and Clinical Evidence, 2010), academic editore della rivista PLOS ONE (2015 in poi, 123 submission gestite fino ad oggi, inclusive di tematiche metodologiche e di salute pubblica) ed Executive Editor per le revisioni sistematiche dell'American Journal of Ophthalmology (dal 2016 in poi, 270 submission gestite, tra cui revisioni sistematiche e altri disegni di studio).

Pubblicazioni e indici bibliometrici:

• Autore di 313 pubblicazioni in Index Medicus su PubMed

• Indice H Scopus: 40; Scopus ID: 7006732630, con 326 titoli e 8455 citazioni

• Indice H di Google Scholar: 50, citazioni 12250; ORCID: 0000-0002-9960-2989

È membro di un progetto collaborativo internazionale gestito dal satellite statunitense di Cochrane Eyes and Vision (precedentemente presso Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, ora presso University of Colorado, Denver, Colorado), con l'obiettivo di supportare gli Associate Editors in riviste di oftalmologia e optometria che si dedicano al miglioramento della qualità della revisioni sistematiche (sovvenzione del National Eye Institute, National Institutes of Health).

È membro del Technical Working Group per la preparazione del WHO Package of Refractive Error Interventions e del WHO Package of Rehabilitation Interventions for Vision rehabilitation dell'OMS. In questo progetto, in qualità di editor di Cochrane Eyes and Vision, Gianni Virgili ha fornito supporto tecnico al progetto per quanto riguarda la selezione e l'utilizzo di revisioni sistematiche e linee guida cliniche

Gianni ha una vasta esperienza di insegnamento in corsi di laurea, corsi di laurea magistrale e dottorati di ricerca, incluso l’insegnamento della metodologia della ricerca e metodologia delle revisioni sistematiche. Ha inoltre contribuito alla formazione di diversi professionisti sanitari (infermieri, tecnici, medici, membri dei Comitati Etici) in materia di medicina basata sulle evidenze e metodologia delle revisioni sistematiche, inclusi operatori sanitari ospedalieri, in Italia e all'estero. Durante la sua recente esperienza alla Queen's University di Belfast, è stato facilitatore in corsi per piccoli gruppi di Case Based Learning, supervisor di studenti di medicina, co-supervisor di uno studente di dottorato, docente sulla metodologia della revisione sistematica al Master in Public and Global Health.

Pubblicazioni scientifiche  

Autore di 313 articoli in Index Medicus (available on PubMed).

https://pubmed.ncbi.nlm.nih.gov/?term=virgili+gianni ).

Autore di 325 articoli in SCOPUS https://www.scopus.com/authid/detail.uri?authorId=7006732630

Profilo Researchgate https://www.researchgate.net/profile/Gianni_Virgili/contributions?ev=prf_act

Di seguito pubblicazioni selezionate.

Cochrane reviews di interventi (standard)

1. van Nispen RM, Virgili G, Hoeben M, Langelaan M, Klevering J, Keunen JE, van Rens GH. Low vision rehabilitation for better quality of life in visually impaired adults. Cochrane Database Syst Rev. 2020 Jan 27;1:CD006543
2. Virgili G, Parravano M, Menchini F, Evans JR. Anti-vascular endothelial growth factor for diabetic macular oedema. Cochrane Database Syst Rev. 2014 Oct 24;(10):CD007419. doi: 10.1002/14651858.CD007419.pub4. Update in: Cochrane Database Syst Rev. 2017 Jun 22;6:CD007419. PMID: 25342124.
3. Parravano M, Menchini F, Virgili G. Antiangiogenic therapy with anti-vascular endothelial growth factor modalities for diabetic macular oedema. Cochrane Database Syst Rev. 2009 Oct 7;(4):CD007419. 
4. Rittiphairoj T, Mir TA, Li T, Virgili G. Intravitreal steroids for macular edema in diabetes. Cochrane Database Syst Rev. 2020 Nov 17;11(11):CD005656.
5. Virgili G, Michelessi M, Parodi MB, Bacherini D, Evans JR. Laser treatment of  drusen to prevent progression to advanced age-related macular degeneration. Cochrane Database Syst Rev. 2015 Oct  3;10:CD006537. doi: 10.1002/14651858.CD006537.pub3. Review. PubMed PMID: 26493180
6. Parravano M, Giansanti F, Eandi CM, Yap YC, Rizzo S, Virgili G. Vitrectomy for idiopathic macular hole. Cochrane Database Syst Rev. 2015 May 12;5:CD009080.
7. Jorge EC, Jorge EN, Botelho M, Farat JG, Virgili G, El Dib R. Monotherapy laser photocoagulation for diabetic macular oedema. Cochrane Database Syst Rev. 2018 Oct 15;10:CD010859.
8. Stuart AJ, Romano V, Virgili G, Shortt AJ. Descemet's membrane endothelial keratoplasty (DMEK) versus Descemet's stripping automated endothelial keratoplasty (DSAEK) for corneal endothelial failure. Cochrane Database Syst Rev. 2018 Jun 25;6:CD012097.
9. Li E, Donati S, Lindsley KB, Krzystolik MG, Virgili G. Treatment regimens for administration of anti-vascular endothelial growth factor agents for neovascular age-related macular degeneration. Cochrane Database Syst Rev. 2020 May5;5:CD012208.
10. Hu K, Shah A, Virgili G, Bunce C, Gazzard G. Ab interno trabecular bypass surgery with Trabectome for open-angle glaucoma. Cochrane Database Syst Rev. 2021 Feb 4;2(2):CD011693.
11. Sena DF, Kilian R, Liu SH, Rizzo S, Virgili G. Pneumatic retinopexy versus scleral buckle for repairing simple rhegmatogenous retinal detachments. Cochrane Database Syst Rev. 2021 Nov 11;11(11):CD008350.
12. Evans JR, Michelessi M, Virgili G. Laser photocoagulation for proliferative diabetic retinopathy. Cochrane Database Syst Rev. 2014 Nov 24;2014(11):CD011234
13. Sundaram V, Barsam A, Virgili G. Intravitreal low molecular weight heparin and 5-Fluorouracil for the prevention of proliferative vitreoretinopathy following retinal reattachment surgery. Cochrane Database Syst Rev. 2013 Jan 31;(1):CD006421. 
14. Parodi MB, Virgili G, Evans JR. Laser treatment of drusen to prevent progression to advanced age-related macular degeneration. Cochrane Database Syst Rev. 2009 Jul 8;(3):CD006537. doi: 10.1002/14651858.CD006537.pub2. Update in: Cochrane Database Syst Rev. 2015;10:CD006537. PMID: 19588397.
15. Virgili G, Michelessi M, Parodi MB, Bacherini D, Evans JR. Laser treatment of drusen to prevent progression to advanced age-related macular degeneration. Cochrane Database Syst Rev. 2015 Oct 23;10(10):CD006537.  UPDATE
16. Eandi CM, Giansanti F, Virgili G. Macular translocation for neovascular age-related macular degeneration. Cochrane Database Syst Rev. 2008 Oct 8;(4):CD006928. 
17. Virgili G, Bini A. Laser photocoagulation for neovascular age-related macular degeneration. Cochrane Database Syst Rev. 2007 Jul 18;(3):CD004763. 
18. Virgili G, Acosta R. Reading aids for adults with low vision. Cochrane Database Syst Rev. 2006 Oct 18;(4):CD003303. doi: 10.1002/14651858.CD003303.pub2
19. Virgili G, Acosta R, Grover LL, Bentley SA, Giacomelli G. Reading aids for adults with low vision. Cochrane Database Syst Rev. 2013 Oct 23;10(10):CD003303. UPDATE
20. Virgili G, Acosta R, Bentley SA, Giacomelli G, Allcock C, Evans JR. Reading aids for adults with low vision. Cochrane Database Syst Rev. 2018 Apr 17;4(4):CD003303. UPDATE

Cochrane reviews di interventi e di valutazioni economiche

Virgili G, Parravano M, Menchini F, Brunetti M. Antiangiogenic therapy with anti-vascular endothelial growth factor modalities for diabetic macular oedema. Cochrane Database Syst Rev. 2012 Dec 12;12:CD007419. doi: 10.1002/14651858.CD007419.pub3.

Altre valutazioni economiche

Koleva D, De Compadri P, Virgili G, Nobili A, Garattini L. A critical review of the full economic evaluations of pharmacological treatments for glaucoma. J Med Econ. 2008;11(4):719-41. doi: 10.3111/13696990802399548. PMID: 19450078.

Revisioni sistematiche di interventi con disegni di studio complessi: network meta-analyses (NMA)

NMAs in medicina generale (Cochrane e non-Cochrane)

1. Danese S, Fiorino G, Peyrin-Biroulet L, Lucenteforte E, Virgili G, Moja L, Bonovas S. Biological Agents for Moderately to Severely Active Ulcerative Colitis: A Systematic Review and Network Meta-analysis. Ann Intern Med. 2014;160:704-11.
2. Rosati A, Ilvento L, Lucenteforte E, Pugi A, Crescioli G, McGreevy KS, Virgili G, Mugelli A, De Masi S, Guerrini R. Comparative efficacy of antiepileptic drugs in children and adolescents: A network meta-analysis. Epilepsia. 2018;59:297-314.
3. Urban ML, Bettiol A, Mattioli I, Emmi G, Di Scala G, Avagliano L, Lombardi N, Crescioli G, Virgili G, Serena C, Mecacci F, Ravaldi C, Vannacci A, Silvestri E, Prisco D. Comparison of treatments for the prevention of fetal growth restriction in obstetric antiphospholipid syndrome: a systematic review and network meta-analysis. Intern Emerg Med. 2021 Aug;16(5):1357-1367
4. Bettiol A, Avagliano L, Lombardi N, Crescioli G, Emmi G, Urban ML, Virgili G, Ravaldi C, Vannacci A. Pharmacological Interventions for the Prevention of Fetal Growth Restriction: A Systematic Review and Network Meta-Analysis. Clin Pharmacol Ther. 2021 Jul;110(1):189-199.
5. Tramacere I, Benedetti MD, Capobussi M, Castellini G, Frau S, Gonzalez-Lorenzo M, Moja L, Filippini G, Lucenteforte E, Perduca V, Virgili G. Adverse effects of immunotherapies for multiple sclerosis: a network meta-analysis. Cochrane Database of Systematic Reviews (revision submitted).

NMAs in Oculistica (Cochrane e non-Cochrane)

1. Virgili G, Parravano M, Evans JR, Gordon I, Lucenteforte E. Anti-vascular endothelial growth factor for diabetic macular oedema: a network meta-analysis. Cochrane Database Syst Rev. 2018 Oct 16;10:CD007419.
2. Virgili G, Novielli N, Menchini F, Murro V, Giacomelli G. Pharmacological Treatments for Neovascular Age-Related Macular Degeneration: Can Mixed Treatment  Comparison Meta-Analyses be Useful? Curr Drug Targets. 2010 Oct 1.

Cochrane reviews con disegni complessi: Diagnostic Test Accuracy (DTA) reviews

Medicina Generale

1. Lombardi G, Crescioli G, Cavedo E, Lucenteforte E, Casazza G, Bellatorre AG, Lista C, Costantino G, Frisoni G, Virgili G, Filippini G. Structural magnetic resonance imaging for the early diagnosis of dementia due to Alzheimer's disease  in people with mild cognitive impairment. Cochrane Database Syst Rev. 2020 Mar 2;3:CD009628.

Oculistica

2. Jindal, Anish, Irene Ctori, Gianni Virgili, Ersilia Lucenteforte, and John G Lawrenson. Non-Contact Tests for Identifying People at Risk of Primary Angle Closure Glaucoma. The Cochrane Database of Systematic Reviews 5 (May 2020): CD012947. 
3. Optical coherence tomography (OCT) for detection of macular oedema in patients with diabetic retinopathy. Cochrane. Virgili G, Menchini F, Murro V, Peluso E, Rosa F, Casazza G. Cochrane Database Syst Rev. 2011 Jul 6;(7):CD008081. 
4. Michelessi M, Lucenteforte E, Oddone F, Brazzelli M, Parravano M, Franchi S, Ng SM, Virgili G. Optic nerve head and fibre layer imaging for diagnosing glaucoma. Cochrane Database Syst Rev. 2015 Nov 30;2015(11):CD008803. doi: 10.1002/14651858.CD008803.pub2. PMID: 26618332; PMCID: PMC4732281.
5. Virgili G, Menchini F, Casazza G, Hogg R, Das RR, Wang X, Michelessi M. Optical coherence tomography (OCT) for detection of macular oedema in patients with diabetic retinopathy. Cochrane Database Syst Rev. 2015 Jan 7;1:CD008081. (update)

Cochrane reviews di eventi avversi

1. Moja L, Lucenteforte E, Kwag KH, Bertele V, Campomori A, Chakravarthy U, D'Amico R, Dickersin K, Kodjikian L, Lindsley K, Loke Y, Maguire M, Martin DF, Mugelli A, Mühlbauer B, Püntmann I, Reeves B, Rogers C, Schmucker C, Subramanian ML, Virgili G. Systemic safety of bevacizumab versus ranibizumab for neovascular age-related macular degeneration

Cochrane reviews citate in Linee Guida (fonte: Cochrane Collaboration)

Ordine discendente per n. di citazioni

1. Anti-vascular endothelial growth factor for diabetic macular oedema            Virgili G, Parravano M, Menchini F, Evans JR Eyes and Vision Group 10.1002/14651858.CD007419.pub4         

• Ministry of Health Malaysia; Academy of Medicine Malaysia; Malaysia Endocrine & Metabolic Society; Diabetes Malaysia; Family Medicine Specialists Association of Malaysia. Clinical Practice Guidelines: Management of Type 2 Diabetes Mellitus (6th Edition). Putrajaya, Malaysia: Ministry of Health Malaysia; 2020. Available from: http://www.acadmed.org.my/index.cfm?menuid=67
• Corcóstegui B, Durán S, González-Albarrán MO, Hernández C, Ruiz-Moreno JM5, Salvador J, Udaondo P, Simó R. Update on Diagnosis and Treatment of Diabetic Retinopathy: A Consensus Guideline of the Working Group of Ocular Health (Spanish Society of Diabetes and Spanish Vitreous and Retina Society). J Ophthalmol. 2017;2017:8234186. doi: 10.1155/2017/8234186. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488240/
• American Academy of Ophthalmology. Comprehensive Adult Medical Eye Evaluation. (AAO Preferred Practice Patterns Guidelines). San Francisco (CA): American Academy of Ophthalmology (AAO); 2015. Available from: http://www.aaojournal.org/article/S0161-6420(15)01269-5/pdf
• Müller UA, Uebel T, Abholz HH, Landgraf R, Hammes H-P, Bertram B, Agostini H, Lemmen KD, Haller N, Loskill H . Nationale VersorgungsLeitlinie: Pra¨vention und Therapie von Netzhautkomplikationen bei Diabetes. [National Care Guideline: Prevention and Treatment of Retinal Complications of Diabetes]. Berlin: Ärztliches Zentrum für Qualität in der Medizin (ÄZQ); 2015. Available from: http://www.awmf.org/leitlinien/detail/ll/nvl-001b.html

2. 10.1002/14651858.CD003925.pub3           

• Grupo de trabajo de la Guía de Práctica Clínica para las Distrofias Hereditarias de Retina. Guía de Práctica Clínica para las Distrofias Hereditarias de Retina. [Clinical Practice Guidelines for Hereditary Dystrophies of the Retina]. Galicia: Ministerio de Sanidad, Servicios Sociales e Igualdad. Servicio de Evaluación del Servicio Canario de la Salud; 2017. Available from: https://portal.guiasalud.es/wp-content/uploads/2018/12/GPC_565_DHR_SESCS_compl.pdf
• American Academy of Ophthalmology. Vision Rehabilitation (AAO Preferred Practice Pattern Guidelines). San Francisco (CA): American Academy of Ophthalmology; 2017. Available from: https://www.aao.org/preferred-practice-pattern/vision-rehabilitation-ppp-201
• American Academy of Ophthalmology, Vision Rehabilitation Committee. Vision rehabilitation. (AAO Preferred Practice Pattern Guidelines). San Francisco (CA): American Academy of Ophthalmology; 2012 [updated May 2013]. Available from: http://one.aao.org/CE/PracticeGuidelines/PPP_Content.aspx?cid=6da6f0f7-d333-4578-ae61-c325d67fa2f8

3. Virgili G, Parravano M, Menchini F, Brunetti M    Eyes and Vision Group            10.1002/14651858.CD007419.pub3

• American Academy of Ophthalmology. Age-Related Macular Degeneration (AAO Preferred Practice Pattern Guidelines). San Francisco (CA): American Academy of Ophthalmology; 2019. Available from: https://www.aaojournal.org/article/S0161-6420(19)32091-3/pdf
• American Academy of Ophthalmology. Age-Related Macular Degeneration  - Updated 2015. (AAO Preferred Practice Pattern Guidelines). San Francisco (CA): American Academy of Ophthalmology; 2014 [updated January 2015]. Available from: http://www.aao.org/preferred-practice-pattern/age-related-macular-degeneration-ppp-2015
• Mitchell P, Wong TY; Diabetic Macular Edema Treatment Guideline Working Group. Management paradigms for diabetic macular edema. Am J Ophthalmol 2014;157(3):505-13.e1-8. Available from:http://www.ajo.com/article/S0002-9394(13)00735-6/pdf

4. Evans JR, Michelessi M, Virgili G       Eyes and Vision Group10.1002/14651858.CD011234.pub2

• Suomalaisen Lääkäriseuran Duodecimin, Suomen Silmälääkäriyhdistyksen, Suomen Silmäkirurgiyhdistyksen asettama työryhmä, Finnish Medical Society Duodecim, Finnish Ophthalmologist Association, Finnish Eye Surgeon Association. Duodecim Käypä Hoito: Kaihi (aikuiset). [Duodecim Current Care Guidelines: Cataracts (adults)]. Helsinki: Finnish Medical Society Duodecim; February, 2019. Available from: http://www.kaypahoito.fi/web/kh/suositukset/suositus?id=hoi50035
• American Academy of Ophthalmology. Cataract in the Adult Eye  (AAO Preferred Practice Pattern Guidelines). San Francisco (CA): American Academy of Ophthalmology; 2017. Available from: https://www.aao.org/preferred-practice-pattern/cataract-in-adult-eye-ppp-2016
• National Institute for Health and Care Excellence. Cataracts in adults: management. London: National Institute for Health and Care Excellence; 2017. (NICE NG77). [Issued October 2017]. Available from: https://www.nice.org.uk/guidance/ng77/evidence

4. Virgili G, Bini A       Eyes and Vision Group CD004763.pub2

• The State Expert Center of the Ministry of Health of Ukraine. СКРИНІНГ У ПЕРВИННІЙ ДОПОМОЗІ КЛІНІЧНА НАСТАНОВА, ЗАСНОВАНА НА ДОКАЗАХ. [Screening in primary care. Evidence-based guideline]. Kiev, Ukraine: The State Expert Center of the Ministry of Health of Ukraine; 2019. Available from: https://www.dec.gov.ua/wp-content/uploads/2019/11/2018_09_21_kn_scrinning.pdf
• Siu AL, Bibbins-Domingo K, Grossman DC, Baumann LC, Davidson KW, Ebell M, García FA, Gillman M, Herzstein J, Kemper AR, Krist AH, Kurth AE, Owens DK, Phillips WR, Phipps MG, Pignone MP; US Preventive Services Task Force (USPSTF). Screening for Impaired Visual Acuity in Older Adults: US Preventive Services Task Force Recommendation Statement. JAMA. 2016 Mar;315(9):908-14. Available from: http://jama.jamanetwork.com/article.aspx?articleid=2497913

5. Giansanti F, Eandi CM, Virgili G           Eyes and Vision Group 10.1002/14651858.CD006931.pub2         

• American Academy of Ophthalmology. Age-Related Macular Degeneration (AAO Preferred Practice Pattern Guidelines). San Francisco (CA): American Academy of Ophthalmology; 2019. Available from: https://www.aaojournal.org/article/S0161-6420(19)32091-3/pdf
• Royal College of Ophthalmologists. Age-Related Macular Degeneration: Guidelines for Management. London: Royal College of Ophthalmologists; 2013, September. Available  from: https://www.rcophth.ac.uk/wp-content/uploads/2014/12/2013-SCI-318-RCOphth-AMD-Guidelines-Sept-2013-FINAL-2.pdf

6. Virgili G, Parravano M, Evans JR, Gordon I, Lucenteforte E         Eyes and Vision Group            10.1002/14651858.CD007419.pub6           

• National Institute for Health and Care Excellence. Technology appraisal guidance: Fluocinolone acetonide intravitreal implant for treating chronic diabetic macular oedema in phakic eyes after an inadequate response to previous therapy. London: National Institute for Health and Care Excellence; 2019. (NICE TA613). [Issued November 2019]. Available from: https://www.nice.org.uk/guidance/ta613
• American Academy of Ophthalmology. Diabetic Retinopathy (AAO Preferred Practice Pattern Guidelines). San Francisco (CA): American Academy of Ophthalmology; 2019. Available from: https://www.aaojournal.org/article/S0161-6420(19)32092-5/pdf

7. Virgili G, Menchini F, Murro V, Peluso E, Rosa F, Casazza GEyes and Vision Group            10.1002/14651858.CD008081.pub2

• Müller UA, Uebel T, Abholz HH, Landgraf R, Hammes H-P, Bertram B, Agostini H, Lemmen KD, Haller N, Loskill H . Nationale VersorgungsLeitlinie: Pra¨vention und Therapie von Netzhautkomplikationen bei Diabetes. [National Care Guideline: Prevention and Treatment of Retinal Complications of Diabetes]. Berlin: Ärztliches Zentrum für Qualität in der Medizin (ÄZQ); 2015. Available from: http://www.awmf.org/leitlinien/detail/ll/nvl-001b.html
• American Optometric Association. Evidence-based clinical practice guideline: eye care of the patient with diabetes mellitus. St. Louis (MO): American Optometric Association; 2014. Available from: http://www.aoa.org/Documents/EBO/EyeCareOfThePatientWithDiabetesMellitus%20CPG3.pdf

8. Virgili G, Menchini F, Casazza G, Hogg R, Das RR, Wang X, Michelessi M            Eyes and Vision Group            10.1002/14651858.CD008081.pub3           

• American Optometric Association. Eye Care of the Patient with Diabetes Mellitus (Second Edition). St Louis, Missouri: American Optometric Association; 2019. Available from: https://www.aoa.org/optometrists/tools-and-resources/evidence-based-optometry/evidence-based-clinical-practice-guidlines/cpg-3--eye-care-of-the-patient-with-diabetes-mellitus
• Müller UA, Uebel T, Abholz HH, Landgraf R, Hammes H-P, Bertram B, Agostini H, Lemmen KD, Haller N, Loskill H . Nationale VersorgungsLeitlinie: Pra¨vention und Therapie von Netzhautkomplikationen bei Diabetes. [National Care Guideline: Prevention and Treatment of Retinal Complications of Diabetes]. Berlin: Ärztliches Zentrum für Qualität in der Medizin (ÄZQ); 2015. Available from: http://www.awmf.org/leitlinien/detail/ll/nvl-001b.html

7. Moja L, Lucenteforte E, Kwag KH, Bertele V, Campomori A, Chakravarthy U, D'Amico R, Dickersin K, Kodjikian L, Lindsley K, Loke Y, Maguire M, Martin DF, Mugelli A, Mühlbauer B, Püntmann I, Reeves B, Rogers C, Schmucker C, Subramanian ML, Virgili G            Eyes and Vision Group            10.1002/14651858.CD011230.pub2

• American Academy of Ophthalmology. Age-Related Macular Degeneration (AAO Preferred Practice Pattern Guidelines). San Francisco (CA): American Academy of Ophthalmology; 2019. Available from: https://www.aaojournal.org/article/S0161-6420(19)32091-3/pdf
• Duodecim. Evidence summaries for the Finnish Current Care Guideline: Wet Age-Related Macular Degeneration. Tampere, Finland: The Finnish Medical Society Duodecim and Duodecim Medical Publications; 2016 June. Available from: http://www.kaypahoito.fi/documents/25721/0/AMD_evidence_summaries_20160629.pdf/39cfd5cb-d244-4f3c-b592-75ec9a6af598

8. Reading aids for adults with low vision            Virgili G, Acosta R, Grover LL, Bentley SA, Giacomelli G     Eyes and Vision Group            10.1002/14651858.CD003303.pub3           

• American Academy of Ophthalmology. Vision Rehabilitation (AAO Preferred Practice Pattern Guidelines). San Francisco (CA): American Academy of Ophthalmology; 2017. Available from: https://www.aao.org/preferred-practice-pattern/vision-rehabilitation-ppp-2017

9. Laser treatment of drusen to prevent progression to advanced age-related macular degeneration    Parodi MB, Virgili G, Evans JR          Eyes and Vision Group 10.1002/14651858.CD006537.pub2     

• Royal College of Ophthalmologists. Age-Related Macular Degeneration: Guidelines for Management. London: Royal College of Ophthalmologists; 2013, September. Available  from: https://www.rcophth.ac.uk/wp-content/uploads/2014/12/2013-SCI-318-RCOphth-AMD-Guidelines-Sept-2013-FINAL-2.pdf

1. Macular translocation for neovascular age-related macular degeneration       Eandi CM, Giansanti F, Virgili GEyes and Vision Group       10.1002/14651858.CD006928.pub2

• Royal College of Ophthalmologists. Age-Related Macular Degeneration: Guidelines for Management. London: Royal College of Ophthalmologists; 2013, September. Available  from: https://www.rcophth.ac.uk/wp-content/uploads/2014/12/2013-SCI-318-RCOphth-AMD-Guidelines-Sept-2013-FINAL-2.pdf

1. Anti-vascular endothelial growth factor for diabetic macular oedema: a network meta-analysis  Virgili G, Parravano M, Evans JR, Gordon I, Lucenteforte E     Eyes and Vision Group       10.1002/14651858.CD007419.pub5      

• American Optometric Association. Eye Care of the Patient with Diabetes Mellitus (Second Edition). St Louis, Missouri: American Optometric Association; 2019. Available from: https://www.aoa.org/optometrists/tools-and-resources/evidence-based-optometry/evidence-based-clinical-practice-guidlines/cpg-3--eye-care-of-the-patient-with-diabetes-mellitus

2. Optic nerve head and fibre layer imaging for diagnosing glaucoma       Michelessi M, Lucenteforte E, Oddone F, Brazzelli M, Parravano M, Franchi S, Ng SM, Virgili G. Eyes and Vision Group       10.1002/14651858.CD008803.pub2      

• National Guideline Centre; National Institute for Health and Care Excellence (commissioner). Glaucoma: diagnosis and management. London: National Institute for Health and Care Excellence; 2017. (NICE NG81).  [Issued 2009; partially updated October 2017]. Available from: https://www.nice.org.uk/guidance/ng81

3. Vitrectomy for idiopathic macular hole            Parravano M, Giansanti F, Eandi CM, Yap YC, Rizzo S, Virgili GEyes and Vision Group10.1002/14651858.CD009080.pub2

• American Academy of Ophthalmology. Idiopathic Macular Hole (AAO Preferred Practice Pattern Guidelines). San Francisco (CA): American Academy of Ophthalmology; 2019. Available from: https://www.aaojournal.org/article/S0161-6420(19)32093-7/pdf

4. Monotherapy laser photocoagulation for diabetic macular oedema        Jorge EC, Jorge EN, Botelho M, Farat JG, Virgili G, El Dib R  Eyes and Vision Group 10.1002/14651858.CD010859.pub2         

• American Academy of Ophthalmology. Diabetic Retinopathy (AAO Preferred Practice Pattern Guidelines). San Francisco (CA): American Academy of Ophthalmology; 2019. Available from: https://www.aaojournal.org/article/S0161-6420(19)32092-5/pdf

5. Descemet's membrane endothelial keratoplasty (DMEK) versus Descemet's stripping automated endothelial keratoplasty (DSAEK) for corneal endothelial failure            Stuart AJ, Romano V, Virgili G, Shortt AJ       Eyes and Vision Group 10.1002/14651858.CD012097.pub2

• College of Optometrists. Clinical Management Guidelines - Fuchs Endothelial Corneal Dystrophy. London: College of Optometrists; 2019 May. Available from: https://www.college-optometrists.org/guidance/clinical-management-guidelines/fuchs-endothelial-corneal-dystrophy.html

6. Ab interno trabecular bypass surgery with Schlemm´s canal microstent (Hydrus) for open angle glaucoma          Otarola F, Virgili G, Shah A, Hu K, Bunce C, Gazzard G Eyes and Vision Group            10.1002/14651858.CD012740.pub2

• American Academy of Ophthalmology. Primary Open-Angle Glaucoma. (AAO Preferred Practice Patterns Guidelines). San Francisco (CA): American Academy of Ophthalmology; 2020. Available from: https://www.aao.org/preferred-practice-pattern/primary-open-angle-glaucoma-ppp

Ricerca sui metodi per condurre e valutare le revisioni sistematiche

1. Yang B, Mallett S, Takwoingi Y, Davenport CF, Hyde CJ, Whiting PF, Deeks JJ, Leeflang MMG; QUADAS-C Group†, Bossuyt PMM, Brazzelli MG, Dinnes J, Gurusamy KS, Jones HE, Lange S, Langendam MW, Macaskill P, McInnes MDF, Reitsma JB, Rutjes AWS, Sinclair A, de Vet HCW, Virgili G, Wade R, Westwood ME. QUADAS-C: A Tool for Assessing Risk of Bias in Comparative Diagnostic Accuracy Studies. Ann Intern Med. 2021 Nov;174(11):1592-1599. doi: 10.7326/M21-2234. Epub 2021 Oct 26. PMID: 34698503.
2. Korevaar DA, Cohen JF, Spijker R, Saldanha IJ, Dickersin K, Virgili G, Hooft L, Bossuyt PM. Reported estimates of diagnostic accuracy in ophthalmology conference abstracts were not associated with full-text publication. J Clin Epidemiol. 2016 Nov;79:96-103.
3. Lindsley K, Li T, Ssemanda E, Virgili G, Dickersin K. Interventions for Age-Related Macular Degeneration: Are Practice Guidelines Based on Systematic Reviews? Ophthalmology. 2016 Apr;123(4):884-97
4. Korevaar DA, Cohen JF, Spijker R, Saldanha IJ, Dickersin K, Virgili G, Hooft L, Bossuyt PM. Reported estimates of diagnostic accuracy in ophthalmology conference abstracts were not associated with full-text publication. J Clin Epidemiol. 2016 Jun 13.
5. Moja L, Fernandez del Rio MP, Banzi R, Cusi C, D'Amico R, Liberati A, Lodi G, Lucenteforte E, Minozzi S, Pecoraro V, Virgili G, Parmelli E. Multiple systematic reviews: methods for assessing discordances of results. Intern Emerg Med. 2012 Dec;7(6):563-8. doi: 10.1007/s11739-012-0846-1.
6. Lucenteforte E, Moja L, Pecoraro V, Conti AA, Conti A, Crudeli E, Galli A, Gensini GF, Minnelli M, Mugelli A, Proietti R, Shtylla J, D'Amico R, Parmelli E,  Virgili G. Discordances originated by multiple meta-analyses on interventions for myocardial infarction: a systematic review. J Clin Epidemiol. 2015 Mar;68(3):246-56.
7. Korevaar DA, Cohen JF, de Ronde MW, Virgili G, Dickersin K, Bossuyt PM. Reporting Weaknesses in Conference Abstracts of Diagnostic Accuracy Studies in Ophthalmology. JAMA Ophthalmol. 2015 Oct 8:1-5.
8. Lindsley K, Li T, Ssemanda E, Virgili G, Dickersin K. Interventions for Age-Related Macular Degeneration: Are Practice Guidelines Based on Systematic Reviews? Ophthalmology. 2016 Apr;123(4):884-97.
9. Michelessi M, Lucenteforte E, Miele A, Oddone F, Crescioli G, Fameli V, Korevaar DA, Virgili G. Diagnostic accuracy research in glaucoma is still incompletely reported: An application of Standards for Reporting of Diagnostic Accuracy Studies (STARD) 2015. PLoS One. 2017 Dec 14;12(12):e0189716.
10. Virgili G, Michelessi M, Miele A, Oddone F, Crescioli G, Fameli V, Lucenteforte E. STARD 2015 was reproducible in a large set of studies on glaucoma. PLoS One. 2017 Oct 12;12(10):e0186209
11. Evans JR, Gordon I, Lawrenson JG, Parker R, Rowe FJ, Virgili G, Li T, Ramke J; Cochrane Eyes and Vision Priority Setting Steering Group. Identifying priority review questions for Cochrane Eyes and Vision: protocol for a priority setting exercise. BMJ Open. 2021 Jun 25;11(6):e046319. doi: 10.1136/bmjopen-2020-046319. PMID: 34172546; PMCID: PMC8237719.
12. Br J Ophthalmol. 2014 Apr;98(4):421-2.

Editoriali nel Cochrane Corner section di Internal and Emergency Medicine

1. Moja L, Virgili G, Liberati A, Gensini GF, Gusinu R, Conti AA. Scales to climb borderline personalities: when science goes nowhere. Intern Emerg Med. 2007 Dec;2(4):315-7.
2. Virgili G, Conti AA, Murro V, Gensini GF, Gusinu R. Systematic reviews of diagnostic test accuracy and the Coc2hrane collaboration. Intern Emerg Med. 2009 Jun;4(3):255-8. PubMed PMID: 19357825.
3. Virgili G, Conti AA, Moja L, Gensini GF, Gusinu R. Heterogeneity and meta-analyses: do study results truly differ? Intern Emerg Med. 2009 Aug 28. 
4. Virgili G, Koleva D, Garattini L, Banzi R, Gensini GF. Utilities and QALYs in health economic evaluations: glossary and introduction. Intern Emerg Med. 2010 Aug;5(4):349-1.
5. Virgili G, Amato L, Lindsley K, Evans J. Outcome measures in health research: from assessing validity to outcome reporting. Intern Emerg Med. 2015 Nov 24.  
6. Virgili G, Lindsley K, Amato L, Evans J. Outcome measures in trials: the systematic reviewer's point of view. Intern Emerg Med. 2015 Nov 24. 

Editoriali su Cochrane reviews in altri giornali peer-review

1. Evans J, Li T, Virgili G, Wormald R; Cochrane Eyes and Vision. Cochrane Eyes and Vision: a perspective introducing Cochrane Corner in Eye. Eye (Lond). 2019Jun;33(6):882-886.
2. Michelessi M, Azuara-Blanco A, Virgili G. Cochrane Corner: evidence on the management of primary angle closure glaucoma. Eye (Lond). 2022 Jan 15. doi: 10.1038/s41433-021-01848-9. Epub ahead of print. PMID: 35031705.

Altre revisioni sistematiche non Cochrane su riviste indicizzate con disegni di studio standard e alternativi

Diagnostic test accuracy reviews: medicina generale

Diagnostic test accuracy reviews: oculistica

1. Oddone F, Lucenteforte E, Michelessi M, Rizzo S, Donati S, Parravano M, Virgili G. Macular versus Retinal Nerve Fiber Layer Parameters for Diagnosing Manifest Glaucoma: A Systematic Review of Diagnostic Accuracy Studies. Ophthalmology. 2016 May;123(5):939-49.
2. Tsang AC, Ahmadi Pirshahid S, Virgili G, Gottlieb CC, Hamilton J, Coupland SG.Hydroxychloroquine and Chloroquine Retinopathy: A Systematic Review Evaluating the Multifocal Electroretinogram as a Screening Test. Ophthalmology. 2015 Mar 27. pii: S0161-6420(15)00126-8. doi: 10.1016/j.ophtha.2015.02.011.
3. Virgili G, Menchini F, Dimastrogiovanni AF, Rapizzi E, Menchini U, Bandello F, Gortana Chiodini R. Optical coherence tomography versus stereoscopic fundus photography or biomicroscopy for diagnosing diabetic macular edema: a systematic review. Invest Ophthalmol Vis Sci 2007; 48:4963–4973.

Revisioni di intervento: medicina generale

Revisioni di intervento: oculistica

2. Br J Ophthalmol. 2020 Nov;104(11):1512-1518. doi: 10.1136/bjophthalmol-2019-315623. Epub 2020 Feb 12. PMID: 32051133.

Meta-analisi di studi su eventi avversi con disegno randomizzato o non-randomizzato (non Cochrane)

Medicina genereale

1. Moja L, Piatti A, Pecoraro V, Ricci C, Virgili G, Salanti G, Germagnoli L, Liberati A, Banfi G. Timing Matters in Hip Fracture Surgery: Patients Operated within 48 Hours Have Better Outcomes. A Meta-Analysis and Meta-Regression of over 190,000 Patients. PLoS One. 2012;7(10):e46175.

Oculistica

1. Reibaldi M, Fallico M, Avitabile T, Bonfiglio V, Russo A, Castellino N, Parisi G, Longo A, Pulvirenti A, Boscia F, Virgili G. Risk of Death Associated With Intravitreal Anti-Vascular Endothelial Growth Factor Therapy: A Systematic Review and Meta-analysis. JAMA Ophthalmol. 2019 Nov 21.
4. Govetto A, Virgili G, Menchini F, Lanzetta P, Menchini U. A Systematic Review of Endophthalmitis after Microincisional versus 20-Gauge Vitrectomy. Ophthalmology. 2013 Jun 11. doi:pii: S0161-6420(13)00341-2.10.1016/j.ophtha.2013.04.010.  
5. Miele A, Govetto A, Fumagalli C, Donati S, Biagini I, Azzolini C, Rizzo S, Virgili G. Ocular hypertension and glaucoma following vitrectomy: A Systematic Review. Retina. 2017 Apr 19.

6          Menchini F, Toneatto G, Miele A, Donati S, Lanzetta P, Virgili G. Antibiotic prophylaxis for preventing endophthalmitis after intravitreal injection: a systematic review. Eye (Lond). 2018 Sep;32(9):1423-1431.

Revisioni sistematiche di studi animali

1. Moja L, Pecoraro V, Ciccolallo L, Dall'Olmo L, Virgili G, Garattini S. Flaws, in animal studies exploring statins and impact on meta-analysis. Eur J Clin Invest. 2014;44(6):597-612.

Altra ricerca rilevante

Studi diagnostici primari in medicina generale

1. Vultaggio A, Matucci A, Virgili G, Rossi O, Filı L, Parronchi P, Romagnani S, Maggi E. Influence of total serum IgE levels on the in vitro detection of b-lactams-specific IgE antibodies. Clinical & Experimental Allergy, 1–7 doi: 10.1111/j.1365-2222.2009.03219.
2. Colagrande S, Pasquinelli F, Mazzoni ML, Belli G, Virgili G. MR-DwI of healthy liver parenchyma: repeatability and reproducibility of apparent diffusion coefficient (ADC) measurement.
3. Matucci A, Pratesi S, Petroni G, Nencini F, Virgili G, Milla M, Maggi E, Vultaggio A. Allergological in vitro and in vivo evaluation of patients with hypersensitivity reactions to infliximab. Clin Exp Allergy. 2013 Jun;43(6):659-64. doi: 10.1111/cea.12098. PubMed PMID: 23711128.
4. Cappellini I, Picciafuochi F, Bartolucci M, Matteini S, Virgili G, Adembri C.  Evaluation of diaphragm thickening by diaphragm ultrasonography: a reproducibility and a repeatability study. J Ultrasound. 2020 May 1.
5. Vultaggio, Alessandra, Emanuele Vivarelli, Gianni Virgili, Ersilia Lucenteforte, Alessandro Bartoloni, Carlo Nozzoli, Alessandro Morettini, et al. “Prompt Predicting of Early Clinical Deterioration of Moderate-to-Severe COVID-19  Patients: Usefulness of a Combined Score Using IL-6 in a Preliminary Study.” The Journal of Allergy and Clinical Immunology. In Practice, June 2020. https://doi.org/10.1016/j.jaip.2020.06.013.

Epidemiologia, salute pubblica e salute globale

1. Piyasena P, Olvera-Herrera VO, Chan VF, Clarke M, Wright DM, MacKenzie G, Virgili G, Congdon N. Vision impairment and traffic safety outcomes in low-income and middle-income countries: a systematic review and meta-analysis. Lancet Glob Health. 2021 Oct;9(10):e1411-e1422. doi: 10.1016/S2214-109X(21)00303-X. Epub 2021 Aug 16. PMID: 34411516.
2. Virgili G, Gatta G, Ciccolallo L, Capocaccia R, Biggeri A, Crocetti E, Lutz JM, Paci E; EUROCARE Working Group.  Survival from Uveal Melanoma in Europe. Archives of Ophthalmology 2008 Oct;126(10):1413-8.
3. Virgili G, Gatta G, Ciccolallo L, Capocaccia R, Biggeri A, Crocetti E, Lutz JM, Paci E; EUROCARE Working Group. Incidence of Uveal Melanoma in Europe. Ophthalmology 2007;114:2309–2315.
4. Virgili G, Angi M, Molinari A, Casotto V. Cox regression was used to compare the measurement error of two tests vs. a gold standard. J Clin Epidemiol. 2007 Apr;60(4):345-9.
5. Virgili G, Angi M, Heede S, Rodriguez D, Bottega E, Molinari A. PowerRefractor versus Canon R-50 Autorefraction to assess refractive error in children: a community-based study in Ecuador. Optom Vis Sci. 2007 Feb;84(2):144-8.
6. Saint S, Bartoloni A, Virgili G, Mannelli F, Fumagalli S, di Martino P, Conti AA, Kaufman SR, Gensini GF, Conti A. Marked variability in adherence to hand hygiene: A 5-unit observational study in  Tuscany. Am J Infect Control. 2009 Jan 8.
7. Saint S, Conti A, Bartoloni A, Virgili G, Mannelli F, Fumagalli S, di Martino P, Conti AA, Kaufman SR, Rogers MAM, Gensini GF. Improving healthcare worker hand hygiene adherence before patient contact: a before-and-after five-unit multimodal intervention in Tuscany
8. Virgili G, Barchielli A, Balzi D, Matarrese D, Paci E, Gusinu R, Zuppiroli A, Gensini GF. [Mortality after myocardial infarction: when the health local organization network has a role in interpreting the markers of the National Agency for Regional Health Services]. Epidemiol Prev. 2013 Mar-Jun;37(2-3):176-9.
9. Mavi S, Chan VF, Virgili G, Biagini I, Congdon N, Piyasena P, Yong AC, Ciner EB, Kulp MT, Candy TR, Collins M, Bastawrous A, Morjaria P, Watts E, Masiwa LE, Kumora C, Moore B, Little JA. The Impact of Hyperopia on Academic Performance Among Children: A Systematic Review. Asia Pac J Ophthalmol (Phila). 2022 Jan 20. doi: 10.1097/APO.0000000000000492. Epub ahead of print.   

Studi sull’impiego di risorse sanitarie e di esito basati su database elettronici amministrativi

1. Virgili G, Barchielli A, Balzi D, Matarrese D, Paci E, Gusinu R, Zuppiroli A, Gensini GF. [Mortality after myocardial infarction: when the health local organization network has a role in interpreting the markers of the National Agency for Regional Health Services]. Epidemiol Prev. 2013 Mar-Jun;37(2-3):176-9.
2. Giuseppe Roberto (ARS), Francesco Attanasio (UniFi) Gianni Virgili (UniFi), Rosa Gini (ARS), Claudio Marinai (ESTAR). Pattern of use of intravitreal drugs with antiangiogenic properties for age-related macular degeneration and other vascular retinopathies. Available at the Tuscany Regional Health Agency at https://www.ars.toscana.it/files/progetti/farmacoepidemiologia/report_antiVEGF.pdf
3. Virgili G, Tosi GM, Figus M, Rizzo S, Murro V, Mucciolo DP, Roberto G, Gini R. Use of anti-vascular endothelial growth factor drugs for eye disease in Tuscany:  Development and test of indicators of treatment intensity. Eur J Ophthalmol. 2019 Oct 30:1120672119885045.
4. Scondotto G, Sultana J, Ientile V, Ingrasciotta Y, Fontana A, Copetti M, Mirabelli E, Trombetta CJ, Rapisarda C, Reibaldi M, Avitabile T, Longo A, Toro PI, Vadalà M, Cillino S, Virgili G, Gini R, Leoni O, Pollina Addario SW, Cananzi  P, La Cavera C, Puzo MR, De Sarro G, De Francesco A, Trifirò G. How Have Intravitreal Anti-VEGF and Dexamethasone Implant Been Used in Italy? A Multiregional, Population-Based Study in the Years 2010-2016. Biomed Res Int. 2020 Jan 11;2020:7582763.
5. Scondotto G, Crisafulli S, Antonazzo IC, Virgili G, Trifirò G, Sultana J. Assessing intravitreal anti-VEGF drug safety using real-world data: methodological challenges in observational research. Expert Opin Drug Saf. 2021 Jul 27:1-10. doi: 10.1080/14740338.2021.1957829. Epub ahead of print. PMID: 34304672.

Contributi alla preparazione di linee guida e raccomandazioni

3. Linee Guida Italiane per la Degenerazione Maculare Legata all'Età (DMLE) , 2011 https://www.fondazionebietti.it/it/linee_guida; tra le prime raccomandazioni che hanno utilizzato il metodo GRADE in Itala supportate dal Ministero della Salute in http://www.quadernidellasalute.it/imgs/C_17_pubblicazioni_1708_allegato.pdf
4. Standard Italiani per la Cura del Diabete Mellito 2016. Roma, Italia: AMD-SID; 2016. http://www.standarditaliani.it/home.php . 

Attività collaborative internazionale

Collaborazione con CEV@US (precedentemente all Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, ora alla Colorado University, Denver, Colorado) per il supporto editoriale alle revisioni sistematiche di oculistica (2016-in poi) 

Il ruolo del Prof. Gianni Virgili come Executive Editor dell'American Journal of Ophthalmology fa parte di un accordo con Cochrane Eyes and Vision US   (CEV@US) e si basa su un grant del National Eye Institute, National Institutes of Health a sostegno degli Associate Editors in riviste di oftalmologia e optometria.

Reference: prof. Tianjing Li, MD, MHS, PhD, Associate Professor, Center for Clinical Trials and Evidence Synthesis

Collaborazione con WHO come membro del Technical Working Group per il WHO Package of Refractive Error Interventions (2018-in poi)

Il primo step di questo progetto è stato la definizione di un evidence-based Package of Refractive Error Interventions (PREI), che sarà parte del Package of Comprehensive Eyecare Interventions. Il PREI sarà utilizzato dai paesi per pianificare, preventivare e integrare gli interventi sull'errore di rifrazione a tutti i livelli di erogazione dei servizi (cure di comunità, primarie, secondarie e terziarie). Il PREI sosterrà i paesi nel determinare a) i costi associati all'attuazione degli interventi sull'errore di rifrazione e b) la forza lavoro, le attrezzature e i materiali di consumo necessari per l'attuazione degli interventi sull'errore di rifrazione.

Gianni Virgili ha fornito supporto tecnico per il recupero, l'utilizzo o la preparazione di linee guida cliniche e revisioni sistematiche a sostegno di questo Pacchetto come membro di Cochrane Eyes and Vision.

Reference:  Dr. Megan McCoy, Technical Officer Management of Noncommunicable Diseases, Disability, Violence and Injury Prevention (NVI); World Health Organization  l  20, Avenue Appia  l  CH-1211 Geneva 27. Phone: +41 22 791 2021; E-mail: mccoym@who.int 

Collaborazione con WHO come membro del Technical Working Group for the WHO Package of Rehabilitation Interventions for Vision rehabilitation (2018-in poi)

This will be a further step of the collaboration between Cochrane Eyes and Vision and WHO as part of the Package of Comprehensive Eyecare Interventions. Gianni Virgili has provided provide technical support for retrieving, using or planning guidelines and systematic reviews in support of this Package.

Reference:  Dr. Alexandra Rauch, MPH, Rehabilitation Programme, World Health Organization. Avenue Appia 20, 1211 Geneva 27; Email: raucha@who.int

Membro del DEMON UK Research Network on Dementia per il progetto “Eye and vision biomarkers associated with dementia: an umbrella review of diagnostic accuracy systematic reviews”,

Review in svolgimento con protocollo registrato su PROSPERO CRD42021287196

Ruoli istituzionali nazionali

Membro del Comitato Tecnico Nazionale per la Prevenzione della Cecità, Ministero della Salute (dal Giugno 2017)

Membro della Commissione Permanente Linee Guida dell’Organismo Toscano per il Governo Clinico Regione Toscana Giunta Regionale Direzione "Diritti di Cittadinanza e Coesione Sociale", Regione Toscana.

Ricerca collaborativa nazionale

Consulente scientifico della Fondazione GB Bietti per l’Oftalmologia IRCCS per la Ageing Network of IRCCS Research Institutes in Italia.

Resoconti e pubblicazioni sulla multimorbidità in pazienti con deficit visivo e sulla politerapia in pazienti che ricevono terapia intravitreale per le retinopatie.

Consulente scientifico della Unione Italiana Ciechi per INVAT (Istituto nazionale valutazione ausili e tecnologie) un registro per la valutazione delle assistive technologies in soggetti ipovedenti.

Il registro intende valutare l'uso di dispositivi ottici ed elettronici da parte di persone ipovedenti. La ricerca pertinente è stata presentata ed è in fase di revisione su rivista indicizzata.

Insegnamento di metodi per la sintesi di evidenze in contesti internazionali

Workshop On Developing A Systematic Review

15 - 17 January 2014. Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. Responsabile: Prof. Kay Dickersin.

1st Congress Of Evidence-Based Ophthalmology and Clinical Eye Research,   approvato dalla Chinese Doctoral Association.

Lecture on systematic review methods, October 9-11, 2015. Wenzhou, China. Responsabile: dr. Yuanbo Liang, dr. Tianjing Li.

Systematic Review methods, Master in Public Health -  Global Health strand, Queen’s University Belfast (UK)

Programmato il 15 Febbraio 2022. Centre for Public Health, Queen’s University Belfast. Responsabile: Prof. Michael Donnelly

Numerose presentazioni al Royal College of Ophthalmologists (London, UK) con Cochrane eyes and Vision Group

Ruoli istituzionali di docenza universitaria

Nazionali

Membro del Collegio di Dottorato in Neuroscienze, Università di Firenze, dal Novembre -2010

Supervisor di n. 7 Dottorandi, incluso il supporto alla preparazione della tesi.

Direttore della Scuola di Specializzazione in Oftalmologia presso la Clinica Oculistica, AOU Careggi, Università di Firenze, con nomina nel 2014  (attualmente in aspettativa).

Precedentemente VicePresidente del Corso di Laurea in Medicina e del GAV (Gruppo di Autovalutazione) del Corso di Laurea in Medicina, Università di Firenze.

Precedentente Coordinatore del Modulo ‘Specialità Medico-Chirurgiche 4’ del Corso di Laurea in Medicina, Università di Firenze (Otorinolaringoiatria, Audiologia, Chirurgia Maxillo-Faciale, Odontostomatologia, corso integrato)

Internazionali

Co-Supervisor di un PhD Student in Global Health, Queen’s University Belfast (UK)

Revisione sistematica in svolgimento sulla salute mentale dei bambini con difetto visivo (da November 2021). Supervisor: Prof. Nathan Congdon

Insegnamento Universitario in Medicina ed altre professioni sanitarie nel contesto nazionale

Corso di Laura e Specializzazioni in Medicina

1. Nominato nel marzo 2014 Direttore della Scuola di Specializzazione in Oftalmologia, Università di Firenze ed AOU Careggi
2. Professore Associato in Oftalmologia, Università di Firenze ed AOU Careggi (2005-)

• Didattica: Corso di Laurea in Medicina, modulo Oftalmologia; Coordinatore ORL, Audiologia, Chirurgia Maxillo-Facciale, Corso integrato 2009-2018

• Insegnamento: Corso di Specializzazione in Oftalmologia

• Relatore: supporto a diversi studenti di medicina per la preparazione e presentazione di tesi, di cui 25 dal 2014

• Didattica: Corso di Laurea in Medicina, modulo Oftalmologia;

• Insegnamento: Corso di Specializzazione in Oftalmologia

4. Firenze (2000-2002)

• Insegnamento: Corso di Laurea in Medicina e Chirurgia, modulo Oftalmologia

• Insegnamento: Corso di Specializzazione in Oftalmologia

• Insegnamento: Corso di Laurea in Medicina, Modulo di Oftalmologia: Semeiotica Oculare – 20 ore

Insegnamento Universitario della metodologia della ricerca e revisioni sistematiche nel contesto nazionale

Metodologia di ricerca e revisioni sistematiche nei corsi:

1) Master in Epidemiologia, Meyer Children University Hospital, Firenze, Italia: lezioni sulla conduzione della revisione sistematica, 20-22 maggio 2019; organizzatore: dott. Salvatore De Masi, Epidemiologia clinica, Ospedale Universitario Pediatrico Meyer, Firenze, Italia.

2) Laurea specialistica biennale per tecnici sanitari: Scienze delle Professioni Sanitarie Tecniche Diagnostiche, Facoltà di Medicina e Chirurgia, Università degli Studi di Firenze, Sede di Empoli (Insegnamento MED/50 – Scienze tecniche applicate alle evidenze scientifiche e appropriatezza). AA 2005/2006 al 2013/2014

3) Laurea triennale per tecnici dedicati alla salute pubblica e alla prevenzione delle malattie: Corso di Laurea Specialistica in Scienze delle professioni sanitarie della prevenzione (Informatica applicata alla sanità pubblica D1). AA. 2009/2010

Docente in corsi sulla metodologia per le revisioni sistematiche per personale ospedaliero e di agenzie sanitarie nel contesto nazionale

Coordinatore o docente in una o più edizioni di corsi sulle revisioni sistematiche: insegnamento di EBM e metodologia delle revisioni sistematiche:

1) Corso sui metodi di ricerca rivolto al personale del Comitato Etico e dell'Ufficio Sperimentazione Clinica in Toscana, Metodi di accuratezza dei test diagnostici: Azienda Ospedaliera Universitaria AOU Meyer, Firenze 15 settembre 2015.

2) Corso “Il Governo Clinico: Conoscenza Della Ebm. Corso di Area Vasta di 8 ore per i Medici Specialisti Ambulatoriali” tenuto in 4 edizioni dalla ASL10 nei giorni 30/10/07 - 6/11/07 - 20/11/07 - 27/11/07, diretto a Specialisti operanti in ambulatori pubblici in Toscana (Coordinatore dott. Stefano Guidotti).

3) Corso “Apprendimento Della Metodologia Delle Sperimentazioni E Delle Ricerche Clinico-Epidemiologiche” rivolto a Specialisti operanti in ambito ambulatoriale pubblico in Toscana, 14.04.09 e 05.05.09 presso Agenzia per la Formazione – AUSL 11, Sovigliana/Vinci (FI)

4) Corso “La pratica professionale basata sulle evidenze” del Servizio Tecnico Sanitario Aziendale della AOU Careggi, 2 edizioni (novembre 2009, febbraio 2010).

5) Corso “La Revisione Sistematica Cochrane. Azienda Ospedaliero-Universitaria Careggi (più edizioni)

Sintesi di ruoli editoriali

6. PLOS ONE (2015): Editor di 123 articoli presentati nei campi: oftalmologia; revisioni sistematiche, ricerca sui servizi sanitari

Peer-review for indexed journals, McMaster Online Rating of Evidence (MORE)

1) Peer Review di alcune centinaia di submission per oltre 60 riviste scientifiche

2) McMaster Online Rating of Evidence (MORE): 107 (dal 2006)

Grant reviewer per National Funding Agencies

1. Health and Medical Research Fund from The Government of the Hong Kong Special Administrative Region (HKSAR)
2. USPSTF (USA)
3. Austrian Science Fund
4. Swiss National Science Foundation
5. The Netherlands Organisation for Health Research and Development (ZonMw)
6. CINECA (Italy)
7. Royal College of Optometrists (UK)
8. India Alliance DBT Wellcome Trust (India)

Patents

Versione Italiana di MNREAD reading charts (con: Department of Psychology, University of Minnesota, USA, Prof. Gordon Legge, 1998)

Finanziamenti per la ricerca

Titolo: “INTegration of Administrative and Clinical data To investigate processes and outcomes of eye care (INTACT)”

Bando Salute 2018 – Regione Toscana

http://www301.regione.toscana.it/bancadati/atti/Contenuto.xml?id=5242075&nomeFile=Decreto_n.975_del_16-01-2020-Allegato-A

Principal Investigator: Gianni Virgili

Finanziamento: 216.000 euro

Il progetto mira ad estrarre informazioni cliniche da cartelle cliniche elettroniche semistrutturate su circa diecimila pazienti con malattia retinica raccolte presso l'Azienda Ospedaliero Universitaria Careggi, Firenze, Italia. L'intelligenza artificiale verrà utilizzata per questo scopo e la valutazione da parte di un medico verrà utilizzata come training e gold standard. E’ stato pianificato il collegamento ai dati regionali in collaborazione con il Dipartimento di Ingegneria e l'Agenzia sanitaria regionale della Toscana.

Titolo: Patients phenotyping and genotyping and innovative treatments for retinitis pigmentosa

 “Ministero della Salute – “Bando Ricerca Finalizzata anno 2016” – Programmi di Rete, Programme Code: NET-2016-02363765

Coordinatore del programma e Principal investigator nella fase di sottomissione e avvio: Gianni Virgili

Finanziamento complessivo: 1,399,231 euro

Finanziamento locale: 700.000 euro

Link: http://www.salute.gov.it/imgs/C_17_bandi_135_listaFile_itemName_6_file.pdf

Summary: Il progetto mira a organizzare una rete italiana che unisce la ricerca di base e la pratica clinica per sviluppare nuovi strumenti per la diagnosi della retinite pigmentosa (RP) e trattamenti innovativi per la malattia. Per prima cosa è stato reclutato un gran numero di pazienti con RP che sarà sottoposto a una raffinata valutazione oftalmologica. Successivamente verranno indirizzati all'analisi genetica molecolare mediante la tecnologia NGS. I dati clinici saranno archiviati in un database dedicato e sarà organizzato una raccolta dei biomateriali. Questa coorte sarà ulteriormente valutata per l'impatto clinico di nuovi possibili approcci diagnostici come la valutazione computerizzata delle immagini del fondo oculare, l'angiografia OCT (angioOCT) e i biomarcatori circolanti immunologici. Allo stesso tempo verranno sviluppate alcune prospettive di trattamenti innovativi: in particolare neuroprotettori cannabinoidi, progettazione di farmaci sulla base delle mutazioni rilevate, approcci in vitro e in vivo (modello Zebrafish RP) di terapia molecolare e cellulare.

Titolo: “Guidelines and diagnostic questions: how to support doctors and patients with understanding uncertainty in diagnostic test interpretation”

Finanziamento Alla Ricerca Fondazione Cassa Di Risparmio – Bando 2017

Code: #24383

Principal Investigator: Gianni Virgili

Finanziamento: 40.000 euro

Riepilogo: Il progetto ha svolto e pubblicato una revisione diagnostica dell'accuratezza di diversi tipi di termometri per rilevare la febbre in vari contesti. La fase di disseminazione comprende formazione metodologica e workshop per i clinici.

Titolo: “Safety of Long-acting Nitrates, Ivabradine, Nicorandil and Ranolazine to treat or prevent stable angina: systematic review and meta-analysis”

Progetti Di Ricerca Indipendente Sui Farmaci - Bando 2012

Code: FARM12T4BK

Principal Investigator: Ersilia Lucenteforte

Role: co-investigator

Finanziamento: 67.000 euro

Summary: Network meta-analysis per studiare gli effetti negativi dei nitrati di nuova generazione ad azione prolungata.

NIHR Evidence Synthesis Programme Incentive Awards Scheme 2021 - Call: 21/531– finalizzato alla conduzione di revisioni Cochrane con alta priorità

Ruolo: Gianni Virgili Lead Applicant

Title 1: Interventions for myopia control in children: a living systematic review and network meta‐analysis. Cochrane Living review and Network Meta-analysis.  Lead author: John G. Lawrenson, City University London (UK)

Awarded 10,000 GPB

Title 2: Prognostic factors for the development and progression of proliferative diabetic retinopathy in people with diabetic retinopathy. Cochrane prognostic review. Lead author: Noemi Lois, Queen’s University Belfast (UK)

Awarded 10,000 GPB

HTA Project: NIHR134593 - Study of technologies for the diagnosis of angle closure Awarded  3rd February 2022: Finanziamento previsto circa 500.000 GBP

Email: netspostawardsetup@nihr.ac.uk

Lead applicant: Prof Augusto Azuara-Blanco

Co-applicant: Prof. Gianni Virgili

Centre for Public Health, Queen’s University Belfast, UK

Esperienza manageriale in ambito ospedaliero

1. Coordinatore   del Centro regionale per l’Educazione e la Riabilitazione Visiva (CERV), Ospedale di Careggi, Firenze, Italia. giugno 2015 – novembre 2020
2. Direttore dell'Unità Operativa di Oculistica “SOD Oftalmologia per la Continuità Ospedale Territorio”, attualmente “Ottica Fisiopatologica” Azienda Ospedaliero-Universitaria Careggi, Firenze, Italia (da marzo 2013, in aspettativa da gennaio 2021)
3. per l'analisi dei dati di performance e appropriatezza presso il  Controllo di Gestione, anche nell'ambito della discussione del Budget, con una vasta esperienza maturata nella codifica dei ricoveri ospedalieri e sull’uso delle risorse per quanto riguarda i database relativi alle attività di degenza , ambulatoriale, dispensazione di farmaci, da novembre 2011 a marzo 2013.

4. Dirigente medico aggiunto (Responsabile Servizi Sanitari) del Dipartimento Organi di Senso  dell'Azienda Ospedaliero-Universitaria Careggi, Firenze (2004-2008  responsabilità sanitaria delle UO Otorinolaringoiatria, Chirurgia Maxillo-Facciale, Audiologia, Odontoiatria , Chirurgia Plastica e Oftalmologia.

5. Consulente della Direzione Generale Diritto alla Salute e Politiche di Solidarietà, della Regione Toscana con contributi specifici (2008-2010):

• individuazione di ricoveri chirurgici inappropriati basati sul sistema DRG;

• valutazione della letteratura su specifici interventi non farmacologici;

6. Responsabile Accreditamento e Qualità dell'Unità Operativa di Oculistica, Azienda Ospedaliero-Universitaria Careggi, Firenze (2004-2008): supporto ai processi di miglioramento della qualità e di gestione del rischio.

Progetti incentrati sulla relazione paziente-medico e sull'empowerment del paziente

1) Membro della Commissione di Medical Humanities dell'Università degli Studi di Firenze, 2010-2015

2) ASTROLABIO: il progetto ha avuto l'obiettivo di coinvolgere ed informare i pazienti   affetti da patologia retinica DAI Organi di Senso dell'Azienda Ospedaliero-Universitaria Careggi sostenuto da ANPAS Toscana (coordinatrice dr.ssa Silvia Bruni) 2006-2007.

3) EUFEMIA: focus group guidato da psicologi e finalizzato alla produzione di materiale informativo scritto e di facile comprensione per pazienti con degenerazione maculare, SOD Oculistica dell'Azienda Ospedaliero-Universitaria Careggi 2006-200

Formazione

Educazione medica universitaria

1. Laurea in Medicina e Chirurgia, Università of Trieste,   20 luglio 1988 (voto 110/110 cum laude).
2. Specializzazione in Oftalmologia, Università of Trieste,   21 dicembre 1992 (voto 50/50 cum laude).
3.  Master di secondo livello in Epidemiology, ISI Foundation – Università di Torino, gennaio 2005 (voto 110/110).

Corsi in epidemiologia e Biostatistica (ordine cronologico)

1. Introduzione alla statistica medica (1995, Milano, 1 settimana, Prof. Marubini,)           
2. Erasmus Summer Programme (agosto 2000, Rotterdam, 1 mese,  Prof. A. Hofmann)

• Epidemiology – Introduction
• Epidemiology – Advanced
• Introduction to data analysis
• Regression analysis
• Topics in Evidence-based medicine

1. La comunicazione scienteifica (Novembre 2000, Roma, 4 giorni, Istituto Superiore di Sanità)
2. European Educational Programme in Epidemiology (giugno 25 –luglio 13, 2001,  Firenze, 4 settimane, International Agency for Research on Cancer: Prof. Saracci)
3. Analisi di misure ripetute (S. Miniato 17-21 maggio 2004,   prof. Annibale Biggeri, 5 giorni)
4. Statistical design and analysis of genetic epidemiology studies (giugno 20 – 24, 2005, Firenze, 5 giorni, all’interno del European Educational Programme in Epidemiology 2005, by David Clayton; International Agency for Research on Cancer: Prof. Saracci)
5. Analilsi di dati spazialmente strutturati (Novembre 2005, Bologna;   module   Master in Biostatistics, Università of Bologna, 5 giorni; prof. A. Biggeri )

Epidemiologia and Biostatistica: metodi Bayesiani per la sintesi di evidenze

1. Introduction to Bayesian analysis using Winbugs - Cambridge, September  11-12, 2007 (MRC Biostatistical Unit, University of Cambridge; prof. D. Spiegelhalter, dr. D. Lunn; duration: 2 giorni);
2. Winbugs in Health Economics Evaluation -  Cambridge, December 3-4, 2007 (MRC Biostatistical Unit, University of Cambridge; prof. D. Spiegelhalter, dr. R. Nixon; duration: 2 giornni);
3. Evidence synthesis for decision modeling: 5 day course – Venice (June 29 – July 3, 2009; Prof. Tony Ades, dr. Alex Sutton, etc, University of Leicester, University of Bristol; duration: 5 giorni).

Training in valutazioni economiche

1. Corso MIOS sulle misure di qualità della vita (giugno 2000, Milano – Istituto Mario Negri, 2 giorni, dr. Apollone)
2. Corso MIOS sulla utility analysis (febbraio 2001, Milan – Istituto Mario Negri, 2 giorni, dr. Apollone)

Corsi  Principali all’interno della Cochrane Collaboration:

1. Diagnostic test accuracy systematic reviews I (marzo 2005, Milan, 3 giorni, Centro Cochrane Italiano, Istituto Mario Negri);
2. Diagnostic test accuracy systematic reviews II (giugno 2006, Milan, 3 grioni, Istituto Carlo Besta);
3. Numerosi workshops in varie edizioni del Cochrane Colloquium (dal 2006);
4. Training come editor dedicato alle Diagnostic test accuracy systematic reviews (2 brevi coursi: Amsterdam 22-23 novembre 2007; Londra, 10 giugno 2008);
5. Statistical methods for diagnostic test accuracy reviews (17-19 luglio 2013, Brimingham University, UK).
6. Cochrane Risk of Bias tool for Non-Randomised studies (formerly ACROBAT-NRSI, ora ROBINS-I), Parigi 1-3 Dec 2014.
7. Cochrane Risk of Bias methods training for Review Groups (10-12 luglio 2019, Bristol University, UK).
8. Cochrane risk of bias 2.0: train the trainers. Evidence Synthesis Ireland luglio 6-7 e settembre 6, 2021.

Incorso: Formazione universitaria in PostGraduate education

Studente (quale nuovo Academic Staff della Queen’s University Belfast) del corso Postgraduate Certificate in Higher Education Teaching (iniziato gennaio 2022) https://www.qub.ac.uk/schools/ssesw/study/postgraduate-taught/PGCHET/

Il Postgraduate Certificate in Higher Education Teaching (PGCHET) ) è rivolto principalmente al nuovo personale accademico e fornisce una qualifica formale per l'insegnamento e l'apprendimento nell'istruzione superiore. Il PGCHET è accreditato Higher Education Academy (Advance HE).

Abilità linguistiche

1. Madre lingua Italiano
2. Inglese: advanced level EC School Malta (82/100 in due diverse occasioni negli dal 2005)
3. Inglese: Occupational English Test (OET) certification ottenuta il 8 febbraio 2020 (punteggi 420, 420, 430, 400 su 500 in Listening, Reading, Speaking, Writing).
4. Inglese: uso quotidiano come Consultant al Belfast Health and Social Care Trust e Professore alla Queen’s University Belfast (Northern Ireland, UK) dall’Aprile 2021
5. Spanish: consocenza di base                                                                              

Software

1. Standard software
2. Software per analisi statistiche (Stata – conoscenza approfondita; Winbugs)
3. Software per reference management (Mendeley, Endnote)

Pratica medica  in cliniche universitarie

1. Cultore della Materia di Oculistica: A.O. S. Maria della Misericordia, Policlinico Universitario di Udine (1993-1996)

2.            Dirigente Medico di Oculistica: A.O. S. Maria della Misericordia, Policlinico Universitario di Udine (1996-2000). Specialista in retina medica e trattamento laser e coordinatore del servizio; attivo anche nei servizi di uveite e ipovisione

3. Dirigente Medico di Oculistica:  Azienda Ospedaliero-Universitaria Careggi, Florence (2000-2002) Specialista in retina medica e trattamento laser e coordinatore del servizio
4. Ricercatore a tempo indeterminato e dirigente medico:  Clinica Oculistica, Università di Firenze (2002-2005). Specialista in retina medica e trattamento laser
5. Professore Associato di Oftalmologia e dirigente medico:  Clinica Oculistica, Università di Firenze (2005 in poi). Specialista in retina medica e trattamento laser

Autorizzo l’uso dei miei dati personali in base alla legge D.Lgs. 196/2003 e UE 2016/679

See CV

Biosketch

Gianni Virgili is Professor of Ophthalmology at the University of Florence, and has been clinical professor at CPH, Queen’s University Belfast, honorary consultant at Belfast Health and Social Care Trust (2021-September 2023). Current director of the  clinical unit SOD Ottica Fisiopatologica at Careggi University Hospital. He has been Director of the Ophthalmology Residency Programme, and has been Coordinator of the regional Center for Vision Education and Rehabilitation at the Careggi Hospital in Florence, Italy. He has been a medical retina specialist since 1992.

He achieved a Master’s degree in Epidemiology at the University of Turin, Italy, in 2005 and has received extensive training in biostatistics and research methods, particularly in systematic reviews and meta-analyses. In support of the Hospital Medical Management he could also develop health management skills and knowledge of performance indicators and administrative hospital data across all medical specialties. He is collaborating with the Regional Health Agency in pharmacoepidemiology studies in Tuscany. Gianni is an experienced user of Stata biostatistical software, including for meta-analyses. He also uses Winbugs to fit Bayesian meta-analysis  models with sparse data, such as rare adverse events.

He has collaborated particularly with Cochrane, in which he has the current following editorial roles: Editor of the Cochrane Eyes and Vision (2006); Co-coordinating Editor of the  Diagnostic Test Accuracy Satellite Cochrane Eyes and Vision (2011); Editor of the Cochrane Diagnostic Test Accuracy Working Group (2011).

He is an Editorial Board member of the journal Internal and Emergency Medicine (HTA and Clinical Evidence section, 2010), an Academic Editor of the journal PLOS ONE (2015) and an Executive Editor of the American Journal of Ophthalmology (2016).

• Author of 385 publications in Index Medicus on PubMed (ORCID: 0000-0002-9960-2989).
• Scopus H-index: 48; ID: 7006732630, with 309 titles and 7357 citations.
• Google Scholar H index: 50, citations 11118           .

His main areas of clinical interest include primary research on the diagnosis and treatment of medical retina disorders, visual function and low vision rehabilitation.  Gianni is an expert in conducting systematic reviews of interventions and diagnostic test accuracy studies in eyes and vision as well as in other medical specialties. This methodological skill has enable him to provide editorial, methodological, and statistical support in other research fields, including neurology, immunology, allergology, radiology, laboratory medicine, anesthesiology and orthopedics. He has also published epidemiological reports and studies using registry-based and administrative electronic data, particularly working with EUROCARE and RARECARE cancer registries network and the Regional Health Agency in Tuscany.

He is involved in an international collaborative projectwith the US Satellite of Cochrane Eyes and Vision (Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health), with the aim of  supporting Associate Editors in ophthalmology and optometry journals that are dedicated to improving the quality of published evidence synthesis  (grant from the National Eye Institute, National Institutes of Health).

He is a member of the Technical Working Group for the WHO Package of Refractive Error Interventions and the WHO Package of Rehabilitation Interventions for Vision rehabilitation. In this project, as a senior member of Cochrane Eyes and Vision, Gianni Virgili will provide technical support to the project regarding retrieving, using or preparing systematic reviews and clinical guidelines.

Supervisor in the Neurosciences Doctorate, Univ. of Florence

Member of the Neurosciences Doctorate Collegium of Professors, University of Florence, since November 2010

Supervisor of n. 9 PhD students, including support to thesis preparation and presentation.

Supervisor of MPH Global Health student at Queen’s University Belfast

1. since November 2020

Teaching: Research methodology and Evidence-Based Medicine

Other University Courses

Methodology of research and systematic reviews in two courses:

1)       1-year Master’s Degree in Epidemiology, Meyer Children University Hospital, Florence, Italy: lessons on systematic review conduction, 20-22 May 2019; organizer: dr. Salvatore De Masi, clinical epidemiology, Meyer Children University Hospital, Florence, Italy.

2)       2-year second-level degree for technicians dedicated to diagnostic tests: Scienze delle Professioni Sanitarie Tecniche Diagnostiche, Facoltà di Medicina e Chirurgia, Università degli Studi di Firenze, Sede di Empoli (Insegnamento MED/50 – Scienze tecniche applicate  alle evidenze scientifiche e appropriatezza). AA 2005/2006 to 2013/2014

3)       3-year degree for technicians dedicated to public health and prevention of disease:

1. Corso di Laurea Specialistica in Scienze delle professioni sanitarie della prevenzione (Informatica applicata alla sanità pubblica D1). AA. 2009/2010

Courses for Health Agencies and Hospital Personnel

1)       Coordinator or teacher in one or more editions of courses on systematic reviews:

2)       Corso “LA REVISIONE SISTEMATICA COCHRANE. Azienda Ospedaliero-Universitaria Careggi

3)       Corso “IL GOVERNO CLINICO: CONOSCENZA DELLA EBM. Corso di Area Vasta di 8 ore per i Medici Specialisti Ambulatoriali” tenuto in 4 edizioni dalla ASL10 nei giorni 30/10/07 - 6/11/07 - 20/11/07 - 27/11/07, in collaborazione con il referente degli Animatori di Formazione dr. Stefano Guidotti.

4)       Corso“APPRENDIMENTO DELLA METODOLOGIA DELLE SPERIMENTAZIONI E DELLE RICERCHE CLINICO-EPIDEMIOLOGICHE” diretto agli Specialisti Ambulatoriali della Toscana e svolto in 2 edizioni il 14.04.09 e 05.05.09 presso la Agenzia per la Formazione – AUSL 11, Sovigliana/Vinci (FI)

5)       Corso “La pratica professionale basata sulle evidenze” organizzato dal  Servizio Tecnico Sanitario Aziendale della AOU Careggi, svolto attualmente in 2 edizioni (novembre 2009, febbraio 2010) e del quale sono previste ulteriori 4 edizioni

6)     Workshop on Developing a Systematic Review, 15 - 17 January 2014. Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

Job description: teaching of EBM and methodology of systematic reviews to university students and health professionals

Four high-impact publications since 2014

1. Oddone F, Lucenteforte E, Michelessi M, Rizzo S, Donati S, Parravano M, Virgili G. Macular versus Retinal Nerve Fiber Layer Parameters for Diagnosing Manifest Glaucoma: A Systematic Review of Diagnostic Accuracy Studies. Ophthalmology. 2016 May;123(5):939-49. doi: 10.1016/j.ophtha.2015.12.041. Epub 2016 Feb 15. PubMed PMID: 26891880.

https://www.ncbi.nlm.nih.gov/pubmed/26891880

https://www.scopus.com/record/display.uri?eid=2-s2.0-84958280617&origin=resultslist&sort=plf-f&src=s&sid=46603660A5E48FE2237CD8C9478A8D3D.wsnAw8kcdt7IPYLO0V48gA%3a140&sot=autdocs&sdt=autdocs&sl=17&s=AU-ID%287006732630%29&relpos=22&citeCnt=5&searchTerm=

Year 2016

Impact: 46 citations

This review was published on the lead clinical journal in eyes and vision and conducted a meta-analysis of 34 diagnostic test accuracy studies comparing macular with RNFL parameters using optical coherence tomography to diagnose manifest glaucoma. This study was based on a previous Cochrane review assessing the accuracy of RNFL and optic nerve head parameters in 106 studies including the latest generation of three different devices. The review established that macular parameters were similar or slightly inferior to RNFL parameters, contrarily to what was claimed by some authors.

2. Virgili G, Parravano M, Menchini F, Evans JR. Anti-vascular endothelial growth factor for diabetic macular oedema. Cochrane Database Syst Rev. 2014 Oct 24;(10):CD007419.

doi: 10.1002/14651858.CD007419.pub4. Review. PubMed PMID: 25342124.

https://www.ncbi.nlm.nih.gov/pubmed/25342124

https://www.scopus.com/record/display.uri?eid=2-s2.0-84925437893&origin=resultslist&sort=plf-f&src=s&sid=5ECE3456A3AE98530A29C9FE29F9EBA6.wsnAw8kcdt7IPYLO0V48gA%3a400&sot=autdocs&sdt=autdocs&sl=17&s=AU-ID%287006732630%29&relpos=45&citeCnt=60&searchTerm=

Year 2014

Impact: 79 citations(Scopus)

this review confirmed that antiVEGF therapy is more effective than laser for treatment of diabetic macular oedema and estimated effects more precisely than individual studies. The review also added that no safety concerns are found regarding all serious systemic adverse events and some vascular complications (ATC thromboembolic events). Safety concerns were still widespread in recent years. The review suggested that there seemed to be small differences in efficacy between on-label and off-label drugs and suggested the need for a network meta-analysis comparing aflibercept, bevacizumab and ranibizumab. Such Cochrane review is being published next month.

Mentioned in guidelines:

• American Academy of Ophthalmology. Comprehensive Adult Medical Eye Evaluation. (AAO Preferred Practice Patterns Guidelines). San Francisco (CA): American Academy of Ophthalmology (AAO); 2015. Available from: http://www.aaojournal.org/article/S0161-6420(15)01269-5/pdf
• Müller UA, Uebel T, Abholz HH, Landgraf R, Hammes H-P, Bertram B, et al. Nationale VersorgungsLeitlinie: Prävention und Therapie von Netzhautkomplikationen bei Diabetes. [National Care Guideline: Prevention and Treatment of Retinal Complications of Diabetes]. Berlin: Ärztliches Zentrum für Qualität in der Medizin (ÄZQ); 2015. Available from: http://www.awmf.org/leitlinien/detail/ll/nvl-001b.html
• Italian guidelines for the diagnosis and treatment of diabetic retinopathy. Italian Society of Diabetology (SID) http://www.iapb.it/IMG/pdf/retinopatia-diabetica-linee_guida_2015.pdf

3. Moja L, Lucenteforte E, Kwag KH, Bertele V, Campomori A, Chakravarthy U, D'Amico R, Dickersin K, Kodjikian L, Lindsley K, Loke Y, Maguire M, Martin DF, Mugelli A, Mühlbauer B, Püntmann I, Reeves B, Rogers C, Schmucker C, Subramanian  ML, Virgili G. Systemic safety of bevacizumab versus ranibizumab for neovascular  age-related macular degeneration. Cochrane Database Syst Rev. 2014 Sep 15;(9):CD011230. doi: 10.1002/14651858.CD011230.pub2. Review. PubMed PMID: 25220133; PubMed Central PMCID: PMC4262120.

https://www.ncbi.nlm.nih.gov/pubmed/25220133

https://www.scopus.com/record/display.uri?eid=2-s2.0-84911381185&origin=resultslist&sort=plf-f&src=s&sid=5ECE3456A3AE98530A29C9FE29F9EBA6.wsnAw8kcdt7IPYLO0V48gA%3a400&sot=autdocs&sdt=autdocs&sl=17&s=AU-ID%287006732630%29&relpos=51&citeCnt=74&searchTerm=

Year 2014

Impact: 133 citations (Scopus)

The review demonstrated the systemic safety of off-label bevacizumab as compared to on-label ranibizumab injected intravitreally for treatment of age-related macular degeneration. A generic signal regarding an increase of severe systemic adverse effects with bevacizumab vs. ranibizumab came from the NIH-sponsored CATT trial and gave origin to a long-lasting debate on the use of off-label bevacizumab, which costs 20 times less than ranibziumab per-patient, see:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137040/

http://www.bmj.com/bmj/section-pdf/893755?path=/bmj/350/8002/Feature.full.pdf

http://www.bmj.com/content/350/bmj.h1654

http://www.bmj.com/content/350/bmj.h2573

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695272/

http://www.cochranelibrary.com/editorial/10.1002/14651858.ED000090

This review demonstrated found SAEs and arterial thromboembolic event occurrence with both drugs.

Mentioned in guidelines:

• Duodecim. Evidence summaries for the Finnish Current Care Guideline: Wet Age-Related Macular Degeneration. Tampere, Finland: The Finnish Medical Society Duodecim and Duodecim Medical Publications; 2016 June. Available from: http://www.kaypahoito.fi/documents/25721/0/AMD_evidence_summaries_20160629.pdf/39cfd5cb-d244-4f3c-b592-75ec9a6af598

4. Danese S, Fiorino G, Peyrin-Biroulet L, Lucenteforte E, Virgili G, Moja L, Bonovas S. Biological agents for moderately to severely active ulcerative colitis: a systematic review and network meta-analysis. Ann Intern Med. 2014 May  20;160(10):704-11. doi: 10.7326/M13-2403. Review. PubMed PMID: 24842416.

https://www.ncbi.nlm.nih.gov/pubmed/24842416

https://www.scopus.com/record/display.uri?eid=2-s2.0-84901257923&origin=resultslist&sort=plf-f&src=s&sid=5ECE3456A3AE98530A29C9FE29F9EBA6.wsnAw8kcdt7IPYLO0V48gA%3a400&sot=autdocs&sdt=autdocs&sl=17&s=AU-ID%287006732630%29&relpos=41&citeCnt=77&searchTerm=

Year 2014

Impact: 130 citations (Scopus)

This was the first review conducting indirect comparisons of anti-TNF drugs for threatment of inflammatory bowel diseases. This key issue established the need for conducting head-to-head trials.

Mentioned in Guidelines:

Bernstein CN, Eliakim A, Fedail S, Fried M, Gearry R, Goh KL, Hamid S, Khan AG, Khalif I, Ng SC, Ouyang Q, Rey JF, Sood A, Steinwurz F, Watermeyer G, LeMair  A; Review Team:.. World Gastroenterology Organisation Global Guidelines Inflammatory Bowel Disease: Update August 2015. J Clin Gastroenterol. 2016 Nov/Dec;50(10):803-818. PubMed PMID: 27741097.

International collaborative research and cooperation

Collaboration with CEV@US (Johns Hopkins University, Baltimore, MD) for editorial support to systematic reviews in eyes and vision (2016-current)

The role of  Prof. Gianni Virgili as Executive Editor of the American Journal of Ophthalmology is  part of an agreement with Cochrane Eyes and Vision US Project (CEV@US)   and based on a grant from the National Eye Institute, National Institutes of Health in supporting Associate Editors in ophthalmology and optometry journals.

Reference: prof. Tianjing Li, MD, MHS, PhD, Associate Professor, Center for Clinical Trials and Evidence Synthesis; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Room E6011, Baltimore, MD, 21205 USA. Office phone: +1-410-502-4630

Collaboration with WHO as member of the Technical Working Group for the WHO Package of Refractive Error Interventions (2018-current)

The first step of this project aims to develop an evidence-based Package of Refractive Error Interventions (PREI), which will be part of the Package of Comprehensive Eyecare Interventions. The PREI will be used by countries to plan, budget and integrate refractive error interventions at all service delivery platforms (community, primary, secondary, and tertiary care). The PREI will support countries to determine a) costs associated with the implementation of refractive error interventions, and b) workforce, equipment and consumables necessary for the implementation of refractive error interventions.

Gianni Virgili will provide technical support for retrieving, using or preparing clinical guidelines and systematic reviews in support of this Package as a member of Cochrane Eyes and Vision.

Reference:  Dr.Megan McCoy, Technical Officer Management of Noncommunicable Diseases, Disability, Violence and Injury Prevention (NVI); World Health Organization  l  20, Avenue Appia  l  CH-1211 Geneva 27

Phone: +41 22 791 2021; E-mail: mccoym@who.int 

Collaboration with WHO as member of the Technical Working Group for the WHO Package of Rehabilitation Interventions for Vision rehabilitation (2018-current)

This will be a further step of the collaboration between Cochrane Eyes and Vision and WHO as part of the Package of Comprehensive Eyecare Interventions. Gianni Virgili will provide technical support for retrieving, using or planning and preparing guidelines and systematic reviews in support of this Package.

Reference:  Dr. Alexandra Rauch, MPH, Rehabilitation Programme, World Health Organization

Avenue Appia 20, 1211 Geneva 27; Email: raucha@who.int

Title: “Guidelines and diagnostic questions: how to support doctors and patients with understanding uncertainty in diagnostic test interpretation”

FINANZIAMENTO ALLA RICERCA FONDAZIONE CASSA DI RISPARMIO – BANDO 2017

Code: #24383

Principal Investigator: Gianni Virgili

Role: Principal investigator

Funding: 40.000 euro

Summary: The project aims to prepare e diagnostic review of the accuracy of different types of thermometers to detect fever in various settings. The dissemination phase includes methodological training and workshops for clinicians.

Title: “Safety of Long-acting Nitrates, Ivabradine, Nicorandil and Ranolazine to treat or prevent stable angina: systematic review and meta-analysis”

PROGETTI DI RICERCA INDIPENDENTE SUI FARMACI - BANDO 2012

Code: FARM12T4BK

Principal Investigator: Ersilia Lucenteforte

Role: co-investigator

Funding: 67.000 euro

Summary: Network meta-analysis aiming to investigate adverse effects of new generation long-acting nitrates.

NIHR Evidence Synthesis Programme Incentive Awards Scheme 2021 - Call: 21/531

Funding scheme supporting the conduction of high priority Cochrane systematic reviews

Role: Gianni Virgili lead applicant

Title 1: Interventions for myopia control in children: a living systematic review and network meta‐analysis. Cochrane Living review and Network Meta-analysis.  Lead author: John G. Lawrenson, City University London (UK) – awarded 10,000 GPB

Title 2: Prognostic factors for the development and progression of proliferative diabetic retinopathy in people with diabetic retinopathy. Cochrane prognostic review. Lead author: Noemi Lois, Queen’s University Belfast (UK) – awarded 10,000 GPB

HTA Project: NIHR134593 - Study of technologies for the diagnosis of angle closure

February 2022: about 700.000 GBP

Email: netspostawardsetup@nihr.ac.uk

Lead applicant: Prof Augusto Azuara-Blanco

Co-applicant: Prof. Gianni Virgili

Centre for Public Health, Queen’s University Belfast, UK

NUBIRE UNIFI-FCRF “Nuovi biomarkers da imaging retinico non invasivo nelle malattie cardiovascolari e neurologiche mediante piattaforma di multimodal imaging ultra-widefield”,

May 2023

Funding provided: 220.000 euro

Lead applicant: Prof Gianni Virgili

Co-applicant: Prof. Gianni Virgili

University of Florence, Italy

, Selected publications in evidence synthesis, epidemiology, health economics, and pharmacoepidemiology

Cochrane reviews of interventions

1. van Nispen RM, Virgili G, Hoeben M, Langelaan M, Klevering J, Keunen JE, van Rens GH. Low vision rehabilitation for better quality of life in visually impaired adults. Cochrane Database Syst Rev. 2020 Jan 27;1:CD006543
2. Virgili G, Parravano M, Menchini F, Evans JR. Anti-vascular endothelial growth factor for diabetic macular oedema. Cochrane Database Syst Rev. 2014 Oct 24;(10):CD007419. doi: 10.1002/14651858.CD007419.pub4. Update in: Cochrane Database Syst Rev. 2017 Jun 22;6:CD007419. PMID: 25342124.
3. Parravano M, Menchini F, Virgili G. Antiangiogenic therapy with anti-vascular endothelial growth factor modalities for diabetic macular oedema. Cochrane Database Syst Rev. 2009 Oct 7;(4):CD007419. 
4. Rittiphairoj T, Mir TA, Li T, Virgili G. Intravitreal steroids for macular edema in diabetes. Cochrane Database Syst Rev. 2020 Nov 17;11(11):CD005656.
5. Virgili G, Michelessi M, Parodi MB, Bacherini D, Evans JR. Laser treatment of  drusen to prevent progression to advanced age-related macular degeneration. Cochrane Database Syst Rev. 2015 Oct  3;10:CD006537. doi: 10.1002/14651858.CD006537.pub3. Review. PubMed PMID: 26493180
6. Parravano M, Giansanti F, Eandi CM, Yap YC, Rizzo S, Virgili G. Vitrectomy for idiopathic macular hole. Cochrane Database Syst Rev. 2015 May 12;5:CD009080.
7. Jorge EC, Jorge EN, Botelho M, Farat JG, Virgili G, El Dib R. Monotherapy laser photocoagulation for diabetic macular oedema. Cochrane Database Syst Rev. 2018 Oct 15;10:CD010859.
8. Stuart AJ, Romano V, Virgili G, Shortt AJ. Descemet's membrane endothelial keratoplasty (DMEK) versus Descemet's stripping automated endothelial keratoplasty (DSAEK) for corneal endothelial failure. Cochrane Database Syst Rev. 2018 Jun 25;6:CD012097.
9. Li E, Donati S, Lindsley KB, Krzystolik MG, Virgili G. Treatment regimens for administration of anti-vascular endothelial growth factor agents for neovascular age-related macular degeneration. Cochrane Database Syst Rev. 2020 May5;5:CD012208.
10. Hu K, Shah A, Virgili G, Bunce C, Gazzard G. Ab interno trabecular bypass surgery with Trabectome for open-angle glaucoma. Cochrane Database Syst Rev. 2021 Feb 4;2(2):CD011693.
11. Sena DF, Kilian R, Liu SH, Rizzo S, Virgili G. Pneumatic retinopexy versus scleral buckle for repairing simple rhegmatogenous retinal detachments. Cochrane Database Syst Rev. 2021 Nov 11;11(11):CD008350.
12. Evans JR, Michelessi M, Virgili G. Laser photocoagulation for proliferative diabetic retinopathy. Cochrane Database Syst Rev. 2014 Nov 24;2014(11):CD011234
13. Sundaram V, Barsam A, Virgili G. Intravitreal low molecular weight heparin and 5-Fluorouracil for the prevention of proliferative vitreoretinopathy following retinal reattachment surgery. Cochrane Database Syst Rev. 2013 Jan 31;(1):CD006421. 
14. Parodi MB, Virgili G, Evans JR. Laser treatment of drusen to prevent progression to advanced age-related macular degeneration. Cochrane Database Syst Rev. 2009 Jul 8;(3):CD006537. doi: 10.1002/14651858.CD006537.pub2. Update in: Cochrane Database Syst Rev. 2015;10:CD006537. PMID: 19588397.
15. Virgili G, Michelessi M, Parodi MB, Bacherini D, Evans JR. Laser treatment of drusen to prevent progression to advanced age-related macular degeneration. Cochrane Database Syst Rev. 2015 Oct 23;10(10):CD006537.  UPDATE
16. Eandi CM, Giansanti F, Virgili G. Macular translocation for neovascular age-related macular degeneration. Cochrane Database Syst Rev. 2008 Oct 8;(4):CD006928. 
17. Virgili G, Bini A. Laser photocoagulation for neovascular age-related macular degeneration. Cochrane Database Syst Rev. 2007 Jul 18;(3):CD004763. 
18. Virgili G, Acosta R. Reading aids for adults with low vision. Cochrane Database Syst Rev. 2006 Oct 18;(4):CD003303. doi: 10.1002/14651858.CD003303.pub2
19. Virgili G, Acosta R, Grover LL, Bentley SA, Giacomelli G. Reading aids for adults with low vision. Cochrane Database Syst Rev. 2013 Oct 23;10(10):CD003303. UPDATE
20. Virgili G, Acosta R, Bentley SA, Giacomelli G, Allcock C, Evans JR. Reading aids for adults with low vision. Cochrane Database Syst Rev. 2018 Apr 17;4(4):CD003303. UPDATE

Cochrane reviews of interventions with economic evaluation

Virgili G, Parravano M, Menchini F, Brunetti M. Antiangiogenic therapy with anti-vascular endothelial growth factor modalities for diabetic macular oedema. Cochrane Database Syst Rev. 2012 Dec 12;12:CD007419. doi: 10.1002/14651858.CD007419.pub3.

Other economic evaluations

Koleva D, De Compadri P, Virgili G, Nobili A, Garattini L. A critical review of the full economic evaluations of pharmacological treatments for glaucoma. J Med Econ. 2008;11(4):719-41. doi: 10.3111/13696990802399548. PMID: 19450078.

Complex reviews: network meta-analyses (NMA) and Overviews of Reviews

NMAs in genereal medicine (Cochrane and non-Cochrane)

1. Danese S, Fiorino G, Peyrin-Biroulet L, Lucenteforte E, Virgili G, Moja L, Bonovas S. Biological Agents for Moderately to Severely Active Ulcerative Colitis: A Systematic Review and Network Meta-analysis. Ann Intern Med. 2014;160:704-11.
2. Rosati A, Ilvento L, Lucenteforte E, Pugi A, Crescioli G, McGreevy KS, Virgili G, Mugelli A, De Masi S, Guerrini R. Comparative efficacy of antiepileptic drugs in children and adolescents: A network meta-analysis. Epilepsia. 2018;59:297-314.
3. Urban ML, Bettiol A, Mattioli I, Emmi G, Di Scala G, Avagliano L, Lombardi N, Crescioli G, Virgili G, Serena C, Mecacci F, Ravaldi C, Vannacci A, Silvestri E, Prisco D. Comparison of treatments for the prevention of fetal growth restriction in obstetric antiphospholipid syndrome: a systematic review and network meta-analysis. Intern Emerg Med. 2021 Aug;16(5):1357-1367
4. Bettiol A, Avagliano L, Lombardi N, Crescioli G, Emmi G, Urban ML, Virgili G, Ravaldi C, Vannacci A. Pharmacological Interventions for the Prevention of Fetal Growth Restriction: A Systematic Review and Network Meta-Analysis. Clin Pharmacol Ther. 2021 Jul;110(1):189-199.
5. Tramacere I, Benedetti MD, Capobussi M, Castellini G, Frau S, Gonzalez-Lorenzo M, Moja L, Filippini G, Lucenteforte E, Perduca V, Virgili G. Adverse effects of immunotherapies for multiple sclerosis: a network meta-analysis. Cochrane Database of Systematic Reviews (revision submitted).
6. Lawrenson JG, Shah R, Huntjens B, Downie LE, Virgili G, Dhakal R, Verkicharla PK, Li D, Mavi S, Kernohan A, Li T, Walline JJ. Interventions for myopia control in children: a living systematic review and network meta-analysis. Cochrane Database Syst Rev. 2023 Feb 16;2(2):CD014758.
7. Costanzo E, Lengyel I, Parravano M, Biagini I, Veldsman M, Badhwar A, Betts M, Cherubini A, Llewellyn DJ, Lourida I, MacGillivray T, Rittman T, Tamburin S, Tai XY, Virgili G. Ocular Biomarkers for Alzheimer Disease Dementia: An Umbrella Review of Systematic Reviews and Meta-analyses. JAMA Ophthalmol. 2023 Jan 1;141(1):84-91.

NMAs in Ophthalmology (Cochrane and non-Cochrane)

1. Lawrenson_JG, Shah_R, Huntjens_B, Downie_LE, Virgili_G, Dhakal_R, Verkicharla_PK, Li_D, Mavi_S, Kernohan_A, Li_T, Walline_JJ. Interventions for myopia control in children: a living systematic review and network meta-analysis. Cochrane Database of Systematic Reviews 2023, Issue 2. Art. No.: CD014758. DOI: 10.1002/14651858.CD014758.pub2.
3. Virgili G, Novielli N, Menchini F, Murro V, Giacomelli G. Pharmacological Treatments for Neovascular Age-Related Macular Degeneration: Can Mixed Treatment  Comparison Meta-Analyses be Useful? Curr Drug Targets. 2010 Oct 1.

Cochrane reviews with complex design: Diagnostic Test Accuracy (DTA) reviews

General Medicine

1. Lombardi G, Crescioli G, Cavedo E, Lucenteforte E, Casazza G, Bellatorre AG, Lista C, Costantino G, Frisoni G, Virgili G, Filippini G. Structural magnetic resonance imaging for the early diagnosis of dementia due to Alzheimer's disease  in people with mild cognitive impairment. Cochrane Database Syst Rev. 2020 Mar 2;3:CD009628.

Oculistica

2. Jindal, Anish, Irene Ctori, Gianni Virgili, Ersilia Lucenteforte, and John G Lawrenson. Non-Contact Tests for Identifying People at Risk of Primary Angle Closure Glaucoma. The Cochrane Database of Systematic Reviews 5 (May 2020): CD012947. 
3. Optical coherence tomography (OCT) for detection of macular oedema in patients with diabetic retinopathy. Cochrane. Virgili G, Menchini F, Murro V, Peluso E, Rosa F, Casazza G. Cochrane Database Syst Rev. 2011 Jul 6;(7):CD008081. 
4. Michelessi M, Lucenteforte E, Oddone F, Brazzelli M, Parravano M, Franchi S, Ng SM, Virgili G. Optic nerve head and fibre layer imaging for diagnosing glaucoma. Cochrane Database Syst Rev. 2015 Nov 30;2015(11):CD008803. doi: 10.1002/14651858.CD008803.pub2. PMID: 26618332; PMCID: PMC4732281.
5. Virgili G, Menchini F, Casazza G, Hogg R, Das RR, Wang X, Michelessi M. Optical coherence tomography (OCT) for detection of macular oedema in patients with diabetic retinopathy. Cochrane Database Syst Rev. 2015 Jan 7;1:CD008081. (update)

Cochrane reviews of adverse events

1. Moja L, Lucenteforte E, Kwag KH, Bertele V, Campomori A, Chakravarthy U, D'Amico R, Dickersin K, Kodjikian L, Lindsley K, Loke Y, Maguire M, Martin DF, Mugelli A, Mühlbauer B, Püntmann I, Reeves B, Rogers C, Schmucker C, Subramanian ML, Virgili G. Systemic safety of bevacizumab versus ranibizumab for neovascular age-related macular degeneration

Methods research on systematic reviews

1. Yang B, Mallett S, Takwoingi Y, Davenport CF, Hyde CJ, Whiting PF, Deeks JJ, Leeflang MMG; QUADAS-C Group†, Bossuyt PMM, Brazzelli MG, Dinnes J, Gurusamy KS, Jones HE, Lange S, Langendam MW, Macaskill P, McInnes MDF, Reitsma JB, Rutjes AWS, Sinclair A, de Vet HCW, Virgili G, Wade R, Westwood ME. QUADAS-C: A Tool for Assessing Risk of Bias in Comparative Diagnostic Accuracy Studies. Ann Intern Med. 2021 Nov;174(11):1592-1599. doi: 10.7326/M21-2234. Epub 2021 Oct 26. PMID: 34698503.
2. Korevaar DA, Cohen JF, Spijker R, Saldanha IJ, Dickersin K, Virgili G, Hooft L, Bossuyt PM. Reported estimates of diagnostic accuracy in ophthalmology conference abstracts were not associated with full-text publication. J Clin Epidemiol. 2016 Nov;79:96-103.
3. Lindsley K, Li T, Ssemanda E, Virgili G, Dickersin K. Interventions for Age-Related Macular Degeneration: Are Practice Guidelines Based on Systematic Reviews? Ophthalmology. 2016 Apr;123(4):884-97
4. Korevaar DA, Cohen JF, Spijker R, Saldanha IJ, Dickersin K, Virgili G, Hooft L, Bossuyt PM. Reported estimates of diagnostic accuracy in ophthalmology conference abstracts were not associated with full-text publication. J Clin Epidemiol. 2016 Jun 13.
5. Moja L, Fernandez del Rio MP, Banzi R, Cusi C, D'Amico R, Liberati A, Lodi G, Lucenteforte E, Minozzi S, Pecoraro V, Virgili G, Parmelli E. Multiple systematic reviews: methods for assessing discordances of results. Intern Emerg Med. 2012 Dec;7(6):563-8. doi: 10.1007/s11739-012-0846-1.
6. Lucenteforte E, Moja L, Pecoraro V, Conti AA, Conti A, Crudeli E, Galli A, Gensini GF, Minnelli M, Mugelli A, Proietti R, Shtylla J, D'Amico R, Parmelli E,  Virgili G. Discordances originated by multiple meta-analyses on interventions for myocardial infarction: a systematic review. J Clin Epidemiol. 2015 Mar;68(3):246-56.
7. Korevaar DA, Cohen JF, de Ronde MW, Virgili G, Dickersin K, Bossuyt PM. Reporting Weaknesses in Conference Abstracts of Diagnostic Accuracy Studies in Ophthalmology. JAMA Ophthalmol. 2015 Oct 8:1-5.
8. Lindsley K, Li T, Ssemanda E, Virgili G, Dickersin K. Interventions for Age-Related Macular Degeneration: Are Practice Guidelines Based on Systematic Reviews? Ophthalmology. 2016 Apr;123(4):884-97.
9. Michelessi M, Lucenteforte E, Miele A, Oddone F, Crescioli G, Fameli V, Korevaar DA, Virgili G. Diagnostic accuracy research in glaucoma is still incompletely reported: An application of Standards for Reporting of Diagnostic Accuracy Studies (STARD) 2015. PLoS One. 2017 Dec 14;12(12):e0189716.
10. Virgili G, Michelessi M, Miele A, Oddone F, Crescioli G, Fameli V, Lucenteforte E. STARD 2015 was reproducible in a large set of studies on glaucoma. PLoS One. 2017 Oct 12;12(10):e0186209
11. Evans JR, Gordon I, Lawrenson JG, Parker R, Rowe FJ, Virgili G, Li T, Ramke J; Cochrane Eyes and Vision Priority Setting Steering Group. Identifying priority review questions for Cochrane Eyes and Vision: protocol for a priority setting exercise. BMJ Open. 2021 Jun 25;11(6):e046319. doi: 10.1136/bmjopen-2020-046319. PMID: 34172546; PMCID: PMC8237719.

Cochrane Corner section of Internal and Emergency Medicine

1. Moja L, Virgili G, Liberati A, Gensini GF, Gusinu R, Conti AA. Scales to climb borderline personalities: when science goes nowhere. Intern Emerg Med. 2007 Dec;2(4):315-7.
2. Virgili G, Conti AA, Murro V, Gensini GF, Gusinu R. Systematic reviews of diagnostic test accuracy and the Coc2hrane collaboration. Intern Emerg Med. 2009 Jun;4(3):255-8. PubMed PMID: 19357825.
3. Virgili G, Conti AA, Moja L, Gensini GF, Gusinu R. Heterogeneity and meta-analyses: do study results truly differ? Intern Emerg Med. 2009 Aug 28. 
4. Virgili G, Koleva D, Garattini L, Banzi R, Gensini GF. Utilities and QALYs in health economic evaluations: glossary and introduction. Intern Emerg Med. 2010 Aug;5(4):349-1.
5. Virgili G, Amato L, Lindsley K, Evans J. Outcome measures in health research: from assessing validity to outcome reporting. Intern Emerg Med. 2015 Nov 24. 
6. Virgili G, Lindsley K, Amato L, Evans J. Outcome measures in trials: the systematic reviewer's point of view. Intern Emerg Med. 2015 Nov 24. 

Editorial on Cochrane reviews in other peer-review journals

1. Evans J, Li T, Virgili G, Wormald R; Cochrane Eyes and Vision. Cochrane Eyes and Vision: a perspective introducing Cochrane Corner in Eye. Eye (Lond). 2019Jun;33(6):882-886.
2. Michelessi M, Azuara-Blanco A, Virgili G. Cochrane Corner: evidence on the management of primary angle closure glaucoma. Eye (Lond). 2022 Jan 15. doi: 10.1038/s41433-021-01848-9. Epub ahead of print. PMID: 35031705.

Non Cochrane reviews with alternative design

Diagnostic test accuracy reviews: general medicine

Diagnostic test accuracy reviews: eyes

1. Oddone F, Lucenteforte E, Michelessi M, Rizzo S, Donati S, Parravano M, Virgili G. Macular versus Retinal Nerve Fiber Layer Parameters for Diagnosing Manifest Glaucoma: A Systematic Review of Diagnostic Accuracy Studies. Ophthalmology. 2016 May;123(5):939-49.
2. Tsang AC, Ahmadi Pirshahid S, Virgili G, Gottlieb CC, Hamilton J, Coupland SG.Hydroxychloroquine and Chloroquine Retinopathy: A Systematic Review Evaluating the Multifocal Electroretinogram as a Screening Test. Ophthalmology. 2015 Mar 27. pii: S0161-6420(15)00126-8. doi: 10.1016/j.ophtha.2015.02.011.
3. Virgili G, Menchini F, Dimastrogiovanni AF, Rapizzi E, Menchini U, Bandello F, Gortana Chiodini R. Optical coherence tomography versus stereoscopic fundus photography or biomicroscopy for diagnosing diabetic macular edema: a systematic review. Invest Ophthalmol Vis Sci 2007; 48:4963–4973.

Intervention reviews: general medicine

Intervention reviews: eyes

Meta-analyses of randomised and non-randomised studies of adverse events  (non Cochrane)

Genereal Medicine

1. Moja L, Piatti A, Pecoraro V, Ricci C, Virgili G, Salanti G, Germagnoli L, Liberati A, Banfi G. Timing Matters in Hip Fracture Surgery: Patients Operated within 48 Hours Have Better Outcomes. A Meta-Analysis and Meta-Regression of over 190,000 Patients. PLoS One. 2012;7(10):e46175.

Eyes

1. Reibaldi M, Fallico M, Avitabile T, Bonfiglio V, Russo A, Castellino N, Parisi G, Longo A, Pulvirenti A, Boscia F, Virgili G. Risk of Death Associated With Intravitreal Anti-Vascular Endothelial Growth Factor Therapy: A Systematic Review and Meta-analysis. JAMA Ophthalmol. 2019 Nov 21.
4. Govetto A, Virgili G, Menchini F, Lanzetta P, Menchini U. A Systematic Review of Endophthalmitis after Microincisional versus 20-Gauge Vitrectomy. Ophthalmology. 2013 Jun 11. doi:pii: S0161-6420(13)00341-2.10.1016/j.ophtha.2013.04.010. 
5. Miele A, Govetto A, Fumagalli C, Donati S, Biagini I, Azzolini C, Rizzo S, Virgili G. Ocular hypertension and glaucoma following vitrectomy: A Systematic Review. Retina. 2017 Apr 19.

6              Menchini F, Toneatto G, Miele A, Donati S, Lanzetta P, Virgili G. Antibiotic prophylaxis for preventing endophthalmitis after intravitreal injection: a systematic review. Eye (Lond). 2018 Sep;32(9):1423-1431.

Systematic review of a animal studies

1. Moja L, Pecoraro V, Ciccolallo L, Dall'Olmo L, Virgili G, Garattini S. Flaws, in animal studies exploring statins and impact on meta-analysis. Eur J Clin Invest. 2014;44(6):597-612.

Other relevant research

Primary diagnostic studies in general medicine

1. Vultaggio A, Matucci A, Virgili G, Rossi O, Filı L, Parronchi P, Romagnani S, Maggi E. Influence of total serum IgE levels on the in vitro detection of b-lactams-specific IgE antibodies. Clinical & Experimental Allergy, 1–7 doi: 10.1111/j.1365-2222.2009.03219.
2. Colagrande S, Pasquinelli F, Mazzoni ML, Belli G, Virgili G. MR-DwI of healthy liver parenchyma: repeatability and reproducibility of apparent diffusion coefficient (ADC) measurement.
3. Matucci A, Pratesi S, Petroni G, Nencini F, Virgili G, Milla M, Maggi E, Vultaggio A. Allergological in vitro and in vivo evaluation of patients with hypersensitivity reactions to infliximab. Clin Exp Allergy. 2013 Jun;43(6):659-64. doi: 10.1111/cea.12098. PubMed PMID: 23711128.
4. Cappellini I, Picciafuochi F, Bartolucci M, Matteini S, Virgili G, Adembri C.  Evaluation of diaphragm thickening by diaphragm ultrasonography: a reproducibility and a repeatability study. J Ultrasound. 2020 May 1.
5. Vultaggio, Alessandra, Emanuele Vivarelli, Gianni Virgili, Ersilia Lucenteforte, Alessandro Bartoloni, Carlo Nozzoli, Alessandro Morettini, et al. “Prompt Predicting of Early Clinical Deterioration of Moderate-to-Severe COVID-19  Patients: Usefulness of a Combined Score Using IL-6 in a Preliminary Study.” The Journal of Allergy and Clinical Immunology. In Practice, June 2020. https://doi.org/10.1016/j.jaip.2020.06.013.
6. Joints. 2017 Jul 28;5(2):125-126. doi: 10.1055/s-0037-1603671. PMID: 29114643; PMCID: PMC5672864.

Epidemiology, public and global health

1. Piyasena P, Olvera-Herrera VO, Chan VF, Clarke M, Wright DM, MacKenzie G, Virgili G, Congdon N. Vision impairment and traffic safety outcomes in low-income and middle-income countries: a systematic review and meta-analysis. Lancet Glob Health. 2021 Oct;9(10):e1411-e1422. doi: 10.1016/S2214-109X(21)00303-X. Epub 2021 Aug 16. PMID: 34411516.
2. Virgili G, Gatta G, Ciccolallo L, Capocaccia R, Biggeri A, Crocetti E, Lutz JM, Paci E; EUROCARE Working Group.  Survival from Uveal Melanoma in Europe. Archives of Ophthalmology 2008 Oct;126(10):1413-8.
3. Virgili G, Gatta G, Ciccolallo L, Capocaccia R, Biggeri A, Crocetti E, Lutz JM, Paci E; EUROCARE Working Group. Incidence of Uveal Melanoma in Europe. Ophthalmology 2007;114:2309–2315.
4. Virgili G, Angi M, Molinari A, Casotto V. Cox regression was used to compare the measurement error of two tests vs. a gold standard. J Clin Epidemiol. 2007 Apr;60(4):345-9.
5. Virgili G, Angi M, Heede S, Rodriguez D, Bottega E, Molinari A. PowerRefractor versus Canon R-50 Autorefraction to assess refractive error in children: a community-based study in Ecuador. Optom Vis Sci. 2007 Feb;84(2):144-8.
6. Saint S, Bartoloni A, Virgili G, Mannelli F, Fumagalli S, di Martino P, Conti AA, Kaufman SR, Gensini GF, Conti A. Marked variability in adherence to hand hygiene: A 5-unit observational study in  Tuscany. Am J Infect Control. 2009 Jan 8.
7. Saint S, Conti A, Bartoloni A, Virgili G, Mannelli F, Fumagalli S, di Martino P, Conti AA, Kaufman SR, Rogers MAM, Gensini GF. Improving healthcare worker hand hygiene adherence before patient contact: a before-and-after five-unit multimodal intervention in Tuscany
8. Virgili G, Barchielli A, Balzi D, Matarrese D, Paci E, Gusinu R, Zuppiroli A, Gensini GF. [Mortality after myocardial infarction: when the health local organization network has a role in interpreting the markers of the National Agency for Regional Health Services]. Epidemiol Prev. 2013 Mar-Jun;37(2-3):176-9.
9. Mavi S, Chan VF, Virgili G, Biagini I, Congdon N, Piyasena P, Yong AC, Ciner EB, Kulp MT, Candy TR, Collins M, Bastawrous A, Morjaria P, Watts E, Masiwa LE, Kumora C, Moore B, Little JA. The Impact of Hyperopia on Academic Performance Among Children: A Systematic Review. Asia Pac J Ophthalmol (Phila). 2022 Jan 20. doi: 10.1097/APO.0000000000000492. Epub ahead of print.  

Pharmacoepidemiology studies and studies using electronic data

1. Virgili G, Barchielli A, Balzi D, Matarrese D, Paci E, Gusinu R, Zuppiroli A, Gensini GF. [Mortality after myocardial infarction: when the health local organization network has a role in interpreting the markers of the National Agency for Regional Health Services]. Epidemiol Prev. 2013 Mar-Jun;37(2-3):176-9.
2. Giuseppe Roberto (ARS), Francesco Attanasio (UniFi) Gianni Virgili (UniFi), Rosa Gini (ARS), Claudio Marinai (ESTAR). Pattern of use of intravitreal drugs with antiangiogenic properties for age-related macular degeneration and other vascular retinopathies. Available at the Tuscany Regional Health Agency at https://www.ars.toscana.it/files/progetti/farmacoepidemiologia/report_antiVEGF.pdf
3. Virgili G, Tosi GM, Figus M, Rizzo S, Murro V, Mucciolo DP, Roberto G, Gini R. Use of anti-vascular endothelial growth factor drugs for eye disease in Tuscany:  Development and test of indicators of treatment intensity. Eur J Ophthalmol. 2019 Oct 30:1120672119885045.
4. Scondotto G, Sultana J, Ientile V, Ingrasciotta Y, Fontana A, Copetti M, Mirabelli E, Trombetta CJ, Rapisarda C, Reibaldi M, Avitabile T, Longo A, Toro PI, Vadalà M, Cillino S, Virgili G, Gini R, Leoni O, Pollina Addario SW, Cananzi  P, La Cavera C, Puzo MR, De Sarro G, De Francesco A, Trifirò G. How Have Intravitreal Anti-VEGF and Dexamethasone Implant Been Used in Italy? A Multiregional, Population-Based Study in the Years 2010-2016. Biomed Res Int. 2020 Jan 11;2020:7582763.
5. Scondotto G, Crisafulli S, Antonazzo IC, Virgili G, Trifirò G, Sultana J. Assessing intravitreal anti-VEGF drug safety using real-world data: methodological challenges in observational research. Expert Opin Drug Saf. 2021 Jul 27:1-10. doi: 10.1080/14740338.2021.1957829. Epub ahead of print. PMID: 34304672.

I authorize the use of my personal data according to regulation D.Lgs. 196/2003 and UE 2016/679