Personale

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Orario di ricevimento

Italiano

Curriculum

Pubblicazioni

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English

Curriculum

Elena RAPIZZI

Ruolo attuale:: Professore Associato
SSD:: MEDS-02/B - Patologia clinica
Afferenza organizzativa:: Dipartimento di Medicina Sperimentale e Clinica

Recapiti

	0552758245
	elena.rapizzi(AT)unifi.it

Ulteriori Recapiti

	Viale Pieraccini 6, Cubo 2, primo piano, stanza 1/078, 50139, Firenze
	0552758245

Elena RAPIZZI

Curriculum

ISTRUZIONE E FORMAZIONE

2014 - Firenze - Università degli Studi di Firenze – Laurea Magistrale in Scienze dell'Alimentazione (LM-61) 110/110 e Lode

2000 - Padova - Università di Padova - Dottorato di ricerca in Reumatologia Sperimentale (Ciclo XII)

1996 - Padova - Università degli Studi di Padova - Abilitazione alla professione di Biologo

1994 - Padova - Università di Padova – Laurea V.O. in Scienze Biologiche

ESPERIENZA PROFESSIONALE

2024-presente Professore Associato. Università degli Studi di Firenze, Dipartimento di Medicina Sperimentale e Clinica

2021-2024 RTDb (percorso ricercatore senior). Università degli Studi di Firenze, Dipartimento di Medicina Sperimentale e Clinica

2020-2021 RDTa. Università degli Studi di Firenze, Dipartimento di Medicina Sperimentale e Clinica

2016-2020 Borsa o assegno di ricerca post-dottorato. Università degli Studi di Firenze, Dipartimento di Medicina Sperimentale e Clinica

2011-2016 Borsa o assegno di ricerca post-dottorato. Università degli Studi di Firenze, Dipartimento di Scienze Biomediche Sperimentali e Cliniche

2010-2011 Assegno di ricerca post-dottorato. Università degli Studi di Firenze, Dipartimento di Fisiopatologia Clinica

2004-2008 Assegno di ricerca. Università degli Studi di Firenze, Dipartimento di Biochimica

2001-2003 Ricercatore presso l’Università del Massachusetts Medical School, Department of Program in Molecular Medicine, Worcester, MA, USA

2001-2003 Borsa di ricerca post-dottorato finanziata dalla Fondazione Telethon per attività all’estero. Svolta presso l’Università del Massachusetts Medical School, Department of Program in Molecular Medicine, Worcester, MA, USA

2000-2001 Borsa di ricerca post-dottorato. Università degli Studi di Ferrara, Dipartimento di Medicina Sperimentale e Diagnostica

1999-2000 Borsa di ricerca. Università degli Studi di Ferrara, Dipartimento di Medicina Sperimentale e Diagnostica

1996-1999 Dottorato di ricerca (Ciclo XII) in Reumatologia Sperimentale. Università di Padova, Dipartimento di Reumatologia

1995-1996 Borsa di studio post-laurea. Università di Padova, Dipartimento di Scienze Biomediche Sperimentali

CONTRIBUTO SCIENTIFICO

La sua produzione scientifica conta ad oggi 75 manoscritti originali su riviste internazionali peer-reviewed, H-index=30 (fonte Scopus)

INTERESSE SCIENCENTIFICO

Il suo interesse scientifico si concentra sullo studio del microambiente tumorale. In particolare, sulle interazioni tra cellule non tumorali, quali fibroblasti e cellule endoteliali, e cellule tumorali al fine di comprendere meglio i meccanismi molecolari alla base della tumorigenesi, della crescita e della progressione tumorale

Elena RAPIZZI

Pubblicazioni

Legenda

Contributo su rivista |

Articolo su libro |

Libro |

Contributo in atti di convegno (proceeding) |

Brevetto |

Curatela | Altro

Altro |

Tesi di Dottorato

Pepponi, Miriam; Berti, Valentina; Fasciglione, Elsa; Montanini, Flavio; Canu, Letizia; Hubele, Fabrice; Abenavoli, Elisabetta; Briganti, Vittorio; Rapizzi, Elena; Charpiot, Anne; Taieb, David; Pacak, Karel; Goichot, Bernard; Imperiale, Alessio (2024). [68Ga]DOTATOC PET-derived radiomics to predict genetic background of head and neck paragangliomas: a pilot investigation. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, pp. 0-0, ISSN:1619-7070 DOI

Canu, Letizia; Sparano, Clotilde; Naletto, Lara; De Filpo, Giuseppina; Cantini, Giulia; Rapizzi, Elena; Martinelli, Serena; Ercolino, Tonino; Cioppi, Francesca; Fantoni, Alessandro; Zanatta, Lorenzo; Terreni, Alessandro; Mannelli, Massimo; Luconi, Michaela; Maggi, Mario; Lotti, Francesco (2024). Hypogonadism and sexual function in men affected by adrenocortical carcinoma under mitotane therapy. FRONTIERS IN ENDOCRINOLOGY, vol. 14, pp. 0-0, ISSN:1664-2392 DOI

Serena Martinelli, Giulia Cantini, Arianna Pia Propato, Daniele Bani, Daniele Guasti, Patrizia Nardini, Laura Calosi, Tommaso Mello, Nicole Bechmann, Giovanna Danza, Fabio Villanelli, Letizia Canu, Mario Maggi, Massimo Mannelli, Elena Rapizzi, Michaela Luconi (2024). The 3D in vitro Adrenoid cell model recapitulates the complexity of the adrenal gland. SCIENTIFIC REPORTS, vol. 14, pp. ...-..., ISSN:2045-2322 DOI

Monteagudo, María; Calsina, Bruna; Salazar-Hidalgo, Milton E; Martínez-Montes, Ángel M; Piñeiro-Yáñez, Elena; Caleiras, Eduardo; Martín, Maria Carmen; Rodríguez-Perales, Sandra; Letón, Rocío; Gil, Eduardo; Buffet, Alexandre; Burnichon, Nelly; Fernández-Sanromán, Ángel; Díaz-Talavera, Alberto; Mellid, Sara; Arroba, Ester; Reglero, Clara; Martínez-Puente, Natalia; Roncador, Giovanna; Del Olmo, Maria Isabel; Corrales, Pedro José Pinés; Oliveira, Cristina Lamas; Álvarez-Escolá, Cristina; Gutiérrez, María Calatayud; López-Fernández, Adrià; García, Nuria Palacios; Regojo, Rita María; Díaz, Luis Robles; Laorden, Nuria Romero; Guadarrama, Oscar Sanz; Bechmann, Nicole; Beuschlein, Felix; Canu, Letizia; Eisenhofer, Graeme; Fassnacht, Martin; Nölting, Svenja; Quinkler, Marcus; Rapizzi, Elena; Remde, Hanna; Timmers, Henri J; Favier, Judith; Gimenez-Roqueplo, Anne-Paule; Rodriguez-Antona, Cristina; Currás-Freixes, Maria; Al-Shahrour, Fatima; Cascón, Alberto; Leandro-García, Luis J; Montero-Conde, Cristina; Robledo, Mercedes (2024). MAML3-fusions modulate vascular and immune tumour microenvironment and confer high metastatic risk in pheochromocytoma and paraganglioma. BEST PRACTICE & RESEARCH. CLINICAL ENDOCRINOLOGY & METABOLISM, pp. 1-19, ISSN:1878-1594 DOI

Rapizzi, Elena; Abate, Andrea; Tamburello, Mariangela; Luconi, Michaela; Sigala, Sandra (2024). Preclinic and Translational Research in Adrenal Malignancies. In: Elena Rapizzi, Andrea Abate, Mariangela Tamburello, Michaela Luconi, Sandra Sigala. Primary Adrenal Malignancies. Updates in Surgery, pp. 167-176 G.A.M. Tiberio, ISBN:9783031623004. DOI

Li, Minghao; Richter, Susan; Mohr, Hermine; Drukewitz, Stephan; Poser, Isabel; Stanke, Daniela; Calsina, Bruna; Martinez-Montes, Angel M; Quinkler, Marcus; Timmers, Henri Jlm; Nölting, Svenja; Beuschlein, Felix; Remde, Hanna; Opocher, Giuseppe; Rapizzi, Elena; Pacak, Karel; Pamporaki, Christina; Robledo, Mercedes; Liu, Longfei; Jiang, Jingjing; Bornstein, Stefan R; Eisenhofer, Graeme; Fliedner, Stephanie M J; Bechmann, Nicole (2023). Regulation of epinephrine biosynthesis in HRAS-mutant paragangliomas. ENDOCRINE-RELATED CANCER, pp. 0-0, ISSN:1351-0088 DOI

Calsina, Bruna; Piñeiro-Yáñez, Elena; Martínez-Montes, Ángel M; Caleiras, Eduardo; Fernández-Sanromán, Ángel; Monteagudo, María; Torres-Pérez, Rafael; Fustero-Torre, Coral; Pulgarín-Alfaro, Marta; Gil, Eduardo; Letón, Rocío; Jiménez, Scherezade; García-Martín, Santiago; Martin, Maria Carmen; Roldán-Romero, Juan María; Lanillos, Javier; Mellid, Sara; Santos, María; Díaz-Talavera, Alberto; Rubio, Ángeles; González, Patricia; Hernando, Barbara; Bechmann, Nicole; Dona, Margo; Calatayud, María; Guadalix, Sonsoles; Álvarez-Escolá, Cristina; Regojo, Rita M; Aller, Javier; Del Olmo-Garcia, Maria Isabel; López-Fernández, Adrià; Fliedner, Stephanie M J; Rapizzi, Elena; Fassnacht, Martin; Beuschlein, Felix; Quinkler, Marcus; Toledo, Rodrigo A; Mannelli, Massimo; Timmers, Henri J; Eisenhofer, Graeme; Rodríguez-Perales, Sandra; Domínguez, Orlando; Macintyre, Geoffrey; Currás-Freixes, Maria; Rodríguez-Antona, Cristina; Cascón, Alberto; Leandro-García, Luis J; Montero-Conde, Cristina; Roncador, Giovanna; García-García, Juan Fernando; Pacak, Karel; Al-Shahrour, Fátima; Robledo, Mercedes (2023). Genomic and immune landscape Of metastatic pheochromocytoma and paraganglioma. NATURE COMMUNICATIONS, vol. 14, pp. 1122-1130, ISSN:2041-1723 DOI

De Filpo, Giuseppina; Parenti, Gabriele; Sparano, Clotilde; Rastrelli, Giulia; Rapizzi, Elena; Martinelli, Serena; Amore, Francesca; Badii, Benedetta; Paolo, Prosperi; Ercolino, Tonino; Mannelli, Massimo; Maggi, Mario; Canu, Letizia (2023). Hemodynamic parameters in patients undergoing surgery for pheochromocytoma/paraganglioma: a retrospective study. WORLD JOURNAL OF SURGICAL ONCOLOGY, vol. 21, pp. 192-192, ISSN:1477-7819 DOI

Buonvicino, Daniela; Ranieri, Giuseppe; Guasti, Daniele; Pistolesi, Alessandra; La Rocca, Antonino Iurato; Rapizzi, Elena; Chiarugi, Alberto (2023). Early derangement of axonal mitochondria occurs in a mouse model of progressive but not relapsing-remitting multiple sclerosis. NEUROBIOLOGY OF DISEASE, vol. 178, pp. 106015-106019, ISSN:0969-9961 DOI

Cellai, Ilaria; Comeglio, Paolo; Filippi, Sandra; Martinelli, Serena; Villanelli, Fabio; Amore, Francesca; Rapizzi, Elena; Maseroli, Elisa; Cipriani, Sarah; Raddi, Chiara; Guarnieri, Giulia; Sarchielli, Erica; Danza, Giovanna; Morelli, Annamaria; Rastrelli, Giulia; Maggi, Mario; Vignozzi, Linda (2023). The regulatory effect of sex steroids on the RhoA/ROCK pathway in the rat distal vagina. THE JOURNAL OF SEXUAL MEDICINE, vol. 20, pp. 1-13, ISSN:1743-6109 DOI

Martinelli, Serena; Amore, Francesca; Canu, Letizia; Maggi, Mario; Rapizzi, Elena (2023). Tumour microenvironment in pheochromocytoma and paraganglioma. FRONTIERS IN ENDOCRINOLOGY, vol. 14, pp. 1137456-1137456, ISSN:1664-2392 DOI

Amore, Francesca; Garella, Rachele; Santi, Alice; Guasti, Daniele; Martinelli, Serena; Canu, Letizia; Bani, Daniele; Neuzil, Jiri; Maggi, Mario; Squecco, Roberta; Rapizzi, Elena (2023). The aggressiveness of succinate dehydrogenase subunit B-deficient chromaffin cells is reduced when their bioelectrical properties are restored by glibenclamide. ENDOCRINE-RELATED CANCER, vol. 30, pp. 0-0, ISSN:1351-0088 DOI

Martinelli, Serena; Riverso, Maria; Mello, Tommaso; Amore, Francesca; Parri, Matteo; Simeone, Irene; Mannelli, Massimo; Maggi, Mario; Rapizzi, Elena (2022). SDHB and SDHD silenced pheochromocytoma spheroids respond differently to tumour microenvironment and their aggressiveness is inhibited by impairing stroma metabolism. MOLECULAR AND CELLULAR ENDOCRINOLOGY, vol. 547, pp. 111594-111604, ISSN:0303-7207 DOI

Martinelli, Serena; Amore, Francesca; Mello, Tommaso; Mannelli, Massimo; Maggi, Mario; Rapizzi, Elena (2022). Metformin Treatment Induces Different Response in Pheochromocytoma/Paraganglioma Tumour Cells and in Primary Fibroblasts. CANCERS, vol. 14, pp. 3471-3487, ISSN:2072-6694 DOI

Cipriani, Sarah; Cellai, Ilaria; Comeglio, Paolo; Filippi, Sandra; Martinelli, Serena; Rapizzi, Elena; Maseroli, Elisa; Sarchielli, Erica; Guarnieri, Giulia; Morelli, Annamaria; Rastrelli, Giulia; Maggi, Mario; Vignozzi, Linda (2022). Distal vagina smooth muscle contractility mechanisms: effects of in vivo sex steroids treatment in an animal experimental model of ovariectomy. THE JOURNAL OF SEXUAL MEDICINE, vol. 19, pp. 30-30, ISSN:1743-6109 DOI Accesso ONLINE all'editore

Mellid, Sara; Gil, Eduardo; Letón, Rocío; Caleiras, Eduardo; Honrado, Emiliano; Richter, Susan; Palacios, Nuria; Lahera, Marcos; Galofré, Juan C; López-Fernández, Adriá; Calatayud, Maria; Herrera-Martínez, Aura D; Galvez, María A; Matias-Guiu, Xavier; Balbín, Milagros; Korpershoek, Esther; Lim, Eugénie S; Maletta, Francesca; Lider, Sofia; Fliedner, Stephanie M J; Bechmann, Nicole; Eisenhofer, Graeme; Canu, Letizia; Rapizzi, Elena; Bancos, Irina; Robledo, Mercedes; Cascón, Alberto (2022). Co-occurrence of mutations in NF1 and other susceptibility genes in pheochromocytoma and paraganglioma. FRONTIERS IN ENDOCRINOLOGY, vol. 13, pp. 1070074-1070078, ISSN:1664-2392 DOI

Provenzano, Aldesia; Chetta, Massimiliano; De Filpo, Giuseppina; Cantini, Giulia; La Barbera, Andrea; Nesi, Gabriella; Santi, Raffaella; Martinelli, Serena; Rapizzi, Elena; Luconi, Michaela; Maggi, Mario; Mannelli, Massimo; Ercolino, Tonino; Canu, Letizia (2022). Novel Germline PHD2 Variant in a Metastatic Pheochromocytoma and Chronic Myeloid Leukemia, but in the Absence of Polycythemia. MEDICINA, vol. 58, pp. 0-0, ISSN:1010-660X DOI

E Maseroli, P Comeglio, C Corno, I Cellai, S Filippi, T Mello, A Galli, E Rapizzi, L Presenti, M C Truglia, F Lotti, E Facchiano, B Beltrame, M Lucchese, F Saad, G Rastrelli, M Maggi, L Vignozzi (2021). Testosterone treatment is associated with reduced adipose tissue dysfunction and nonalcoholic fatty liver disease in obese hypogonadal men. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, vol. 44, pp. 819-842, ISSN:1720-8386 DOI

Canu L.; Puglisi S.; Berchialla P.; De Filpo G.; Brignardello F.; Schiavi F.; Ferrara A.M.; Zovato S.; Luconi M.; Pia A.; Appetecchia M.; Arvat E.; Letizia C.; Maccario M.; Parasiliti-Caprino M.; Altieri B.; Faggiano A.; Modica R.; Morelli V.; Arosio M.; Verga U.; Pellegrino M.; Petramala L.; Concistre A.; Razzore P.; Ercolino T.; Rapizzi E.; Maggi M.; Stigliano A.; Burrello J.; Terzolo M.; Opocher G.; Mannelli M.; Reimondo G. (2021). A multicenter epidemiological study on second malignancy in non-syndromic pheochromocytoma/paraganglioma patients in Italy. CANCERS, vol. 13, pp. 5831-5845, ISSN:2072-6694 DOI

Dwight T.; Kim E.; Bastard K.; Benn D.E.; Eisenhofer G.; Richter S.; Mannelli M.; Rapizzi E.; Prejbisz A.; Peczkowska M.; Pacak K.; Clifton-Bligh R. (2021). Functional significance of germline EPAS1 variants. ENDOCRINE-RELATED CANCER, vol. 28, pp. 97-109, ISSN:1351-0088 DOI

Monteagudo M.; Martinez P.; Leandro-Garcia L.J.; Martinez-Montes A.M.; Calsina B.; Pulgarin-Alfaro M.; Diaz-Talavera A.; Mellid S.; Leton R.; Gil E.; Perez-Martinez M.; Megias D.; Torres-Ruiz R.; Rodriguez-Perales S.; Gonzalez P.; Caleiras E.; Jimenez-Villa S.; Roncador G.; Alvarez-Escola C.; Regojo R.M.; Calatayud M.; Guadalix S.; Curras-Freixes M.; Rapizzi E.; Canu L.; Nolting S.; Remde H.; Fassnacht M.; Bechmann N.; Eisenhofer G.; Mannelli M.; Beuschlein F.; Quinkler M.; Rodriguez-Antona C.; Cascon A.; Blasco M.A.; Montero-Conde C.; Robledo M. (2021). Analysis of telomere maintenance related genes reveals NOP10 as a new metastatic-risk marker in pheochromocytoma/paraganglioma. CANCERS, vol. 13, pp. 4758-4779, ISSN:2072-6694 DOI

Dona, Margo; Waaijers, Selma; Richter, Susan; Eisenhofer, Graeme; Korving, Jeroen; Kamel, Sarah M; Bakkers, Jeroen; Rapizzi, Elena; Rodenburg, Richard J; Zethof, Jan; Gorissen, Marnix; Flik, Gert; Deen, Peter M T; Timmers, Henri Jlm (2020). Loss of sdhb in zebrafish larvae recapitulates human paraganglioma characteristics. ENDOCRINE-RELATED CANCER, pp. 0-0, ISSN:1351-0088 DOI

Martinelli, Serena; Maggi, Mario; Rapizzi, Elena (2020). Pheochromocytoma/paraganglioma preclinical models: which to use and why?. ENDOCRINE CONNECTIONS, pp. 0-0, ISSN:2049-3614 DOI

Wallace P.W.; Conrad C.; Bruckmann S.; Pang Y.; Caleiras E.; Murakami M.; Korpershoek E.; Zhuang Z.; Rapizzi E.; Kroiss M.; Gudziol V.; Timmers H.J.L.M.; Mannelli M.; Pietzsch J.; Beuschlein F.; Pacak K.; Robledo M.; Klink B.; Peitzsch M.; Gill A.J.; Tischler A.S.; de Krijger R.R.; Papathomas T.; Aust D.; Eisenhofer G.; Richter S. (2020). Metabolomics, machine learning and immunohistochemistry to predict succinate dehydrogenase mutational status in phaeochromocytomas and paragangliomas. JOURNAL OF PATHOLOGY, vol. 251, pp. 378-387, ISSN:0022-3417 DOI

De Filpo G, Contini E, Serio V, Valeri A, Chetta M, Guasti D, Bani D, Mannelli M, Rapizzi E, Luconi M, Maggi M, Ercolino T, Canu L. (2020). Germline Mutation in KIF1Bβ Gene Associated with Loss of Heterozygosity: Usefulness of Next-Generation Sequencing in the Genetic Screening of Patients with Pheochromocytoma. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, vol. 2020, pp. 3671396--, ISSN:1687-8345 DOI

Rapizzi E, Benvenuti S, Deledda C, Martinelli S, Sarchielli E, Fibbi B, Luciani P, Mazzanti B, Pantaleo M, Marroncini G, Vannelli GB, Maggi M, Mannelli M, Luconi M, Peri A. (2020). A unique neuroendocrine cell model derived from the human foetal neural crest.. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, vol. 43, pp. 1259-1269, ISSN:1720-8386 DOI

Sarchielli E, Comeglio P, Filippi S, Cellai I, Guarnieri G, Guasti D, Rapizzi E, Rastrelli G, Bani D, Vannelli GB, Vignozzi L, Morelli A, Maggi M (2020). Testosterone improves muscle fiber asset and exercise performance in a metabolic syndrome model.. JOURNAL OF ENDOCRINOLOGY, vol. 245, pp. 259-279, ISSN:0022-0795 DOI

Pranzini E.; Leo A.; Rapizzi E.; Ramazzotti M.; Magherini F.; Giovannelli L.; Caselli A.; Cirri P.; Taddei M.L.; Paoli P. (2019). miR-210-3p mediates metabolic adaptation and sustains DNA damage repair of resistant colon cancer cells to treatment with 5-fluorouracil. MOLECULAR CARCINOGENESIS, vol. 58, pp. 1-12, ISSN:1098-2744 DOI Accesso ONLINE all'editore

Ippolito, Luigi; Morandi, Andrea; Taddei, Maria Letizia; Parri, Matteo; Comito, Giuseppina; Iscaro, Alessandra; Raspollini, Maria Rosaria; Magherini, Francesca; Rapizzi, Elena; Masquelier, Julien; Muccioli, Giulio G; Sonveaux, Pierre; Chiarugi, Paola; Giannoni, Elisa (2019). Cancer-associated fibroblasts promote prostate cancer malignancy via metabolic rewiring and mitochondrial transfer. ONCOGENE, vol. 38, pp. 5339-5355, ISSN:0950-9232 DOI Accesso ONLINE all'editore

Richter S.; Gieldon L.; Pang Y.; Peitzsch M.; Huynh T.; Leton R.; Viana B.; Ercolino T.; Mangelis A.; Rapizzi E.; Menschikowski M.; Aust D.; Kroiss M.; Beuschlein F.; Gudziol V.; Timmers H.J.; Lenders J.; Mannelli M.; Cascon A.; Pacak K.; Robledo M.; Eisenhofer G.; Klink B. (2019). Metabolome-guided genomics to identify pathogenic variants in isocitrate dehydrogenase, fumarate hydratase, and succinate dehydrogenase genes in pheochromocytoma and paraganglioma. GENETICS IN MEDICINE, vol. 21, pp. 705-717, ISSN:1098-3600 DOI

Comeglio, Paolo; Cellai, Ilaria; Mello, Tommaso; Filippi, Sandra; Maneschi, Elena; Corcetto, Francesca; Corno, Chiara; Sarchielli, Erica; Morelli, Annamaria; Rapizzi, Elena; Bani, Daniele; Guasti, Daniele; Vannelli, Gabriella Barbara; Galli, Andrea; Adorini, Luciano; Maggi, Mario; Vignozzi, Linda (2018). INT-767 prevents NASH and promotes visceral fat brown adipogenesis and mitochondrial function. JOURNAL OF ENDOCRINOLOGY, vol. 238, pp. 107-127-127, ISSN:0022-0795 DOI Accesso ONLINE all'editore

Mannelli, Massimo*; Canu, Letizia; Ercolino, Tonino; Rapizzi, Elena; Martinelli, Serena; Parenti, Gabriele; De Filpo, Giuseppina; Nesi, Gabriella (2018). DIAGNOSIS of ENDOCRINE DISEASE: SDHx mutations: Beyond pheochromocytomas and paragangliomas. EUROPEAN JOURNAL OF ENDOCRINOLOGY, vol. 178, pp. R11-R17, ISSN:0804-4643 DOI Accesso ONLINE all'editore

Richter S.; D'Antongiovanni V.; Martinelli S.; Bechmann N.; Riverso M.; Poitz D.M.; Pacak K.; Eisenhofer G.; Mannelli M.; Rapizzi E. (2018). Primary fibroblast co-culture stimulates growth and metabolism in Sdhb-impaired mouse pheochromocytoma MTT cells. CELL AND TISSUE RESEARCH, vol. 374, pp. 473-485, ISSN:0302-766X DOI

Calsina B.; Curras-Freixes M.; Buffet A.; Pons T.; Contreras L.; Leton R.; Comino-Mendez I.; Remacha L.; Calatayud M.; Obispo B.; Martin A.; Cohen R.; Richter S.; Balmana J.; Korpershoek E.; Rapizzi E.; Deutschbein T.; Vroonen L.; Favier J.; de Krijger R.R.; Fassnacht M.; Beuschlein F.; Timmers H.J.; Eisenhofer G.; Mannelli M.; Pacak K.; Satrustegui J.; Rodriguez-Antona C.; Amar L.; Cascon A.; Dolker N.; Gimenez-Roqueplo A.-P.; Robledo M. (2018). Role of MDH2 pathogenic variant in pheochromocytoma and paraganglioma patients. GENETICS IN MEDICINE, vol. 20, pp. 1652-1662, ISSN:1098-3600 DOI

Mannelli, Massimo; Parenti, Gabriele; Canu, Letizia; De Filpo, Giuseppina; Rapizzi, Elena (2018). Malignant Pheochromocytoma. In: Massimo Mannelli, Gabriele Parenti, Letizia Canu, Giuseppina De Filpo, Elena Rapizzi. Encyclopedia of Endocrine Diseases, pp. 460-468 Academic Press, ISBN:9780128122006. DOI

Santi R.; Rapizzi E.; Canu L.; Ercolino T.; Baroni G.; Fucci R.; Costa G.; Mannelli M.; Nesi G. (2017). Potential pitfalls of SDH immunohistochemical detection in paragangliomas and phaeochromocytomas harbouring germline SDHx gene mutation. ANTICANCER RESEARCH, vol. 37, pp. 805-812, ISSN:0250-7005 DOI

D'Antongiovanni, Vanessa; Martinelli, Serena; Richter, Susan; Canu, Letizia; Guasti, Daniele; Mello, Tommaso; Romagnoli, Paolo; Pacak, Karel; Eisenhofer, Graeme; Mannelli, Massimo; Rapizzi, Elena (2017). The microenvironment induces collective migration in SDHB-silenced mouse pheochromocytoma spheroids. ENDOCRINE-RELATED CANCER, vol. 24, pp. 555-564, ISSN:1351-0088 DOI

Canu L.; Pradella S.; Rapizzi E.; Fucci R.; Valeri A.; Briganti V.; Giache V.; Parenti G.; Ercolino T.; Mannelli M. (2017). Sunitinib in the therapy of malignant paragangliomas: Report on the efficacy in a sdhb mutation carrier and review of the literature. ARCHIVES OF ENDOCRINOLOGY AND METABOLISM, vol. 61, pp. 90-97, ISSN:2359-3997 DOI

Richter, S; Klink, B; Nacke, B; de Cubas, Aa; Mangelis, A; Rapizzi, E; Meinhardt, M; Skondra, C; Mannelli, M; Robledo, M; Menschikowski, M; Eisenhofer, G. (2016). Epigenetic Mutation of the Succinate Dehydrogenase C Promoter in a Patient With Two Paragangliomas.. THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, vol. 101, pp. 359-363, ISSN:0021-972X DOI

Rapizzi, Elena; Fucci, Rossella; Giannoni, Elisa; Canu, Letizia; Richter, Susan; Cirri, Paolo; Mannelli, Massimo (2015). Role of microenvironment on neuroblastoma SK-N-AS SDHB-silenced cell metabolism and function. ENDOCRINE-RELATED CANCER, vol. 22, pp. 409-417, ISSN:1351-0088 DOI Accesso ONLINE all'editore

Mannelli, Massimo; Rapizzi, Elena; Fucci, Rossella; Canu, Letizia; Ercolino, Tonino; Michaela, Luconi; Young William, F. (2015). 15 YEARS OF PARAGANGLIOMA: Metabolism and pheochromocytoma/paraganglioma. ENDOCRINE-RELATED CANCER, vol. 22, pp. 83-90, ISSN:1351-0088 DOI

Papathomas, Thomas G.; Oudijk, Lindsey; Persu, Alexandre; Gill, Anthony J.; Van Nederveen, Francien; Tischler, Arthur S.; Tissier, Frédérique; Volante, Marco; Matias-Guiu, Xavier; Smid, Marcel; Favier, Judith; Rapizzi, Elena; Libe, Rosella; Currás-Freixes, Maria; Aydin, Selda; Huynh, Thanh; Lichtenauer, Urs; Van Berkel, Anouk; Canu, Letizia; Domingues, Rita; Clifton-Bligh, Roderick J.; Bialas, Magdalena; Vikkula, Miikka; Baretton, Gustavo; Papotti, Mauro; Nesi, Gabriella; Badoual, Cécile; Pacak, Karel; Eisenhofer, Graeme; Timmers, Henri J.; Beuschlein, Felix; Bertherat, Jérôme; Mannelli, Massimo; Robledo, Mercedes; Gimenez-Roqueplo, Anne-Paule; Dinjens, Winand N.M.; Korpershoek, Esther; De Krijger, Ronald R. (2015). SDHB/SDHA immunohistochemistry in pheochromocytomas and paragangliomas: A multicenter interobserver variation analysis using virtual microscopy: A Multinational Study of the European Network for the Study of Adrenal Tumors (ENS@T). MODERN PATHOLOGY, vol. 28, pp. 807-821, ISSN:0893-3952 DOI Accesso ONLINE all'editore

S. Richter;M. Peitzsch;E. Rapizzi;J. W. Lenders;N. Qin;A. A. de;F. Schiavi;J. U. Rao;F. Beuschlein;M. Quinkler;H. J. Timmers;G. Opocher;M. Mannelli;K. Pacak;M. Robledo;G. Eisenhofer (2014). Krebs Cycle Metabolite Profiling for Identification and Stratification of Pheochromocytomas/Paragangliomas due to Succinate Dehydrogenase Deficiency.. THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, vol. 99, pp. 3903-3911, ISSN:0021-972X DOI Accesso ONLINE all'editore

Canu L;Rapizzi E;Zampetti B;Fucci R;Nesi G;Richter S;Qin N;Giach? V;Bergamini C;Parenti G;Valeri A;Ercolino T;Eisenhofer G;Mannelli M (2014). Pitfalls in Genetic Analysis of Pheochromocytomas/Paragangliomas-Case Report.. THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, vol. 99, pp. 2321-2326, ISSN:0021-972X DOI Accesso ONLINE all'editore

Rapizzi E; Ercolino T; Fucci R; Zampetti B; Felici R; Guasti D; Morandi A; Giannoni E; Giaché V; Bani D; Chiarugi A; Mannelli M (2014). Succinate dehydrogenase subunit B mutations modify human neuroblastoma cell metabolism and proliferation. HORMONES & CANCER, vol. 5(3), pp. 174-184, ISSN:1868-8497

E. Panizza;T. Ercolino;L. Mori;E. Rapizzi;M. Castellano;G. Opocher;I. Ferrero;H. P. H;M. Mannelli;P. Goffrini (2013). Yeast model for evaluating the pathogenic significance of SDHB, SDHC and SDHD mutations in PHEO-PGL syndrome.. HUMAN MOLECULAR GENETICS, vol. 22, pp. 804-815, ISSN:0964-6906 DOI Accesso ONLINE all'editore

I. Comino-Méndez;A. A. de;C. Bernal;C. Alvarez-Escolá;C. Sánchez-Malo;C. L. Ramírez-Tortosa;S. Pedrinaci;E. Rapizzi;T. Ercolino;G. Bernini;A. Bacca;R. Letón;G. Pita;M. R. Alonso;L. J. Leandro-García;A. Gómez-Graña;L. Inglada-Pérez;V. Mancikova;C. Rodríguez-Antona;M. Mannelli;M. Robledo;A. Cascón (2013). Tumoral EPAS1 (HIF2A) mutations explain sporadic pheochromocytoma and paraganglioma in the absence of erythrocytosis.. HUMAN MOLECULAR GENETICS, vol. 22, pp. 2169-2176, ISSN:0964-6906 DOI

Giada Poli; Daniele Guasti; Elena Rapizzi; Rossella Fucci; Letizia Canu; Alessandra Bandinelli; Nicoletta Cini; Daniele Bani; Massimo Mannelli; Michaela Luconi (2013). Morphofunctional effects of mitotane on mitochondria in human adrenocortical cancer cells.. ENDOCRINE-RELATED CANCER, vol. 20, pp. 537-550, ISSN:1351-0088 DOI

G. Parenti;B. Zampetti;E. Rapizzi;T. Ercolino;V. Giachè;R. Fucci;M. Mannelli (2013). Clinical relevance of phenotype/genotype correlations in the diagnosis and therapy of pheochromocytomas/paragangliomas.. THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, vol. 57, pp. 112-121, ISSN:1824-4785

Burnichon N; Cascon A; Schiavi F; Paes Morales N; Comino-Mendez I; Abermil N; Inglada-Perez L; de Cubas AA; Amar L; Barontini MB; Bernaldo de Quiros S; Bertherat J; Bignon YJ; Blok MJ; Bobisse S; Borrego S; Castellano M; Chanson P; Chiara MD; Corssmit EP; Giacche M; de Krijger RR; Ercolino T; Girerd X; Gomez-Garcia EB; Gomez-Grana A; Guilhem I; Hes F; Honrado E; Korpershoek E; Lenders JW; Leton R; Mensenkamp AR; Merlo A; Mori L; Murat A; Pierre P; Plouin PF; Prodanov T; Quesada-Charneco M; Qin N; Rapizzi E; Raymond V; Reisch N; Roncador G; Ruiz-Ferrer M; Schillo F; Stegmann AP; Suarez C; Taschin E; Timmers HJ; Tops C; Urioste M; Beuschlein F; Pacak K; Mannelli M; Dahia PL; Opocher G; Eisenhofer G; Gimenez-Roqueplo AP; Robledo M (2012). MAX mutations cause hereditary and sporadic pheochromocytoma and paraganglioma. CLINICAL CANCER RESEARCH, vol. 18, pp. 2828-2837, ISSN:1078-0432

G. Parenti;B. Zampetti;E. Rapizzi;T. Ercolino;V. Giachè;M. Mannelli (2012). Updated and new perspectives on diagnosis, prognosis, and therapy of malignant pheochromocytoma/paraganglioma.. JOURNAL OF ONCOLOGY, vol. 2012, pp. ....-...., ISSN:1687-8469 DOI Accesso ONLINE all'editore

V. Ramundo;T. Ercolino;A. Faggiano;V. Giachè;B. Ragghianti;E. Rapizzi;A. Colao;M. Mannelli (2012). Genetic-clinical profile of subjects with apparently sporadic extra-adrenal paragangliomas.. FRONTIERS IN ENDOCRINOLOGY, vol. 3, pp. 65-70, ISSN:1664-2392 DOI Accesso ONLINE all'editore

V. Piccini;E. Rapizzi;A. Bacca;G. D. Trapani;R. Pulli;V. Giache;B. Zampetti;E. Lucci-Cordisco;L. Canu;E. Corsini;A. Faggiano;L. Deiana;D. Carrara;V. Tantardini;S. Mariotti;M. R. Ambrosio;M. C. Zatelli;G. Parenti;A. Colao;C. Pratesi;G. Bernini;T. Ercolino;M. Mannelli (2012). Head and neck paragangliomas: genetic spectrum and clinical variability in 79 consecutive patients. ENDOCRINE-RELATED CANCER, vol. 19, pp. 149-155, ISSN:1351-0088 DOI

Rapizzi E; Ercolino T; Canu L; Giachè V; Francalanci M; Pratesi C; Valeri A; Mannelli M (2012). Mitochondrial function and content in Pheochromocytoma/paraganglioma of succinate dehydrogenase mutation carriers. ENDOCRINE-RELATED CANCER, vol. 19, pp. 261-269, ISSN:1351-0088

A. Lapucci; M. Pittelli; E. Rapizzi; R. Felici; F. Moroni; A. Chiarugi (2011). Poly(ADP-ribose) polymerase-1 is a nuclear epigenetic regulator of mitochondrial DNA repair and transcription. MOLECULAR PHARMACOLOGY, vol. 79, pp. 932-940, ISSN:0026-895X DOI

Yao L; Schiavi F; Cascon A; Qin Y; Inglada-Pérez L; King EE; Toledo RA; Ercolino T; Rapizzi E;. Ricketts CJ; Mori L; Giacchè M; Mendola A; Taschin E; Boaretto F; Loli P; Iacobone M; Rossi GP; Biondi B; Lima-Junior JV; Kater CE; Bex M; Vikkula M; Grossman AB; Gruber SB; Barontini M; Persu A; Castellano M; Toledo SPA; Maher ER; Mannelli M; Opocher G; Robledo M; Dahia PLM (2010). Spectrum and prevalence of FP/TMEM127 gene mutations in pheochromocytomas and paragangliomas. JAMA, vol. 304, pp. 2611-2619, ISSN:0098-7484

M. Mannelli; G. Cantini; G. Poli; M. Mangoni; G. Nesi; L. Canu; E. Rapizzi; E. Borgogni; T. Ercolino; V. Piccini; M. Luconi (2010). The role of PPAR-γ system in normal and tumoral corticotroph pituitary and adrenal cells.. NEUROENDOCRINOLOGY, vol. 1 suppl, pp. 23-27, ISSN:0028-3835 DOI

M. Pittelli; L. Formentini; G. Faraco; A. Lapucci; E. Rapizzi; F. Cialdai; G. Romano; G. Moneti; F. Moroni; A. Chiarugi (2010). Inhibition of nicotinamide phosphoribosyltransferase: cellular bioenergetics reveals a mitochondrial insensitive NAD pool. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, pp. 34106-34114, ISSN:1067-8816 DOI Accesso ONLINE all'editore

E.Rapizzi; M.L.Taddei; T.Fiaschi; C.Donati; P. Bruni; P. Chiarugi (2009). Sphingosine 1-phosphate increases glucose uptake through trans-activation of insulin receptor.. CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 66, pp. 3207-3218, ISSN:1420-682X Accesso ONLINE all'editore

C.Donati; F.Cencetti; C.De Palma; E.Rapizzi; S.Brunelli; G.Cossu; E.Clementi; P.Bruni (2009). TGFbeta protects mesoangioblasts from apoptosis via sphingosine kinase-1 regulation.. CELLULAR SIGNALLING, vol. 21, pp. 228-236, ISSN:0898-6568

L. Formentini; A. Macchiarulo; G. Cipriani; E. Camaioni; E. Rapizzi; R. Pellicciari; F. Moroni; A. Chiarugi (2009). Poly(ADP-ribose) catabolism triggers AMP-dependent mitochondrial energy failure. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 284, pp. 17668-17679, ISSN:1067-8816

E.Rapizzi; C. Donati; F.Cencetti; P.Nincheri; P. Bruni (2008). Sphingosine 1-phosphate differentially regulates proliferation of C2C12 reserve cells and myoblasts. MOLECULAR AND CELLULAR BIOCHEMISTRY, vol. 314, pp. 193-199, ISSN:0300-8177

C. DONATI ; P. NINCHERI ; F. CENCETTI ; E. RAPIZZI ; M. FARNARARO ; P. BRUNI (2007). Tumor necrosis factor-α exerts promyogenic action in C2C12 myoblasts via sphingosine kinase/S1P2 signaling.. FEBS LETTERS, vol. 581, pp. 4384-4388, ISSN:0014-5793

RAPIZZI E; DONATI C; CENCETTI F; PINTON P; RIZZUTO R; P. BRUNI (2007). Sphingosine 1-phosphate receptors modulate intracellular Ca2+ homeostasis. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 353, pp. 268-274, ISSN:0006-291X

L.Becciolini; E.Meacci;C. Donati; F.Cencetti;E. Rapizzi; P.Bruni (2006). Sphingosine 1-phosphate inhibits cell migration in C2C12 myoblasts. BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1761, pp. 43-51, ISSN:0006-3002

Cipriani G;Rapizzi E;Vannacci A;Rizzuto R;Moroni F;Chiarugi A (2005). Nuclear poly(ADP-ribose) polymerase-1 rapidly triggers mitochondrial dysfunction.. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 280, pp. ---, ISSN:0021-9258 DOI

E. RAPIZZI; S. FOSSATI; F. MORONI; A. CHIARUGI (2004). INHIBITION OF POLY(ADP-RIBOSE) GLYCOHYDROLASE BY GALLOTANNIN SELECTIVELY UP-REGULATES EXPRESSION OF PRO-INFLAMMATORY GENES.. MOLECULAR PHARMACOLOGY, vol. 66, pp. 890-898, ISSN:0026-895X

P. Pinton;D. Ferrari;E. Rapizzi;F. D. Virgilio;T. Pozzan;R. Rizzuto (2002). A role for calcium in Bcl-2 action?. BIOCHIMIE, vol. 84, pp. 195-201, ISSN:0300-9084

E. Rapizzi;P. Pinton;G. Szabadkai;M. R. Wieckowski;G. Vandecasteele;G. Baird;R. A. Tuft;K. E. Fogarty;R. Rizzuto (2002). Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria.. THE JOURNAL OF CELL BIOLOGY, vol. 159, pp. 613-624, ISSN:0021-9525 DOI Accesso ONLINE all'editore

P. Pinton;D. Ferrari;E. Rapizzi;F. D. Virgilio;T. Pozzan;R. Rizzuto (2001). The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action.. EMBO JOURNAL, vol. 20, pp. 2690-2701, ISSN:0261-4189 DOI Accesso ONLINE all'editore

A. Chiesa;E. Rapizzi;V. Tosello;P. Pinton;M. d. Virgilio;K. E. Fogarty;R. Rizzuto (2001). Recombinant aequorin and green fluorescent protein as valuable tools in the study of cell signalling.. BIOCHEMICAL JOURNAL, vol. 355, pp. 1-12, ISSN:0264-6021

A. Ghirardello;A. Doria;S. Zampieri;R. Gerli;E. Rapizzi;P. F. Gambari (2000). Anti-ribosomal P protein antibodies detected by immunoblotting in patients with connective tissue diseases: their specificity for SLE and association with IgG anticardiolipin antibodies.. ANNALS OF THE RHEUMATIC DISEASES, vol. 59, pp. 975-981, ISSN:0003-4967

E. Rapizzi;A. Ruffatti;M. Tonello;A. Piccoli;A. Calligaro;P. Sfriso;S. Todesco (2000). Correction for age of anticardiolipin antibodies cut-off points.. JOURNAL OF CLINICAL LABORATORY ANALYSIS, vol. 14, pp. 87-90, ISSN:0887-8013

A. Ruffatti;C. Montecucco;D. Volante;T. D. Ross;T. Sartori;E. Rapizzi;S. Todesco (2000). Antiphospholipid antibody syndrome and polymyalgia rheumatica/giant cell arteritis.. RHEUMATOLOGY, vol. 39, pp. 565-567, ISSN:1462-0324

A. Ruffatti;B. D. Barba;T. D. Ross;F. Vettorato;E. Rapizzi;M. Tonello;V. Suma;P. Grella;P. F. Gambari (1998). Outcome of fifty-five newborns of antiphospholipid antibody-positive mothers treated with calcium heparin during pregnancy.. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, vol. 16, pp. 605-610, ISSN:0392-856X

M. L. Massimino;E. Rapizzi;M. Cantini;L. D. Libera;F. Mazzoleni;P. Arslan;U. Carraro (1997). ED2+ macrophages increase selectively myoblast proliferation in muscle cultures.. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 235, pp. 754-759, ISSN:0006-291X DOI Accesso ONLINE all'editore

M. Cantini;M. L. Massimino;E. Rapizzi;K. Rossini;C. Catani;L. D. Libera;U. Carraro (1995). Human satellite cell proliferation in vitro is regulated by autocrine secretion of IL-6 stimulated by a soluble factor(s) released by activated monocytes.. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 216, pp. 49-53, ISSN:0006-291X

Elena RAPIZZI

Curriculum

EDUCATION AND TRAINING

2014 - Florence - University of Florence - M.Sc.degree in Food Sciences (LM-61) 110/110 cum Laude
2000 - Padova - University of Padova - Ph.D. in Experimental Rheumatology(Cycle XII).
1996 - Padova - University of Padova - Qualification to the profession of biologist
1994 - Padova - University of Padova - M.Sc. degree in Biological Sciences.

WORK EXPERIENCE

2024-present Associate Professor. University of Florence, Department of Experimental and Clinical Medicine.

2021-2024 RTDb (Researcher senior track). University of Florence, Department of Experimental and Clinical Medicine.
2020-2021 RTDa. University of Florence, Department of Experimental and Clinical Medicine.
2016-2020 Post-doctoral fellowship. University of Florence, Department of Experimental and Clinical Medicine.
2011-2016 Post-doctoral fellowship. University of Florence, Department of Experimental and Clinical Biomedical Sciences.
2010-2011 Post-doctoral fellowship. University of Florence, Department of Clinical Physiopathology
2004-2008 Research fellowship. University of Florence, Department of Biochemistry.
2001-2003 Researcher enrolled in the University of Massachusetts Medical School, Department of Program in Molecular Medicine, Worcester, MA, USA
2001-2003 Telethon Long Term Post-doctoral Fellowship. University of Massachusetts Medical School, Department of Program in Molecular Medicine, Worcester, MA, USA
2000-2001 Post-doctoral fellowship. University of Ferrara, Department of Experimental and Diagnostic Medicine.
1999-2000 Fellowship. University of Ferrara, Department of Experimental and Diagnostic Medicine.
1996-1999 Ph.D. in Experimental Rheumatology. University of Padova, Department of Rheumatology.
1995-1996 Post-graduate Fellowship. University of Padova, Department of Experimental Biomedical Sciences.

CONTRIBUTION TO SCIENCE

Up to days, her scientific production counts 75 original manuscripts in international peer-reviewed journals, H-index =30 (source Scopus).

SCIENCENTIFIC INTEREST

She is particularly focused on the evaluation of the crosstalk between tumor microenvironment and tumor cells in order to better understand the molecular mechanisms underlying tumorigenesis, cancer progression and aggressiveness.