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Curriculum

Simone GIANNECCHINI

Ruolo attuale:: Professore Associato
SSD:: MEDS-03/A - Microbiologia e microbiologia clinica
Afferenza organizzativa:: Dipartimento di Medicina Sperimentale e Clinica

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	simone.giannecchini(AT)unifi.it

Simone GIANNECCHINI

Curriculum

Nome: SIMONE Cognome: GIANNECCHINI (Data di nascita: 1.1.1969 Luogo di nascita: Viareggio (Lucca) Nazionalità: Italiana) Posizione ricoperta: Professore Associato del settore SSD MED/07, Università degli Studi di Firenze.

Titoli di studio. Laurea in Scienze Biologiche conseguita il 2.6.1993 con votazione 106/110 all’Università degli Studi di Pisa. Abilitazione all’esercizio della professione di Biologo conseguita nel 1995, presso l’Università degli Studi di Pisa. Dottore di ricerca, in “Immunobiologia dei virus” titolo conseguito il 1.6.1998 presso l’Università degli Studi di Pisa. Master in E-Medicina, titolo conseguito il 17.01.2006 con votazione 110/110 e lode all’Università degli Studi di Firenze Dall’Aprile 2004-2006 ricercatore tempo determinato presso Università degli studi di Firenze. Abilitazione a professore associato nel settore 05/I1 Genetica e Microbiologia anno 2014. Abilitazione a professore associato nel settore 06/A3 Microbiologia e Microbiologia Clinica anno 2017.

Borse di studio, brevetti e premi. Borsa post-dottorato, di durata biennale, presso l’Università degli studi di Pisa Ottobre 1998. Borsa di studio ANLAIDS settore biomedico in memoria “G.B. Rossi” Dicembre 2000. Borsa di studio AIDS bandita dall’Istituto Superiore di Sanità, Dicembre 2002. Inventore del brevetto “Oligopeptidi e loro utilizzo nel trattamento farmacologico dell’infezione da FIV nel gatto”, depositato dalla HIPPOCAMPE S. A. (attuale MYMETICS SA) in Francia il 17 dicembre 2001. Premio scientifico annuale in memoria “G.B. Rossi” per il miglior lavoro su temi AIDS pubblicato nel 2001-2002.

Attività di ricerca. Da circa 25-anni la sua attività scientifica riguarda la biologia cellulare e molecolare applicata allo studio della patogenesi delle infezioni virali e alla loro prevenzione. Il suo principale interesse sono i meccanismi molecolari dell’immunopatogenesi delle infezioni virali e lo sviluppo di antivirali. Argomenti principali: Nell’ambito degli studi su i Poliomavirus: le sue ricerche riguardano lo studio dei meccanismi molecolari virali e dei fattori cellulari dell’ospite che possono essere coinvolti nella riattivazione dei Polyomavirus humani (polyomavirus JC (JCPyV), polyomavirus BK (BKPyV)) in pazienti immunosoppressi (pazienti HIV e pazienti con Sclerosi Multipla sotto trattamento dei farmaci monoclonali tipo Natalizumab) e che possono determinare l’inizio dello sviluppo delle malattie associate a questi polyomavirus (Leucoencefalopatia multifocale Progressiva, Nefropatia Polyomavirus associata). In particolare gli studi sono rivolti alla identificazione del ruolo dei microRNA virali presenti negli esosomi che si trovano in circolo nei fluidi biologici nella persistenza virale e nella riattivazione e induzione della malattia in condizioni di immunodepressione. Questi studi hanno previsto collaborazioni con responsabili scientifici di esperienza nazionale/internazionale dell’Università di Milano. Nell’ambito dei virus dell’Influenza: studio genetico della trasmissione interspecie di virus dell’influenza aviari per identificare possibili marcatori molecolari implicati nella trasmissione/patogenicità dei virus aviari. Inoltre, i suoi studi hanno riguardato lo sviluppo di nuovi farmaci anti-virus dell’influenza basati su acidi nucleici disegnati sulle sequenze di packaging genomiche virali per l’allestimento di terapie innovative. Questi studi hanno previsto collaborazioni con responsabili scientifici di esperienza nazionale/internazionale dell’Università di Padova, Istituto Zooprofilattico delle Venezie, Istituto Superiore di Sanità. Nell’ambito di virus emergenti: studio come responsabile di unità operativa in progetti che prevedono lo sviluppo di nuovi farmaci universali per il trattamento di Arbovirus. Nell’ambito dei Lentivirus: studio dei meccanismi di neutralizzazione e di patogenesi dei lentivirus utilizzando il modello del virus dell’immunodeficienza felina (FIV). Sviluppo di nuovi antivirali basati sulle sequenze della proteina di fusione per lo sviluppo di farmaci inibitori della fusione virale come modello per sviluppare terapie per HIV. Questi studi hanno previsto collaborazioni con esperti internazionali nel campo della ricerca di modelli animali per AIDS.

Attività di sorveglianza Virologica dell’influenza nel periodo epidemico e pandemico. Dal 2004 al 2015 ha partecipato come collaboratore. Recentemente è diventato responsabile. Isolamento su MDCK e tipizzazione molecolare dei campioni clinici virali influenzali raccolti dai medici sentinella facenti parte del circuito toscano per il monitoraggio dei virus influenzali ed inviati al centro di riferimento regionale (Dipartimento Medicina Sperimentale e Clinica, lab. Virologia). Successivo invio dei risultati e dei medesimi campioni al centro di riferimento nazionale dell’Istituto Superiore di Sanità, Roma.

Collaboratore Universitario Attività assistenziale presso unità operativa diagnostica di Microbiologia e Virologia dell’azienda Ospedaliera-Universitaria di Careggi: diagnostica molecolare dei virus influenzali, monitoraggio dell’infezione da Polyomavirus JC e monitoraggio dell’infezioni da Arbovirus (Zika e West Nile virus). Implementazione e sviluppo metodiche molecolari di supporto alla diagnostica.

Partecipazione al corpo docenti del Dottorato di Scienze Cliniche, Università di Firenze. Socio delle società: Società Italiana di Microbiologia (SIM); Società Italiana di Virologia (SIV-ISV); Società Europea di Virologia (ESV). Editor del World Journal of Virology, peer-reviewed online open-access journal of virology (2011-2018).

Simone GIANNECCHINI

Pubblicazioni

Legenda

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Tesi di Dottorato

Diego Fiorucci, Micaela Meaccini, Giulio Poli1, Maria Alfreda Stincarelli, Chiara Vagaggini1, Simone Giannecchini, Priscila Sutto-Ortiz3, Bruno Canard, Etienne Decroly3, Elena Dreassi, Annalaura Brai, Maurizio Botta (2024). Identification of Novel Non-Nucleoside Inhibitors of Zika Virus NS5 Protein Targeting MTase Activity. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 25, pp. 1-15, ISSN:1422-0067 DOI

Quagliata, M.; Stincarelli, M.A.; Di Santo, A.; Pacini, L.; Real-Fernandez, F.; Arvia, R.; Rinaldi, S.; Giannecchini, S.; Papini, A.M.; Rovero, P. (2024). Synthesis, conformational analysis and biological activity evaluation of novel antiviral peptides blocking the SARS-CoV-2 cell-entry. In: 37th European Peptide Symposium, The European Peptide Society, pp. 2080-2080. DOI

Ferreira de Oliveira Neto N, Velôso Caixeta RA, Zerbinati RM, Zarpellon AC, CaetanoMW, Pallos D, Junges R, Ferreira Costa AL, Aitken-Saavedra J, Giannecchini S, Braz da Silva PH. (2024). The Emergence of Saliva as a Diagnostic and Prognostic Tool for Viral Infections. VIRUSES, vol. 16, pp. 1-18, ISSN:1999-4915

Caixeta RAV, Batista AM, Caetano MW, Palmieri M, Schwab G, Zerbinati RM, Victor ASP, Gallo CB, Tozetto-Mendoza TR, Junges R, Ortega KL, Costa ALF, Sarmento DJS, Pallos D, Lindoso JAL, Giannecchini S, Braz-Silva PH. (2024). Investigation of Oral Shedding of Torquetenovirus (TTV) in Moderate-to-Severe COVID-19 Hospitalised Patients. VIRUSES, vol. 16, pp. 1-11, ISSN:1999-4915

Maria Alfreda Stincarelli, Michael Quagliata, Andrea Di Santo, Lorenzo Pacini, Feliciana Real Fernandez, Rosaria Arvia, Silvia Rinaldi, Anna Maria Papini, Paolo Rovero, Simone Giannecchini (2023). SARS-CoV-2 inhibitory activity of a short peptide derived from internal fusion peptide of S2 subunit of spike glycoprotein. VIRUS RESEARCH, vol. 334, pp. 1-11, ISSN:0168-1702

Michael Quagliata, Maria Alfreda Stincarelli, Anna Maria Papini, Simone Giannecchini, Paolo Rovero (2023). Antiviral activity against SARS-CoV-2 of conformationally constrained helical peptides derived from angiotensin-converting enzyme-2.. ACS OMEGA, vol. 8, pp. 22665-22672, ISSN:2470-1343 DOI Accesso ONLINE all'editore

Tania Regina Tozetto-Mendoza; Paulo Henrique Braz-Silva; Simone Giannecchini; Steven S. Witkin; (2023). Editorial: Torquetenovirus: predictive biomarker or innocent bystander in pathogenesis. FRONTIERS IN MEDICINE, vol. 10, pp. 1-2, ISSN:2296-858X

Maria Alfreda Stincarelli, Rosaria Arvia, Simone Giannecchini (2023). Extracellular vesicles engagement during respiratory viruses infection. ASPECTS OF MOLECULAR MEDICINE, vol. 1, pp. 1-10, ISSN:2949-6888

Thayna Martins Gonçalves, Patrícia Mitsue Saruhashi Shimabukuro, Karen Renata Nakamura Hiraki, Paulo Henrique Braz-Silva, Simone Giannecchini, Kelvin Kai-Wang To, Monica Taminato, Richarlisson Borges de Morais (2023). Severe acute respiratory syndrome by influenza and factors associated with death in older adults: a population study: Factors associated with death due to influenza. JOURNAL OF INFECTION IN DEVELOPING COUNTRIES, vol. 17, pp. 241-250, ISSN:1972-2680

Lazari LC, Zerbinati RM, Rosa-Fernandes L, Santiago VF, Rosa KF, Angeli CB, Schwab G, Palmieri M, Sarmento DJS, Marinho CRF, Almeida JD, To K, Giannecchini S, Wrenger C, Sabino EC, Martinho H, Lindoso JAL, Durigon EL, Braz-Silva PH, Palmisano G. (2022). MALDI-TOF mass spectrometry of saliva samples as a prognostic tool for COVID-19. JOURNAL OF ORAL MICROBIOLOGY, vol. 14, pp. 1-12, ISSN:2000-2297

Stincarelli MA, Baj A, Guidotti B, Spezia PG, Novazzi F, Lucenteforte E, Tillati S, Focosi D, Maggi F, Giannecchini S. (2022). Plasma Torquetenovirus (TTV) microRNAs and severity of COVID-19. VIROLOGY JOURNAL, vol. 19, pp. 1-7, ISSN:1743-422X

Alexandre Mendes Batista, Matheus W Caetano, Maria Stincarelli, Ana C Mamana, Rodrigo Melim Zerbinati, Dmitry J S Sarmento, Marina Gallottini, Rafael A V Caixeta, José Medina-Pestana, Bengt Hasséus, Louise Zanella, Tania R Tozetto-Mendoza, Simone Giannecchini, Paulo H Braz-Silva (2022). Quantification of torque teno virus (TTV) DNA in saliva and plasma samples in patients at short time before and after kidney transplantation. JOURNAL OF ORAL MICROBIOLOGY, vol. 14, pp. 1-8, ISSN:2000-2297

Rodrigo Melim Zerbinati, Palmieri M, Schwab G, Felix AC, Martinho H, Giannecchini S, To K, Lauletta Lindoso JA, Camila Malta Romano, Braz-Silva PH (2022). Use of Saliva and RT-PCR Screening for SARS-CoV-2 Variants of Concern: Surveillance and Monitoring. JOURNAL OF MEDICAL VIROLOGY, vol. 94, pp. 1-4, ISSN:0146-6615

de Morais RB, Shimabukuro PMS, Gonçalves TM, Hiraki KRN, Braz-Silva PH, Giannecchini S, To KKW, Barbosa DA, Taminato M. (2022). Factors associated with death due to severe acute respiratory syndrome caused by influenza: Brazilian population study.. JOURNAL OF INFECTION AND PUBLIC HEALTH, vol. 15, pp. 1388-1393, ISSN:1876-0341 DOI

Schwab G, Palmieri M, Zerbinati RM, Sarmento DJS, Reis T, Ortega KL, Kano IT, Caixeta RAV, Hasséus B, Sapkota D, Junges R, Giannecchini S, Costa ALF, Jales SMCP, Lindoso JAL, Gallo CB, Braz-Silva PH. (2022). Lack of direct association between oral mucosal lesions and SARS-CoV- 2 in a cohort of patients hospitalised with COVID-19. JOURNAL OF ORAL MICROBIOLOGY, vol. 14, pp. 1-10, ISSN:2000-2297

Stincarelli MA, Rocca A, Antonelli A, Rossolini GM, Giannecchini S. (2022). Antiviral activity of oligonucleotides targeting the SARS-CoV-2 genomic RNA stem-loop sequences within the 3’-end of the ORF1b.. PATHOGENS, vol. 11, pp. 1-15, ISSN:2076-0817 DOI

Najar B, Nardi V, Stincarelli MA, Patrissi S, Pistelli L, Giannecchini S. (2021). Screening of the essential oil effects on human H1N1 influenza virus infection: an in vitro study in MDCK cells. NATURAL PRODUCT RESEARCH, vol. 26, pp. 1-4, ISSN:1478-6419

Marchi S, Montomoli E, Viviani S, Giannecchini S, Stincarelli MA, Lanave G, Camero M, Alessio C, Coluccio R, Trombetta CM (2021). West Nile virus seroprevalence in the Italian Tuscany region from 2016 to 2019. PATHOGENESIS, vol. 10, pp. 844-854, ISSN:2214-6636

Mamana AC, Stincarelli M, de Santana Sarmento DJ, Mendes Batista A, Tozetto-Mendoza TR, Gallottini M, Medina de Abreu Pestana JO, Braz-Silva PH, Giannecchini S. (2021). Detection of Polyomavirus microRNA-5p Expression in Saliva Short-Term after Kidney Transplantation. JOURNAL OF ORAL MICROBIOLOGY, vol. 13, pp. 1-8, ISSN:2000-2297

Basma Najar; Giulia Mecacci; Valeria Nardi; Claudio Cervelli; Simona Nardoni; Francesca Mancianti; Valentina Virginia Ebani; Simone Giannecchini; and Luisa Pistelli (2021). Volatiles and Antifungal-Antibacterial-Antiviral Activity of South African Salvia spp. Essential Oils Cultivated in Uniform Conditions. MOLECULES, vol. 13, pp. 1-16, ISSN:1420-3049

Paulo Henrique Braz-Silva, Debora Pallos, Simone Giannecchini, Kelvin Kai-Wang To (2020). SARS-CoV-2: What Can Saliva Tell Us?. ORAL DISEASES, pp. 1-2, ISSN:1601-0825

Stefano Scribano, Mirko Guerrini, Rosaria Arvia, Daniele Guasti, Patrizia Nardini, Paolo Romagnoli, Simone Giannecchini (2020). Archetype JC polyomavirus DNA associated with extracellular vesicles circulates in human plasma samples.. JOURNAL OF CLINICAL VIROLOGY, vol. 128, pp. 1-5, ISSN:1873-5967

Dipak Sapkota, Tine Merete Søland, Hilde Kanli Galtung, Lars Peter Sand, Simone Giannecchini, Kelvin K W To, Maria Cassia Mendes-Correa, Daniel Giglio, Bengt Hasséus , Paulo Henrique Braz-Silva (2020). COVID-19 Salivary Signature: Diagnostic and Research Opportunities. JOURNAL OF CLINICAL PATHOLOGY, vol. 0, pp. 1-6, ISSN:0021-9746 DOI

Neri L, Spezia PG, Suraci S, Macera L, Scribano S, Giusti B, Focosi D, Maggi F, Giannecchini S. (2020). Torque teno virus microRNA detection in cerebrospinal fluids of patients with neurological pathologies. JOURNAL OF CLINICAL VIROLOGY, vol. 133, pp. 1-5, ISSN:1873-5967

Valentina Riva, Anna Garbelli, Annalaura Brai, Federica Casiraghi, Roberta Fazi, Claudia I Trivisani, Adele Boccuto, Francesco Saladini, Ilaria Vicenti, Francesco Martelli, Maurizio Zazzi, Simone Giannecchini, Elena Dreassi, Maurizio Botta, Giovanni Maga (2020). A unique domain for a unique target: selective inhibitors of host cell DDX3X to fight emerging viruses. JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, pp. 9876-9887, ISSN:1520-4804

Paulo H. Braz-Silva, Ana C. Mamana, Camila M. Romano, Alvina C. Felix, Anderson V. de Paula, Noeli E Fereira, Lewis F. Buss, Tania R. Tozetto-Mendoza, Rafael A. V. Caixeta, Fabio E. Leal, Regina M. Z. Grespan, João C. S. Bizário, Andrea B. C. Ferraz, Dipak Sapkotad, Simone Giannecchini, Kelvin K. To, Alain Doglio, Maria C. Mendes-Corre (2020). Performance of at-home self-collected saliva and nasal-oropharyngeal swabs in the surveillance of COVID-19. JOURNAL OF ORAL MICROBIOLOGY, vol. 13, pp. 1-8, ISSN:2000-2297 DOI

Giannecchini s (2020). Evidence of the mechanism by which polyomaviruses exploit the extracellular vesicle delivery system during infection. VIRUSES, vol. 12, pp. 1-17, ISSN:1999-4915

Uleri E, Piu C, Caocci M, Ibba G, Sanges F, Pira G, Murgia L, Barmina M, Giannecchini S, Porcu A, Serra A, Scanu AM, De Miglio MR, Dolei A. (2019). Multiple signatures of the JC polyomavirus in paired normal and altered colorectal mucosa indicate a link with human colorectal cancer, but not with cancer progression.. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 20, pp. 1-15, ISSN:1661-6596

Puzelli S, Di Martino A, Facchini M, Fabiani C, Calzoletti L, Di Mario G, Palmieri A, Affanni P, Camilloni B, Chironna M, D’Agaro P, Giannecchini S, Pariani E, Serra C, Rizzo C, Bella A, Donatelli I, Castrucci MR, Italian Influenza Laboratory Network (2019). Co-circulation of the two influenza B lineages during 13 consecutive influenza surveillance seasons in Italy, 2004-2017. BMC INFECTIOUS DISEASES, vol. 19, pp. 1-11, ISSN:1471-2334 DOI

Bellino S , Bella A, Puzelli S, Di Martino A, Facchini M, Punzo O, Pezzotti P, Castrucci MR, Di Mario G, Calzoletti L. Fabiani C. Chironna M, Germinario C, Tramuto F, Di Carlo V, Affanni P, Pascucci MG, D'Agaro P, Gallo T, Pagani E, Natter B, Camilloni B, Tosti A, Pariani E, Senatore S, Serra C, Tanchis PR, Ghisetti V, Tiberti, D, Romano L, Volpe E, Giannecchini S. (2019). Moderate influenza vaccine effectiveness against A(H1N1)pdm09 virus, and low effectiveness against A(H3N2) subtype, 2018/19 season in Italy. EXPERT REVIEW OF VACCINES, vol. 12, pp. 1-9, ISSN:1744-8395

Brai A, Martelli F, Riva V, Garbelli A, Fazi R, Zamperini C, Pollutri A, Falsitta L, Ronzini S, Maccari L, Maga G, Giannecchini Simone, Botta M. (2019). DDX3X helicase inhibitors as new strategy to fight West Nile Virus infection.. JOURNAL OF MEDICINAL CHEMISTRY, pp. 2333-2347, ISSN:0022-2623

Francesco Martelli, Jessica Mencarini, Arianna Rocca, Nunzia Della Malva, Dario Bartolozzi, Simone Giannecchini (2018). Polyomavirus microRNA in saliva reveals persistent infectious status in the oral cavity. VIRUS RESEARCH, vol. 249, pp. 1-7, ISSN:0168-1702 DOI

Martelli F, Macera L, Spezia PG, Medici C, Pistello M, Guasti D, Romagnoli P, Maggi F, Giannecchini S. (2018). Torquetenovirus detection in exosomes enriched vesicles circulating in human plasma samples.. VIROLOGY JOURNAL, vol. 15, pp. 145-154, ISSN:1743-422X

Martelli F., Wu Z., Delbue S., Weissbach F.,Giulioli M.C., Ferrante P., Hirsch H.H., Giannecchini S. (2018). BK polyomavirus microRNA levels in exosomes are modulated by non-coding control region activity, and down-regulate viral replication when delivered to non-infected cells prior to infection.. VIRUSES, vol. 10, pp. 466-487, ISSN:1999-4915

Giacconi R., Maggi F., Macera L., Pistello M., Provinciali M., Giannecchini S., Martelli F., Spezia P.G., Mariani E., Galeazzi R., Costarelli L., Iovino L., Galimberti S., Nisi L., Piacenza F., Malavolta M. (2018). Torquetenovirus (TTV) load is associated with mortality in Italian elderly subjects. EXPERIMENTAL GERONTOLOGY, vol. 112, pp. 103-111, ISSN:1873-6815

Martelli, Francesco; Giannecchini, Simone (2017). Polyomavirus microRNAs circulating in biological fluids during viral persistence. REVIEWS IN MEDICAL VIROLOGY, vol. 27, pp. 1-13, ISSN:1052-9276 DOI

Vignolini, Tiziano; Macera, Lisa; Antonelli, Guido; Pistello, Mauro; Maggi, Fabrizio; Giannecchini, Simone (2016). Investigation on torquetenovirus (TTV) microRNA transcriptome in vivo. VIRUS RESEARCH, vol. 217, pp. 18-22, ISSN:0168-1702

Giovannelli, I; Clausi, V; Nukuzuma, S; Della Malva, N; Nosi, D; Giannecchini, S (2016). Polyomavirus JC microRNAs expression after infection in vitro.. VIRUS RESEARCH, vol. 213, pp. 269-272, ISSN:0168-1702

Irene, Giovannelli; Nunziata, Ciccone; Guendalina, Vaggelli; Nunzia, Della Malva; Francesca, Torricelli; Gian, Maria Rossolini; Simone, Giannecchini (2016). Utility of droplet digital PCR for the quantitative detection of polyomavirus JC in clinical samples. JOURNAL OF CLINICAL VIROLOGY, vol. 82, pp. 70-75, ISSN:1386-6532

Rocca, Arianna; Martelli, Francesco; Delbue, Serena; Ferrante, Pasquale; Bartolozzi, Dario; Azzi, Alberta; Giannecchini, Simone (2015). The JCPYV DNA load inversely correlates with the viral microrna expression in blood and cerebrospinal fluid of patients at risk of PML. JOURNAL OF CLINICAL VIROLOGY, vol. 70, pp. 1-6, ISSN:1386-6532 DOI Accesso ONLINE all'editore

Martelli, Francesco; Salata, Cristiano; Calistri, Arianna; Parolin, Cristina; Azzi, Alberta; Palù, Giorgio; Giannecchini, Simone (2015). Small RNAs targeting the 5' end of the viral polymerase gene segments specifically interfere with influenza type A virus replication. JOURNAL OF BIOTECHNOLOGY, vol. 210, pp. 85-90, ISSN:0168-1656 DOI Accesso ONLINE all'editore

Clausi, V; Giannecchini, S; Magnani, E; Repice, A; Mechi, C; Martelli, F; Azzi, A; Massacesi, L. (2015). Markers of JC virus infection in patients with multiple sclerosis under natalizumab therapy.. NEUROLOGY® NEUROIMMUNOLOGY & NEUROINFLAMMATION, vol. 2, pp. 1-4, ISSN:2332-7812 DOI Accesso ONLINE all'editore

Giovannelli, I; Martelli, F; Repice, A; Massacesi, L; Azzi, A; Giannecchini, S. (2015). Detection of JCPyV microRNA in blood and urine samples of multiple sclerosis patients under natalizumab therapy.. JOURNAL OF NEUROVIROLOGY, vol. 21, pp. 0-0, ISSN:1355-0284 DOI Accesso ONLINE all'editore

Arianna Rocca; Francesco Martelli; Serena Delbue; Pasquale Ferrante; Dario Bartolozzi; Alberta Azzi; Simone Giannecchini (2014). Preliminary evidence on the use of Polyomavirus JC microRNA as biomarker of viral reactivation. In: 42° congresso nazionale della Società Italiana di Microbiologia, Torino, 28-settembre 1 ottobre, EDIMES, vol. 1, pp. 31-31.

Francesco Martelli; Cristiano Salata; Cristina Parolin; Alberta Azzi; Giorgio Palù; Arianna Calistri; Simone Giannecchini (2014). Development of new antivirals against the influenza type A viruses based on small RNAs targeting the packaging signal of the polymarases gene coding region.. In: 12TH national congress of the Italian Society of Virology (SIV), ORVIETO, 22-24-9-14, SIV, vol. 1, pp. 24-24.

Diotti RA; Mancini N; Clementi N; Sautto G; Moreno GJ; Criscuolo E; Cappelletti F; Man P; Forest E; Remy L; Giannecchini S; Clementi M; Burioni R. (2014). Cloning of the first human anti-JCPyV/VP1 neutralizing monoclonal antibody: epitope definition and implications in risk stratification of patients under natalizumab therapy. ANTIVIRAL RESEARCH, vol. 108, pp. 93-103, ISSN:0166-3542 DOI

Simone Giannecchini ; Irene Giovannelli; Valeria Clausi; Anna Repice; Luca Massacesi; Alberta Azzi (2013). Analisi dell’espressione di microRNA prodotti dal Polyomavirus JC.. In: 41° congresso nazionale della Società Italiana di Microbiologia, Riccione, 16-18 Ottobre 2013, SIM, pp. 97-97.

Simone Giannecchini; Valeria Clausi; Irene Giovannelli; Anna Repice; Luca Massacesi; Alberta Azzi (2013). In vitro and ex vivo detection of human polyomavirus JC microRNA. JOURNAL OF NEUROVIROLOGY, vol. 19, pp. 306-306, ISSN:1355-0284 DOI

Maria Stincarelli; Rosaria Arvia; Maria Alessandra De Marco; Valeria Clausi; Fabiana Corcioli; Claudia Cotti; Mauro Delogu; Isabella Donatelli; Alberta Azzi; Simone Giannecchini (2013). Reassortment ability of the 2009 pandemic H1N1 influenza virus with circulating human and avian influenza viruses: Public health risk implications. VIRUS RESEARCH, vol. 175, pp. 151-154, ISSN:0168-1702 DOI

S.Giannecchini; V.Clausi; A.Vultaggio; L.Macera; F.Maggi; F.Martelli; A.Azzi; E.Maggi; A.Matucci (2012). Assessment of the risk of polyomavirus JC reactivation in patients with immune-mediated diseases during long-term treatment with infliximab. JOURNAL OF NEUROVIROLOGY, vol. 18, pp. 55-61, ISSN:1355-0284 DOI

Simone Giannecchini; Valeria Clausi; Alberta Azzi. (2012). Studio in vitro della capacità di riassortimento del nuovo virus umano dell’influenza A di origine suina H1N1.. In: 37° congresso nazionale della Società Italiana di Microbiologia, SIM, pp. 76-76.

Clausi, V.; Martelli, F.; Repice, A.; Mechi, C.; Magnani, E.; Massacesi, Luca; Azzi, Alberta; Giannecchini, Simone (2012). Detection of polyomavirus JC DNA and anti-JCV antibody in MS patients under natalizumab therapy.. MULTIPLE SCLEROSIS, vol. 18, pp. 467-467, ISSN:1352-4585

Valeria, Clausi; Francesco, Martelli; Anna, Repice; Claudia, Mechi; Eliana, Magnani; Massacesi, Luca; Azzi, Alberta; Giannecchini, Simone (2012). Detection of polyomavirus JC DNA and anti-JCV antibody in MS patients under natalizumab therapy.. MULTIPLE SCLEROSIS, vol. 18, pp. 467-467, ISSN:1352-4585

Stincarelli M.; Clausi; V.; Arvia R.; Corcioli F.; De Marco A; Cotti C.; Delogu M.; Donatelli I.; Azzi A.; Giannecchini S. (2012). Investigation of reassortment ability of pandemic H1N1 influenza virus with circulating human and avian influenza viruses.. In: SIV, pp. 23-23.

Clausi V.; Giannecchini S.; Martelli F.; Matucci A.; Vultaggio A.; Maggi F.; Macera L.; Azzi A. (2011). Polyomavirus JC detection in patients with rheumatic disease after a long-term treatment with infliximab.. In: SIV, pp. 37-37.

Valeria Clausi; Simone Giannecchini; Francesco Martelli; Andrea Matucci; Alessandra Vultaggio; Fabrizio Maggi; Lisa Macera; Alberta Azzi. (2011). Ricerca del Poliomavirus JC in pazienti con malattie reumatiche sottoposti ad un trattamento a lungo termine con infliximab.. In: 39° congresso nazionale della Società Italiana di Microbiologia, SIM, pp. 46-46.

F. Vistoli; D. Focosi; M. De Donno; S. Giannecchini; M.L. Mariotti; M. Occhipinti; M. Barsotti; R. Duquesnoy; P. Marchetti; F. Scatena; U. Boggi (2011). Pancreas rejection after pandemic influenzavirus A(H1N1)vaccination or infection: a report of two cases. TRANSPLANT INTERNATIONAL, vol. 24, pp. 28-29, ISSN:0934-0874 DOI

S. Giannecchini; H.-M. Wise; P. Digard; V. Clausi; E. Del Poggetto; L. Vesco; S. Puzelli; I. Donatelli; A. Azzi (2011). Packaging signals in the 5'-ends of influenza virus PA, PB1, and PB2 genes as potential targets to develop nucleic-acid based antiviral molecules.. ANTIVIRAL RESEARCH, vol. 92, pp. 64-72, ISSN:0166-3542 DOI

F. Vistoli; D. Focosi; M. De Donno; S. Giannecchini; M.L. Mariotti; M. Occhipinti; M. Barsotti; R. Duquesnoy; P. Marchetti; F. Scatena; U. Boggi (2011). Erratum: Pancreas rejection after pandemic influenzavirus A(H1N1) vaccination or infection: A report of two cases (Transplant International (2011) 24 (e28)). TRANSPLANT INTERNATIONAL, vol. 24, pp. 865-865, ISSN:0934-0874 DOI

S. Giannecchini; V. Clausi; L. Di Trani; E. Falcone; C. Terregino; A. Toffan; F. Cilloni; M. Matrosovich; A.S. Gambaryan; N.V. Bovin; M. Delogu; I. Capua; I. Donatelli; A. Azzi. (2010). Molecular adaptation of an H7N3 wild duck influenza virus following experimental multiple passages in quail and turkey.. VIROLOGY, vol. 408, pp. 167-173, ISSN:0042-6822

Giannecchini S.; Clausi V.; Digard P.; Wise H.M.; Del Poggetto E.; Puzelli S.; Donatelli I.; Azzi A. (2010). I segnali di packaging alle estremità 5’ della regione codificante dei geni PA, PB1, E PB2 del virus dell’influenza come potenziali bersagli per lo sviluppo di antivirali.. In: SIM, pp. 37-37.

F. Cilloni; A. Toffan; S. Giannecchini; V. Clausi; A. Azzi; I. Capua; C. Terregino (2010). Increased pathogenicity and shedding in chickens of a wild bird origin LPAI virus of the H7N3 subtype following multiple in vivo passages in quail and turkey.. AVIAN DISEASES, vol. 54, pp. 555-557, ISSN:0005-2086

Giannecchini S.; Clausi V.; Wise H.M.; Digard P.; Del Poggetto E.; Puzelli S.; Donatelli I.; Azzi A. (2010). Packaging signals in the 5' coding region of influenza virus PA, PB1, and PB2 genes as potential target to develop oligonucleotide based antiviral molecole.. In: Antivirals Congress ELSEVIER, pp. 1.14-1.14.

Clausi V.; Corcioli F.; Giannecchini S.; Azzi A (2009). New influenza virus type A (H1N1), isolated in Florence.. In: SIV, pp. 40-40.

S.Giannecchini; V.Clausi; D.Nosi; A.Azzi (2009). Oligonucleotides derived from the packaging signal at the 5’ end of the viral PB2 segment specifically inhibit influenza virus in vitro. ARCHIVES OF VIROLOGY, vol. 154, pp. 821-832, ISSN:0304-8608

Clausi V.; Giannecchini S.; Azzi A. (2009). Development of multiplex RT-PCR specific for the eight genomic segments of avian influenza A H7N3 viruses.. In: SIV, pp. 19-19.

S. GIANNECCHINI; L. CAMPITELLI; G. BANDINI; I. DONATELLI; A. AZZI; (2007). Characterization of human H1N1 influenza virus variants selected In vitro with zanamivir in the presence of sialic acid-containing molecules. VIRUS RESEARCH, vol. 129, pp. 241-245, ISSN:0168-1702

S.Giannecchini; A.M.D'Ursi; C.Esposito; M.Scrima; E.Zabogli; G.Freer; P.Rovero; M.Bendinelli (2007). Antibodies generated in cats by a lipopeptide reproducing the MPER of the feline immunodeficiency virus TM enhance virus infectivity. CLINICAL AND VACCINE IMMUNOLOGY, vol. 14, pp. 944-951, ISSN:1556-679X

S. GIANNECCHINI; CLAUSI V; CAMPITELLI L; DONATELLI I; AND AZZI A (2007). Selezione in vitro di varianti virali di virus dell’ influenza aviaria H7N3 dell’anatra in presenza di sialogangliosidi.. In: SIM, pp. 59-59.

S. GIANNECCHINI; M. PISTELLO; P. ISOLA; D. MATTEUCCI; P. MAZZETTI; G. FREER; M. BENDINELLI (2007). Role of Env in the resistance of feline immunodeficiency virus (FIV)-infected cats to superinfection by a second FIV, as determined using a chimeric virus. JOURNAL OF VIROLOGY, vol. 81, pp. 10474-10485, ISSN:0022-538X, American Society for Microbiology / DC:1752 N Street Northwest:Washington, DC 20036:(202)737-3600, EMAIL: jadelman@asmusa.org, INTERNET: http://www.asmusa.org/asm.htm, Fax: (202)942-9342:

BONCI F; ZABOGLI E; S. GIANNECCHINI; AND BENDINELLI M (2006). Single-round virus replication assay for assisting the design of small molecules inhibiting HIV entry in host cells.. In: SIVIM, pp. 32-32.

GIANNECCHINI S; CAMPITELLI L; CALZOLETTI L; DE MARCO MA; A. AZZI; DONATELLI I (2006). Comparison of in vitro replication features of H7N3 influenza viruses from wild ducks and turkeys: potential implications for interspecies transmission.. JOURNAL OF GENERAL VIROLOGY, vol. 87, pp. 171-175, ISSN:0022-1317, Society for General Microbiology:Marlboro House, Basingstoke Road, Spencers Wood, Reading RG7 1AE United Kingdom:011 44 118 9881814, EMAIL: d.smith@sgm.ac.ukadmin@socgenmicrobiol.org.uk, INTERNET: http://www.sgm.ac.uk, Fax: 011 44 118 9885656:

A.M. DURSI; S. GIANNECCHINI; C. ESPOSITO; M.C. ALCARO; O. SICHI; M.R. ARMENANTE; A. CAROTENUTO; A. PAPINI; M. BENDINELLI; P. ROVERO (2006). Development of antiviral fusion inhibitors: short modified peptides derived from the transmembrane glycoprotein of feline immunodeficiency virus. CHEMBIOCHEM, vol. 7, pp. 774-779, ISSN:1439-4227 DOI

S. GIANNECCHINI; CAMPITELLI L; BANDINI G; DONATELLI I; AND AZZI A (2006). In vitro selection of a human H1N1 influenza virus with zanamivir in presence of sialic acid-containing molecules changes its susceptibility to this inhibitor through substitutions in the neuraminidase and hemagglutinin.. In: SIV, pp. 83-83.

C.ESPOSITO; G.D'ERRICO; M.R.ARMENANTE; S.GIANNECCHINI; M.BENDINELLI; P.ROVERO; A.M.D'URSI (2006). Physicochemical characterization of a peptide deriving from the glycoprotein gp36 of the Feline Immunodeficiency Virus and its lipoylated analogue in micellar systems.. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, vol. 1758, pp. 1653-1661, ISSN:0005-2736 DOI

S. GIANNECCHINI; M. ALCARO; P. ISOLA; O. SICHI; M. PISTELLO; A.M. PAPINI; P. ROVERO; M. BENDINELLI (2005). Feline immunodeficiency virus plasma load reduction by a retroinverso octapeptide reproducing the Trp-rich motif of the transmembrane glycoprotein. ANTIVIRAL THERAPY, vol. 10, pp. 671-680, ISSN:1359-6535 Accesso ONLINE all'editore

BENDINELLI M; MATTEUCCI D; PISTELLO M; FREER G; S. GIANNECCHINI (2005). Are there lessons that can be learned from the FIV model ?. In: Keystone Symposia, pp. 171-171.

S. GIANNECCHINI; CAMPITELLI L; CALZOLETTI L; DE MARCO M. A; AZZI A; DONATELLI I (2005). Investigation of in vitro replication features of wild ducks and turkey H7N3 influenza viruses: possibile role in interspecies transmission.. In: SIV, pp. 46-46.

S. GIANNECCHINI; ALCARO M.C; ISOLA P; SICHI O; PISTELLO M; PAPINI A.M; ROVERO P; BENDINELLI M (2005). A retroinverso peptide reproducing the Trp-rich motif of the FIV TM has favorable pharmacological traits and markedly reduces viral loads in a short-monotherapy experiment.. In: V programma nazionale di ricerca AIDS ISS, pp. 43-43.

M. J. HOSIE; D. KLEIN; J; BINLEY; T.H. DUNSFORD; O. JARRETT; J.C. NEIL; E. KNAPP; S. GIANNECCHINI; D. MATTEUCCI; M. BENDINELLI; J.A. HOXIE AND B.J. WILLETT (2005). Vaccination with an inactivated virulent feline immunodeficiency virus engineered to express high levels of Env. JOURNAL OF VIROLOGY, vol. 79, pp. 1954-1957, ISSN:0022-538X, American Society for Microbiology / DC:1752 N Street Northwest:Washington, DC 20036:(202)737-3600, EMAIL: jadelman@asmusa.org, INTERNET: http://www.asmusa.org/asm.htm, Fax: (202)942-9342:

ZABOGLI E; BONCI F; S. GIANNECCHINI; BASTONE P; MATTEUCCI D; BENDINELLI M; LOCHELT M; PISTELLO M (2005). Foamy virus derived vector as a tool to vaccinate against feline immunodeficiency virus.. In: SIV, pp. 90-90.

S. GIANNECCHINI; F. BONCI; M. PISTELLO; D. MATTEUCCI; O. SICHI; P. ROVERO; AND M. BEDINELLI (2004). The membrane-proximal tryptophan-rich region in the transmembrane glycoprotein ectodomain of feline immunodeficiency virus is important for cell entry.. VIROLOGY, vol. 320, pp. 156-166, ISSN:0042-6822, Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445:

F. MAGGI; E. TEMPESTINI; L. LANINI; E. ANDREOLI; C. FORNAI; S. GIANNECCHINI; M.-L VATTERONI; M. PISTELLO; S. MARCHI; P. CICCOROSSI; S. SPECTER; AND M. BENDINELLI (2004). Blood levels of TT virus following immune stimulation with influenza or hepatitis B vaccine.. JOURNAL OF MEDICAL VIROLOGY, vol. 75, pp. 358-365, ISSN:0146-6615, John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551:

S. GIANNECCHINI; M. PISTELLO; B. DEL SANTO; P. ROVERO; O. SICHI; AND M. BENDINELLI (2004). Changes in the SU can modulate the susceptibility of feline immunodeficiency virus to TM-derived entry inhibitors.. NEW MICROBIOLOGICA, vol. 27, pp. 77-84, ISSN:1121-7138, Tipolitografia l Ponzio:Viale Montegrappa 2, I 27100 Pavia Italy:011 39 0382 576600, Fax: 011 39 0382 574200:

G. FREER; S. GIANNECCHINI; A. TISSOT; M. F. BACHMANN; P. ROVERO; P. F. SERRES; M. BENDINELLI (2004). Dissection of seroreactivity against the tryptophan-rich motif of feline immunodeficiency virus transmembrane glycoprotein.. VIROLOGY, vol. 322, pp. 360-369, ISSN:0042-6822, Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445:

ROVERO P; S. GIANNECCHINI; ESPOSITO C; ALCARO M.C; DURSI A.M; AND BENDINELLI M (2004). Development and in vitro characterization of short modified peptide inhibitors derived from TM gp of FIV for in vivo testing.. In: IFRRS, pp. 51-51.

S. GIANNECCHINI; A. DI FENZA; A. M. DURSI; D. MATTEUCCI; P. ROVERO; AND M. BENDINELLI (2003). Antiviral activity and conformational features of an octapeptide derived from the membrane-proximal ectodomain of the feline immunodeficiency virus transmembrane glycoprotein.. JOURNAL OF VIROLOGY, vol. 77, pp. 3724-3733, ISSN:0022-538X, American Society for Microbiology / DC:1752 N Street Northwest:Washington, DC 20036:(202)737-3600, EMAIL: jadelman@asmusa.org, INTERNET: http://www.asmusa.org/asm.htm, Fax: (202)942-9342: DOI

A. M. DURSI; S. GIANNECCHINI; A. DI FENZA; C. ESPOSITO; A. CAROTENUTO; M. BENDINELLI; P. ROVERO (2003). A retro-inverso analogue of the antiviral octapeptide C8 inhibits feline immunodeficiency virus in serum.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, pp. 1807-1810, ISSN:0022-2623 DOI

M. PISTELLO; D. MATTEUCCI; S. GIANNECCHINI; F. BONCI; O. SICHI; S. PRESCIUTTINI; AND M. BENDINELLI (2003). Evolution of two amino acid positions governing broad neutralization resistence in a strain of feline immunodeficiency virus over 7 years of persistence in cats.. CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, vol. 10, pp. 1109-1116, ISSN:1071-412X, American Society for Microbiology:PO Box 11127:Birmingham, AL 35201:(800)633-4931, (205)995-1567, EMAIL: asm.nonmembers.subs@ebsco.com, INTERNET: http://www.asm.org, Fax: (205)995-1588:

S. GIANNECCHINI; P. ISOLA; O. SICHI; D. MATTEUCCI; M. PISTELLO; L. ZACCARO; D. DEL MAURO; AND M. BENDINELLI (2002). AIDS vaccination studies using an ex vivo feline immunodeficiency virus model: failure to protect and possible enhancement of challenge infection by four cell-based vaccines prepared with autologous lymphoblasts.. JOURNAL OF VIROLOGY, vol. 76, pp. 6882-6892, ISSN:0022-538X, American Society for Microbiology / DC:1752 N Street Northwest:Washington, DC 20036:(202)737-3600, EMAIL: jadelman@asmusa.org, INTERNET: http://www.asmusa.org/asm.htm, Fax: (202)942-9342:

M. BENDINELLI; M. PISTELLO; D. DEL MAURO; G. CAMMAROTA; F. MAGGI; A. LEONILDI; S. GIANNECCHINI; C. BERGAMINI; AND D. MATTEUCCI (2001). During readaptation in vivo, a tissue culture-adapted strain of feline immunodeficiency virus reverts to broad neutralization resistance at different times in individual hosts but through changes at the same position of the surface glycoprotein.. JOURNAL OF VIROLOGY, vol. 75, pp. 4584-4593, ISSN:0022-538X, American Society for Microbiology / DC:1752 N Street Northwest:Washington, DC 20036:(202)737-3600, EMAIL: jadelman@asmusa.org, INTERNET: http://www.asmusa.org/asm.htm, Fax: (202)942-9342:

S. GIANNECCHINI; D. MATTEUCCI; A. FERRARI; M. PISTELLO; AND M. BENDINELLI (2001). Feline immunodeficiency virus-infected cat sera associated with the development of broad neutralization resistance in vivo drive similar reversions in vitro.. JOURNAL OF VIROLOGY, vol. 75, pp. 8868-8873, ISSN:0022-538X, American Society for Microbiology / DC:1752 N Street Northwest:Washington, DC 20036:(202)737-3600, EMAIL: jadelman@asmusa.org, INTERNET: http://www.asmusa.org/asm.htm, Fax: (202)942-9342:

S. GIANNECCHINI; D. DEL MAURO; D. MATTEUCCI; AND M. BENDINELLI (2001). AIDS vaccination studies using an ex vivo feline immunodeficiency virus model: reevaluation of neutralizing antibody levels elicited by a protective and a nonprotective vaccine after removal of antisubstrate cell antibodies.. JOURNAL OF VIROLOGY, vol. 75, pp. 4424-4429, ISSN:0022-538X, American Society for Microbiology / DC:1752 N Street Northwest:Washington, DC 20036:(202)737-3600, EMAIL: jadelman@asmusa.org, INTERNET: http://www.asmusa.org/asm.htm, Fax: (202)942-9342:

D. MATTEUCCI; A. POLI; P. MAZZETTI; S. SOZZI; F. BONCI; P. ISOLA; L. ZACCARO; S. GIANNECCHINI; M. CALANDRELLA; M. PISTELLO; S. SPECTER; AND M. BENDINELLI (2000). Immunogenicity of an anti-clade B feline immunodeficiency fixed-cell virus vaccine in field cats.. JOURNAL OF VIROLOGY, vol. 74, pp. 10911-10919, ISSN:0022-538X, American Society for Microbiology / DC:1752 N Street Northwest:Washington, DC 20036:(202)737-3600, EMAIL: jadelman@asmusa.org, INTERNET: http://www.asmusa.org/asm.htm, Fax: (202)942-9342:

M. PISTELLO; D. MATTEUCCI; G. CAMMAROTA; P. MAZZETTI; S. GIANNECCHINI; D. DEL MAURO; S MACCHI; L. ZACCARO; AND M. BENDINELLI (1999). Kinetics of replication of a partially attenuated virus and of the challenge virus during a three-year intersubtype feline immunodeficiency virus superinfection experiment in cats.. JOURNAL OF VIROLOGY, vol. 73, pp. 1518-1527, ISSN:0022-538X, American Society for Microbiology / DC:1752 N Street Northwest:Washington, DC 20036:(202)737-3600, EMAIL: jadelman@asmusa.org, INTERNET: http://www.asmusa.org/asm.htm, Fax: (202)942-9342:

D. MATTEUCCI; M. PISTELLO; P. MAZZETTI; S. GIANNECCHINI; P. ISOLA; A. MERICO; L. ZACCARO; A. RIZZUTI AND M. BENDINELLI (1999). AIDS vaccination studies using feline immunodeficiency virus as a model: immunisation with inactivated whole virus suppresses viraemia levels following intravaginal challenge with infected cells but not following intravenous challenge with cell-free virus.. VACCINE, vol. 18, pp. 119-130, ISSN:0264-410X, Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010:

P. MAZZETTI; S. GIANNECCHINI; D. DEL MAURO; D. MATTEUCCI; P. PORTINCASA; A. MERICO; C. GHEZZI; AND M. BENDINELLI (1999). AIDS vaccination studies using an ex vivo feline immunodeficiency virus model: detailed analysis of the humoral immune response to a protective vaccine.. JOURNAL OF VIROLOGY, vol. 73, pp. 1-10, ISSN:0022-538X, American Society for Microbiology / DC:1752 N Street Northwest:Washington, DC 20036:(202)737-3600, EMAIL: jadelman@asmusa.org, INTERNET: http://www.asmusa.org/asm.htm, Fax: (202)942-9342:

D. DEL MAURO; D. MATTEUCCI; S. GIANNECCHINI; F. MAGGI; M. PISTELLO; AND M. BENDINELLI (1998). Autologous and heterologous neutralization analyses of primary feline immunodeficiency virus isolates.. JOURNAL OF VIROLOGY, vol. 72, pp. 2199-2207, ISSN:0022-538X, American Society for Microbiology / DC:1752 N Street Northwest:Washington, DC 20036:(202)737-3600, EMAIL: jadelman@asmusa.org, INTERNET: http://www.asmusa.org/asm.htm, Fax: (202)942-9342:

L. CHIARANTINO; D. MATTEUCCI; M. PISTELLO; U. MANCINI; P. MAZZETTI; C. MASSI; S. GIANNECCHINI; I. LONETTI; M. MAGNANI; AND M. BENDINELLI (1998). AIDS vaccination studies using an ex vivo feline immunodeficiency virus model: homologous erythrocytes as a delivery system for preferential immunization with putative protective antigens.. CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, vol. 5, pp. 235-241, ISSN:1071-412X, American Society for Microbiology:PO Box 11127:Birmingham, AL 35201:(800)633-4931, (205)995-1567, EMAIL: asm.nonmembers.subs@ebsco.com, INTERNET: http://www.asm.org, Fax: (205)995-1588:

S. GIANNECCHINI; D. MATTEUCCI; AND M. BENDINELLI (1998). Effect of enzymatic deglycosylation on feline immunodeficiency virus sensitivity to antibody-mediated neutralization.. AIDS RESEARCH AND HUMAN RETROVIRUSES, vol. 14, pp. 199-204, ISSN:0889-2229, Mary Ann Liebert Incorporated:2 Madison Avenue:Larchmont, NY 10538:(914)834-3100, EMAIL: info@liebertpub.com, swilliams@liebertpub.com, INTERNET: http://www.liebertpub.com, Fax: (914)834-3688:

D. MATTEUCCI; M. PISTELLO; P. MAZZETTI; S. GIANNECCHINI; D. DEL MAURO; I. LONETTI; L. ZACCARO; C. POLLERA; S. SPECTER AND M. BENDINELLI (1997). Sudies on AIDS vaccination using an ex vivo feline immunodeficiency virus model: protection conferred by a fixed-cell vaccine against cell-free and cell-associated challenge differs in duration and is not easily boosted.. JOURNAL OF VIROLOGY, vol. 71, pp. 8368-8376, ISSN:0022-538X, American Society for Microbiology / DC:1752 N Street Northwest:Washington, DC 20036:(202)737-3600, EMAIL: jadelman@asmusa.org, INTERNET: http://www.asmusa.org/asm.htm, Fax: (202)942-9342:

S. GIANNECCHINI; D. MATTEUCCI; P. MAZZETTI; AND M. BENDINELLI (1996). INCUBATION TIME FOR FELINE IMMUNODEFICIENCY VIRUS CULTURES.. JOURNAL OF CLINICAL MICROBIOLOGY, vol. 34, pp. 2036-2038, ISSN:0095-1137, American Society for Microbiology / DC:1752 N Street Northwest:Washington, DC 20036:(202)737-3600, EMAIL: jadelman@asmusa.org, INTERNET: http://www.asmusa.org/asm.htm, Fax: (202)942-9342:

G. CAMMAROTA; D. MATTEUCCI; M. PISTELLO; E. NICOLETTI; S. GIANNECCHINI; AND M. BENDINELLI (1996). Reduced sensitivity to strain-specific neutralization of laboratory-adapted feline immunodeficiency virus after one passage in vivo: association with amino acid substitutions in V4 region of the surface glycoprotein.. AIDS RESEARCH AND HUMAN RETROVIRUSES, vol. 12, pp. 173-175, ISSN:0889-2229, Mary Ann Liebert Incorporated:2 Madison Avenue:Larchmont, NY 10538:(914)834-3100, EMAIL: info@liebertpub.com, swilliams@liebertpub.com, INTERNET: http://www.liebertpub.com, Fax: (914)834-3688:

D. MATTEUCCI; M. PISTELLO; P. MAZZETTI; S. GIANNECCHINI; D. DEL MAURO; L. ZACCARO; P. BANDECCHI; F. TOZZINI; AND M. BENDINELLI (1996). Vaccination protects against in vivo-grown feline immunodeficiency virus even in the absence of detectable neutralizating antibodies.. JOURNAL OF VIROLOGY, vol. 70, pp. 617-622, ISSN:0022-538X, American Society for Microbiology / DC:1752 N Street Northwest:Washington, DC 20036:(202)737-3600, EMAIL: jadelman@asmusa.org, INTERNET: http://www.asmusa.org/asm.htm, Fax: (202)942-9342:

S. GIANNECCHINI; C. AMATO; L. VACCARI; E. BALESTRERI; A. PODEST; AND R. FELICIOLI (1995). The inhibition of a plant proteinase by lysine copolymers is modulated by the hydrophobicity of interposed amino acid side chains.. LETTERS IN PEPTIDE SCIENCE, vol. 2, pp. 333-338, ISSN:0929-5666, Kluwer Academic Publishers:Journals Department, PO Box 322, 3300 AH Dordrecht Netherlands:011 31 78 6576050, EMAIL: frontoffice@wkap.nl, kluweronline@wkap.nl, INTERNET: http://www.kluwerlaw.com, Fax: 011 31 78 6576254:

Simone GIANNECCHINI

Curriculum

First name: SIMONE Last name: GIANNECCHINI (Date of Birth: 1.1.1969 Place of Birth: Viareggio (Lucca) Nationality: Italian citizen) Professional position: Associate Professor of MED/07, University of Florence

Education. Degree in Biological Sciences in 1993, University of Pisa. Professional qualification to Biologist in 1995, University of Pisa. PhD in "Immunobiology of Virus" in 1998, University of Pisa. Master in E-Medicine in 2006, University of Florence. From 2004 to 2006 time-dependent researcher, University of Florence. National scientific qualifications as associate Professor in the sector 05/I1 -Genetics and microbiology National scientific qualifications as associate Professor in the sector 06/A3 -Microbiology and Clinical Microbiology

Scholarships, patents and awards. Two-years post PhD fellowship in 1998, University of Pisa. ANLAIDS Scholarships in 2000 entitled to professor “G.B. Rossi”. Fellowships of the Istituto Superiore di Sanità in 2002. Patent “Oligopeptides and their use in the pharmacological treatment of the FIV in the cat”, HIPPOCAMPE S. A. (MYMETICS SA) deposited in France in 2001. Award scientific entitled to Prof. Giovan Battista Rossi as a "Best Young Italian Researcher for AIDS Studies" in 2002.

Research activities. He has 25-years experience in cellular and molecular biology applied to the study of pathogenesis of viruses infections and their prevention. His main interest is focused on the molecular mechanism of the immunopathogenesis of infection by viruses and on the antiviral development. Main research topics: Polyomaviruses studies: his research involves the study of viral and molecular mechanisms of host cellular factors that may be implicated in the reactivation of human Polyomaviruses (polyomavirus JC (JCPyV), polyomavirus BK (BKPyV)) in patients immunosuppressed (HIV patients and patients with Multiple Sclerosis under treatment of monoclonal Natalizumab drug therapy) and which can determine the beginning of the development of diseases associated with these polyomaviruses (Progressive multifocal leukoencephalopathy, polyomavirus associated nephropathy). In particular, the studies are aimed at identifying the role of viral microRNAs present in exosomes that are found circulating in biological fluids in viral persistence and reactivation and induction of disease in immunocompromised conditions. These studies have provided scientific collaborations with leaders of national / international experience of the University of Kobe, Japan and University of Basel. Influenza viruses studies: genetic study of interspecies transmission of avian influenza virus to identify possible molecular markers involved in the transmission / pathogenicity of avian viruses. In addition, his studies focused on the development of new anti-influenza virus nucleic acid based drugs designed on the packaging of viral genomic sequences for the construction of innovative therapies. These studies have provided scientific collaborations with leaders of national / international experience of the University of Padua, Zooprophylactic delle Venezie Institute, National Institute of Health. In the context of emerging viruses: study as responsible for operating units in projects involving the development of new drugs to treat universal Arbovirus. Lentiviruses studies: study of the neutralization mechanisms and pathogenesis of lentivirus using the model of feline immunodeficiency virus (FIV). Development of new antivirals based on the fusion protein sequences for the development of inhibitors of the viral fusion as a model to develop therapies for HIV. These studies have provided collaborations with international experts in research of animal models for AIDS.

Activity of Virological surveillance activities of flu pandemic and the epidemic period. From 2004 to 2015 he participated as a collaborator. He has recently become responsible. Isolation on MDCK and molecular typing of influenza virus clinical specimens collected by sentinel physicians are part of the Tuscan circuit for monitoring of influenza viruses and sent to the regional reference center (Department of Experimental and Clinical Medicine, lab. Virology). Next send the results of the same samples at the Higher Institute of Health National Reference Center, Rome.

Collaborator on University Clinical activity at diagnostic unit of Microbiology and Virology of the Ospedaliera-Universitaria Careggi. molecular diagnosis of influenza virus infection monitoring Polyomavirus JC and monitoring of Arbovirus infection (Zika and West Nile virus). Implementation and development of molecular diagnostic methods support.

Partecipant: Italian Society of Microbiology (SIM); Italian Society of Virology (SIV-ISV); European Society of Virology (ESV). Editor of the World Journal of Virology, peer-reviewed online open-access journal of virology (2011-2018).