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Tommaso MELLO

Ruolo attuale:: Ricercatore Legge 240/10 a tempo determinato
SSD:: MEDS-26/D - Scienze tecniche mediche e chirurgiche avanzate
Afferenza organizzativa:: Dipartimento di Scienze Biomediche, Sperimentali e Cliniche 'Mario Serio'

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	0552758115
	tommaso.mello(AT)unifi.it

Tommaso MELLO

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Tesi di Dottorato

Matteoli, Gabriele; Alvente, Sara; Bastianini, Stefano; Berteotti, Chiara; Ciani, Elisabetta; Cinelli, Elenia; Lo Martire, Viviana; Medici, Giorgio; Mello, Tommaso; Miglioranza, Elena; Silvani, Alessandro; Mutolo, Donatella; Zoccoli, Giovanna (2024). Characterisation of sleep apneas and respiratory circuitry in mice lacking CDKL5. JOURNAL OF SLEEP RESEARCH, vol. .., pp. 1-13, ISSN:0962-1105 DOI Accesso ONLINE all'editore

Guida, A.; Simeone, I.; Papini, D.; Polvani, S.; Dragoni, G.; Ceni, E.; Picariello, L.; Galli, A.; Mello, T. (2024). Targeting RuvBL1 reduces mTOR-driven NASH-HCC progression in conditional PTEN-KO mice. DIGESTIVE AND LIVER DISEASE, vol. 56, pp. S96-S96, ISSN:1590-8658 DOI

Mello, T.; Guida, A.; Simeone, I.; Papini, D.; Vannucci, F.; Defazio, G.; Polvani, S.; Ceni, E.; Dragoni, G.; Innocenti, T.; Picariello, L.; Galli, A. (2024). RUVBL1 correlates with chaperones expression in HCC and its activity is required for HSF1-mediated stress response. DIGESTIVE AND LIVER DISEASE, vol. 56, pp. S97-S97, ISSN:1590-8658 DOI

Guida, A.; Simeone, I.; Papini, D.; Polvani, S.; Dragoni, G.; Ceni, E.; Picariello, L.; Galli, A.; Mello, T. (2024). OC.05.6: TARGETING RUVBL1 REDUCES MTOR-DRIVEN NASH-HCC DEVELOPMENT IN MICE. DIGESTIVE AND LIVER DISEASE, vol. 56, pp. S153-S153, ISSN:1590-8658 DOI

Serena Martinelli, Giulia Cantini, Arianna Pia Propato, Daniele Bani, Daniele Guasti, Patrizia Nardini, Laura Calosi, Tommaso Mello, Nicole Bechmann, Giovanna Danza, Fabio Villanelli, Letizia Canu, Mario Maggi, Massimo Mannelli, Elena Rapizzi, Michaela Luconi (2024). The 3D in vitro Adrenoid cell model recapitulates the complexity of the adrenal gland. SCIENTIFIC REPORTS, vol. 14, pp. ...-..., ISSN:2045-2322 DOI

Simeone, I.; Guida, A.; Polvani, S.; Ceni, E.; Bani, D.; Nardini, P.; Guasti, D.; Parri, M.; Santi, A.; Galli, A.; Mello, T. (2023). RuvBL1 ATPase activity is essential for mitochondrial integrity and function in HCC cells. DIGESTIVE AND LIVER DISEASE, vol. 55, pp. S58-S59, ISSN:1590-8658 DOI Accesso ONLINE all'editore

Guida, A.; Simeone, I.; Polvani, S.; Dragoni, G.; Ceni, E.; Picariello, L.; Galli, A.; Mello, T. (2023). RuvBL1 haploinsufficiency promotes hepatic lipid catabolism hampering NASH-HCC progression in mice. DIGESTIVE AND LIVER DISEASE, vol. 55, pp. S55-S56, ISSN:1590-8658 DOI Accesso ONLINE all'editore

Guida, A.; Simeone, I.; Papini, D.; Giovannini, A.; Polvani, S.; Dragoni, G.; Ceni, E.; Picariello, L.; Galli, A.; Mello, T. (2023). Targeting the AAA+ ATPase RuvBL1 reduces mTOR-driven NASH-HCC development in mice. DIGESTIVE AND LIVER DISEASE, vol. 55, pp. S225-S225, ISSN:1590-8658 DOI

Polvani, S.; Mello, T.; Ceni, E.; Guida, A.; Picariello, L.; Grappone, C.; Dragoni, G.; Lynch, E.N.; Innocenti, T.; Tarocchi, M.; Donati, C.; Bruni, P.; Milani, S.; Galli, A. (2023). T.03.4 SPHINGOSINES, COUP-TFII AND PANCREATIC CANCER. DIGESTIVE AND LIVER DISEASE, vol. 55, pp. S142-S146, ISSN:1590-8658 DOI

Giuseppe Defazio; Tommaso Mello; Andrea Galli (2023). The healthy control landscape of the human gut microbiota by using ITS1 DNA metabarcoding data. In: Bioinformatics Italian Society meeting 2023, Bioinformatics Italian Society, pp. 0-0. DOI

Russo, Sharon; Scotto di Carlo, Federica; Maurizi, Antonio; Fortunato, Giorgio; Teti, Anna; Licastro, Danilo; Settembre, Carmine; Mello, Tommaso; Gianfrancesco, Fernando (2023). A mutation in the ZNF687 gene that is responsible for the severe form of Paget's disease of bone causes severely altered bone remodeling and promotes hepatocellular carcinoma onset in a knock-in mouse model. BONE RESEARCH, vol. 11, pp. 0-0, ISSN:2095-4700 DOI Accesso ONLINE all'editore

Guida, A; Simeone, I; Polvani, S; Ceni, E; Picariello, L; Dragoni, G; Galli, A; Mello, T (2022). RuvBL1 haploinsufficiency improves mTOR-driven NASH-HCC development in mice. JOURNAL OF HEPATOLOGY, vol. 77, pp. 0-0, ISSN:0168-8278 DOI

Polvani, S; Pepe, S; Tempesti, S; Tarocchi, M; Marroncini, G; Bencini, L; Ceni, E; Mello, T; Picariello, L; Simeone, I; Grappone, C; Dragoni, G; Antonuzzo, L; Giommoni, E; Milani, S; Galli, A (2022). Isoforms of the orphan nuclear receptor COUP-TFII differentially modulate pancreatic cancer progression. INTERNATIONAL JOURNAL OF ONCOLOGY, vol. 60, pp. 0-16, ISSN:1019-6439 DOI Accesso ONLINE all'editore

Martinelli, Serena; Riverso, Maria; Mello, Tommaso; Amore, Francesca; Parri, Matteo; Simeone, Irene; Mannelli, Massimo; Maggi, Mario; Rapizzi, Elena (2022). SDHB and SDHD silenced pheochromocytoma spheroids respond differently to tumour microenvironment and their aggressiveness is inhibited by impairing stroma metabolism. MOLECULAR AND CELLULAR ENDOCRINOLOGY, vol. 547, pp. 111594-111604, ISSN:0303-7207 DOI

Martinelli, Serena; Amore, Francesca; Mello, Tommaso; Mannelli, Massimo; Maggi, Mario; Rapizzi, Elena (2022). Metformin Treatment Induces Different Response in Pheochromocytoma/Paraganglioma Tumour Cells and in Primary Fibroblasts. CANCERS, vol. 14, pp. 3471-3487, ISSN:2072-6694 DOI

Tommaso Mello, Irene Simeone, Alice Guida, Simone Polvani, Elisabetta Ceni, Daniele Bani, Patrizia Nardini, Daniele Guasti, Matteo Parri, Alice Santi, Andrea Galli, (2022). The AAA+ ATPase RuvBL1 localizes to mitochondria and supports HCC cell metabolism.. HEPATOLOGY, vol. 76 (Suppl 1), pp. 1255-1256, ISSN:1527-3350 DOI

E Maseroli, P Comeglio, C Corno, I Cellai, S Filippi, T Mello, A Galli, E Rapizzi, L Presenti, M C Truglia, F Lotti, E Facchiano, B Beltrame, M Lucchese, F Saad, G Rastrelli, M Maggi, L Vignozzi (2021). Testosterone treatment is associated with reduced adipose tissue dysfunction and nonalcoholic fatty liver disease in obese hypogonadal men. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, vol. 44, pp. 819-842, ISSN:1720-8386 DOI

Simeone, I; Guida, A; Materozzi, M; Polvani, S; Bani, D; Parri, M; Ceni, E; Galli, A; Mello, T (2021). A mitochondrial role of RuvBL1 ATPase in the regulation of HCC cell metabolism. DIGESTIVE AND LIVER DISEASE, vol. 53, pp. S36-S36, ISSN:1590-8658 DOI Accesso ONLINE all'editore

Biagiotti G.; Angeli A.; Giacomini A.; Toniolo G.; Landini L.; Salerno G.; Di Cesare Mannelli L.; Ghelardini C.; Mello T.; Mussi S.; Ravelli C.; Marelli M.; Cicchi S.; Menna E.; Ronca R.; Supuran C.T.; Richichi B. (2021). Glyco-Coated CdSe/ZnS Quantum Dots as Nanoprobes for Carbonic Anhydrase IX Imaging in Cancer Cells. ACS APPLIED NANO MATERIALS, vol. 4, pp. 14153-14160, ISSN:2574-0970 DOI Accesso ONLINE all'editore

Lucrezia Caselli, Marco Mendozza, Beatrice Muzzi, Alessandra Toti, Costanza Montis, Tommaso Mello, Lorenzo Di Cesare Mannelli, Carla Ghelardini,Claudio Sangregorio, Debora Berti (2021). Lipid Cubic Mesophases Combined with Superparamagnetic Iron Oxide Nanoparticles: A Hybrid Multifunctional Platform with Tunable Magnetic Properties for Nanomedical Applications. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, pp. 9268-9268, ISSN:1661-6596 DOI

Sardi C.; Martini E.; Mello T.; Camelliti S.; Sfondrini L.; Marcucci F.; Kallikourdis M.; Sommariva M.; Rumio C. (2021). Effect of acetylsalicylic acid on inflamed adipose tissue. Insulin resistance and hepatic steatosis in a mouse model of diet-induced obesity. LIFE SCIENCES, vol. 264, pp. 0-0, ISSN:0024-3205 DOI

P. Comeglio, E. Sarchielli, S. Filippi, I. Cellai, G. Guarnieri, A. Morelli, G. Rastrelli, E. Maseroli, S. Cipriani, T. Mello, A. Galli, B. J. Bruno, K. Kim, K. Vangara, K. Papangkorn, N. Chidambaram, M. V. Patel, M. Maggi, L. Vignozzi (2021). Treatment potential of LPCN 1144 on liver health and metabolic regulation in a non-genomic, high fat diet induced NASH rabbit model.. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, vol. 44, pp. 2175-2193, ISSN:0391-4097 DOI

Micheli L., Parisio C., Lucarini E., Vona A., Toti A., Pacini A., Mello T., Boccella S., Ricciardi F., Maione S., Graziani G., Lacal P.M., Failli P., Ghelardini C., Di Cesare Mannelli L. (2021). VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, pp. 1-19, ISSN:1756-9966 DOI

Flamini S.; Sergeev P.; Viana de Barros Z.; Mello T.; Biagioli M.; Paglialunga M.; Fiorucci C.; Prikazchikova T.; Pagano S.; Gagliardi A.; Riccardi C.; Zatsepin T.; Migliorati G.; Bereshchenko O.; Bruscoli S. (2021). Glucocorticoid-induced leucine zipper regulates liver fibrosis by suppressing CCL2-mediated leukocyte recruitment. CELL DEATH & DISEASE, vol. 12, pp. 0-0, ISSN:2041-4889 DOI Accesso ONLINE all'editore

Toti A.; Santi A.; Pardella E.; Nesi I.; Tomasini R.; Mello T.; Paoli P.; Caselli A.; Cirri P. (2021). Activated fibroblasts enhance cancer cell migration by microvesicles-mediated transfer of Galectin-1. JOURNAL OF CELL COMMUNICATION AND SIGNALING, vol. 15, pp. 405-419, ISSN:1873-9601 DOI Accesso ONLINE all'editore

Riley L.; Ammar O.; Mello T.; Giovannelli L.; Vignozzi L.; Muratori M. (2021). Novel methods to detect ROS in viable spermatozoa of native semen samples. REPRODUCTIVE TOXICOLOGY, vol. 106, pp. 51-60, ISSN:0890-6238 DOI

Lulli Matteo, Gragnani Laura, Mello Tommaso, Galli Andrea, Carloni Vinicio (2021). DNA Damage Response Protein CHK2 Regulates Metabolism in Liver Cancer. CANCER RESEARCH, pp. 2861-2873, ISSN:0008-5472

Roselli, Jenny; Innocenti, Tommaso; Lynch, Erica Nicola; Parisio, Laura; Macrì, Giuseppe; Milla, Monica; Mello, Tommaso; Galli, Andrea; Milani, Stefano; Tarocchi, Mirko (2020). Increased Risk of Liver Cirrhosis during Azathioprine Therapy for Crohn's Disease. CASE REPORTS IN GASTROINTESTINAL MEDICINE, vol. 2020, pp. 1-3, ISSN:2090-6528 DOI

Roselli, Jenny; Innocenti, Tommaso; Lynch, Erica Nicola; Parisio, Laura; Apolito, Pasquale; Mello, Tommaso; Macrì, Giuseppe; Milla, Monica; Biagini, Maria Rosa; Tarocchi, Mirko; Milani, Stefano; Galli, Andrea (2020). Stevens-Johnson Syndrome and Herpes Simplex Type 1 Infection during Adalimumab Therapy for Crohn's Disease. CASE REPORTS IN GASTROINTESTINAL MEDICINE, vol. 2020, pp. 1-3, ISSN:2090-6528 DOI

Innocenti T.; Dragoni G.; Roselli J.; Macri G.; Mello T.; Milani S.; Galli A. (2020). Non-small-bowel lesions identification by capsule endoscopy: A single centre retrospective study. CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY, pp. 1-7, ISSN:2210-7401 DOI Accesso ONLINE all'editore

Sarchielli E, Guarnieri G, Idrizaj E, Squecco R, Mello T, Comeglio P, Gallina P, Maggi M, Vannelli GB; Morelli A (2020). The G protein-coupled oestrogen receptor, GPER1, mediates direct anti-inflammatory effects of oestrogens in human cholinergic neurones from the nucleus basalis of Meynert. JOURNAL OF NEUROENDOCRINOLOGY, vol. 32, pp. 12837-12849, ISSN:0953-8194 DOI

Mello, Tommaso; Simeone, Irene; Galli, Andrea (2019). Mito-Nuclear Communication in Hepatocellular Carcinoma Metabolic Rewiring. CELLS, vol. 8, pp. 1-30, ISSN:2073-4409 DOI Accesso ONLINE all'editore

I. Simeone , M. Materozzi , E. Ceni , S. Polvani , M. Tarocchi , A. Galli , T. Mello (2019). A new regulator of mitochondrial OXPHOS in hepatocytes and HCC cell lines: the AAA plus ATPase RuvBL1. DIGESTIVE AND LIVER DISEASE. SUPPLEMENT, vol. Volume 51, Supplement 1, Page e39, pp. E39-E39, ISSN:1594-5804, ELSEVIER SCIENCE INC: DOI Accesso ONLINE all'editore

Ceni, Elisabetta; Mello, Tommaso; Polvani, Simone; Tarocchi, Mirko; Vasseur-Cognet, Mireille; Milani, Stefano; Galli, Andrea (2019). THU-449-Nuclear orphan receptor COUP-TF2 increases the resistence to anoikis and induces amoeboid movment and metastatic potential in hepatocellular carcinoma. JOURNAL OF HEPATOLOGY, vol. 70, pp. e356-E356, ISSN:0168-8278 DOI

Mello, Tommaso; Materozzi, Maria; Zanieri, Francesca; Simeone, Irene; Ceni, Elisabetta; Bereshchenko, Oxana; Polvani, Simone; Tarocchi, Mirko; Marroncini, Giada; Nerlov, Claus; Guasti, Daniele; Bani, Daniele; Pinzani, Massimo; Galli, Andrea (2019). Liver haploinsufficiency of RuvBL1 causes hepatic insulin resistance and enhances hepatocellular carcinoma progression. INTERNATIONAL JOURNAL OF CANCER, pp. 0-0, ISSN:0020-7136 DOI

E. Ceni , G. Dragoni , L. Ciambellotti , T. Mello , S. Polvani , I. Simeone , S. Milani , A. Galli (2019). NUCLEAR ORPHAN RECEPTOR COUP-TF2 INCREASED THE RESISTANCE TO ANIKOISIS AND THE METASTATIC POTENTIAL IN HEPATOCELLULAR CARCINOMA. DIGESTIVE AND LIVER DISEASE. SUPPLEMENT, vol. Volume 51, Supplement 2, pp. 0-0, ISSN:1594-5804 DOI Accesso ONLINE all'editore

E. Ceni, T. Mello, S. Polvani, M. Tarocchi, S. Milani, A. Galli (2019). Nuclear orphan receptor COUP-TF2 induces anoikis resistance, amoeboid migration and metastatic potential in hepatocellular carcinoma (HCC). DIGESTIVE AND LIVER DISEASE. SUPPLEMENT, vol. Volume 51, Supplement 1, pp. 0-0, ISSN:1594-5804 DOI

Branca J.J.V. , Maresca M. , Morucci G. , Mello T. , Becatti M. , Pazzagli L. , Colzi I. , Gonnelli C. , Carrino D. , Paternostro F. , Nicoletti C. , Ghelardini C. , Gulisano M. , Di Cesare Mannelli L. , Pacini A. (2019). Effects of Cadmium on ZO-1 Tight Junction Integrity of the Blood Brain Barrier.. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 20, pp. 1-19, ISSN:1422-0067 DOI

Mello, T; Simeone, I ; Materozzi, M ; Ceni, E; Polvani, S ; Tarocchi, M ; Galli, A (2019). A MITOCHONDRIAL ROLE FOR THE CANCER-RELATED AAA plus ATP-ASE RUVBL1. HEPATOLOGY, vol. 70, pp. 69A-70A, ISSN:0270-9139

Mello, T ] ; Materozzi, M ; Simeone, I ; Zanieri, F; Ceni, E ; Polvani, S ; Tarocchi, M ; Bereshchenko, O ; Galli, A (2018). Loss of Hepatic RuvBL1 Causes Chronic Liver Damage and Regeneration, Promoting Hepatocellular Carcinoma. HEPATOLOGY, vol. 68, pp. 1282A-1282 A, ISSN:0270-9139

Materozzi, M.; Zanieri, F.; Ceni, E.; Polvani, S.; Tarocchi, M.; Bereshchenko, O.; Galli, A.; Mello, T. (2018). Hepatocyte-specific deletion of RuvBL1 leads to chronic liver damage and regeneration, enhancing HCC development. JOURNAL OF HEPATOLOGY, vol. 68, pp. S46-S47, ISSN:0168-8278 DOI

Comeglio, Paolo; Cellai, Ilaria; Mello, Tommaso; Filippi, Sandra; Maneschi, Elena; Corcetto, Francesca; Corno, Chiara; Sarchielli, Erica; Morelli, Annamaria; Rapizzi, Elena; Bani, Daniele; Guasti, Daniele; Vannelli, Gabriella Barbara; Galli, Andrea; Adorini, Luciano; Maggi, Mario; Vignozzi, Linda (2018). INT-767 prevents NASH and promotes visceral fat brown adipogenesis and mitochondrial function. JOURNAL OF ENDOCRINOLOGY, vol. 238, pp. 107-127-127, ISSN:0022-0795 DOI Accesso ONLINE all'editore

Materozzi, M.; Zanieri, F.; Ceni, E.; Polvani, S.; Tarocchi, M.; Bereshchenko, O.; Galli, A.; Mello, T. (2018). Loss of hepatic RuvBL1 accelerates DEN-induced carcinogenesis due to chronic liver damage and regeneration. DIGESTIVE AND LIVER DISEASE, vol. 50, pp. 15-16, ISSN:1590-8658 DOI

Sanna, MARIA DOMENICA; Mello, Tommaso; Masini, Emanuela; Galeotti, Nicoletta (2018). Activation of ERK/CREB pathway in noradrenergic neurons contributes to hypernociceptive phenotype in H4 receptor knockout mice after nerve injury. NEUROPHARMACOLOGY, vol. 128, pp. 340-350, ISSN:0028-3908 DOI Accesso ONLINE all'editore

Resta, F.*; Micheli, L.; Laurino, A.; Spinelli, V.; Mello, T.; Sartiani, L.; Di Cesare Mannelli, L.; Cerbai, E.; Ghelardini, C.; Romanelli, M.N.; Mannaioni, G.; Masi, A. (2018). Selective HCN1 block as a strategy to control oxaliplatin-induced neuropathy. NEUROPHARMACOLOGY, vol. 131, pp. 403-413, ISSN:0028-3908 DOI Accesso ONLINE all'editore

Sarchielli, Erica; Comeglio, Paolo; Squecco, Roberta; Ballerini, Lara; Mello, Tommaso; Guarnieri, Giulia; Idrizaj, Eglantina; Mazzanti, Benedetta; Vignozzi, Linda; Gallina, Pasquale; Maggi, Mario; Vannelli, Gabriella; Morelli, Annamaria (2017). Tumor Necrosis Factor α Impairs Kisspeptin Signaling in Human Gonadotropin-Releasing Hormone Primary Neurons. THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 102, pp. 46-56, ISSN:1945-7197 DOI

Ceni, Elisabetta; Mello, Tommaso; Polvani, Simone; Vasseur Cognet, Mireille; Tarocchi, Mirko; Tempesti, Sara; Cavalieri, Duccio; Beltrame, Luca; Marroncini, Giada; Pinzani, Massimo; Milani, Stefano; Galli, Andrea (2017). The orphan nuclear receptor COUP-TFII coordinates hypoxia-independent proangiogenic responses in hepatic stellate cells. JOURNAL OF HEPATOLOGY, vol. 66, pp. 754-764, ISSN:0168-8278 DOI

Cellai, Filippo; Munnia, Armelle; Viti, Jessica; Doumett, Saer; Ravagli, Costanza; Ceni, Elisabetta; Mello, Tommaso; Polvani, Simone; Giese, Roger W.; Baldi, Giovanni; Galli, Andrea; Peluso, Marco E. M (2017). Magnetic hyperthermia and oxidative damage to dna of human hepatocarcinoma cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 18, pp. 939-953, ISSN:1661-6596 DOI Accesso ONLINE all'editore

Carloni, Vinicio; Lulli, Matteo; Madiai, Stefania; Mello, Tommaso; Hall, Andrew; Luong, Tu Vinh; Pinzani, Massimo; Rombouts, Krista; Galli, Andrea (2017). CHK2 overexpression and mislocalisation within mitotic structures enhances chromosomal instability and hepatocellular carcinoma progression. GUT, vol. 67, pp. 348-361, ISSN:0017-5749 DOI Accesso ONLINE all'editore

Lana, D.; Di Russo, J.; Mello, T.; Wenk, G.L.; Giovannini, M.G (2017). Rapamycin inhibits mTOR/p70S6K activation in CA3 region of the hippocampus of the rat and impairs long term memory. NEUROBIOLOGY OF LEARNING AND MEMORY, vol. 137, pp. 15-26, ISSN:1074-7427 DOI Accesso ONLINE all'editore

D'Antongiovanni, Vanessa; Martinelli, Serena; Richter, Susan; Canu, Letizia; Guasti, Daniele; Mello, Tommaso; Romagnoli, Paolo; Pacak, Karel; Eisenhofer, Graeme; Mannelli, Massimo; Rapizzi, Elena (2017). The microenvironment induces collective migration in SDHB-silenced mouse pheochromocytoma spheroids. ENDOCRINE-RELATED CANCER, vol. 24, pp. 555-564, ISSN:1351-0088 DOI

Lulli, M; Madiai, S; Mello, T; Rombouts, K; Galli, A; Carloni, V (2016). Defective Chromosome Segregation Causes DNA Damage and Structural Chromosome Abnormalities In Human Hepatocellular Carcinoma. THE AMERICAN JOURNAL OF PATHOLOGY, vol. 186, pp. 17-18, ISSN:0002-9440

Lulli, M.; Madiai, S.; Mello, T.; Tarocchi, M.; Rombouts, K.; Pinzani, M.; Galli, A.; Carloni, V. (2016). Mitotic Checkpoint CHK2 Upregulation is Linked to Chromosomal Instability in Human Hepatocellular Carcinoma. JOURNAL OF HEPATOLOGY, vol. 64, pp. 331-332, ISSN:0168-8278

Carloni, Vinicio; Lulli, Matteo; Madiai, Stefania; Mello, Tommaso; Hall, Andrew R.; Luong, Tu Vinh; Pinzani, Massimo; Rombouts, Krista; Galli, Andrea (2016). Defective Chromosome Segregation Causes DNA Damage and Chromosome Abnormalities In Human Hepatocellular Carcinoma. HEPATOLOGY, vol. 63, pp. 242-242, ISSN:0270-9139

Mello T.; Materozzi M.; Galli A. (2016). PPARs and mitochondrial metabolism: From NAFLD to HCC. PPAR RESEARCH, vol. 2016, pp. 1-18, ISSN:1687-4757 DOI Accesso ONLINE all'editore

Brancato, B; Munnia, A; Cellai, F; Ceni, Elisabetta; Mello, Tommaso; Bianchi, Simonetta; Catarzi, S; Risso, Gg; Galli, Andrea; Peluso, Me (2016). 8-Oxo-7,8-dihydro-2'-deoxyguanosine and other lesions along the coding strand of the exon 5 of the tumour suppressor gene P53 in a breast cancer case-control study.. DNA RESEARCH, vol. 23, pp. 395-402, ISSN:1340-2838 DOI

Sanna, M.D.; Peroni, D.; Mello, T.; Ghelardini, C.; Quattrone, A.; Galeotti, N (2016). Increase of neurofilament-H protein in sensory neurons in antiretroviral neuropathy: Evidence for a neuroprotective response mediated by the RNA-binding protein HuD. PHARMACOLOGICAL RESEARCH, vol. 111, pp. 23-33, ISSN:1043-6618 DOI Accesso ONLINE all'editore

Mello, T.; Zanieri, F.; Materozzi, M.; Bereshchenko, O.; Ceni, E.; Tarocchi, M.; Marroncini, G.; Polvani, S.; Tempesti, S.; Nerlov, C.; Milani, S.; Galli, A. (2016). Ruvbl1 regulates liver glucose metabolism via the Akt/mTOR pathway: Implications for hepatocellular carcinoma progression. DIGESTIVE AND LIVER DISEASE, vol. 48, pp. e8-e9, ISSN:1590-8658 DOI

Mello, T; Zanieri, F; Ceni, E; Galli, A (2016). Oxidative Stress in the Healthy and Wounded Hepatocyte: A Cellular Organelles Perspective. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, vol. 2016, pp. 1-15, ISSN:1942-0900 DOI

Maneschi, E; Cellai, I; Aversa, A; Mello, T; Filippi, S; Comeglio, P; Bani, D; Guasti, D; Sarchielli, E; Salvatore, G; Morelli, A; Mazzanti, B; Corcetto, F; Corno, C; Francomano, D; Galli, A; Vannelli, Gb; Lenzi, A; Mannucci, E; Maggi, M; Vignozzi, L. (2016). Tadalafil reduces visceral adipose tissue accumulation by promoting preadipocytes differentiation towards a metabolically healthy phenotype: Studies in rabbits.. MOLECULAR AND CELLULAR ENDOCRINOLOGY, vol. 424, pp. 50-70, ISSN:0303-7207 DOI

Enrico Luchinat; Alessandra Gianoncelli; Tommaso Mello; Andrea Galli; Lucia Banci (2015). Combining in-cell NMR and X-ray fluorescence microscopy to reveal the intracellular maturation states of human superoxide dismutase 1.. CHEMICAL COMMUNICATIONS, vol. 51, pp. 584-587, ISSN:1359-7345 DOI Accesso ONLINE all'editore

Irene, Fusco; Elisabetta, Coppi; Giovanna, Maraula; Daniele, Lana; Grazia, Giovannini Maria; Tommaso, Mello; Andrea, Galli; Felicita, Pedata; Anna Maria, Pugliese (2015). Role of ATP P2Y1 receptor in the rat dentate gyrus after a severe ischemic insult. In: XVI Meeting Italian Society for Neuroscience, Cagliari, October 8-11, 2015, d, pp. 201-201.

Pugliese, Am; Maraula, G; Lana, D; Fusco, I; Mello, T; Galli, A; Coppi, E; Pedata, F (2015). Role of P1 and P2 purinergic receptors in the dentate gyrus during in vitro ischemia. In: 6th Joint German-Italian Purine Club Meeting, International conference on purinergic signalling, Hamburg, July, 23-25 2015, d, pp. 49-49.

Ceni, E ; Tarocchi, M ; Polvani, S ; Malentacchi, C ; Marroncini, G ; Mello, T; Tempesti, S ; Galli, A (2015). THIENO-TRIAZOLODIAZEPINES BLOCK HEPATOCARCINOMA PROGRESSION BY HSP-DEPENDENT KINOMA INHIBITION. DIGESTIVE AND LIVER DISEASE. SUPPLEMENT, vol. Volume: 47, pp. E80-E80, ISSN:1594-5804

Sanna, Maria Domenica; Mello, Tommaso; Ghelardini, Carla; Galeotti, Nicoletta (2015). Inhibition of spinal ERK1/2-c-JUN signaling pathway counteracts the development of low doses morphine-induced hyperalgesia. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 764, pp. 271-277-277, ISSN:0014-2999 DOI

Polvani, S ; Tempesti, S; Tarocchi, M ; Marroncini, G ; Ceni, E ; Mello, T ; Farsi, M; Milani, S . (2015). A N-TRUNCATED ISOFORM OF THE ORPHAN NUCLEAR RECEPTOR COUP-TFII MODULATES PANCREATIC CANCER PROGRESSION. DIGESTIVE AND LIVER DISEASE. SUPPLEMENT, vol. 47, pp. E82-E82, ISSN:1594-5804

Tarocchi, M ; Marroncini, G ; Ceni, E ; Polvani, S ; Tempesti, S ; Mello, T ; Milani, S ; Galli, A . (2015). SIRT1 ACTIVATION PREVENTS APOPTOSIS AND SENESCENCE OF HEPATIC STELLATE CELL DURING LIVER INJURY. DIGESTIVE AND LIVER DISEASE. SUPPLEMENT, vol. 47, pp. E78-E78, ISSN:1594-5804

Ceni, E.; Tarocchi, M.; Polvani, S.; Marroncini, G.; Tempesti, S.; Mello, T.; Galli, A. (2015). P0244 : Thieno-triazolodiazepines block hepatocarcinoma progression by HSP-dependent kinoma inhibition. JOURNAL OF HEPATOLOGY, vol. 62, pp. S398-S398, ISSN:0168-8278 DOI

Fusco, I.; Coppi, E.; Maraula, G.; Lana, D.; Giovannini, M.G.; Mello, T.; Galli, A.; Pedata, F.; Pugliese, A.M. (2015). The selective antagonism of P2Y1 purinergic receptors prevents synaptic failure and affects cell proliferation induced by in vitro ischemia in rat dentate gyrus. In: 37° Congresso Nazionale della Società Italiana di Farmacologia, I nuovi orizzonti della ricerca farmacologica: tra etica e scienza, Napoli, 27-30 ottobre 2015, d, pp. 0-0.

Tarocchi, M ; Marroncini, G ; Polvani, S ; Tempesti, S ; Mello, T; Ceni, E ; Milani, S ; Peluso, M] ; Galli, A (2015). CHRONIC PARTICULATE MATTER EXPOSITION REPRESENTS A SECOND HIT IN THE PROGRESSION FROM STEATOSIS TO STEATOHEPATITIS. DIGESTIVE AND LIVER DISEASE. SUPPLEMENT, vol. 47, pp. E186-E186, ISSN:1594-5804

M.D. Sanna;A. Quattrone;T. Mello;C. Ghelardini;N. Galeotti (2014). The RNA-binding protein HuD promotes spinal GAP43 overexpression in antiretroviral-induced neuropathy. EXPERIMENTAL NEUROLOGY, vol. 261, pp. 343-353, ISSN:0014-4886 DOI

Gerace E.; Masi A.; Resta F.; Felici R.; Landucci E.; Mello T.; Pellegrini-Giampietro D.E.; Mannaioni G.; Moroni F. (2014). PARP-1 activation causes neuronal death in the hippocampal CA1 region by increasing the expression of Ca2+-permeable AMPA receptors. NEUROBIOLOGY OF DISEASE, vol. 70, pp. 43-52, ISSN:0969-9961 DOI

Pugliese, A.M.; Maraula, G.; Lana, D.; Coppi, E.; Mello, T.; Melani, A.; Galli, A.; Giovannini, M.G.; Pedata, F (2014). The selective antagonism of P2X(7) and P2Y(1) receptors prevents synaptic failure and affects cell proliferation induced by oxygen and glucose deprivation in rat dentate gyrus. PURINERGIC SIGNALLING, pp. 846-847, ISSN:1573-9538

Mello, T; Tarocchi, M; Perini, F; Buccoliero, F; Marroncini, G; Ceni, E; Polvani, S; Tempesti, S; Milani, S; Galli, A (2014). ANTAGONISTIC SIGNALLING BY PPARGAMMA AND ROSIGLITAZONE CONVERGE ON RUVBL1 REGULATION IN HCC CELLS. DIGESTIVE AND LIVER DISEASE, vol. 46, pp. 0-0, ISSN:1590-8658 DOI Accesso ONLINE all'editore

Maraula G;Lana D;Coppi E;Gentile F;Mello T;Melani A;Galli A;Giovannini MG;Pedata F;Pugliese AM (2014). The Selective Antagonism of P2X7 and P2Y1 Receptors Prevents Synaptic Failure and Affects Cell Proliferation Induced by Oxygen and Glucose Deprivation in Rat Dentate Gyrus.. PLOS ONE, vol. 9(12): e115273, pp. 1-23, ISSN:1932-6203 DOI

Ceni E; Mello T; Galli A. (2014). Pathogenesis of alcoholic liver disease: Role of oxidative metabolism.. WORLD JOURNAL OF GASTROENTEROLOGY, vol. 20, pp. 17756-17772, ISSN:1007-9327 DOI Accesso ONLINE all'editore

Mirko Tarocchi;Simone Polvani;Anna Julie Peired;Giada Marroncini;Massimo Calamante;Elisabetta Ceni;Daniela Rhodes;Tommaso Mello;Giuseppe Pieraccini;Alessandro Quattrone;Claudio Luchinat;Andrea Galli (2014). Telomerase activated thymidine analogue pro-drug is a new molecule targeting hepatocellular carcinoma. JOURNAL OF HEPATOLOGY, vol. 61, pp. 1064-1072, ISSN:0168-8278 DOI

Di Cesare Mannelli L.; Pacini A.; De Amici M.; Matera C:; Zanardelli M.; Mello T.; Dallanoce C.; Ghelardini C. (2014). Involvement of alpha7 nAChR subtype in rat oxaliplatin-induced neuropathy: effects of selective activation.. NEUROPHARMACOLOGY, vol. 79, pp. 37-48, ISSN:0028-3908 DOI

Maraula G.; Traini C.; Mello T.; Coppi E.; Galli A.; Pedata F.; Pugliese A.M. (2013). The selective antagonism of A2A adenosine receptors prevents synaptic failure induced by oxygen and glucose deprivation in rat dentate gyrus. In: 6th European Congress of Pharmacology, Granada, Spain, JUL 17-20, 2012, Zarzuelo, A; Jimenez, R, pp. 255-258.

Di Cesare Mannelli L.; Pacini A.; Bonaccini L.; Zanardelli M.; Mello T.; Ghelardini C. (2013). Morphological features and glial activation in oxaliplatin-dependent neuropathic pain.. THE JOURNAL OF PAIN, vol. 14, pp. 1585-1600, ISSN:1526-5900 DOI

Alessandra Aldinucci; Antonio Turco; Tiziana Biagioli; Francesca Maria Toma; Daniele Bani; Daniele Guasti; Cinzia Manuelli; Lisa Rizzetto; Duccio Cavalieri; Luca Massacesi; Tommaso Mello; Denis Scaini; Alberto Bianco; Laura Ballerini; Maurizio Prato; Clara Ballerini. (2013). Carbon nanotube scaffolds instruct human dendritic cells: modulating immune responses by contacts at the nanoscale.. NANO LETTERS, vol. 13, pp. 6098-6105, ISSN:1530-6984 DOI Accesso ONLINE all'editore

Carloni, V; Mazzocca, A; Mello, T; Galli3 and S Capaccioli, A (2013). Cell fusion promotes chemoresistance in metastatic colon carcinoma. ONCOGENE, vol. 32, pp. 2649-2660, ISSN:0950-9232

Maneschi, E; Vignozzi, L; Morelli, A; Mello, T; Filippi, S; Cellai, I; Comeglio, P; Sarchielli, E; Calcagno, A; Mazzanti, B; Vettor, R; Vannelli, Gb; Adorini, L; Maggi, M. (2013). FXR activation normalizes insulin sensitivity in visceral preadipocytes of a rabbit model of MetS.. JOURNAL OF ENDOCRINOLOGY, pp. 215-231, ISSN:0022-0795 DOI

Krista Rombouts; Vinicio Carloni; Tommaso Mello; Sara Omenetti; Sara Galastri; Stefania Madiai; Andrea Galli; Massimo Pinzani (2013). Myristoylated Alanine-Rich protein Kinase C Substrate (MARCKS) expression modulates the metastatic phenotype in human and murine colon carcinoma in vitro and in vivo. CANCER LETTERS, pp. 1-9, ISSN:0304-3835 DOI Accesso ONLINE all'editore

S. Polvani;M. Tarocchi;S. Tempesti;T. Mello;E. Ceni;F. Buccoliero;M. D'Amico;V. Boddi;M. Farsi;S. Nesi;G. Nesi;S. Milani;A. Galli (2013). COUP-TFII in pancreatic adenocarcinoma: Clinical implication for patient survival and tumor progression.. INTERNATIONAL JOURNAL OF CANCER, pp. 0-0, ISSN:0020-7136 DOI Accesso ONLINE all'editore

Manetti M.; Guiducci S.; Romano E.; Rosa I.; Ceccarelli C.; Mello T.; Milia A.F.; Conforti M.L.; Ibba-Manneschi L.; Matucci-Cerinic M. (2013). Differential expression of junctional adhesion molecules in different stages of systemic sclerosis. ARTHRITIS AND RHEUMATISM, vol. 65, pp. 247-257, ISSN:0004-3591 DOI

Rombouts K;Mello T;Liotta F;Galli A;Caligiuri A;Annunziato F;Pinzani M (2012). MARCKS Actin Binding Capacity Mediates Actin Filament Assembly During Mitosis In Human Hepatic Stellate Cells.. AMERICAN JOURNAL OF PHYSIOLOGY. CELL PHYSIOLOGY, vol. 303, pp. 357-367, ISSN:0363-6143 DOI

V. Carloni; A.Mazzocca; T. Mello; A. Galli; S. Capaccioli (2012). CELL FUSION PROMOTES CHEMORESISTANCE IN METASTATIC COLON CARCINOMA. ONCOGENE, vol. ......., pp. 1-12, ISSN:0950-9232 DOI

Maraula G; Traini C; Mello T; Pedata F; Pugliese AM (2012). Effects of oxygen and glucose deprivation on synaptic transmission and neural progenitor cells maturation in rat dentate gyrus: role of A 2A adenosine receptors. In: Sixth EPHAR Congress, Granada 2012, E-Journal of British Pharmacological Society, pp. P476-P476.

Maraula G;Traini C;Mello T;Coppi E;Galli A;Pedata F;Pugliese AM (2012). Effects of oxygen and glucose deprivation on synaptic transmission in rat dentate gyrus: Role of A(2A) adenosine receptors.. NEUROPHARMACOLOGY, vol. 67, pp. 511-520, ISSN:0028-3908 DOI

C. Nativi; O. Francesconi; G. Gabrielli; I. De Simone; B. Turchetti; T. Mello; L. Di Cesare Mannelli; C. Ghelardini; P. Buzzini; S. Roelens (2012). Aminopyrrolic synthetic receptors for monosaccharides: A class of carbohydrate-binding agents endowed with antibiotic activity versus pathogenic yeasts. CHEMISTRY, vol. 18, pp. 5064-5072, ISSN:1521-3765 DOI Accesso ONLINE all'editore

M. Tarocchi;S. Polvani;M. Calamante;T. Mello;F. Buccoliero;E. Ceni;C. Luchinat;I. Bertini;S. Milani;A. Galli (2012). Telomerase Activated Thymidine Analogue Prod-drug Prevents Growth and Induces Regression In Two In Vivo Models of Hepatocellular Carcinoma. JOURNAL OF HEPATOLOGY, vol. 56, pp. S128-S128, ISSN:0168-8278

Maneschi, E; Morelli, A; Filippi, S; Cellai, I; Comeglio, P; Mazzanti, B; Mello, T; Calcagno, A; Sarchielli, E; Vignozzi, L; Saad, F; Vettor, R; Vannelli, Gb; Maggi, M. (2012). Testosterone treatment improves metabolic syndrome-induced adipose tissue derangements.. JOURNAL OF ENDOCRINOLOGY, vol. 215, pp. 347-362, ISSN:0022-0795 DOI

M. Tarocchi;S. Vellei;F. Buccoliero;T. Mello;S. Polvani;E. Ceni;S. Milani;A. Galli (2012). Important Role of Sirt1 In the Survival and Activation of Hepatic Stellate Cells During Liver Injury. JOURNAL OF HEPATOLOGY, vol. 56, pp. S160-S160, ISSN:0168-8278

T. Mello;M. Tarocchi;F. Buccoliero;E. Ceni;S. Polvani;S. Milani;A. Galli (2012). Rosiglitazone reduces the in vitro and in vivo growth of HCC cell lines through a PPARgamma-independent inhibition of Ruvbl-1. HEPATOLOGY, vol. 56, pp. 617A-617A, ISSN:0270-9139

M. Tarocchi;S. Polvani;A. J. Peired;T. Mello;E. Ceni;F. Buccoliero;S. Deiana;C. Parrini;G. Pieraccini;C. Luchinat;I. Bertini;S. Milani;A. Galli (2012). Therapeutic effects of a telomerase activated pro-drug, acycloguanosyl 5 '-thymidyltriphosphate, in hepatocellular carcinoma. HEPATOLOGY, vol. 56, pp. 617A-617A, ISSN:0270-9139

L. Di Cesare Mannelli; L. Bonaccini; M. Zanardelli; T. Mello; A. Pacini; C. Ghelardini (2012). Involvement of alpha7 nAChR downregulation in rat oxaliplatin-induced neuropathy. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 117, pp. 57-57, ISSN:1122-6714

Gentilini A;Rombouts K;Galastri S;Caligiuri A;Mingarelli E;Mello T;Marra F;Mantero S;Roncalli M;Invernizzi P;Pinzani M (2012). Role of the stromal-derived factor-1 (SDF-1)-CXCR4 axis in the interaction between hepatic stellate cells and cholangiocarcinoma.. JOURNAL OF HEPATOLOGY, vol. 57, pp. 813-820, ISSN:0168-8278 DOI

C. Traini; F. Pedata; S. Cipriani; T. Mello; A. Galli; M.G. Giovannini; F. Cerbai; R. Volpini; G. Cristalli; A.M. Pugliese (2011). P2 receptor antagonists prevent synaptic failure and extracellular signal-regulated kinase 1/2 activation induced by oxygen and glucose deprivation in rat CA1 hippocampus in vitro.. EUROPEAN JOURNAL OF NEUROSCIENCE, vol. 33, pp. 2203-2215, ISSN:0953-816X DOI

Paterniti I;Melani A;Cipriani S;Corti F;Mello T;Mazzon E;Esposito E;Bramanti P;Cuzzocrea S;Pedata F (2011). Selective adenosine A2A receptor agonists and antagonists protect against spinal cord injury through peripheral and central effects.. JOURNAL OF NEUROINFLAMMATION, vol. 8, pp. 31-44, ISSN:1742-2094 DOI

M. Tarocchi;S. Polvani;T. Mello;E. Ceni;F. Buccoliero;L. Cioni;S. Milani;A. Galli (2011). Telomerase Activated Thymidine Analogue Pro-drug Is A New Molecule Targeting Hepatocellular Carcinoma. DIGESTIVE AND LIVER DISEASE, vol. 43, pp. S195-S195, ISSN:1590-8658

L. Di Cesare Mannelli; L. Bonaccini; T. Mello; M. Zanardelli; A. Pacini; C. Ghelardini (2011). Oxaliplain-induced neruopathic pain: glial involvement in spinal cord and brain.. In: 34° Congresso Associazione Italiana per lo Studio del Dolore, Riccione, 29-31 Maggio, pp. 0-0.

T. Mello;M. Tarocchi;F. Buccoliero;E. Ceni;S. Polvani;L. Cioni;S. Milani;A. Galli (2011). Pontin52 Is A Ppargamma Target Gene and Its Knockdown Reduces Hepatic Cancer In An Orthotopic-singenic Mouse Model. DIGESTIVE AND LIVER DISEASE, vol. 43, pp. S192-S192, ISSN:1590-8658

S. Matà; S. Ambrosini; T. Mello; F. Lolli; D. Minciacchi (2011). Anti-myelin associated glycoprotein antibodies recognize HNK-1 epitope on CNS.. JOURNAL OF NEUROIMMUNOLOGY, vol. 236, pp. 99-105, ISSN:0165-5728 DOI

L. Di Cesare Mannelli; L. Bonaccini; T. Mello; M. Zanardelli; A. Pacini; C. Ghelardini (2011). Glia activation along the nervous system during oxaliplatin-dependent neuropathic pain.. In: 8th IBRO World Congress of Neuroscience, Firenze, 14-18 Luglio, pp. 0-0.

Cartechini, Laura; Vagnini, Manuela; Palmieri, Melissa; Pitzurra, Lucia; Mello, Tommaso; Mazurek, Joy; Chiari, Giacomo (2010). Immunodetection of proteins in ancient paint media. ACCOUNTS OF CHEMICAL RESEARCH, vol. 43, pp. 867-876, ISSN:0001-4842 DOI

Mello T. (2010). Nuclear Receptors in the Regulation of Lipid Metabolism. CURRENT CARDIOVASCULAR RISK REPORTS, vol. 4, pp. 142-149, ISSN:1932-9520 DOI

Pugliese AM; Traini C; Cipriani S; Mello T; Galli A; Pedata F (2010). Antagonism of purinergic P2 receptors enhances neuronal survival and decreases ERK1/2 activation after oxygen-glucose deprivation in rat CA1 hippocampal slices. PURINERGIC SIGNALLING, vol. 6(1), pp. 55-56, ISSN:1573-9538 DOI

L. Bonaccini; T. Mello; C. Ghelardini; E. Sgambati; L. Di Cesare Mannelli; A. Pacini (2010). Oxaliplatin-induced neuropathy: glial activation in spinal cord and brain. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 115, pp. 23-23, ISSN:1122-6714

GALLI A; CENI E; MELLO T; POLVANI S; TAROCCHI M; BUCCOLIERO F; LISI F; CIONI L; OTTANELLI B; FORESTA V; MASTROBUONI G; MONETI G; PIERACCINI G; SURRENTI C; MILANI S (2010). Thiazolidinediones inhibit hepatocarcinogenesis in hepatitis B virus-transgenic mice by peroxisome proliferator-activated receptor gamma-independent regulation of nucleophosmin.. HEPATOLOGY, vol. 52, pp. 493-505, ISSN:0270-9139 DOI

A.M. Pugliese; C. Traini; S. Cipriani; M. Gianfriddo; T. Mello ; M.G. Giovannini; A. Galli; F. Pedata (2009). THE ADENOSINE A2A RECEPTOR ANTAGONIST ZM241385 ENHANCES NEURONAL SURVIVAL DURING OXYGEN-GLUCOSE DEPRIVATION IN RAT CA1 HIPPOCAMPUS. BRITISH JOURNAL OF PHARMACOLOGY, vol. 157, pp. 818-830, ISSN:0007-1188 DOI Accesso ONLINE all'editore

M. Tarocchi;E. Ceni;T. Mello;S. Polvani;F. Buccoliero;L. Cioni;B. Ottanelli;V. Foresta;S. Milani;A. Galli (2009). THIAZOLIDINEDIONES INHIBIT HEPATIC TUMOUR FORMATION IN HBV TRANSGENIC MICE BY A PPAR gamma-INDEPENDENT REGULATION OF NUCLEOPHOSMIN. HEPATOLOGY, vol. 50, pp. 858A-858A, ISSN:0270-9139

A. Lombardi; G. Cantini; T. Mello; M. Francalanci; S. Gelmini; L. Cosmi; V. Santarlasci; S. Degl'Innocenti; P. Luciani; C. Deledda; F. Annunziato;G. Forti; A. Galli; M. Serio; M. Luconi. (2009). Molecular mechanisms underlying the pro-inflammatory synergistic effect of tumor necrosis factor alpha and interferon gamma in human microvascular endothelium.. EUROPEAN JOURNAL OF CELL BIOLOGY, vol. 88, pp. 731-742, ISSN:0171-9335 DOI

T. Mello;S. Polvani;A. Galli (2009). Peroxisome proliferator-activated receptor and retinoic x receptor in alcoholic liver disease.. PPAR RESEARCH, vol. 2009, pp. 748174-748185, ISSN:1687-4757 DOI Accesso ONLINE all'editore

PUGLIESE A.M.; TRAINI C.; CIPRIANI S.; MELLO T.; CORRADETTI R.; GALLI A.; PEDATA; F (2009). Role of purinergic P2 receptors on neuronal survival and MAPK activation during oxygen-glucose deprivation in the rat CA1 hippocampus. In: 2009 Neuroscience Meeting Planner. Chicago, IL: Society for Neuroscience, 2009. Online, pp. Program No. 52.13/J1-Program No. 52.13/J1.

Pugliese A.M.; Traini C.; Gianfriddo M.; Mello T.; Galli A.; Pedata F. (2008). Blocking adenosine A2A receptors during oxigen-glucose deprivation delays anoxic depolarization and ameliorates neuronal survival in the rat CA1 hippocampus. PURINERGIC SIGNALLING, vol. 4(suppl.1), pp. S43-S43, ISSN:1573-9538 DOI

Mello, Tommaso; Nakatsuka, Alice; Fears, Sharry; Davis, Wilhelmina; Tsukamoto, Hidekazu; Bosron, William F; Sanghani, Sonal P (2008). Expression of carboxylesterase and lipase genes in rat liver cell-types. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 374, pp. 460-464, ISSN:0006-291X DOI

A. Lombardi; G. Cantini; E. Piscitelli; S. Gelmini; M. Francalanci; T. Mello; E. Ceni; G. Varano; G. Forti; M. Rotondi; A. Galli; M. Serio; M. Luconi (2008). A new mechanism involving ERK contributes to rosiglitazone inhibition of tumor necrosis factor-alpha and interferon-gamma inflammatory effects in human endothelial cells. ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY, vol. 28, pp. 718-724, ISSN:1079-5642 DOI

L.Guasti;O.Crociani;E.Redaelli;S.Pillozzi;S.Polvani;M.Masselli;T.Mello;A.Galli;A.Amedei;RS.Wymore;E.Wanke;A.Arcangeli (2008). Identification of a posttranslational mechanism for the regulation of hERG1 K+ channel expression and hERG1 current density in tumor cells.. MOLECULAR AND CELLULAR BIOLOGY, vol. 28, pp. 5043-5060, ISSN:0270-7306 DOI Accesso ONLINE all'editore

K. Rombouts; B. Lottini; A. Caligiuri; F. Liotta; T. Mello; V. Carloni; F. Marra; M. Pinzani (2008). MARCKS is a downstream effector in platelet-derived growth factor-induced cell motility in activated human hepatic stellate cells. EXPERIMENTAL CELL RESEARCH, vol. 314, pp. 1444-1454, ISSN:0014-4827

Tommaso Mello; Elisabetta Ceni; Calogero Surrenti; Andrea Galli (2008). Alcohol induced hepatic fibrosis: role of acetaldehyde.. MOLECULAR ASPECTS OF MEDICINE, vol. 29, pp. 17-21, ISSN:0098-2997

E. Ceni;S. Polvani;T. Mello;L. Cioni;F. Buccoliero;B. Ottanelli;F. Lisi;S. Milani;A. Galli (2007). Apolipoprotein AI regulatory protein 1 (ARP-1) coordinates profibrogenic responses during liver fibrosis. HEPATOLOGY, vol. 46, pp. 289A-289A, ISSN:0270-9139

M. PARRI; F. BURICCHI; E. GIANNONI; G. GRIMALDI; T. MELLO; G. RAUGEI; G. RAMPONI; P. CHIARUGI (2007). EphrinA1 activates a Src/focal adhesion kinase-mediated motility response leading to rho-dependent actino/myosin contractility. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 282(27), pp. 19619-19628, ISSN:0021-9258, American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824:

T. Mello;E. Ceni;S. Polvani;L. Cioni;F. Lisi;B. Ottanelli;F. Buccoliero;M. Tarocchi;S. Milani;A. Galli (2007). Oxidative stress induce collagen synthesis by c-Abl activation in human hepatic stellate cells. HEPATOLOGY, vol. 46, pp. 871A-871A, ISSN:0270-9139

M. Taddei ; M. Parri; T. Mello; A. Catalano; A. Levine; G. Raugei; G. Ramponi; P. Chiarugi (2007). Integrin-mediated cell adhesion and spreading engage different sources of reactive oxygen species.. ANTIOXIDANTS & REDOX SIGNALING, vol. 9, pp. 469-481, ISSN:1523-0864 DOI Accesso ONLINE all'editore

A. GALLI; MELLO T;CENI E;SURRENTI E;SURRENTI C (2006). The potential of antidiabetic thiazolidinediones for anticancer therapy.. EXPERT OPINION ON INVESTIGATIONAL DRUGS, vol. 15, pp. 1039-1049, ISSN:1354-3784

CENI E; CRABB DW; FOSCHI M; MELLO T; TAROCCHI M; PATUSSI V; MORALDI L; MORETTI R; MILANI S; C. SURRENTI; GALLI A (2006). Acetaldehyde inhibits PPARgamma via H2O2-mediated c-Abl activation in human hepatic stellate cells.. GASTROENTEROLOGY, vol. 131, pp. 1235-1252, ISSN:0016-5085

CENI E; MELLO T; TAROCCHI M; CRABB DW; CALDINI A; INVERNIZZI P; SURRENTI C; S. MILANI; GALLI A. (2005). Antidiabetic thiazolidinediones induce ductal differentiation but not apoptosis in pancreatic cancer cells.. WORLD JOURNAL OF GASTROENTEROLOGY, vol. 11, pp. 1122-1130, ISSN:1007-9327

A. Galli;E. Ceni;D. W. Crabb;M. Foschi;T. Mello;M. Tarocchi;C. Surrenti;S. Milani (2005). Acetaldehyde induced collagen synthesis by inhibition of PPARgamma trascriptional activity via hydrogen peroxide-mediated activation of c-Abl non-receptor tyrosine kinase in human hepatic stellate cells. HEPATOLOGY, vol. 42, pp. 609A-609A, ISSN:0270-9139

GALLI A.; CENI E.; CRABB D.W.; MELLO T.; SALZANO R.; GRAPPONE C.; MILANI S.; SURRENTI E.; SURRENTI C.; CASINI A. (2004). Antidiabetic thiazolidinediones inhibit invasiveness of pancreatic cancer cells via PPARgamma independent mechanisms. GUT, vol. 53, pp. 1688-1697, ISSN:0017-5749

E. Ceni;M. Tarocchi;T. Mello;S. Milani;A. Galli (2004). The orphan receptor COUP-TF II (Arp-1) is required for stellate cells activation and is involved in mitogenic responses in activated cells.. HEPATOLOGY, vol. 40, pp. 609A-609A, ISSN:0270-9139

E. Ceni;D. W. Crabb;T. Mello;E. Villa;F. Schepis;M. Tarocchi;M. R. Biagini;C. Corrado;A. Casini;S. Milani;C. Surrenti; A. Galli (2003). Antidiabetic thiazolidinediones inhibit hepatic tumor formation in HBV transgenic mouse model.. HEPATOLOGY, vol. 38, pp. 400A-400A, ISSN:0270-9139

A.GALLI; D.W.CRABB; E.CENI; R.SALZANO; T.MELLO; G.SVEGLIATI BARONI; F.RIDOLFI; L.TROZZI; C.SURRENTI; A.CASINI (2002). Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro. GASTROENTEROLOGY, vol. 12, pp. 1924-1940, ISSN:0016-5085

A. Galli;E. Ceni;R. Salzano;T. Mello;S. Milani;G. Svagliati-Baroni;C. Surrenti;A. Casini (2002). Reactive oxigen species (ROS) modulate mitogenic and motogenic responses in human hepatic stellate cells. GASTROENTEROLOGY, vol. 122, pp. A669-A669, ISSN:0016-5085

A. Galli;E. Ceni;T. Mello;R. Salzano;R. Manta;C. Surrenti;A. Casini (2002). Paracrine cross-talk between pancreatic cancer cells and periacinar stellate cells enhanced tumor progression. GASTROENTEROLOGY, vol. 122, pp. A488-A488, ISSN:0016-5085

A. Galli;E. Ceni;D. W. Crabb;T. Mello;R. Salzano;C. Surrenti;M. Foschi;A. Casini (2002). Acetaldehyde inhibits peroxisome proliferator-activated receptor gamma (PPARg) transcriptional activity in hepatic stellate cells. A MAPk/pkcdelta-dependent mechanism.. HEPATOLOGY, vol. 36, pp. 250A-250A, ISSN:0270-9139

A. Galli;G. Svegliati-Baroni;T. Mello;R. Salzano;E. Ceni;D. Crabb;A. Casini (2001). PPARgamma activation by antidiabetic thiazolidinediones reduces liver fibrosis and hepatic stellate cells activation in vivo. JOURNAL OF HEPATOLOGY, vol. 34, pp. 92-92, ISSN:0168-8278 DOI

Fiorucci S.; Antonelli E.; Morelli O.; Mencarelli A.; Casini A.; Mello T.; Palazzetti B.; Tallet D.; Del Soldato P.; Morelli A. (2001). NCX-1000, a NO-releasing derivative of ursodeoxycholic acid, selectively delivers NO to the liver and protects against development of portal hypertension. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 98, pp. 8897-8902, ISSN:0027-8424 DOI

A. Galli;D. W. Crabb;E. Ceni;R. Salzano;T. Mello;C. Surrenti;A. Casini (2001). Peroxisome proliferator-activated receptor gamma (PPARgamma) transcriptional activity is inhibited by acetaldehyde in human hepatic stellate cells (HSC). JOURNAL OF HEPATOLOGY, vol. 34, pp. 6-6, ISSN:0168-8278 DOI

A. Galli;D. W. Crabb;E. Ceni;R. Salzano;T. Mello;C. Surrenti;A. Casini (2000). Peroxisome proliferator-activated receptor Gamma (PPAR Gamma) modulates hepatic stellate cells activation.. GASTROENTEROLOGY, vol. 118, pp. A910-A910, ISSN:0016-5085

Tommaso MELLO

Curriculum

PERSONAL RESEARCH IDENTIFIERS
ResearchGate	https://www.researchgate.net/profile/Tommaso-Mello
Scopus Author ID	6602850128
ORCiD	https://orcid.org/0000-0002-6192-6902
WoS ReseacherID	AAO-7831-2021

APPOINTMENTS
May 2022-to date	Assistant Professor – Applied Medical Techniques (RTDb MED/50)
	University of Florence, Florence, Italy
	Biomedical research in oncology and fibrosis of the liver and the gut. Academic teaching.

March 2017-to date	Institutional Commitee for Laboratory Animale Care (OBPA) - Scientific Member
	University of Florence, Florence, Italy
	Topics: gastroenterology and confocal microscopy

2007-2022	Research Assistant (cat. D)
	University of Florence, Florence, Italy
	Biomedical research in oncology and fibrosis of the liver, gut and pancreas.

Nov.2004–Dec.2006	Research fellow
	Farmacogenomic Foundation “Fiorgen”, Sesto Fiorentino (Florence), Italy
	Biomedical research in liver and pancreatic oncology and fibrosis.

July 2004-Oct.2004	Research fellow
	University of Florence, Florence, Italy
	Biomedical research in liver fibrosis.

EDUCATION AND TRAINING
2009	Master 1^st level: Clinical Research Assistant (as auditor)
	Dept. of Clinical and Preclinical Pharmacology, University of Florence, Italy

June 2007-July 2007	XII Annual Course on 3D Microscopy of Living Cells and Image Processing Course
	University of British Columbia, Vancouver, Canada.

2006	Visiting scientist at École Polytechnique Fédérale de Lausanne
	Visitor in Boris Hinz Lab, to learn casting and imaging techniques for 2D silicon and 3D collagen gels.
	EPFL, Lausanne, Switzerland

2004	European Advanced Microscopy Network (EAMNET)
	Course: “Calcium Imaging for Cell Biologist
	University of Barcelona, Barcelona, Spain.

2002-2004	Doctorate course: Physiological and Nutritional Sciences
	University of Florence, Florence, Italy.
	Thesis title: “Molecular Mechanisms of Hepatic Fibrogenesis and Fibrolysis”

March 2003-July 2004	Ph.D. fellow
	Dept. of Biochemistry and Molecular Biology, Indiana University Purdue University School of Medicine, Indianapolis (IN, USA)
	Development of method for the isolation and purification of primary rat Hepatic Stellate Cells by FACS exploiting their Vitamin A autofluorescence.

HONORS, AWARDS AND QUALIFICATIONS
2022	Invited member of the international selection commitee - ARC Fondation
	Call: Recruiting International Leaders in Oncology

2020	Italian National Scientific Qualification (ASN)
	Associate Professor of Applied Medical Techniques (MED/50)

2018	Invited external Peer for the LEaDing Fellows Postdocs Programme (Marie Skłodowska-Curie COFUND Programme) - 2nd Call
	Delft University of Technology (The Netherlands) https://leadingfellows.eu/

2014	Italian National Scientific Qualification (ASN)
	Associate Professor of Applied Biology (BIO/13)

2003	Italian Society of Gastroenterology (SIGE)
	Project title: "Study of the PPAR-gamma polymorphism in patients affected by Chronic Liver Disease and fibrosis"

RESEARCH PROJECTS
2020-2023	Effetcs of MonoAcylGlycerold In Colorectal Cancer (MAGIC)
	Bando ricerca salute - Tuscany Region
	Team member

2018-2023	Metabolic reprogramming of hepatocellular carcinoma by oncogenic RuvBL1
	AIRC - FCRF
	Team member

2016-2020	Assaying tumor metabolic deregulation in live cells
	AIRC- ECRF Multi user equipment program
	Team member

2014-2016	Targeting oxidative DNA damage at genomic and sequence level in a breast cancer case-control study and in in vitro
	Regione Toscana - Istituto Toscano Tumori
	Team member

2011-2015	RuvBL1 in the pathogenesis of Hepatocellular Carcinoma
	Ministry of Health - GR1600315
	Principal Investigator

2014	Ruolo di Ruvbl1 nella patogenesi dell’HCC
	Ente CRF
	Principal Investigator

2006-2008	Ruolo dei recettori nucleari PPAR gamma nei meccanismi di cancerogenesi
	PRIN - MIUR - prot.2006063214
	Team member

2005-2007	Studio di nuovi meccanismi molecolari nel controllo della risposta fibrogenica
	PRIN - MIUR - prot.2005062350.
	Team member

2004-2006	Tuscany Region Study on Rosiglitazone (TRESOR)
	Tuscany Region
	Team member

EDITORIAL ACTIVITY
Editorial Board	MDPI - Cells
Guest Editor	MDPI - Int J Mol Sci (2020)
Editorial Board	Hindawi ISNR Hepatology (2013-2014)
Reviewer for	Clinical and Experimental Pharmacology and Physiology, Cell Biology and Toxicology, Fibrogenesis and Tissue Repair, International Journal of Hepatology, PPAR Research, Free Radical Biology & Medicine, Annual Research & Review in Biology, Cancer Management and Research, Disease Marker, DNA and Cell Biology, European Journal of Nutrition, Hepatobiliary & Pancreatic Disease International, Inflammation, New Journal of Science, Oncotargets and Therapy, Inflammation, International Journal of Molecular Sciences, Journal of Hepatocellular Carcinoma