Ippolito, Luigi; Duatti, Assia; Iozzo, Marta; Comito, Giuseppina; Pardella, Elisa; Lorito, Nicla; Bacci, Marina; Pranzini, Erica; Santi, Alice; Sandrini, Giada; Catapano, Carlo V; Serni, Sergio; Spatafora, Pietro; Morandi, Andrea; Giannoni, Elisa; Chiarugi, Paola (2024). Lactate supports cell-autonomous ECM production to sustain metastatic behavior in prostate cancer. EMBO REPORTS, pp. 0-0, ISSN:1469-3178 DOI  

  Bacci, Marina; Lorito, Nicla; Smiriglia, Alfredo; Subbiani, Angela; Bonechi, Francesca; Comito, Giuseppina; Morriset, Ludivine; El Botty, Rania; Benelli, Matteo; López-Velazco, Joanna I; Caffarel, Maria M; Urruticoechea, Ander; Sflomos, George; Malorni, Luca; Corsini, Michela; Ippolito, Luigi; Giannoni, Elisa; Meattini, Icro; Matafora, Vittoria; Havas, Kristina; Bachi, Angela; Chiarugi, Paola; Marangoni, Elisabetta; Morandi, Andrea (2024). Acetyl-CoA carboxylase 1 controls a lipid droplet-peroxisome axis and is a vulnerability of endocrine-resistant ER+ breast cancer. SCIENCE TRANSLATIONAL MEDICINE, vol. 16, pp. 0-0, ISSN:1946-6242 DOI  

  Lorito, Nicla; Subbiani, Angela; Smiriglia, Alfredo; Bacci, Marina; Bonechi, Francesca; Tronci, Laura; Romano, Elisabetta; Corrado, Alessia; Longo, Dario Livio; Iozzo, Marta; Ippolito, Luigi; Comito, Giuseppina; Giannoni, Elisa; Meattini, Icro; Avgustinova, Alexandra; Chiarugi, Paola; Bachi, Angela; Morandi, Andrea (2024). FADS1/2 control lipid metabolism and ferroptosis susceptibility in triple-negative breast cancer. EMBO MOLECULAR MEDICINE, pp. 0-0, ISSN:1757-4684 DOI  

  Ippolito, Luigi; Comito, Giuseppina; Parri, Matteo; Iozzo, Marta; Duatti, Assia; Virgilio, Francesca; Lorito, Nicla; Bacci, Marina; Pardella, Elisa; Sandrini, Giada; Bianchini, Francesca; Damiano, Roberta; Ferrone, Lavinia; la Marca, Giancarlo; Serni, Sergio; Spatafora, Pietro; Catapano, Carlo V; Morandi, Andrea; Giannoni, Elisa; Chiarugi, Paola (2022). Lactate rewires lipid metabolism and sustains a metabolic-epigenetic axis in prostate cancer. CANCER RESEARCH, pp. canres.0914.2021-canres.0914.2021, ISSN:0008-5472 DOI  

  Iozzo M.; Sgrignani G.; Comito G.; Chiarugi P.; Giannoni E. (2021). Endocannabinoid system and tumour microenvironment: New intertwined connections for anticancer approaches. CELLS, vol. 10, pp. 3396-3430, ISSN:2073-4409 DOI  

  Comito G.; Ippolito L.; Chiarugi P.; Cirri P. (2020). Nutritional Exchanges Within Tumor Microenvironment: Impact for Cancer Aggressiveness. FRONTIERS IN ONCOLOGY, vol. 10, pp. 396-405, ISSN:2234-943X DOI  

  Antonio Pezone, Maria Letizia Taddei, Alfonso Tramontano, Jacopo Dolcini, Francesca Ludovica Boffo, Mariarosaria De Rosa, Matteo Parri, Stefano Stinziani, Giuseppina Comito, Antonio Porcellini, Giovanni Raugei, Daniel Gackowski, Ewelina Zarakowska, Ryszard Olinski, Armando Gabrielli, Paola Chiarugi, Enrico Vittorio Avvedimento (2020). Targeted DNA oxidation by LSD1-SMAD2/3 primes TGF-β1/ EMT genes for activation or repression. NUCLEIC ACIDS RESEARCH, vol. 48, pp. 8943-8958, ISSN:0305-1048 DOI   Accesso ONLINE all'editore

  Lorito, Nicla; Bacci, Marina; Smiriglia, Alfredo; Mannelli, Michele; Parri, Matteo; Comito, Giuseppina; Ippolito, Luigi; Giannoni, Elisa; Bonechi, Martina; Benelli, Matteo; Migliaccio, Ilenia; Malorni, Luca; Chiarugi, Paola; Morandi, Andrea (2020). Glucose Metabolic Reprogramming of ER Breast Cancer in Acquired Resistance to the CDK4/6 Inhibitor Palbociclib. CELLS, vol. 9, pp. 0-0, ISSN:2073-4409 DOI  

  Bacci M.; Lorito N.; Ippolito L.; Ramazzotti M.; Luti S.; Romagnoli S.; Parri M.; Bianchini F.; Cappellesso F.; Virga F.; Gao Q.; Simoes B.M.; Marangoni E.; Martin L.-A.; Comito G.; Ferracin M.; Giannoni E.; Mazzone M.; Chiarugi P.; Morandi A. (2019). Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer. CELL REPORTS, vol. 28, pp. 104-118.e8, ISSN:2211-1247 DOI   Accesso ONLINE all'editore

  Comito, G.; Iscaro, A.; Bacci, M.; Morandi, A.; Ippolito, L.; Parri, M.; Montagnani, I.; Raspollini, M.R.; Serni, S.; Simeoni, L.; Giannoni, E.*; Chiarugi, P. (2019). Lactate modulates CD4 + T-cell polarization and induces an immunosuppressive environment, which sustains prostate carcinoma progression via TLR8/miR21 axis. ONCOGENE, vol. 38 (19), pp. 3681-3695, ISSN:0950-9232, Nature Publishing Group: DOI   Accesso ONLINE all'editore

  Pietrovito L, Comito G, Parri M, Giannoni E, Chiarugi P, Taddei ML. (2019). Zoledronic Acid Inhibits the RhoA-mediated Amoeboid Motility of Prostate Cancer Cells.. CURRENT CANCER DRUG TARGETS, vol. 19, pp. 807-816, ISSN:1873-5576 DOI  

  Ippolito, Luigi; Morandi, Andrea; Taddei, Maria Letizia; Parri, Matteo; Comito, Giuseppina; Iscaro, Alessandra; Raspollini, Maria Rosaria; Magherini, Francesca; Rapizzi, Elena; Masquelier, Julien; Muccioli, Giulio G; Sonveaux, Pierre; Chiarugi, Paola; Giannoni, Elisa (2019). Cancer-associated fibroblasts promote prostate cancer malignancy via metabolic rewiring and mitochondrial transfer. ONCOGENE, vol. 38, pp. 5339-5355, ISSN:0950-9232 DOI   Accesso ONLINE all'editore

  Taddei, Maria Letizia*; Cavallini, Lorenzo; Ramazzotti, Matteo; Comito, Giuseppina; Pietrovito, Laura; Morandi, Andrea; Giannoni, Elisa; Raugei, Giovanni; Chiarugi, Paola (2018). Stromal-induced downregulation of miR-1247 promotes prostate cancer malignancy. JOURNAL OF CELLULAR PHYSIOLOGY, vol. 6, pp. 8274-8285, ISSN:0021-9541 DOI   Accesso ONLINE all'editore

  Arosio, Paolo; Comito, Giuseppina; Orsini, Francesco; Lascialfari, Alessandro; Chiarugi, Paola; Ménard-Moyon, Cécilia*; Nativi, Cristina; Richichi, Barbara (2018). Conjugation of a GM3 lactone mimetic on carbon nanotubes enhances the related inhibition of melanoma-associated metastatic events. ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 16, pp. 6086-6095, ISSN:1477-0520 DOI   Accesso ONLINE all'editore

  Fragai, Marco; Comito, Giuseppina; Di Cesare Mannelli, Lorenzo; Gualdani, Roberta; Calderone, Vito; Louka, Alexandra; Richichi, Barbara; Francesconi, Oscar; Angeli, Andrea; Nocentini, Alessio; Gratteri, Paola; Chiarugi, Paola; Ghelardini, Carla; Tadini-Buoninsegni, Francesco; Supuran, Claudiu T; Nativi, Cristina (2017). Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX). JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, pp. 9003-9011, ISSN:1520-4804 DOI  

  Richichi, Barbara; Comito, Giuseppina; Renaudet, Olivier; Fiore, Michele; Marra, A.; Stecca, B.; Pasquato, L.; Chiarugi, P.; Nativi, C. (2016). Role of a Preorganized Scaffold Presenting Four Residues of a GM‑3 Lactone Mimetic on Melanoma Progression. ACS MEDICINAL CHEMISTRY LETTERS, vol. 7, pp. 28-33, ISSN:1948-5875 DOI   Accesso ONLINE all'editore

  Barcellos-de-Souza, P; Comito, G; Pons-Segura, C; Taddei, ML; Gori, V; Becherucci, V; Bambi, F; Margheri, F; Laurenzana, A; Del Rosso, M; Chiarugi, P; (2016). Mesenchymal Stem Cells are Recruited and Activated into Carcinoma-Associated Fibroblasts by Prostate Cancer Microenvironment-Derived TGF-β1. STEM CELLS, vol. 34, pp. 2536-2547, ISSN:1066-5099 DOI   Accesso ONLINE all'editore

  Comito, G; Segura, Cp; Taddei, Ml; Lanciotti, M; Serni, S; Morandi, A; Chiarugi, P; Giannoni, E (2016). Zoledronic acid impairs stromal reactivity by inhibiting M2-macrophages polarization and prostate cancer-associated fibroblasts.. ONCOTARGET, vol. ..8, pp. 118-132, ISSN:1949-2553 DOI   Accesso ONLINE all'editore

  Giannoni, E; Taddei, Ml; Morandi, A; Comito, G; Calvani, M; Bianchini, F; Richichi, B; Raugei, G; Wong, N; Tang, D; Chiarugi, P. (2015). Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs OXPHOS and prostate cancer metastatic spread. ONCOTARGET, vol. 6(27), pp. 24061-24074, ISSN:1949-2553 DOI   Accesso ONLINE all'editore

  Calvani M, Pelon F, Comito G, Taddei ML, Moretti S, Innocenti S, Nassini R, Gerlini S, Borgognoni, Bambi F, Giannoni E, Filippi L, Chiarugi P. (2015). Norepinephrine promotes tumor microenvironment reactivity through β3-adrenoreceptors during melanoma progression.. ONCOTARGET, vol. 6, pp. 4615-4632, ISSN:1949-2553 DOI   Accesso ONLINE all'editore

  Comito G; Giannoni E; Segura CP; Barcellos-de-Souza P; Raspollini MR; Baroni G; Lanciotti M; Serni S; Chiarugi P. (2014). Cancer-associated fibroblasts and M2-polarized macrophages synergize during prostate carcinoma progression.. ONCOGENE, vol. 33(19), pp. 2423-2431, ISSN:0950-9232 DOI  

  Renato Ribeiro-Viana;Elena Bonechi;Javier Rojo;Clara Ballerini;Giuseppina Comito;Barbara Richichi;Cristina Nativi (2014). Human dendritic cell activation induced by a permannosylated dendron containing an antigenic GM3-lactone mimetic. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, vol. 10, pp. 1317-1324, ISSN:1860-5397 DOI  

  Taddei ML; Cavallini L; Comito G; Giannoni E; Folini M; Marini A; Gandellini P; Morandi A; Pintus G; Raspollini MR; Zaffaroni N; Chiarugi P. (2014). Senescent stroma promotes prostate cancer progression: The role of miR-210. MOLECULAR ONCOLOGY, pp. 1729-1746, ISSN:1574-7891 DOI  

  Barbara Richichi;Giuseppina Comito;Linda Cerofolini;Gabriele Gabrielli;Alberto Marra;Lisa Moni;Alice Pace;Lucia Pasquato;Paola Chiarugi;Alessandro Dondoni;Lucio Toma;Cristina Nativi (2013). Multivalent presentation of ahydrolytically stable GM 3 lactone mimetic as modulator of melanoma cells motility and adhesion. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, pp. 2756-2763, ISSN:0968-0896 DOI  

  Taddei ML; Giannoni E; Comito G; Chiarugi P. (2013). Microenvironment and tumor cell plasticity: An easy way out.. CANCER LETTERS, pp. ?-?, ISSN:0304-3835

  Comito G; Giannoni E; Gennaro PD; Segura CP; Gerlini G; Chiarugi P. (2012). Stromal fibroblasts synergize with hypoxic oxidative stress to enhance melanoma aggressiveness.. CANCER LETTERS, vol. ----, pp. ----------, ISSN:0304-3835

  Calvani M; Comito G; Giannoni E; Chiarugi P. (2012). Time-dependent stabilization of hypoxia inducible factor-1α by different intracellular sources of reactive oxygen species.. PLOS ONE, vol. 7(10), pp. 1-11, ISSN:1932-6203

  G. Comito; M. Calvani; E. Giannoni; F. Bianchini; L. Calorini; E. Torre; C. Migliore; S. Giordano; P. Chiarugi (2011). HIF-1α stabilization by mitochondrial ROS promotes Met-dependent invasive growth and vasculogenic mimicry in melanoma cells.. FREE RADICAL BIOLOGY & MEDICINE, vol. 51(4), pp. 893-904, ISSN:0891-5849 DOI  

  T Fiaschi; D Cirelli; G Comito; S Gelmini; G Ramponi; M Serio; P Chiarugi (2009). Globular adiponectin induces differentiation and fusion of skeletal muscle cells. CELL RESEARCH, vol. 19(5), pp. 584-597, ISSN:1001-0602