Vito CALDERONE

Ruolo attuale:: Professore Associato
SSD:: CHEM-03/A - Chimica generale e inorganica
Afferenza organizzativa:: Dipartimento di Chimica 'Ugo Schiff' - DICUS

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	0554574276
	vito.calderone(AT)unifi.it

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Vito CALDERONE

Orario di ricevimento (aggiornato al 16/10/2012) Previo appuntamento telefonico o email.

Vito CALDERONE

Curriculum

Vito Calderone è nato a Palermo il 5 novembre 1969. Nel 1992 ha conseguito la laurea in Scienze Biologiche presso l'Università degli Studi di Torino. Successivamente ha svolto attività di ricerca presso il Dipartimento di Biologia e Biochimica dell'Università di Bath (Gran Bretagna) nell'ambito della determinazione della struttura cristallografica a raggi X di proteine del latte. Nel triennio 1994-1997 è stato dottorando di ricerca presso l'Università degli studi di Torino ed ha conseguito il titolo di Dottore di Ricerca in Chimica delle Proteine svolgendo gran parte dell'attività di ricerca presso la suddetta Università di Bath (Gran Bretagna). Nel periodo 1997-1999 ha svolto attività di ricerca post-dottorale presso l'unità di cristallografia a raggi X dell'IGBMC a Strasburgo (Francia). Dal 1999 al 2002 è stato assegnista di ricerca presso il Dipartimento di Chimica dell'Università degli Studi di Padova svolgendo attività di ricerca nell'ambito della cristallografia a raggi X di proteine. Dal 2002 al 2006 è stato assegnista di ricerca presso il Dipartimento di Chimica dell'Università degli Studi di Siena svolgendo attività di ricerca nell'ambito della cristallografia a raggi X di proteine. Dal 2006 al 2012 ha svolto attività di ricerca presso il CERM all'Università degli Studi di Firenze dove ha svolto attività di ricerca nell'ambito della cristallografia a raggi X di proteine. Dal 1 marzo 2012 al 31 dicembre 2021 è stato Ricercatore presso il Dipartimento di Chimica della Facoltà di Scienze Matematiche Fisiche e Naturali dell'Università degli Studi di Firenze. Dal 1 gennaio 2022 è Professore Associato.

L'attività di ricerca di Vito Calderone è principalmente rivolta alla biologia strutturale ed in particolare alla determinazione della struttura tridimensionale di proteine di interesse biologico attraverso la cristallografia a raggi X. I principali temi di ricerca riguardano la determinazione strutturale di proteine mitocondriali e di metalloproteine (principalmente proteine coinvolte in processi di trasferimento elettronico e nell'omeostasi dei metalli all'interno della cellula), l'applicazione della cristallografia a raggi X nello 'structure-based drug design' e lo studio strutturale di complessi proteina-proteina mediati da metalli. È coautore di circa 90 pubblicazioni con H-index 31 (2023) su riviste internazionali peer-reviewed ed ha risolto circa 150 strutture cristallografiche di proteine.

Vito CALDERONE

Pubblicazioni

Legenda

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Tesi di Dottorato

Lucarini E.; Pagnotta E.; Righetti L.; Citi V.; Trisolini S.; Ciampi C.; Micheli L.; Martelli A.; Testai L.; Calderone V.; Di Cesare Mannelli L.; Ghelardini C. (2026). Glucotropaeolin-enriched Lepidium sativum L. extract as a novel phytotherapy for tendinopathy: mechanistic insights into pain modulation. BIOMEDICINE & PHARMACOTHERAPY, vol. 194, pp. 0-0, ISSN:1950-6007 DOI

Alessia De Santis, Deborah Grifagni, Andrea Orsetti, Chiara La Guidara, Niccolò Moradei, Koi L. Merz, Elena Lenci, Antonio Rosato, Mariapina D’Onofrio, Andrea Trabocchi, Simone Ciofi-Baffoni, Francesca Cantini, Vito Calderone (2025). Application of the PROTAC-based approach to trigger proteolysis of the Coxsackievirus B3 main protease. In: Convegno Nazionale della Divisione di Chimica dei Sistemi Biologici 2025, Trieste, 18-20/06/2025, DCSB-2025 committee, pp. 0-0.

Alessia De Santis, Deborah Grifagni, Elena Lenci, Andrea Orsetti, Carlo Giorgio Barracchia, Filomena Tedesco, Raffaele Bellini Puglielli, Francesca Lucarelli, Chiara La Guidara, Angela Lauriola, Michael Assfalg, Francesca Cantini, Vito Calderone, Daniele Guardavaccaro, Andrea Trabocchi, Antonio Rosato, MariapinaD’Onofrio, Simone Ciofi-Baffoni (2025). Exploration of PROTAC technology for the development of broad-spectrum antiviral drugs to trigger the proteolysis of the main viral protease. In: Meet THE Innovation – Toscana, cultura della Salute, Meet THE Innovation – Toscana, cultura della Salute committee, pp. 0-0.

Malanho da Silva, Jose; Lanuza, Jose; Bruno, Francesco; Calderone, Vito; Ravera, Enrico (2025). The structure of His15 acetamide-modified hen egg-white lysozyme: a nice surprise from an old friend. ACTA CRYSTALLOGRAPHICA. SECTION F, STRUCTURAL BIOLOGY COMMUNICATIONS, vol. 81, pp. 1-6, ISSN:2053-230X DOI

Lucarini E.; Pagnotta E.; Micheli L.; Trisolini S.; Matteo R.; Righetti L.; Martelli A.; Testai L.; Calderone V.; Di Cesare Mannelli L.; Ghelardini C. (2025). Benefits of Camelina sativa Supplementation in Morphine Treatment: Enhanced Analgesia, Delayed Tolerance and Reduced Gut Side Effects Through PPAR-α Receptor Engagement. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 26, pp. 0-0, ISSN:1422-0067 DOI

Alessia De Santis, Deborah Grifagni, Elena Lenci, Andrea Orsetti, Carlo Giorgio Barracchia, Filomena Tedesco, Raffaele Bellini Puglielli, Francesca Lucarelli, Chiara La Guidara, Angela Lauriola, Michael Assfalg, Francesca Cantini, Vito Calderone, Daniele Guardavaccaro, Andrea Trabocchi, Antonio Rosato, Mariapina D’Onofrio, Simone Ciofi-Baffoni (2024). PROTAC-based approach to develop broad-spectrum antiviral agents triggering the proteolysis of the major viral protease. In: Targeting protein degradation 4, Cranfield University, UK, 15-16/10/2024, Targeting Protein Degradation 4 committee, pp. 0-0.

Costantino, Azzurra; Pham, Lan B. T.; Barbieri, Letizia; Calderone, Vito; Ben‐Nissan, Gili; Sharon, Michal; Banci, Lucia; Luchinat, Enrico (2024). Controlling the incorporation of fluorinated amino acids in human cells and its structural impact. PROTEIN SCIENCE, vol. 33, pp. 1-13, ISSN:0961-8368 DOI Accesso ONLINE all'editore

De Santis, Alessia; Grifagni, Deborah; Orsetti, Andrea; Lenci, Elena; Rosato, Antonio; D'Onofrio, Mariapina; Trabocchi, Andrea; Ciofi-Baffoni, Simone; Cantini, Francesca; Calderone, Vito (2024). A Structural Investigation of the Interaction between a GC-376-Based Peptidomimetic PROTAC and Its Precursor with the Viral Main Protease of Coxsackievirus B3. BIOMOLECULES, vol. 14, pp. 1-18, ISSN:2218-273X DOI

Gigli, Lucia; Silva, José Malanho; Cerofolini, Linda; Macedo, Anjos L.; Geraldes, Carlos F. G. C.; Suturina, Elizaveta A.; Calderone, Vito; Fragai, Marco; Parigi, Giacomo; Ravera, Enrico; Luchinat, Claudio (2024). Machine Learning-Enhanced Quantum Chemistry-Assisted Refinement of the Active Site Structure of Metalloproteins. INORGANIC CHEMISTRY, vol. 63, pp. 10713-10725, ISSN:0020-1669 DOI

Grifagni, Deborah; Lenci, Elena; De Santis, Alessia; Orsetti, Andrea; Barracchia, Carlo Giorgio; Tedesco, Filomena; Bellini Puglielli, Raffaele; Lucarelli, Francesca; Lauriola, Angela; Assfalg, Michael; Cantini, Francesca; Calderone, Vito; Guardavaccaro, Daniele; Trabocchi, Andrea; D’Onofrio, Mariapina; Ciofi-Baffoni, Simone (2024). Development of a GC-376 Based Peptidomimetic PROTAC as a Degrader of 3-Chymotrypsin-like Protease of SARS-CoV-2. ACS MEDICINAL CHEMISTRY LETTERS, vol. 15, pp. 250-257, ISSN:1948-5875 DOI Accesso ONLINE all'editore

Linda Cerofolini, Kristian Vasa, Elisa Bianconi, Maria Salobehaj, Giulia Cappelli, Alice Bonciani, Giulia Licciardi, Anna Pérez-Ràfols, Luis David Padilla Cortés, Sabrina Antonacci, Domenico Rizzo, Enrico Ravera, Caterina Viglianisi, Vito Calderone, Giacomo Parigi, Claudio Luchinat, Antonio Macchiarulo, Stefano Menichetti, Marco Fragai (2024). SOLID-STATE NMR TO DESIGN CHALLENGING PROTEIN-DRUG CONJUGATES. In: 51st National Congress on Magnetic Resonance, Organizing Commitee GIDRM Congress 2024, pp. 17-17.

Alessia De Santis , Deborah Grifagni , Elena Lenci , Andrea Orsetti , Carlo Giorgio Barracchia , Filomena Tedesco , Raffaele Bellini Puglielli , Francesca Lucarelli , Chiara La Guidara , Angela Lauriola , Michael Assfalg , Francesca Cantini , Vito Calderone , Daniele Guardavaccaro , Andrea Trabocchi, Antonio Rosato, Mariapina D'Onofrio , Simone Ciofi-Baffoni (2024). PROTAC-based approach to develop broad-spectrum antiviral agents triggering the proteolysis of the major viral protease. In: EMBO Workshop Ubiquitin and ubiquitin-like proteins in health and disease, Cavtat, Croazia, 27/09-01/10/2024, EMBO 2024 committee, pp. 0-0.

Alessia De Santis, Deborah Grifagni, Elena Lenci, Andrea Orsetti, Carlo Giorgio Barracchia, Filomena Tedesco, Raffaele Bellini Puglielli, Francesca Lucarelli, Angela Lauriola, Michael Assfalg, Francesca Cantini, Vito Calderone, Daniele Guardavaccaro, Andrea Trabocchi, Mariapina D’Onofrio, Simone Ciofi-Baffoni (2024). PROTAC-based approach to develop broad-spectrum antiviral agents triggering the proteolysis of the major viral protease. In: XXVIII Congresso Nazionale della Società Chimica Italiana SCI 2024 Chimica, ELEMENTI DI FUTURO, Milano, 26-30/08/2024, XXVIII Congresso Nazionale SCI2024 committee, pp. 0-0.

Alessia De Santis, Deborah Grifagni, Elena Lenci, Andrea Orsetti, Carlo Giorgio Barracchia, Filomena Tedesco,Raffaele Bellini Puglielli, Francesca Lucarelli, Chiara La Guidara, Angela Lauriola, Michael Assfalg, Francesca Cantini, Vito Calderone, Daniele Guardavaccaro, Andrea Trabocchi, Antonio Rosato, Mariapina D’Onofrio, Simone Ciofi-Baffoni (2024). PROTAC-based approach to develop broad-spectrum antiviral agents triggering the proteolysis of the major viral protease. In: Chianti Workshop 2024, Sesto Fiorentino (Firenze), 16-17/05/2024, Chianti Workshop 2024 committee, pp. 0-0.

Alessia De Santis, Deborah Grifagni, Elena Lenci, Andrea Orsetti, Carlo Giorgio Barracchia, Filomena Tedesco, Raffaele Bellini Puglielli, Francesca Lucarelli, Angela Lauriola, Michael Assfalg, Francesca Cantini, Vito Calderone, Daniele Guardavaccaro, Andrea Trabocchi, Mariapina D’Onofrio, Simone Ciofi-Baffoni (2023). PROTAC-based approach to develop broad-spectrum antiviral agents triggering the proteolysis of the major viral protease. In: National Congress of the Division of Chemistry of Biological Systems, DCSB-2023 committee, pp. 0-0.

Pham, Lan B T; Costantino, Azzurra; Barbieri, Letizia; Calderone, Vito; Luchinat, Enrico; Banci, Lucia (2023). Direct Expression of Fluorinated Proteins in Human Cells for 19F In-Cell NMR Spectroscopy. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 145, pp. 1389-1399, ISSN:0002-7863 DOI

Pham, Bach Tung Lan; Costantino, Azzurra; Barbieri, Letizia; Calderone, Vito; Luchinat, Enrico; Banci, Lucia (2023). Direct Expression of Fluorinated Proteins in Human Cells for 19F In-Cell NMR Spectroscopy. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 145, pp. 1389-1399, ISSN:1520-5126 DOI

Cerofolini, Linda; Vasa, Kristian; Bianconi, Elisa; Salobehaj, Maria; Cappelli, Giulia; Bonciani, Alice; Licciardi, Giulia; Pérez-Ràfols, Anna; Padilla-Cortés, Luis; Antonacci, Sabrina; Rizzo, Domenico; Ravera, Enrico; Viglianisi, Caterina; Calderone, Vito; Parigi, Giacomo; Luchinat, Claudio; Macchiarulo, Antonio; Menichetti, Stefano; Fragai, Marco (2023). Combining Solid-State NMR with Structural and Biophysical Techniques to Design Challenging Protein-Drug Conjugates. ANGEWANDTE CHEMIE, vol. 62, pp. 0-0, ISSN:1521-3773 DOI Accesso ONLINE all'editore

Alessia De Santis, Andrea Orsetti , Deborah Grifagni , Elena Lenci , Francesca Lucarelli , Francesca Cantini , Vito Calderone , Andrea Trabocchi , Mariapina D’Onofrio, Simone Ciofi-Baffoni (2023). An antiviral agent triggering the proteolysis of the main protease from Coxsackievirus B3. In: Autumn Meeting for Young Chemists in Biomedical Sciences AMYC-BIOMED 2023 4th Edition, Firenze, 16-18/10/2023, AMYC-BIOMED 2023 committee, pp. 0-0.

Camponeschi, Francesca; Ciofi-Baffoni, Simone; Calderone, Vito; Banci, Lucia (2022). Molecular Basis of Rare Diseases Associated to the Maturation of Mitochondrial [4Fe-4S]-Containing Proteins. BIOMOLECULES, vol. 12, pp. 1009-1037, ISSN:2218-273X DOI

Del Duca, Sara; Puglia, Anna Maria; Calderone, Vito; Bazzicalupo, Marco; Fani, Renato (2022). Effect of Non-Lethal Selection on Spontaneous Revertants of Frameshift Mutations: The Escherichia coli hisF Case. MICROORGANISMS, vol. 10, pp. 692-710, ISSN:2076-2607 DOI Accesso ONLINE all'editore

Massai, Lara; Grifagni, Deborah; De Santis, Alessia; Geri, Andrea; Cantini, Francesca; Calderone, Vito; Banci, Lucia; Messori, Luigi (2022). Gold-Based Metal Drugs as Inhibitors of Coronavirus Proteins: The Inhibition of SARS-CoV-2 Main Protease by Auranofin and Its Analogs. BIOMOLECULES, vol. 12, pp. 1675-1685, ISSN:2218-273X DOI

Ciani, Caterina; Pérez-Ràfols, Anna; Bonomo, Isabelle; Micaelli, Mariachiara; Esposito, Alfonso; Zucal, Chiara; Belli, Romina; D'Agostino, Vito Giuseppe; Bianconi, Irene; Calderone, Vito; Cerofolini, Linda; Massidda, Orietta; Whalen, Michael Bernard; Fragai, Marco; Provenzani, Alessandro (2022). Identification and Characterization of an RRM-Containing, RNA Binding Protein in Acinetobacter baumannii. BIOMOLECULES, vol. 12, pp. 922-942, ISSN:2218-273X DOI Accesso ONLINE all'editore

Grifagni D.; Calderone V.; Giuntini S.; Cantini F.; Fragai M.; Banci L. (2021). SARS-CoV-2 Mproinhibition by a zinc ion: structural features and hints for drug design. CHEMICAL COMMUNICATIONS, vol. 57, pp. 7910-7913, ISSN:1359-7345 DOI

Ravera, Enrico; Gigli, Lucia; Suturina, Elizaveta A; Calderone, Vito; Fragai, Marco; Parigi, Giacomo; Luchinat, Claudio (2021). A high-resolution view of the coordination environment in a paramagnetic metalloprotein from its magnetic properties. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, vol. 60, pp. 14960-14966, ISSN:1433-7851 DOI

Bellomo, Giovanni; Ravera, Enrico; Calderone, Vito; Botta, Mauro; Fragai, Marco; Parigi, Giacomo; Luchinat, Claudio (2021). Revisiting paramagnetic relaxation enhancements in slowly rotating systems: how long is the long range?. MAGNETIC RESONANCE, vol. 2, pp. 25-31, ISSN:2699-0016 DOI

Reyes Romero A.; Lunev S.; Popowicz G.M.; Calderone V.; Gentili M.; Sattler M.; Plewka J.; Taube M.; Kozak M.; Holak T.A.; Domling A.S.S.; Groves M.R. (2021). A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity. COMMUNICATIONS BIOLOGY, vol. 4, pp. 949-960, ISSN:2399-3642 DOI

Antonio Schirò, Azzurra Carlon, Giacomo Parigi, Garib Murshudov, Vito Calderone, Enrico Ravera, Claudio Luchinat (2020). On the complementarity of X-ray and NMR data. JOURNAL OF STRUCTURAL BIOLOGY. X, pp. 1-20, ISSN:2590-1524 DOI

Lucia Banci, Letizia Barbieri, Vito Calderone, Francesca Cantini, Linda Cerofolini, Simone Ciofi-Baffoni, Isabella C. Felli, Marco Fragai, Moreno Lelli, Claudio Luchinat, Enrico Luchinat, Giacomo Parigi, Mario Piccioli, Roberta Pierattelli, Enrico Ravera, Antonio Rosato, Leonardo Tenori, Paola Turano (2020). Biomolecular NMR at 1.2 GHz. DOI Accesso ONLINE all'editore

Gigli, Lucia; Ravera, Enrico; Calderone, Vito; Luchinat, Claudio (2020). On the Mechanism of Bioinspired Formation of Inorganic Oxides: Structural Evidence of the Electrostatic Nature of the Interaction between a Mononuclear Inorganic Precursor and Lysozyme. BIOMOLECULES, vol. 11, pp. 43-52, ISSN:2218-273X DOI

Cerofolini, Linda; Giuntini, Stefano; Carlon, Azzurra; Ravera, Enrico; Calderone, Vito; Fragai, Marco; Parigi, Giacomo; Luchinat, Claudio (2019). Characterization of PEGylated Asparaginase: New Opportunities from NMR Analysis of Large PEGylated Therapeutics. CHEMISTRY-A EUROPEAN JOURNAL, vol. 25, pp. 1-9, ISSN:0947-6539 DOI

Silva, José Malanho; Giuntini, Stefano; Cerofolini, Linda; Geraldes, Carlos F G C; Macedo, Anjos L; Ravera, Enrico; Fragai, Marco; Luchinat, Claudio; Calderone, Vito (2019). Non-crystallographic symmetry in proteins: Jahn-Teller-like and Butterfly-like effects?. JBIC, pp. 0-0, ISSN:0949-8257 DOI

Malanho Silva, José; Cerofolini, Linda; Giuntini, Stefano; Calderone, Vito; Geraldes, Carlos F.G.C.; Macedo, Anjos L.; Parigi, Giacomo; Fragai, Marco; Ravera, Enrico; Luchinat, Claudio (2019). Metal centers in biomolecular solid-state NMR. JOURNAL OF STRUCTURAL BIOLOGY, vol. 206, pp. 99-109, ISSN:1047-8477 DOI Accesso ONLINE all'editore

Sofia Tsoukalidou, Magdalini Kakou, Ioannis Mavridis, Despoina Koumantou, Vito Calderone, Marco Fragai, Efstratios Stratikos1, Athanasios Papakyriakou, and Dionisios Vourloumis (2019). Exploration of weak zinc-binding groups for the design of inhibitors for the Oxytocinase Subfamily of M1 Aminopeptidases.. BIOORGANIC & MEDICINAL CHEMISTRY, pp. 1-12, ISSN:0968-0896 DOI

Gourdoupis, Spyridon; Nasta, Veronica; Ciofi-Baffoni, Simone; Banci, Lucia; Calderone, Vito (2019). In-house high-energy-remote SAD phasing using the magic triangle: how to tackle the P1 low symmetry using multiple orientations of the same crystal of human IBA57 to increase the multiplicity. ACTA CRYSTALLOGRAPHICA. SECTION D, STRUCTURAL BIOLOGY, vol. 75, pp. 317-324, ISSN:2059-7983 DOI

Calderone, Vito; Fragai, Marco; Luchinat, Claudio (2019). Reviewing the crystal structure of S100Z and other members of the S100 family: Implications in calcium-regulated quaternary structure. In: Vito Calderone, Marco Fragai and Claudio Luchinat. Methods in Molecular Biology, pp. 487-499 Humana Press Inc., ISBN:978-1-4939-9029-0. DOI Accesso ONLINE all'editore

Cerofolini, Linda; Fragai, Marco; Ravera, Enrico; Diebolder, Christoph A.; Renault, Ludovic; Calderone, Vito (2019). Integrative Approaches in Structural Biology: A More Complete Picture from the Combination of Individual Techniques. BIOMOLECULES, vol. 9, pp. 1-12, ISSN:2218-273X DOI Accesso ONLINE all'editore

Francesca Cantini, Vito Calderone, Lorenzo Di Cesare Mannelli, Magdalena Korsak, Leonardo Gonnelli, Oscar Francesconi, Carla Ghelardini, Lucia Banci, and Cristina Nativi (2018). Interaction of Half Oxa-/Half cis-Platin Complex with Human Superoxide Dismutase and Induced Reduction of Neurotoxicity. ACS MEDICINAL CHEMISTRY LETTERS, vol. 9, pp. 1094-1098, ISSN:1948-5875 DOI

Calderone, V.; Fragai, M.; Luchinat, C. (2018). When molecular replacement has no trivial solution: The importance of model editing in human S100Z X-ray structure solution. INORGANICA CHIMICA ACTA, vol. 470, pp. 402-406, ISSN:0020-1693 DOI Accesso ONLINE all'editore

Gourdoupis S, Nasta V, Calderone V, Ciofi-Baffoni S, Banci L. (2018). IBA57 recruits ISCA2 to form a [2Fe-2S] cluster-mediated complex. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 140, pp. 14401-14412, ISSN:0002-7863 DOI Accesso ONLINE all'editore

Fragai, Marco; Comito, Giuseppina; Di Cesare Mannelli, Lorenzo; Gualdani, Roberta; Calderone, Vito; Louka, Alexandra; Richichi, Barbara; Francesconi, Oscar; Angeli, Andrea; Nocentini, Alessio; Gratteri, Paola; Chiarugi, Paola; Ghelardini, Carla; Tadini-Buoninsegni, Francesco; Supuran, Claudiu T; Nativi, Cristina (2017). Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX). JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, pp. 9003-9011, ISSN:1520-4804 DOI

Calderone, V.; Fragai, M.; Gallo, G.; Luchinat, C. (2017). Solving the crystal structure of human calcium-free S100Z: the siege and conquer of one of the last S100 family strongholds. JBIC, pp. 1-8, ISSN:0949-8257 DOI Accesso ONLINE all'editore

Mauro Rinaldelli;Enrico Ravera;Vito Calderone;Giacomo Parigi;Garib N. Murshudov;Claudio Luchinat (2014). Simultaneous use of solution NMR and X-ray data in REFMAC5 for joint refinement/detection of structural differences. ACTA CRYSTALLOGRAPHICA. SECTION D, vol. 70, pp. 958-967, ISSN:1399-0047 DOI

Chakrabarti VS; Mikolajczyk M; Boscaro F; Calderone V. (2014). Human Ind1 expression causes over-expression of E. coli beta-lactamase ampicillin resistance protein.. PROTEIN EXPRESSION AND PURIFICATION, vol. 104C, pp. 26-33, ISSN:1046-5928 DOI

Benny Danilo Belviso;Rocco Caliandro;Dritan Siliqi;Vito Calderone;Fabio Arnesano;Giovanni Natile (2013). Structure of matrix metalloproteinase-3 with a platinum-based inhibitor. CHEMICAL COMMUNICATIONS, vol. 49, pp. 5492-5494, ISSN:1359-7345 DOI

L. Banci;I. Bertini;V. Calderone;S. Ciofi-Baffoni;A. Giachetti;D. Jaiswal;M. Mikolajczyk;M. Piccioli;J. Winkelmann (2013). Molecular view of an electron transfer process essential for iron-sulfur protein biogenesis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 110, pp. 7136-7141, ISSN:0027-8424 DOI

Mattia Mori;Assunta Massaro;Vito Calderone;Marco Fragai;Claudio Luchinat;Alessandro Mordini (2013). Discovery of a New Class of Potent MMP Inhibitors by Structure-Based Optimization of the Arylsulfonamide Scaffold. ACS MEDICINAL CHEMISTRY LETTERS, vol. 4, pp. 565-569, ISSN:1948-5875 DOI

Yael Udi;Marco Fragai;Moran Grossman;Simon Mitternacht;Rina Arad-Yellin;Vito Calderone;Maxime Melikian;Mirco Toccafondi;Igor N. Berezovsky;Claudio Luchinat;Irit Sagi (2013). Unraveling Hidden Regulatory Sites in Structurally Homologous Metalloproteases. JOURNAL OF MOLECULAR BIOLOGY, vol. 425, pp. 2330-2346, ISSN:0022-2836 DOI

Bertrand Czarny;Enrico A. Stura;Laurent Devel;Laura Vera;Evelyne Cassar-Lajeunesse;Fabrice Beau;Vito Calderone;Marco Fragai;Claudio Luchinat;Vincent Dive (2013). Molecular Determinants of a Selective Matrix Metalloprotease-12 Inhibitor: Insights from Crystallography and Thermodynamic Studies. JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, pp. 1149-1159, ISSN:0022-2623 DOI

I.Bertini; V.Calderone; L.Cerofolini; M.Fragai; C.F.Geraldes; P.Hermann; C.Luchinat; G.Parigi; J.M.Teixeira (2012). The catalytic domain of MMP-1 studied through tagged lanthanides. FEBS LETTERS, vol. 586, pp. 557-567, ISSN:0014-5793 DOI

L.Banci; I.Bertini; V.Calderone; C.Cefaro; S.Ciofi-Baffoni; A.Galllo; K.Tokatlidis (2012). An electron-transfer path through an extended disulfide relay system: the case of the redox protein ALR. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 134, pp. 1442-1445, ISSN:0002-7863 DOI

L.Banci; I.Bertini; O.Blaževitš; V.Calderone; F.Cantini; J.Mao; A.Trapananti; M.Vieru; I.Amori; M.Cozzolino; M.T.Carrì (2012). Interaction of Cisplatin with Human Superoxide Dismutase. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 134, pp. 7009-7014, ISSN:0002-7863 DOI

L.Banci; I.Bertini; V.Calderone; C.Cefaro; S.Ciofi-Baffoni; A.Gallo; E.Kallergi; E.Lionaki; C.Pozidis; K.Tokatlidis (2011). Molecular recognition and substrate mimicry drive the electron-transfer process between MIA40 and ALR. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 108 (12), pp. 4811-4816, ISSN:0027-8424 DOI

Jean-Denis Docquier;Manuela Benvenuti;Vito Calderone;Gian-Maria Rossolini;Stefano Mangani (2011). Structure of the extended-spectrum β-lactamase TEM-72 inhibited by citrate. ACTA CRYSTALLOGRAPHICA. SECTION F, STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, vol. 67, pp. 303-306, ISSN:1744-3091 DOI

E. Babini; I. Bertini; V. Borsi; V. Calderone; X. Hu; C. Luchinat; G. Parigi (2011). Structural characterization of human S100A16, a low affinity calcium binder. JBIC, vol. 16, pp. 243-256, ISSN:0949-8257 DOI

J.-D. Docquier;M. Benvenuti;V. Calderone;M. Stoczko;N. Menciassi;G. M. Rossolini;S. Mangani (2010). High-Resolution Crystal Structure of the Subclass B3 Metallo- -Lactamase BJP-1: Rational Basis for Substrate Specificity and Interaction with Sulfonamides. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 54, pp. 4343-4351, ISSN:0066-4804 DOI

V.Borsi; V.Calderone; M.Fragai; C.Luchinat; N.Sarti (2010). Entropic contribution to the linking coefficient in fragment based drug design: a case study.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 27, pp. 4285-4289, ISSN:0022-2623 DOI Accesso ONLINE all'editore

E.Attolino; V.Calderone; E.Dragoni; M.Fragai; B.Richichi; C.Luchinat; C.Nativi (2010). Structure-Based Approach to Nanomolar, Water Soluble Matrix Metalloproteinases Inhibitors (MMPIs). EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 45, pp. 5919-5925, ISSN:0223-5234 DOI

J. D. Docquier;M. Benvenuti;V. Calderone;F. Giuliani;D. Kapetis;F. De Luca;G. M. Rossolini;S. Mangani (2010). Crystal Structure of the Narrow-Spectrum OXA-46 Class D -Lactamase: Relationship between Active-Site Lysine Carbamylation and Inhibition by Polycarboxylates. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 54, pp. 2167-2174, ISSN:0066-4804 DOI

I.Bertini; V.Calderone; M.Fragai; C.Luchinat; E.Talluri (2009). Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin. JOURNAL OF MEDICINAL CHEMISTRY, vol. 15, pp. 4838-4843, ISSN:0022-2623 DOI Accesso ONLINE all'editore

E. Dragoni; V. Calderone; M. Fragai; R. Jaiswal; C. Luchinat; C. Nativi (2009). Biotin-tagged probes for MMP expression and activation: design, synthesis, and binding properties. BIOCONJUGATE CHEMISTRY, vol. 20, pp. 719-727, ISSN:1043-1802 DOI Accesso ONLINE all'editore

L.Banci; I.Bertini; M.Boca; V.Calderone; F.Cantini; S.Girotto; M.Vieru (2009). Structural and dynamic aspects related to oligomineralization of apo SOD1 and its mutants. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 106, pp. 6980-6985, ISSN:1091-6490 DOI

Jean-Denis Docquier;Vito Calderone;Filomena De Luca;Manuela Benvenuti;Francesco Giuliani;Luca Bellucci;Andrea Tafi;Patrice Nordmann;Maurizio Botta;Gian Maria Rossolini;Stefano Mangani (2009). Crystal Structure of the OXA-48 β-Lactamase Reveals Mechanistic Diversity among Class D Carbapenemases. CHEMISTRY & BIOLOGY, vol. 16, pp. 540-547, ISSN:1074-5521 DOI

A. Pavelkova;L. Banci;I. Bertini;V. Calderone;N. D. Malva;I. C. Felli;S. Neri;A. Rosato (2009). Copper(I)-mediated protein-protein interactions result from suboptimal interaction surfaces. THE FEBS JOURNAL, vol. 276, pp. 159-159, ISSN:1742-464X DOI

Banci, Lucia; Bertini, Ivano; Calderone, Vito; Della-Malva, Nunzia; Felli, Isabella C.; Neri, Sara; Pavelkova, Anna; Rosato, Antonio (2009). Copper(I)-mediated protein-protein interactions result from suboptimal interaction surfaces. BIOCHEMICAL JOURNAL, vol. 422, pp. 37-42, ISSN:0264-6021 DOI Accesso ONLINE all'editore

I. Bertini; V. Calderone; M. Fragai; R. Jaiswal; C. Luchinat; M. Melikian; E. Mylonas; D. I. Svergun (2008). Evidence of reciprocal reorientation of the catalytic and hemopexin-like domains of full-length MMP-12. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 130, pp. 7011-7021, ISSN:0002-7863 DOI Accesso ONLINE all'editore

I. Bertini; V. Calderone; M. Fragai; A. Giachetti; M. Loconte; C. Luchinat; M. Maletta; C. Nativi; K. J. Yeo (2007). Exploring the subtleties of drug-receptor interactions: The case of matrix metalloproteinases. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 129, pp. 2466-2475, ISSN:0002-7863 DOI Accesso ONLINE all'editore

I. Bertini; V. Calderone; M. Fragai; C. Luchinat; M. Maletta; K. J. Yeo (2006). Snapshots of the reaction mechanism of matrix metalloproteinases. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, vol. 45, pp. 7952-7955, ISSN:1433-7851 DOI Accesso ONLINE all'editore

Vito Calderone;Costantino Forleo;Manuela Benvenuti;Maria Cristina Thaller;Gian Maria Rossolini;Stefano Mangani (2006). A Structure-based Proposal for the Catalytic Mechanism of the Bacterial Acid Phosphatase AphA belonging to the DDDD Superfamily of Phosphohydrolases. JOURNAL OF MOLECULAR BIOLOGY, vol. 355, pp. 708-721, ISSN:0022-2836 DOI

L.Banci; I.Bertini; V.Calderone; S.Ciofi-Baffoni; S.Mangani; M.Martinelli; P.Palumaa; S.Wang (2006). A hint for the function of human Sco1 from different structures. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 103, pp. 8595-8600, ISSN:0027-8424 DOI

C. Mannino; M. Nievo; F. Machetti; A.Papakyriakou; V. Calderone; M. Fragai; A. Guarna (2006). Synthesis of Bicyclic Molecular Scaffolds (BTAa) for the Development of New Matrix Metalloproteinases Inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 14, pp. 7392-7403, ISSN:1464-3391 DOI Accesso ONLINE all'editore

V. Calderone; M. Fragai; C. Luchinat; C. Nativi; B. Richichi; S. Roelens (2006). A high-affinity carbohydrate-containing inhibitor of matrix metalloproteinases. CHEMMEDCHEM, vol. 1, pp. 598-601, ISSN:1860-7179 DOI

V. CALDERONE; A. CASINI; S. MANGANI; L. MESSORI; P.ORIOLI (2006). Structural Investigation of Cisplatin-Protein Interactions: Selective Platination of His 19 in Cuprozinc Superoxide Dismutase. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, vol. 45, pp. 1267-1269, ISSN:1433-7851 DOI

Michele Lunelli;Maria Luisa Di Paolo;Marianna Biadene;Vito Calderone;Roberto Battistutta;Marina Scarpa;Adelio Rigo;Giuseppe Zanotti (2005). Crystal Structure of Amine Oxidase from Bovine Serum. JOURNAL OF MOLECULAR BIOLOGY, vol. 346, pp. 991-1004, ISSN:0022-2836 DOI

I. Bertini; V. Calderone; M. Cosenza; M. Fragai; Y. M. Lee; C. Luchinat; S. Mangani; B. Terni; P. Turano (2005). Conformational variability of matrix metalloproteinases: beyond a single 3D structure. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 102, pp. 5334-5339, ISSN:0027-8424 DOI Accesso ONLINE all'editore

L.Banci; I.Bertini; V.Calderone; F.Cramaro; R.Del Conte; A. Fantoni; S.Mangani; A.Quattrone; M.S.Viezzoli (2005). A prokaryotic superoxide dismutase paralog lacking two Cu ligands: from largely unstructured in solution to ordered in the crystal. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 102, pp. 7541-7546, ISSN:0027-8424 DOI

V.CALDERONE;C.DEL BIANCO;B.DOLDERER;H.ECHNER; H.J.HARTMANN; C. LUCHINAT;S.MANGANI;U.WESER (2005). The crystal structure of yeast copper thionein: The solution of a long-lasting enigma. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 102, pp. 51-56, ISSN:0027-8424 DOI

L.Banci; M.Benvenuti; I.Bertini; D.Cabelli; V.Calderone; A.Fantoni; S.Mangani; M.Migliardi; M.S.Viezzoli (2005). From an inactive prokaryotic SOD homologue to an active protein through site-directed mutagenesis. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 127, pp. 13287-13292, ISSN:0002-7863 DOI

Calderone, V.; Dolderer, B.; Hartmann, H.-J.; Echner, H.; Luchinat, C.; Del Bianco, C.; Mangani, S.; Weser, U. (2004). Yeast copper thionein: solving a small but long-standing puzzle. ACTA CRYSTALLOGRAPHICA. SECTION A, FOUNDATIONS OF CRYSTALLOGRAPHY, vol. 60, pp. s145-s145, ISSN:0108-7673 DOI

I. Bertini; V. Calderone; M. Fragai; C. Luchinat; S. Mangani; B. Terni (2004). Crystal structure of the catalytic domain of human matrix metalloproteinase 10. JOURNAL OF MOLECULAR BIOLOGY, vol. 336, pp. 707-716, ISSN:0022-2836 DOI Accesso ONLINE all'editore

Calderone V (2004). Practical aspects of the integration of different software in protein structure solution.. ACTA CRYSTALLOGRAPHICA. SECTION D, BIOLOGICAL CRYSTALLOGRAPHY, vol. 60, pp. 2150-2155, ISSN:0907-4449 DOI

Vito Calderone;Costantino Forleo;Manuela Benvenuti;Maria Cristina Thaller;Gian Maria Rossolini;Stefano Mangani (2004). The First Structure of a Bacterial Class B Acid Phosphatase Reveals Further Structural Heterogeneity Among Phosphatases of the Haloacid Dehalogenase Fold. JOURNAL OF MOLECULAR BIOLOGY, vol. 335, pp. 761-773, ISSN:0022-2836 DOI

F. Arnesano.; L. Banci; M. Benvenuti; I. Bertini; V. Calderone; S. Mangani; M.S. Viezzoli (2003). The evolutionarily conserved trimeric structure of CutA1 proteins suggests a role in signal transduction. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, pp. 45999-46006, ISSN:0021-9258 DOI

Vito Calderone;Costantino Forleo;Manuela Benvenuti;Gian M. Rossolini;Stefano Mangani;Maria C. Thaller (2003). Crystal structure of AphA class B acid phosphatase/phosphotransferase from E. coli. In: 11th International Conference on Biological Inorganic Chemistry, J.H. Dawson, vol. 96, pp. 111-111. DOI

Vito Calderone;Michela Trabucco;Andreja Vujičić;Roberto Battistutta;Giorgio Mario Giacometti;Flora Andreucci;Roberto Barbato;Giuseppe Zanotti (2003). Crystal structure of the PsbQ protein of photosystem II from higher plants. EMBO REPORTS, vol. 4, pp. 900-905, ISSN:1469-221X DOI

Vito Calderone;Maria Luisa Di Paolo;Michela Trabucco;Marianna Biadene;Roberto Battistutta;Adelio Rigo;Giuseppe Zanotti (2003). Crystallization and preliminary X-ray data of amine oxidase from bovine serum. ACTA CRYSTALLOGRAPHICA. SECTION D, BIOLOGICAL CRYSTALLOGRAPHY, vol. 59, pp. 727-729, ISSN:0907-4449 DOI

Vito Calderone;Rodolfo Berni;Giuseppe Zanotti (2003). High-resolution Structures of Retinol-binding Protein in Complex with Retinol: pH-induced Protein Structural Changes in the Crystal State. JOURNAL OF MOLECULAR BIOLOGY, vol. 329, pp. 841-850, ISSN:0022-2836 DOI

I. Bertini; V. Calderone; M. Fragai; C. Luchinat; S. Mangani; B. Terni (2003). X-ray structures of binary and ternary enzyme-product-Inhibitor complexes of matrix metalloproteinases. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, vol. 42, pp. 2673-2676, ISSN:1433-7851 DOI Accesso ONLINE all'editore

Costantino Forleo;Manuela Benvenuti;Vito Calderone;Serena Schippa;Jean-Denis Docquier;Maria Cristina Thaller;Gian Maria Rossolini;Stefano Mangani (2003). Expression, purification, crystallization and preliminary X-ray characterization of the class B acid phosphatase (AphA) fromEscherichia coli. ACTA CRYSTALLOGRAPHICA. SECTION D, BIOLOGICAL CRYSTALLOGRAPHY, vol. 59, pp. 1058-1060, ISSN:0907-4449 DOI

Folli C.; Calderone V.; Ramazzina I.; Zanotti G.; Berni R. (2002). Ligand Binding and Structural Analysis of a Human Putative Cellular Retinol-binding Protein. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, pp. 41970-41977, ISSN:0021-9258 DOI

Vito Calderone;Claudia Folli;Alessio Marchesani;Rodolfo Berni;Giuseppe Zanotti (2002). Identification and Structural Analysis of a Zebrafish Apo and Holo Cellular Retinol-binding Protein. JOURNAL OF MOLECULAR BIOLOGY, vol. 321, pp. 527-535, ISSN:0022-2836 DOI

Vito Calderone;Michela Trabucco;Valentina Menin;Alessandro Negro;Giuseppe Zanotti (2002). Cloning of human 3-hydroxyanthranilic acid dioxygenase in Escherichia coli: characterisation of the purified enzyme and its in vitro inhibition by Zn2+. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, vol. 1596, pp. 283-292, ISSN:0167-4838 DOI

Giuseppe Zanotti;Vito Calderone;Marco Beda;Giorgio Malpeli;Claudia Folli;Rodolfo Berni (2001). Structure of chicken plasma retinol-binding protein. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, vol. 1550, pp. 64-69, ISSN:0167-4838 DOI

Folli C.; Calderone V.; Ottonello S.; Bolchi A.; Zanotti G.; Stoppini M.; Berni R. (2001). Identification, retinoid binding, and x-ray analysis of a human retinol-binding protein. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 98, pp. 3710-3715, ISSN:0027-8424 DOI

Vito Calderone;Bernard Chevrier;Michael Van Zandt;Valérie Lamour;Eduardo Howard;Arnaud Poterszman;Patrick Barth;André Mitschler;Jianhui Lu;Dushan M. Dvornik;Gerhard Klebe;Oliver Kraemer;Allan R. Moorman;Dino Moras;Alberto Podjarny (2000). The structure of human aldose reductase bound to the inhibitor IDD384. ACTA CRYSTALLOGRAPHICA. SECTION D, BIOLOGICAL CRYSTALLOGRAPHY, vol. 56, pp. 536-540, ISSN:0907-4449 DOI

Giuffrida MG;Cavaletto M;Giunta C;Neuteboom B;Cantisani A;Napolitano L;Calderone V;Godovac-Zimmermann J;Conti A (1997). The unusual amino acid triplet Asn-Ile-Cys is a glycosylation consensus site in human alpha-lactalbumin.. JOURNAL OF PROTEIN CHEMISTRY, vol. 16, pp. 747-753, ISSN:0277-8033

V. Calderone;M.G. Giuffrida;D. Viterbo;L. Napolitano;D. Fortunato;A. Conti;K.R. Acharya (1996). Amino acid sequence and crystal structure of buffalo α-lactalbumin. FEBS LETTERS, vol. 394, pp. 91-95, ISSN:0014-5793 DOI

E Bertino;GM Prandi;C Fabris;M Cavaletto;S Di Martino;S Cardaropoli;V Calderone;A Conti (1996). Human milk proteins may interfere in ELISA measurements of bovine β-lactoglobulin in human milk. ACTA PAEDIATRICA, vol. 85, pp. 543-549, ISSN:0803-5253 DOI

Vito CALDERONE

Curriculum

Vito Calderone was born in Palermo on November 5^th 1969. In 1992 he got his degree in Biological Sciences at the University of Torino.

Afterwards he has been research assistant at the Department of Biology and Biochemistry of the University of Bath (UK) in the domain of X-ray crystallography of milk proteins. In the period 1994-1997 he has been PhD.student at the University of Torino and became PhD in Protein Chemistry carrying out the majority of his research activity at the above-mentioned University of Bath (UK). Between 1997 and 1999 he has been postdoctoral research fellow at the Crystallography Unit of IGBMC in Strasburg (France). From 1999 to 2002 he has been research assistant at the Department of Chemistry of the University of Padova working on X-ray protein crystallography and structural biology. From 2002 to 2006 he has been research assistant at the Department of Chemistry of the University of Siena carrying out research in the field of X-ray protein crystallography and structural biology. From 2006 to 2012 he has been research assistant at CERM in Florence carrying out research in structural biology and X-ray crystallography. From March 1 2012 to December 31 he has been Assistant Professor at the Department of Chemistry of the University of Florence. From January 1 2022 he is Associate Professor.

The research domain in which Vito Calderone has been involved since his degree is structural biology; in particular his main expertise is the structural determination of proteins of biological interest through X-ray crystallography. His main research topics include structural determination of mytochondrial proteins and metalloproteins (mainly involved in electron transfer processes and in metal trafficking in the cell), application of X-ray crystallography in structure-based drug design and structural studies of metal-mediated protein–protein complexes.

He is co-author of about 90 papers (2023) published in international peer-reviewed scientific journals (H-index = 31) and has solved about 150 X-ray crystallographic structures of proteins.