Personale

Recapiti

Orario di ricevimento

Italiano

Biografia

Curriculum

Interessi

Note

Pubblicazioni

Insegnamenti

English

Biography

Curriculum

Interest

Note

Chiara DONATI

Ruolo attuale:: Professore Ordinario
SSD:: BIOS-10/A - Biologia cellulare e applicata
Afferenza organizzativa:: Dipartimento di Scienze Biomediche, Sperimentali e Cliniche 'Mario Serio'

Recapiti

	0552751204
	chiara.donati(AT)unifi.it

Ulteriori Recapiti

https://www.sbsc.unifi.it/vp-482-gruppo-donati.html

Chiara DONATI

Orario di ricevimento (aggiornato al 03/03/2025)

Giovedi 13-15 su appuntamento, fissato via e-mail all'indirizzo chiara.donati@unifi.it

Chiara DONATI

Biografia

1992 Maturità Classica

1998 Laurea in Scienze Biologiche

2002 Diploma di Specializzazione in Biochimica e Chimica Clinica

2006 Diploma di Dottorato di Ricerca in Biochimica e Biologia Applicata

2004 Ricercatore settore disciplinare BIO/13.

2015 Professore associato settore disciplinare BIO/13

2024 Professore ordinario settore disciplinare BIOS10/A (ex BIO/13)

Chiara DONATI

Curriculum

STUDI COMPIUTI

1992 Maturità Classica

1998 Laurea in Scienze Biologiche conseguita presso l'Università degli Studi di Firenze con votazione di 110/110 e lode. 2002 Diploma di Specializzazione in Biochimica e Chimica Clinica conseguito presso la Scuola di Specializzazione in Biochimica e Chimica Clinica, Facoltà di Medicina e Chirurgia, Università degli Studi di Firenze con votazione 70/70 e lode. 2006 Diploma di Dottorato di Ricerca in Biochimica e Biologia Applicata (XVIII ciclo), conseguito presso il Dipartimento di Scienze Biochimiche, Università di Firenze.

Società scientifiche

Socio, Società Italiana di Biochimica e Biologia Molecolare, SIB (dal 2004)

Socio, Istituto Interuniversitario di Miologia (dal 2004)

Socio, Società Italiana di Biologia e Genetica, AIBG (dal 2005)

Socio, Associazione di Biologia Cellulare e del Differenziamento, ABCD (dal 2011)

ESPERIENZE PROFESSIONALI

2000-2002 Visiting fellow presso i National Institutes of Health, Bethesda Maryland, USA.

2004-2015 Ricercatore confermato settore disciplinare BIO/13.

2015 Professore associato settore disciplinare BIO/13.

2024 Professore ordinario settore disciplinare BIOS10/A.

Chiara DONATI

Interessi

- Caratterizzazione del ruolo dei metaboliti bioattivi del catabolismo della sfingomielina, in particolare sfingosina 1-fosfato, nella rigenerazione del muscolo scheletrico ed identificazione dei meccanismi fisiologici del suo controllo.

- Caratterizzazione del ruolo dei metaboliti bioattivi del catabolismo della sfingomielina, in particolare sfingosina 1-fosfato, nella regolazione di processi biologici fondamentali quali proliferazione, differenziamento, sopravvivenza, migrazione di cellule staminali mesenchimali quali mesoangioblasti, cellule mesenchimali staminali derivanti da tessuto adiposo e progenitori della vescicola otica.

- Caratterizzazione del ruolo fisiologico e dei meccanismi molecolari alla base del cross-talk funzionale esistente tra il signalling di sfingolipidi e quello di citochine (TNFa, TGFb) e fattori di crescita (IGF-1, Insulina, PDGF) nella biologia di cellule staminali residenti nel muscolo scheletrico e di progenitori staminali mesenchimali.

- Caratterizzazione del ruolo di sfingosina 1-fosfato, del suo metabolismo e dei suoi recettori nell'interazione funzionale cellule gliali/neuroni in seguito a trattamento con oligomeri del peptide beta amiloide e alfa-sinucleina.

- Caratterizzazione del ruolo di sfingosina 1-fosfato , del suo metabolismo e della sua segnalazione nei disordini uterini benigni quali endometriosi, adenomiosi e fibromi uterini.

-Caratterizzazione del ruolo di sfingosina 1-fosfato, del suo metabolismo e della sua segnalazione nella comunicazione mediata da esosomi nella infertilità maschile associata all'obesità.

Chiara DONATI

Note

E' stata Consigliere del Consiglio Universitario Nazionale (CUN) in rappresentanza della II fascia, area 05 Scienze Biologiche, da maggio 2019 a aprile 2023.

Membro del Presidio Qualità di Ateneo (PQA), Università degli Studi di Firenze, dal 31 luglio 2023.

E’ stata membro della Commissione di Indirizzo e Autovalutazione (CIA) del Dipartimento di Scienze Biomediche Sperimentali e Cliniche “Mario Serio”, Università di degli Studi di Firenze dal 2021 al 2023.

E’ stata membro della Giunta dell’Associazione Italiana di Biologia e Genetica generale e molecolare (AIBG) dal 2019 al 2021.

E’ attualmente segretario/tesoriere dell’Associazione Italiana di Biologia e Genetica generale e molecolare (AIBG) da gennaio 2023.

Dal 2017 ad oggi è membro del Collegio dei Docenti del Dottorato di ricerca in Biochemistry and Molecular Biology- BIBIM2.0, Università degli Studi di Siena.

Chiara DONATI

Pubblicazioni

Legenda

Contributo su rivista |

Articolo su libro |

Libro |

Contributo in atti di convegno (proceeding) |

Brevetto |

Curatela | Altro

Altro |

Tesi di Dottorato

Rossi, Margherita; Seidita, Isabelle; Prisinzano, Matteo; Raeispour, Maryam; Romeo, Lucia; Sorbi, Flavia; Fambrini, Massimiliano; Ciarmela, Pasquapina; Petraglia, Felice; Bernacchioni, Caterina; Donati, Chiara (In corso di stampa). Sphingosine 1-phosphate acts as proliferative and fibrotic cue in leiomyoma cells. F&S SCIENCE, pp. 0-0, ISSN:2666-335X DOI

Vannuccini, Silvia; Gabbrielli, Silvia; Castiglione, Francesca; Nardi, Eleonora; Rossi, Margherita; Orlandi, Gretha; Wu, Elisa; Bertoli, Francesca; Miele, Vittorio; Donati, Chiara; Petraglia, Felice (2024). Imaging and molecular features of adenomyosis after menopause. MATURITAS, vol. 185, pp. 0-0, ISSN:0378-5122 DOI

Giacomazzo, Gina Elena; Conti, Luca; Paderni, Daniele; Sfragano, Patrick Severin; Quadrini, Lorenzo; Macedi, Eleonora; Andreini, Camilla; Donati, Chiara; Bernacchioni, Caterina; Mulas, Gloria; Valtancoli, Barbara; Palchetti, Ilaria; Giorgi, Luca; Fusi, Vieri; Cencetti, Francesca; Giorgi, Claudia (2024). Ruthenium(II) Polypyridyl Complexes with Benzoxazole Derivatives and Non‐Innocent Ligands as Effective Antioxidants in Human Neuroblasts. CHEMISTRY-A EUROPEAN JOURNAL, pp. 1-14, ISSN:0947-6539 DOI Accesso ONLINE all'editore

Prisinzano M.; Bernacchioni C.; Seidita I.; Rossi M.; Raeispour M.; Cencetti F.; Vannuccini S.; Fambrini M.; Petraglia F.; Bruni P.; Donati C. (2024). Sphingosine 1-phosphate signaling axis mediates neuropeptide S-induced invasive phenotype of endometriotic cells. THE FEBS JOURNAL, vol. 291, pp. 1744-1758, ISSN:1742-464X DOI

Bernacchioni, Caterina; Rossi, Margherita; Vannuzzi, Valentina; Prisinzano, Matteo; Seidita, Isabelle; Raeispour, Maryam; Muccilli, Angela; Castiglione, Francesca; Bruni, Paola; Petraglia, Felice; Donati, Chiara (2024). Sphingosine-1-phosphate receptor 3 is a non-hormonal target to counteract endometriosis-associated fibrosis. FERTILITY AND STERILITY, vol. 121, pp. 631-641, ISSN:0015-0282 DOI

Polvani, S.; Mello, T.; Ceni, E.; Guida, A.; Picariello, L.; Grappone, C.; Dragoni, G.; Lynch, E.N.; Innocenti, T.; Tarocchi, M.; Donati, C.; Bruni, P.; Milani, S.; Galli, A. (2023). T.03.4 SPHINGOSINES, COUP-TFII AND PANCREATIC CANCER. DIGESTIVE AND LIVER DISEASE, vol. 55, pp. S142-S146, ISSN:1590-8658 DOI

Garella Rachele, Bernacchioni Caterina, Chellini Flaminia, Tani Alessia, Palmieri Francesco, Parigi Martina, Guasti Daniele, Cassioli Emanuele, Castellini Giovanni, Ricca Valdo, Bani Daniele, Sassoli Chiara, Donati Chiara, Squecco Roberta (2023). Adiponectin modulates smooth muscle cell morpho-functional properties in murine gastric fundus via sphingosine kinase 2 activation. LIFE, vol. 13, pp. 0-0, ISSN:2075-1729 DOI Accesso ONLINE all'editore

Rossi, Margherita; Seidita, Isabelle; Vannuccini, Silvia; Prisinzano, Matteo; Donati, Chiara; Petraglia, Felice (2023). Epigenetics, endometriosis and sex steroid receptors: An update on the epigenetic regulatory mechanisms of estrogen and progesterone receptors in patients with endometriosis. VITAMINS AND HORMONES, vol. 122, pp. 171-191, ISSN:0083-6729 DOI

Bigi A, Cascella R, Fani G, Bernacchioni C, Cencetti F, Bruni P, Chiti F, Donati C, Cecchi C. (2023). Sphingosine 1-phosphate attenuates neuronal dysfunction induced by amyloid-β oligomers through endocytic internalization of NMDA receptors. THE FEBS JOURNAL, vol. 290, pp. 112-133, ISSN:1742-4658 DOI

Mazzoli A.; Porzio A.D.; Gatto C.; Crescenzo R.; Nazzaro M.; Spagnuolo M.S.; Baccigalupi L.; Ricca E.; Amoresano A.; Fontanarosa C.; Bernacchioni C.; Donati C.; Iossa S.; Cigliano L. (2023). Skeletal muscle insulin resistance and adipose tissue hypertrophy persist beyond the reshaping of gut microbiota in young rats fed a fructose-rich diet. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, vol. 113, pp. 109247-109262, ISSN:0955-2863 DOI

Garcia Garcia, Jose Manuel; Vannuzzi, Valentina; Donati, Chiara; Bernacchioni, Caterina; Bruni, Paola; Petraglia, Felice (2023). Endometriosis: Cellular and Molecular Mechanisms Leading to Fibrosis. REPRODUCTIVE SCIENCES, pp. 1453-1461, ISSN:1933-7205 DOI

Seidita, Isabelle; Tusa, Ignazia; Prisinzano, Matteo; Menconi, Alessio; Cencetti, Francesca; Vannuccini, Silvia; Castiglione, Francesca; Bruni, Paola; Petraglia, Felice; Bernacchioni, Caterina; Rovida, Elisabetta; Donati, Chiara (2023). Sphingosine 1-phosphate elicits a ROS-mediated proinflammatory response in human endometrial stromal cells via ERK5 activation. THE FASEB JOURNAL, vol. 37, pp. 0-0, ISSN:0892-6638 DOI Accesso ONLINE all'editore

Margherita Rossi; Silvia Vannuccini; Tommaso Capezzuoli; Massimiliano Fambrini; Valentina Vannuzzi; Chiara Donati; Felice Petraglia (2022). Mechanisms and Pathogenesis of Adenomyosis. CURRENT OBSTETRICS AND GYNECOLOGY REPORTS, vol. 11, pp. 95-102, ISSN:2161-3303 DOI

Vannuzzi, Valentina; Bernacchioni, Caterina; Muccilli, Angela; Castiglione, Francesca; Nozzoli, Filippo; Vannuccini, Silvia; Capezzuoli, Tommaso; Ceccaroni, Marcello; Bruni, Paola; Donati, Chiara; Petraglia, Felice (2022). Sphingosine 1-phosphate pathway is dysregulated in adenomyosis. REPRODUCTIVE BIOMEDICINE ONLINE, vol. 45, pp. 15-18, ISSN:1472-6491 DOI

Standoli, S; Pecchioli, S; Tortolani, D; Di Meo, C; Fanti, F; Sergi, M; Bacci, M; Seidita, I; Bernacchioni, C; Donati, C; Bruni, P; Maccarrone, M; Rapino, C; Cencetti, F (2022). The TRPV1 Receptor Is Up-Regulated by Sphingosine 1-Phosphate and Is Implicated in the Anandamide-Dependent Regulation of Mitochondrial Activity in C2C12 Myoblasts. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, pp. 1-20, ISSN:1661-6596 DOI Accesso ONLINE all'editore

Caterina Bernacchioni, Tommaso Capezzuoli, Valentina Vannuzzi, Francesca Malentacchi, Francesca Castiglione, Francesca Cencetti, Marcello Ceccaroni , Chiara Donati, Paola Bruni, Felice Petraglia (2021). Sphingosine 1-phosphate receptors are dysregulated in endometriosis: possible implication in transforming growth factor β-induced fibrosis. FERTILITY AND STERILITY, vol. 115, pp. 501-511, ISSN:0015-0282 DOI

Corvino, Angela; Cerqua, Ida; Lo Bianco, Alessandra; Caliendo, Giuseppe; Fiorino, Ferdinando; Frecentese, Francesco; Magli, Elisa; Morelli, Elena; Perissutti, Elisa; Santagada, Vincenzo; Cirino, Giuseppe; Granato, Elisabetta; Roviezzo, Fiorentina; Puliti, Elisa; Bernacchioni, Caterina; Lavecchia, Antonio; Donati, Chiara; Severino, Beatrice (2021). Antagonizing S1P3 Receptor with Cell-Penetrating Pepducins in Skeletal Muscle Fibrosis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, pp. 8861-8875, ISSN:1422-0067 DOI

Coppi E.; Cencetti F.; Cherchi F.; Venturini M.; Donati C.; Bruni P.; Pedata F.; Pugliese A.M. (2021). A2B Adenosine Receptors and Sphingosine 1-Phosphate Signaling Cross-Talk in Oligodendrogliogenesis. FRONTIERS IN NEUROSCIENCE, vol. 15, pp. 677988-678007, ISSN:1662-4548 DOI

Ana Gomez-Larrauri , Patricia Gangoiti , Natalia Presa , Asier Dominguez-Herrera , Chiara Donati , Paola Bruni , Miguel Trueba , Antonio Gomez-Muñoz , Alberto Ouro (2021). Phosphatidic Acid Stimulates Myoblast Proliferation through Interaction with LPA1 and LPA2 Receptors. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, pp. 0-0, ISSN:1661-6596 DOI

Chiara Donati , Francesca Cencetti, Caterina Bernacchioni, Valentina Vannuzzi, Paola Bruni (2021). Role of sphingosine 1-phosphate signalling in tissue fibrosis. CELLULAR SIGNALLING, vol. 78, pp. 0-0, ISSN:0898-6568 DOI

Bernacchioni C.; Ciarmela P.; Vannuzzi V.; Greco S.; Vannuccini S.; Malentacchi F.; Pellegrino P.; Capezzuoli T.; Sorbi F.; Cencetti F.; Bruni P.; Donati C.; Petraglia F. (2021). Sphingosine 1-phosphate signaling in uterine fibroids: implication in activin A pro-fibrotic effect. FERTILITY AND STERILITY, vol. 115, pp. 1576-1585, ISSN:0015-0282 DOI

Bernacchioni C.; Ghini V.; Squecco R.; Idrizaj E.; Garella R.; Puliti E.; Cencetti F.; Bruni P.; Donati C. (2021). Role of sphingosine 1-phosphate signalling axis in muscle atrophy induced by tnfα in c2c12 myotubes. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, pp. 1-19, ISSN:1661-6596 DOI

Coppi E.; Cherchi F.; Fusco I.; Dettori I.; Gaviano L.; Magni G.; Catarzi D.; Colotta V.; Varano F.; Rossi F.; Bernacchioni C.; Donati C.; Bruni P.; Pedata F.; Cencetti F.; Pugliese A.M. (2020). Adenosine A2B receptors inhibit K+ currents and cell differentiation in cultured oligodendrocyte precursor cells and modulate sphingosine-1-phosphate signaling pathway. BIOCHEMICAL PHARMACOLOGY, vol. 177, pp. 1-7, ISSN:0006-2952 DOI

Bruno G, Cencetti F, Pini A, Tondo A, Cuzzubbo D, Fontani F, Strinna V, Buccoliero AM, Casazza G, Donati C, Filippi L, Bruni P, Favre C, Calvani M (2020). β3-adrenoreceptor blockade reduces tumor growth and increases neuronal differentiation in neuroblastoma via SK2/S1P2 modulation. ONCOGENE, vol. 39, pp. 368-384, ISSN:1476-5594 DOI Accesso ONLINE all'editore

Cencetti F.; Bruno G.; Bernacchioni C.; Japtok L.; Puliti E.; Donati C.; Bruni P. (2020). Sphingosine 1-phosphate lyase blockade elicits myogenic differentiation of murine myoblasts acting via Spns2/S1P2 receptor axis. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, vol. 1865, pp. 0-0, ISSN:1388-1981 DOI

Polykretis, P.; Cencetti, F.; Donati, C.; Luchinat, E.; Banci, L. (2019). Cadmium effects on superoxide dismutase 1 in human cells revealed by NMR. REDOX BIOLOGY, vol. 21, pp. 1-7, ISSN:2213-2317 DOI Accesso ONLINE all'editore

BERNACCHIONI CATERINA, CENCETTI FRANCESCA, DONATI CHIARA, BRUNI PAOLA (2019). Sphingosine 1‐Phosphate Signalling. In: Caterina Bernacchioni, Francesca Cencetti, Chiara Donati, Paola Bruni. eLS, pp. 0-0 Wiley Online Library https://onlinelibrary.wiley.com/, ISBN:9780470015902. DOI Accesso ONLINE all'editore

Cencetti F, Bernacchioni C, Bruno M, Squecco R, Idrizaj E, Berbeglia M, Bruni P, Donati C (2019). Sphingosine 1-phosphate-mediated activation of ezrin-radixin-moesin proteins contributes to cytoskeletal remodeling and changes of membrane properties in epithelial otic vesicle progenitors.. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, vol. 1866, pp. 554-565, ISSN:0167-4889 DOI

Rita Romani , Giorgia Manni , Chiara Donati , Irene Pirisinu , Caterina Bernacchioni , Marco Gargaro , Matteo Pirro , Mario Calvitti , Francesco Bagaglia , Amirhossein Sahebkar , Graziano Clerici , Davide Matino , Giovanni Pomili , Gian Carlo Di Renzo , Vincenzo Nicola Talesa , Paolo Puccetti, Francesca Fallarino (2018). S1P promotes migration, differentiation and immune regulatory activity in amniotic-fluid– derived stem cells. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 833, pp. 173-182, ISSN:0014-2999 DOI

Caterina Bernacchioni, Francesca Cencetti,Alberto Ouro, Marina Bruno,Antonio Gomez-Muñoz, Chiara Donati, Paola Bruni (2018). Lysophosphatidic Acid Signaling Axis Mediates Ceramide 1-Phosphate-Induced Proliferation of C2C12 Myoblasts.. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 19, pp. 139-157, ISSN:1422-0067

Chiara Donati, Elena Battaglioli, Tania Gamberi, Francesca Magherini, Massimo Pasqualetti, Barbara Pelosi (2018). Il mondo della cellula. Ediz. mylab. di Jeff Hardin, Gregory Paul Bertoni, Torino: Pearson Italia spa, 9788891904492.

Gennaro Bruno, Francesca Cencetti, Caterina Bernacchioni, Chiara Donati, Kira Vanessa Blankenbach, Dominique Thomas, Dagmar Meyer zu Heringdorf, Paola Bruni (2018). Bradykinin mediates myogenic differentiation in murine myoblasts through the involvement of SK1/Spns2/S1P2 axis. CELLULAR SIGNALLING, vol. 45, pp. 110-121, ISSN:0898-6568 DOI Accesso ONLINE all'editore

Bernacchioni, Caterina; Turano, Paola; Donati, Chiara (2017). Targeting sphingosine kinase 1 localization as novel target for ovarian cancer therapy. TRANSLATIONAL CANCER RESEARCH, vol. 6, pp. S1277-S1280, ISSN:2218-676X DOI Accesso ONLINE all'editore

Bruno, M; Rizzo, Im; Romero-Guevara, R; Bernacchioni, C; Cencetti, F; Donati, C; Bruni, P. (2017). Sphingosine 1-phosphate signaling axis mediates fibroblast growth factor 2-induced proliferation and survival of murine auditory neuroblasts. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, vol. 1864(5), pp. 814-824, ISSN:0167-4889 DOI

Anna Maria Pugliese, ; Irene, Fusco; Francesca, Cencetti; Ilaria, Dettori; Lisa, Gaviano; Chiara, Donati; Paola, Bruni; Daniela, Catarzi; Elisabetta, Coppi; Felicita, Pedata (2017). Activation of adenosine A 2B receptors and sphingosine kinase/sphingosine 1-phosphate signaling axis modulates the amplitude of outward K + currents and maturation of oligodendrocyte precursor cells. PURINERGIC SIGNALLING, pp. 631-632, ISSN:1573-9538 DOI

Bernacchioni, Caterina; Ghini, Veronica; Cencetti, Francesca; Japtok, Lukasz; Donati, Chiara; Bruni, Paola; Turano, Paola (2017). NMR metabolomics highlights sphingosine kinase-1 as a new molecular switch in the orchestration of aberrant metabolic phenotype in cancer cells. MOLECULAR ONCOLOGY, vol. 11, pp. 517-533-533, ISSN:1574-7891 DOI

Bondi, M; Germinario, E; Pirazzini, M; Zanetti, G; Cencetti, F; Donati, C; Gorza, L; Betto, R; Bruni, P; Danieli-Betto. (2017). The ablation of S1P3 receptor protects mouse soleus from age-related drop of muscle mass, force and regenerative capacity.. AMERICAN JOURNAL OF PHYSIOLOGY. CELL PHYSIOLOGY, pp. 0-0, ISSN:1522-1563 DOI

Germinario, Elena; Bondì, Michela; Cencetti, Francesca; Donati, Chiara; Nocella, Marta; Colombini, Barbara; Betto, Romeo; Bruni, Paola; Bagni, Maria Angela; Danieli-Betto, Daniela (2016). S1P3 receptor influences key physiological properties of fast-twitch extensor digitorum longus muscle.. JOURNAL OF APPLIED PHYSIOLOGY, vol. 120, pp. 1288-1300, ISSN:8750-7587 DOI

Romero-Guevara, Ricardo; Cencetti, Francesca; Donati, Chiara; Bruni, Paola (2015). Sphingosine 1-phosphate signaling pathway in inner ear biology. New therapeutic strategies for hearing loss?. FRONTIERS IN AGING NEUROSCIENCE, vol. 7, pp. 0-0, ISSN:1663-4365 DOI Accesso ONLINE all'editore

Laurenzana, Anna; Cencetti, Francesca; Serratì, Simona; Bruno, Gennaro; Japtok, Lukasz; Bianchini, Francesca; Torre, Eugenio; Fibbi, Gabriella; Del Rosso, Mario; Bruni, Paola; Donati, Chiara . (2015). Endothelial sphingosine kinase/SPNS2 axis has a critical role in migration and vessel-like formation of human mesoangioblasts. JOURNAL OF MOLECULAR MEDICINE, vol. 93, pp. 1145-1157, ISSN:0946-2716 DOI

Gennaro Bruno; Francesca Cencetti; Irene Pertici; Lukasz Japtok; Caterina Bernacchioni; Chiara Donati; Paola Bruni (2015). CTGF/CCN2 exerts profibrotic action in myoblasts via up-regulation of sphingosine kinase-1/S1P3 signaling axis: implications in the action mechanism of TGFβ. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, vol. 1851(2), pp. 194-202, ISSN:1388-1981 DOI

Cencetti F; Bruno G; Blescia S; Bernacchioni C; Bruni P; Donati C. (2014). Lysophosphatidic acid stimulates cell migration of satellite cells. A role for the sphingosine kinase/sphingosine 1-phosphate axis.. THE FEBS JOURNAL, vol. 281(19), pp. 4467-4478, ISSN:1742-4658 DOI

Cencetti F; Bernacchioni C; Tonelli F; Roberts E; Donati C; Bruni P. (2013). TGFβ1 evokes myoblast apoptotic response via a novel signaling pathway involving S1P4 transactivation upstream of Rho-kinase-2 activation.. THE FASEB JOURNAL, vol. 27, pp. 4532-4546, ISSN:0892-6638 DOI

Donati C; Cencetti F; Bruni P. (2013). Sphingosine 1-phosphate axis: a new leader actor in skeletal muscle biology.. FRONTIERS IN PHYSIOLOGY, vol. 4, 338, pp. 1-10, ISSN:1664-042X DOI

Donati C; Cencetti F; Bruni P (2013). New insights into the role of sphingosine 1-phosphate and lysophosphatidic acid in the regulation of skeletal muscle cell biology. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, vol. 1831, pp. 176-184, ISSN:1388-1981 Accesso ONLINE all'editore

Corti, Francesca; Cellai, Lucrezia; Melani, Alessia; Donati, Chiara; Bruni, Paola; Pedata, Felicita (2013). Adenosine is present in rat brain synaptic vesicles.. NEUROREPORT, vol. 24, pp. 982-987, ISSN:0959-4965 DOI

Bruni P; Donati C. (2013). Role of sphingosine 1-phosphate in skeletal muscle cell biology.. In: Gulbins, Erich; Petrache, Irina. Sphingolipids in Disease, pp. 457-467 -Springer Verlag Germany:Tiergartenstrasse 17, D 69121 Heidelberg Germany:011 49 6221 3450, EMAIL: g.braun@springer.de, INTERNET: http://www.springer.de, Fax: 011 49 6221 345229 -SPRINGER, 233 SPRING STREET, NEW YORK, USA, NY, 10013. DOI

Germinario E; Peron S; Toniolo L; Betto R; Cencetti F; Donati C; Bruni P; Danieli-Betto D. (2012). S1P2 receptor promotes mouse skeletal muscle regeneration.. JOURNAL OF APPLIED PHYSIOLOGY, vol. 113, pp. 707-713, ISSN:8750-7587 Accesso ONLINE all'editore

Melani A; Corti F; Stephan H; Müller CE; Donati C; Bruni P; Vannucchi MG; Pedata F (2012). Ecto-ATPase inhibition: ATP and adenosine release under physiological and ischemic in vivo conditions in the rat striatum.. EXPERIMENTAL NEUROLOGY, vol. 233, pp. 193-204, ISSN:0014-4886 DOI

C. Bernacchioni; F. Cencetti; S.Blescia; C. Donati; P. Bruni (2012). Sphingosine kinase/sphingosine 1-phosphate axis: a new player for insulin like growth factor-1-induced myoblast differentiation. SKELETAL MUSCLE, vol. 2, pp. 0-0, ISSN:2044-5040 DOI Accesso ONLINE all'editore

S.Calise;S.Blescia;F.Cencetti;C.Bernacchioni;C.Donati*;P.Bruni* (2012). Sphingosine 1-phosphate stimulates proliferation and migration of satellite cells Role of S1P receptors.. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, vol. 1823, pp. 439-450, ISSN:0167-4889 Accesso ONLINE all'editore

P.Gangoiti*;C.Bernacchioni*; C.Donati;F.Cencetti;A.Ouro;A. Gómez-Muñoz;P.Bruni (2012). Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts.. BIOCHIMIE, vol. 94, pp. 597-607, ISSN:0300-9084 DOI

C. Bernacchioni; F. Cencetti; M. J. Kwon; H.S. Gwak; S.K. Jeong; P. Bruni; C. Donati (2011). The sphingosine kinase activator K6PC-5 stimulates C2C12 myoblast differentiation. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, vol. 24 (1), pp. 55-62, ISSN:0394-6320

V. Meza-Carmen; G.Pacheco-Rodriguez ; G.S. Kang; J. Kato; C. Donati; C.Y. Zhang; A. Vichi; D.M. Payne; S. El-Chemaly; M. Stylianou; J. Moss; M.Vaughan (2011). Regulation of growth factor receptor degradation by ADP-ribosylation factor domain protein (ARD) 1.. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 108(26), pp. 10454-10459, ISSN:0027-8424

C. Donati; G. Marseglia; A. Magi; S. Serratì; F. Cencetti; C. Bernacchioni; G. Nannetti; M. Benelli; S. Brunelli; F. Torricelli; G. Cossu; P. Bruni (2011). Sphingosine 1-phosphate induces differentiation of mesoangioblasts towards smooth muscle. A role for GATA6.. PLOS ONE, vol. ..., pp. 0-0, ISSN:1932-6203

G.Illuzzi;C.Bernacchioni;M.Aureli;S.Prioni;G.Frera;C.Donati;M. Valsecchi;V.Chigorno;P.Bruni;S.Sonnino;A.Prinetti (2010). Sphingosine kinase mediates resistance to the synthetic retinoid N-(4-hydroxyphenyl)retinamide in human ovarian cancer cells.. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, pp. 18594-18602, ISSN:0021-9258 Accesso ONLINE all'editore

F. Cencetti; C. Bernacchioni; P. Nincheri; C. Donati*; P. Bruni* (2010). Transforming Growth Factor-{beta}1 Induces Transdifferentiation of Myoblasts into Myofibroblasts via Up-Regulation of Sphingosine Kinase-1/S1P3 Axis.. MOLECULAR BIOLOGY OF THE CELL, vol. 21, pp. 1111-1124, ISSN:1059-1524

P.Nincheri;C.Bernacchioni;F.Cencetti;C.Donati*;P.Bruni* (2010). Sphingosine kinase-1/S1P1 signalling axis negatively regulates mitogenic response elicited by PDGF in mouse myoblasts. CELLULAR SIGNALLING, vol. 22, pp. 1688-1699, ISSN:0898-6568 Accesso ONLINE all'editore

S.Rigogliuso; C.Donati; D.Cassarà; S.Taverna; M.Salamone; P.Bruni; M.L.Vittorelli (2010). An active form of sphingosine kinase-1 is released in the extracellular medium as component of membrane vesicles shed by two human tumor cell lines.. JOURNAL OF ONCOLOGY, vol. 2010, pp. 1-10, ISSN:1687-8469

Melani A; Cipriani S; Vannucchi MG; Nosi D; Donati C; Bruni P; Giovannini MG; Pedata F (2010). Selective adenosine A(2A) receptor antagonism reduces JNK MAPK activation in oligodendrocytes after cerebral ischaemia. PURINERGIC SIGNALLING, vol. 6, pp. 97-97, ISSN:1573-9538

C.Donati; F.Cencetti; C.De Palma; E.Rapizzi; S.Brunelli; G.Cossu; E.Clementi; P.Bruni (2009). TGFbeta protects mesoangioblasts from apoptosis via sphingosine kinase-1 regulation.. CELLULAR SIGNALLING, vol. 21, pp. 228-236, ISSN:0898-6568

A.Melani; S.Cipriani; MG Vannucchi; D Nosi; C Donati; P Bruni; MG Giovannini; F Pedata (2009). Selective adenosine A2A receptor antagonism reduces JNK activation in oligodendrocytes after cerebral ischemia. BRAIN, vol. 132, pp. 1480-1495, ISSN:0006-8950 DOI Accesso ONLINE all'editore

P.Nincheri; P.Luciani; R.Squecco; C.Donati; C.Bernacchioni; L.Borgognoni; G.Luciani; S.Benvenuti; F.Francini; P. Bruni (2009). Sphingosine 1-phosphate induces differentiation of adipose tissue-derived mesenchymal stem cells towards smooth muscle cells.. CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 66, pp. 1741-1754, ISSN:1420-682X Accesso ONLINE all'editore

E.Rapizzi; M.L.Taddei; T.Fiaschi; C.Donati; P. Bruni; P. Chiarugi (2009). Sphingosine 1-phosphate increases glucose uptake through trans-activation of insulin receptor.. CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 66, pp. 3207-3218, ISSN:1420-682X Accesso ONLINE all'editore

E.MEACCI; C.DONATI; F.NUTI; F.CENCETTI; M.FARNARARO; P.BRUNI (2008). Sphingosine kinase activity is essential for myogenic differentiation of C2C12 myoblasts. JOURNAL OF CELLULAR PHYSIOLOGY, vol. 214, pp. 210-220, ISSN:0021-9541, John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551:

E.Rapizzi; C. Donati; F.Cencetti; P.Nincheri; P. Bruni (2008). Sphingosine 1-phosphate differentially regulates proliferation of C2C12 reserve cells and myoblasts. MOLECULAR AND CELLULAR BIOCHEMISTRY, vol. 314, pp. 193-199, ISSN:0300-8177

P.Bruni; C. Donati (2008). Pleiotropic effects of sphingolipids in skeletal muscle. CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 65, pp. 3725-3736, ISSN:1420-9071

C. DONATI ; P. NINCHERI ; F. CENCETTI ; E. RAPIZZI ; M. FARNARARO ; P. BRUNI (2007). Tumor necrosis factor-α exerts promyogenic action in C2C12 myoblasts via sphingosine kinase/S1P2 signaling.. FEBS LETTERS, vol. 581, pp. 4384-4388, ISSN:0014-5793

RAPIZZI E; DONATI C; CENCETTI F; PINTON P; RIZZUTO R; P. BRUNI (2007). Sphingosine 1-phosphate receptors modulate intracellular Ca2+ homeostasis. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 353, pp. 268-274, ISSN:0006-291X

C. DONATI; F. CENCETTI; P. NINCHERI; C. BERNACCHIONI; S. BRUNELLI; E. CLEMENTI; G. COSSU; P. BRUNI (2007). Sphingosine 1-phosphate mediates proliferation and survival of mesoangioblasts. STEM CELLS, vol. 25(7), pp. 1713-1719, ISSN:1066-5099

C. DONATI; P. BRUNI (2006). SPHINGOSINE 1-PHOSPHATE REGULATES CYTOSKELETON DYNAMICS: IMPLICATIONS IN ITS BIOLOGICAL RESPONSE.. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, vol. 1758, pp. 2037-2048, ISSN:0005-2736

L.Becciolini; E.Meacci;C. Donati; F.Cencetti;E. Rapizzi; P.Bruni (2006). Sphingosine 1-phosphate inhibits cell migration in C2C12 myoblasts. BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1761, pp. 43-51, ISSN:0006-3002

E. Sarchielli; C. Sassoli; L. Becciolini; L. Formigli; C. Donati; G. Nemoz; P. Bruni; E. Meacci. (2006). Localization of sphingosine kinase-1 in detergent resistant membranes of C2C12 myoblasts.. In: 5° International Sphingolipid Meeting, Calella (Spain), November 2-4, 2006, Ghidoni Riccardo, vol. N-S Archives of Parmacology -374-, pp. 4-P25-4-P25.

C. DONATI; E. MEACCI; F. NUTI; L. BECCIOLINI; M. FARNARARO; P. BRUNI (2005). SPHINGOSINE 1-PHOSPHATE REGULATES MYOGENIC DIFFERENTIATION. A MAJOR ROLE FOR S1P2 RECEPTOR. THE FASEB JOURNAL, vol. 19, pp. 449-451, ISSN:0892-6638

E. MEACCI; F. CENCETTI; C. DONATI; F. NUTI; L. BECCIOLINI; P.BRUNI (2004). Sphingosine kinase activity is required for sphingosine-mediated phospholipase D activation in C2C12 myoblasts.. BIOCHEMICAL JOURNAL, vol. 381, pp. 655-663, ISSN:0264-6021

Romiti, E; Meacci, E; Donati, C; Formigli, L; Zecchi-orlandini, S; Farnararo, M; Ito, M; Bruni, P. (2003). Neutral ceramidase secreted by endothelial cells is released in part associated with caveolin-1. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 417, pp. 27-33, ISSN:0003-9861 DOI

E.Meacci; F. Cencetti; C. Donati; F. Nuti; M. Farnararo; T. Kohno; Y. Igarashi; P.Bruni (2003). Down-regulation of EDG5/S1P2 during myogenic differentiation results in the specific uncoupling of sphingosine 1-phosphate signalling to phospholipase D.. BIOCHIMICA AND BIOPHYSICA ACTA. MOLECULAR AND CELL BIOLOGY OF LIPIDS, vol. 1633, pp. 133-142, ISSN:1879-2618

E. Meacci; C.Donati; M.Farnararo; P. Bruni (2003). Sphingosine 1-phosphate signal transduction in muscle cells. ITALIAN JOURNAL OF BIOCHEMISTRY, vol. 52, pp. 25-27, ISSN:0021-2938

E.Meacci; F. Nuti; S. Catarzi; V. Vasta; C. Donati; S. Bourgoin; P. Bruni; J. Moss; M. Vaughan (2003). Activation of phospholipase D by Bradykinin and Sphingosine 1-phosphate in A549 human lung adenocarcinoma cells via different GTP-binding proteins and protein kinase C delta signaling pathways. BIOCHEMISTRY, vol. 42, pp. 284-292, ISSN:0006-2960

E.Meacci;F.Cencetti;L.Formigli;R.Squecco;C.Donati;B.Tiribilli;F. Quercioli;S.Zecchi;F.Francini;P.Bruni (2002). Sphingosine 1-phosphate evokes calcium signals in C2C12 myoblasts via Edg3 and Edg5 receptors.. BIOCHEMICAL JOURNAL, vol. 362, pp. 349-357, ISSN:0264-6021

E. Meacci; L.Becciolini;F.Nuti; C.Donati; F. Cencetti; M. Farnararo; P. Bruni (2002). A role for calcium in sphingosine 1-phosphate-induced phospholipase D activity in C2C12 myoblasts. FEBS LETTERS, vol. 521, pp. 200-204, ISSN:0014-5793

E. MEACCI; C. DONATI; F. CENCETTI; M. FARNARARO; P. BRUNI (2001). DUAL REGULATION OF SPHINGOSINE 1-PHOSPHATE-INDUCED PHOSPHOLIPASE D ACTIVITY THROUGH RHOA AND PROTEIN KINASE C-ALPHA IN C2C12 MYOBLASTS. CELLULAR SIGNALLING, vol. 13, pp. 593-598, ISSN:0898-6568

Donati, Chiara; Cencetti, Francesca; Romiti, E.; Bruni, Paola (2000). Permissive role of protein kinase C alfa but not protein kinase C delta in sphingosine 1-phosphate-induced RhoA activation in C2C12 myoblasts. FEBS Lett. (2000) 482, 97-101. FEBS LETTERS, vol. 482, pp. 97-101, ISSN:0014-5793

V. VASTA; E. MEACCI; S. CATARZI; M. FARNARARO; C. DONATI; P. BRUNI (2000). SPHINGOSINE-1-PHOSPHATE INDUCES ARACHIDONIC ACID MOBILIZATION IN A549 HUMAN LUNG ADENOCARCINOMA CELLS. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, vol. 1483, pp. 154-160, ISSN:0005-2736

E. Meacci; C. Donati; F. Cencetti; E. Romiti; P. Bruni (2000). Permissive role of protein kinase C alfa but not protein kinase C delta in sphingosine 1-phosphate-induced RhoA activation in C2C12 myoblasts.. FEBS LETTERS, vol. 482, pp. 97-101, ISSN:0014-5793

MEACCI E.; DONATI C; CENCETTI F.; ROMITI E.; M. FARNARARO; BRUNI P. (2000). Receptor-activated phospholipase D is present in caveolin-3-enriched light membranes of C2C12 myotubes.. FEBS LETTERS, vol. 473, pp. 10-14, ISSN:0014-5793

E.MEACCI; V.VASTA; C.DONATI; M.FARNARARO; P. BRUNI (1999). Receptor-mediated activation of phospholipase D by sphingosine 1-phosphate in skeletal muscle C2C12 cells. A role for protein kinase C.. FEBS LETTERS, vol. 457, pp. 184-188, ISSN:0014-5793

Chiara DONATI

Biography

1998 Biological Sciences degree

2002 Residency in Clinical Biochemistry.

2006 PhD in Biochemistry and Applied Biology.

2004 Researcher (BIO/13)

2015 Associate professor (BIO/13)

2024 Full professor (BIOS10/A)

Chiara DONATI

Curriculum

Education

1993-1998 University of Florence (Italy). Degree granted: Laurea in Biological Sciences

Thesis: Regulation of phospholipase D (PLD) by G-protein coupled agonists in muscle satellite cells C2C12.

1998-2002 Residency in Clinical Biochemistry at the University of Florence, Italy

2003-2005 Ph. D. in Biochemical Sciences and Applied Biology at the University of Florence, Italy

Employment

2004-2015 Researcher (SSD BIO/ 13) at the Department of Experimental, Clinical and Biomedical Sciences "M.Serio" of the University of Florence.

2015 Associate professor (SSD BIO/13) at the Department of Experimental, Clinical and Biomedical Sciences "M.Serio" of the University of Florence.

2024 Full professor (SSD BIOS-10/A) at the Department of Experimental, Clinical and Biomedical Sciences "M.Serio" of the University of Florence.

Honours

1996 Undergraduate short-term Erasmus fellowship spent at the King's College of London (UK).

1998-2000 Telethon post-graduate fellowship at the Department of Biochemical Sciences, University of Florence.

2000 Post-graduate fellowship (Ente Cassa di Risparmio di Firenze) at the Department of Biochemical Sciences, University of Florence.

2000-2002 Visiting fellow at the National Institutes of Health of Bethesda (Md, USA)

Academic achievements

Teacher of the course of Biology, Dentistry and Psychology.

Chiara DONATI

Interest

· Characterization of the role of bioactive metabolites of sphingomyelin catabolism, in particular sphingosine 1-phosphate, in the regeneration of skeletal muscle and related physiological control mechanisms.

· Characterization of the role of bioactive metabolites of sphingomyelin catabolism, in particular sphingosine 1-phosphate, in the regulation of fundamental biological processes such as proliferation, differentiation, survival, migration of mesenchymal stem cells such as mesoangioblasts and mesenchymal stem cells derived from adipose tissue and otic vesicle progenitors.

· Characterization of the physiological role and the molecular mechanisms of the functional cross-talk between sphingolipid and cytokine (TNFa, TGFb) and growth factor (IGF-1, Insulin, PDGF) signalling in the biology of resident stem cells of skeletal muscle and mesenchymal progenitors.

· Characterization of the role of sphingosine 1-phosphate, its metabolism and its receptors in the functional interaction between glial and neuronal cells following treatment with beta amyloid oligomers and alpha-synuclein.

Characterization of the role of sphingosine 1-phosphate, its metabolism and its receptors in benign uterin disorders such as endometriosis, adenomyosis and uterine fibroids.

Characterization of the role of sphingosine 1-phosphate, its metabolism and its receptors in exosome mediated communication in obesity associated-male infertility.

Chiara DONATI

Note

Member of the National University Council (CUN) area 05 associate professors, Biological Sciences, from May 2019 to April 2023.

Member of the Presidio di Qualità di Ateneo (PQA), University of Florence, since July 1, 2023.

Member of the Commissione di indirizzo e autovalutazione (CIA) of the Department of Experimental and Clinical Biomedical Sciences "Mario Serio," University of Florence, from 2021 to 2023.

Member of the Board of the Italian Association of General and Molecular Biology and Genetics (AIBG) from 2019 to 2021.

Currently Secretary/Treasurer of the Italian Association of General and Molecular Biology and Genetics (AIBG) since January 2023.

Since 2017, she has been a member of the Faculty Board of the PhD program in Biochemistry and Molecular Biology - BIBIM2.0, University of Siena.

Area riservata