Personale

Recapiti

Italiano

Curriculum

Pubblicazioni

Insegnamenti

English

Curriculum

Chiara TRAINI

Ruolo attuale:: Professore Associato
SSD:: BIOS-13/A - Istologia ed embriologia umana
Afferenza organizzativa:: Dipartimento di Medicina Sperimentale e Clinica

Recapiti

chiara.traini(AT)unifi.it

Chiara TRAINI

Curriculum

Percorso di Studi

2010 - Dottorato di Ricerca in Farmacologia e Tossicologia; Scuola di Dottorato in Farmacologia, Tossicologia e Chemioterapia, Università degli Studi di Firenze, ciclo XXII (01/01/2007-31/12/2009). Titolo della Tesi: Ruolo dei recettori P1 e P2 purinergici nella neurotrasmissione e negli eventi molecolari che si attivano precocemente durante ischemia nell’ippocampo di ratto in vitro. Supervisore: Prof.ssa Anna Maria Pugliese.

2006 - Laurea in Scienze Biologiche, Università degli Studi di Firenze (110/110 e lode). Titolo della tesi: Effetti degli antagonisti A3 adenosinergici sulla neurotrasmissione ippocampale di ratto in un modello di ischemia in vitro.

Percorso Scientifico e Professionale

2021 - ad oggi Ricercatore a tempo determinato di tipologia b), di cui all’art. 24 della legge 240/2010. Struttura di afferenza: Dipartimento di Medicina Sperimentale e Clinica (DMSC), Unità di Ricerca di Istologia ed Embriologia, SSD BIO/17, Università degli Studi di Firenze.

2019 - 2021 Docente a contratto. Struttura di afferenza: Dipartimento di Medicina Sperimentale e Clinica (DMSC), Università degli Studi di Firenze. Corso di Laurea in INFERMIERISTICA, Scuola di Scienze della Salute Umana. Modulo: ISTOLOGIA, BIO/17 per l’insegnamento di Scienze morfologiche, a.a. 2019/2020

2021 Assegnista di ricerca (Art.22, legge 240/2010). Struttura di afferenza: Dipartimento di Medicina Sperimentale e Clinica (DMSC), Unità di Ricerca di Istologia ed Embriologia, SSD BIO/17, Università degli Studi di Firenze. Titolo del progetto: Studio morfologico biochimico e funzionale degli effetti protettivi di probiotici e dell'ormone GLP-2 sui danni chemioterapici della parete intestinale e del microbiota di topo.

2020 Visiting Researcher presso il gruppo diretto dal Prof Peer Wulff, Physiologisches Institut, Universität zu Kiel, Germania

2017 - 2020 Assegnista di ricerca (Art.22, legge 240/2010). Struttura di afferenza: Dipartimento di Medicina Sperimentale e Clinica (DMSC), Unità di Ricerca di Istologia ed Embriologia, SSD BIO/17, Università degli Studi di Firenze. Titolo del progetto: Il ruolo dell’asse microbiota-intestino-cervello nello stress psicosociale. Studio multidisciplinare in un modello animale di stress cronico.

2015 -2017 Borsista di ricerca. Struttura di afferenza: Dipartimento di Medicina Sperimentale e Clinica (DMSC), Unità di Ricerca di Istologia ed Embriologia, SSD BIO/17, Università degli Studi di Firenze. Titolo del progetto: Functional and morphological effects of otilonium bromide in an animal model of irritable bowel syndrome.

2011 - 2015 Assegnista di ricerca (Art.51, comma 6, legge 27 Dicembre 1997, n.449). Struttura di afferenza: Dipartimento di Medicina Sperimentale e Clinica (DMSC), Unità di Ricerca di Istologia ed Embriologia, SSD BIO/17, Università degli Studi di Firenze. Titolo del progetto: Effect of otilonium bromide on the plasma-membrane specializations of the gastrointestinal smooth muscle cells and interstitial cells of Cajal.

2010 - 2011 Assegnista di ricerca (Art.51, comma 6, legge 27 Dicembre 1997, n.449) Struttura di afferenza: Dipartimento di Neuroscienze, Psicologia, Area del farmaco e Salute del bambino (NEUROFARBA), Università degli Studi di Firenze. Titolo del progetto: Effetto di farmaci neuroprotettivi in un modello murino di malattia di Alzheimer.

2010 Borsista di ricerca. Struttura di afferenza: Dipartimento di Neuroscienze, Psicologia, Area del farmaco e Salute del bambino (NEUROFARBA), Università degli Studi di Firenze. Titolo del progetto: Studio delle modificazioni elettrofisiologiche e molecolari che si attivano precocemente nella neurodegenerazione ischemica.

Chiara TRAINI

Pubblicazioni

Legenda

Contributo su rivista |

Articolo su libro |

Libro |

Contributo in atti di convegno (proceeding) |

Brevetto |

Curatela | Altro

Altro |

Tesi di Dottorato

Eglantina Idrizaj, Cristina Biagioni, Chiara Traini, Maria Giuliana Vannucchi, Maria Caterina Baccari (2024). Glucagon-like Peptide-2 Depresses Ileal Contractility in Preparations from Mice through Opposite Modulatory Effects on Nitrergic and Cholinergic Neurotransmission. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 25, pp. 1-13, ISSN:1422-0067 DOI

Lana, Daniele; Traini, Chiara; Bulli, Irene; Sarti, Giorgia; Magni, Giada; Attorre, Selene; Giovannini, Maria Grazia; Vannucchi, Maria Giuliana (2024). Chronic administration of prebiotics and probiotics ameliorates pathophysiological hallmarks of Alzheimer’s disease in a APP/PS1 transgenic mouse model. FRONTIERS IN PHARMACOLOGY, vol. 15, pp. 1-21, ISSN:1663-9812 DOI

Cristina Biagioni, Chiara Traini, Maria Simonetta Faussone-Pellegrini, | Eglantina Idrizaj, Maria Caterina Baccari, Maria Giuliana Vannucchi (2024). Prebiotics counteract the morphological and functional changes secondary to chronic cisplatin exposition in the proximal colon of mice.. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. ..., pp. 1-12, ISSN:1582-4934 DOI

Traini, Chiara; Bulli, Irene; Sarti, Giorgia; Morecchiato, Fabio; Coppi, Marco; Rossolini, Gian Maria; Di Pilato, Vincenzo; Vannucchi, Maria Giuliana (2024). Amelioration of Serum Aβ Levels and Cognitive Impairment in APPPS1 Transgenic Mice Following Symbiotic Administration. NUTRIENTS, vol. 16, pp. 0-0, ISSN:2072-6643 DOI

Chiara Traini, Eglantina Idrizaj, Cristina Biagioni, Maria Caterina Baccari, Maria Giuliana Vannucchi (2023). Otilonium Bromide Prevents Cholinergic Changes in the Distal Colon Induced by Chronic Water Avoidance Stress, a Rat Model of Irritable Bowel Syndrome. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 24, pp. 1-13, ISSN:1422-0067 DOI

Traini C.; Nistri S.; Calosi L.; Vannucchi M.G. (2022). Chronic Exposure to Cigarette Smoke Affects the Ileum and Colon of Guinea Pigs Differently. Relaxin (RLX-2, Serelaxin) Prevents Most Local Damage. FRONTIERS IN PHARMACOLOGY, vol. 12, pp. 0-0, ISSN:1663-9812 DOI

Giovannini, MG; Lana, D; Traini, C; Vannucchi, MG (2021). The Microbiota-Gut-Brain Axis and Alzheimer Disease. From Dysbiosis to Neurodegeneration: Focus on the Central Nervous System Glial Cells. JOURNAL OF CLINICAL MEDICINE, vol. 10, pp. 2358-2370, ISSN:2077-0383 DOI

Traini, C; Idrizaj, E; Garella, R; Faussone-Pellegrini, MS; Baccari, MC; Vannucchi, MG (2021). Otilonium Bromide treatment prevents nitrergic functional and morphological changes caused by chronic stress in the distal colon of a rat IBS model. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, pp. 1-13, ISSN:1582-1838 DOI

Eglantina Idrizaj, Chiara Traini, Maria Giuliana Vannucchi, Maria Caterina Baccari (2021). Nitric Oxide: From Gastric Motility to Gastric Dysmotility. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, pp. 1-14, ISSN:1422-0067 DOI

Sara Traserra, Sonia Villarte, Chiara Traini, Sara Palacin, Patri Vergara, Maria Giuliana Vannucchi, Marcel Jimenez (2020). The asymmetric innervation of the circular and longitudinal muscle of the mouse colon differently modulates myogenic slow phasic contractions.. NEUROGASTROENTEROLOGY & MOTILITY, vol. ..., pp. 0-0, ISSN:1365-2982

Chiara Traini; Maria-Simonetta Faussone-Pellegrini; Maria Giuliana Vannucchi; Gianluca Cipriani (2020). Muscularis macrophages establish cell-to-cell contacts with telocytes/PDGFR-positive cells and smooth muscle cells in the human and mouse gastrointestinal tract. JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY, pp. 1-13, ISSN:2093-0879

Chiara Traini, Eglantina Idrizaj, Rachele Garella, Roberta Squecco, Maria Giuliana Vannucchi, Maria Caterina Baccari (2020). Glucagon-like peptide-2 interferes with the neurally-induced relaxant responses in the mouse gastric strips through VIP release. NEUROPEPTIDES, vol. 19, pp. 0-0, ISSN:0143-4179 DOI

Amedei A.; Asadzadeh F.; Papi F.; Vannucchi M.G.; Ferrucci V.; Bermejo I.A.; Fragai M.; De Almeida C.V.; Cerofolini L.; Giuntini S.; Bombaci M.; Pesce E.; Niccolai E.; Natali F.; Guarini E.; Gabel F.; Traini C.; Catarinicchia S.; Ricci F.; Orzalesi L.; Berti F.; Corzana F.; Zollo M.; Grifantini R.; Nativi C. (2020). A Structurally Simple Vaccine Candidate Reduces Progression and Dissemination of Triple-Negative Breast Cancer. ISCIENCE, vol. 23, pp. 0-53, ISSN:2589-0042 DOI

Traini C, Garella R, Idrizaj E, Squecco R, Vannucchi MG, Baccari MC (2019). The potential role of chronic otilonium bromide administration in preventing colonic dysmotility induced by repeated water avoidance stress in rats. ACTA PHYSIOLOGICA, vol. 227, pp. 120-120, ISSN:1748-1708

Traini C; Del Popolo G; Faussone-Pellegrini MS; Guasti D; Catarinicchia S; Vannucchi MG (2019). Nerve sprouting and neurogenic inflammation characterize the neurogenic detrusor overactive bladder of patients no longer responsive to drug therapies.. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. 23, pp. 4076-4087, ISSN:1582-1838

Traini C; Vannucchi MG (2019). The Botulinum Treatment of Neurogenic Detrusor Overactivity: The Double-Face of the Neurotoxin.. TOXINS, vol. 11, pp. 1-15, ISSN:2072-6651

Traini, C; Del Popolo, G; Vannucchi, MG (2019). Nerve, muscle and connective changes in the bladder of neurogenic detrusor overactive affected patients no longer responsive to botulinum toxin.. NEUROUROLOGY AND URODYNAMICS, vol. 38, pp. 39-41, ISSN:0733-2467

Traini, C; Del Popolo, G; Vannucchi, MG (2018). TELOCYTES AND INNERVATION OF THE HUMAN BLADDER LAMINA PROPRIA AND THEIR ROLE IN THE AFFERENT INPUTS IN THE NEUROGENIC DETRUSOR OVERACTIVITY. NEUROUROLOGY AND URODYNAMICS, vol. 37, pp. S48-S49, ISSN:0733-2467

Vannucchi MG; Traini C; (2018). The telocytes/myofibroblasts 3-D network forms a stretch receptor in the human bladder mucosa. Is this structure involved in the detrusor overactive diseases?. ANNALS OF ANATOMY, vol. 218, pp. 118-123, ISSN:0940-9602

Evangelista S; Traini C; Vannucchi MG; (2018). Otilonium bromide: a drug with a complex mechanism of action.. CURRENT PHARMACEUTICAL DESIGN, vol. 24, pp. 1772-1779, ISSN:1381-6128

Chiara Traini, Maria-Simonetta Fausssone-Pellegrini, Daniele Guasti, Giulio Del Popolo, Jacopo Frizzi, Sergio Serni, Maria-Giuliana Vannucchi (2018). Adaptive changes of telocytes in the urinary bladder of patients affected by neurogenic detrusor overactivity.. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. 22, pp. 0-0, ISSN:1582-1838 DOI Accesso ONLINE all'editore

Chiara Traini, Stefano Evangelista, Vincent Girod, Maria Simonetta Faussone-Pellegrini, Maria Giuliana Vannucchi (2017). Repeated otilonium bromide administration prevents neurotransmitter changes in colon of rats underwent to wrap restraint stress.. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. 2, pp. 735-745, ISSN:1582-4934 DOI

Garella, Rachele; Idrizaj, Eglantina; Traini, Chiara; Squecco, Roberta; Maria Giuliana Vannucchi, ; Maria Caterina Baccari, (2017). Glucagon-like peptide-2 modulates the nitrergic neurotransmission in strips from the mouse gastric fundus.. WORLD JOURNAL OF GASTROENTEROLOGY, vol. 23, pp. 7211-7220, ISSN:2219-2840 DOI

C. TRAINI, S. EVANGELISTA, V. GIROD, M.S. FAUSSONE-PELLEGRINI, M.G. VANNUCCHI (2016). Changes of excitatory and inhibitory neurotransmitters in the colon of rats underwent to the wrap partial restraint stress.. NEUROGASTROENTEROLOGY & MOTILITY, vol. 28, pp. 1172-1185, ISSN:1365-2982 DOI Accesso ONLINE all'editore

Vannucchi, MG; Traini, C (2016). Interstitial cells of Cajal and telocytes in the gut: twins, related or simply neighbor cells?. BIOMOLECULAR CONCEPTS, vol. 7, pp. 93-102, ISSN:1868-503X DOI

Traini C; Faussone-Pellegrini MS; Evangelista S; Mazzaferro K; Cipriani G; Santicioli P; Vannucchi MG (2014). Inner and Outer Portions of Colonic Circular Muscle: Ultrastructural and Immunohistochemical Changes in Rat Chronically Treated with Otilonium Bromide. PLOS ONE, vol. 9, pp. 1-11, ISSN:1932-6203 DOI

Vannucchi MG; Traini C; Guasti D; Del Popolo G; Faussone-Pellegrini MS (2014). Telocytes subtypes in human urinary bladder.. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, pp. 2000-2008, ISSN:1582-4934

Traini C; Cipriani G; Evangelista S; Santicioli P; Faussone-Pellegrini MS; Vannucchi MG (2013). Chronic treatment with otilonium bromide induces changes in L-type Ca²⁺ channel, tachykinins, and nitric oxide synthase expression in rat colon muscle coat.. NEUROGASTROENTEROLOGY & MOTILITY, vol. 25, pp. 728-739, ISSN:1365-2982

MG Vannucchi; C Traini; M. Manetti; L Ibba-Manneschi; MS Faussone-Pellegrini (2013). Telocytes express PDGFR-alpha in the human gastrointestinal tract. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. 17, pp. 1099-1108, ISSN:1582-1838 DOI

Francesca Tatini; Anna Maria Pugliese; Chiara Traini; Sandra Niccoli; Giovanna Maraula; Teresa Ed Dami; Benedetta Mannini; Tania Scartabelli; Felicita Pedata; Fiorella Casamenti; Fabrizio Chiti (2013). Amyloid-β oligomer synaptotoxicity is mimicked by oligomers of the model protein HypF-N. NEUROBIOLOGY OF AGING, vol. 34, pp. 2100-2109, ISSN:0197-4580 DOI

M. Muzzi;F. Blasi;A. Masi;E. Coppi;C. Traini;R. Felici;M. Pittelli;L. Cavone;A. M. Pugliese;F. Moroni;A. Chiarugi (2013). Neurological basis of AMP-dependent thermoregulation and its relevance to central and peripheral hyperthermia.. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, vol. 33, pp. 183-190, ISSN:0271-678X DOI Accesso ONLINE all'editore

C. Grossi; S. Rigacci; S. Ambrosini; T. Ed Dami; I. Luccarini; C. Traini; P. Failli; A. Berti; F. Casamenti; M. Stefani (2013). The polyphenol oleuropein aglycone protects TgCRND8 mice against Aß plaque pathology. PLOS ONE, vol. 8, pp. 1-13, ISSN:1932-6203

Maraula G.; Traini C.; Mello T.; Coppi E.; Galli A.; Pedata F.; Pugliese A.M. (2013). The selective antagonism of A2A adenosine receptors prevents synaptic failure induced by oxygen and glucose deprivation in rat dentate gyrus. In: 6th European Congress of Pharmacology, Granada, Spain, JUL 17-20, 2012, Zarzuelo, A; Jimenez, R, pp. 255-258.

Mirko Muzzi; Francesco Blasi; Alessio Masi; Elisabetta Coppi; Chiara Traini; Roberta Felici; Maria Pittelli; Leonardo Cavone; Anna Maria Pugliese; Flavio Moroni; Alberto Chiarugi (2013). Neurological basis of AMP-dependent thermoregulation and its relevance to central and peripheral hyperthermia. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, pp. 183-190, ISSN:0271-678X

Maraula G; Traini C; Mello T; Pedata F; Pugliese AM (2012). Effects of oxygen and glucose deprivation on synaptic transmission and neural progenitor cells maturation in rat dentate gyrus: role of A 2A adenosine receptors. In: Sixth EPHAR Congress, Granada 2012, E-Journal of British Pharmacological Society, pp. P476-P476.

Maraula G;Traini C;Mello T;Coppi E;Galli A;Pedata F;Pugliese AM (2012). Effects of oxygen and glucose deprivation on synaptic transmission in rat dentate gyrus: Role of A(2A) adenosine receptors.. NEUROPHARMACOLOGY, vol. 67, pp. 511-520, ISSN:0028-3908 DOI

Chiara Traini; Gianluca Cipriani; Stefano Evangelista; Paolo Santicioli; Maria Simonetta Faussone-Pellegrini; Maria Giuliana Vannucchi (2012). Long-term effects of otilonium bromide on tachykinin receptors, substance P and NOS expression in the rat colon muscle coat. NEUROGASTROENTEROLOGY & MOTILITY, vol. 24 suppl 2, pp. 61-62, ISSN:1365-2982

Traini C; Cipriani G; Evangelista S; Santiccioli P; Faussone-Pellegrini MS; Vannucchi MG (2012). Chronic treatment with otilonium bromide affects the tachykinergic and nitrergic systems in the rat colon.. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 117, Suppl. 2, pp. 194-194, ISSN:1122-6714

Luccarini I; Grossi C; Traini C; Fiorentini A; Ed Dami T; Casamenti F (2012). Aβ plaque-associated glial reaction as a determinant of apoptotic neuronal death and cortical gliogenesis: a study in APP mutant mice. NEUROSCIENCE LETTERS, vol. 506, pp. 94-99, ISSN:0304-3940

MC Baccari; C Traini; R Garella; G Cipriani; MG Vannucchi (2012). Relaxin exerts two opposite effects on mechanical activity and nitric oxide synthase expression in the mouse colon.. AMERICAN JOURNAL OF PHYSIOLOGY: ENDOCRINOLOGY AND METABOLISM, vol. 303, pp. 1142-1150, ISSN:0193-1849 DOI

Traini C; Cipriani G; Garella R; Baccari MC; Vannucchi MG (2011). Relaxin increase contractile activity and neuronal Nitric Oxide synthase (nNOS) expression in the muscle coat of mouse colon.. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 116, Suppl. 1, pp. 188-188, ISSN:1122-6714

R.Garella; C. Traini; G. Cipriani; M.G. Vannucchi; M.C. Baccari (2011). Relaxin exerts a dual effect on the mechanical activity of the mouse colonic strips through the regulation of nNOS expression. In: SIF, pp. 12-12.

Ed Dami T; Fiorentini A; Luccarini I; Traini C; Grossi C; Casamenti F. (2011). Adult hippocampal neurogenesis and cortical gliogenesis in APP mutant mice. In: Congresso IBRO, Firenze, pp. 381-381.

C. Traini; F. Pedata; S. Cipriani; T. Mello; A. Galli; M.G. Giovannini; F. Cerbai; R. Volpini; G. Cristalli; A.M. Pugliese (2011). P2 receptor antagonists prevent synaptic failure and extracellular signal-regulated kinase 1/2 activation induced by oxygen and glucose deprivation in rat CA1 hippocampus in vitro.. EUROPEAN JOURNAL OF NEUROSCIENCE, vol. 33, pp. 2203-2215, ISSN:0953-816X DOI

Pugliese AM ; Traini C; Marangoni M ; Cipriani S; Pedata F (2010). Role of purinergic P2 receptors on neuronal survival and ERK1/2 activation after oxygen-glucose deprivation in the CA1 region of the rat hippocampus. PURINERGIC SIGNALLING, vol. 6, suppl 1, pp. 101-101, ISSN:1573-9538 DOI

Pedata F.; Melani A.; Cipriani S.; Pugliese A.M.; Traini C.; Corti F.; Giovannini MG. (2010). Adenosine A2A antagonists are protective in in vivo and in vitro models of brain ischemia.. PURINERGIC SIGNALLING, vol. 6 (Suppl. 1), pp. S20-S21, ISSN:1573-9538, SPRINGER: DOI

Pugliese AM; Traini C; Cipriani S; Mello T; Galli A; Pedata F (2010). Antagonism of purinergic P2 receptors enhances neuronal survival and decreases ERK1/2 activation after oxygen-glucose deprivation in rat CA1 hippocampal slices. PURINERGIC SIGNALLING, vol. 6(1), pp. 55-56, ISSN:1573-9538 DOI

V. Colotta; O. Lenzi; D. Catarzi; F. Varano; G. Filacchioni; C. Martini; L. Trincavelli; O. Ciampi; A. M. Pugliese; C. Traini; F. Pedata; E. Morizzo; S. Moro (2009). Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a New Scaffold To Develop Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation, and Ligand-Receptor Modeling Studies.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, pp. 2407-2419, ISSN:0022-2623 DOI

A.M. Pugliese; C. Traini; S. Cipriani; M. Gianfriddo; T. Mello ; M.G. Giovannini; A. Galli; F. Pedata (2009). THE ADENOSINE A2A RECEPTOR ANTAGONIST ZM241385 ENHANCES NEURONAL SURVIVAL DURING OXYGEN-GLUCOSE DEPRIVATION IN RAT CA1 HIPPOCAMPUS. BRITISH JOURNAL OF PHARMACOLOGY, vol. 157, pp. 818-830, ISSN:0007-1188 DOI Accesso ONLINE all'editore

PUGLIESE A.M.; TRAINI C.; CIPRIANI S.; MELLO T.; CORRADETTI R.; GALLI A.; PEDATA; F (2009). Role of purinergic P2 receptors on neuronal survival and MAPK activation during oxygen-glucose deprivation in the rat CA1 hippocampus. In: 2009 Neuroscience Meeting Planner. Chicago, IL: Society for Neuroscience, 2009. Online, pp. Program No. 52.13/J1-Program No. 52.13/J1.

V.COLOTTA; D.CATARZI; F.VARANO; O.LENZI; G.FILACCHIONI; C.MARTINI; L.TRINCAVELLI; O.CIAMPI; C.TRAINI; A.PUGLIESE; F.PEDATA; E.MORIZZO; S.MORO. (2008). Synthesis, ligand-receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, pp. 6086-6102, ISSN:0968-0896 DOI

Pugliese A.M.; Traini C.; Gianfriddo M.; Mello T.; Galli A.; Pedata F. (2008). Blocking adenosine A2A receptors during oxigen-glucose deprivation delays anoxic depolarization and ameliorates neuronal survival in the rat CA1 hippocampus. PURINERGIC SIGNALLING, vol. 4(suppl.1), pp. S43-S43, ISSN:1573-9538 DOI

F. PEDATA; A. MELANI; A.M. PUGLIESE ; E. COPPI; S. CIPRIANI; C. TRAINI (2007). The role of ATP and adenosine in the brain under normoxic and ischemic conditions.. PURINERGIC SIGNALLING, vol. 3, pp. 299-310, ISSN:1573-9538 DOI

Chiara TRAINI

Curriculum

Education

2010 - PhD in Pharmacology and Toxicology; School in Pharmacology, Toxicology and Chemotherapy, University of Florence, XXII cycle (01/01/2007-31/12/2009). Thesis title: Role of purinergic P1 and P2 receptors in neurotransmission and in molecular events early activated during ischemia in rat hippocampus in vitro. Supervisor: Prof. Anna Maria Pugliese.

2006 - Degree in Biological Sciences, University of Florence (110/110 cum laude). Thesis title: Effects of adenosinergic A3 antagonists on rat hippocampal neurotransmission in an in vitro ischemia model.

Work experience

2021 - to date. Researcher type b (art. 24 of law 240/2010). Affiliation: Department of Experimental and Clinical Medicine, Histology and Embryology Research Unit, SSD BIO/17, University of Florence.

2019 - 2021 Teacher. Affiliation: Department of Experimental and Clinical Medicine (DMSC), University of Florence. Degree Course in NURSING, School of Human Health Sciences. Module: HISTOLOGY, BIO/17 (Morphological Sciences), a.y. 2019/2020.

2021 Post-doctoral fellowship (Art.22, law 240/2010). Affiliation: Department of Experimental and Clinical Medicine (DMSC), Histology and Embryology Research Unit, SSD BIO/17, University of Florence. Project title: Protective effects of probiotics and the GLP-2 hormone treatment on chemotherapeutic damage in the mouse intestinal wall. Biochemical, functional and morphological study.

2020 Visiting Researcher in the group directed by Prof Peer Wulff, at Physiologisches Institut, Universität zu Kiel, Germany.

2017 - 2020 Post-doctoral fellowship (Art.22, law 240/2010). Affiliation: Department of Experimental and Clinical Medicine (DMSC), Histology and Embryology Research Unit, SSD BIO/17, University of Florence. Project title: The role of the microbiota-gut-brain axis in psychosocial stress. Multidisciplinary study in an animal model of chronic stress.

2015 -2017 Research fellowship. Affiliation: Department of Experimental and Clinical Medicine (DMSC), Histology and Embryology Research Unit, SSD BIO/17, University of Florence. Project title: Functional and morphological effects of otilonium bromide in an animal model of irritable bowel syndrome.

2011 - 2015 Post-doctoral fellowship (Art.51, paragraph 6, law 27 December 1997, n.449). Affiliation: Department of Experimental and Clinical Medicine (DMSC), Histology and Embryology Research Unit, SSD BIO/17, University of Florence. Project title: Effect of otilonium bromide on the plasma-membrane specializations of the gastrointestinal smooth muscle cells and interstitial cells of Cajal.

2010 - 2011 Post-doctoral fellowship (Art.51, paragraph 6, law 27 December 1997, n.449) Affiliation: Department of Neuroscience, Psychology, Drug Area and Child Health (NEUROFARBA), University of Florence. Project title: Effect of neuroprotective drugs in a mouse model of Alzheimer's disease.

2010 Research fellowship. Affiliation: Department of Neuroscience, Psychology, Drug Area and Child Health (NEUROFARBA), University of Florence. Project title: Study of the electrophysiological and molecular changes early activated in ischemic neurodegeneration.