Personale

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Andrea LAPUCCI

Ruolo attuale:: Docente a Contratto

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andrea.lapucci(AT)unifi.it

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0552758393

Andrea LAPUCCI

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Tesi di Dottorato

Molli, Alice; Buonvicino, Daniela; Lapucci, Andrea; Maresca, Luisa; Lanza-Arnaiz, Jose Maria; Polvani, Simone; Cialdai, Francesca; Insero, Giacomo; Mello, Tommaso; Stecca, Barbara; Formentini, Laura; Chiarugi, Alberto (2026). SARM1-dependent antimetabolic cancer therapy. CANCER LETTERS, vol. 658, pp. 0-0, ISSN:0304-3835 DOI

Pistolesi, Alessandra; Tuniz, Simone; Lapucci, Andrea; Molli, Alice; De Cesaris, Francesco; Landini, Lorenzo; Nassini, Romina; Buonvicino, Daniela; Chiarugi, Alberto (2025). Corticosteroid-dependent increased expression of CGRP and its receptor subunits within the rodent trigeminal ganglion does not prompt cephalic allodynia. CEPHALALGIA, vol. 45, pp. 1-11, ISSN:0333-1024 DOI

Ranieri, Giuseppe; Lapucci, Andrea; Orsomando, Giuseppe; Raffaelli, Nadia; Chiarugi, Alberto; Buonvicino, Daniela (2025). Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1. FEBS LETTERS, vol. 599, pp. 3150-3162, ISSN:0014-5793 DOI

Matteo Lulli, Andrea Trabocchi, Giandomenico Roviello, Martina Catalano, Laura Papucci, Astrid Parenti, Alice Molli, Cristina Napoli, Ida Landini, Nicola Schiavone, Andrea Lapucci (2024). Targeting z-Crystallin by aspirin restores the sensitivity to cisplatin in resistant A2780 ovarian cancer cells. FRONTIERS IN PHARMACOLOGY, pp. 0-0, ISSN:1663-9812 DOI

Cecchi M, Anceschi C, Silvano A, Coniglio ML, Chinnici A, Magnelli L, Lapucci A, Laurenzana A, Parenti A. (2024). Unveiling the Role of Tryptophan 2,3-Dioxygenase in the Angiogenic Process. PHARMACEUTICALS, vol. 17(5), pp. 0-0, ISSN:1424-8247 DOI Accesso ONLINE all'editore

Catalano, Martina; Lapucci, Andrea; Nobili, Stefania; De Gennaro Aquino, Irene; Vascotto, Ismaela Anna; Antonuzzo, Lorenzo; Villari, Donata; Nesi, Gabriella; Mini, Enrico; Roviello, Giandomenico (2023). Platinum-based chemotherapy in metastatic prostate cancer: what possibilities?. CANCER CHEMOTHERAPY AND PHARMACOLOGY, pp. 0-0, ISSN:0344-5704 DOI

Maresca, Luisa; Crivaro, Enrica; Migliorini, Francesca; Anichini, Giulia; Giammona, Alessandro; Pepe, Sara; Poggialini, Federica; Vagaggini, Chiara; Giannini, Giuseppe; Sestini, Serena; Borgognoni, Lorenzo; Lapucci, Andrea; Dreassi, Elena; Taddei, Maurizio; Manetti, Fabrizio; Petricci, Elena; Stecca, Barbara (2023). Targeting GLI1 and GLI2 with small molecule inhibitors to suppress GLI-dependent transcription and tumor growth. PHARMACOLOGICAL RESEARCH, pp. 106858-106858, ISSN:1043-6618 DOI

Lulli, Matteo; Napoli, Cristina; Landini, Ida; Mini, Enrico; Lapucci, Andrea (2022). Role of Non-Coding RNAs in Colorectal Cancer: Focus on Long Non-Coding RNAs. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, pp. 13431-13431, ISSN:1422-0067 DOI

Enrico Mini, Ida Landini, Antonello Di Paolo, Gloria Ravegnini, Simona Saponara, Maria Frosini, Andrea Lapucci, Stefania Nobili (2022). Antiangiogenic Drugs as Chemosensitizers in Cancer Therapy. In: Enrico Mini, Ida Landini, Antonello Di Paolo, Gloria Ravegnini, Simona Saponara, Maria Frosini, Andrea Lapucci, Stefania Nobili. Predictive “omic” biomarkers of drug response: Colorectal cancer as a model, pp. 199-240 Elsevier.

Marta Cecchi , Antonella Mannini , Andrea Lapucci , Angela Silvano, Matteo Lulli , Cristina Luceri , Mario D’Ambrosio, Alberto Chiarugi , Ali H. Eid , Astrid Parenti (2022). Dexamethasone promotes a stem-like phenotype in human melanoma cells via tryptophan 2,3 dioxygenase. FRONTIERS IN PHARMACOLOGY, vol. 13, pp. 1-12, ISSN:1663-9812 DOI Accesso ONLINE all'editore

Lapucci, Andrea; Perrone, Gabriele; Di Paolo, Antonello; Napoli, Cristina; Landini, Ida; Roviello, Giandomenico; Calosi, Laura; Naccarato, Antonio Giuseppe; Falcone, Alfredo; Bani, Daniele; Mini, Enrico; Nobili, Stefania (2021). PNN and KCNQ1OT1 can predict the efficacy of adjuvant fluoropyrimidine-based chemotherapy in colorectal cancer patients. ONCOLOGY RESEARCH, vol. 28, pp. 631-644, ISSN:0965-0407 DOI

Buonvicino D.; Ranieri G.; Pittelli M.; Lapucci A.; Bragliola S.; Chiarugi A. (2021). SIRT1-dependent restoration of NAD+ homeostasis after increased extracellular NAD+ exposure. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 297, pp. 100855-100855, ISSN:0021-9258 DOI

Nobili, Stefania; Mannini, Antonella; Parenti, Astrid; Raggi, Chiara; Lapucci, Andrea; Chiorino, Giovanna; Paccosi, Sara; Di Gennaro, Paola; Vezzosi, Vania; Romagnoli, Paolo; Susini, Tommaso; Coronnello, Marcella (2021). Establishment and characterization of a new spontaneously immortalized ER-/PR-/HER2+ human breast cancer cell line, DHSF-BR16. SCIENTIFIC REPORTS, vol. 11, pp. 8340-8354, ISSN:2045-2322 DOI Accesso ONLINE all'editore

Nobili S, Lapucci A, Landini I, Coronnello M, Roviello G, Mini E. (2020). Role of ATP-binding cassette transporters in cancer initiation and progression. SEMINARS IN CANCER BIOLOGY, pp. 72-95, ISSN:1044-579X DOI

Teodori E.; Braconi L.; Bua S.; Lapucci A.; Bartolucci G.; Manetti D.; Romanelli M.N.; Dei S.; Supuran C.T.; Coronnello M. (2020). Dual P-glycoprotein and CA XII inhibitors: A new strategy to reverse the P-gp Mediated Multidrug Resistance (MDR) in cancer cells y. MOLECULES, vol. 25, pp. 1-26, ISSN:1420-3049 DOI Accesso ONLINE all'editore

Mini E.; Lapucci A.; Perrone G.; D'Aurizio R.; Napoli C.; Brugia M.; Landini I.; Tassi R.; Picariello L.; Simi L.; Mancini I.; Messerini L.; Magi A.; Pinzani P.; Mazzei T.; Tonelli F.; Nobili S. (2019). RNA sequencing reveals PNN and KCNQ1OT1 as predictive biomarkers of clinical outcome in stage III colorectal cancer patients treated with adjuvant chemotherapy. INTERNATIONAL JOURNAL OF CANCER, pp. 0-0, ISSN:0020-7136, Wiley-Liss Inc.: DOI Accesso ONLINE all'editore

Mini, Enrico; Landini, Ida; Lucarini, Laura; Lapucci, Andrea; Napoli, Cristina; Perrone, Gabriele; Tassi, Renato; Masini, Emanuela; Moroni, Flavio; Nobili, Stefania (2018). Erratum: The inhibitory effects of HYDAMTIQ, a novel PARP inhibitor, on growth in human tumor cell lines with defective DNA damage response pathways (Oncology Research 25:9 (1441-1451) DOI: 10.3727/096504017X14926854178616). ONCOLOGY RESEARCH, vol. 26, pp. 333-334, ISSN:0965-0407 DOI Accesso ONLINE all'editore

Buonvicino, Daniela*; Felici, Roberta; Ranieri, Giuseppe; Caramelli, Riccardo; Lapucci, Andrea; Cavone, Leonardo; Muzzi, Mirko; Di Pietro, Lorena; Bernardini, Camilla; Zwergel, Clemens; Valente, Sergio; Mai, Antonello; Chiarugi, Alberto (2018). Effects of Class II-Selective Histone Deacetylase Inhibitor on Neuromuscular Function and Disease Progression in SOD1-ALS Mice. NEUROSCIENCE, vol. 379, pp. 228-238, ISSN:0306-4522 DOI Accesso ONLINE all'editore

Buonvicino D.; Urru M.; Muzzi M.; Ranieri G.; Luceri C.; Oteri C.; Lapucci A.; Chiarugi A. (2018). Trigeminal ganglion transcriptome analysis in 2 rat models of medication-overuse headache reveals coherent and widespread induction of pronociceptive gene expression patterns. PAIN, vol. 159, pp. 1980-1988, ISSN:0304-3959 DOI Accesso ONLINE all'editore

Landini, I; Lapucci, A; Pratesi, A; Massai, L; Napoli, C; Perrone, G; Pinzani, P; Messori, L; Mini, E; Nobili, S. (2017). Selection and characterization of a human ovarian cancer cell line resistant to auranofin. ONCOTARGET, vol. 8, pp. 96062-96078, ISSN:1949-2553

Di Cesare Mannelli, L; Tenci, B; Micheli, L; Vona, A; Corti, F; Zanardelli, M; Lapucci, A; Clemente, Am; Failli, P; Ghelardini, C. (2017). Adipose-derived stem cells decrease pain in a rat model of oxaliplatin-induced neuropathy: Role of VEGF-A modulation. NEUROPHARMACOLOGY, pp. 166-175, ISSN:1873-7064 DOI

Maggini V, Gallo E, Landini I, Lapucci A, Nobili S, Mini E, Firenzuoli F (2017). P118 A preliminary study for evaluation of cannabis - chemotherapy interactions on human colon cancer cells. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, vol. 17, pp. 115-115, ISSN:1472-6882 DOI

Mini, E; Landini, I; Lucarini, L; Lapucci, A; Napoli, C; Perrone, G; Tassi, R; Masini, E; Moroni, F; Nobili, S. (2017). The Inhibitory Effects of HYDAMTIQ, a Novel PARP Inhibitor, on Growth in Human Tumor Cell Lines With Defective DNA Damage Response Pathways.. ONCOLOGY RESEARCH, vol. 25, pp. 1441-1451, ISSN:0965-0407 DOI

Felici, Roberta; Buonvicino, Daniela; Muzzi, Mirko; Cavone, Leonardo; Guasti, Daniele; Lapucci, Andrea; Pratesi, Sara; De Cesaris, Francesco; Luceri, Francesca; Chiarugi, Alberto (2017). Post onset, oral rapamycin treatment delays development of mitochondrial encephalopathy only at supramaximal doses. NEUROPHARMACOLOGY, vol. 117, pp. 74-84, ISSN:0028-3908 DOI Accesso ONLINE all'editore

Lapucci, Andrea; Cavone, Leonardo; Buonvicino, Daniela; Felici, Roberta; Gerace, Elisabetta; Zwergel, Clemens; Valente, Sergio; Mai, Antonello; Chiarugi, Alberto (2017). Effect of Class II HDAC inhibition on glutamate transporter expression and survival in SOD1-ALS mice. NEUROSCIENCE LETTERS, vol. 656, pp. 120-125, ISSN:0304-3940 DOI Accesso ONLINE all'editore

Tassi, R.; Mini, E.; D'Aurizio, R.; Perrone, G.; Magi, A.; Lapucci, A.; Napoli, C.; Picariello, L.; Brugia, M.; Landini, I.; Mazzei, T.; Tonelli, F.; Nobili, S. (2016). D13Global gene expression profile reveals a distinct transcriptomic profile predictive of clinical outcome in stage III colorectal cancer patients treated with adjuvant chemotherapy. ANNALS OF ONCOLOGY, vol. 27, pp. iv43-iv43, ISSN:0923-7534 DOI

Mini, E.; D’ Aurizio, R.; Perrone, G.; Magi, A.; Lapucci, A.; Tassi, R.; Napoli, C.; Picariello, L.; Landini, I.; Nobili, S. (2016). RNA sequencing reveals a distinct transcriptomic profile predictive of clinical outcome in stage III colorectal cancer patients treated with adjuvant chemotherapy. EUROPEAN JOURNAL OF CANCER, vol. 61, pp. S199-S199, ISSN:0959-8049 DOI

Mini, E; Landini, I; Napoli, C; Nobili, S; Perrone, G; Lapucci, A (2016). Pharmacological modulation of protein kinase C for overcoming drug resistance in colorectal cancer. Preliminary results of in vitro studies.. ANNALS OF ONCOLOGY, vol. 27, pp. 45-45, ISSN:0923-7534 DOI

Dilaghi, Arianna; Occupati, Brunella; Lapucci, Andrea; Masini, Emanuela; Mannaioni, Guido (2016). High-dose methadone: Management of an opioid-addicted patient. HEROIN ADDICTION AND RELATED CLINICAL PROBLEMS, vol. 18, pp. 25-30, ISSN:1592-1638 Accesso ONLINE all'editore

Tassi, R; Mini, E; D'Aurizio, R; Perrone, G; Magi, A; Lapucci, A; Napoli, C; Picariello, L; Brugia, M; Landini, I; Mazzei, T; Tonelli, F; Nobili, S (2016). Global gene expression profile reveals a distinct transcriptomic profile predictive of clinical outcome in stage III colorectal cancer patients treated with adjuvant chemotherapy. ANNALS OF ONCOLOGY, vol. 27, pp. 43-43, ISSN:0923-7534 DOI

Lulli, M.; Loffredo, R.; Lapucci, A.; Papucci, L.; Capaccioli, S.; Schiavone, N. (2016). Involvement of ζ-Crystallin in Acidic Microenvironment of Melanoma. THE AMERICAN JOURNAL OF PATHOLOGY, vol. 186, pp. 0-0, ISSN:0002-9440

Mini, E; D’Aurizio, R; Perrone, G; Magi, A; Lapucci, A; Tassi, R; Napoli, C; Picariello, L; Landini, I; Brugia, M; Mazzei, T; Tonelli, F; Nobili, S (2016). A transcriptomic profile predicts clinical outcome in stage III colorectal cancer patients treated with adjuvant chemotherapy. ANNALS OF ONCOLOGY, vol. 27, pp. 575-575, ISSN:0923-7534 DOI

Cavone, L; Felici, R; Lapucci, A; Buonvicino, D; Pratesi, S; Muzzi, M; Hakiki, B; Maggi, L; Peruzzi, B; Caporale, R; Annunziato, F; Amato, Mp; Chiarugi, A. (2015). Dysregulation of sphingosine 1 phosphate receptor-1 (S1P1) signaling and regulatory lymphocyte-dependent immunosuppression in a model of post-fingolimod MS rebound.. BRAIN BEHAVIOR AND IMMUNITY, pp. 1-9, ISSN:0889-1591

Felici, Roberta; Lapucci, Andrea; Cavone, Leonardo; Pratesi, Sara; Berlinguer-Palmini, Rolando; Chiarugi, Alberto (2015). Pharmacological NAD-boosting strategies improve mitochondrial homeostasis in human complex i-mutant fibroblastss. MOLECULAR PHARMACOLOGY, vol. 87, pp. 965-971, ISSN:0026-895X DOI Accesso ONLINE all'editore

Mencucci, Rita; Favuzza, Eleonora; Boccalini, Carlotta; Lapucci, Andrea; Felici, Roberta; Resta, Francesco; Chiarugi, Alberto; Cavone, Leonardo (2014). CoQ10-containing eye drops prevent UVB-induced cornea cell damage and increase cornea wound healing by preserving mitochondrial function. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 55, pp. 7266-7271, ISSN:0146-0404 DOI Accesso ONLINE all'editore

Rosa Loffredo; Matteo Lulli; Ewa Witort; Irene Granucci; Federico Di Gesualdo; Andrea Lapucci; Amedeo Amedei; Sergio Capaccioli (2014). Impact of acidosis on ζ-crystallin-mediated bcl-2 expression in leukemic cell lines. FRONTIERS IN PHARMACOLOGY, pp. 0-0, ISSN:1663-9812 DOI

Felici R; Cavone L; Lapucci A; Guasti D; Bani D; Chiarugi A (2014). PARP inhibition delays progression of mitochondrial encephalopathy in mice. NEUROTHERAPEUTICS, vol. 11, pp. 651-664, ISSN:1933-7213 DOI

Felici R; Lapucci A; Ramazzotti M; Chiarugi A. (2013). Insight into molecular and functional properties of NMNAT3 reveals new hints of NAD homeostasis within human mitochondria. PLOS ONE, pp. 76938-76942, ISSN:1932-6203

A. Lapucci; M. Pittelli; E. Rapizzi; R. Felici; F. Moroni; A. Chiarugi (2011). Poly(ADP-ribose) polymerase-1 is a nuclear epigenetic regulator of mitochondrial DNA repair and transcription. MOLECULAR PHARMACOLOGY, vol. 79, pp. 932-940, ISSN:0026-895X DOI

M. Pittelli; L. Formentini; G. Faraco; A. Lapucci; E. Rapizzi; F. Cialdai; G. Romano; G. Moneti; F. Moroni; A. Chiarugi (2010). Inhibition of nicotinamide phosphoribosyltransferase: cellular bioenergetics reveals a mitochondrial insensitive NAD pool. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, pp. 34106-34114, ISSN:1067-8816 DOI Accesso ONLINE all'editore

F.Margheri; S.Serrati; A.Lapucci; A.Chilla; L.Bazzichi ; S.Bombardieri; B.Kahaleh ; L.Calorini ; F.Bianchini; G.Fibbi; M.Del Rosso M (2010). Modulation of the angiogenic phenotype of normal and systemic sclerosis endothelial cells by gain-loss of function of pentraxin 3 and matrix metalloproteinase 12. ARTHRITIS AND RHEUMATISM, vol. 62, pp. 2488-2498, ISSN:0004-3591 DOI Accesso ONLINE all'editore

A.Lapucci; M.Lulli; A.Amedei; L.Papucci; E.Witort; F.Di Gesualdo; F.Bertolini; G.Brewer; A.Nicolin; A.Bevilacqua; N.Schiavone; D.Morello; M.Donnini; S.Capaccioli (2010). ζ-Crystallin is a bcl-2 mRNA binding protein involved in bcl-2 over-expression in T-cell Acute Lymphocytic Leukemia. THE FASEB JOURNAL, vol. 24, pp. 1852-1865, ISSN:0892-6638 DOI Accesso ONLINE all'editore

Margheri F; Serratì S; Lapucci A; Anastasia C; Giusti B; Pucci M; Torre E; Bianchini F; Calorini L; Albini A; Ventura A; Fibbi G; Del Rosso M. (2009). Systemic sclerosis-endothelial cell antiangiogenic pentraxin 3 and matrix metalloprotease 12 control human breast cancer tumor vascularization and development in mice.. NEOPLASIA, vol. 11, pp. 1106-1115, ISSN:1522-8002 DOI Accesso ONLINE all'editore

Di Gesualdo F; Donnini M; Witort E; Papucci L; Specogna R; Cianchi F; Lulli M; Capaccioli S; Lapucci A. (2009). Role of ζ-Crystallin and Other AUBPs in Bcl-2 Over-Expression Occurring in B-cell CLLs.. In: Annual Meeting at Experimental Biology, New Orleans, 18-22 Aprile, pp. 1-1.

Di Gesualdo, F; Donnini, M; Witort, E; Papucci, L; Specogna, R; Cianchi, F; Lulli, M; Capaccioli, S; Lapucci, A (2009). Role of ζ-Crystallin and Other AUBPs in Bcl-2 Over-Expression Occurring in B-cell CLLs.. THE FASEB JOURNAL, vol. 23, pp. 0-0, ISSN:0892-6638

Lulli, M; Donnini, M; Lapucci, A; Quaglierini, P; Witort, E; Papucci, L; Specogna, R; Morello, D; Capaccioli, S (2009). Evolutionary conservation of Tino/Quaking interaction suggests its impact to cell polarity control in ontogenesis and oncogenesis. THE FASEB JOURNAL, vol. 23, pp. 0-0, ISSN:0892-6638

Capaccioli, S; Papucci, L; Witort, E; Lapucci, A; Quaglierini, P; Specogna, R; Lulli, M; Donnini, M (2009). Shedding a new light on the circuit HIF-1 alfa/CA IX/uPAR and other neovascularization related genes by means of post-transcriptional gene modulators in proliferative retinopathies.. THE FASEB JOURNAL, vol. 23, pp. 0-0, ISSN:0892-6638

Donnini M; Lulli M; Lapucci A; Witort E; Papucci L; Brocchi S; Nicolin A; Cianchi F; Specogna R; Quaglierini P; Schiavone N; Morello D; Capaccioli S (2008). L’analisi bioinformatica degli MRNA legati dalla RNA-binding protein TINO/HMEX-3D rivela lesistenza di un circuito di controllo post-trascrizional, conservato evolutivamente, tra TINO-MEX3 e Quaking/GLD1.. In: Convegno Annuale Associazione Italiana di Colture Cellulari, Bologna, 26-28 Novembre, pp. 1-1.

Papucci L.; Capaccioli S.; Cianchi F.; Schiavone N.; Lulli M.; Donnini M.; Lapucci A.; Magnelli L.; Masini E. (2008). Cannabinoid receptor activation commits colon cancer cells to apoptosis via tumor necrosis factor α-induced ceramide synthesis.. THE AMERICAN JOURNAL OF PATHOLOGY, vol. 173, pp. S22-S22, ISSN:0002-9440

S. lazzarano; M. Lulli; G. Fibbi; F. Margheri; L. Papucci; S. Serratì; E. Witort; A. Chillà; A. Lapucci; M. Donnini; P. Quaglierini; A. Romiti; R. Specogna; M. Del Rosso; S. Capaccioli (2008). Anti-urokinase receptor antisense oligonucleotide (uPar-aODN) to prevent and cure long-term space exploration related retinal pathological angiogenesis. JOURNAL OF GRAVITATIONAL PHYSIOLOGY, vol. 15, pp. 225-226, ISSN:1077-9248

A Lapucci; S Capaccioli; M Lulli; M Donnini; N Schiavone; A Amedei; E Witort; L Papucci; S Lazzarano; G Brewer; D Morello (2008). Bcl-2 Over-Expression in Human T-Cell Acute LymphocyticLeukemias is Consequent to mRNA Stabilization by Increased Binding to Zeta-Crystallin, a New Bcl-2 ARE-Binding Protein. THE AMERICAN JOURNAL OF PATHOLOGY, vol. 173, pp. S22-S22, ISSN:0002-9440 Accesso ONLINE all'editore

Capaccioli S; Lapucci A; Lulli M; Amedei A; Donnini M; Papucci L; Witort E; Lazzarano S; Conti S; Specogna R; Brewer G; Nicolin A; Morello D; Schiavone N (2008). Z-crystallin is a new stabilizing bcl-2 mRNA au-rich element binding protein overexpressed in the acute lymphocytic leukemia Jurkat T-CELL line. CELLULAR ONCOLOGY, vol. 30, pp. 190-190, ISSN:1570-5870

M Donnini; S Capaccioli; M Lulli; A Lapucci; L Papucci; S Lazzarano; E Witort; A Nicolin; N Schiavone; D Morello (2008). Evidence of a Conserved Regulatory Circuit Between Mex-3 andGLD-1 Through Analysis of Tino/hMEX-3D Binding Sequence. THE AMERICAN JOURNAL OF PATHOLOGY, vol. 173, pp. S14-S14, ISSN:0002-9440 Accesso ONLINE all'editore

Papucci L; Witort E; Schiavone N; Donnini M; Lapucci A; Lulli M; Lazzarano S; Simoncini M; Mazzoni T; Falciani P; Capaccioli S (2008). Topical administration of the mithocondrial PTP opening inhibitor CoQ10 prevents apoptotic cell death induced by UVC-irradiation in rat's corneas and rabbit's retinas.. In: Life in Space for Life on Earth, Angers, France, 22 June 2008through27 July 2008, vol. 15, pp. 311-312, ISBN:9789292212278

L.Papucci; E.Witort; A.M.Bevilacqua; M.Donnini; M.Lulli; E.Borchi; K.S.A.Khabar; A.Tempestini; A.Lapucci; N.Schiavone; A.Nicolin; S.Capaccioli (2008). Impact of Targeting the Adenine- and Uracil-Rich Element of bcl-2 mRNA with Oligoribonucleotides on Apoptosis, Cell Cycle, and Neuronal Differentiation in SHSY-5Y Cells. MOLECULAR PHARMACOLOGY, vol. 73, pp. 498-508, ISSN:0026-895X DOI Accesso ONLINE all'editore

Papucci, L; Witort, E; Schiavone, N; Donnini, M; Lapucci, A; Lulli, M; Lazzarano, S; Simoncini, M; Mazzoni, T; Falciani, Pg; Capaccioli, S (2008). Topical administration of the mitochondrial PTP opening inhibitor COQ10 prevents apoptotic cell death induced by UVC-irradiation in rat corneas and rabbit retinas.. JOURNAL OF GRAVITATIONAL PHYSIOLOGY, vol. 15, pp. 311-312, ISSN:1077-9248

L Papucci; S Capaccioli; F Cianchi; N Schiavone; M Lulli; M Donnini; A Lapucci; L Magnelli; E Masini (2008). Cannabinoid Receptor Activation Commits Colon Cancer Cells toApoptosis Via Tumor Necrosis Factor A-Induced Ceramide Synthesis. THE AMERICAN JOURNAL OF PATHOLOGY, vol. 173, pp. S22-S22, ISSN:0002-9440 Accesso ONLINE all'editore

Witort EJ; Pattarino J; Papucci L; Schiavone N; Donnini M; Lapucci A; Lulli M; Lo Russo G; Mori A; Dini M; Capaccioli S (2007). Autologous lipofilling: Coenzyme Q(10) can rescue adipocytes from stress-induced apoptotic death.. In: 9th International Congress of Italian and American Plastic Surgeons, New Orleans, LA., SEP 20, 2004, LIPPINCOTT WILLIAMS & WILKINS, vol. 119, pp. 1191-1199. DOI

Witort, EWA JANINA; Pattarino, Jacopo; Papucci, Laura; Schiavone, Nicola; Donnini, Martino; Lapucci, Andrea; Lulli, Matteo; LO RUSSO, Giulia; Mori, Andrea; Dini, Mario; Capaccioli, Sergio (2007). Autologous lipofilling: coenzyme Q10 can rescue adipocytes from stress-induced apoptotic death. PLASTIC AND RECONSTRUCTIVE SURGERY, vol. 119, pp. 1191-1199, ISSN:0032-1052, Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320: DOI

A. TEMPESTINI; B. CACIAGLI; M. MORGANTI; E. WITORT; S. NOBILI; L. PAPUCCI; N. SCHIAVONE; M. DONNINI; I. LANDINI; A. LAPUCCI; F. PERNA; M. LULLI; T. MAZZEI; A. SOBRERO; E. MINI; S. CAPACCIOLI (2006). MOLECULAR CHARACTERIZATION OF ESTABLISHED HUMAN COLON CARCINOMA CELL LINES (HCT-8) MADE RESISTANT TO 5-FLUOROURACIL BY DIFFERENT SELECTION SCHEDULES. ONCOLOGY RESEARCH, vol. 16, pp. 143-156, ISSN:0965-0407, Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010:

Perna F; Perigli G; Masini E; Capaccioli S; Schiavone N; Lulli M; Lapucci A; Cianchi F. (2006). Inhibitors of the cyclooxygenase-2 and 5-lipoxygenase pathways have superadditive effects on inducing apoptosis and reducing cell growth in human colon cancer. In: UICC-World Cancer Congress, Washington, USA, 8-12 Luglio, pp. 492-492.

M.Dini; J.Pattarino; A.Mori; G.Lo Russo; L.Papucci; E.Witort; N.Schiavone; M.Donnini; A.Lapucci; S.Capaccioli (2005). Prevention of apoptosis of adipocytes collected for lipofilling by treatment with Coenzyme Q10. In: 10th Congress ESPRAS, Vienna, 30 agosto-3 settembre 2005, pp. 26-26. Accesso ONLINE all'editore

L.Ghisolfi; L.Papucci; A.Bevilacqua; G.Canti; G.Tataranni; A.Lapucci; N.Schiavone; S.Capaccioli; A.Nicolin (2005). Increased Bcl2 expression by antisense oligoribonucleotides targeting the adenine-uridine-rich element motif.. MOLECULAR PHARMACOLOGY, vol. 68, pp. 816-821, ISSN:0026-895X DOI Accesso ONLINE all'editore

Capaccioli S; Nucci C; Lapucci A; Schiavone N; Virgili G; Cerulli L; Brancato R; Carella G (2005). Apoptosis and Myopia In: "Myopia and Related Diseases, Autori vari". In: Autori Vari. Myopia and Related Diseases, pp. 66-83, New York: Ophthalmic Communications Society, Inc..

Capaccioli S.; Witort E.; Lo Russo D.; Papucci L.; Schiavone N.; Lapucci A.; Donnini M.; Dini M; Pattarino J. (2005). “Coenzyme Q10 as antiapoptotic agent”. Numero: EP1516618A1 VISUFARMA S.R.L

M.Donnini; A.Lapucci; L.Papucci; E.Witort; A.Jacquier; G.Brewer; A.Nicolin; S.Capaccioli; N.Schiavone (2004). Identification of Tino: a new evolutionarily conserved bcl-2 AU-rich element RNA binding protein. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, pp. 20154-20166, ISSN:0021-9258 DOI Accesso ONLINE all'editore

S. Capaccioli; E. Witort; D. Lo Russo; N. Schiamone; A. Lapucci; M. Donnini; M. Dini; J. Pattarino. (2004). “Coenzyme Q10 as antiapoptotic agent”. Numero: 04021895.0 S. Capaccioli, E. Witort, D. Lo Russo, N. Schiamone, A. Lapucci, M. Donnini, M. Dini, J. Pattarino

E.Witort; M.Dini; J.Pattarino; L.Papucci; N.Schiavone; M.Donnini; A.Lapucci; G.Lo Russo; D.Lo Russo; S.Capaccioli (2004). Prevenzione dell’apoptosi mediante coenzima Q10 in adipociti umani prelevati ai fini del lipofilling. In: 53° Congresso Nazionale della Società Italiana di Chirurgia Plastica Ricostruttiva ed Estetica, Pisa, 16-18 Settembre 2004, ...., pp. 22-22.

A. Tempestini; E. Witort; L. Papucci; N. Schiavone; M. Donnini; A. Lapucci; F. Perna; M. Morganti; B. Caciagli; I. Landini; A. Sobrero; E. Mini; S. Capaccioli (2004). Molecular characterization of established human colorectal carcinoma cell lines (HCT-8) made resistant to 5-fluorouracil (5-FU) by different selective schedules. JOURNAL OF CHEMOTHERAPY, vol. 16 (Suppl 1), pp. 177-177, ISSN:1120-009X DOI

Papucci L; Formigli L; Schiavone N; Tani A; Donnini M; Lapucci A; Perna F; Tempestini A; Witort E; Morganti M; Nosi D; Orlandini GE; Orlandini SZ; Capaccioli S (2004). Apoptosis shifts to necrosis via intermediate types of cell death by a mechanism depending on c-myc and bcl-2 expression. CELL AND TISSUE RESEARCH, vol. 316, pp. 197-209, ISSN:0302-766X DOI Accesso ONLINE all'editore

E.Witort; M.Dini; J.Pattarino; G.Lo Russo; L.Papucci; N.Schiavone; M.Donnini; A.Lapucci; D.Lo Russo; S.Capaccioli (2004). Coenzyme Q10 prevents adipocyte apoptosis following collection for lipofilling. RIVISTA ITALIANA DI CHIRURGIA PLASTICA, vol. 36, pp. 67-70, ISSN:0391-2221

S. CAPACCIOLI; N. SCHIAVONE; M. DONNINI; A. LAPUCCI; F. PERNA; M. LULLI; L. PAPUCCI; E. BORCHI (2004). IL COENZIMA Q10 INIBISCE L'APOPTOSI IN CELLULE CORNEALI E RETINICHE INDIPENDENTEMENTE DAL SUO RUOLO DI MOLECOLA ANTIOSSIDANTE. In: Autori vari. QUADERNI DI OFTALMOLOGIA - NEUROPROTEZIONE NELLA TERAPIA DEL GLAUCOMA, pp. 112-119, Roma: EDITORE: SOCIETÀ OFTALMOLOGICA ITALIANA.

E. Witort; M. Dini; J. Pattarino; L. Papucci; N. Schiavone; M. Donnini; A. Lapucci; G. Lo Russo; D. Lo Russo; S. Capaccioli (2003). Il Coenzima Q10 protegge dall’apoptosi gli adipociti prelevati ai fini del Lipofilling. In: 52o Congresso Nazionale SICPRE, Firenze, 18-20 Settembre 2003, pp. 218-218.

Carella G; Tempestini A; Papucci L; Schiavone N; Donnini M; Lapucci A; Witort E; Brancato R; Capaccioli S (2003). Prevention of retinal cell apoptosis by antisense modified oligoribonucleotides that upregulate Bcl-2 expression by targeting a Bcl-2 mRNA destablilizing element (ARE). In: Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, FT LAUDERDALE, FLORIDA, MAY , 2003, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, vol. 44, pp. 405-405.

E.Witort; M.Dini; J.Pattarino; L.Papucci; N.Schiavone; M.Donnini; A.Lapucci; G.Lo Russo; D.Lo Russo; S.Capaccioli (2003). Il Coenzima Q10 protegge dall’apoptosi gli adipociti prelevati ai fini del Lipofilling.. In: 52° Congresso Nazionale SICPRE, Firenze, 18-20 Settembre 2003., pp. 15-15.

L. PAPUCCI; N. SCHIAVONE ; E. WITORT;M. DONNINI ;A. LAPUCCI ; A. TEMPESTINI ; L. FORMIGLI; S. ZECCHI-ORLANDINI ; G.E ORLANDINI ; G. CARELLA G; R. BRANCATO ; S. CAPACCIOLI (2003). Coenzyme q10 prevents apoptosis by inhibiting mitochondrial depolarization independently of its free radical scavenging property.. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, pp. 28220-28228, ISSN:0021-9258, American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824: DOI Accesso ONLINE all'editore

Capaccioli S.; Papucci L.; Schiavone N.; Donnini M.; Lapucci A.; Tempestini A.; Brancato R. (2003). “Antisense Oligonucleotides Modulating BCL-2 Expression”. Numero: W0 03/040182A1 Capaccioli S., Papucci L., Schiavone N., Donnini M. Lapucci A., Tempestini A., Brancato R.

LUZI E.; PAPUCCI L.; N. SCHIAVONE; DONNINI M.; LAPUCCI A.; TEMPESTINI A.; WITORT E.; NICOLIN A.; CAPACCIOLI S. (2003). Downregulation of bcl-2 expression in lymphoma cells by bcl-2 ARE-targeted modified, synthetic ribozyme.. CANCER GENE THERAPY, vol. 10, pp. 201-208, ISSN:0929-1903, Nature Publishing Group:Brunel Road Houndmills, Basingstoke RG21 6XS United Kingdom:011 44 20 78334000, EMAIL: institutions@natureny.com, INTERNET: http://www.nature.com, Fax: 011 44 20 78434640: DOI Accesso ONLINE all'editore

Papucci L; Witort E; Donnini M; Lapucci A; Tempestini A; Cianchi F; Schiavone N; Capaccioli S. (2002). Clonal expansion of C-Myc overexpressing cells is associated with gene mutations enhancing the apoptotic threshold.. In: XXIX Symposium of the Italian Cancer Society, Genova, 27-30 Ottobre, pp. 95-95.

L. PAPUCCI;N. SCHIAVONE; M. DONNINI; A. LAPUCCI; E. LUZI; A. TEMPESTINI; E. WITORT; S. CAPACCIOLI (2002). PHOSPHODIESTER OLIGONUCLEOTIDES INHIBIT MITOSIS AND TRIGGER APOPTOSIS BY A NON-ANTISENSE, P53-MEDIATED MECHANISM.. ANTISENSE AND NUCLEIC ACID DRUG DEVELOPMENT, vol. 12, pp. 21-31, ISSN:1087-2906 DOI Accesso ONLINE all'editore

Tempestini A; Schiavone N; Papucci L; Witort E; Lapucci A; Cutrì M; Donnini M; Capaccioli S (2002). The mechanisms of apoptosis in biology and medicine: a new focus for ophthalmology. In: International Workshop on Apoptosis and Neuroprotection in Ophthalmology: From Basic Research to new Therapeutic Strategies for Eye Disease, UNIV ROME, ROME, ITALY, FEB 15, 2002, WICHTIG EDITORE, vol. 13, pp. 11-18.

A.Lapucci; M.Donnini; L.Papucci; E.Witort; A.Tempestini; A.Nicolin; G.Brewer; N.Schiavone; S.Capaccioli (2002). AUF1 ia a bcl-2 ARE-binding protein involved in bcl-2 mRNA destabilization during apoptosis. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, pp. 16139-16146, ISSN:0021-9258 DOI

R. BRANCATO ;T. FIORE ;L. PAPUCCI ; N. SCHIAVONE ; L. FORMIGLI; S. ZECCHI-ORLANDINI ; P.G GOBBI; F. CARONESI; M. DONNINI; A. LAPUCCI; S. CAPACCIOLI. (2002). Concomitant effect of topical ubiquinone Q10 and vitamin E to prevent keratocyte apoptosis after excimer laser photoablation in rabbits.. JOURNAL OF REFRACTIVE SURGERY, vol. 18, pp. 135-139, ISSN:1081-597X, Slack Incorporated:6900 Grove Road:Thorofare, NJ 08086:(800)257-8290, (856)848-1000, EMAIL: customerservice@slackinc.com, INTERNET: http://www.slackinc.com, Fax: (856)853-5991:

Brancato R; Papucci L; Lapucci A; Donnini M; Schiavone N; Witort E; Formigli L; Orlandini SZ; Carella G; Capaccioli S (2001). Ubiquinone Q10 counteracts apoptotic signals unrelated to free radical production in cultured keratocytes. In: Ophthalmology, 15 marzo 2001, vol. 42, pp. 904-904.

Donnini M.; Lapucci A.; Papucci L.; Witort E.; Tempestini A.; Brewer G.; Bevilacqua A.; Nicolin A.; Capaccioli S.; Schiavone N. (2001). Apoptosis is associated with early modifications of bcl-2 mRNA AU-binding proteins.. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 287, pp. 1063-1069, ISSN:0006-291X DOI Accesso ONLINE all'editore

N.SCHIAVONE;L.PAPUCCI;A.LAPUCCI;P.LUCIANI;S.CAPACCIOLI; M.DONNINI (2000). INDUCTION OF APOPTOSIS AND MITOSIS INHIBITION BY DEGRADED DNA LIPOTRANSFECTION MIMICKING GENOTOXIC DRUG EFFECTS. BIOCHEM BIOPHYS RES COMMUN. 2000 APR 13;270(2):406-14. PMID: 10753638 [PUBMED - INDEXED FOR MEDLINE]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 270, pp. 406-414, ISSN:0006-291X

Brancato R; Capaccioli S; Schiavone N; Siano S; Donnini M; Lapucci A; Papucci L; Orlandini SZ; Carella G; Carones F (2000). Excimer laser-induced cultured keratocyte apoptosis is inhibited by ubiquinone Q-10. In: ophthalmology, 15 marzo 2000, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, vol. 41, pp. 460-460.

R. Brancato; N. Schiavone; S. Siano; A. Lapucci; L. Papucci; M. Donnini; L. Formigli; S. Zecchi Orlandini; G. Carella; F. Carones; S. Capaccioli (2000). Prevention of corneal keratocyte apoptosis after argon fluoride excimer laser irradiation with the free radical scavenger ubiquinone Q10.. EUROPEAN JOURNAL OF OPHTHALMOLOGY, vol. 10, pp. 32-38, ISSN:1120-6721

Carella G; Capaccioli S; Brancato R; Donnini M; Lapucci A; Papucci L; Schiavone N; Cutri M; Formigli L; Orlandini SZ (2000). Cultured corneal keratocyte apoptosis induced by UV radiation is prevented by ubiquinone Q-10. In: Ophthalmology, 15 marzo 2000, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, vol. 41, pp. 697-697.

R.BRANCATO; N.SCHIAVONE; S.SIANO; A.LAPUCCI; L.PAPUCCI; M.DONNINI; L.FORMIGLI; SZ.ORLANDINI; G.CARELLA; F.CARONES; S.CAPACCIOLI (2000). Prevention of corneal keratocyte apoptosis after argon fluoride excimer laser irradiation with the free radical scavenger ubiquinone Q10.. EUROPEAN JOURNAL OF OPHTHALMOLOGY, vol. 10, pp. 32-38, ISSN:1120-6721

N.SCHIAVONE; P.ROSINI; A.QUATTRONE; M.DONNINI; A.LAPUCCI; L.CITTI; A.BEVILACQUA; A.NICOLIN; S.CAPACCIOLI (2000). A conserved AU-rich element in the 3' untranslated region of bcl-2 mRNA is endowed with a destabilizing function that is involved in bcl-2 down-regulation during apoptosis.. THE FASEB JOURNAL, vol. 14, pp. 174-184, ISSN:0892-6638 Accesso ONLINE all'editore

Andrea LAPUCCI

Curriculum

Andrea Lapucci PhD

Curriculum Vitae

1998: Degree in Biological Science University of Florence.

2005: PhD in Experimental and Clinical Oncology University of Florence.

2009: Master: Hemostasis and Thrombosis, from Molecular Biology to Pharmacology University of Florence.

ACCADEMIC POSITION

2021-Today Assistant Professor (grade A) at the Department of Health Science Section of Clinical Pharmacology and Oncology University of Florence

2018-2021 Post-Doctoral fellowship at the Department of Health Science Section of Clinical Pharmacology and Oncology University of Florence.

2016-2018 Post-Doctoral fellowship at the University-Hospital.

2015-2016: Post-Doctoral fellowship at the Department of Experimental and Clinical Medicine University of Florence.

2012-2015: Principal Investigator (PI) of the project founded by Regione Toscana at the Department of Health Science Section of Clinical Pharmacology and Oncology University of Florence

2010-2012: Post-Doctoral fellowship at the Department of Clinical and Preclinical Pharmacology University of Florence.

2008-2009: Post-Doctoral fellowship at the Department of Experimental Pathology and Oncology University of Florence.

2002-2003: Research fellowship from Fulbright at the Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, Piscataway, NJ USA.

2000-2003: Research Fellow AIRC (FIRC) at the Department of Experimental Pathology and Oncology University of Florence.

AWARDS

2002-2003: Research fellowship from Fulbrigth Foundation at the Department of Molecular Genetics, Microbiology and Immunology, UMDNJ, Robert Wood Johnson Medical School, Piscataway, NJ, 08854 USA, laboratory of Prof. Gary Brewer.

FINANCIAL GRANT

2012-2015: Principal Investigator (PI) of the project founded by Regione Toscana Entitled “Poly(ADPribosyl)ation as a member of the regulators of mitochondrial function, implication in mitochondrial disorders”. At the Department of Health Science Section of Clinical Pharmacology and Oncology University of Florence.

SCIENTIFIC SOCIETY MEMBER

Società Italiana di Farmacologia (SIF)

Sigma-Xi The Scientific Research Honor Society

EDITORIAL BOARD

All-Life, Pharmacology Section

Frontiers, Pharmacology of Anti-Cancer Drugs

REVIEWER

Journal of Chemotherapy, Cancers, Cells, International Journal of Molecular Sciences and Pharmaceutical, Frontiers in Pharmacology.

SCIENTIFIC RECORDS

Andrea Lapucci is the author of 54 peer-reviewed articles, 3 book chapters, 16 conference proceedings and 2 patents.

Total Citations 1619; H-Index 23 (Scopus Basic Search)