Personale

Recapiti

Orario di ricevimento

Italiano

Curriculum

Pubblicazioni

Insegnamenti

English

Curriculum

Francesca BIANCHINI

Ruolo attuale:: Professore Associato
SSD:: MEDS-02/A - Patologia generale
Afferenza organizzativa:: Dipartimento di Scienze Biomediche, Sperimentali e Cliniche 'Mario Serio'

Recapiti

	0552751310 - 0552751286
	francesca.bianchini(AT)unifi.it

Francesca BIANCHINI

Curriculum

CURRICULUM VITAE

INFORMAZIONI PERSONALI

NOME Francesca Bianchini

E-MAIL francesca.bianchini@unifi.it

CITTADINANZA ITALIANA

ORCHID NR 0000-0002-5839-4298

DATA e LUOGO DI NASCITA 05/09/1971, Firenze

RUOLO

15/07/2024 Direttrice del Centro Interdipartimentale di ricerca sull’Imaging Biomedico - CIRIB dell'Università degli Studi di Firenze

01/03/2023 Professore Associato per il settore scientifico/ disciplinare MED/04 (Patologia Generale) nell’Università degli Studi di Firenze, incardinata nel Dipartimento di Scienze Biomediche Sperimentali e Cliniche “Mario Serio”.

01/03/2020 -17/01/2023 Ricercatore a tempo determinato di tipo b) (art. 24 c.3-a L. 240/10) nel settore scientifico/disciplinare MED/04 presso l’Università di Firenze.

2018-2020 Ricercatore a tempo determinato di tipo a) (art. 24 c.3-a L. 240/10) nel settore scientifico/disciplinare MED/04 presso l’Università di Firenze.

2016-2018 Dipartimento di Scienze Biomediche Sperimentali e Cliniche ‘Mario Serio’, sezione di Patologia Generale (L.240/2010), Università di Firenze - Assegno di ricerca "Studio della risposta anti-angiogenica in un modello murino di tumore umano con imaging molecolare”

2014-2016 Dipartimento di Scienze Biomediche Sperimentali e Cliniche ‘Mario Serio’, sezione di Patologia Generale (L.240/2010), Università di Firenze - Assegno di ricerca "Nuovi coniugati nanoparticelle-antagonisti RGD come biomarkers dell’angiogenesi”

2012-2014 Dipartimento di Scienze Biomediche Sperimentali e Cliniche ‘Mario Serio’, sezione di Patologia Generale (L.240/2010), e SOD Medicina Nucleare Azienda Ospedaliero/Universitaria Careggi, Incarico di collaborazione coordinata e continuativa “Valutazione dosimetrica e metodologica di un nuovo tracciante PET per amiloide 18FFDDNP”

2010-2012 Dipartimento di Scienze Biomediche Sperimentali e Cliniche ‘Mario Serio’, sezione di Patologia Generale (L.240/2010), Università di Firenze - Borsa di studio post-laurea “Caratterizzazioni funzionali ed applicazioni biologiche in vitro ed in vivo di alcuni antagonisti della sequenza RGD "

2009-2010 Dipartimento di Scienze Biomediche Sperimentali e Cliniche ‘Mario Serio’, sezione di Patologia Generale (L.240/2010), Università di Firenze - Assegno di ricerca "Ruolo del microambiente tumorale nella progressione del carcinoma della prostata"

2008-2009 Dipartimento di Scienze Biomediche Sperimentali e Cliniche ‘Mario Serio’, sezione di Patologia Generale (L.240/2010), Università di Firenze - Assegno di ricerca "Ruolo dell’adiponectina e dei tiazolidenidioni nella rigenerazione muscolare "

2007-2008 Dipartimento di Scienze Biomediche Sperimentali e Cliniche ‘Mario Serio’, sezione di Patologia Generale (L.240/2010), Università di Firenze - Assegno di ricerca "Ruolo dei fibroblasti intratumorali e di alcuni componenti delle matrici extra-cellulari nella invasività di cellule derivate da malattie linfo- e mielo-proliferative"

2004-2005 Dipartimento di Scienze Biomediche Sperimentali e Cliniche ‘Mario Serio’, sezione di Patologia Generale (L.240/2010), Università di Firenze - Assegno di ricerca "Microambiente midollare ed ematopoiesi“

01/01/2003-31/07/2003 Research Fellow nel laboratorio del Prof. Charle N. Serhan del Center for Experimental Therapeutics & Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, U.S.A., per lo svolgimento del progetto intitolato “Identificazione e caratterizzazione funzionale di metaboliti bioattivi dall’acido eicosapentaenoico (Resolvine) e dei loro recettori in cellule infiammatorie”

ISTRUZIONE E FORMAZIONE

2011-2016 Specializzazione in Biochimica Clinica, 50/50 cum Laude,

Università di Tor Vergata – Sede distaccata: Università di Firenze.

01/01/1999 - 31/12/2002 Dottorato di Ricerca in Patologia Sperimentale, XIV ciclo; progetto di ricerca intitolato “Studio delle interazioni dei macrofagi associati al tumore: mediatori pro-infiammatori nel processo di diffusione metastatica” svolto presso il Dipartimento di Patologia e Oncologia Sperimentali dell’Università di Firenze.

Dal 25/03/2002 al 31/12/2002 Visiting Researcher nel laboratorio del Prof. Charle N. Serhan del Center for Experimental Therapeutics & Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, U.S.A.

05/03/1997 Laurea in Scienze Biologiche 110/110 cum Laude

Università di Firenze.

14/07/1990 Diploma di Maturità Classica, Liceo Ginnasio Michelangiolo, Firenze

CAPACITA’ E COMPETENZE

Madrelingua Italiano

altre lingue Inglese

Conoscenza orale, scritta e comprensione: ottima

ATTIVITA’ DIDATTICA

06/A2 – SSD MED/04 – Patologia Generale

Università di Firenze, Corso di Laurea in Farmacia– B054 Titolare del corso di Patologia Generale e Clinica e Terminologia Medica.

Università di Firenze, Corso di Laurea in Medicina E Chirurgia – B120 - Titolare di corso in Patologia Generale e Oncologia (C.I).

Università di Firenze, Corso di Laurea in Odontoiatria e Protesi Dentaria – B125– Titolare di corso in Patologia Generale e Oncologia (C.I).

Università di Firenze, Corso di Laurea in Biotecnologie Mediche e Farmaceutiche – B121 – Titolare del corso di Patologia Sperimentalee Imaging Biomedico in Patologia.

DOTTORATO IN SCIENZE BIOMEDICHE DELL’UNIVERSITÀ DI FIRENZE

2019- oggi Membro del collegio dei docenti

2023-2025Responsabile Scientifico di una Borsa di Dottorato Ciclo XXXVIII in Scienze Biomediche dell'Università di Firenze, nell'ambito dell'iniziativa NEXT GENERATION EU e delle risorse del Piano Nazionale di Ripresa e Resilienza (PNRR), dal titolo: “Il crosstalk stroma-tumore nel microambiente tumorale come bersaglio nelle terapie personalizzate dell'RNA” Centri Nazionali – CN_3 - CUP: B13C22001010001.

ATTIVITÀ GESTIONALE NELL’AMBITO DEI CdS

2022: Delegato all’Orientamento in ingresso CdLM Biotecnologie Mediche e Farmaceutiche LM-9

premi 2000 Progetto Giovani Ricercatori: riceve un finanziamento per il progetto dal titolo: “Caratterizzazione di un’attività pro-metastatica secreta dai macrofagi attivati”

ATTIVITÀ DI TRASFERIMENTO TECNOLOGICO - SPIN-OFF

2015 – 2022 Socio fondatore della start-up innovativa IMADROM srl, spin-off riconosciuto dall’Università degli Studi di Firenze.

ABILITAZIONE SCIENTIFICA NAZIONALE (ASN)

06/A2 - PATOLOGIA GENERALE E PATOLOGIA CLINICA. VALIDO DAL 01/08/2017 AL 01/08/2023 (art. 16, comma 1, Legge 240/10)

06/N1 - SCIENZE DELLE PROFESSIONI SANITARIE E DELLE TECNOLOGIE MEDICHE APPLICATE. VALIDO DAL 31/03/2017 AL 31/03/2023 (art. 16, comma 1, Legge 240/10)

ORGANIZZAZIONE O PARTECIPAZIONE A CONVEGNI SCIENTIFICI

Organizzazione del10th Young Meeting: PATHOBIOLOGY: FROM MOLECULAR DISEASE TO CLINICAL APPLICATION, Società Italiana di Patologia e Medicina Traslazionale (SIPMeT) 13th-14th Settembre 2019 - Università di Firenze.

---------

Relazione orale - “Tumor Microenvironment Heterogeneity in Cancer Progression: Challenge or Opportunity”. Title: “Novel αvβ6-integrin ligands conjugated with nintedanib reduce TGFβ-induced EMT of human non-small cell lung cancer”. Cancers / 2nd International Electronic Conference (IECC) 14-16/02/2022

Relazione orale - cAmpRGD-Sunitinib Conjugates as Integrin Targeted Delivery Strategy for Inhibition of Angiogenesis and Tumor Growth. 33° CONGRESSO NAZIONALE SIPMeT, Società Italiana di Patologia e Medicina Traslazionale, Montesilvano (PE), 4-5-6 Ottobre 2016.

Relazione orale - ¹¹¹InDOTA-aminoproline-RGD based cyclic semipeptides (cAmpRGD) for SPECT Molecular Imaging of Melanoma. Società Italiana di Patologia e Medicina Traslazionale (SIPMeT) Young Scientific Meeting, Alba 11-12 September 2015.

Relazione orale - Selective targeting of melanoma cells and efficient cellular internalization using RGD-functionalized gold nanoparticles. HOT TOPICS IN MELANOMA & NON-MELANOMA. SKIN CANCER Florence 16-18/04/2015.

Relazione orale -Expression of IL-1 and IL-6 receptors contributes to liver colonization of B16 murine melanoma cells: A possible dietetic target. II International Workshop on Lipid Mediators Valladolid, Spain, June 12-13, 2008.

Relazione orale - Epigenetic control of invasiveness in B16 melanoma cells: role of inflammatory cytokines. Second Chianti Meeting on Proteases. 16-20 Maggio 2004, Pontignano (Siena).

Public Engagement

Referente di Dipartimento progetto Lu.Ra.Ma, Luce Radiazione Materia nella medicina di precisione, Bando Unifi Extra 2023

RESPONSABILITA' DI STUDI E RICERCHE SCIENTIFICHE AFFIDATI DA QUALIFICATE ISTITUZIONI PUBBLICHE O PRIVATE

2019- Responsabile Scientifico e Assegnatario di finanziamento: Sintesi di nuovi agenti anti-fibrotici per il trattamento della Fibrosi Polmonare Idiopatica 02/08/2019 Fondazione CR Firenze.

2018- oggiResponsabile Scientifico e Assegnatario di finanziamento di ateneo per progetti di ricerca ex60%. I progetti si articolano nell'ambito del ruolo delle integrine nelle interazioni fra cellule tumorali e matrice extracellulare, e sulla relazione fra TGFb e fibrosi associata al tumore.

RESPONSABILITA' SCIENTIFICA PER PROGETTI DI RICERCA INTERNAZIONALI E NAZIONALI, AMMESSI AL FINANZIAMENTO SULLA BASE DI BANDI COMPETITIVI CHE PREVEDANO LA REVISIONE TRA PARI

Responsabile Scientifico e Assegnatario di finanziamento: PRIN 2022 Innovative therapeutic interventions against Idiopathic Pulmonary Fibrosis, Principal Investigator.

Responsabile Scientifico e Assegnatario di finanziamento: Bando di Ateneo per il finanziamento competitivo di progetti elaborati da Ricercatori a Tempo Determinato dell'Università di Firenze - Anno 2020/2021- co-PI Romina Nassini (RTDb) e Francesca Bianchini (RTDb). Titolo progetto “Cancer-induced bone pain in a murine model of breast carcinoma: role of transient receptor potential channels”.

Responsabile Scientifico e Assegnatario di finanziamento: PNRR-CN3 (Centro Nazionale di Ricerca Sviluppo di terapia genica e farmaci con tecnologia a RNA) Spoke 2 (Cancer): Cross-talk stroma-tumore nel microambiente tumorale come target nelle terapie personalizzate ad RNA.

PARTECIPAZIONE AD ATTIVITÀ DI RICERCA ATTRAVERSO COLLABORAZIONI DI LIVELLO NAZIONALE O INTERNAZIONALE

collaborazione con la Prof.ssa Vasiliki Sarli, Università di Salonicco, Grecia

collaborazione con la Prof.ssa Erem Biliensoy, Hacettepe University, Ankara, Turchia.

collaborazione con la Prof.ssa Franca Zanardi, ed il Prof. Andrea Sartori, Università di Parma, e con il Prof. Roberto Fiammengo, Università di Verona, Italia

collaborazione con il Prof. Lido Calorini, la Prof.ssa Chiara Nediani, il Prof. Alberto Pupi, ed il Prof. Mario Del Rosso, Università di Firenze.

AFFILIAZIONE A SOCIETÀ SCIENTIFICHE E CENTRI DI RICERCA

2015-oggi Membro del Centro Interdipartimentale per lo Sviluppo Preclinico dell'Imaging Molecolare (C.I.S.P.I.M.) dell’Università di Firenze.

2015-oggi Membro della Società Italiana di Patologia Generale e Medicina Traslazionale (SIPMeT) /Association for Molecular Pathology (AMP).

2016-oggi Membro della Società Italiana di Cancerologia (SIC) / American Association for Cancer Research (AACR).

2023-oggi Membro della European Society for Molecular Imaging (ESMI)

ATTIVITÀ EDITORIALE

2020 Traduzione della prefazione e dei capitoli 2 e 3 del libro: Basic Pathology, 5th Edition Copyright © 2016 by Sunil R. Lakhani, Caroline Finlayson, Susan Dilly, Mitesh Gandhi CRC Press - Taylor & Francis Group. Edizione italiana: © 2020 CEA - Casa Editrice Ambrosiana, (Zanichelli editore S.p.A).

dati bibliometrici relativi alla produzione scientifica

Numero totale delle pubblicazioni: 102

Numero totale delle citazioni (escluse auto-citazioni): 3126

H index totale: 33

Impact factor totale (dati del 2022): 640

Impact factor medio: 6,27

Elenco completo delle Pubblicazioni

Landini L, Marini M, Souza Monteiro de Araujo D, Romitelli A, Montini M, Albanese V, Titiz M, Innocenti A, Bianchini F, Geppetti P, Nassini R, De Logu F. Schwann Cell Insulin-like Growth Factor Receptor Type-1 Mediates Metastatic Bone Cancer Pain in Mice. Brain Behav Immun. 2023 Mar 18:S0889-1591(23)00070-3. doi: 10.1016/j.bbi.2023.03.013. Epub ahead of print. PMID: 36940752. [I.F. 19.227]
Andreucci E, Bugatti K, Peppicelli S, Ruzzolini J, Lulli M, Calorini L, Battistini L, Zanardi F, Sartori A, Bianchini F, Nintedanib-αVβ6 Integrin Ligand Conjugates Reduce TGFβ-Induced EMT in Human Non-Small Cell Lung Cancer. International Journal of Molecular Sciences. 2023; 24(2):1475. https://doi.org/10.3390/ijms24021475 [I.F. 6.208]
Bugatti K, Sartori A, Battistini L, Ruzzolini J, Nediani C, Curti C, Bianchini F,, Zanardi F. Nintedanib‐αVβ3 Integrin Ligand Dual‐Targeting Conjugates towards Precision Treatment of Melanoma. European Journal of Organic Chemistry. 2022, Issue 45, 6 December 2022, 1-10. https://doi.org/10.1002/ejoc.202200765. [I.F. 3.261]
Peppicelli S, Ruzzolini J, Lulli M, Biagioni A, Bianchini F, Caldarella A, Nediani C, Andreucci E, Calorini L. Extracellular Acidosis Differentially Regulates Estrogen Receptor β-Dependent EMT Reprogramming in Female and Male Melanoma Cells. Int J Mol Sci. 2022 Dec 6;23(23):15374. doi: 10.3390/ijms232315374. PMID: 36499700; PMCID: PMC9736857. [I.F. 6.208]
Peri S, Ruzzolini J, Urciuoli S, Versienti G, Biagioni A, Andreucci E, Peppicelli S, Bianchini F, Bottari A, Calorini L, Nediani C, Magnelli L, Papucci L. An Oleocanthal-Enriched EVO Oil Extract Induces the ROS Production in Gastric Cancer Cells and Potentiates the Effect of Chemotherapy. Antioxidants (Basel). 2022 Sep 7;11(9):1762. doi: 10.3390/antiox11091762. [I.F. 7.675]
Innocenti R, Dallari C, Lenci E, Pavone FS, Bianchini F, Credi C, Trabocchi A. Design, synthesis and evaluation of RGD peptidomimetic - Gold nanostar conjugates as M21 cell adhesion inhibitors. Bioorg Chem. 2022 Sep;126:105873. doi: 10.1016/j.bioorg.2022.105873. [I.F. 5.307].
Calugi L, Lenci E, Bianchini F, Contini A, Trabocchi A. Modular synthesis of 2,4-diaminoanilines as CNS drug-like non-covalent inhibitors of asparagine endopeptidase. Bioorg Med Chem. 2022 Jun 1;63:116746. doi: 10.1016/j.bmc.2022.116746. [IF 2.940]
Bugatti K, Andreucci E, Monaco N, Battistini L, Peppicelli S, Ruzzolini J, Curti C, Zanardi F, Bianchini F, Sartori A. Nintedanib-Containing Dual Conjugates Targeting αVβ6 Integrin and Tyrosine Kinase Receptors as Potential Antifibrotic Agents. ACS Omega. 2022 May 17;7(21):17658-17669. doi: 10.1021/acsomega.2c00535. [IF 4.132]
Ippolito L, Comito G, Parri M, Iozzo M, Duatti A, Virgilio F, Lorito N, Bacci M, Pardella E, Sandrini G, Bianchini F, Damiano R, Ferrone L, la Marca G, Serni S, Spatafora P, Catapano CV, Morandi A, Giannoni E, Chiarugi P. Lactate Rewires Lipid Metabolism and Sustains a Metabolic-Epigenetic Axis in Prostate Cancer. Cancer Res. 2022 Apr 1;82(7):1267-1282. doi: 10.1158/0008-5472.CAN-21-0914. [IF 13.312]
Baldini L, Lenci E, Bianchini F, Trabocchi A. Identification of a Common Pharmacophore for Binding to MMP2 and RGD Integrin: Towards a Multitarget Approach to Inhibit Cancer Angiogenesis and Metastasis. Molecules. 2022 Feb 12;27(4):1249. doi: 10.3390/molecules27041249. [I.F. 4.927]
Andreucci E, Peppicelli S, Ruzzolini J, Bianchini F, Calorini L. Physicochemical aspects of the tumour microenvironment as drivers of vasculogenic mimicry. Cancer Metastasis Rev. 2022 Oct 13. doi: 10.1007/s10555-022-10067-x. [IF 9.237].
Chatzisideri, T., Leonidis, G., Karampelas, T., Skavatsou, E., Velentza-Almpani, A., Bianchini F, Tamvakopoulos, C., Sarli, V. Integrin-Mediated Targeted Cancer Therapy Using c(RGDyK)-Based Conjugates of Gemcitabine J Med Chem. 2022 Jan 13;65(1):271-284. doi: 10.1021/acs.jmedchem.1c01468. Epub 2021 Dec 30. PMID: 34967607. [I.F. 8.039].
Sartori, A., Bugatti, K., Portioli, E., Baiula, M., Casamassima, I., Bruno, A., Bianchini F, Curti, C., Zanardi, F., Battistini, L.New 4-aminoproline-based small molecule cyclopeptidomimetics as potential modulators of α4β1 integrin Molecules. 2021 Oct; 26(19): 6066. Published online 2021 Oct 7. doi: 10.3390/molecules26196066 [I.F. 4.927]
Ruzzolini, J., Chioccioli, S., Monaco, N., Peppicelli, S., Andreucci, E., Urciuoli, S., Romani, A., Luceri, C., Tortora, K., Calorini, L., Caderni, G., Nediani, C., Bianchini F. Oleuropein-rich leaf extract as a broad inhibitor of tumour and macrophage iNOS in an apc mutant rat model Antioxidants (Basel) 2021 Oct; 10(10): 1577. Published online 2021 Oct 6. doi: 10.3390/antiox10101577. [I.F. 7.675]
Andreucci, E., Margheri, F., Peppicelli, S., Bianchini F, Ruzzolini, J., Laurenzana, A., Fibbi, G., Bruni, C., Bellando-Randone, S., Guiducci, S., Romano, E., Manetti, M., Matucci-Cerinic, M., Calorini, L. Glycolysis-derived acidic microenvironment as a driver of endothelial dysfunction in systemic sclerosis Rheumatology (Oxford). 2021;60 (10):4508-4519. doi: 10.1093/rheumatology/keab022. PubMed PMID:33471123 [I.F. 7.046].
Biagioni, A., Chillà, A., Del Rosso, M., Fibbi, G., Scavone, F., Andreucci, E., Peppicelli, S., Bianchini F, Calorini, L., Li Santi, A., Ragno, P., Margheri, F., Laurenzana, A. CRISPR/Cas9 uPAR Gene Knockout Results in Tumor Growth Inhibition, EGFR Downregulation and Induction of Stemness Markers in Melanoma and Colon Carcinoma Cell Lines. Front Oncol. 2021; 11: 663225. Published online 2021 May 14. doi: 10.3389/fonc.2021.663225. [I.F. 5.738].
Chatzisideri, T., Dalezis, P., Leonidis, G., Bousis, S., Trafalis, D., Bianchini F, Sarli, V. Synthesis and biological studies of c(RGDyK) conjugates of cucurbitacins. Future Med Chem. 2021 May;13(10):877-895. doi: 10.4155/fmc-2020-0309. Epub 2021 Apr 16. PMID: 33858195. [I.F. 4.767]
Biagioni, A., Laurenzana, A., Menicacci, B., Peppicelli, S., Andreucci, E., Bianchini F, Guasti, D., Paoli, P., Serratì, S., Mocali, A., Calorini, L., Del Rosso, M., Fibbi, G., Chillà, A., Margheri, F. uPAR-expressing melanoma exosomes promote angiogenesis by VE-Cadherin, EGFR and uPAR overexpression and rise of ERK1,2 signaling in endothelial cells. Cell Mol Life Sci. 2021; 78(6): 3057–3072. Published online 2020 Nov 25. doi: 10.1007/s00018-020-03707-4 PMCID: PMC8004497.[I.F. 9.234].
Armanetti, P., Chillà, A., Margheri, F., Biagioni, A., Menichetti, L., Margheri, G., Ratto, F., Centi, S., Bianchini F, Severi, M., Traversi, R., Bani, D., Lulli, M., Del Rosso, T., Mocali, A., Rovida, E., Del Rosso, M., Fibbi, G., Laurenzana, A. Enhanced Antitumoral Activity and Photoacoustic Imaging Properties of AuNP-Enriched Endothelial Colony Forming Cells on Melanoma. Adv Sci (Weinh) 2021 Feb; 8(4): 2170017. Published online 2021 Feb 17. doi: 10.1002/advs.202170017. PMCID: PMC7887581. [I.F. 17.521].
Margheri, F., Maggi, L., Biagioni, A., Chillà, A., Laurenzana, A., Bianchini F, Bani, D., Capone, M., Mazzoni, A., Rossi, M.C., Liotta, F., Cosmi, L., Giani, T., Cimaz, R., Fibbi, G., Annunziato, F., Del Rosso, M. Th17 lymphocyte-dependent degradation of joint cartilage by synovial fibroblasts in a humanized mouse model of arthritis and reversal by secukinumab. Eur J Immunol 2021, 51(1), pp. 220–230. [I.F. 6.688]
Andreucci, E., Peppicelli, S., Ruzzolini, J., Bianchini F, Biagioni, A., Papucci, L., Magnelli, L., Mazzanti, B., Stecca, B., Calorini, L. The acidic tumor microenvironment drives a stem-like phenotype in melanoma cells. J Mol Med. J Mol Med (Berl) 2020; 98(10): 1431–1446. Published online 2020 Aug 15. doi: 10.1007/s00109-020-01959-y PMCID: PMC7525286. [I.F. 5.606].
Dordoni, F., Scarpi, D., Bianchini F, Contini, A., Occhiato, E.G. Enantioselective Synthesis of cis and trans 4-Aminopipecolic Acids as γ-Amino Acids for the Construction of Cyclic RGD-Containing Peptidomimetics Antagonists of αVβ3 Integrin. Eur J Org Chem 2020, 2020(28), pp. 4371–4383[I.F. 3.261].
Calvani, M., Bruno, G., Dabraio, A., Subbiani, A., Bianchini F, Fontani, F., Casazza, G., Vignoli, M., De Logu, F., Frenos, S., Filippi, L., Favre, C. β3-Adrenoreceptor Blockade Induces Stem Cells Differentiation in Melanoma Microenvironment. Int J Mol Sci 2020, 21(4), 1420. [I.F. 6.208]
Peppicelli, S., Andreucci, E., Ruzzolini, J., Bianchini F, Nediani, C., Supuran, C.T., Calorini, L. The Carbonic Anhydrase IX inhibitor SLC-0111 as emerging agent against the mesenchymal stem cell-derived pro-survival effects on melanoma cells. Journal of Enzyme Inhibition and Medicinal Chemistry (2020) 35 (1), pp. 1185-1193. [I.F. 5.756]
Ruzzolini, J., Laurenzana, A., Andreucci, E., Peppicelli, S., Bianchini F, Carta, F., Supuran, C.T., Romanelli, M.N., Nediani, C., Calorini, L.A potentiated cooperation of carbonic anhydrase IX and histone deacetylase inhibitors against cancer Journal of Enzyme Inhibition and Medicinal Chemistry (2020) 35 (1), pp. 391-397. [I.F. 5.756]
Peppicelli S. Andreucci E, Ruzzolini J, Bianchini F and Calorini L. FDG uptake in cancer is still a story to be debated. Theranostics. 2020 Feb 6;10(7):2944-2948. doi: 10.7150/thno.40599. [IF 11.600]
Ruzzolini J, Peppicelli S, Bianchini F, Andreucci E, Urciuoli S, Romani A, Tortora K, Caderni G, Nediani C, Calorini L. Cancer Glycolytic Dependence as a New Target of Olive Leaf Extract. Cancers (Basel). 2020 Jan 29;12(2). pii: E317. doi: 10.3390/cancers12020317. [IF 6.575]
Peppicelli S, Ruzzolini J, Andreucci E, Bianchini F, Kontos F, Yamada T, Ferrone S, Calorini L. Potential role of HLA class I antigens in the glycolytic metabolism and motility of melanoma cells. Cancers (Basel). 2019;11(9):1249. Published 2019 Aug 26. doi:10.3390/cancers11091249. [IF 6.575]
Peppicelli S, Ruzzolini J, Bianchini F, Andreucci E, Nediani C, Laurenzana A, Margheri F, Fibbi G, Calorini L. Anoikis Resistance as a Further Trait of Acidic-Adapted Melanoma Cells. J Oncol. 2019 Jun 2; 2019:8340926. doi: 10.1155/2019/8340926. eCollection 2019. PubMed PMID: 31275384; PubMed Central PMCID: PMC6582804. [IF 4.501]
Andreucci E, Ruzzolini J, Peppicelli S, Bianchini F, Laurenzana A, Carta F, Supuran CT, Calorini L. The carbonic anhydrase IX inhibitor SLC-0111 sensitises cancer cells to conventional chemotherapy. J Enzyme Inhib Med Chem. 2019 Dec;34(1):117-123. doi: 10.1080/14756366.2018.1532419. PMID: 30362384; PMCID: PMC6211231. [I.F. 5.756]
Bacci M, Lorito N, Ippolito L, Ramazzotti M, Luti S, Romagnoli S, Parri M, Bianchini F, Cappellesso F, Virga F, Gao Q, Simões BM, Marangoni E, Martin LA, Comito G, Ferracin M, Giannoni E, Mazzone M, Chiarugi P, Morandi A. Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer. Cell Rep. 2019 Jul 2;28(1):104-118.e8. doi: 10.1016/j.celrep.2019.06.010. PubMed PMID: 31269432. [IF 9.995]
Lenci E, Innocenti R, Di Francescantonio T, Menchi G, Bianchini F, Contini A, Trabocchi A. Identification of highly potent and selective MMP2 inhibitors addressing the S1' subsite with d-proline-based compounds. Bioorg Med Chem. 2019 May 1;27(9):1891-1902. doi: 10.1016/j.bmc.2019.03.043. Epub 2019 Mar 22. PubMed PMID: 30926311. [IF 2.940]
Calvani M, Bruno G, Dal Monte M, Nassini R, Fontani F, Casini A, Cavallini L, Becatti M, Bianchini F, De Logu F, Forni G, la Marca G, Calorini L, Bagnoli P, Chiarugi P, Pupi A, Azzari C, Geppetti P, Favre C, Filippi L. β(3) -Adrenoceptor as a potential immuno-suppressor agent in melanoma. Br J Pharmacol. 2019 Jul;176(14):2509-2524. doi: 10.1111/bph.14660. Epub 2019 May 9. PubMed PMID: 30874296; PubMed Central PMCID: PMC6592854. [IF. 9.473]
Bianchini F, De Santis A, Portioli E, Russo Krauss I, Battistini L, Curti C, Peppicelli S, Calorini L, D'Errico G, Zanardi F, Sartori A. Integrin-targeted AmpRGD sunitinib liposomes as integrated antiangiogenic tools. Nanomedicine. 2019 Jun;18:135-145. doi: 10.1016/j.nano.2019.02.015. Epub 2019 Mar 6. PubMed PMID: 30849548. [first, IF 6.096]
Bianchini F, Portioli E, Ferlenghi F, Vacondio F, Andreucci E, Biagioni A, Ruzzolini J, Peppicelli S, Lulli M, Calorini L, Battistini L, Zanardi F, Sartori A. Cell-targeted c(AmpRGD)-sunitinib molecular conjugates impair tumor growth of melanoma. Cancer Lett. 2019 Apr 1; 446:25-37. doi: 10.1016/j.canlet.2018.12.021. Epub 2019 Jan 11. PubMed PMID: 30639534. [first and co-corresponding, IF 9.756]
Ruzzolini J, Peppicelli S, Andreucci E, Bianchini F, Scardigli A, Romani A, La Marca G, Nediani C, Calorini L. Oleuropein, the Main Polyphenol of Olea europaea Leaf Extract, Has an Anti-Cancer Effect on Human BRAF Melanoma Cells and Potentiates the Cytotoxicity of Current Chemotherapies. Nutrients. 2018 Dec 8;10(12). pii: E1950. doi: 10.3390/nu10121950. PubMed PMID: 30544808; PubMed Central PMCID: PMC6316801. [IF 6.706]
Calvani M, Cavallini L, Tondo A, Spinelli V, Ricci L, Pasha A, Bruno G, Buonvicino D, Bigagli E, Vignoli M, Bianchini F, Sartiani L, Lodovici M, Semeraro R, Fontani F, De Logu F, Dal Monte M, Chiarugi P, Favre C, Filippi L. β3-Adrenoreceptors Control Mitochondrial Dormancy in Melanoma and Embryonic Stem Cells. Oxid Med Cell Longev. 2018 Nov 13; 2018:6816508. doi: 10.1155/2018/6816508. eCollection 2018. PubMed PMID: 30538804; PubMed Central PMCID: PMC6258109. [IF 7.310]
Andreucci E, Pietrobono S, Peppicelli S, Ruzzolini J, Bianchini F, Biagioni A, Stecca B, Calorini L. SOX2 as a novel contributor of oxidative metabolism in melanoma cells. Cell Commun Signal. 2018 Nov 22;16(1):87. doi: 10.1186/s12964-018-0297-z. PubMed PMID: 30466459; PubMed Central PMCID: PMC6249961. [IF 7.540]
Andreucci E, Ruzzolini J, Peppicelli S, Bianchini F, Laurenzana A, Carta F, Supuran CT, Calorini L. The carbonic anhydrase IX inhibitor SLC-0111 sensitises cancer cells to conventional chemotherapy. J Enzyme Inhib Med Chem. 2019 Dec;34(1):117-123. doi: 10.1080/14756366.2018.1532419. PubMed PMID: 30362384; PubMed Central PMCID: PMC6211231 [I.F. 5.756]
Maggi V, Bianchini F, Portioli E, Peppicelli S, Lulli M, Bani D, Sole RD, Zanardi F, Sartori A, Fiammengo R. Gold Nanoparticles Functionalized with RGD-Semipeptides: A Simple yet Highly Effective Targeting System for α(V) β(3) Integrins. Chemistry. 2018 Aug 14;24(46):12093-12100. doi: 10.1002/chem.201801823. Epub 2018 Jul 16. PubMed PMID: 29923243. [co-first, IF 5.020]
Sernissi L, Ricci L, Scarpi D, Bianchini F, Arosio D, Contini A, Occhiato EG. Stereodivergent synthesis of 5-aminopipecolic acids and application in the preparation of a cyclic RGD peptidomimetic as a nanomolar α(V)β(3) integrin ligand. Org Biomol Chem. 2018 May 9;16(18):3402-3414. doi: 10.1039/c8ob00534f. PubMed PMID: 29675532. [IF 3.890]
Ricci L, Sernissi L, Scarpi D, Bianchini F, Contini A, Occhiato EG. Synthesis and conformational analysis of peptides embodying 2,3-methanopipecolic acids. Org Biomol Chem. 2017 Aug 16;15(32):6826-6836. doi: 10.1039/c7ob01617d. PubMed PMID: 28782780. [IF 3.890]
Peppicelli S, Andreucci E, Ruzzolini J, Laurenzana A, Margheri F, Fibbi G, Del Rosso M, Bianchini F, Calorini L. The acidic microenvironment as a possible niche of dormant tumor cells. Cell Mol Life Sci. 2017 Aug;74(15):2761-2771. doi: 10.1007/s00018-017-2496-y. [co-corresponding IF 9.234].
Andreucci E, Peppicelli S, Carta F, Brisotto G, Biscontin E, Ruzzolini J, Bianchini F, Biagioni A, Supuran CT, Calorini L. Carbonic anhydrase IX inhibition affects viability of cancer cells adapted to extracellular acidosis. J Mol Med (Berl). 2017 Dec;95(12):1341-1353. doi: 10.1007/s00109-017-1590-9. [I.F. 5.606].
Ruzzolini J, Peppicelli S, Andreucci E, Bianchini F, Margheri F, Laurenzana A, Fibbi G, Pimpinelli N, Calorini L. Everolimus selectively targets vemurafenib resistant BRAF(V600E) melanoma cells adapted to low pH. Cancer Lett. 2017 Nov 1;408: 43-54. doi: 10.1016/j.canlet.2017.08.010. [IF 9.756]
Laurenzana A, Chillà A, Luciani C, Peppicelli S, Biagioni A, Bianchini F, Tenedini E, Torre E, Mocali A, Calorini L, Margheri F, Fibbi G, Del Rosso M. uPA/uPAR system activation drives a glycolytic phenotype in melanoma cells. Int J Cancer. 2017 Sep 15;141(6):1190-1200. doi: 10.1002/ijc.30817 [IF 7.316]
Sartori A, Portioli E, Battistini L, Calorini L, Pupi A, Vacondio F, Arosio D, Bianchini F, Zanardi F. Synthesis of Novel c(AmpRGD)-Sunitinib Dual Conjugates as Molecular Tools Targeting the α(v)β(3) Integrin/VEGFR2 Couple and Impairing Tumor-Associated Angiogenesis. J Med Chem. 2017 Jan 12;60(1):248-262. doi:10.1021/acs.jmedchem .6b01266. PubMed PMID: 27997164. [co-corresponding, I.F. 8.039].
Bianchini F, Peppicelli S, Fabbrizzi P, Biagioni A, Mazzanti B, Menchi G, Calorini L, Pupi A, Trabocchi A. Triazole RGD antagonist reverts TGFβ1-induced endothelial-to-mesenchymal transition in endothelial precursor cells. Mol Cell Biochem. 2017 Jan;424(1-2):99-110. doi: 10.1007/s11010-016-2847-2. PubMed PMID: 27761847; PubMed Central PMCID: PMC5219041. [corresponding IF 3.842]
Margheri G, Zoppi A, Olmi R, Trigari S, Traversi R, Severi M, Bani D, Bianchini F, Torre E, Margheri F, Chillà A, Biagioni A, Calorini L, Laurenzana A, Fibbi G, Del Rosso M. Tumor-tropic endothelial colony forming cells (ECFCs) loaded with near-infrared sensitive Au nanoparticles: A "cellular stove" approach to the photoablation of melanoma. Oncotarget. 2016 Jun 28;7(26):39846-39860. doi: 10.18632/oncotarget.9511. PubMed PMID: 27223433.
Lenci E, Innocenti R, Biagioni A, Menchi G, Bianchini F, Trabocchi, A. Identification of novel human breast carcinoma (MDA-MB-231) Cell growth modulators from a carbohydrate-based diversity-oriented synthesis library. Molecules 2016. 21; 10: 1405. [co-corresponding I.F. 4.927]
Andreucci E, Bianchini F, Biagioni A, Del Rosso M, Papucci L, Schiavone N, Magnelli, L. Roles of different IRES-dependent FGF2 isoforms in the acquisition of the major aggressive features of human metastatic melanoma. Journal of Molecular Medicine J Mol Med (Berl). 2017 Jan;95(1):97-108. doi: 10.1007/s00109-016-1463-7. [I.F. 5.606].
Calvani M, Bianchini F, Taddei ML, Becatti M, Giannoni E, Chiarugi P, Calorini L. Etoposide-Bevacizumab a new strategy against human melanoma cells expressing stem-like traits. Oncotarget. 2016; 7:51138-51149. doi: 10.18632/oncotarget.9939. PubMed PMID: 27303923.
Sernissi L, Trabocchi A, Scarpi D, Bianchini F, Occhiato EG. Cyclic RGD peptidomimetics containing 4- and 5-amino-cyclopropane pipecolic acid (CPA) templates as dual αvβ3 and α5β1integrin ligands. Bioorganic and Medicinal Chemistry, 2016: 24 (4): 703-711. [IF 2.940]
Peppicelli S, Toti A, Giannoni E, Bianchini F, Margheri F, Del Rosso M, Calorini L. Metformin is also effective on lactic acidosis-exposed melanoma cells switched to oxidative phosphorylation. Cell Cycle. 2016 Jul 17;15(14):1908-18. doi: 10.1080/15384101.2016.1191706. PubMed PMID: 27266957; PubMed Central PMCID: PMC4968910. [IF 5.173]
Peppicelli S, Bianchini F, Toti A, Laurenzana A, Fibbi G, Calorini L. Extracellular acidity strengthens mesenchymal stem cells to promote melanoma progression. Cell Cycle. 2015;14(19):3088-100. doi: 10.1080/15384101.2015.1078032. PubMed PMID: 26496168; PubMed Central PMCID: PMC4825622. [IF 5.173]
Sartori A, Bianchini F, Migliari S, Burreddu P, Curti C, Vacondio F, Arosio D Ruffini L, Rassu G, Calorini L, Pupi A, Zanardi F, Battistini L. Synthesis and preclinical evaluation of a novel, selective ¹¹¹In-labelled aminoproline-RGD-peptide for non-invasive melanoma tumor imaging. MedChemComm. 2015; 6 (2): 2175-2183. [IF 5.121]
Peppicelli S, Bianchini F, Calorini L. Metabolic reprogramming as a continuous changing behavior of tumor cells. Tumor Biol. 2015 Aug;36(8):5759-62. doi: 10.1007/s13277-015-3762-y. PubMed PMID: 26159855. [IF 3.650]
Peppicelli S, Bianchini F, Calorini L. Dynamic scenario of metabolic pathway adaptation in tumors and therapeutic approach. Oncoscience. 2015 Feb 9;2(3):225-32. PubMed PMID: 25897425; PubMed Central PMCID: PMC4394127.
Laurenzana A, Biagioni A, Bianchini F, Peppicelli S, Chillà A, Margheri F, Luciani C, Pimpinelli N, Del Rosso M, Calorini L, Fibbi G. Inhibition of uPAR-TGFβ crosstalk blocks MSC-dependent EMT in melanoma cells. J Mol Med (Berl). 2015 Jul;93(7):783-94. doi: 10.1007/s00109-015-1266-2. PubMed PMID: 25694039. [I.F. 5.606].
Laurenzana A, Cencetti F, Serratì S, Bruno G, Japtok L, Bianchini F, Torre E, Fibbi G, Del Rosso M, Bruni P, Donati C. Endothelial sphingosine kinase/SPNS2 axis is critical for vessel-like formation by human mesoangioblasts. Journal of Molecular Medicine, 2015: 93 (10): 1145-1157[I.F. 5.606].
Bianchini F, Fabbrizzi P, Menchi G, Raspanti S, Bottoncetti A, Passeri A, Andreucci E, Guarna A, Calorini L, Pupi A, Trabocchi A. Radiosynthesis and micro-SPECT analysis of triazole-based RGD integrin ligands as non-peptide molecular imaging probes for angiogenesis. Bioorg Med Chem. 2015 Mar 1;23(5):1112-22. doi: 10.1016/j.bmc.2014.12.065. PubMed PMID: 25637121. [first IF 3.641]
Giannoni E, Taddei ML, Morandi A, Comito G, Calvani M, Bianchini F, Richichi B, Raugei G, Wong N, Tang D, Chiarugi P. Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread. Oncotarget. 2015 Sep 15;6(27):24061-74. PubMed PMID: 26183399;
Rovida E, Peppicelli S, Bono S, Bianchini F, Tusa I, Cheloni G, Marzi I, Cipolleschi MG, Calorini L, Sbarba PD. The metabolically-modulated stem cell niche: a dynamic scenario regulating cancer cell phenotype and resistance to therapy. Cell Cycle. 2014;13(20):3169-75. doi: 10.4161/15384101.2014.964107. PubMed PMID: 25485495; PubMed Central PMCID: PMC4612663. [IF 5.173]
Peppicelli S, Bianchini F, Calorini L. Inflammatory cytokines induce vascular endothelial growth factor-C expression in melanoma-associated macrophages and stimulate melanoma lymph node metastasis. Oncol Lett. 2014 Sep;8(3):1133-1138. PubMed PMID: 25120672; PubMed Central PMCID: PMC4114605. [IF 3.111]
Bianchini F, Calugi C, Ruzzolini J, Menchi G, Calorini L, Guarna A, Trabocchi A Study of a D-proline peptidomimetic inhibitor of melanoma and endothelial cells invasion through activity towards MMP-2 and MMP-9. Med Chem Comm 2014;DOI 10.1039/C4MD00287C. [first and co-corresponding IF 5.121]
Fabbrizzi, P Bianchini F, Menchi G, Raspanti S, Guarna A, Trabocchi A. Combination of click chemistry and sulfonamides to develop three-armed triazole compoundsTETRAHEDRON 2014; 70: 5439–5449. DOI: 10.1016/j.tet.2014.06.125 [IF 2.388]
Laurenzana A, Biagioni A, D'Alessio S, Bianchini F, Chillà A, Margheri F, Luciani C, Mazzanti B, Pimpinelli N, Torre E, Danese S, Calorini L, Del Rosso M, Fibbi G. Melanoma cell therapy: Endothelial progenitor cells as shuttle of the MMP12 uPAR-degrading enzyme. Oncotarget. 2014 Jun 15;5(11):3711-27. PubMed PMID: 25003596; PubMed Central PMCID: PMC4116515.
Sernissi L, Petrović M, Scarpi D, Guarna A, Trabocchi A, Bianchini F, Occhiato EG. Cyclopropane pipecolic acids as templates for linear and cyclic peptidomimetics: application in the synthesis of an Arg-Gly-Asp (RGD)-containing peptide as an αvβ3 integrin ligand. Chemistry. 2014 Aug 25;20(35):11187-203. doi: 10.1002/chem.201403077. Epub 2014 Jul 28. PubMed PMID: 25069617. [, IF 5.020]
Peppicelli S, Bianchini F, Calorini L. Extracellular acidity, a "reappreciated" trait of tumor environment driving malignancy: perspectives in diagnosis and therapy. Cancer Metastasis Rev. 2014 Sep;33(2-3):823-32. doi: 10.1007/s10555-014-9506-4. PubMed PMID: 24984804. [IF 9.237]
Parri M, Pietrovito L, Grandi A, Campagnoli S, De Camilli E, Bianchini F, Marchiò S, Bussolino F, Jin B, Sarmientos P, Grandi G, Viale G, Pileri P, Chiarugi P, Grifantini R. Angiopoietin-like 7, a novel pro-angiogenetic factor over-expressed in cancer. Angiogenesis. 2014 Oct;17(4):881-96. doi: 10.1007/s10456-014-9435-4. Epub 2014 Jun 6. PubMed PMID: 24903490. [IF. 10.650]
Giusti B, Margheri F, Rossi L, Lapini I, Magi A, Serratì S, Chillà A, Laurenzana A, Magnelli L, Calorini L, Bianchini F, Fibbi G, Abbate R, Del Rosso M. Desmoglein-2-integrin Beta-8 interaction regulates actin assembly in endothelial cells: deregulation in systemic sclerosis. PLoS One. 2013 Jul 11;8(7): e68117. doi: 10.1371/journal.pone.0068117. [IF 3.752]
Peppicelli S, Bianchini F, Torre E., Calorini L Contribution of acidic melanoma cells undergoing epithelial-to-mesenchymal transition to aggressiveness of non-acidic melanoma cells. Clin. & Exp. Metastasis 2014 Apr;31(4):423-33. doi: 10.1007/s10585-014-9637-6. [IF 4.510]
Marconi C, Peppicelli S, Bianchini F, Calorini L. TNFα receptor1 drives hypoxia-promoted invasiveness of human melanoma cells. Exp Oncol. 2013 Sep;35(3):187-91. PubMed PMID: 24084456.
Peppicelli S, Bianchini F, Contena C, Tombaccini D, Calorini L. Acidic pH via NF-κB favours VEGF-C expression in human melanoma cells. Clin Exp Metastasis. 2013 Dec;30(8):957-67. doi: 10.1007/s10585-013-9595-4. [IF 4.510]
Margheri F, Schiavone N, Papucci L, Magnelli L, Serratì S, Chillà A, Laurenzana A, Bianchini F, Calorini L, Torre E, Dotor J, Feijoo E, Fibbi G, Del Rosso M. GDF5 regulates TGFß-dependent angiogenesis in breast carcinoma MCF-7 cells: in vitro and in vivo control by anti-TGFß peptides. PLoS One. 2012;7(11):e50342. doi: 10.1371/journal.pone.0050342. Epub 2012 Nov 30. PubMed PMID: 23226264; PubMed Central PMCID: PMC3511424. [IF 3.752]
Calorini L, Peppicelli S, Bianchini F. Extracellular acidity as favouring factor of tumor progression and metastatic dissemination. Exp Oncol. 2012 Jul;34(2):79-84. Review. PubMed PMID: 23013757. [IF 0.752]
Giannoni E, Taddei ML, Parri M, Bianchini F, Santosuosso M, Grifantini R, Fibbi G, Mazzanti B, Calorini L, Chiarugi P. EphA2-mediated mesenchymal-amoeboid transition induced by endothelial progenitor cells enhances metastatic spread due to cancer-associated fibroblasts. J Mol Med (Berl). 2013 Jan;91(1):103-15. doi: 10.1007/s00109-012-0941-9. Epub 2012 Aug 19. PubMed PMID: 22903544[I.F. 5.606].
Femia AP, Luceri C, Bianchini F, Salvadori M, Salvianti F, Pinzani P, Dolara P, Calorini L, Caderni G. Marie Ménard apples with high polyphenol content and a low-fat diet reduce 1,2-dimethylhydrazine-induced colon carcinogenesis in rats: effects on inflammation and apoptosis. Mol Nutr Food Res. 2012 Aug;56(8):1353-7. doi: 10.1002/mnfr.201200122. Epub 2012 Jun 20. PubMed PMID: 22715065. [IF 6.575]
Bianchini F, Cini N, Trabocchi A, Bottoncetti A, Raspanti S, Vanzi E, Menchi G, Guarna A, Pupi A, Calorini L. ¹²⁵I-radiolabeled morpholine-containing arginine-glycine-aspartate (RGD) ligand of αvβ₃ integrin as a molecular imaging probe for an agiogenesis. J Med Chem. 2012 Jun 14;55(11):5024-33. doi: 10.1021/jm2016232. Epub 2012 Jun 1. PubMed PMID: 22621422. [first, I.F. 8.039].
Bianchini F, Giannoni E, Serni S, Chiarugi P, Calorini L. 22: 6n-3 DHA inhibits differentiation of prostate fibroblasts into myofibroblasts and tumorigenesis. Br J Nutr. 2012 Dec 28;108(12):2129-37. doi: 10.1017/S0007114512000359. Epub 2012 Mar 6. PubMed PMID: 22390897. [first, IF 4.125]
Margheri F, Chillà A, Laurenzana A, Serratì S, Mazzanti B, Saccardi R, Santosuosso M, Danza G, Sturli N, Rosati F, Magnelli L, Papucci L, Calorini L, Bianchini F, Del Rosso M, Fibbi G. Endothelial progenitor cell-dependent angiogenesis requires localization of the full-length form of uPAR in caveolae. Blood. 2011 Sep 29;118(13):3743-55. doi: 10.1182/blood-2011-02-338681. Epub 2011 Jul 29. PubMed PMID: 21803847. [IF 25.669]
Comito G, Calvani M, Giannoni E, Bianchini F, Calorini L, Torre E, Migliore C, Giordano S, Chiarugi P. HIF-1α stabilization by mitochondrial ROS promotes Met-dependent invasive growth and vasculogenic mimicry in melanoma cells. Free Radic Biol Med. 2011 Aug 15;51(4):893-904. doi: 10.1016/j.freeradbiomed.2011.05.042. Epub 2011 Jun 12. PubMed PMID: 21703345. [IF 8.101]
Giannoni E, Bianchini F, Calorini L, Chiarugi P. Cancer associated fibroblasts exploit reactive oxygen species through a proinflammatory signature leading to epithelial mesenchymal transition and stemness. Antioxid Redox Signal. 2011 Jun 15;14(12):2361-71. doi: 10.1089/ars.2010.3727. Epub 2011 Mar 28. PubMed PMID: 21235356. [IF 7.468]
Taddei ML, Parri M, Angelucci A, Bianchini F, Marconi C, Giannoni E, Raugei G, Bologna M, Calorini L, Chiarugi P. EphA2 induces metastatic growth regulating amoeboid motility and clonogenic potential in prostate carcinoma cells. Mol Cancer Res. 2011 Feb;9(2):149-60. doi: 10.1158/1541-7786.MCR-10-0298. Epub 2011 Jan 4. PubMed PMID: 21205836. [IF 6.333]
Calorini L, Bianchini F. Environmental control of invasiveness and metastatic dissemination of tumor cells: the role of tumor cell-host cell interactions. Cell Commun Signal. 2010 Sep 7;8:24. doi: 10.1186/1478-811X-8-24. PubMed PMID: 20822533; PubMed Central PMCID: PMC2945354. [IF 7.540]
Trabocchi A, Menchi G, Cini N, Bianchini F, Raspanti S, Bottoncetti A, Pupi A, Calorini L, Guarna A. Click-chemistry-derived triazole ligands of arginine-glycine-aspartate (RGD) integrins with a broad capacity to inhibit adhesion of melanoma cells and both in vitro and in vivo angiogenesis. J Med Chem. 2010 Oct 14;53(19):7119-28. doi: 10.1021/jm100754z. PubMed PMID: 20809642[I.F. 8.039].
Giannoni E, Bianchini F, Masieri L, Serni S, Torre E, Calorini L, Chiarugi P. Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness. Cancer Res. 2010 Sep 1;70(17):6945-56. doi: 10.1158/0008-5472.CAN-10-0785. Epub 2010 Aug 10. PubMed PMID: 20699369. [IF 13.312]
Margheri F, Serratì S, Lapucci A, Chillà A, Bazzichi L, Bombardieri S, Kahaleh B, Calorini L, Bianchini F, Fibbi G, Del Rosso M. Modulation of the angiogenic phenotype of normal and systemic sclerosis endothelial cells by gain-loss of function of pentraxin 3 and matrix metalloproteinase 12. Arthritis Rheum. 2010 Aug;62(8):2488-98. doi: 10.1002/art.27522. PubMed PMID: 20506099. [IF 8.955]
Margheri F, Serratì S, Lapucci A, Anastasia C, Giusti B, Pucci M, Torre E, Bianchini F, Calorini L, Albini A, Ventura A, Fibbi G, Del Rosso M. Systemic sclerosis-endothelial cell antiangiogenic pentraxin 3 and matrix metalloprotease 12 control human breast cancer tumor vascularization and development in mice. Neoplasia. 2009 Oct;11(10):1106-15. PubMed PMID: 19794969; PubMed Central PMCID: PMC2745676. [IF 6.218]
Taddei ML, Parri M, Angelucci A, Onnis B, Bianchini F, Giannoni E, Raugei G, Calorini L, Rucci N, Teti A, Bologna M, Chiarugi P. Kinase-dependent and -independent roles of EphA2 in the regulation of prostate cancer invasion and metastasis. Am J Pathol. 2009 Apr;174(4):1492-503. doi: 10.2353/ajpath.2009.080473. Epub 2009 Mar 5. PubMed PMID: 19264906; PubMed Central PMCID: PMC2671379. [IF 5.770]
Parri M, Taddei ML, Bianchini F, Calorini L, Chiarugi P. EphA2 reexpression prompts invasion of melanoma cells shifting from mesenchymal to amoeboid-like motility style. Cancer Res. 2009 Mar 1;69(5):2072-81. doi: 10.1158/0008-5472.CAN-08-1845. Epub 2009 Feb 24. PubMed PMID: 19244130. [IF 13.312]
Marconi C, Bianchini F, Mannini A, Mugnai G, Ruggieri S, Calorini L. Tumoral and macrophage uPAR and MMP-9 contribute to the invasiveness of B16 murine melanoma cells. Clin Exp Metastasis. 2008;25(3):225-31. Epub 2007 Dec 11. PubMed PMID: 18071911. [IF 4.510]
Massi D, Marconi C, Franchi A, Bianchini F, Paglierani M, Ketabchi S, Miracco C, Santucci M, Calorini L. Arginine metabolism in tumor-associated macrophages in cutaneous malignant melanoma: evidence from human and experimental tumors. Hum Pathol. 2007 Oct;38(10):1516-25 Epub 2007 Jul 19. PubMed PMID: 17640716. [IF 3.526].
Bianchini F, Massi D, Marconi C, Franchi A, Baroni G, Santucci M, Mannini A, Mugnai G, Calorini L. Expression of cyclo-oxygenase-2 in macrophages associated with cutaneous melanoma at different stages of progression. Prostaglandins Other Lipid Mediat. 2007 Jun;83(4):320-8. Epub 2007 Mar 13. PubMed PMID: 17499752. [first, IF 3.813]
Bianchini F, Mannini A, Mugnai G, Ruggieri S, Calorini L. Expression of a metastatic phenotype in IFNs-primed/TNFalpha-activated B16 murine melanoma cells: role of JAK1/PKCdelta signal transduction factors. Clin Exp Metastasis. 2006;23(3-4):203-8. Epub 2006 Sep 22. PubMed PMID: 17028922. [first, [IF 4.510]
Bianchini F, D'Alessio S, Fibbi G, Del Rosso M, Calorini L. Cytokine-dependent invasiveness in B16 murine melanoma cells: role of uPA system and MMP-9. Oncol Rep. 2006 Mar;15(3):709-14. PubMed PMID: 16465434. [first, IF 4.136]
Arita M, Bianchini F, Aliberti J, Sher A, Chiang N, Hong S, Yang R, Petasis NA, Serhan CN. Stereochemical Assignment, Anti-Inflammatory Properties, and Receptor for the Omega-3 Lipid Mediator Resolvin E1. J Exp Med. 2005 Mar 7;201(5):713-22. [IF 17.579]
Calorini L, Bianchini F, Mannini A, Mugnai G, Ruggieri S. Enhancement of nitric oxide release in mouse inflammatory macrophages co-cultivated with tumor cells of a different origin. Clin Exp Metastasis. 2005;22(5):413-9. PubMed PMID: 16283484. [IF 4.510]
Calorini L, Bianchini F, Mannini A, Mugnai G, Ruggieri S. Inhibition of lipoxygenase pathway in macrophages co-cultivated with tumor cells. Cancer Lett. 2005 Jun 1;223(1):151-8. Epub 2004 Nov 2. PubMed PMID: 15890248. [IF 9.756]
Bertini I, Bianchini F, Calorini L, Colagrande S, Fragai M, Franchi A, Gallo O, Gavazzi C, Luchinat C. Persistent contrast enhancement by sterically stabilized paramagnetic liposomes in murine melanoma. Magn Reson Med. 2004 Sep;52(3):669-72. PubMed PMID: 15334589. [IF 3.737]
Calorini L, Bianchini F, Mannini A, Mugnai G, Balzi M, Becciolini A, Ruggieri S. IFNgamma and TNFalpha account for a pro-clonogenic activity secreted by activated murine peritoneal macrophages. Clin Exp Metastasis. 2002;19(3):259-64. PubMed PMID: 12067206. IF 4.510]
Calorini L, Mannini A, Bianchini F, Mugnai G, Balzi M, Becciolini A, Ruggieri S. Biological properties associated with the enhanced lung-colonizing potential in a B16 murine melanoma line grown in a medium conditioned by syngeneic Corynebacterium parvum-elicited macrophages. Clin Exp Metastasis. 1999;17(10):889-95. PubMed PMID: 11089888. [IF 4.510]
Calorini L, Mannini A, Bianchini F, Mugnai G, Ruggieri S. The change in leukotrienes and lipoxins in activated mouse peritoneal macrophages. Biochim Biophys Acta - Molecular and Cell Biology of Lipids. 2000 Apr 12;1484(2-3):87-92. PubMed PMID: 10760459. [IF 5.228].

Francesca BIANCHINI

Pubblicazioni

Legenda

Contributo su rivista |

Articolo su libro |

Libro |

Contributo in atti di convegno (proceeding) |

Brevetto |

Curatela | Altro

Altro |

Tesi di Dottorato

Andreucci, Elena; Biagioni, Alessio; Peri, Sara; Versienti, Giampaolo; Cianchi, Fabio; Staderini, Fabio; Antonuzzo, Lorenzo; Supuran, Claudiu T; Olivo, Erika; Pasqualini, Elisa; Messerini, Luca; Massi, Daniela; Lulli, Matteo; Ruzzolini, Jessica; Peppicelli, Silvia; Bianchini, Francesca; Schiavone, Nicola; Calorini, Lido; Magnelli, Lucia; Papucci, Laura (2023). The CAIX inhibitor SLC-0111 exerts anti-cancer activity on gastric cancer cell lines and resensitizes resistant cells to 5-Fluorouracil, taxane-derived, and platinum-based drugs. CANCER LETTERS, vol. 571, pp. 1-12, ISSN:0304-3835 DOI

Andreucci, Elena; Bugatti, Kelly; Peppicelli, Silvia; Ruzzolini, Jessica; Lulli, Matteo; Calorini, Lido; Battistini, Lucia; Zanardi, Franca; Sartori, Andrea; Bianchini, Francesca (2023). Nintedanib-αVβ6 Integrin Ligand Conjugates Reduce TGFβ-Induced EMT in Human Non-Small Cell Lung Cancer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 24, pp. 0-0, ISSN:1422-0067 DOI

Landini, Lorenzo; Marini, Matilde; Souza Monteiro de Araujo, Daniel; Romitelli, Antonia; Montini, Marco; Albanese, Valentina; Titiz, Mustafa; Innocenti, Alessandro; Bianchini, Francesca; Geppetti, Pierangelo; Nassini, Romina; De Logu, Francesco (2023). Schwann cell insulin-like growth factor receptor type-1 mediates metastatic bone cancer pain in mice. BRAIN, BEHAVIOR, AND IMMUNITY, vol. 110, pp. 348-364, ISSN:1090-2139 DOI

Elena Andreucci, Jessica Ruzzolini, Francesca Bianchini, Giampaolo Versienti, Alessio Biagioni, Matteo Lulli, Daniele Guasti, Patrizia Nardini, Simona Serratì, Francesca Margheri, Anna Laurenzana, Chiara Nediani, Silvia Peppicelli, Lido Calorini (2022). miR-214-enriched extracellular vesicles released by acid-adapted melanoma cells promote inflammatory macrophage-dependent tumor trans-endothelial migration. CANCERS, vol. 14, pp. 0-0, ISSN:2072-6694 DOI

Sara Peri, Jessica Ruzzolini, Silvia Urciuoli, Giampaolo Versienti, Alessio Biagioni, Elena Andreucci, Silvia Peppicelli, Francesca Bianchini, Andrea Bottari, Lido Calorini, Chiara Nediani, Lucia Magnelli, Laura Papucci (2022). An Oleocanthal-Enriched EVO Oil Extract Induces the ROS Production in Gastric Cancer Cells and Potentiates the Effect of Chemotherapy. ANTIOXIDANTS, vol. 11, pp. 1762-1784, ISSN:2076-3921 DOI

Sofia Chioccioli; Jessica Ruzzolini; Silvia Urciuoli; Gian Luca Bartolucci; Marco Pallecchi; Lido Calorini; Carlotta De Filippo; Francesco Vitali; Chiara Nediani; Francesca Bianchini; Giovanna Caderni (2022). Oleuropein-rich leaf extract affects intestinal microbiota and free fatty acids in Apc-mutant and wt rats. In: 7th MS-Food, Florence (Italy), 5-7 October 2022, Scientific Committee of 7th MS-Food, 5-7 October 2022, Florence (Italy), pp. 68-69.

Calugi L.; Lenci E.; Bianchini F.; Contini A.; Trabocchi A. (2022). Modular synthesis of 2,4-diaminoanilines as CNS drug-like non-covalent inhibitors of asparagine endopeptidase. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 63, pp. 116746-116746, ISSN:0968-0896 DOI Accesso ONLINE all'editore

Kelly Bugatti , Elena Andreucci, Noemi Monaco, Lucia Battistini, Silvia Peppicelli, Jessica Ruzzolini, Claudio Curti, Franca Zanardi, Francesca Bianchini, Andrea Sartori (2022). Nintedanib-Containing Dual Conjugates Targeting αVβ6 Integrin and Tyrosine Kinase Receptors as Potential Antifibrotic Agents. ACS OMEGA, vol. 7, pp. 17658-17669, ISSN:2470-1343 DOI Accesso ONLINE all'editore

Elena Andreucci, Silvia Peppicelli, Jessica Ruzzolini, Francesca Bianchini, Lido Calorini (2022). Physicochemical aspects of the tumour microenvironment as drivers of vasculogenic mimicry. CANCER AND METASTASIS REVIEWS, vol. ..., pp. 0-0, ISSN:1573-7233 DOI

Innocenti R.; Dallari C.; Lenci E.; Pavone F.S.; Bianchini F.; Credi C.; Trabocchi A. (2022). Design, synthesis and evaluation of RGD peptidomimetic – Gold nanostar conjugates as M21 cell adhesion inhibitors. BIOORGANIC CHEMISTRY, vol. 126, pp. 105873-105873, ISSN:0045-2068 DOI Accesso ONLINE all'editore

Peppicelli, Silvia; Ruzzolini, Jessica; Lulli, Matteo; Biagioni, Alessio; Bianchini, Francesca; Caldarella, Adele; Nediani, Chiara; Andreucci, Elena; Calorini, Lido (2022). Extracellular Acidosis Differentially Regulates Estrogen Receptor β-Dependent EMT Reprogramming in Female and Male Melanoma Cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, pp. 0-0, ISSN:1422-0067 DOI

Ippolito, Luigi; Comito, Giuseppina; Parri, Matteo; Iozzo, Marta; Duatti, Assia; Virgilio, Francesca; Lorito, Nicla; Bacci, Marina; Pardella, Elisa; Sandrini, Giada; Bianchini, Francesca; Damiano, Roberta; Ferrone, Lavinia; la Marca, Giancarlo; Serni, Sergio; Spatafora, Pietro; Catapano, Carlo V; Morandi, Andrea; Giannoni, Elisa; Chiarugi, Paola (2022). Lactate rewires lipid metabolism and sustains a metabolic-epigenetic axis in prostate cancer. CANCER RESEARCH, pp. canres.0914.2021-canres.0914.2021, ISSN:0008-5472 DOI

T Chatzisideri, G. Leonidis, T. Karampelas, E. Skavatsou, A. Velentza-Almpani, F Bianchini, C Tamvakopoulos*, and Vasiliki Sarli* (2022). Integrin-Mediated Targeted Cancer Therapy Using c(RGDyK)-Based Conjugates of Gemcitabine. JOURNAL OF MEDICINAL CHEMISTRY, vol. 65, pp. 271-284, ISSN:0022-2623 DOI

Baldini, Lorenzo; Lenci, Elena; Bianchini, Francesca; Trabocchi, Andrea (2022). Identification of a Common Pharmacophore for Binding to MMP2 and RGD Integrin: Towards a Multitarget Approach to Inhibit Cancer Angiogenesis and Metastasis. MOLECULES, vol. 27, pp. 0-0, ISSN:1420-3049 DOI Accesso ONLINE all'editore

Jessica Ruzzolini , Sofia Chioccioli , Noemi Monaco , Silvia Peppicelli , Elena Andreucci , Silvia Urciuoli , Annalisa Romani, Cristina Luceri , Katia Tortora , Lido Calorini , Giovanna Caderni , Chiara Nediani , Francesca Bianchini (2021). Oleuropein-rich leaf extract as a broad inhibitor of tumour and macrophage iNOS in an apc mutant rat model. ANTIOXIDANTS, vol. 10, pp. 0-0, ISSN:2076-3921 DOI

Andreucci E, Laurenzana A, Peppicelli S, Biagioni A, Margheri F, Ruzzolini J, Bianchini F, Fibbi G, Del Rosso M, Nediani C, Serratì S, Fucci L, Guida M, Calorini L. (2021). uPAR controls vasculogenic mimicry ability expressed by drug-resistant melanoma cells.. ONCOLOGY RESEARCH, vol. 28, pp. 873-884, ISSN:1555-3906 DOI

Andreucci, Elena; Margheri, Francesca; Peppicelli, Silvia; Bianchini, Francesca; Ruzzolini, Jessica; Laurenzana, Anna; Fibbi, Gabriella; Bruni, Cosimo; Bellando-Randone, Silvia; Guiducci, Serena; Romano, Eloisa; Manetti, Mirko; Matucci-Cerinic, Marco; Calorini, Lido (2021). Glycolysis-derived acidic microenvironment as a driver of endothelial dysfunction in systemic sclerosis. RHEUMATOLOGY, vol. 60, pp. 4508-4519, ISSN:1462-0324 DOI

Chatzisideri T.,Dalezis P.,Leonidis G., Bousis S., Trafalis D., Bianchini F., Sarli V. (2021). Synthesis and biological studies of c(RGDyK) conjugates of cucurbitacins. FUTURE MEDICINAL CHEMISTRY, vol. 13, pp. 877-895, ISSN:1756-8919 DOI

Sartori A.; Bugatti K.; Portioli E.; Baiula M.; Casamassima I.; Bruno A.; Bianchini F.; Curti C.; Zanardi F.; Battistini L. (2021). New 4-aminoproline-based small molecule cyclopeptidomimetics as potential modulators of α4β1 integrin. MOLECULES, vol. 26, pp. 6066-6087, ISSN:1420-3049 DOI

Alessio Biagioni, Anastasia Chillà, Mario Del Rosso, Gabriella Fibbi, Francesca Scavone, Elena Andreucci, Silvia Peppicelli, Francesca Bianchini, Lido Calorini, Anna Li Santi, Pia Ragno, Francesca Margheri, Anna Laurenzana (2021). CRISPR/Cas9 uPAR Gene Knockout Results in Tumor Growth Inhibition, EGFR Downregulation and Induction of Stemness Markers in Melanoma and Colon Carcinoma Cell Lines. FRONTIERS IN ONCOLOGY, pp. 1-13, ISSN:2234-943X DOI

Calvani M.; Bruno G.; Dabraio A.; Subbiani A.; Bianchini F.; Fontani F.; Casazza G.; Vignoli M.; De Logu F.; Frenos S.; Filippi L.; Favre C. (2020). β3-Adrenoreceptor Blockade Induces Stem Cells Differentiation in Melanoma Microenvironment. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, pp. 0-0, ISSN:1661-6596 DOI

Jessica Ruzzolini , Silvia Peppicelli , Francesca Bianchini , Elena Andreucci , Silvia Urciuoli , Annalisa Romani , Katia Tortora , Giovanna Caderni , Chiara Nediani ,Lido Calorini (2020). Cancer glycolytic dependence as an new target of olive leaf extract. CANCERS, vol. 12, pp. 0-0, ISSN:2072-6694 DOI

Ruzzolini J, Laurenzana A, Andreucci E, Peppicelli S, Bianchini F, Carta F, Supuran CT, Romanelli MN, Nediani C, Calorini L. (2020). A potentiated cooperation of carbonic anhydrase IX and histone deacetylase inhibitors against cancer. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 391-397, ISSN:1475-6366 DOI

Elena Andreucci, Silvia Peppicelli, Jessica Ruzzolini, Francesca Bianchini, Alessio Biagioni, Laura Papucci, Lucia Magnelli, Benedetta Mazzanti, Barbara Stecca, Lido Calorini (2020). The acidic tumor microenvironment drives a stem-like phenotype in melanoma cells. JOURNAL OF MOLECULAR MEDICINE, vol. 98, pp. 1431-1446, ISSN:0946-2716 DOI

Dordoni F.; Scarpi D.; Bianchini F.; Contini A.; Occhiato E.G. (2020). Enantioselective Synthesis of cis and trans 4-Aminopipecolic Acids as γ-Amino Acids for the Construction of Cyclic RGD-Containing Peptidomimetics Antagonists of αVβ3 Integrin. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2020, pp. 4371-4383, ISSN:1434-193X DOI

Margheri F.; Maggi L.; Biagioni A.; Chilla A.; Laurenzana A.; Bianchini F.; Bani D.; Capone M.; Mazzoni A.; Rossi M.C.; Liotta F.; Cosmi L.; Giani T.; Cimaz R.; Fibbi G.; Annunziato F.; Rosso M.D. (2020). Th17 lymphocyte-dependent degradation of joint cartilage by synovial fibroblasts in a humanized mouse model of arthritis and reversal by secukinumab. EUROPEAN JOURNAL OF IMMUNOLOGY, pp. 0-0, ISSN:0014-2980 DOI

Biagioni A.; Laurenzana A.; Menicacci B.; Peppicelli S.; Andreucci E.; Bianchini F.; Guasti D.; Paoli P.; Serrati S.; Mocali A.; Calorini L.; Del Rosso M.; Fibbi G.; Chilla A.; Margheri F. (2020). uPAR-expressing melanoma exosomes promote angiogenesis by VE-Cadherin, EGFR and uPAR overexpression and rise of ERK1,2 signaling in endothelial cells. CELLULAR AND MOLECULAR LIFE SCIENCES, pp. 1-20, ISSN:1420-682X DOI

Armanetti P.; Chilla A.; Margheri F.; Biagioni A.; Menichetti L.; Margheri G.; Ratto F.; Centi S.; Bianchini F.; Severi M.; Traversi R.; Bani D.; Lulli M.; Del Rosso T.; Mocali A.; Rovida E.; Del Rosso M.; Fibbi G.; Laurenzana A. (2020). Enhanced Antitumoral Activity and Photoacoustic Imaging Properties of AuNP-Enriched Endothelial Colony Forming Cells on Melanoma. ADVANCED SCIENCE, pp. 2001175-2001190, ISSN:2198-3844 DOI

Silvia Peppicelli, Elena Andreucci, Jessica Ruzzolini, Francesca Bianchini, Lido Calorini (2020). FDG uptake in cancer: a continuing debate. THERANOSTICS, vol. 10, pp. 2944-2948, ISSN:1838-7640

Silvia Peppicelli, Elena Andreucci, Jessica Ruzzolini, Francesca Bianchini, Chiara Nediani, Claudiu T. Supuran, Lido Calorini (2020). The Carbonic Anhydrase IX inhibitor SLC-0111 as emerging agent against the mesenchymal stem cell-derived pro-survival effects on melanoma cells. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 1185-1193, ISSN:1475-6366 DOI

Andreucci, Elena; Ruzzolini, Jessica; Peppicelli, Silvia; Bianchini, Francesca; Laurenzana, Anna; Carta, Fabrizio; Supuran, Claudiu T.; Calorini, Lido (2019). The carbonic anhydrase IX inhibitor SLC-0111 sensitises cancer cells to conventional chemotherapy. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 34, pp. 117-123, ISSN:1475-6366 DOI Accesso ONLINE all'editore

Silvia Peppicelli, Jessica Ruzzolini, Francesca Bianchini , Elena Andreucci, Chiara Nediani , Anna Laurenzana, Francesca Margheri,Gabriella Fibbi, Lido Calorini (2019). Anoikis resistance as a further trait of acidic-adapted melanoma cells. JOURNAL OF ONCOLOGY, vol. Article ID 8340926, pp. 0-0, ISSN:1687-8469

Bianchini, Francesca*; Portioli, Elisabetta; Ferlenghi, Francesca; Vacondio, Federica; Andreucci, Elena; Biagioni, Alessio; Ruzzolini, Jessica; Peppicelli, Silvia; Lulli, Matteo; Calorini, Lido; Battistini, Lucia; Zanardi, Franca; Sartori, Andrea (2019). Cell-targeted c(AmpRGD)-sunitinib molecular conjugates impair tumor growth of melanoma. CANCER LETTERS, vol. 446, pp. 25-37, ISSN:0304-3835 DOI Accesso ONLINE all'editore

Ruzzolini Jessica, Peppicelli Silvia, Andreucci Elena, Bianchini Francesca, Urciuoli Silvia, Romani Annalisa, Nediani Chiara, Calorini Lido (2019). Oleuropein-enriched olive leaf extract affects BRAF melanoma cells metabolism. In: Polyphenols Applications, International Society of Antioxidants, pp. 109-109.

Francesca Bianchini , Augusta De Santis 2 , Elisabetta Portioli 3 , Irene Russo Krauss 2 , Lucia Battistini 3 , Claudio Curti 3 , Silvia Peppicelli , Lido Calorini , Gerardino D'Errico 2 , Franca Zanardi 4 , Andrea Sartori 5 (2019). Integrin-targeted AmpRGD sunitinib liposomes as integrated antiangiogenic tools.. NANOMEDICINE, pp. 135-145, ISSN:1549-9634 DOI

Bacci M.; Lorito N.; Ippolito L.; Ramazzotti M.; Luti S.; Romagnoli S.; Parri M.; Bianchini F.; Cappellesso F.; Virga F.; Gao Q.; Simoes B.M.; Marangoni E.; Martin L.-A.; Comito G.; Ferracin M.; Giannoni E.; Mazzone M.; Chiarugi P.; Morandi A. (2019). Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer. CELL REPORTS, vol. 28, pp. 104-118.e8, ISSN:2211-1247 DOI Accesso ONLINE all'editore

Lenci E.; Innocenti R.; Di Francescantonio T.; Menchi G.; Bianchini F.; Contini A.; Trabocchi A. (2019). Identification of highly potent and selective MMP2 inhibitors addressing the S1′ subsite with D-proline-based compounds. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 27, pp. 1891-1902, ISSN:0968-0896 DOI Accesso ONLINE all'editore

Peppicelli S, Ruzzolini J, Andreucci E, Bianchini F, Kontos F, Yamada T, Ferrone S, Calorini L (2019). Potential Role of HLA Class I Antigens in the Glycolytic Metabolism and Motility of Melanoma Cells. CANCERS, vol. 11, pp. 0-0, ISSN:2072-6694 DOI

Calvani, Maura; Bruno, Gennaro; Dal Monte, Massimo; Nassini, Romina; Fontani, Filippo; Casini, Arianna; Cavallini, Lorenzo; Becatti, Matteo; Bianchini, Francesca; De Logu, Francesco; Forni, Giulia; la Marca, Giancarlo; Calorini, Lido; Bagnoli, Paola; Chiarugi, Paola; Pupi, Alberto; Azzari, Chiara; Geppetti, Pierangelo; Favre, Claudio; Filippi, Luca (2019). β3-adrenoceptor as a potential immuno-suppressor agent in melanoma. BRITISH JOURNAL OF PHARMACOLOGY, vol. 176, pp. 2509-2524, ISSN:1476-5381 DOI

Sernissi, Lorenzo; Ricci, Luciano; Scarpi, Dina; Bianchini, Francesca; Arosio, Daniela; Contini, Alessandro*; Occhiato, Ernesto G. (2018). Stereodivergent synthesis of 5-aminopipecolic acids and application in the preparation of a cyclic RGD peptidomimetic as a nanomolar αvβ3 integrin ligand. ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 16, pp. 3402-3414, ISSN:1477-0520 DOI Accesso ONLINE all'editore

JESSICA RUZZOLINI, SILVIA PEPPICELLI, FRANCESCA BIANCHINI, ELENA ANDREUCCI, ARIANNA SCARDIGLI, ANNALISA ROMANI, CHIARA NEDIANI, LIDO CALORINI (2018). Oleuropein affects braf melanoma cells and potentiates chemotherapy cytotoxicity. In: Polyphenols Applications, Bonn, 25-28 September 2018, ISANH, pp. 147-147, ISBN:9782356090126

Maggi, Vito; Bianchini, Francesca; Portioli, Elisabetta; Peppicelli, Silvia; Lulli, Matteo; Bani, Daniele; Del Sole, Roberta; Zanardi, Franca; Sartori, Andrea; Fiammengo, Roberto (2018). Gold nanoparticles functionalized with RGD-semipeptides: a simple yet highly effective targeting system for αVβ3 integrins. CHEMISTRY-A EUROPEAN JOURNAL, vol. 24, pp. 12093-12100, ISSN:0947-6539 DOI

Jessica Ruzzolini, Silvia Peppicelli, Elena Andreucci , Francesca Bianchini , Arianna Scardigli , Annalisa Romani , Giancarlo La Marca , Chiara Nediani , Lido Calorini (2018). Oleuropein, the Main Polyphenol of Olea europaea Leaf Extract, Has an Anti-Cancer Effect on Human BRAF Melanoma Cells and Potentiates the Cytotoxicity of Current Chemotherapies. NUTRIENTS, vol. 10, pp. 1-17, ISSN:2072-6643 DOI

Maura Calvani , Lorenzo Cavallini, Annalisa Tondo , Valentina Spinelli , Luisa Ricci , Amada Pasha , Gennaro Bruno , Daniela Buonvicino , Elisabetta Bigagli , Marina Vignoli , Francesca Bianchini , Laura Sartiani , Maura Lodovici , Roberto Semeraro, Filippo Fontani , Francesco De Logu , Massimo Dal Monte , Paola Chiarugi, Claudio Favre , and Luca Filippi (2018). "β3-Adrenoreceptors Control Mitochondrial Dormancy in Melanoma and Embryonic Stem Cells,. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, pp. 1-10, ISSN:1942-0900

Elena Andreucci, Silvia Pietrobono, Silvia Peppicelli, Jessica Ruzzolini, Francesca Bianchini, Alessio Biagioni, Barbara Stecca, Lido Calorini (2018). SOX2 as a novel contributor of oxidative metabolism in melanoma cells. CELL COMMUNICATION AND SIGNALING, vol. 13, pp. 1-13, ISSN:1478-811X DOI

J. Ruzzolini, S. Peppicelli, F.Bianchini, E. Andreucci, C. Nediani, L. Calorini. (2017). Oleuropein potentiates the cytotoxic activity of dacarbazine against melanoma cells.. In: Cancer Bio-Immunotherapy, NIBIT, pp. 0-0.

Ruzzolini, Jessica; Peppicelli, Silvia; Andreucci, Elena; Bianchini, Francesca; Margheri, Francesca; Laurenzana, Anna; Fibbi, Gabriella; Pimpinelli, Nicola; Calorini, Lido (2017). Everolimus selectively targets vemurafenib resistant BRAFV600E melanoma cells adapted to low pH. CANCER LETTERS, vol. 408, pp. 43-54, ISSN:0304-3835 DOI Accesso ONLINE all'editore

Andreucci, E; Bianchini, F; Biagioni, A; Del Rosso, M; Papucci, L; Schiavone, N; Magnelli, L. (2017). Roles of different IRES-dependent FGF2 isoforms in the acquisition of the major aggressive features of human metastatic melanoma. JOURNAL OF MOLECULAR MEDICINE, pp. 0-7, ISSN:0946-2716 DOI

Peppicelli, Silvia; Andreucci, Elena; Ruzzolini, Jessica; Margheri, Francesca; Laurenzana, Anna; Bianchini, Francesca; Calorini, Lido (2017). Acidity of Microenvironment as a Further Driver of Tumor Metabolic Reprogramming. JOURNAL OF CLINICAL & CELLULAR IMMUNOLOGY, vol. 8, pp. 0-5, ISSN:2155-9899 DOI

Sartori, A; Portioli, E; Battistini, L; Calorini, L; Pupi, A; Vacondio, F; Arosio, D; Bianchini, F; Zanardi, F (2017). Synthesis of Novel c(AmpRGD)-Sunitinib Dual Conjugates as Molecular Tools Targeting the αvβ3 Integrin/VEGFR2 Couple and Impairing Tumor-Associated Angiogenesis. JOURNAL OF MEDICINAL CHEMISTRY, vol. 60(1), pp. 248-262, ISSN:0022-2623

Laurenzana, A; Chillà, A; Luciani, C; Peppicelli, S; Biagioni, A; Bianchini, F; Tenedini, E; Torre, E; Mocali, A; Calorini, L; Margheri, F; Fibbi, G; Del Rosso, M. (2017). uPA/uPAR system activation drives a glycolytic phenotype in melanoma cells. INTERNATIONAL JOURNAL OF CANCER, vol. 141, pp. 1190-1200, ISSN:0020-7136 DOI Accesso ONLINE all'editore

Bianchini, Francesca; Peppicelli, Silvia; Fabbrizzi, Pierangelo; Biagioni, Alessio; Mazzanti, Benedetta; Menchi, Gloria; Calorini, Lido; Pupi, Alberto; Trabocchi, Andrea (2017). Triazole RGD antagonist reverts TGFβ1-induced endothelial-to-mesenchymal transition in endothelial precursor cells. MOLECULAR AND CELLULAR BIOCHEMISTRY, pp. 1-12, ISSN:0300-8177 DOI Accesso ONLINE all'editore

Andreucci, Elena; Peppicelli, Silvia; Carta, Fabrizio; Brisotto, Giulia; Biscontin, Eva; Ruzzolini, Jessica; Bianchini, Francesca; Biagioni, Alessio; Supuran, Claudiu T.; Calorini, Lido (2017). Carbonic anhydrase IX inhibition affects viability of cancer cells adapted to extracellular acidosis. JOURNAL OF MOLECULAR MEDICINE, vol. 95, pp. 1341-1353, ISSN:0946-2716 DOI Accesso ONLINE all'editore

Peppicelli, Silvia; Andreucci, Elena; Ruzzolini, Jessica; Laurenzana, Anna; Margheri, Francesca; Fibbi, Gabriella; Del Rosso, Mario; Bianchini, Francesca; Calorini, Lido (2017). The acidic microenvironment as a possible niche of dormant tumor cells. CELLULAR AND MOLECULAR LIFE SCIENCES, pp. 0-0, ISSN:1420-682X DOI

Ricci, Luciano; Sernissi, Lorenzo; Scarpi, Dina; Bianchini, Francesca; Contini, Alessandro; Occhiato, ERNESTO GIOVANNI (2017). Synthesis and conformational analysis of peptides embodying 2,3-methanopipecolic acids. ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 15, pp. 6826-6836, ISSN:1477-0520 DOI Accesso ONLINE all'editore

Margheri, Giancarlo; Zoppi, Angela; Olmi, Roberto; Trigari, Silvana; Traversi, Rita; Severi, Mirko; Bani, Daniele; Bianchini, Francesca; Torre, Eugenio; Margheri, Francesca; Chillà, Anastasia; Biagioni, Alessio; Calorini, Lido; Laurenzana, Anna; Fibbi, Gabriella; Del Rosso, Mario (2016). Tumor-tropic endothelial colony forming cells (ECFCs) loaded with near-infrared sensitive Au nanoparticles: A "cellular stove" approach to the photoablation of melanoma. ONCOTARGET, vol. 7, pp. 39846-39860, ISSN:1949-2553 DOI

Calvani, M; Bianchini, F; Taddei, Ml; Becatti, M; Giannoni, E; Chiarugi, P; Calorini, L1. (2016). Etoposide-Bevacizumab a new strategy against human melanoma cells expressing stem-like traits. ONCOTARGET, vol. 7(33), pp. 51138-51149, ISSN:1949-2553 DOI Accesso ONLINE all'editore

Andreucci, E.; Bianchini, F.; Biagioni, A.; Del Rosso, M.; Papucci, L.; Schiavone, N.; Magnelli, L. (2016). FGF2 in Human Melanoma Progression: The Antithetical Functions of Different Isoforms. THE AMERICAN JOURNAL OF PATHOLOGY, vol. 186, pp. 0-0, ISSN:0002-9440

Peppicelli, Silvia; Toti, Alessandra; Giannoni, Elisa; Bianchini, Francesca; Margheri, Francesca; Del Rosso, Mario; Calorini, Lido (2016). Metformin is also effective on lactic acidosis-exposed melanoma cells switched to oxidative phosphorylation. CELL CYCLE, vol. 15, pp. 1908-1918, ISSN:1538-4101 DOI

Sernissi, Lorenzo; Trabocchi, Andrea; Scarpi, Dina; Bianchini, Francesca; Occhiato, Ernesto G. (2016). Cyclic RGD peptidomimetics containing 4- and 5-aminocyclopropane pipecolic acid (CPA) templates as dual aVb3 and a5b1 integrin ligands. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 24, pp. 703-711, ISSN:1464-3391 DOI

Lenci, Elena; Innocenti, Riccardo; Biagioni, Alessio; Menchi, Gloria; Bianchini, Francesca; Trabocchi, Andrea (2016). Identification of novel human breast carcinoma (MDA-MB-231) Cell growth modulators from a carbohydrate-based diversity oriented synthesis library. MOLECULES, vol. 21, pp. 1405-1423, ISSN:1420-3049 DOI Accesso ONLINE all'editore

Peppicelli, Silvia; Bianchini, Francesca; Calorini, Lido (2015). Metabolic reprogramming as a continuous changing behavior of tumor cells. TUMOR BIOLOGY, vol. 36, pp. 5759-5762, ISSN:1010-4283 DOI Accesso ONLINE all'editore

Laurenzana, Anna; Biagioni, Alessio; Bianchini, Francesca; Peppicelli, Silvia; Chillà, Anastasia; Margheri, Francesca; Luciani, Cristina; Pimpinelli, Nicola; Del Rosso, Mario; Calorini, Lido; Fibbi, Gabriella (2015). Inhibition of uPAR-TGFβ crosstalk blocks MSC-dependent EMT in melanoma cells. JOURNAL OF MOLECULAR MEDICINE, vol. 93, pp. 783-794, ISSN:0946-2716 DOI Accesso ONLINE all'editore

Bianchini, Francesca; Fabbrizzi, Pierangelo; Menchi, Gloria; Raspanti, Silvia; Bottoncetti, Anna; Passeri, Alessandro; Andreucci, Elena; Guarna, Antonio; Calorini, Lido; Pupi, Alberto; Trabocchi, Andrea (2015). Radiosynthesis and micro-SPECT analysis of triazole-based RGD integrin ligands as non-peptide molecular imaging probes for angiogenesis. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 23, pp. 1112-1122, ISSN:0968-0896 DOI Accesso ONLINE all'editore

Sartori, Andrea; Bianchini, Francesca; Migliari, Silvia; Burreddu, Paola; Curti, Claudio; Vacondio, Federica; Arosio, Daniela; Ruffini, Livia; Rassu, Gloria; Calorini, Lido; Pupi, Alberto; Zanardi, Franca; Battistini, Lucia (2015). Synthesis and preclinical evaluation of a novel, selective 111In-labelled aminoproline-RGD-peptide for non-invasive melanoma tumor imaging. MEDCHEMCOMM, vol. 6, pp. 2175-2183, ISSN:2040-2503 DOI Accesso ONLINE all'editore

Sernissi, Lorenzo; Petrovic, Martina; Scarpi, Dina; Trabocchi, Andrea; Bianchini, Francesca; Occhiato, Ernesto Giovanni (2015). Cyclopropane pipecolic acids as templates for linear and cyclic peptidomimetics. AMINO ACIDS, vol. 47, pp. 1647-1647, ISSN:0939-4451 DOI

Bianchini, Francesca; Calugi, Chiara; Ruzzolini, Jessica; Menchi, Gloria; Calorini, Lido; Guarna, Antonio; Trabocchi, Andrea (2015). A study of a d-proline peptidomimetic inhibitor of melanoma and endothelial cell invasion through activity towards MMP-2 and MMP-9. MEDCHEMCOMM, vol. 6, pp. 277-282, ISSN:2040-2503 DOI Accesso ONLINE all'editore

Peppicelli, Silvia; Bianchini, Francesca; Calorini, Lido (2015). Dynamic scenario of metabolic pathway adaptation in tumors and therapeutic approach. ONCOSCIENCE, vol. 2, pp. 225-232, ISSN:2331-4737

Giannoni, E; Taddei, Ml; Morandi, A; Comito, G; Calvani, M; Bianchini, F; Richichi, B; Raugei, G; Wong, N; Tang, D; Chiarugi, P. (2015). Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs OXPHOS and prostate cancer metastatic spread. ONCOTARGET, vol. 6(27), pp. 24061-24074, ISSN:1949-2553 DOI Accesso ONLINE all'editore

Peppicelli, Silvia; Bianchini, Francesca; Toti, Alessandra; Laurenzana, Anna; Fibbi, Gabriella; Calorini, Lido (2015). Extracellular acidity strengthens mesenchymal stem cells to promote melanoma progression. CELL CYCLE, vol. 14, pp. 3088-100-3100, ISSN:1538-4101 DOI

Laurenzana, Anna; Cencetti, Francesca; Serratì, Simona; Bruno, Gennaro; Japtok, Lukasz; Bianchini, Francesca; Torre, Eugenio; Fibbi, Gabriella; Del Rosso, Mario; Bruni, Paola; Donati, Chiara . (2015). Endothelial sphingosine kinase/SPNS2 axis has a critical role in migration and vessel-like formation of human mesoangioblasts. JOURNAL OF MOLECULAR MEDICINE, vol. 93, pp. 1145-1157, ISSN:0946-2716 DOI

Laurenzana A; Biagioni A; D'Alessio S; Bianchini F; Chillà A; Margheri F; Luciani C; Mazzanti B; Pimpinelli N; Torre E; Danese S; Calorini L; Del Rosso M; Fibbi G (2014). Melanoma cell therapy: Endothelial progenitor cells as shuttle of the MMP12 uPAR-degrading enzyme. ONCOTARGET, vol. 5, pp. 3711-3727, ISSN:1949-2553 Accesso ONLINE all'editore

Antonella Lupia;Silvia Peppicelli;Ewa Witort;Francesca Bianchini;Vinicio Carloni;Nicola Pimpinelli;Carmelo Urso;Lorenzo Borgognoni;Sergio Capaccioli;Lido Calorini;Matteo Lulli (2014). CD63 Tetraspanin Is a Negative Driver of Epithelial-to-Mesenchymal Transition in Human Melanoma Cells. JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 134, pp. 2947-2956, ISSN:0022-202X DOI

Fabbrizzi, Pierangelo; Bianchini, Francesca; Menchi, Gloria; Raspanti, Silvia; Guarna, Antonio; Trabocchi, Andrea (2014). Combination of click chemistry and sulfonamides to develop three-armed triazole compounds. TETRAHEDRON, vol. 70, pp. 5439-5449, ISSN:0040-4020 DOI Accesso ONLINE all'editore

Lorenzo Sernissi; Martina Petrovic; Dina Scarpi; Antonio Guarna; Andrea Trabocchi; Francesca Bianchini; Ernesto G. Occhiato (2014). Cyclopropane Pipecolic Acids as Templates for Linear and Cyclic Peptidomimetics: Application in the Synthesis of an Arg-Gly-Asp (RGD)-Containing Peptide as an αvβ3 Integrin Ligand. CHEMISTRY-A EUROPEAN JOURNAL, vol. 20, pp. 11187-11203, ISSN:0947-6539 DOI Accesso ONLINE all'editore

Rovida E; Peppicelli S; Bono S; Bianchini F; Tusa I; Cheloni G; Marzi I; Cipolleschi MG; Calorini L; Dello Sbarba P (2014). The metabolically-modulated stem cell niche: a dynamic scenario regulating cancer cell phenotype and resistance to therapy.. CELL CYCLE, vol. 13, pp. 3169-3175, ISSN:1538-4101 DOI Accesso ONLINE all'editore

Peppicelli S; Bianchini F; Calorini L (2014). Extracellular acidity, a "reappreciated" trait of tumor environment driving malignancy: perspectives in diagnosis and therapy.. CANCER METASTASIS REVIEWS, vol. 33, pp. 823-832, ISSN:0167-7659 DOI Accesso ONLINE all'editore

Peppicelli S; Bianchini F; Calorini L (2014). Inflammatory cytokines induce vascular endothelial growth factor-C expression in melanoma-associated macrophages and stimulate melanoma lymph node metastasis. ONCOLOGY LETTERS, vol. 8, pp. 1133-1138, ISSN:1792-1074 DOI Accesso ONLINE all'editore

Peppicelli S; Bianchini F; Torre E; Calorini L (2014). Contribution of acidic melanoma cells undergoing epithelial-to-mesenchymal transition to aggressiveness of non-acidic melanoma cells.. CLINICAL & EXPERIMENTAL METASTASIS, vol. 31, pp. 423-433, ISSN:0262-0898 DOI Accesso ONLINE all'editore

Matteo Parri; Laura Pietrovito; Alberto Grandi; Susanna Campagnoli; Elisa De Camilli; Francesca Bianchini; Serena Marchiò; Federico Bussolino ; Boquan Jin; Paolo Sarmientos; Guido Grandi; Giuseppe Viale; Piero Pileri; Paola Chiarugi; Renata Grifantini. (2014). Angiopoietin like 7, a novel pro-angiogenetic factor over-expressed in cancer. ANGIOGENESIS, pp. 0-0, ISSN:0969-6970 DOI

Giusti, Betti; Margheri, Francesca; Rossi, Luciana; Lapini, Ilaria; Magi, Alberto; Serratã¬, Simona; Chillã , Anastasia; Laurenzana, Anna; Magnelli, Lucia; Calorini, Lido; Bianchini, Francesca; Fibbi, Gabriella; Abbate, Rosanna; Mario Del, Rosso (2013). Correction: Desmoglein-2-integrin Beta-8 interaction regulates actin assembly in endothelial cells: Deregulation in Systemic sclerosis (PLoS ONE (2013) 8, 7, (e68117) doi: 10.1371/journal.pone.0068117). PLOS ONE, vol. 8, pp. 0-0, ISSN:1932-6203 DOI Accesso ONLINE all'editore

Giusti, B; Margheri, F; Rossi, L; Lapini, I; Magi, A; Serratì, S; Chillà, A; Laurenzana, A; Magnelli, L; Calorini, L; Bianchini, F; Fibbi, G; Abbate, R; Del Rosso, M (2013). Desmoglein-2-integrin Beta-8 interaction regulates actin assembly in endothelial cells: deregulation in systemic sclerosis. PLOS ONE, vol. 8, pp. 1-13, ISSN:1932-6203 DOI

Peppicelli S; Bianchini F; Contena C; Tombaccini D; Calorini L (2013). Acidic pH via NF-κB favours VEGF-C expression in human melanoma cells. CLINICAL & EXPERIMENTAL METASTASIS, pp. 0-0, ISSN:0262-0898 DOI

Marconi C; Peppicelli S; Bianchini F; Calorini L. (2013). TNFα receptor1 drives hypoxia-promoted invasiveness of human melanoma cells. EXPERIMENTAL ONCOLOGY, vol. 35, pp. 187-191, ISSN:1812-9269

Giannoni E; Taddei ML; Parri M; Bianchini F; Santosuosso M; Grifantini R; Fibbi G; Mazzanti B; Calorini L; Chiarugi P. (2013). EphA2-mediated mesenchymal-amoeboid transition induced by endothelial progenitor cells enhances metastatic spread due to cancer-associated fibroblasts.. JOURNAL OF MOLECULAR MEDICINE, vol. 91(1), pp. 103-115, ISSN:0946-2716

A. P. Femia; C. Luceri; F. Bianchini; M. Salvadori; P. Dolara; L. Calorini; G. Caderni (2012). Polyphenol-rich Marie Ménard apples and a low fat diet reduce 1,2-dimethylhydrazine induced colon carcinogenesis in rats: effects on inflammation and apoptosis.. In: International Conference on Polyphenols- ICP 2012, Firenze, Italia, 22-26 luglio 2012, vol. 2, pp. 469-470.

F.Margheri;N.Schiavone;L.Papucci;L.Magnelli;S.Serratì;A.Chillà;A.Laurenzana;F.Bianchini;L.Calorini;J.Dotor;E.Feijoo;G.Fibbi;M.Del Rosso (2012). Bone Morphogenetic Protein-14 Regulates TGF-β-Dependent Angiogenesis in Breast Carcinoma MCF-7 Cells: In Vitro and in Vivo Control by Anti-TGF-β Peptides. In: SIPMeT, Udine, 12-15/09/2012, Elsevier, vol. 181, pp. S19-S19. Accesso ONLINE all'editore

Margheri F;Schiavone N;Papucci L;Magnelli L;Serratì S;Chillà A;Laurenzana A;Bianchini F;Calorini L;Torre E;Dotor J;Feijoo E;Fibbi G; Del Rosso M (2012). GDF5 regulates TGFß-dependent angiogenesis in breast carcinoma MCF-7 cells: in vitro and in vivo control by anti-TGFß peptides. PLOS ONE, vol. ?, pp. 0-0, ISSN:1932-6203 Accesso ONLINE all'editore

Bianchini F; Giannoni E; Serni S; Chiarugi P; Calorini L. (2012). 22 : 6n-3 DHA inhibits differentiation of prostate fibroblasts into myofibroblasts and tumorigenesis.. BRITISH JOURNAL OF NUTRITION, vol. 108, pp. 2129-2137, ISSN:1475-2662 DOI

A. P. Femia; C. Luceri; F. Bianchini; M. Salvadori; F. Salvianti; P. Pinzani; P. Dolara; L. Calorini; G. Caderni (2012). Marie Ménard apples with high polyphenol content and a low-fat diet reduce 1,2-dimethylhydrazine-induced colon carcinogenesis in rats: Effects on inflammation and apoptosis.. MOLECULAR NUTRITION & FOOD RESEARCH, vol. 56, pp. 1353-1357, ISSN:1613-4125 DOI

Bianchini F; Cini N; Trabocchi A; Bottoncetti A; Raspanti S; Vanzi E; Menchi G; Guarna A; Pupi A; Calorini L. (2012). ¹²⁵I-radiolabeled morpholine-containing arginine-glycine-aspartate (RGD) ligand of αvβ₃ integrin as a molecular imaging probe for angiogenesis.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, pp. 5024-5033, ISSN:0022-2623 DOI Accesso ONLINE all'editore

L. Calorini; S. Peppicelli; F. Bianchini (2012). Extracellular acidity as favouring factor of tumor progression and metastatic dissemination. EXPERIMENTAL ONCOLOGY, vol. 34 (2), pp. 79-84, ISSN:1812-9269

E. Giannoni; F. Bianchini; L. Calorini; P. Chiarugi (2011). Cancer associated fibroblasts exploit reactive oxygen species through a proinflammatory signature leading to epithelial mesenchymal transition and stemness.. ANTIOXIDANTS & REDOX SIGNALING, vol. 14(12), pp. 2361-2371, ISSN:1523-0864

Taddei ML; Parri M; Angelucci A; Bianchini F; Marconi C; Giannoni E; Raugei G; Bologna M; Calorini L; Chiarugi P (2011). EphA2 induces metastatic growth regulating amoeboid motility and clonogenic potential in prostate carcinoma cells. MOLECULAR CANCER RESEARCH, vol. 9(2), pp. 149-160, ISSN:1541-7786

F.Margheri; A.Chillà; A.Laurenzana; S.Serratì; B.Mazzanti; R.Saccardi; M.Santosuosso; G.Danza; N.Sturli; F.Rosati; L.Magnelli; L.Papucci; L.Calorini; F.Bianchini; M.Del Rosso; G.Fibbi. (2011). Endothelial progenitor cell-dependent angiogenesis requires localization of the full-length form of uPAR in caveolae.. BLOOD, vol. 118, pp. 3743-3755, ISSN:0006-4971 DOI Accesso ONLINE all'editore

G. Comito; M. Calvani; E. Giannoni; F. Bianchini; L. Calorini; E. Torre; C. Migliore; S. Giordano; P. Chiarugi (2011). HIF-1α stabilization by mitochondrial ROS promotes Met-dependent invasive growth and vasculogenic mimicry in melanoma cells.. FREE RADICAL BIOLOGY & MEDICINE, vol. 51(4), pp. 893-904, ISSN:0891-5849 DOI

E. Giannoni; F. Bianchini; L. Masieri;S. Serni; E. Torre; L. Calorini; P. Chiarugi (2010). Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness.. CANCER RESEARCH, vol. 70(17), pp. 6945-6956, ISSN:0008-5472 DOI

Calorini L; Bianchini F (2010). Environmental control of invasiveness and metastatic dissemination of tumor cells: the role of tumor cell-host cell interactions. CELL COMMUNICATION AND SIGNALING, pp. 0-0, ISSN:1478-811X DOI Accesso ONLINE all'editore

Trabocchi, Andrea; Menchi, Gloria; Cini, Nicoletta; Bianchini, Francesca; Raspanti, Silvia; Bottoncetti, Anna; Pupi, Alberto; Calorini, Lido; Guarna, Antonio (2010). Click-chemistry-derived triazole ligands of arginine−glycine−aspartate (RGD) integrins with a broad capacity to inhibit adhesion of melanoma cells and both in vitro and in vivo angiogenesis. JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, pp. 7119-7128, ISSN:0022-2623 DOI Accesso ONLINE all'editore

F.Margheri; S.Serrati; A.Lapucci; A.Chilla; L.Bazzichi ; S.Bombardieri; B.Kahaleh ; L.Calorini ; F.Bianchini; G.Fibbi; M.Del Rosso M (2010). Modulation of the angiogenic phenotype of normal and systemic sclerosis endothelial cells by gain-loss of function of pentraxin 3 and matrix metalloproteinase 12. ARTHRITIS AND RHEUMATISM, vol. 62, pp. 2488-2498, ISSN:0004-3591 DOI Accesso ONLINE all'editore

Margheri F; Serratì S; Lapucci A; Anastasia C; Giusti B; Pucci M; Torre E; Bianchini F; Calorini L; Albini A; Ventura A; Fibbi G; Del Rosso M. (2009). Systemic sclerosis-endothelial cell antiangiogenic pentraxin 3 and matrix metalloprotease 12 control human breast cancer tumor vascularization and development in mice.. NEOPLASIA, vol. 11, pp. 1106-1115, ISSN:1522-8002 DOI Accesso ONLINE all'editore

M.Parri; ML.Taddei; F.Bianchini; L.Calorini; P.Chiarugi (2009). EphA2 reexpression prompts invasion of melanoma cells shifting from mesenchymal to amoeboid-like motility style. CANCER RESEARCH, vol. 69, pp. 2072-2081, ISSN:0008-5472

ML.Taddei; M.Parri; A.Angelucci; B.Onnis; F.Bianchini; E.Giannoni; G.Raugei; L.Calorini; N.Rucci; A.Teti; M.Bologna; P.Chiarugi. (2009). Kinase-dependent and -independent roles of EphA2 in the regulation of prostate cancer invasion and metastasis. THE AMERICAN JOURNAL OF PATHOLOGY, vol. 174, pp. 1492-1503, ISSN:0002-9440

Marconi C; Bianchini F; Mannini A; Mugnai G; Ruggieri S; Calorini L. (2008). Tumoral and macrophage uPAR and MMP-9 contribute to the invasiveness of B16 murine melanoma cells. CLINICAL & EXPERIMENTAL METASTASIS, vol. 25(3), pp. 225-231, ISSN:0262-0898 DOI Accesso ONLINE all'editore

Gloria Rossoni; Chiara Marconi; Francesca Bianchini; Antonella Mannini; Gabriele Mugnai; Salvatore Ruggieri; Lido Calorini (2007). Hypoxia-mediated overexpression of cytokine receptors: a mechanism of tumor progression in B16 melanoma cells. In: Tumor Microenvironment: Progression, Therapy and Prevention, Florence (I), March 6-10, 2007, I.P. Witz, pp. 143-143, ISBN:9788875873462

D. Massi; C. Marconi; A. Franchi; F. Bianchini; M. Paglieriani; S. Ketabchi; C. Miracco; M. Santucci; L. Calorini (2007). Arginine metabolism in tumor-associated macrophages in cutaneous malignant melanoma: evidence from human and experimental tumors.. HUMAN PATHOLOGY, vol. 38, pp. 1516-1525, ISSN:0046-8177 DOI Accesso ONLINE all'editore

Bianchini, Francesca; Massi, Daniela; Marconi, C.; Franchi, Alessandro; Baroni, G.; Santucci, Marco; Mugnai, G.; Calorini, Lido (2007). Expression of cyclo-oxygenase-2 in macrophages associated with cutaneous melanoma at different stages of progression. PROSTAGLANDINS & OTHER LIPID MEDIATORS, vol. 83, pp. 320-328, ISSN:1098-8823 DOI Accesso ONLINE all'editore

Chiara Marconi; Francesca Bianchini; Antonella Mannini; Gabriele Mugnai; Salvatore Ruggieri; Lido Calorini (2006). Tumor cells and tumor-associated macrophages contribute to the generation of the uPA system and MMP-9. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 18 (1), pp. S54-S54, ISSN:1107-3756

F. Bianchini; A. Mannini; G. Mugnai; S. Ruggieri; L. Calorini (2006). Expression of a metastatic phenotype in IFNs-primed/TNFalpha-activated B16 murine melanoma cells: role of JAK1/PKCdelta signal transduction factors.. CLINICAL & EXPERIMENTAL METASTASIS, vol. 23, pp. 203-208, ISSN:0262-0898 DOI Accesso ONLINE all'editore

F. Bianchini ; S. D'Alessio; G. Fibbi; M. Del Rosso; L. Calorini (2006). Cytokine-dependent invasiveness in B16 murine melanoma cells: role of uPA system and MMP-9.. ONCOLOGY REPORTS, vol. 15, pp. 709-714, ISSN:1021-335X Accesso ONLINE all'editore

M. Arita; F. Bianchini; J. Aliberti; A. Sher; N. Chiang; S. Hong; R. Yang; N. Petasis; C. Serhan (2005). Stereochemical Assignment, Anti-Inflammatory Properties, and Receptor for the Omega-3 Lipid Mediator Resolvin E1. JOURNAL OF EXPERIMENTAL MEDICINE, vol. 201, pp. 713-722, ISSN:0022-1007 Accesso ONLINE all'editore

Calorini, Lido; Bianchini, Francesca; Mugnai, G.; Ruggieri, S. (2005). Inhibition of lipoxygenase pathway in macrophages co-cultivated with tumor cells. CANCER LETTERS, vol. 223, pp. 151-158, ISSN:0304-3835 DOI Accesso ONLINE all'editore

L. CALORINI; F. BIANCHINI; A. MANNINI; G. MUGNAI; S. RUGGIERI (2005). Enhancement of nitric oxide release in mouse inflammatory macrophages co-cultivated with tumor cells of a different origin.. CLINICAL & EXPERIMENTAL METASTASIS, vol. 22, pp. 413-419, ISSN:0262-0898 DOI Accesso ONLINE all'editore

Bertini I;Bianchini F;Calorini L;Colagrande S;Fragai M;Franchi A;Gallo O;Gavazzi C;Luchinat C (2004). Persistent contrast enhancement by sterically stabilized paramagnetic liposomes in murine melanoma.. MAGNETIC RESONANCE IN MEDICINE, vol. 52, pp. 669-672, ISSN:0740-3194 DOI

Lido Calorini; Francesca Bianchini; Antonella Mannini; Gabriele Mugnai; Salvatore Ruggieri (2004). Changes of the secretion of NO and TNFalpha by peritoneal murine inflammatory macrophages co-cultivated with B16 melanoma cells. TUMORI, vol. 3 (1), pp. 95-95, ISSN:0300-8916

L. Calorini; F. Bianchini; A. Mannini; G. Mugnai; M. Balzi; A. Becciolini; S. Ruggieri (2002). IFNgamma and TNFalpha account for a pro-clonogenic activity secreted by activated murine peritoneal macrophages.. CLINICAL & EXPERIMENTAL METASTASIS, vol. 19, pp. 259-264, ISSN:0262-0898 DOI Accesso ONLINE all'editore

L. Calorini;A. Mannini; F. Bianchini; G. Mugnai; S. Ruggieri (2000). The change in leukotrienes and lipoxins in activated mouse peritoneal macrophages. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, vol. 1484, pp. 87-92, ISSN:1388-1981 DOI Accesso ONLINE all'editore

Lido Calorini; Antonella Mannini; Francesca Bianchini; Gabriele Mugnai; Salvatore Ruggieri (1999). Lipoxygenase products of murine peritoneal macrophages at different levels of activation. In: 6th International Conference on Eicosanoids and Othr Bioactive Lipids in cancer, Inflammation and Related Disease, Boston, 12-15 September, 1999, New York, Elsevier, vol. 4, pp. 59-59, ISBN:0306461382

Calorini, Lido; Bianchini, Francesca; Mugnai, G.; Balzi, M.; Becciolini, A.; Ruggieri, S. (1999). Biological properties associated with the enhanced lung-colonizing potential in a B16 murine melanoma line grown in a medium conditioned by syngeneic Corynebacterium parvum-elicited macrophages. CLINICAL & EXPERIMENTAL METASTASIS, vol. 10, pp. 889-895, ISSN:0262-0898 Accesso ONLINE all'editore

Lido Calorini; Antonella Mannini; Francesca Bianchini; Gabriele Mugnai; Manuela Balzi; Aldo Becciolini; Salvatore Ruggieri (1999). Biological properties of a murine melanoma line (B16-F10 cells) stimulated by a proclonogenic activity released by Corynebacterium parvum-elicited macrophages. CLINICAL & EXPERIMENTAL METASTASIS, vol. 17, pp. 755-755, ISSN:0262-0898 Accesso ONLINE all'editore

M. Balzi; P. Faraoni; G.D. Zappoli Thyrion; L. Corsani; E. Tisti; S. Bianchi; P. Pacini; F. Bianchini; L. Rinaldi; A. Becciolini (1997). TLI and SPF in breast carcinoma.. In: Convegno, vol. Cell Prolif. vol. 30, pp. 472-472.

Francesca BIANCHINI

Curriculum

PERSONAL INFORMATION	Francesca Bianchini

	University of Florence Department of Experimental and Clinical Biomedical Sciences Viale Morgagni, 50 - 50134 Florence, ITALY
	+39-055-2751310 +39-339 7418663
	francesca.bianchini@unifi.it
	https://www.sbsc.unifi.it/vp-341-gruppo-bianchini.html
	Sex Female \| Date of birth 05/09/1971\| NationalityItalian

Enterprise	University	EPR
☐Management Level	☐Full professor	☐Research Director and 1st level Technologist / First Researcher and 2nd level Technologist / Principal Investigator
☐Mid-Management Level	☒Associate Professor	☐Level III Researcher and Technologist
☐Employee / worker level	☐Researcher and Technologist of IV, V, VI and VII level / Technical collaborator	☐Researcher and Technologist of IV, V, VI and VII level / Technical collaborator

PERSONAL STATEMENT

Francesca Bianchini is an Associate Professor in General Pathology at the University of Florence involved in teaching to Medicine and Surgery, and Nursing students. After graduating in Biological Sciences, she received her training on preclinical oncology, under the supervision of Prof. Calorini, at the University of Florence. She obtained her PhD in Experimental Pathology from the University of Florence in 2002. During her PhD, she attended the laboratory of Prof. Charles N. Serhan at the B&WH Harvard Medical School in Boston (MA). Her post-doctoral research has been extensively focused on preclinical oncology and translational medicine.

RESEARCH INTERESTS

Translational medicinal chemistry; integrin antagonist as tools for targeted drug delivery and non-invasive medical imaging
Preclinical Oncology, Translational Medicine and In vivo Imaging
Nanomedicine and personalized cell-therapy
Tumor microenvironment factors in cancer progression metabolism and resistance to therapy.

WORK EXPERIENCE
15/07/2024	Director of the Interdepartmental Research Center on Biomedical Imaging - CIRIB - of the University of Florence
2023-today	Associate Professor
	Department of Clinical and Experimental Biomedical Sciences, University of Florence

2020-2023	RTDb Researcher
2020-2023	Department of Clinical and Experimental Biomedical Sciences, University of Florence
2018-2020	RTDa Researcher
2018-2020	Department of Clinical and Experimental Biomedical Sciences, University of Florence
2004-2017	Research Fellow
2004-2017	Department of Clinical and Experimental Biomedical Sciences, University of Florence
2002-2003	Visiting Research Fellow
	Laboratory of Professor Charles N. Serhan, Center for Experimental Therapeutics & Reperfusion Injury, Brigham & Women's Hospital, Harvard Medical School, Boston, MA
	▪ Identification and structural-functional characterization of bioactive metabolites derived from eicosapentaenoic acid (EPA) and their receptors in different populations of inflammatory cells”
	Resolvins, and other potent anti-inflammatory and pro-resolving mediators

EDUCATION AND TRAINING

2017	Degree of Specialization in “Clinical Biochemistry” University of Tor Vergata Rome, Italy
	▪ Radioisotope manipulation: radioisotope conjugation of bioactive small molecules for molecular imaging.
1998-2002	PhD in Experimental Pathology, University of Florence
	▪ In vivo experimentation: small animal experimentation; subcutaneous, intramuscular, intravenous and intracardiac injections
	▪ Trained for hazards associated with ionizing radiations, and trained in the precautions to be taken when employing ionizing radiation, and in the methods of protection.
1997-1998	Graduated training in Radiation Biology
	▪ Evaluation of the proliferative activity using 3H-thymidine uptake.
1997	Degree in Biological Science
	▪ Molecular and cellular biology techniques (BL3); flow-cytometry and immunofluorescence, TLC, HPLC, GC, GC / MS and LC / MS. In vivo experimental procedures

WORK ACTIVITIES

Awards	2000 Young Researcher Award 2000: “Characterization of Activated Macrophages pro-metastatic activity”
Editorial activity	2021- Cancers (MDPI): Special Issue "New Insight in TME-Cancer Cells Crosstalk: The Impact of Gender on Cancer Progression and Response to Therapy"
Invited presentations	Second Chianti Meeting on Proteases. 16-20 Maggio 2004, Pontignano (Siena). Epigenetic control of invasiveness in B16 melanoma cells: role of inflammatory cytokines. 16-20/05/2004 Melanoma and Non Melanoma Skin Cancer, Hot topics 2015. Relatrice: SPECT imaging preclinico nel melanoma 16-18/04/2015 SIPMet Young Scientific Meeting - Alba 11-12 September 2015. 33° CONGRESSO NAZIONALE SIPMET, Società Italiana di Patologia e Medicina Traslazionale, Montesilvano (PE), 4-5-6 Ottobre 2016 – cAmpRGD-Sunitinib Conjugates as Integrin Targeted Delivery Strategy for Inhibition of Angiogenesis and Tumor Growth Cancers / 2nd International Electronic Conference (IECC 2022): “Tumor Microenvironment Heterogeneity in Cancer Progression: Challenge or Opportunity”. Title presentation: “Novel αvβ6-integrin ligands conjugated with nintedanib reduce TGFβ-induced EMT of human non-small cell lung cancer” 14-16/02/2022
Grants	2022 PNRR Funded: IDENTIFICATION AND TARGETING WITH RNA-BASED APPROACH OF METABOLIC DEPENDENT AND INDEPENDENT PATHWAYS, CN3_spoke2, 2022 PRIN FundedInnovative therapeutic interventions against Idiopathic Pulmonary Fibrosis. Role PI 2020 – Funded project from University of Florence – Title: Cancer-induced bone pain in a murine model of breast carcinoma: role of Transient Receptor Potential channels. Role: co-PI. 2018 - Funded project from Fondazione Cassa di Risparmio di Firenze - Title: Synthesis of novel anti-fibrotic agents for the treatment of Idiopathic Pulmonary Fibrosis. Role: PI
Technology transfer activities - spin-off	2015-2021 Co-Founder IMADROM srl – Imaging Technologies- innovative startup