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Chiara SASSOLI

Ruolo attuale:: Professore Associato
SSD:: BIOS-12/A - Anatomia umana
Afferenza organizzativa:: Dipartimento di Medicina Sperimentale e Clinica

Recapiti

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	chiara.sassoli(AT)unifi.it

Ulteriori Recapiti

csassoli(AT)unifi.it

Chiara SASSOLI

Curriculum

Nata ad Arezzo 11/06/1974

1999 Laurea in Scienze Biologiche-Università di Firenze - votazione 110 /110 e lode.

Dal 1999 al 2000 Tirocinio post-laurea, Dip. di Biologia Animale e Genetica e presso la Sezione di Anatomia del Dip. di Anatomia, Istologia e Medicina Legale dell'Università di Firenze

Ottobre 2000-Febbraio 2001 Guest Researcher , Blanchette Rockefeller Neurosciences Institute della Johns Hopkins University-Gaithersburg-MD-USA (Scientific Director Dr. Daniel L. Alkon)

2001 Abilitazione all'esercizio della professione di Biologo

Aprile-Giugno 2001 Incarico di collaborazione in un progetto di ricerca dal titolo: "Colture cellulari finalizzate alla valutazione dell'inibizione della crescita neoplastica da melatonina"(Assegnatario Fondi Prof. Bruno Neri, Dip. di Medicina Interna, Università di Firenze)

1/07/2001- 31/12/2001 Borsa di studio bandita dall'Ente Cassa Di Risparmio di Firenze per la

realizzazione di un progetto dal titolo "Ruolo degli antigeni neuronali Hu nella memoria: stabilizzazione dell'RNA ad opera di HuC ed HuD come possibile base molecolari dell'apprendimento”

1/01/2002-31/12/2004 Dottorato di Ricerca in Morfologia e Morfogenesi Umana- Università di Firenze.

6/05/2005 Conseguimento del titolo di Dottore di Ricerca presentando una dissertazione finale dal titolo: "Rimodellamento Citoscheletrico e sue implicazioni nella funzione e nello sviluppo di cellule muscolari scheletriche indifferenziata".

1/02/2005-31/01/2006 Borsa di studio (convenzione di ricerca tra il Dip. di Anatomia, Istologia e Med. Legale dell'Università di Firenze e la ditta Sigma Tau-Industrie Farmaceutiche Riunite S.p.A-) per la realizzazione della ricerca "Indagine istologica sull'effetto protettivo dell'acetil-L-Carnitina (ALCAR) in confronto al trattamento con Gabapentin su ratti affetti da neuropatie variamente indotte"

1/07/2006-30/06/2008 Assegno di Ricerca (SSD M-EDF/02 Metodi e Didattiche delle Attività Sportive) per la realizzazione della ricerca dal titolo: "Lesioni muscolari da sport: possibili strategie per la prevenzione del danno e il recupero funzionale.”

01/10/2008-31/10/2008 Incarico di collaborazione in un progetto di ricerca dal titolo "METEOSPORT" nell'ambito del progetto Laboratorio MeteoSalute promosso dal Centro Interdipartimentale di Bioclimatologia dell'Università di Firenze dall'Istituto di Biometeorologia Consiglio Nazionale delle Ricerche e dal Servizio Sanitario della Regione Toscana (I risultati sono stati pubblicati in un Report 2009 distribuito dal servizio Sanitario della Regione Toscana)

Dal 16/02/2009 Ricercatore (SSD M-EDF/02 Metodi e Didattiche delle Attività Sportive) Facoltà di Medicina e Chirurgia ora Dip. Medicina Sperimentale e Clinica- Università di Firenze. Conferma in ruolo nel 2012.

Dal 1/11/2017 Ricercatore BIO-16 (Settore concorsuale 05/H1 Anatomia Umana)

21-07-2017 Conseguimento Abilitazione Scientifica nazionale per le funzioni di Professore di II fascia per il settore 05/H1 (Anatomia Umana)

11-09-2019 Conseguimento Abilitazione Scientifica nazionale per le funzioni di Professore di I fascia per il settore 05/H1 (Anatomia Umana)

Dal 1 marzo 2020 Professoressa Associata di Anatomia Umana (BIO/16)

ATTIVITA’ DI RICERCA

Analisi morfo-funzionali dei meccanismi cellulari e molecolari alla base dei processi di riparazione e rigenerazione tissutale e fibrosi (focus muscolo scheletrico e cardiaco). Effetti di differenti molecule bioattive (sfingolipidi, relassina, plasma arricchito in piastrine) cellule mesenchimali stromali staminali, fotobiomodulazione sulla riparazione/rigenerazione dei tessuti
Età accademica 20 anni
Congedo per maternità:
Dal 12-8-2014 al 27-02-2015
Dal 13-12-2016 al 13-05-2017
Co-autrice di 49 pubblicazioni su riviste scientifiche internazionali [(IF medio= 4.5; H-index= 27; citazioni= 1523-Web of sciences), 1638 (Scopus)].
ORCID Id 0000-0002-1337-0938

Partecipazione a oltre 90 congressi internazionali e nazionali in molti dei quali in qualità di relatrice

PROGETTI /FINANZIAMENTI:

Responsabile scientifico

dal 01-01-2002 al 31-12-2003 "Progetto Giovani Ricercatori" istituito dal MURST (Bando 2001-Finanziamenti per iniziative di ricerca condotte da giovani ricercatori) finanziato dall'Università di Firenze nell'ambito del sistema relativo al cofinanziamento dei progetti di ricerca di rilevanza nazionale, per una ricerca dal titolo "Colture cellulari finalizzate alla valutazione dell'inibizione della crescita neoplastica da melatonina".

dal 01-01-2009 a oggi progetti di ricerca annuali finanziati dal Fondo per la ricerca di Ateneo ( MIUR ex quota 60%)

dal 15-05-2015 l 2017 Progetto finanziato dall'Ente Cassa di Risparmio di Firenze (Bando 2014-rif.2014/9106. Delibera approvazione pratica num 2014.0979) dal titolo "Rigenerazione muscolare post-danno: ruolo delle cellule mesenchimali stromali e dei telociti. Prospettivetraslazionali in medicina rigenerativa.”

Partecipante-Componente gruppo di Ricerca

2007 Componente Unità di Ricerca (1° anno 8 mesi-2° anno 2 mesi) in progetto PRIN (MUR Bando 2007-DM n. 1175 del 18 settembre 2007- prot. 2007PPMZRZ_001 -Coordinatore Scientifico e Responsabile dell'Unità di Ricerca Dr. Silvia Nistri) dal titolo L'ormone cardiovascolare relassina come possibile fattore di differenziamento di precursori cardiaci muscolari ed endoteliali in coltura in vitro" valutato positivamente, non ammesso al co-finanziamento per mancanze di risorse e finanziato in parte dall'Università di Firenze.

2009-2010 Partecipante Progetto PRIN-MIUR finanziato (Bando 2008- DM n. 1407 del 4 dicembre 2008- prot.20084XRSBS_003-Coordinatore Scientifico Prof. A. Orlacchio-Responsabile scientifico di Unità,. Prof. S. Zecchi-Orlandini) Titolo: "Ruolo dei biomateriali nel processo di migrazione e differenziamento di cellule staminali a vario grado di differenziamento: rilevanza nell'ambito di protocolli di medicina rigenerativa in campo cardiologico.”

2009-2010 Componente del gruppo di ricerca in un progetto finanziato dall'azienda General Project -Advanced Biomedical Thecnologies di Montespertoli Firenze per la ricerca dal titolo: "Basi biologiche per l'applicazione di nuove terapie laser odontoiatriche per la cura della malattia parodontale e delle complicanze della terapia implantare" (Responsabile scientifico Prof. Lucia Formigli)

2011 Componente del gruppo di ricerca nel progetto finanziato dall'Ente Cassa di Risparmio di Firenze (Bando 2011-rif.2011/1343 Responsabile scientifico Prof L. Formigli) Titolo "Cellule staminali e medicina rigenerativa: nuove prospettive terapeutiche per l'utilizzo delle cellule mesenchimali stromali del midollo osseo per la riparazione/rigenerazione del muscolo scheletrico".

2013-14 Componente gruppo di ricerca in Progetto finanziato dall'Ente Cassa di Risparmio di Firenze (Bando 2013 Responsabile scientifico Prof L. Formigli) Titolo "Cellule mesenchimali stromali del midollo osseo e biomateriali in medicina rigenerativa: influenza di diversi microambienti sul comportamento cellulare e prospettive terapeutiche.”

2013-14 Componente gruppo di ricerca in Progetto finanziato dall'Ente Cassa di Risparmio di Firenze (Bando 2013- Responsabile Scientifico Dott.ssa Roberta Squecco) Titolo: “Effetti dell’ormone relaxina sulla terapia cellulare per il recupero funzionale del tessuto cardiaco in seguito a danno ischemico: studio elettrofisiologico”.

2017-18 FFABR (Finanziamento annuale individuale delle attività base di ricerca)

RICONOSCIMENTI/PREMI SCIENTIFICI

Cells 2020 Best Paper Awards, Chellini et al. Cells, 2018, doi: 10.3390/cells7090142.
Cover page-Cells Tissues Organs, 206 (6) 283-380 (2018).
Best Poster presentation, Sassoli et al. (2012) “Morphofunctional interactions between mouse mesenchymal stromal/stem cells and myoblasts in co-culture: clues for skeletal muscle regeneration “In: 3rd Disputationes on Native and Induced Pluripotent Stem Cell Standardization. Florence, Italy, March 19-21, 2012.
Cover page- Journal of Cellular Physiology, vol 211-issue 2 (2007).

COMITATI EDITORIALI

Membro editorial board Current Molecular Medicine” ISSN: 1566-5240 Bentham Science – IF (2021): 2.61 Permanent Associate Editor Frontiers- Stem Cell Research (IF (2021) 6.081)
Guest Editor for Special Issue in Current Molecular Medicine-Thematic issue: “Fibrosis: from cellular and molecular targets to therapeutic strategies”.
Guest Editor for Special Issue in Cells (MDPI, IF (2021) 7.666) Thematic issue: “Regulatory Programs of Skeletal Muscle Repair and Regeneration”

ATTIVITA’ DI REVISIONE

Expert Opinion on Biological Therapy; Current Pharmaceutical Design; Lasers in Surgery & Medicine; International Journal of Molecular Sciences; International Journal of Stem Cells & Research; Current Molecular Medicine; Journal of Periodontal Research; Histology and Histopathology; Italian Journal of Anatomy and Embryology; Stem cells international; Cytotechnology; Cytotherapy; Life Sciences; Antioxidants; Frontiers in Pharmacology; International Journal of Radiation Biology; International Immunopharmacology; Tissue & Cell. Mini-Reviews in Medicinal Chemistry; Molecular Medicine Report

SOCIETA' SCIENTIFICHE

Società Italiana di Anatomia e Istologia (SIAI)
Interuniversity Institute of Myology (IIM)
Stem Cell Research Italy (SRCI)

ATTIVITA’ DIDATTICA

Dal 2004 docente titolare di Anatomia Umana per i corsi di Laurea, Univesità di Firenze, in Faramcia, Medicina e Chirurgia, Infermieristica, Logopedia, Chimica e Tecnologie Farmaceutiche, Scienze Motorie Sport e Salute, Fisioterapia (per non vedenti), Tecniche Erboristiche
Membro del collegio dei docenti di Dottorato in Scienze Biomediche, curriculum “Morfologia e Morfogenesi Umana”. Dal 2022 Supervisore della Dr. Martina Parigi (XVIII ciclo); co-supervisore del Dr. Francesco Palmieri (XVIII ciclo)

COORDINAMENTO ATTIVITA’ ACCADEMICHE

Dal 2015 Membro della commissione coordinamento corsi per il corso di laurea magistrale in Farmacia- Università di Firenze https://www.corsodilaureafarmacia.unifi.it/vp-108-organizzazione.html

ATTIVITA' ORGANIZZATIVA

2022 Organizzazione evento scientifico : “Seeing is believing...Cellular mechanisms of lung injury anddisease" Dr. Maurizio Chioccioli, Section of Pulmonary, Critical Care & Sleep Medicine YaleUniversity, School of Medicine, New Haven, CT, USA. September, 9, 2022. Dept. Experimental and Clinical Medicine, UNIFI, Florence, Italy

2012 Membro del comitato organizzativo del 66° Congresso nazionale della Società Italiana di Anatomia e Istologia (SIAI), Pistoia, Italia 20-22 settembre, 2012.

2011 Membro del comitato scientifico del corso di perfezionamento: "Fondamenti di microscopia confocale” Confocal
microscopy", Dip. di Anatomia e Istologia, Università di Firenze 2-4 marzo, 2011.

2005 e 2002 Membro del comitato scientifico del corso di perfezionamento in “Microscopie innovatie per le Biotecnologie”, Dip. di Anatomia e Istologia, Università di Firenze, 10-15 settembre 2005.

Chiara SASSOLI

Pubblicazioni

Legenda

Contributo su rivista |

Articolo su libro |

Libro |

Contributo in atti di convegno (proceeding) |

Brevetto |

Curatela | Altro

Altro |

Tesi di Dottorato

Parigi M., Palmieri F., Chellini F., Garella R., Tani A., Licini C., La Contana A., Longhin A., Zecchi-Orlandini S., Mattioli Belmonte Cima M., Squecco R., Sassoli C. (2024). Red photobiomodulation promotes skeletal myoblast differentiation and counteracts anti myogenic action of TGF-b1 in vitro: morpho-functional evidences. In: XII meeting Stem Cell Research Italy, Stem Cell Research Italy, pp. 0-0.

Garella R., Imbimbo E., Tani A., Chellini F., Palmieri F., Parigi M., Licini C., La Contana A., Giuliani A., Silvestri L., Sassoli C., Squecco R. (2024). Light sheet microscopy as a novel tool to observe satellite cell activation after eccentric contraction-induced damage at the muscle-tendon junction in a murine model. In: XII meeting Stem Cell Research Italy, Stem Cell Research Italy, pp. 0-0.

Sbrana, Francesca; Chellini, Flaminia; Tani, Alessia; Parigi, Martina; Garella, Rachele; Palmieri, Francesco; Zecchi-Orlandini, Sandra; Squecco, Roberta; Sassoli, Chiara (2024). Label-free three-dimensional imaging and quantitative analysis of living fibroblasts and myofibroblasts by holotomographic microscopy. MICROSCOPY RESEARCH AND TECHNIQUE, pp. 0-0, ISSN:1059-910X DOI Accesso ONLINE all'editore

Flaminia Chellini, Alessia Tani, Martina Parigi, Francesco Palmieri, Rachele Garella, Sandra Zecchi-Orlandini, Roberta Squecco, Chiara Sassoli (2023). Defining the role of HIF-1α and MMP-9 during skeletal myoblast differentiation. In: 76° Congresso Nazionale SIAI, Modena, 11-13 settembre 2023, Firenze University Press, pp. 198-198.

Martina Parigi, Francesco Palmieri, Flaminia Chellini, Alessia Tani, Rachele Garella, Sandra Zecchi-Orlandini, Daniele Martella, Roberta Squecco, Chiara Sassoli (2023). Morpho-functional evaluation of the effects of red photobiomodulation on skeletal myoblasts undergoing differentiation.. In: 50th European Muscle Conference, European Muscle Conference, pp. 90-90.

Martina Parigi, Francesco Palmieri, Flaminia Chellini , Alessia Tani, Caterina Licini, Rachele Garella, Daniele Martella, Gabriella Teti, Sandra Zecchi-Orlandini, Roberta Squecco, Mirella Falconi, Monica Mattioli Belmonte Cima, Chiara Sassoli (2023). Pro-diff erentiating eff ects of red photobiomodulation on skeletal myoblasts: morpho-functional evidences. In: 76° Congresso Nazionale SIAI, Firenze University Press, pp. 204-204.

Garella Rachele, Bernacchioni Caterina, Chellini Flaminia, Tani Alessia, Palmieri Francesco, Parigi Martina, Guasti Daniele, Cassioli Emanuele, Castellini Giovanni, Ricca Valdo, Bani Daniele, Sassoli Chiara, Donati Chiara, Squecco Roberta (2023). Adiponectin modulates smooth muscle cell morpho-functional properties in murine gastric fundus via sphingosine kinase 2 activation. LIFE, vol. 13, pp. 0-0, ISSN:2075-1729 DOI Accesso ONLINE all'editore

Chellini F.; Tani A.; Parigi M.; Palmieri F.; Garella R.; Zecchi-Orlandini S.; Squecco R.; Sassoli C. (2023). HIF-1α/MMP-9 Axis Is Required in the Early Phases of Skeletal Myoblast Differentiation under Normoxia Condition In Vitro. CELLS, vol. 12, pp. 0-0, ISSN:2073-4409 DOI

Garella, Rachele; Cassioli, Emanuele; Chellini, Flaminia; Tani, Alessia; Rossi, Eleonora; Idrizaj, Eglantina; Guasti, Daniele; Comeglio, Paolo; Palmieri, Francesco; Parigi, Martina; Vignozzi, Linda; Baccari, Maria Caterina; Ricca, Valdo; Sassoli, Chiara; Castellini, Giovanni; Squecco, Roberta (2023). Defining the Molecular Mechanisms of the Relaxant Action of Adiponectin on Murine Gastric Fundus Smooth Muscle: Potential Translational Perspectives on Eating Disorder Management. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 24, pp. 1082-1082, ISSN:1422-0067 DOI

Alice Cappitti, Francesco Palmieri, Rachele Garella, Alessia Tani, Flaminia Chellini, Martina Salzano De Luna, Camilla Parmeggiani, Roberta Squecco, Daniele Martella, Chiara Sassoli (2023). Development of accessible platforms to promote myofibroblast differentiation by playing on hydrogel scaffold composition. BIOMATERIALS ADVANCES, vol. 155, pp. 0-0, ISSN:2772-9508 DOI Accesso ONLINE all'editore

Sassoli, Chiara (2022). Fibrosis: from cellular and molecular targets to therapeutic strategies. EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES: BENTHAM SCIENCE PUBL LTD, pp. 193-195.

Flaminia Chellini, Alessia Tani, Rachele Garella, Daniele Martella, Alice Cappitti, Francesco Palmieri, Camilla Parmeggiani, Sandra Zecchi, Roberta Squecco, Chiara Sassoli (2022). An experimental model for fibroblasts to myofibroblasts transition on mechano-mimetic polyacrylamide hydrogels. In: 75° Congresso Nazionale SIAI, Firenze University Press, pp. 314-314.

Chiara Sassoli, Rachele Garella, Flaminia Chellini, Alessia Tani, Paola Pavan, Franco Bambi, Sandra Zecchi Orlandini, Roberta Squecco (2022). Platelet-rich plasma affects gap junctional features in myofibroblasts in vitro via vascular endothelial growth factor (VEGF)-A/VEGF receptor.. EXPERIMENTAL PHYSIOLOGY, vol. 107, pp. 106-121, ISSN:1469-445X DOI Accesso ONLINE all'editore

Sassoli, Chiara; Nistri, Silvia; Chellini, Flaminia; Bani, Daniele (2021). Human Recombinant Relaxin (Serelaxin) as Anti-fibrotic Agent: Pharmacology, Limitations and Actual Perspectives. CURRENT MOLECULAR MEDICINE, vol. 21, pp. 0-0, ISSN:1566-5240 DOI Accesso ONLINE all'editore

Squecco, Roberta; Tani, Alessia; Chellini, Flaminia; Garella, Rachele; Idrizaj, Eglantina; Rosa, Irene; Zecchi-Orlandini, Sandra; Manetti, Mirko; Sassoli, Chiara (2021). Bone Marrow-Mesenchymal Stromal Cell Secretome as Conditioned Medium Relieves Experimental Skeletal Muscle Damage Induced by Ex Vivo Eccentric Contraction. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, pp. 3645-3645, ISSN:1422-0067 DOI

Flaminia Chellini, Rachele Garella, Alessia Tani, Paola Pavan, Franco Bambi, Sandra Zecchi-Orlandini, Roberta Squecco, Chiara Sassoli (2021). Platelet rich plasma prevents voltage-dependent gap junction currents and Connexin 43 expression in TGFβ1- induced myofibroblasts in vitro through Vascular endothelial growth factor (VEGF)-A Mediated Signaling. In: 74° Congresso Nazionale SIAI, Firenze University Press, pp. 219-219.

Chellini F.; Tani A.; Zecchi-Orlandini S.; Giannelli M.; Sassoli C. (2020). In vitro evidences of different fibroblast morpho-functional responses to red, near-infrared and violet-blue photobiomodulation: Clues for addressingwound healing. APPLIED SCIENCES, vol. 10, pp. 1-21, ISSN:2076-3417 DOI Accesso ONLINE all'editore

Squecco, Roberta; Chellini, Flaminia; Idrizaj, Eglantina; Tani, Alessia; Garella, Rachele; Pancani, Sofia; Pavan, Paola; Bambi, Franco; Zecchi-Orlandini, Sandra; Sassoli, Chiara (2020). Platelet-Rich Plasma Modulates Gap Junction Functionality and Connexin 43 and 26 Expression During TGF-β1-Induced Fibroblast to Myofibroblast Transition: Clues for Counteracting Fibrosis. CELLS, vol. 9, pp. 1199-1229, ISSN:2073-4409 DOI

Manetti, Mirko; Tani, Alessia; Rosa, Irene; Chellini, Flaminia; Squecco, Roberta; Idrizaj, Eglantina; Zecchi-Orlandini, Sandra; Ibba-Manneschi, Lidia; Sassoli, Chiara (2019). Morphological evidence for telocytes as stromal cells supporting satellite cell activation in eccentric contraction-induced skeletal muscle injury. SCIENTIFIC REPORTS, vol. 9, pp. 14515-14515, ISSN:2045-2322 DOI

Sassoli, Chiara; Pierucci, Federica; Zecchi-Orlandini, Sandra; Meacci, Elisabetta (2019). Sphingosine 1-Phosphate (S1P)/ S1P Receptor Signaling and Mechanotransduction: Implications for Intrinsic Tissue Repair/Regeneration. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 20, pp. 5545-5565, ISSN:1422-0067 DOI Accesso ONLINE all'editore

Mirko Manetti, Alessia Tani, Irene Rosa, Flaminia Chellini, Roberta Squecco, Eglantina Idrizaj, Sandra Zecchi-Orlandini, Lidia Ibba-Manneschi, Chiara Sassoli (2019). Evidence supporting a morpho-functional interaction between telocytes and satellite cells in damaged skeletal muscle. In: Interuniversity Institute of Myology (IIM) International Meeting 2019, Assisi, 17-20 ottobre 2019, Interuniversity Institute of Myology (IIM), pp. p22-p22. Accesso ONLINE all'editore

Chellini, Flaminia; Tani, Alessia; Zecchi-Orlandini, Sandra; Sassoli, Chiara (2019). Influence of Platelet-Rich and Platelet-Poor Plasma on Endogenous Mechanisms of Skeletal Muscle Repair/Regeneration. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 20, pp. 683-689, ISSN:1422-0067 DOI Accesso ONLINE all'editore

Flaminia Chellini, Alessia Tani, Larissa Vallone, Daniele Nosi, Paola Pavan, Franco Bambi, Sandra Zecchi, Chiara Sassoli (2019). Platelet-rich plasma and bone marrow derived-mesenchymal stromal cells prevent TGF-β1 induced myofibroblast generation but are not synergistic when combined: morphological in vitro analysis. CELL TISSUES ORGAN, vol. 206(6), pp. 283-295, ISSN:1422-6421 DOI Accesso ONLINE all'editore

Chiara Sassoli; autori vari (2019). Anatomia Umana-Elementi con istituzioni di istologia. Peschiera Borromeo (MI): edi-ermes, ISBN:978-88-7051-541-1 Accesso ONLINE all'editore

Mirko Manetti, Alessia Tani, Irene Rosa, Flaminia Chellini, Roberta Squecco, Sandra Zecchi-Orlandini, Lidia Ibba-Manneschi, Chiara Sassoli (2019). Telocytes as “nursing” cells for satellite stem cells: morphological evidence from an experimental model of eccentric contraction-induced skeletal muscle injury. In: 73° Congresso Società Italiana di Anatomia e Istologia- SIAI, Napoli, 22-24 settembre 2019, Società Italiana di Anatomia e Istologia- SIAI, pp. 1-1.

Sassoli, Chiara; Vallone, Larissa; Tani, Alessia; Chellini, Flaminia; Nosi, Daniele; Zecchi-Orlandini, Sandra (2018). Combined use of bone marrow-derived mesenchymal stromal cells (BM-MSCs) and platelet rich plasma (PRP) stimulates proliferation and differentiation of myoblasts in vitro: new therapeutic perspectives for skeletal muscle repair/regeneration. CELL AND TISSUE RESEARCH, vol. 372, pp. 549-570, ISSN:0302-766X DOI Accesso ONLINE all'editore

Boccalini, Giulia; Sassoli, Chiara; Bani, Daniele; Nistri, Silvia (2018). Relaxin induces up-regulation of ADAM10 metalloprotease in RXFP1-expressing cells by PI3K/AKT signaling. MOLECULAR AND CELLULAR ENDOCRINOLOGY, vol. 472, pp. 80-86, ISSN:0303-7207 DOI

Chiara Sassoli, Federica Pierucci, Alessia Tani, Alessia Frati,Flaminia Chellini,Francesca Matteini, Ambra Vestri, Giulia Anderloni, Daniele Nosi, Sandra Zecchi, Elisabetta Meacci (2018). Sphingosine 1-Phosphate Receptor 1 Is Required for MMP-2 Function in Bone Marrow Mesenchymal Stromal Cells: Implications for Cytoskeleton Assembly and Proliferation. STEM CELLS INTERNATIONAL, vol. doi: 10.1155/2018/5034679., pp. 1-18, ISSN:1687-9678 DOI Accesso ONLINE all'editore

Tani, Alessia; Chellini, Flaminia; Giannelli, Marco; Nosi, Daniele; Zecchi-Orlandini, Sandra; Sassoli, Chiara (2018). Red (635 nm), Near-Infrared (808 nm) and Violet-Blue (405 nm) Photobiomodulation Potentiality on Human Osteoblasts and Mesenchymal Stromal Cells: A Morphological and Molecular In Vitro Study. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 19, pp. 1-23, ISSN:1422-0067 DOI Accesso ONLINE all'editore

Chellini, Flaminia; Tani, Alessia; Vallone, Larissa; Nosi, Daniele; Pavan, Paola; Bambi, Franco; Zecchi Orlandini, Sandra; Sassoli, Chiara (2018). Platelet-Rich Plasma Prevents In Vitro Transforming Growth Factor-β1-Induced Fibroblast to Myofibroblast Transition: Involvement of Vascular Endothelial Growth Factor (VEGF)-A/VEGF Receptor-1-Mediated Signaling. CELLS, vol. 7, pp. 0-0, ISSN:2073-4409 DOI Accesso ONLINE all'editore

Chiara Sassoli, Flaminia Chellini, Alessia Tani, Larissa Vallone, Franco Bambi, Paola Pavan , Sandra Zecchi (2018). Evidence supporting the preventive effect of Platelet- rich plasma (PRP) on TGFβ1-induced fibroblast/ myofibroblast transition via the involvement of VEGF receptor-1 (FLT-1) signaling. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 123, pp. 199-199, ISSN:1122-6714

Flaminia Chellini, Alessia Tani, Marco Giannelli, Daniele Nosi, Sandra Zecchi, Chiara Sassoli (2018). Photobiomodulation with 635 nm diode laser stimulates osteoblast differentiation via Akt signaling activation. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 123, pp. 63-63, ISSN:1122-6714

Giannelli, Marco; Bani, Daniele; Tani, Alessia; Materassi, Fabrizio; Chellini, Flaminia; Sassoli, Chiara (2017). Effects of an Erbium-Yttrium-Aluminum-Garnet (Er-YAG) Laser and an Ultrasonic Scaler on TiO2-Coated Titanium Surfaces Contaminated with Subgingival Plaque: an in Vitro Study to Assess Post-Treatment Biocompatibility to Osteogenic Cells. JOURNAL OF PERIODONTOLOGY, pp. 1-15, ISSN:0022-3492 DOI Accesso ONLINE all'editore

Chellini, Flaminia; Giannelli, Marco; Tani, Alessia; Ballerini, Lara; Vallone, Larissa; Nosi, Daniele; Zecchi-Orlandini, Sandra; Sassoli, Chiara (2017). Mesenchymal stromal cell and osteoblast responses to oxidized titanium surfaces pre-treated with λ = 808 nm GaAlAs diode laser or chlorhexidine: in vitro study. LASERS IN MEDICAL SCIENCE, vol. 32, pp. 1309-1320, ISSN:1435-604X DOI Accesso ONLINE all'editore

Vallone, Larissa; Sassoli, Chiara; Tani, Alessia; Chellini, Flaminia; Nosi, Daniele; Zecchi-Orlandini, Sandra (2017). Combined use in vitro of bone marrow-derived mesenchymal stromal cells (BM-MSCs) and Platelet Rich Plasma (PRP) as possible therapeutic tool for skeletal muscle repair/regeneration. In: ABCD congress (The Biennial Congress of the Italian Association of Cell Biology and Differentiation) 2017. Associazione di biologia cellulare e differenziamento., Bologna Savoia hotel Regency (Via del pilastro 2 40127), 21-23 September 2017., https://abcd2017.azuleon.org/, pp. 0-0. Accesso ONLINE all'editore

Silvia, Nistri; Chiara, Sassoli; Daniele, Bani (2017). Notch signaling in ischemic damage and fibrosis: evidence and clues from the heart. FRONTIERS IN PHARMACOLOGY, vol. 8, pp. 1-6, ISSN:1663-9812 DOI Accesso ONLINE all'editore

Zecchi-Orlandini, Sandra; Meacci, Elisabetta; Tani, Alessia; Chellini, Flaminia; Nosi, Daniele; Pierucci, Federica; Frati, Alessia; Matteini, Francesca; Vestri, Ambra; Sassoli, Chiara (2017). Modulation of MMP-2 function in bone marrow mesenchymal stromal cells requires sphingosine 1-phopsphate receptor 1 mediated signaling: implications for cytoskeletal assembly and proliferation. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 122, pp. 222-222, ISSN:2038-5129

Sassoli, Chiara; Chellini, Flaminia; Squecco, Roberta; Tani, Alessia; Idrizaj, Eglantina; Nosi, Daniele; Giannelli, Marco; Zecchi, Sandra (2016). Low intensity 635 nm diode laser irradiation inhibits fibroblast-myofibroblast transition reducing TRPC1 channel expression/activity: New perspectives for tissue fibrosis treatment. LASERS IN SURGERY AND MEDICINE, vol. 48, pp. 318-332, ISSN:0196-8092 DOI Accesso ONLINE all'editore

Pierucci, F; Sassoli, C; Tani, A; Frati, A; Bigi, A; Chellini, F; Matteini, F; Anderloni, G; Nosi, D; Mazzanti, B; Zecchi-Orlandini, S; Meacci, E (2016). Secreted sphingosine 1-phosphate exerts a novel autocrine action in bone marrow-derived mesenchymal stromal cell signalling. HUMAN GENE THERAPY, vol. 27, pp. 65-66, ISSN:1043-0342

Vallone, Larissa; Sassoli, Chiara; Tani, Alessia; Chellini, Flaminia; Nosi, Daniele; Mirabella, Carlo; Zecchi, Sandra (2016). Bone marrow-derived mesenchymal stromal cells and platelet rich plasma in skeletal muscle regeneration. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 121, pp. 82-82, ISSN:1122-6714 Accesso ONLINE all'editore

Squecco, Roberta; Sassoli, Chiara; Garella, Rachele; Chellini, Flaminia; Idrizaj, Eglantina; Nistri, Silvia; Formigli, Lucia; Bani, Daniele; Francini, Fabio (2015). Inhibitory effects of relaxin on cardiac fibroblast-to-myofibroblast transition: An electrophysiological study. EXPERIMENTAL PHYSIOLOGY, vol. 100, pp. 652-666, ISSN:0958-0670 DOI Accesso ONLINE all'editore

Chiara, Sassoli; Alessia, Tani; Flaminia, Chellini; Federica, Pierucci; Elena, Bruzzone; Larissa, Vallone; Daniele, Nosi; Francesca, Matteini; Elisabetta, Meacci; Sandra, Zecchi (2015). Regulation of MMP2 and MT1-MMP/MMP14 expression in mesenchymal stromal cells: a role for the bioactive lipid sphingosine 1-phosphate. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 120, pp. 133-133, ISSN:1122-6714 Accesso ONLINE all'editore

Boccalini G; Sassoli C; Formigli L; Bani D; Nistri S. (2015). Relaxin protects cardiac muscle cells from hypoxia/reoxygenation injury: involvement of the Notch-1 pathway. THE FASEB JOURNAL, vol. 29, pp. 239-249, ISSN:0892-6638 DOI Accesso ONLINE all'editore

Ornella, Fantappiè; Chiara, Sassoli; Alessia, Tani; Daniele, Nosi; Marchetti, S; Lucia, Formigli; Roberto, Mazzanti (2015). Mitochondria of a human multidrug-resistant hepatocellular carcinoma cell line constitutively express inducible nitric oxide synthase in the inner membrane. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. 19, pp. 1410-1417, ISSN:1582-4934 DOI Accesso ONLINE all'editore

Vallone, Larissa; Tani, Alessia; Chellini, Flaminia; Sassoli, Chiara; Nosi, Daniele; Mirabella, Carlo; D’Asta, Federica; Zecchi, Sandra (2015). Platelet rich plasma (PRP): new perspectives in skeletal muscle re generation after damage. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 120, pp. 157-157, ISSN:1122-6714 Accesso ONLINE all'editore

Russo Paola R.; Fundarò Salvatore P.; Sassoli Chiara (2014). Lifting invisibile-Manuale di pratica clinica. OEO Officina Editoriale Oltrarno Firenze, ISBN:9788897986089 Accesso ONLINE all'editore

Flaminia Chellini; Chiara Sassoli; Alessia Tani; Daniele Nosi; Roberta Squecco; Marco Giannelli; Sandra Zecchi Orlandini (2014). Diode laser stimulation prevents fibroblast-myofibroblast transition reducing TRPC1 expression/activity: new perspectives for tissue fibrosis treatment. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 119 suppl 1, pp. 44-44, ISSN:1122-6714 Accesso ONLINE all'editore

Alessia Tani; Chiara Sassoli ; Alessia Frati; Flaminia Chellini; Elisabetta Meacci; Sandra Zecchi (2014). Mesenchymal stromal cells exert a stimulatory effect on skeletal myoblast proliferation through the release of sphingosine 1-phosphate (S1P).. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 119 suppl 1, pp. 190-190, ISSN:1122-6714 Accesso ONLINE all'editore

Chiara, Sassoli; Daniele, Nosi; Alessia, Tani; Flaminia, Chellini; Benedetta, Mazzanti; Franco, Quercioli; Sandra, Zecchi; Lucia, Formigli (2014). Defining the role of mesenchymal stromal cells on the regulation of matrix metalloproteinases in skeletal muscle cells.. EXPERIMENTAL CELL RESEARCH, vol. 323(2), pp. 297-313, ISSN:0014-4827 DOI Accesso ONLINE all'editore

Sassoli, C.; Frati, A.; Tani, A.; Anderloni, G.; Pierucci, F.; Matteini, F.; Chellini, F.; Zecchi, S.; Formigli, L.; Meacci, E. . (2014). Mesenchymal Stromal Cell Secreted Sphingosine 1-Phosphate (S1P) Exerts a Stimulatory Effect on Skeletal Myoblast Proliferation.. PLOS ONE, pp. 1-10, ISSN:1932-6203 DOI Accesso ONLINE all'editore

Frank H. Netter; Anna Maria Billi; Lucio Cocco; Raffaele De Caro; Eugenio Gaudio; Lucia Manzoli; Stefania Montagnani; Rita Rezzani; Sandra Zecchi; Giovanni Zummo; Marco Vitale; Chiara Sassoli (2014). Netter Atlante di Anatomia Umana-Quinta edizione. Accesso ONLINE all'editore

Sandra Zecchi-Orlandini; Chiara Sassoli; Flaminia Chellini; Alessandro Pini; Silvia Nistri; Daniele Bani; Lucia Formigli (2013). Relaxin antagonizes the effects of TGF-β/Smad3 axis on cardiac fibroblast-myofibroblast transition through the upregulation of Notch-1 signalling. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 118,n.2 (Supplement), pp. 199-199, ISSN:1122-6714

Chiara Sassoli; Daniele Nosi; Alessia Tani; Flaminia Chellini; Benedetta Mazzanti; Franco Quercioli; Lucia Formigli (2013). Mesenchymal stromal cells and their paracrine fac-tors regulate MMP-2 and MMP-9/ TIMP-2 balance in skeletal myoblasts and fibroblasts: new insights into the potential role of MSC-cell therapy in mus-cle regenerative medicine. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 118,n.2 (Supplement), pp. 166-166, ISSN:1122-6714

Chiara Sassoli; Sandra Zecchi-Orlandini; Daniele Bani; Lucia Formigli (2013). Cardiac Progenitor Cells as Target of Cell and Growth Factor-Based Therapies for Myocardial Regeneration. JOURNAL OF STEM CELL RESEARCH AND THERAPY, pp. 1-9, ISSN:2157-7633 DOI Accesso ONLINE all'editore

Chiara Sassoli; Flaminia Chellini;Alessandro Pini; Alessia Tani;Silvia Nistri;Daniele Nosi;Sandra Zecchi;Daniele Bani;Lucia Formigli (2013). Relaxin prevents cardiac fibroblast-myofibroblast transition via Notch-1-mediated Inhibition of TGF-β/Smad3 signaling. PLOS ONE, vol. 8 issue 5, pp. 0-0, ISSN:1932-6203 DOI Accesso ONLINE all'editore

Lucia Formigli; Silvia Nistri; Chiara Sassoli; Daniele Bani (2013). Relaxin, cardiac stem cells and heart regeneration. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, pp. 77-79, ISSN:1122-6714 Accesso ONLINE all'editore

Sassoli, C.; Zecchi, S.; Formigli, L. (2012). Trophic Actions of Bone Marrow-Derived Mesenchymal Stromal Cells for Muscle Repair/Regeneration. CELLS, vol. 1(4), pp. 832-850, ISSN:2073-4409 DOI Accesso ONLINE all'editore

M. Giannelli;A. Pini;C. Sassoli;F. Chellini;L. Lorenzini ; R. Squecco; B. Mazzanti; D. Bani;L. Formigli (2012). Effect of low level laser irradiation on bone marrow mesenchymal stromal cells for bone tissue regeneration.. CLINICAL ORAL IMPLANTS RESEARCH, vol. 23 (Supplement 7), pp. 232-233, ISSN:1600-0501

L.Formigli; C.Sassoli (2012). Facial aging: tecniche mediche, chirurgiche ed odontostomatologiche per il terzo medio ed inferiore del volto di Alessio Redaelli, Frederic Braccini. Firenze: Officina Editoriale Oltrarno (OEO), ISBN:8890503386

A. Pini; C. Sassoli; F. Chellini; R. Squecco; B. Mazzanti; M. Giannelli; L. Formigli. (2012). Low Level Laser Irradiation (LLLI) stimulated bone marrow mesenchymal stromal cell proliferation in vitro: an useful tool for enhancing cell-based tissue repair/ regeneration. In: Development, Function and Repair of the Muscle Cell- Society for Muscle Biology-Frontiers in Myogenesis, Kimmel Center-New York University, NY, USA, June 4-8, 2012, pp. 56-56.

C. Sassoli ; F. Chellini; A. Pini; B. Mazzanti; D. Nosi; S. Zecchi; L. Formigli. (2012). Morphofunctional interactions between mouse mesenchymal stromal/stem cells and myoblasts in co-culture: clues for skeletal muscle regeneration.. In: 3rd Disputationes on Native and Induced Pluripotent Stem Cell Standardization, Florence, Italy, March 19–21, 2012, River Publishers, pp. 1-1, ISBN:9788792329257

A. Pini; F. Chellini; C. Sassoli; B. Mazzanti; D. Bani;L. Formigli (2012). Laser biostimulation of mouse bone marrow mesenchymal stromal cells: effects on cell proliferation and Notch-1 expression.. In: 3rd Disputationes on Native and Induced Pluripotent Stem Cell Standardization., Florence, Italy, March 19–21, 2012, River Publishers, pp. 1-1, ISBN:9788792329257

F. Francini; C. Sassoli;D. Nosi;F. Chellini;M. Giannelli;R. Squecco (2012). Effects of diode laser 635 nm stimulation on K+ and Ca2+ channel currents in mesenchymal stem/stromal cells isolated from mouse bone marrow. In: 3rd Disputationes on Native and Induced Pluripotent Stem Cell Standardization, Florence, Italy, March 19–21, 2012, River Publishers, pp. 1-1, ISBN:9788792329257

Giannelli, M.; Chellini, F.; Sassoli, C.; Francini, F.; Pini, A.; Squecco, R.; Nosi, D.; Bani, D.; Zecchi, S.; Formigli, L. . (2012). Photoactivation of bone marrow mesenchymal stromal cells with diode laser: Effects and mechanisms of action.. JOURNAL OF CELLULAR PHYSIOLOGY, vol. 228, pp. 172-181, ISSN:0021-9541 DOI

S.Nistri; A.Pini; C.Sassoli; R.Squecco; F.Francini; L.Formigli; D.Bani (2012). Relaxin promotes growth and maturation of mouse neonatal cardiomyocytes in vitro. clues for cardiac regeneration.. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. May 6. doi: 10.1111/j.1582-4934.2011.01328.x, pp. 1-10, ISSN:1582-1838

C. Sassoli; A. Pini ;F. Chellini ; B. Mazzanti; S. Nistri; D. Nosi; R. Saccardi; F. Quercioli;S. Zecchi;F. Formigli (2012). Bone marrow mesenchymal stromal cells stimulate skeletal myoblast proliferation through the paracrine release of VEGF.. PLOS ONE, vol. ..., pp. 37512-37525, ISSN:1932-6203 DOI

S. Pratesi; F. Paternostro; A. Tani; C. Sassoli; A.C. Cappellini (2012). Body mass index correlates with waist circumference in school aged Italian children. DIABETES RESEARCH AND CLINICAL PRACTICE, vol. ..., pp. 7-9, ISSN:0168-8227 DOI Accesso ONLINE all'editore

C.Sassoli ;F. Chellini ; A. Pini; A.Tani;L. Formigli (2012). Fibroblast-myofibroblast transition and extracellular matrix remodeling in vitro: implication for Notch-1 pathway in muscle tissue repair/regeneration. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 117, N.1 (Supplement), pp. 172-172, ISSN:1122-6714

C. Sassoli; F. Chellini; A. Pini; B. Mazzanti; S. Nistri; S. Zecchi; L. Formigli. (2012). Bone marrow mesenchymal stromal cells stimulate skeletal myoblast proliferation in vitro: therapeutic potential for muscle repair/regeneration.. In: Development, Function and Repair of the Muscle Cell- Society for Muscle Biology-Frontiers in Myogenesis, Kimmel Center-New York University, NY, USA, June 4-8, 2012, pp. 40-40.

L. Formigli; S. Nistri; C. Sassoli; D. Bani (2012). Relaxin, stem cells and cardiac regeneration. In: 6th International Conference on Relaxin and Related Peptides, Florence, Chiostro del Maglio, 8-12 October 2012, 6th International Conference on Relaxin and Related Peptides, pp. 85-85. Accesso ONLINE all'editore

F. Chellini; A.Tani; C. Sassoli; D. Nosi; B. Mazzanti; S. Zecchi; L. Formigli (2012). Metalloprotease activity in skeletal muscle cells is potentiated by paracrine factors released by mesenchymal stromal cells. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 117, N.1 (Supplement), pp. 38-38, ISSN:1122-6714

C. Sassoli; A. Pini; B. Mazzanti; S. Nistri; F. Quercioli; S. Zecchi-Orlandini; D. Bani; L. Formigli. (2011). Cardiac progenitor mesenchymal stem cell interaction: new perspectives for myocardial repair/regeneration. In: 40 th Keystone Symposia Meeting. Mechanisms of cardiac growth, death and regeneration., Keystone Resort, Keystone Colorado, USA, February 22-27, 2011, pp. P308, pg 95-P308, pg 95.

C. Sassoli; F. Chellini; B. Mazzanti; S. Nistri; A. Pini; S. Zecchi; L. Formigli. (2011). Mesenchymal stromal cells stimulate C2C12 myoblast cell proliferation: potential relevance in skeletal muscle regeneration.. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 116, pp. 166-166, ISSN:1122-6714

A. Pini; S. Nistri; C. Sassoli; R. Squecco; F. Francini; L. Formigli; D. Bani. (2011). Relaxin promotes proliferation and maturation of mouse neonatal cardiomyocites in vitro. Possible implications for cardiac regenerative medicine.. In: 40 th Keystone Symposia Meeting. Mechanisms of cardiac growth, death and regeneration., Keystone Resort, Keystone Colorado, USA., February 22-27, 2011, 40 th Keystone Symposia Meeting, pp. 92-92.

C.Sassoli; A. Pini; B. Mazzanti; F. Quercioli; S. Nistri; R. Saccardi; S.Zecchi-Orlandini; D. Bani; L. Formigli. (2011). Mesenchymal stromal cells affect cardiomyocyte growth through juxtacrine Notch-1/Jagged-1 signaling and paracrine mechanisms: clues for cardiac regeneration.. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, vol. 51, pp. 399-408, ISSN:0022-2828 DOI

S. Pratesi; F. Paternostro; A.Tani; C. Sassoli; A.C. Cappellini (2011). Waist circumference correlates with Body Mass Index (B.M.I.) in school-aged children.. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. Vol. n° 116, n° 1 suppl. -Atti del 65° Congresso Nazionale della Società Italiana di Anatomia e Istologia, pp. 150-150, ISSN:1122-6714

C. Sassoli; L. Formigli; F. Bini; A. Tani; R. Squecco; C. Battistini; S. Zecchi-Orlandini; F. Francini; E. Meacci. (2011). Effects of S1P on skeletal muscle repair/regeneration during eccentric contraction.. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. 15, pp. 2498-2511, ISSN:1582-1838 DOI

L. Formigli; C. Sassoli; A. Tani; R. Squecco; F. Francini; E. Meacci; S. Zecchi-Orlandini (2010). Skeletal muscle repair/regeneration after accentric contraction-induced damage:effects of S1P.. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 115(1), pp. 190-190, ISSN:1122-6714

C. Sassoli; A. Pini; S. Zecchi-Orlandini; D. Bani; L. Formigli. (2010). Cardiac progenitor-stromal cell interaction: an important player in myocardial development.. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 115(1), pp. 154-154, ISSN:1122-6714

Chellini F; Sassoli C; Nosi D; Deledda C; Tonelli P; Zecchi-Orlandini S; Formigli L; Giannelli M. (2010). Low pulse energy Nd:YAG laser irradiation exerts a biostimulative effect on different cells of the oral microenvironment: "an in vitro study".. LASERS IN SURGERY AND MEDICINE, vol. 6, pp. 527-539, ISSN:0196-8092

E. Meacci; C. Sassoli; F. Bini; R. Squecco; M. Martinesi; L. Formigli; F. Francini (2010). S1P affects skeletal muscle repair /regeneration after eccentric contraction-induced damage. NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY, vol. 382 ( Supplement 1), pp. 21-21, ISSN:0028-1298

E. Meacci; F. Bini; C. Sassoli; M. Martinesi; R. Squecco; F. Chellini; S. Zecchi-Orlandini; F. Francini; L. Formigli (2010). Functional interaction between TRPC1 channel and connexin-43 protein: a novel pathway underlying S1P action on skeletal myogenesis.. CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 67, pp. 4269-4285, ISSN:1420-9071 DOI

Mazzanti, R; Solazzo, M; Fantappie, O; D'Amico, M; Sassoli, C; Tani, A; Cipriani, G; Bogani, C; Pestrin, M; Formigli, L (2009). Breast cancer resistance protein (BCRP) expression and activity in mitochondria of different multiple drug-resistant (MDR) cancer cell lines. CANCER RESEARCH, vol. 69, pp. ...-..., ISSN:0008-5472

C. Sassoli; M.Giannelli; M. Margheri; F. Chellini; A. Tani; P. Tonelli; L. Formigli; S. Zecchi-Orlandini. (2009). Effects of low pulse energy Nd:YAG laser irradiation on cells of the oral microenviroment: an in vitro study.. EUROPEAN JOURNAL OF HISTOCHEMISTRY, pp. 41-42, ISSN:1121-760X

F. Paternostro; C. Sassoli; F. Bini; M. Fasano; A.C. Cappellini (2009). A preliminary study of the effects of a psychomotor education program on balance and coordination in italian preschool-aged children. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. Vol. n° 114, n° 1 suppl. -Atti del 63° Congresso Nazionale della Società Italiana di Anatomia e Istologia, pp. 53-53, ISSN:1122-6714

L. Formigli; C. Sassoli; R. Squecco; F. Bini; M. Martinesi; F. Chellini; G. Luciani; F. Sbrana; S. Zecchi-Orlandini; F. Francini; E. Meacci (2009). Regulation of Transient Receptor Potential Canonical Channel 1 (TRPC1) by sphingosine 1-phosphate in C2C12 myoblasts: relevance for a role of mechanotransduction in skeletal muscle differentiation. JOURNAL OF CELL SCIENCE, vol. 122, pp. 1322-1333, ISSN:0021-9533

C. Sassoli; F. Chellini; D. Nosi ; F. Bini; R. Squecco; E. Meacci; L. Formigli. (2009). Stretch-activated/TRPC1 channels are involved in skeletal myogenesis through the regulation of Cx43 gap junction protein.. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 114(1), pp. 194-194, ISSN:1122-6714

Bini, F; Squecco, R; Tani, A; Sassoli, C; Martinesi, M; Formigli, L; Francini, F; Meacci, E (2009). Effect of sphingolipids on skeletal muscle fiber-damage. THE FEBS JOURNAL, vol. 275, pp. 298-298, ISSN:1742-464X

C. Sassoli; R. Squecco; A. Tani; F. Bini; F. Francini; S. Zecchi-Orlandini; E. Meacci. (2009). Sphingosine 1-phosphate influences satellite cell proliferation and differentiation following eccentric contraction-induced muscle injury.. In: Making muscle in the Embryo and the adult., Columbia University, New York, NY, U.S.A., May 28-June 2, 2009, Making muscle in the Embryo and the adult. Columbia University, USA, vol. P81, pp. 18-19.

M.Giannelli ; F.Chellini ; P. Tonelli ; M. Duvina; C.Sassoli (2009). Low pulse energy Nd:YAG laser therapy for the treatment of peri-implantitis: an in vitro study of the bio-stimulatory effects and mechanisms. CLINICAL ORAL IMPLANTS RESEARCH, vol. 20(9), pp. 944-944, ISSN:0905-7161

M. Solazzo; O. FANTAPPIE'; M. D'Amico; C. Sassoli; A. Tani; G. Cipriani; C. Bogani; L. Formigli; R. Mazzanti (2009). Mitochondrial expression and functional activity of Breast Cancer Resistance Protein in different multiple drug-resistant cell lines. CANCER RESEARCH, vol. 69, pp. 7235-7242, ISSN:0008-5472

A.C. CAPPELLINI; F. PATERNOSTRO; C. SASSOLI; F. BINI ; D. FORMENTI; G. HAUSER (2008). Effects of psychomotor activity on coordination and balance capacities of italian school-aged children. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. Vol. 113, suppl. 1 al fasc. 2, pp. 53-53, ISSN:1122-6714

A.C. Cappellini;F. Paternostro; C. Sassoli;S. Mancini;V. Boddi; D. Formenti (2008). Psychomotor, cognitive and social interactions in elderly and old italians. Preliminary report. ANTHROPOLOGISCHER ANZEIGER, vol. 66-4, pp. 1-6, ISSN:0003-5548

S. Nistri ; T. Persichini ; C. Sassoli ; M. Colasanti; D. Bani (2008). Up-Regulation of Inducible Nitric Oxide Synthase by Relaxin in Rat Coronary Endothelial Cells is Not Mediated by Proinflammatory Cytokines.. THE OPEN BIOLOGY JOURNAL, vol. 1, pp. 1-5, ISSN:1874-1967

R. Squecco; A. Tani; C. Sassoli; F. Bini; L. Formigli; F. Francini; E. Meacci. (2008). Role of sphingolipids on single muscle fiber-damage induced by intense contracture.. THE FEBS JOURNAL, pp. 294-294, ISSN:1742-4658

F. Bini; L. Formigli; C. Sassoli; R. Squecco; M. Martinesi; F. Chellini; S. Zecchi-Orlandini;F. Francini; E. Meacci. (2008). Sphingosine 1-phosphate regulates Transient Receprot Potential Channel 1: relevance for mechanotransduction in myogenesis.. In: First Embo Conference 2008 The molecular and cellular mechanisms regulating skeletal muscle development and regeneration., Sant Feliu de Guixols, Spain, 24-29 September 2008, Richard N. Kitsis, vol. 1, pp. 103-104.

Sbrana, F.; Sassoli, Chiara; Meacci, Elisabetta; Nosi, Daniele; Squecco, Roberta; Paternostro, Ferdinando; Tiribilli, B.; Zecchi, Sandra; Francini, Fabio; Formigli, Lucia (2008). Stress fibers regulates surface tension development and SAC activity in skeletal myoblasts.. In: EMBO Conference, Sant Feliu de Guixol, Spain, 24-29 September 2008, EMBO, vol. First EMBO Conference – The molecular and cellular mechanisms regulating skeletal muscle development and regeneration, pp. 90-91.

F. Bini; R. Squecco; A. Tani; C. Sassoli; M. Martinesi; L. Formigli; F. Francini; E. Meacci (2008). Efects of sphingolipids on skeletal muscle fiber-damage. THE FEBS JOURNAL, vol. 275 (supplement 1), pp. 298-298, ISSN:1742-4658

Sbrana, F; Sassoli, C; Meacci, E; Nosi, D; Squecco, R; Paternostro, F; Tiribilli, B; Zecchi-Orlandini, S; Francini, F; Formigli, L. (2008). Role for stress fiber contraction in surface tension development and stretch-activated channel regulation in C2C12 myoblasts.. AMERICAN JOURNAL OF PHYSIOLOGY. CELL PHYSIOLOGY, vol. 295, pp. 160-172, ISSN:0363-6143

C. Sassoli; A. Tani; D. Nosi; G. Luciani; R. Squecco; E. Meacci; F. Francini; L. Formigli. (2008). Activation of satellite cells following eccentric contraction: role for Sphingosine 1-phosphate (S1P) in mouse skeletal muscle regeneration.. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, pp. 326-326, ISSN:1122-6714

L. Formigli ; E. Meacci ; C. Sassoli ;R. Squecco;D. Nosi ; F. Chellini ; F. Naro; F. Francini ; S. Zecchi . (2007). Cytoskeleton/stretch-activated ion channel interaction regulates myogenic differentiation of skeletal myoblasts.. JOURNAL OF CELLULAR PHYSIOLOGY, vol. 211, pp. 296-306, ISSN:0021-9541

S. ZECCHI; C. SASSOLI; D. NOSI; R. SQUECCO; F. PATERNOSTRO; F. SBRANA (2007). Role for myosin II and stress fiber contraction on membrane tension development and stretch-activated channel (SAC) activation. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. Vol. 112, suppl. 1 al fasc. 2, pp. 20-20, ISSN:1122-6714

M. Martinesi;C. Sassoli;R. Squecco ;S. Zecchi-Orlandini;F. Francini ; L. Formigli; E. Meacci (2007). Cytoskeleton remodelling induced by sphingosine 1-phosphate controls myogenesis through the regulation of Cx43-formed gap junctions.. In: Gap junctional International Conference, Elsinore – Denmark, August 4-9, 2007, Gap junctional International Conference, pp. 1-1.

C. Sassoli; M. Martinesi; R. Squecco; F. Bini ; S. Zecchi-Orlandini; F. Francini; L. Formigli; E. Meacci. (2007). Sphingosine 1-phosphate modulates Transient Receptor Potential Channel 1 (TRCP1) in skeletal muscle cells. Relevance for Connexin43-up-regulation and myogenesis. In: VI International Sphingolipid Meeting., Bilbao, November 22-25, 2007, VI International Sphingolipid Meeting., vol. PB14, pp. 71-71.

C. Sassoli; S. Zecchi; L. Formigli (2007). Differenziamento muscolare scheletrico: meccanismi morfologici e funzionali.. In: Convegno sul tema: Il danno muscolare da sport: nuove frontiere per il recupero morfofunzionale., Pistoia, Italia, 12 ottobre 2007, pp. 1-1.

Nosi, Daniele; Margheri, M.; Sassoli, Chiara; Tani, Alessia; Paternostro, Ferdinando; Squecco, Roberta; Zecchi, Sandra; Formigli, Lucia (2006). Role of actin cytoskeleton in the modulation of stretch-activated channels sensitivity of myoblastic C2C12 cells. In: Third Meeting of the Interuniversity Institute of Myology (IIM), Scuola dello Sport del Coni Roma, Italia, 9-11 Novembre, 2006, Interuniversity Institute of Myology (IIM, pp. 1-1.

S. Zecchi-Orlandini; E. Meacci; F. Francini; C. Sassoli; F. Chellini; L. Formigli. (2006). Role of connexin 43 expression in sphingosine 1-phosphate-induced myoblastic differentiation: not only gap-junctions.. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 111(2), pp. 279-279, ISSN:1122-6714

R. Squecco ;C. Sassoli;F. Nuti;M. Martinesi ;F. Chellini ;D. Nosi ; S. Zecchi; F. Francini ; L. Formigli ;E. Meacci . (2006). Sphingosine 1-phosphate induces myoblast differentiation through Cx43 protein expression: a role for a gap junction-dependent and -independent function.. MOLECULAR BIOLOGY OF THE CELL, vol. 17, pp. 4896-4910, ISSN:1059-1524

M. Solazzo ;O. FANTAPPIE';N. Lasagna ;C. Sassoli ; D. Nosi ;R. Mazzanti. (2006). P-gp localization in mitochondria and its functional characterization in multiple drug-resistant cell lines.. EXPERIMENTAL CELL RESEARCH, vol. 312, pp. 4070-4078, ISSN:0014-4827

M. Solazzo; O. Fantappiè; N. Lasagna; C. Sassoli; R. Mazzanti (2006). Mitochondrial localization and functional expression of P glycoprotein in MDR phenotype expressing cell lines. ANNALS OF ONCOLOGY, vol. 17 (Supplement 1), pp. 35-35, ISSN:0923-7534

R. Squecco; C. Sassoli; F. Nuti; M. Martinesi; F. Chellini; D. Nosi; S. Zecchi; F. Francini; L.Formigli; E. Meacci. (2006). Role of cx43 expression induced by sphingosine 1-phosphate inmyoblast differentiation. In: Third Meeting of the Interuniversity Institute of Myology (IIM), firenxze, 9-11 Novembre, 2006, IIM, pp. 10-10.

L. Formigli; A.M. Perna; E. Meacci; C. Sassoli; L. Cinci; J. Silvertown; S. Zecchi-Orlandini; D. Bani. (2006). Injection of relaxin-producing skeletal myoblasts after myocardial infarction improves cardiac performances by altering the extracellular matrix remodeling and promoting neoangiogenesis.. In: EMBO Conference Series. Cellular and Molecular Basis of Regeneration and Tissue repair 3rd European Conference on Regeneration, Centro Stefano Franscini, Ascona, Switzerland, 10-15 September 2006, EMBO, pp. 20-20.

C. Sassoli; E. Meacci; F. Francini; F. Chellini; R. Squecco; F. Naro; S. Zecchi-Orlandini; L. Formigli. (2006). Stretch-activated channel sensitivity and function during myoblast differentiation.. In: EMBO Conference Series. Cellular and Molecular Basis of Regeneration and Tissue repair 3rd European Conference on Regeneration., Centro Stefano Franscini, Ascona, Switzerland., 10-15 September 2006, EMBO, pp. 46-46.

C. Sassoli; L. Formigli; F. Nuti; R. Squecco; M. Margheri; S. Zecchi-Orlandini; F. Francini; E. Meacci. (2006). Role of connexin 43 in sphingosine 1-phosphate-induced myoblast differetiation: relevance for a novel gap- junction-independent function. In: FEBS Special meeting-Cellular Signaling, Dubrovnik, Croatia, May 26-June 1, 2006, FEBS, pp. 188-188.

E. Sarchielli; C. Sassoli; L. Becciolini; L. Formigli; C. Donati; G. Nemoz; P. Bruni; E. Meacci. (2006). Localization of sphingosine kinase-1 in detergent resistant membranes of C2C12 myoblasts.. In: 5° International Sphingolipid Meeting, Calella (Spain), November 2-4, 2006, Ghidoni Riccardo, vol. N-S Archives of Parmacology -374-, pp. 4-P25-4-P25.

M. Martinesi;C. Sassoli; R. Squecco; S. Zecchi; F. Francini; L. Formigli; E. Meacci (2006). Actin remodelling induced by sphingosine 1-phosphate controls the myogenic differentiation of skeletal muscle cells through the regulation of strecth activated channel activity and gap junctions.. In: Federazione Italiana Scienze della Vita (FISV), Riva del Garda, Italia, 28 Ottobre, 2006, Federazione Italiana Scienze della Vita (FISV), pp. 1-1.

M. Martinesi;C. Sassoli; R. Squecco;S. Zecchi-Orlandini; F. Francini; L. Formigli; E. Meacci (2006). Sphingosine 1-phosphate induces gap junction protein Cx43 expression in murine C2C12 myoblasts. ITALIAN JOURNAL OF BIOCHEMISTRY, pp. 1-1, ISSN:0021-2938

R. Squecco; C. Sassoli; S. Zecchi; L. Formigli; F. Francini (2005). Myoblast differentiation: relevance of cytoskeletal remodelling and SACs activation. II – electrophysiological results. In: Second Meeting of the Interuniversity Institute of Myology (IIM), Casciana Terme (Pisa), Italia, 21-23 Ottobre, 2005, pp. 1-1.

G.Cini ; B. Neri ; A. Pacini ;V. Cesati ; C. Sassoli ;S. Quattrone ; M. D'Apolito ;A. Fazio ;G. Scapagnini ;A. Provenzani ;A. Quattrone. (2005). Antiproliferative activity of melatonin by transcriptional inhibition of cyclin D1 expression: a molecular basis for melatonin-induced oncostatic effects.. JOURNAL OF PINEAL RESEARCH, vol. 39, pp. 12-20, ISSN:0742-3098 DOI

S. Zecchi-Orlandini; C. Sassoli; F. Chellini; E. Meacci; F. Francini; L. Formigli (2005). Stress fiber formation and increased stretch-activated channel sensitivity regulate C2C12 skeletal muscle differentiation. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 110 (1), pp. 292-292, ISSN:1122-6714

L. Formigli ;C. Sassoli; E. Meacci; F. Francini ; S. Zecchi-Orlandini (2005). Stress fiber formation and increased stretch-activated channel sensitivity regulate C2C12 skeletal muscle differentiation. In: EMBO/FEBS worshop: The molecular and cellular mechanisms underlying skeletal muscle formation and repair, Abbaye Royale de Fontevraud, Fontevraud, France, 24th-29th September, 2005, EMBO, vol. P-D5;, pp. 55-55.

C. Sassoli; D. Nosi; E. Meacci; P. Bruni; S. Zecchi; L. Formigli (2005). Myoblast differentiation: relevance of cytoskeletal remodelling and SACs activation. I -Morphofunctional remarks.. In: Second Meeting of the Interuniversity Institute of Myology (IIM), Casciana Terme (Pisa), Italia, 21-23 Ottobre, 2005, Interuniversity Institute of Myology (IIM), pp. 1-1.

L. Formigli; E. Meacci ;C. Sassoli ;F. Chellini ;R. Giannini ;F. Quercioli ;B. Tiribilli ;R. Squecco;P. Bruni ;F. Francini ;S. Zecchi (2005). Sphingosine 1-phosphate induces cytoskeletal reorganization in C2C12 myoblasts: physiological relevance for stress fibres in the modulation of ion current through stretch-activated channels.. JOURNAL OF CELL SCIENCE, vol. 118, pp. 1161-1171, ISSN:0021-9533

R. Squecco;L. Formigli; C. Sassoli; F. Chellini;F. Quercioli;S. Zecchi;B. Tiribilli;F. Francini (2004). Sphingosine 1-phosphate affects the electric properties of the plasmamembrane in C2C12 myoblasts. In: First Meeting of the Interuniversity Institute of Myology (IIM), Montegrotto Terme - Padova, 16 – 18 ottobre, 2004, pp. 1-1.

L. Formigli; D. Nosi; C. Sassoli; F. Chellini; F. Francini; E. Meacci; S. Zecchi Orlandini (2004). Sphingosine 1-phosphate induces stress fibers and focal adhesions formation in C2C12 myoblasts: physiological relevance in the modulation of stretch-activated channels sensitivity. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 109 (1), pp. 112-112, ISSN:1122-6714

F. Chellini; C.Sassoli; D. Nosi; E. Meacci;P. Bruni;L. Formigli;S. Zecchi (2004). Sphingosine 1-phosphate induces cytoskeletal reorganization of the plasmamembrane in C2C12 myoblasts. In: First Meeting of the Interuniversity Institute of Myology(IIM), Montegrotto Terme - Padova, 16 – 18 Ottobre , 2004, Interuniversity Institute of Myology(IIM), pp. 1-1.

A. Pacini ; V. Cesati ;C. Sassoli ;A. Bartolini ;P. Pacini;L. Di Cesare Mannelli (2003). Gi proteins activators: new therapeutic perspectives?. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, pp. 151-151, ISSN:1122-6714

L. Di Cesare Mannelli; C. Sassoli; V. Cesati; A. Pacini (2003). Gi proteins signalling pathway: receptor-independent mechanisms.. In: XIII Convegno Nazionale del Gruppo Italiano per lo Studio della Neuromorfologia (GISN), Bologna, 5-6 Dicembre, pp. 0-0.

S.Nistri ;L. Chiappini;C. Sassoli ;D. Bani. (2003). Relaxin inhibits lipopolysaccharide-induced adhesion of neutrophils to coronary endothelial cells by a nitric oxide-mediated mechanism.. THE FASEB JOURNAL, vol. 17, pp. 2109-2111, ISSN:0892-6638 DOI

L. Chiappini ; S. Nistri ; C. Sassoli; D. Bani (2003). Relaxin inhibits lipopolysaccharide-induced adhesion of neutrophilis to coronary endothelial cells by a nitric oxide-mediated mechanism. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, pp. 45-45, ISSN:1122-6714

C. Sassoli; V. Cesati; F. Paternostro; P. Pacini; A. Pacini (2002). Subcellular localization of HuC mRNA and protein in the hippocampus and cerebellum in the mouse brain. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. Vol 107, suppl. 1 al fasc. 3, pp. 243-243, ISSN:1122-6714

L. PIERI; C. SASSOLI; P. ROMAGNOLI; L. DOMENICI (2002). Use of periodate-lysine-paraformaldehyde for the fixation of multiple antigens in human skin biopsies. EUROPEAN JOURNAL OF HISTOCHEMISTRY, vol. 46, pp. 365-375, ISSN:1121-760X

A. Quattrone; V. Cesati; F. Paternostro; C. Sassoli; F. Mattei; P. Pacini; A. Pacini (2001). A "Normalization Map" for the Local Quantification of Gene Expression in the Brain.. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. Vol 106, suppl. n° 1 al fasc. 3, pp. 216-216, ISSN:1122-6714

A. Pacini ; V. Cesati; C. Sassoli; F. Mattei; A. Quattrone; P. Pacini (2001). Role of Napor in the early steps of apoptosis after cerebral ischemia in the rat. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 106, pp. 189-189, ISSN:1122-6714

A. PACINI; C. SASSOLI; V. CESATI; F. MATTEI; A. QUATTRONE (2001). Subcellular localization of ELAV and CELF proteins in the brain. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 106 suppl.1, pp. 191-191, ISSN:1122-6714

P. Romagnoli; L. Pieri; C. Sassoli (2000). Effect of serum on human Langerhans cells within epidermis in vitro.. In: Joint Meet. Of Society for Cutaneous Ultrastructure Research and Analytic Morphology and Experimental Dermatooncology Group of the AD, Bochum, Germany, 4-6 May 2000, pp. 1-1.

Pacini A.; Quattrone A.; Sassoli C.; Cesati V.; Peruginelli F.; Cozzi A.; Moroni F.; Pacini P (2000). Alteration of the subcellular and tissue distribution of ELAV-type proteins during cerebral ischemia in the rat. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 105, pp. 167-167, ISSN:1122-6714

A. Pacini; V. Cesati; C. Sassoli; A. Pascale; P. Pacini; A. Quattrone (2000). Activation of ELAV-like RNA binding proteins by learning. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 105 suppl.1, pp. 168-168, ISSN:1122-6714

A. Pascale; A. Pacini; V. Cesati; C. Sassoli; X. Nogues; D.L. Alkon; A. Quattrone (2000). Activation of ELAV-like RNA binding proteins by learning.. In: Gruppo di Cooperazione Neuroscienze Molecolari, SIBBM, ABCD, SINS, II Convegno scientifico Meccanismi Molecolari in Neuroscienze, Milano, 14-15 Settembre, pp. 0-0.

Chiara SASSOLI

Biography

Born in Arezzo, Italy on June 11, 1974

EDUCATION AND TRAINING

•1993 – 1999 University of Florence, School of Biological Sciences, Degree of Doctor of Biological Sciences with summa cum laude •1999 – 2000 Internship, Department of Biology and Genetic School of Biological Sciences, University of Florence, Italy

•2000-2001 Guest Researcher , Blanchette Rockefeller Neurosciences Institute della Johns Hopkins University-Gaithersburg-MD-USA •2001 Habilitation as Biologist.

•2001 Fellowship supported by University of Florence for a study on "The effects of melatonin on neoplastic cell culture"

•2001 Fellowship supported by Ente Cassa di Risparmio di Firenze on " Role of HuC ed HuD antigens in learning”

•2002-2005 PhD fellow in “Human morphology and morphogenesis”, University of Florence, Florence, Italy

•2005-2006 Post-doc fellowship supported by Sigma-Tau Company for a study on “The effects of acetyl-carnitine on peripheral nerve regeneration”. Collaboration between the Departments of Anatomy, Histology and Forensic Medicine and of Pharmacological Sciences of the University of Florence, Italy

•2006-2008 Post-doc fellowship for a research on “Skeletal muscle regeneration after exercise-induced injury”; Department of Anatomy, Histology and Forensic Medicine , Medical Faculty,University of Florence, Italy

•2008 Post-doc fellowship for a research on “Meteo-Sport: cardiovascular and skeletal muscle physiological modification after exercise performed in different climate conditions"; Interdipartimental center of Bioclimatology of University of Florence, CNR and SSN of Tuscany Region, Italy.

ACADEMIC POSITION

•2009-2020 Researcher (Human Anatomy) University of Florence,Italy

•21-07-2017 National Scientific Habilitation from Italian Ministry of Education University and Research (ASN-MIUR) as Associate Professor of Human Anatomy

•11-09-2019 ASN-MIUR as Full Professor of Human Anatomy

•Since 2020 Associate Professor of Human Anatomy-University of Florence, Italy

Chiara SASSOLI

Curriculum

RESEARCH ACTIVITIES

Morpho-functional analyses of the cellular and molecular mechanisms involved in tissue repair/regeneration and fibrosis, especially at skeletal and cardiac muscle tissue, and of the effects of different bioactive molecules (sphingolipids, relaxin, platelet-rich plasma), mesenchymal stromal/stem cells and photobiomodulation/Low Level Laser Therapy on tissue healing.

RESEARCH IMPACT METRICS

Co-author of 47 articles published on international scientific journals [(IF average= 4.5; H-index= 24; citations= 1342 -Web of sciences), 1435 (Scopus)]. Participation to numerous national and international congresses bringing own contributions. Member of the Società Italiana di Anatomia e Istologia (SIAI) and Stem Cell Research Italy

SCIENTIFICGRANTS/FUNDINGS Principal Investigator: •2002-2003 "Progetto Giovani Ricercatori"- MURST, “Cell cultures for the analysis of oncostatic effects induced by melatonin” •Since 2009 MIUR (ex 60%) •2015-2017 Ente CR Firenze-Italy (2014-rif.2014/9106) “Skeletal muscle regeneration after damage: role played by mesenchymal stromal cells and telocytes. Translational perspectives in regenerative medicine” •2017-18 FFABR-MIUR Italy Associated Investigator: •2007 PRIN-MUR (Bando 2007-DM n. 1175 del 18 settembre 2007- prot. 2007PPMZRZ_001 - Silvia Nistri) “Cardiovascular hormone relaxin as potential factor for the differentiation of cardioprogenitors and endothelial cells in vitro " partially granted by Università di Firenze. •2008 PRIN-MIUR (2008- DM n. 1407 del 4 -12-2008- prot.20084XRSBS_003) C. Orlacchio- S. Zecchi-Orlandini) " Role of biomaterials in the migration and differentiation of different stem cells: relevance for cardiovascular regenerative medicine.” •2009-2010 research project financed by General Project -Advanced Biomedical Thecnologies -Montespertoli Firenze: "Biological bases for the application of new odontoiatric laser- based therapy for the treatment of parodontitis and peri-implantitis” ( PI Lucia Formigli) •2011 Ente CR Firenze-Italy (2011-rif.2011/1343 Formigli) “ Stem cells and regenerative medicine: new perspectives for the use of bone marrow-mesenchymal stromal cells for skletal muscle repair/regeneration” •2013 Ente CR Firenze-Italy (2013-Formigli) “Bone marrow-mesenchymal stromal cells and biomaterials in regenerative medicne: influence of different microenvironments on cell behaviour and therapeutic perspectives” •2013 Ente CR Firenze-Italy (2013- Squecco) “ Effects of relaxin hormon on cell therapy for the functional recovery of cardiac tissue after ischemic damage: an electrophysiological study” •2018 Ente CR Firenze-Italy (2018- Zecchi #17940) “PRP, biomaterials and LLLT: potential for the improvement of the use of mesenchymal stem/stromal cells in regenerative medicine”

SCIENTIFIC AWARDS

•Cover page Special issue "Mechanical tension controls, Myoblast differentiation" vol 211-issue 2 Journal Cell Physiology - Confocal fluorescence image selected from the article L. Formigli, E. Meacci, C. Sassoli, R. Squecco, D. Nosi, F. Chellini, F. Naro, F. Francini, S. Zecchi . Cytoskeleton/stretch-activated ion channel interaction regulates myogenic differentiation of skeletal myoblasts. JOURNAL OF CELLULAR PHYSIOLOGY, vol. 211, p. 296-306,(2007)(ISSN: 0021-9541)") •Best Poster presentation "C. Sassoli, F. Chellini, A. Pini, B. Mazzanti, D. Nosi, S. Zecchi, L. Formigli. (2012). Morphofunctional interactions between mouse mesenchymal stromal/stem cells and myoblasts in co-culture: clues for skeletal muscle regeneration. In: 3rd Disputationes on Native and Induced Pluripotent Stem Cell Standardization. Florence, Italy, March 19-21, 2012" •Cover page-Cells Tissues Organs 206 (6) 283-380 (2018). Confocal fluorescence image from Chellini F, Tani A, Vallone L, Nosi D, Pavan P, Bambi F, Zecchi-Orlandini S, Sassoli C. Platelet-Rich Plasma and Bone Marrow-Derived Mesenchymal Stromal Cells Prevent TGF-β1-Induced Myofibroblast Generation but Are Not Synergistic when Combined: Morphological in vitro Analysis. Cells Tissues Organs. 2018;206(6):283-295. doi: 10.1159/000501499 •Cells 2020 Best Paper Awards – Chellini F., Tani A., Vallone L., Nosi D., Pavan P., Bambi F., Zecchi Orlandini S., Sassoli C. “Platelet-Rich Plasma Prevents In Vitro Transforming Growth Factor-β1-Induced Fibroblast to Myofibroblast Transition: Involvement of Vascular Endothelial Growth Factor (VEGF)-A/VEGF Receptor-1-Mediated Signaling.” Cells. 2018 Sep 19;7(9):142. Doi: 10.3390/cells7090142.

REVIEWER ACTIVITY

•Expert Opinion on Biological Therapy (Taylor & Francis Medicine, IF (2020): 4.388) •Current Pharmaceutical Design (Bentham Science, IF(2020): 3.116) •Lasers in Surgery & Medicine (Wiley, IF(2020): 4.025) •International Journal of Molecular Sciences (MDPI, IF(2020): 5.924) •International Journal of Stem Cells & Research (SciRes Literature) •Current Molecular Medicine (Bentham Science, IF (2020): 2.222) •Journal of Periodontal Research (Wiley, IF(2020): 4.419) •Histology and Histopathology (F HERNANDEZ, IF(2020): 2.303) •Italian Journal of Anatomy and Embryology (Firenze University Press) •Stem cells international (Hindawi, IF(2020): 5.443) •Cytotechnology (Springer, IF(2020): 2.058) •Cytotherapy (Elsevier, IF(2020) 5.414) •Life Sciences (Elsevier, IF (2020) 5.037) •Antioxidants (MDPI IF(2020) 6.313) •Frontiers in Pharmacology (Frontiers Media SA, IF(2020) 5.811) •International Journal of Radiation Biology (Taylor & Francis IF (2020): 2.694) •International Immunopharmacology (Elsevier IF (2020): 4.932) •Tissue & Cell (Churchill Livingstone IF (2020): 2.466)

EDITORIAL BOARD

•Member of the Editorial Board of Current Molecular Medicine” ISSN: 1566-5240 Bentham Science – IF(2020) 2.222

•Guest Editor for Special Issue in Current Molecular Medicine (“ ISSN: 1566-5240 bentham science – IF(2020) 2.222. Thematic issue: “Fibrosis: from cellular and molecular targets to therapeutic strategies”

• Permanent Associate Editor Frontiers - Stem Cell Research (IF (2020) 6.684)

TEACHING ACTIVITY

•From 2004 Human Anatomy in degree courses in Pharmacy, Medicine and Surgery, Nursing, Logopaedics, Pharmaceutical Chemistry and Technology, Sport Health and Exercise Sciences, Physiotherapy (for blind students), Herbalist techniques, University of Florence.

•Member of the teaching college of PhD degree in Biomedical Sciences, curriculum “Human morphology and morphogenesis”. JOB-

RELATED SKILLS Cell biology (2D and 3D cell cultures, satellite cells and stromal cells from single skeletal myofiber, neonatal cardiomyocytes, muscle/ stromal stem cells co-culture), ex-vivo muscle damage models, morphological analysis (confocal microscopy imaging, immunofluorescence, histochemistry-conventional optical microscopy), molecular biology (nucleic acid extraction from tissues and cells, RT-PCR, gene silencing siRNA, transfection), western blotting, enzymatic assays, low level laser irradiation/photobiomodulation. Research group coordination.

DIGITAL SKILLS Windows; Microsoft Office™ (Word, Excel, PowerPoint); Adobe Photoshop; G-Suite (Gmail, drive, calendar, meet); Cisco WebEx; Teams; Skype; Internet search engines.