Marco CAREMANI

Ruolo attuale:: Professore Associato
SSD:: BIOS-06/A - Fisiologia
Afferenza organizzativa:: Dipartimento di Biologia

Recapiti

marco.caremani(AT)unifi.it

Ulteriori Recapiti

	Via Madonna del Piano, 6 - 50019 Sesto Fiorentino
	055 4574753 - 055 4574757
	marco.caremani(AT)unifi.it

Marco CAREMANI

Orario di ricevimento (aggiornato al 29/08/2022)

Venerdì pomeriggio (15.00-18.00), stanza B.1.16 Dipartimento di Biologia (Polo Scientifico di Sesto Fiorentino)

Marco CAREMANI

Curriculum

Marco Caremani

ORCID 0000-0001-9128-7227

2008 Dottorato di ricerca in Scienze Fisiologiche e Nutrizionali, Dipartimento di Fisiologia Università di Firenze

2003 Laurea in Scienze Naturali Università di Firenze

Posizione Corrente

2017 – Ricercatore Dipartimento di Biologia, Università di Firenze

Posizioni Precedenti

2009 – 2017 Postdoc Dipartimento di Biologia, Università di Firenze

2008 – 2009 Postdoc Research Associate, nel laboratorio del Professor Michael Ferenczi,

National Heart and Lung Institute, Imperial College London

Appartenenza a Società Scientifiche

2015 – Società Italiana di Fisiologia

2010 – Biophysical Society, USA

Attività Scientifica

L'attività scientifica riguarda lo studio del meccanismo molecolare della contrazione del muscolo striato (cardiaco e scheletrico), la sua regolazione. Questo obiettivo è perseguito integrando tecniche di meccanica muscolare ad alta risoluzione e diffrazione a raggi X con luce di sincrotrone su singole fibre muscolari e trabecole cardiache.

Marco CAREMANI

Pubblicazioni

Legenda

Contributo su rivista |

Articolo su libro |

Libro |

Contributo in atti di convegno (proceeding) |

Brevetto |

Curatela | Altro

Altro |

Tesi di Dottorato

Ilaria Morotti, Marco Caremani, Matteo Marcello, Irene Pertici, Caterina Squarci, Pasquale Bianco, Theyencheri Narayanan, Gabriella Piazzesi, Massimo Reconditi, Vincenzo Lombardi, Marco Linari (In corso di stampa). An integrated picture of the structural pathways controlling the heart performance. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, pp. 0-0, ISSN:1091-6490

Buonfiglio, Valentina; Pertici, Irene; Marcello, Matteo; Morotti, Ilaria; Caremani, Marco; Reconditi, Massimo; Linari, Marco; Fanelli, Duccio; Lombardi, Vincenzo; Bianco, Pasquale (2024). Force and kinetics of fast and slow muscle myosin determined with a synthetic sarcomere–like nanomachine. COMMUNICATIONS BIOLOGY, vol. 7, pp. 0-0, ISSN:2399-3642 DOI

Marcello M.; Cetrangolo V.; Morotti I.; Squarci C.; Caremani M.; Reconditi M.; Savarese M.; Bianco P.; Piazzesi G.; Lombardi V.; Udd B.; Conte I.; Nigro V.; Linari M. (2024). Sarcomere level mechanics of the fast skeletal muscle of the medaka fish larva. AMERICAN JOURNAL OF PHYSIOLOGY, vol. 326, pp. C632-C644, ISSN:1522-1563 DOI

Pertici, Irene; Bongini, Lorenzo; Caremani, Marco; Reconditi, Massimo; Linari, Marco; Piazzesi, Gabriella; Lombardi, Vincenzo; Bianco, Pasquale (2023). Matching Mechanics and Energetics of Muscle Contraction Suggests Unconventional Chemomechanical Coupling during the Actin-Myosin Interaction. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 24, pp. 0-0, ISSN:1422-0067 DOI

Caremani, Marco; Fusi, Luca; Reconditi, Massimo; Piazzesi, Gabriella; Narayanan, Theyencheri; Irving, Malcolm; Lombardi, Vincenzo; Linari, Marco; Brunello, Elisabetta (2023). Dependence of myosin filament structure on intracellular calcium concentration in skeletal muscle. JOURNAL OF GENERAL PHYSIOLOGY, vol. 155, pp. 0-0, ISSN:0022-1295 DOI Accesso ONLINE all'editore

Squarci, Caterina; Bianco, Pasquale; Reconditi, Massimo; Pertici, Irene; Caremani, Marco; Narayanan, Theyencheri; Horváth, Ádám I; Málnási-Csizmadia, András; Linari, Marco; Lombardi, Vincenzo; Piazzesi, Gabriella (2023). Titin activates myosin filaments in skeletal muscle by switching from an extensible spring to a mechanical rectifier. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 120, pp. 0-0, ISSN:1091-6490 DOI Accesso ONLINE all'editore

Marco Caremani , Matteo Marcello , Ilaria Morotti , Irene Pertici , Caterina Squarci , Massimo Reconditi , Pasquale Bianco , Gabriella Piazzesi , Vincenzo Lombardi, Marco Linari (2022). The force of the myosin motor sets cooperativity in thin filament activation of skeletal muscles. COMMUNICATIONS BIOLOGY, pp. 0-0, ISSN:2399-3642 DOI

Caremani M.; Reconditi M. (2022). Anisotropic Elasticity of the Myosin Motor in Muscle. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, pp. 0-0, ISSN:1661-6596 DOI Accesso ONLINE all'editore

Caremani M.; Fusi L.; Linari M.; Reconditi M.; Piazzesi G.; Irving T.C.; Narayanan T.; Irving M.; Lombardi V.; Brunello E. (2021). Dependence of thick filament structure in relaxed mammalian skeletal muscle on temperature and interfilament spacing. JOURNAL OF GENERAL PHYSIOLOGY, vol. 153, pp. 0-0, ISSN:0022-1295 DOI Accesso ONLINE all'editore

Pertici, Irene; Taft, Manuel H; Greve, Johannes N; Fedorov, Roman; Caremani, Marco; Manstein, Dietmar J (2021). Allosteric modulation of cardiac myosin mechanics and kinetics by the conjugated omega-7,9 trans-fat rumenic acid. THE JOURNAL OF PHYSIOLOGY, vol. 599, pp. 3639-3661, ISSN:1469-7793 DOI

Governali, Serena; Caremani, Marco; Gallart, Cristina; Pertici, Irene; Stienen, Ger; Piazzesi, Gabriella; Ottenheijm, Coen; Lombardi, Vincenzo; Linari, Marco (2020). Orthophosphate increases the efficiency of slow muscle-myosin isoform in the presence of omecamtiv mecarbil. NATURE COMMUNICATIONS, vol. 11, pp. 3405-3417, ISSN:2041-1723 DOI Accesso ONLINE all'editore

Filomena, Maria Carmela; Yamamoto, Daniel L; Caremani, Marco; Kadarla, Vinay K; Mastrototaro, Giuseppina; Serio, Simone; Vydyanath, Anupama; Mutarelli, Margherita; Garofalo, Arcamaria; Pertici, Irene; Knöll, Ralph; Nigro, Vincenzo; Luther, Pradeep K; Lieber, Richard L; Beck, Moriah R; Linari, Marco; Bang, Marie-Louise (2020). Myopalladin promotes muscle growth through modulation of the serum response factor pathway. JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE, pp. 169-194, ISSN:2190-5991 DOI

Caremani, Marco; Pinzauti, Francesca; Powers, Joseph D.; Governali, Serena; Narayanan, Theyencheri; Stienen, Ger J.M.; Reconditi, Massimo; Linari, Marco; Lombardi, Vincenzo*; Piazzesi, Gabriella (2019). Inotropic interventions do not change the resting state of myosin motors during cardiac diastole. JOURNAL OF GENERAL PHYSIOLOGY, vol. 151, pp. 53-65, ISSN:0022-1295 DOI Accesso ONLINE all'editore

Caremani, Marco; Brunello, Elisabetta; Linari, Marco; Fusi, Luca; Irving, Thomas C; Gore, David; Piazzesi, Gabriella; Irving, Malcolm; Lombardi, Vincenzo; Reconditi, Massimo (2019). Low temperature traps myosin motors of mammalian muscle in a refractory state that prevents activation. JOURNAL OF GENERAL PHYSIOLOGY, vol. 151, pp. 1272-1286, ISSN:0022-1295 DOI

Pertici, Irene; Caremani, Marco; Reconditi, Massimo* (2019). A mechanical model of the half-sarcomere which includes the contribution of titin. JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, vol. 40 (1), pp. 29-41, ISSN:0142-4319, SPRINGER: DOI Accesso ONLINE all'editore

Reconditi, Massimo; Fusi, Luca; Caremani, Marco; Brunello, Elisabetta; Linari, Marco; Piazzesi, Gabriella; Lombardi, Vincenzo; Irving, Malcolm* (2019). Thick Filament Length Changes in Muscle Have Both Elastic and Structural Components. BIOPHYSICAL JOURNAL, vol. 116, pp. 983-984, ISSN:0006-3495 DOI Accesso ONLINE all'editore

Percario, Valentina; Boncompagni, Simona; Protasi, Feliciano; Pertici, Irene; Pinzauti, Francesca; Caremani, Marco* (2018). Mechanical parameters of the molecular motor myosin II determined in permeabilised fibres from slow and fast skeletal muscles of the rabbit. THE JOURNAL OF PHYSIOLOGY, vol. 596, pp. 1243-1257, ISSN:0022-3751 DOI Accesso ONLINE all'editore

Gabriella Piazzesi, Marco Caremani, Marco Linari, Massimo Reconditi, Vincenzo Lombardi (2018). Thick Filament Mechano-Sensing in Skeletal and Cardiac Muscles: A Common Mechanism Able to Adapt the Energetic Cost of the Contraction to the Task. FRONTIERS IN PHYSIOLOGY, vol. 9, pp. 1-7, ISSN:1664-042X DOI Accesso ONLINE all'editore

Pinzauti, Francesca; Pertici, Irene; Reconditi, Massimo; Narayanan, Theyencheri; Stienen, Ger J. M.; Piazzesi, Gabriella; Lombardi, Vincenzo; Linari, Marco; Caremani, Marco* (2018). The force and stiffness of myosin motors in the isometric twitch of a cardiac trabecula and the effect of the extracellular calcium concentration. THE JOURNAL OF PHYSIOLOGY, vol. 596, pp. 2581-2596, ISSN:0022-3751 DOI Accesso ONLINE all'editore

Reconditi, M.; Caremani, M.; Pinzauti, F.; Powers, J.D.; Narayanan, T.; Stienen, G.J.M.; Linari, M.; Lombardi, V.; Piazzesi, G. (2017). Myosin filament activation in the heart is tuned to the mechanical task. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 114, pp. 3240-3245, ISSN:0027-8424 DOI

Fusi, Luca; Percario, Valentina; Brunello, Elisabetta; Caremani, Marco; Bianco, Pasquale; Powers, Joseph D; Reconditi, Massimo; Lombardi, Vincenzo; Piazzesi, Gabriella (2017). Minimum number of myosin motors accounting for shortening velocity under zero load in skeletal muscle. THE JOURNAL OF PHYSIOLOGY, vol. 595, pp. 1127-1142, ISSN:0022-3751 DOI Accesso ONLINE all'editore

Caremani, M.; Pinzauti, F.; Reconditi, M.; Piazzesi, G.; Stienen, G.; Lombardi, V.; Linari, M.; Spudich, J.A. (2016). The size and speed of the working stroke of cardiac myosin in situ.. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 113, pp. 3675-3680, ISSN:1091-6490 DOI Accesso ONLINE all'editore

Caremani, Marco; Melli, Luca; Dolfi, Mario; Lombardi, Vincenzo; Linari, Marco (2015). Force and number of myosin motors during muscle shortening and the coupling with the release of the ATP hydrolysis products. THE JOURNAL OF PHYSIOLOGY, vol. 593, pp. 3313-3332, ISSN:0022-3751 DOI Accesso ONLINE all'editore

M. Linari; E. Brunello; M. Reconditi; L. Fusi; M. Caremani; T. Narayanan; G. Piazzesi; V. Lombardi; M. Irving. (2015). Force generation by skeletal muscle is controlled by mechanosensing in myosin filaments. NATURE, vol. 528, pp. 276-279, ISSN:0028-0836 DOI

Zsolt Martonfalvi; Pasquale Bianco; Marco Linari; Marco Caremani; Attila Nagy; Vincenzo Lombardi; Miklos Kellermayer (2014). Low-force transitions in single titin molecules reflect a memory of contractile history. JOURNAL OF CELL SCIENCE, vol. 127, pp. 858-870, ISSN:0021-9533 DOI Accesso ONLINE all'editore

E. Brunello; M. Caremani; L. Melli; M. Linari; M. Fernandez-Martinez; T. Narayanan; M. Irving; G. Piazzesi; V. Lombardi; M. Reconditi (2014). The contributions of filaments and cross-bridges to sarcomere compliance in skeletal muscle. THE JOURNAL OF PHYSIOLOGY, vol. 592.17, pp. 3881-3899, ISSN:0022-3751 DOI

M. Caremani; L. Melli; M. Dolfi; V. Lombardi; M. Linari (2013). The working stroke of the myosin II motor in muscle is not tightly coupled to release of orthophosphate from its active site.. THE JOURNAL OF PHYSIOLOGY, vol. 591, pp. 5187-5205, ISSN:0022-3751 DOI

M. Caremani; S. Lehman; V. Lombardi; M. Linari (2011). Orthovanadate and orthophosphate inhibit muscle force via two different pathways of the myosin ATPase cycle. BIOPHYSICAL JOURNAL, vol. 100, pp. 665-674, ISSN:0006-3495 DOI

M. Linari; M. Caremani; V. Lombardi (2010). A Kinetic Model that Explains the Effect of Inorganic Phosphate on the Mechanics and Energetics of Isometric Contraction of Fast Skeletal Muscle.. PROCEEDINGS - ROYAL SOCIETY. BIOLOGICAL SCIENCES, vol. 277, pp. 19-27, ISSN:0962-8452 DOI Accesso ONLINE all'editore

M.L. Bang; M. Caremani; E. Brunello; R. Littlefield; R.L. Lieber; J. Chen; V. Lombardi; M. Linari (2009). Nebulin plays a direct role in promoting strong actin-myosin interactions. THE FASEB JOURNAL, vol. 23, pp. 4117-4125, ISSN:0892-6638 DOI Accesso ONLINE all'editore

M. S. Z. KELLERMAYER; P. BIANCO; Z. MARTONFALVI; A. NAGY; A. KENGYEL; D. SZATMARI; T. HUBER; M. LINARI; M. CAREMANI; V. LOMBARDI (2008). Muscle Thixotropy: More than Just Cross-Bridges? Response to Comment by Campbell and Lakie. BIOPHYSICAL JOURNAL, vol. 94, pp. 329-330, ISSN:0006-3495

M.S. Kellermayer; P. Bianco; Z. Martonfalvi; A. Nagy; A. Kengyel; D. Szatmari; T. Huber; M. Linari; M. Caremani; V. Lombardi (2008). Muscle thixotropy: more than just cross-bridges?. BIOPHYSICAL JOURNAL, vol. 94, pp. 329-330, ISSN:0006-3495 DOI Accesso ONLINE all'editore

M. Caremani; J.A. Dantzig; Y.E. Goldman; V. Lombardi; M. Linari (2008). Effect of inorganic phosphate on the force and number of myosin cross-bridges during the isometric contraction of permeabilized muscle fibers from rabbit psoas.. BIOPHYSICAL JOURNAL, vol. 95, pp. 5798-5808, ISSN:0006-3495 DOI Accesso ONLINE all'editore

M. Linari; M. Caremani; C. Piperio; P. Brandt; V. Lombardi (2007). Stiffness and fraction of myosin motors responsible for active force in permeabilized muscle fibers from rabbit psoas. BIOPHYSICAL JOURNAL, vol. 92, pp. 2476-2490, ISSN:0006-3495 DOI Accesso ONLINE all'editore

Marco CAREMANI

Curriculum

Marco Caremani

ORCID 0000-0001-9128-7227

EDUCATION

2008 PhD in Physiological Sciences

Department of Physiology, University of Florence, Italy

Name of PhD Supervisor Marco Linari

2003 Master in Natural Sciences

University of Florence, Italy

CURRENT POSITION(S)

2017 – Resarcher

Department of Biology, University of Florence, Italy

PREVIOUS POSITIONS

2009 – 2017 Postdoc Department of Biology, University of Florence, Italy

2008 – 2009 Postdoc Research Associate, Laboratory of Professor Michael Ferenczi.

National Heart and Lung Institute, Imperial College London

MEMBERSHIPS OF SCIENTIFIC SOCIETIES

2015 – Italian Physiological Society, Italy

2010 – Biophysical Society, USA

RESEARCH INTEREST

My main scientific interest is the study of the molecular mechanisms of contraction of striated (skeletal and cardiac) muscle and its regulation, pursued by integrating single cell mechanics and X-ray diffraction with synchrotron light.