Esperienze lavorative

Istruzione

Pubblicazioni scelte

-        F. Piazza, The physics of boundary conditions in reaction-diffusion systems, Journal of Chemical Physics, 157, 234110 (2022)

-        D. M. Busiello, S. Liang, F. Piazza and P. De Los Rios,  Dissipation-driven selection of states in non-equilibrium chemical networks Communications Chemistry 4 16 (2021)

-        R. Nehme, R. Nasreddine, L. Orlic, C. Lopin-Bon, J. Hamacek, Francesco Piazza, Kinetic theory of hyaluronan cleavage by bovine testicular hyaluronidase in standard and crowded environments, Biochimica et Biophysica Acta (BBA) - General Subjects 1865(3) 129837 (2021)

-        S. Saurabh and F. Piazza, Mesoscale computational protocols for the design of highly cooperative bivalent macromolecules. Scientific Reports 10 Article number: 7992(2020)

-        A. Sozza, F. Piazza, M. Cencini, F. De Lillo, G. Boffetta, Point-particle method to compute diffusion-limited cellular uptake. Physical Review E - 97 023301 (2018)

-        S. Pouyandeh, S. Iubini, S. Jurinovich, Y. Omar, B. Mennucci, F. Piazza. Exciton transport in the PE545 complex: insight from atomistic QM/MM-based quantum master equations and elastic network models. Physical Biology - 14 066001 (2017)

-        C. De Michele, P. De Los Rios, G. Foffi and F. Piazza. Simulation and Theory of Antibody Binding to Crowded Antigen-Covered Surfaces. Plos Comp. Biol. - 12(3), e1004752-- (2016)

-        F. Piazza, P. De Los Rios and F. Cecconi, Temperature dependence of normal mode reconstructions of protein dynamics. Physical Review Letters - 102, 218104 (2009)

-        F. Cecconi, P. De Los Rios and F. Piazza, Diffusion-limited unbinding of small peptides from PDZ domains. J. Phys. Chem. B - 111, 11057-11063 (2007)

-        C. Caretta-Cartozo, P. De Los Rios, F. Piazza and P. Lio, Topological analysis of a network of periodic genes in the cell-cycle of Schizosaccharomyces Pombe. PLoS Computational Biology - 3 (6), e103 (2007)

Progetti finanziati scelti

-        2021 – CNRS, International Emerging Actions (IEA).  Coupling between self-generated gradients and environment topology in tumor invasion: towards understanding the microscopic basis of cell decision processes in chemotaxis and durotaxis. 7 k€ over 3 years. Mobility and consumables.  Project coordinator.

-        2021 – ANR collaborative projects. Enzymatic Remodeling of the Extracellular Matrix: Experiments in Synthetic Crowded Mimics to Build Comprehensive Kinetic Models, 559 k€, over 4 years. Project coordinator

-        2021 – Bispecific di-affibodies for cancer immunotherapy, Ligue contre le cancer (CBM, 20 k€), co-PI.

-        2021 – Collaborative project Fédération de Recherche "Physique et Chimie du Vivant (ICOA Orléans), "Synthesis of hyaluronic acid oligosaccharides and analogues and the study of the mechanism of action of hyaluronidase" (M2 trainee), co-PI.

-        2021 – Collaborative project RTR MOTIVHEALTH, Mechanism of hyaluronidase inhibition in model artificial media and in the extracellular matrix (funding for an M2 trainee), co-PI.

-        2018 – Multi-specific polytopic assemblies for cancer immunotherapy and imaging, Ligue contre le cancer  (25 k€), co-PI.

-        2018 – Physical and computational aided design of bispecific antibodies for cancer immunotherapy (ComPhysAb), INSERM Physics of cancer. Principal investigator of the Orléans node (140 kEUR), co-PI.  

-        2018 PIA2 (Programme Investissements d'Avenir, French Ministry of Education). Project BIOS in collaboration with the University of Tours, INRA Nouzilly and the SERVIER laboratory. 130 kEUR, Principal investigator of the CBM node. 

-        2017 – Multi-specific agents for cancer immunotherapy and imaging: in silico design, assembly and testing, Cancéropole Grand Ouest  (€17,500, Emergence call for tenders), co-PI.

Responsabilità di ricerca, insegnamento e supervisione 

Organizzazione di workshop e conferenze internazionali

-        Co-organized the CECAM workshop “Liquid, soft, alive: identifying the biological questions in the physics of cells”, February 13, 2023 - February 16, 2023, CECAM-HQ-EPFL, Lausanne, Switzerland. Web site: https://www.cecam.org/workshop-details/1129

-        Co-organized the workshop Workshop on New Frontiers in Molecular Crowding, ESRF, Grenoble, (FR), 29/06 -01/07 2022.

Web site: https://www.esrf.fr/home/events/conferences/2022/new-frontiers-in-molecular-crowding.html

-        Co-organized the International Conference “Recent advances in basic and applied science in cosmetics”, held from July 3rd to July 5th 2017 in Tours, France. http://www.lestudium-ias.com/fr/event/recent-advances-basic-and-applied-science- cosmetics 

-        Co-organized the third edition of the series of international conferences “Reaction Kinetics in Soft and Condensed Matter” (RKSCM 2014), held from 1st to 4th july 2014 at the Hotel Dupanloup (International Centre for Research of the University of Orléans), Orléans, France. Web site: http://dirac.cnrs-orleans.fr/~piazza/RKCM2014/

-        Co-organized the international workshop “Macromolecular crowding effects in cell biology: models and experiments”, held from 24th to 25th October 2013, CNRS campus, Orléans, France.

-        Co-organized the international conference “Macromolecular crowding: chemistry and physics meet biology”, held from 10th to 14th june 2012 at the Centro S. Franscini, Monte Verità, Ascona, Switzerland. Web site: http://crowding2012.epfl.ch

-        Served as guest editor for a special (focus) issue of the IOP journal Physical Biology devoted to the conference Molecular Crowding 2012. Web site:http://iopscience.iop.org/1478-3975/10/4

Inviti scelti a conferenze internazionali

-        31st May 2023, “Dall’eno-fisica all’ontologia della percezione sensoriale (e ritorno, forse). Arcetri, Workshop di sistemi complessi in onore dei 70 anni di Roberto Livi (invited seminar)

-        23rd June 2022, “Physical Chemistry of Crowded Media: From in-vitro to living systems”. RBPGO 9, Les 9ièmes Rencontres de Biologie-Physique du Grand-Ouest 2022 (invited lecture).

-        7th February 2020, “Crowding-Induced Uncompetitive Inhibition of enzyme kinetics: Entropic Pushing”, 6th workshop “Physics of biomolecules: structure, dynamics and function”, Bressanone, Italy (invited seminar).

-        16th November 2019, “Non-equilibrium effects in life sciences and nano-biotechnology”, X Workshop in Complexity of Water and Other Liquids, UFPEL, Pelotas, Brazil (invited talk).

-        21st November 2019, “Diffusion of small ligands in complex confining and reactive landscapes: the geometry of chemoreception”, Department of Physics, UFPEL, Pelotas, Brazil (invited lecture).

-        28th October 2019, “Complex systems and statistical physics methods in life sciences and nano-biotechnology”, Università dell’Insubria, Dipartimento di Fisica (invited seminar).

-        12th September 2019, “Complex systems and statistical physics methods in life sciences and nano-biotechnology”, Università di Firenze, Dipartimento di Fisica (invited seminar).

-        18th December 2018, “Ultra-coarse-grained models to simulate ligand-receptor kinetics of complex multivalent molecules”, Laboratoire Adhésion & Inflammation (LAI), Université Aix-Marseille (invited seminar).

-        13th October 2018, “Non-equilibrium chemical kinetics: insight into prebiotic chemistry”, 2018 international workshop on complexity in engineering (COMPENG 2018), Florence, Italy (contributed talk).

-        12th September 2018, “Coarse-grained elastic and nonlinear network models of proteins: surprises from the high-frequency end”, CECAM workshop on “Normal modes of biological macromolecules: methods and applications”, Paris (invited talk).

-        24th April 2018, “Transient localization of gap modes in NaI crystals at high temperature: insight and questions from wavelet analysis”, VI International Symposium on Strong Nonlinear Vibronic and Electronic Interactions in Solids, Tartu, Estonia (invited seminar).

Work experience

Education and training

Selected publications

-        F. Piazza, The physics of boundary conditions in reaction-diffusion systems, Journal of Chemical Physics, 157, 234110 (2022)

-        D. M. Busiello, S. Liang, F. Piazza and P. De Los Rios,  Dissipation-driven selection of states in non-equilibrium chemical networks Communications Chemistry 4 16 (2021)

-        R. Nehme, R. Nasreddine, L. Orlic, C. Lopin-Bon, J. Hamacek, Francesco Piazza, Kinetic theory of hyaluronan cleavage by bovine testicular hyaluronidase in standard and crowded environments, Biochimica et Biophysica Acta (BBA) - General Subjects 1865(3) 129837 (2021)

-        S. Saurabh and F. Piazza, Mesoscale computational protocols for the design of highly cooperative bivalent macromolecules. Scientific Reports 10 Article number: 7992(2020)

-        A. Sozza, F. Piazza, M. Cencini, F. De Lillo, G. Boffetta, Point-particle method to compute diffusion-limited cellular uptake. Physical Review E - 97 023301 (2018)

-        S. Pouyandeh, S. Iubini, S. Jurinovich, Y. Omar, B. Mennucci, F. Piazza. Exciton transport in the PE545 complex: insight from atomistic QM/MM-based quantum master equations and elastic network models. Physical Biology - 14 066001 (2017)

-        C. De Michele, P. De Los Rios, G. Foffi and F. Piazza. Simulation and Theory of Antibody Binding to Crowded Antigen-Covered Surfaces. Plos Comp. Biol. - 12(3), e1004752-- (2016)

-        F. Piazza, P. De Los Rios and F. Cecconi, Temperature dependence of normal mode reconstructions of protein dynamics. Physical Review Letters - 102, 218104 (2009)

-        F. Cecconi, P. De Los Rios and F. Piazza, Diffusion-limited unbinding of small peptides from PDZ domains. J. Phys. Chem. B - 111, 11057-11063 (2007)

-        C. Caretta-Cartozo, P. De Los Rios, F. Piazza and P. Lio, Topological analysis of a network of periodic genes in the cell-cycle of Schizosaccharomyces Pombe. PLoS Computational Biology - 3 (6), e103 (2007)

Selected funded projects

-        2021 – CNRS, International Emerging Actions (IEA).  Coupling between self-generated gradients and environment topology in tumor invasion: towards understanding the microscopic basis of cell decision processes in chemotaxis and durotaxis. 7 k€ over 3 years. Mobility and consumables.  Project coordinator.

-        2021 – ANR collaborative projects. Enzymatic Remodeling of the Extracellular Matrix: Experiments in Synthetic Crowded Mimics to Build Comprehensive Kinetic Models, 559 k€, over 4 years. Project coordinator

-        2021 – Bispecific di-affibodies for cancer immunotherapy, Ligue contre le cancer (CBM, 20 k€), co-PI.

-        2021 – Collaborative project Fédération de Recherche "Physique et Chimie du Vivant (ICOA Orléans), "Synthesis of hyaluronic acid oligosaccharides and analogues and the study of the mechanism of action of hyaluronidase" (M2 trainee), co-PI.

-        2021 – Collaborative project RTR MOTIVHEALTH, Mechanism of hyaluronidase inhibition in model artificial media and in the extracellular matrix (funding for an M2 trainee), co-PI.

-        2018 – Multi-specific polytopic assemblies for cancer immunotherapy and imaging, Ligue contre le cancer  (25 k€), co-PI.

-        2018 – Physical and computational aided design of bispecific antibodies for cancer immunotherapy (ComPhysAb), INSERM Physics of cancer. Principal investigator of the Orléans node (140 kEUR), co-PI.  

-        2018 PIA2 (Programme Investissements d'Avenir, French Ministry of Education). Project BIOS in collaboration with the University of Tours, INRA Nouzilly and the SERVIER laboratory. 130 kEUR, Principal investigator of the CBM node. 

-        2017 – Multi-specific agents for cancer immunotherapy and imaging: in silico design, assembly and testing, Cancéropole Grand Ouest  (€17,500, Emergence call for tenders), co-PI.

Research, teaching responsibilities and supervision

Organization of international workshops and conferences

-        Co-organized the CECAM workshop “Liquid, soft, alive: identifying the biological questions in the physics of cells”, February 13, 2023 - February 16, 2023, CECAM-HQ-EPFL, Lausanne, Switzerland. Web site: https://www.cecam.org/workshop-details/1129

-        Co-organized the workshop Workshop on New Frontiers in Molecular Crowding, ESRF, Grenoble, (FR), 29/06 -01/07 2022.

Web site: https://www.esrf.fr/home/events/conferences/2022/new-frontiers-in-molecular-crowding.html

-        Co-organized the International Conference “Recent advances in basic and applied science in cosmetics”, held from July 3rd to July 5th 2017 in Tours, France. http://www.lestudium-ias.com/fr/event/recent-advances-basic-and-applied-science- cosmetics 

-        Co-organized the third edition of the series of international conferences “Reaction Kinetics in Soft and Condensed Matter” (RKSCM 2014), held from 1st to 4th july 2014 at the Hotel Dupanloup (International Centre for Research of the University of Orléans), Orléans, France. Web site: http://dirac.cnrs-orleans.fr/~piazza/RKCM2014/

-        Co-organized the international workshop “Macromolecular crowding effects in cell biology: models and experiments”, held from 24th to 25th October 2013, CNRS campus, Orléans, France.

-        Co-organized the international conference “Macromolecular crowding: chemistry and physics meet biology”, held from 10th to 14th june 2012 at the Centro S. Franscini, Monte Verità, Ascona, Switzerland. Web site: http://crowding2012.epfl.ch

-        Served as guest editor for a special (focus) issue of the IOP journal Physical Biology devoted to the conference Molecular Crowding 2012. Web site:http://iopscience.iop.org/1478-3975/10/4

Selected recent invited communications at national and international conferences 

-        31st May 2023, “Dall’eno-fisica all’ontologia della percezione sensoriale (e ritorno, forse). Arcetri, Workshop di sistemi complessi in onore dei 70 anni di Roberto Livi (invited seminar)

-        23rd June 2022, “Physical Chemistry of Crowded Media: From in-vitro to living systems”. RBPGO 9, Les 9ièmes Rencontres de Biologie-Physique du Grand-Ouest 2022 (invited lecture).

-        7th February 2020, “Crowding-Induced Uncompetitive Inhibition of enzyme kinetics: Entropic Pushing”, 6th workshop “Physics of biomolecules: structure, dynamics and function”, Bressanone, Italy (invited seminar).

-        16th November 2019, “Non-equilibrium effects in life sciences and nano-biotechnology”, X Workshop in Complexity of Water and Other Liquids, UFPEL, Pelotas, Brazil (invited talk).

-        21st November 2019, “Diffusion of small ligands in complex confining and reactive landscapes: the geometry of chemoreception”, Department of Physics, UFPEL, Pelotas, Brazil (invited lecture).

-        28th October 2019, “Complex systems and statistical physics methods in life sciences and nano-biotechnology”, Università dell’Insubria, Dipartimento di Fisica (invited seminar).

-        12th September 2019, “Complex systems and statistical physics methods in life sciences and nano-biotechnology”, Università di Firenze, Dipartimento di Fisica (invited seminar).

-        18th December 2018, “Ultra-coarse-grained models to simulate ligand-receptor kinetics of complex multivalent molecules”, Laboratoire Adhésion & Inflammation (LAI), Université Aix-Marseille (invited seminar).

-        13th October 2018, “Non-equilibrium chemical kinetics: insight into prebiotic chemistry”, 2018 international workshop on complexity in engineering (COMPENG 2018), Florence, Italy (contributed talk).

-        12th September 2018, “Coarse-grained elastic and nonlinear network models of proteins: surprises from the high-frequency end”, CECAM workshop on “Normal modes of biological macromolecules: methods and applications”, Paris (invited talk).

-        24th April 2018, “Transient localization of gap modes in NaI crystals at high temperature: insight and questions from wavelet analysis”, VI International Symposium on Strong Nonlinear Vibronic and Electronic Interactions in Solids, Tartu, Estonia (invited seminar).