Personale

Recapiti

Italiano

Biografia

Curriculum

Interessi

Pubblicazioni

Insegnamenti

English

Biography

Curriculum

Interest

Alessio NOCENTINI

Ruolo attuale:: Ricercatore Legge 240/10 a tempo determinato
SSD:: CHEM-07/A - Chimica farmaceutica
Afferenza organizzativa:: Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino (NEUROFARBA)

Recapiti

alessio.nocentini(AT)unifi.it

Alessio NOCENTINI

Curriculum

FORMAZIONE
2014–2017 Dottorato di Ricerca con lode in Area del Farmaco e Trattamenti Innovativi: Curriculum Scienze Farmaceutiche (Chimica Farmaceutica), Dipartimento NEUROFARBA, Università degli Studi di Firenze – Supervisore: Prof.ssa Paola Gratteri
2008–2014 Laurea Magistrale in Chimica e Tecnologia Farmaceutiche, 110/110 e lode, Università degli Studi di Firenze

POSIZIONI ACCADEMICHE ATTUALI E PRECEDENTI
2023–presente Ricercatore a tempo determinato di tipo B (SSD CHIM/08), Dipartimento NEUROFARBA, Università degli Studi di Firenze
2020–2023 Ricercatore a tempo determinato di tipo A (SSD CHIM/08), Dipartimento NEUROFARBA, Università degli Studi di Firenze
2017–2020 Assegni di ricerca, Supervisori: Prof. Claudiu T. Supuran, Prof.ssa Paola Gratteri, Dipartimento NEUROFARBA, Università degli Studi di Firenze

ATTIVITÀ DIDATTICA
2020–presente Docente del corso di Medicinal Chemistry (in lingua inglese), Corso di Laurea Magistrale in Advanced Molecular Sciences, Università di Firenze
2020–presente Docente del corso di Analisi dei Medicinali II, Corso di Laurea in Farmacia, Università di Firenze
2020–presente Docente del corso di Molecular Modeling in Medicinal Chemistry, Corsi di Laurea in Farmacia e Chimica e Tecnologia Farmaceutiche

ORGANIZZAZIONE DI CONVEGNI SCIENTIFICI
2017 Comitato organizzatore, “3rd Satellite Meeting on Carbonic Anhydrase”, Montecatini Terme, Italia
2022 Comitato organizzatore locale, “4th ISFMS: Biochemistry, Molecular Biology and Druggability of Proteins”, Firenze, Italia
2023 Presidente del comitato organizzatore, “12th International Conference on Carbonic Anhydrases”, Napoli, Italia

SUPERVISIONE DI STUDENTI E POST-DOC
2023–presente Supervisore di un assegnista di ricerca
2015–presente Supervisore/co-supervisore di oltre 30 studenti di Laurea Magistrale (Scuola di Scienze della Salute Umana) e co-supervisore di 2 dottorandi (Dipartimento NEUROFARBA, Università di Firenze)

RELATORIE A CONGRESSI INTERNAZIONALI
Invited speaker

Italian/Spanish-Portuguese Joint Meeting in Medicinal Chemistry, 2018, Palermo
Cost Action CM1407 – Early Career Investigators Meeting, 2019, Bruxelles, Belgio
3rd HA-CTion Meeting, 2021, Sesto Fiorentino, Italia
2nd Drug Discovery Conference, 2022, Riga, Lettonia
G4ME Perugia, 2024, Perugia, Italia
Keynote Speaker at ISFMS 2025 Kyoto, 2025, Giappone

Altre comunicazioni orali

3rd Satellite Meeting on Carbonic Anhydrase, 2017, Montecatini Terme, Italia
11th International Conference on Carbonic Anhydrases, 2018, Bucarest, Romania
4th Satellite Meeting on Carbonic Anhydrases, 2019, Parma, Italia
39° Congresso Nazionale SIF – Società Italiana di Farmacologia, 2019, Firenze, Italia
12th International Conference on Carbonic Anhydrases, 2023, Napoli, Italia
SYNC2024, 2024, Roma, Italia

PRODUZIONE SCIENTIFICA

273 articoli e review pubblicati su riviste peer-reviewed
14 capitoli di libro
Curatore della monografia scientifica: “Carbonic Anhydrases: Biochemistry and Pharmacology of an Evergreen Pharmaceutical Target”, Academic Press (Elsevier), 2019, pp. 560, ISBN 9780128164761
3 brevetti e 2 domande di brevetto

INDICATORI BIBLIOMETRICI
H-index (Scopus, Scholar): 48, 51
Citazioni (Scopus, Scholar): 7767, 8823

FINANZIAMENTI DI RICERCA

Responsabile scientifico: “MuTaG4L”, PRIN 2022, MIUR (2023–2025)
Co-Responsabile scientifico: “CUTESANA” – Bando di Ateneo UNIFI (2023–2025)
Membro dell’unità locale “FISR2019_04819 BacCAD” – MIUR, Fondo Integrativo Speciale per la Ricerca (2020–2023)
Membro dell’unità locale “Targeting di strutture G-quadruplex di acidi nucleici e anidrasi carbonica per lo sviluppo di strategie terapeutiche tumorali multibersaglio” – Fondazione Intesa San Paolo 2021 (2022)
Membro dell’unità locale “Springboard for excellence in advanced development of antibacterials” – Commissione Europea, Horizon 2020 (2020–2023)
Membro dell’unità locale “BETA3TUMPED: β3-adrenoreceptor as prognostic marker in Neuroblastoma and Ewing Sarcoma” – Bando Salute 2018 Regione Toscana (2020–2023)
Membro dell’unità locale “Tuscany Health Ecosystem (THE)”, Spoke 8 – PNRR (2022–2025)

PREMI E RICONOSCIMENTI
2018 Premio Miglior Tesi di Dottorato, Divisione di Chimica Farmaceutica, Società Chimica Italiana
2020 Premio Miglior Comunicazione Orale, IV Satellite Meeting on Carbonic Anhydrases 2019, Parma, Italia

ABILITAZIONE SCIENTIFICA NAZIONALE
2019 Abilitazione Scientifica Nazionale, Settore Concorsuale 03/D1 – II Fascia (valida dal 17/09/2019 al 17/09/2028)

Alessio NOCENTINI

Pubblicazioni

Legenda

Contributo su rivista |

Articolo su libro |

Libro |

Contributo in atti di convegno (proceeding) |

Brevetto |

Curatela | Altro

Altro |

Tesi di Dottorato

Vigiani, Erica; Bonardi, Alessandro; Catarzi, Daniela; Varano, Flavia; Calenda, Sara; Ceni, Costanza; Vagnoni, Giulia; Angeli, Andrea; Nocentini, Alessio; Gratteri, Paola; Supuran, Claudiu T.; Colotta, Vittoria (2025). Repurposing the amino-3,5-dicyanopyridine scaffold from adenosine receptor ligands to carbonic anhydrase activators. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 291, pp. 0-0, ISSN:0223-5234 DOI

Anastasija Balašova; Aleksandrs Pustenko; Andrea Angeli; Elena Andreucci; Alessio Biagioni; Alessio Nocentini; Fabrizio Carta; Claudiu T. Supuran; Raivis Žalubovskis (2025). Unraveling the Potential of Amino-, Acylamino-, and Ureido-Substituted 3H-1,2-Benzoxaphosphepine 2-Oxides toward Nanomolar Inhibitors of Tumor-Associated Carbonic Anhydrases IX and XII. ACS MEDICINAL CHEMISTRY LETTERS, pp. 0-0, ISSN:1948-5875 DOI

Claudiu Supuran, Alessio Nocentini (2024). Carbonic anhydrase inhibitors: Design, synthesis and bioevaluation fo new multi-target agents.. (Tutor: Prof. Claudiu T. Supuran, Dr. Alessio Nocentini)

Quagliata, M.; Brenzini Biagioni, F.; Giovannuzzi, S.; De Luca, V.; Capasso, C.; Nocentini, A.; Supuran, C. T.; Rovero, P.; Papini, A.M (2024). Synthesis, characterization and biological activity evaluation of a dual-drug based on the antibacterial peptide lugdunin functionalized with the Carbonic Anhydrase sulfonamide inhibitor acetazolamide. In: 37th European Peptide Symposium, The European Peptide Society, pp. 2083-2083. DOI

Giovannuzzi S.; Nikitjuka A.; Angeli A.; Smietana M.; Massardi M.-L.; Turati M.; Ronca R.; Bonardi A.; Nocentini A.; Ferraroni M.; Supuran C.T.; Winum J.-Y. (2024). Benzoxaborinine, New Chemotype for Carbonic Anhydrase Inhibition: Ex Novo Synthesis, Crystallography, In Silico Studies, and Anti-Melanoma Cell Line Activity. JOURNAL OF MEDICINAL CHEMISTRY, vol. 67, pp. 18221-18234, ISSN:1520-4804 DOI Accesso ONLINE all'editore

Emanuela Berrino; Bastien Michelet; Kassandra Vitse; Alessio Nocentini; Gianluca Bartolucci; Agnès Martin-Mingot; Paola Gratteri; Fabrizio Carta; Claudiu T. Supuran; Sébastien Thibaudeau (2024). Superacid-Synthesized Fluorinated Diamines Act as Selective hCA IV Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY, pp. 0-0, ISSN:0022-2623 DOI

Alessio Nocentini, Anna Di Porzio, Alessandro Bonardi, Carla Bazzicalupi, Andrea Petreni, Tarita Biver, Silvia Bua, Simona Marzano, Jussara Amato, Bruno Pagano, Nunzia Iaccarino, Stefano De Tito, Stefano Amente, Claudiu T. Supuran, Antonio Randazzo, Paola Gratteri (2024). Development of a multi-targeted chemotherapeutic approach based on G-quadruplex stabilisation and carbonic anhydrase inhibition. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, pp. 2366236-2366260, ISSN:1475-6374 DOI

De Luca, Viviana; Angeli, Andrea; Nocentini, Alessio; Gratteri, Paola; Pratesi, Silvia; Tanini, Damiano; Carginale, Vincenzo; Capperucci, Antonella; Supuran, Claudiu T.; Capasso, Clemente (2024). Leveraging SARS-CoV-2 Main Protease (Mpro) for COVID-19 Mitigation with Selenium-Based Inhibitors. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 25, pp. 0-0, ISSN:1422-0067 DOI

Fuentes-Aguilar, Alma; González-Bakker, Aday; Jovanović, Mirna; Stojanov, Sofija Jovanović; Puerta, Adrián; Gargano, Adriana; Dinić, Jelena; Vega-Báez, José L.; Merino-Montiel, Penélope; Montiel-Smith, Sara; Alcaro, Stefano; Nocentini, Alessio; Pešić, Milica; Supuran, Claudiu T.; Padrón, José M.; Fernández-Bolaños, José G.; López, Óscar (2024). Coumarins-lipophilic cations conjugates: Efficient mitocans targeting carbonic anhydrases. BIOORGANIC CHEMISTRY, vol. 145, pp. 0-0, ISSN:0045-2068 DOI

Tawfik, Haytham O.; Saleh, Mohamed M.; Ammara, Andrea; Khaleel, Eman F.; Badi, Rehab; Khater, Yomna T. T.; Rasheed, Rabab A.; Attia, Ahmed A.; Hefny, Salma M.; Elkaeed, Eslam B.; Nocentini, Alessio; Supuran, Claudiu T.; Eldehna, Wagdy M.; Shaldam, Moataz A. (2024). Discovery of Novel Pyridazine-Tethered Sulfonamides as Carbonic Anhydrase II Inhibitors for the Management of Glaucoma. JOURNAL OF MEDICINAL CHEMISTRY, vol. 67, pp. 1611-1623, ISSN:0022-2623 DOI

Giovannuzzi, Simone; Chavarria, Daniel; Provensi, Gustavo; Leri, Manuela; Bucciantini, Monica; Carradori, Simone; Bonardi, Alessandro; Gratteri, Paola; Borges, Fernanda; Nocentini, Alessio; Supuran, Claudiu T. (2024). Dual Inhibitors of Brain Carbonic Anhydrases and Monoamine Oxidase-B Efficiently Protect against Amyloid-β-Induced Neuronal Toxicity, Oxidative Stress, and Mitochondrial Dysfunction. JOURNAL OF MEDICINAL CHEMISTRY, vol. 67, pp. 4170-4193, ISSN:0022-2623 DOI

Braconi L.; Riganti C.; Parenti A.; Cecchi M.; Nocentini A.; Bartolucci G.; Menicatti M.; Contino M.; Colabufo N.A.; Manetti D.; Romanelli M.N.; Supuran C.T.; Teodori E. (2024). Dual Inhibitors of P-gp and Carbonic Anhydrase XII (hCA XII) against Tumor Multidrug Resistance with Piperazine Scaffold. MOLECULES, vol. 29, pp. 1-32, ISSN:1420-3049 DOI Accesso ONLINE all'editore

Giovannuzzi, Simone; Nikitjuka, Anna; Pereira Resende, Bruna Rafaela; Smietana, Michael; Nocentini, Alessio; Supuran, Claudiu T.; Winum, Jean-Yves (2024). Boron-containing carbonic anhydrases inhibitors. BIOORGANIC CHEMISTRY, vol. 143, pp. 0-0, ISSN:0045-2068 DOI

Bua, Silvia; Bonardi, Alessandro; Mük, Georgiana Ramona; Nocentini, Alessio; Gratteri, Paola; Supuran, Claudiu T. (2024). Benzothiadiazinone-1,1-Dioxide Carbonic Anhydrase Inhibitors Suppress the Growth of Drug-Resistant Mycobacterium tuberculosis Strains. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 25, pp. 0-0, ISSN:1422-0067 DOI

Huwaimel, Bader I; Jonnalagadda, Sravan K; Jonnalagadda, Shirisha; Kumari, Shikha; Nocentini, Alessio; Supuran, Claudiu T; Trippier, Paul C (2023). Selective carbonic anhydrase IX and XII inhibitors based around a functionalized coumarin scaffold. DRUG DEVELOPMENT RESEARCH, pp. 0-0, ISSN:0272-4391 DOI

Giovannuzzi, Simone; Bonardi, Alessandro; Gratteri, Paola; Nocentini, Alessio; Supuran, Claudiu T (2023). Discovery of the first-in-class potent and isoform-selective human carbonic anhydrase III inhibitors. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 38, pp. 0-0, ISSN:1475-6374 DOI

Nocentini, Alessio; Capasso, Clemente; Supuran, Claudiu T (2023). Carbonic Anhydrase Inhibitors as Novel Antibacterials in the Era of Antibiotic Resistance: Where Are We Now?. ANTIBIOTICS, vol. 12, pp. 0-0, ISSN:2079-6382 DOI

Ivanova, Jekaterina; Abdoli, Morteza; Nocentini, Alessio; Žalubovskis, Raivis; Supuran, Claudiu T (2023). 1,2,3-Benzoxathiazine-2,2-dioxides - effective inhibitors of human carbonic anhydrases. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 38, pp. 225-238, ISSN:1475-6366 DOI

Nocentini, Alessio; Bonardi, Alessandro; Bazzicalupi, Carla; Alterio, Vincenzo; Esposito, Davide; Monti, Simona Maria; Smietana, Michael; De Simone, Giuseppina; Supuran, Claudiu T; Gratteri, Paola; Winum, Jean-Yves (2023). 6-Substituted Triazolyl Benzoxaboroles as Selective Carbonic Anhydrase Inhibitors: In Silico Design, Synthesis, and X-ray Crystallography. JOURNAL OF MEDICINAL CHEMISTRY, vol. 66, pp. 8118-8129, ISSN:0022-2623 DOI Accesso ONLINE all'editore

Fiorentino, Francesco; Nocentini, Alessio; Rotili, Dante; Supuran, Claudiu T; Mai, Antonello (2023). Antihistamines, phenothiazine-based antipsychotics, and tricyclic antidepressants potently activate pharmacologically relevant human carbonic anhydrase isoforms II and VII. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 38, pp. 2188147-2188147, ISSN:1475-6374 DOI

Begines, Paloma; Bonardi, Alessandro; Nocentini, Alessio; Gratteri, Paola; Giovannuzzi, Simone; Ronca, Roberto; Tavani, Camilla; Luisa Massardi, Maria; López, Óscar; Supuran, Claudiu T (2023). Design and synthesis of sulfonamides incorporating a biotin moiety: Carbonic anhydrase inhibitory effects, antiproliferative activity and molecular modeling studies. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 94, pp. 117467-117482, ISSN:0968-0896 DOI

Fei L, Cantini G, Nocentini A, Nardini P, Catarinicchia S, Canu L, Ercolino T, Quartararo G, Nesi G, Gacci M, Maggi M, Hantel C, Mannelli M, Supuran CT, Luconi M (2023). Carbonic anhydrases III and IX are new players in the crosstalk between adrenocortical carcinoma and its altered adipose microenvironment. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, pp. 1-10, ISSN:0391-4097 DOI

Nocentini, Alessio; Capasso, Clemente; Supuran, Claudiu T. (2023). Bacterial Ectonucleotidases: Underexplored Antibacterial Drug Targets. In: Alessio Nocentini, Clemente Capasso, Claudiu T Supuran. Bacterial Ectonucleotidases: Underexplored Antibacterial Drug Targets, pp. 0-0 Springer. DOI

Capasso, Clemente; Nocentini, Alessio; Supuran, Claudiu T. (2023). CD73 Inhibitors as Antitumor Agents. In: Clemente Capasso, Alessio Nocentini, Claudiu T Supuran. Springer, pp. 0-0 Springer. DOI

Marapaka, Anil Kumar; Nocentini, Alessio; Youse, Molly S; An, Weiwei; Holly, Katrina J; Das, Chittaranjan; Yadav, Ravi; Seleem, Mohamed N; Supuran, Claudiu T; Flaherty, Daniel P (2023). Structural Characterization of Thiadiazolesulfonamide Inhibitors Bound to Neisseria gonorrhoeae α-Carbonic Anhydrase. ACS MEDICINAL CHEMISTRY LETTERS, vol. 14, pp. 103-109, ISSN:1948-5875 DOI

Eldehna, Wagdy M; El Hassab, Mahmoud A; Abdelshafi, Nahla A; Eissa, Rana A; Diab, Nadeen H; Mohamed, Ekram H; Oraby, Mamdouh A; Al-Rashood, Sara T; Eissa, Rana G; Elsayed, Zainab M; Nocentini, Alessio; Supuran, Claudiu T; Elsabahy, Mahmoud; Eissa, Noura G (2023). Development of potent nanosized carbonic anhydrase inhibitor for targeted therapy of hypoxic solid tumors. INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 631, pp. 122537-122537, ISSN:0378-5173 DOI

Angeli A.; Ferraroni M.; Bonardi A.; Supuran C.T.; Nocentini A. (2023). Diversely N-substituted benzenesulfonamides dissimilarly bind to human carbonic anhydrases: crystallographic investigations of N-nitrosulfonamides. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 38, pp. 2178430-2178430, ISSN:1475-6366 DOI

El-Damasy, Ashraf K; Kim, Hyun Ji; Nocentini, Alessio; Seo, Seon Hee; Eldehna, Wagdy M; Bang, Eun-Kyoung; Supuran, Claudiu T; Keum, Gyochang (2023). Discovery of new 6-ureido/amidocoumarins as highly potent and selective inhibitors for the tumour-relevant carbonic anhydrases IX and XII. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 38, pp. 2154603-2154603, ISSN:1475-6366 DOI

Ialongo, D; Messore, A; Madia, VN; Tudino, V; Nocentini, A; Gratteri, P; Giovannuzzi, S; Supuran, CT; Nicolai, A; Scarpa, S; Taurone, S; Camarda, M; Artico, M; Papa, V; Saccoliti, F; Scipione, L; Di Santo, R; Costi, R (2023). Pyrrolyl and Indolyl alpha-gamma-Diketo Acid Derivatives Acting as Selective Inhibitors of Human Carbonic Anhydrases IX and XII. PHARMACEUTICALS, vol. 16, pp. 188-188, ISSN:1424-8247 DOI

Cuffaro, Doretta; Di Leo, Riccardo; Ciccone, Lidia; Nocentini, Alessio; Supuran, Claudiu T; Nuti, Elisa; Rossello, Armando (2023). New isoxazolidinyl-based N-alkylethanolamines as new activators of human brain carbonic anhydrases. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 38, pp. 2164574-2164574, ISSN:1475-6366 DOI

Elsayed, Zainab M; Almahli, Hadia; Nocentini, Alessio; Ammara, Andrea; Supuran, Claudiu T; Eldehna, Wagdy M; Abou-Seri, Sahar M (2023). Development of novel anilinoquinazoline-based carboxylic acids as non-classical carbonic anhydrase IX and XII inhibitors. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 38, pp. 2191163-2191163, ISSN:1475-6366 DOI

El-Azab, Adel S.; A.-M. Abdel-Aziz, Alaa; Bua, Silvia; Nocentini, Alessio; Bakheit, Ahmed H.; Alkahtani, Hamad M.; Hefnawy, Mohamed M.; Supuran, Claudiu T. (2023). Design, synthesis, and carbonic anhydrase inhibition activities of Schiff bases incorporating benzenesulfonamide scaffold: Molecular docking application. SAUDI PHARMACEUTICAL JOURNAL, vol. 31, pp. 0-0, ISSN:1319-0164 DOI

Giovannuzzi, Simone; Marapaka, Anil Kumar; Abutaleb, Nader S.; Carta, Fabrizio; Liang, Hsin-Wen; Nocentini, Alessio; Pisano, Luigi; Seleem, Mohamed N.; Flaherty, Daniel P.; Supuran, Claudiu T. (2023). Inhibition of pathogenic bacterial carbonic anhydrases by monothiocarbamates. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 38, pp. 0-0, ISSN:1475-6366 DOI

Romagnoli, Romeo; De Ventura, Tiziano; Manfredini, Stefano; Baldini, Erika; Supuran, Claudiu T.; Nocentini, Alessio; Brancale, Andrea; Bortolozzi, Roberta; Manfreda, Lorenzo; Viola, Giampietro (2023). Design, synthesis, and biological investigation of selective human carbonic anhydrase II, IX, and XII inhibitors using 7-aryl/heteroaryl triazolopyrimidines bearing a sulfanilamide scaffold. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 38, pp. 0-0, ISSN:1475-6366 DOI

Saied, Samaa; Shaldam, Moataz; Elbadawi, Mostafa M.; Giovannuzzi, Simone; Nocentini, Alessio; Almahli, Hadia; Salem, Rofaida; Ibrahim, Tamer M.; Supuran, Claudiu T.; Eldehna, Wagdy M. (2023). Discovery of indolinone-bearing benzenesulfonamides as new dual carbonic anhydrase and VEGFR-2 inhibitors possessing anticancer and pro-apoptotic properties. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 259, pp. 0-0, ISSN:0223-5234 DOI

Elsawi, Ahmed E.; Elbadawi, Mostafa M.; Nocentini, Alessio; Almahli, Hadia; Giovannuzzi, Simone; Shaldam, Moataz; Salem, Rofaida; Ibrahim, Tamer M.; Abdel-Aziz, Hatem A.; Supuran, Claudiu T.; Eldehna, Wagdy M. (2023). 1,5-Diaryl-1,2,4-triazole Ureas as New SLC-0111 Analogues Endowed with Dual Carbonic Anhydrase and VEGFR-2 Inhibitory Activities. JOURNAL OF MEDICINAL CHEMISTRY, vol. 66, pp. 10558-10578, ISSN:0022-2623 DOI

Eldehna, Wagdy M.; Mohammed, Eslam E.; Al-Ansary, Ghada H.; Berrino, Emanuela; Elbadawi, Mostafa M.; Ibrahim, Tamer M.; Jaballah, Maiy Y.; Al-Rashood, Sara T.; Binjubair, Faizah A.; Celik, Meltem; Nocentini, Alessio; Elbarbry, Fawzy A.; Sahin, Fikrettin; Abdel-Aziz, Hatem A.; Supuran, Claudiu T.; Fares, Mohamed (2023). Design and synthesis of 6-arylpyridine-tethered sulfonamides as novel selective inhibitors of carbonic anhydrase IX with promising antitumor features toward the human colorectal cancer. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 258, pp. 0-0, ISSN:0223-5234 DOI

Masci, Domiziana; Puxeddu, Michela; Di Magno, Laura; D’Ambrosio, Michele; Parisi, Anastasia; Nalli, Marianna; Bai, Ruoli; Coluccia, Antonio; Sciò, Pietro; Orlando, Viviana; D’Angelo, Sara; Biagioni, Stefano; Urbani, Andrea; Hamel, Ernest; Nocentini, Alessio; Filiberti, Serena; Turati, Marta; Ronca, Roberto; Kopecka, Joanna; Riganti, Chiara; Fionda, Cinzia; Bordone, Rosa; Della Rocca, Giorgia; Canettieri, Gianluca; Supuran, Claudiu T.; Silvestri, Romano; La Regina, Giuseppe (2023). 4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/β-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells. JOURNAL OF MEDICINAL CHEMISTRY, vol. 66, pp. 14824-14842, ISSN:0022-2623 DOI

Balašova, Anastasija; Pustenko, Aleksandrs; Nocentini, Alessio; Vullo, Daniela; Supuran, Claudiu T.; Žalubovskis, Raivis (2023). Aryl derivatives of 3 H -1,2-benzoxaphosphepine 2-oxides as inhibitors of cancer-related carbonic anhydrase isoforms IX and XII. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 38, pp. 0-0, ISSN:1475-6366 DOI

Martínez-Montiel, Mónica; Romero-Hernández, Laura L; Giovannuzzi, Simone; Begines, Paloma; Puerta, Adrián; Ahuja-Casarín, Ana I; Fernandes, Miguel X; Merino-Montiel, Penélope; Montiel-Smith, Sara; Nocentini, Alessio; Padrón, José M; Supuran, Claudiu T; Fernández-Bolaños, José G; López, Óscar (2023). Conformationally Restricted Glycoconjugates Derived from Arylsulfonamides and Coumarins: New Families of Tumour-Associated Carbonic Anhydrase Inhibitors. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 24, pp. 0-0, ISSN:1422-0067 DOI

Ivanova, Jekateri Na; Nocentini, Alessio; Ta Rs, Kaspars; Leita Ns, Ja Nis; Dvinskis, Elviss; Kazaks, Andris; Domračeva, Ilona; Supuran, Claudiu T; Žalubovskis, Raivis (2023). Atropo/Tropo Flexibility: A Tool for Design and Synthesis of Self-Adaptable Inhibitors of Carbonic Anhydrases and Their Antiproliferative Effect. JOURNAL OF MEDICINAL CHEMISTRY, vol. 66, pp. 0-0, ISSN:1520-4804 DOI

Badawi, Waleed A; Rashed, Mahmoud; Nocentini, Alessio; Bonardi, Alessandro; Abd-Alhaseeb, Mohammad M; Al-Rashood, Sara T; Veerakanellore, Giri Babu; Majrashi, Taghreed A; Elkaeed, Eslam B; Elgendy, Bahaa; Gratteri, Paola; Supuran, Claudiu T; Eldehna, Wagdy M; Elagawany, Mohamed (2023). Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 38, pp. 0-0, ISSN:1475-6374 DOI Accesso ONLINE all'editore

Ragab, Mahmoud A; Eldehna, Wagdy M; Nocentini, Alessio; Bonardi, Alessandro; Okda, Hazem E; Elgendy, Bahaa; Ibrahim, Tarek S; Abd-Alhaseeb, Mohammad M; Gratteri, Paola; Supuran, Claudiu T; Al-Karmalawy, Ahmed A; Elagawany, Mohamed (2023). 4-(5-Amino-pyrazol-1-yl)benzenesulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and carbonic anhydrase: Design, synthesis, and biological assessments. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 250, pp. 115180-115180, ISSN:0223-5234 DOI

Ivanova, Jekaterīna; Abdoli, Morteza; Nocentini, Alessio; Žalubovskis, Raivis; Supuran, Claudiu T (2023). Derivatives of 4-methyl-1,2,3-benzoxathiazine 2,2-dioxide as selective inhibitors of human carbonic anhydrases IX and XII over the cytosolic isoforms I and II. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 38, pp. 0-0, ISSN:1475-6366 DOI

Beatriz Vermelho, Alane; Rodrigues, Giseli Capaci; Nocentini, Alessio; Mansoldo, Felipe R P; Supuran, Claudiu T (2022). Discovery of novel drugs for Chagas disease: is carbonic anhydrase a target for antiprotozoal drugs?. EXPERT OPINION ON DRUG DISCOVERY, vol. 17, pp. 1147-1158, ISSN:1746-045X DOI

Bonardi, Alessandro; Micheli, Laura; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Gratteri, Paola; Nocentini, Alessio; Supuran, Claudiu T (2022). Development of Hydrogen Sulfide-Releasing Carbonic Anhydrases IX- and XII-Selective Inhibitors with Enhanced Antihyperalgesic Action in a Rat Model of Arthritis. JOURNAL OF MEDICINAL CHEMISTRY, vol. 65, pp. 13143-13157, ISSN:1520-4804 DOI

Abo-Ashour, Mahmoud F; Almahli, Hadia; Bonardia, Alessandro; Khalil, Amira; Al-Warhi, Tarfah; Al-Rashood, Sara T; Abdel-Aziz, Hatem A; Nocentini, Alessio; Supuran, Claudiu T; Eldehna, Wagdy M (2022). Enaminone-based carboxylic acids as novel non-classical carbonic anhydrases inhibitors: design, synthesis and in vitro biological assessment. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 2256-2264, ISSN:1475-6374 DOI

Kalinin, Stanislav; Kovalenko, Alexander; Valtari, Annika; Nocentini, Alessio; Gureev, Maxim; Urtti, Arto; Korsakov, Mikhail; Supuran, Claudiu T; Krasavin, Mikhail (2022). 5-(Sulfamoyl)thien-2-yl 1,3-oxazole inhibitors of carbonic anhydrase II with hydrophilic periphery. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 1005-1011, ISSN:1475-6374 DOI

Arias, Hugo R; Borghese, Cecilia M; Germann, Allison L; Pierce, Spencer R; Bonardi, Alessandro; Nocentini, Alessio; Gratteri, Paola; Thodati, Thanvi M; Lim, Natalie J; Harris, R Adron; Akk, Gustav (2022). (+)-Catharanthine potentiates the GABAA receptor by binding to a transmembrane site at the β(+)/α(-) interface near the TM2-TM3 loop. BIOCHEMICAL PHARMACOLOGY, vol. 199, pp. 114993-114993, ISSN:1873-2968 DOI

Huwaimel, Bader I; Jonnalagadda, Sravan; Jonnalagadda, Shirisha; Zahra, Fatema T; Nocentini, Alessio; Supuran, Claudiu T; Mikelis, Constantinos M; Trippier, Paul C (2022). Chlorinated benzothiadiazines inhibit angiogenesis through suppression of VEGFR2 phosphorylation. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 67, pp. 116805-116805, ISSN:1464-3391 DOI

Yusuf, Zainab Saad; Uysal, Tugba Kevser; Simsek, Ender; Nocentini, Alessio; Osman, Sameh Mohamed; Supuran, Claudiu T; Özensoy Güler, Özen (2022). The inhibitory effect of boric acid on hypoxia-regulated tumour-associated carbonic anhydrase IX. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 1340-1345, ISSN:1475-6374 DOI

El-Azab, Adel S.; Abdel-Aziz, Alaa A.-M.; Ghabbour, Hazem A.; Bua, Silvia; Nocentini, Alessio; Alkahtani, Hamad M.; Alsaif, Nawaf A.; Al-Agamy, Mohamed H. M.; Supuran, Claudiu T. (2022). Carbonic Anhydrase Inhibition Activities of Schiff’s Bases Based on Quinazoline-Linked Benzenesulfonamide. MOLECULES, vol. 27, pp. 7703-7703, ISSN:1420-3049 DOI

An, Weiwei; Holly, Katrina J; Nocentini, Alessio; Imhoff, Ryan D; Hewitt, Chad S; Abutaleb, Nader S; Cao, Xufeng; Seleem, Mohamed N; Supuran, Claudiu T; Flaherty, Daniel P (2022). Structure-activity relationship studies for inhibitors for vancomycin-resistant Enterococcus and human carbonic anhydrases. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 1838-1844, ISSN:1475-6374 DOI

Gurgone, Antonia; Pizzo, Riccardo; Raspanti, Alessandra; Chiantia, Giuseppe; Devi, Sunaina; Comai, Debora; Morello, Noemi; Pilotto, Federica; Gnavi, Sara; Lupori, Leonardo; Mazziotti, Raffaele; Sagona, Giulia; Putignano, Elena; Nocentini, Alessio; Supuran, Claudiu T; Marcantoni, Andrea; Pizzorusso, Tommaso; Giustetto, Maurizio (2022). mGluR5 PAMs rescue cortical and behavioural defects in a mouse model of CDKL5 deficiency disorder. NEUROPSYCHOPHARMACOLOGY, pp. 0-0, ISSN:1740-634X DOI

Cirri, Damiano; Bazzicalupi, Carla; Ryde, Ulf; Bergmann, Justin; Binacchi, Francesca; Nocentini, Alessio; Pratesi, Alessandro; Gratteri, Paola; Messori, Luigi (2022). Computationally enhanced X-ray diffraction analysis of a gold(III) complex interacting with the human telomeric DNA G-quadruplex. Unravelling non-unique ligand positioning. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, vol. 211, pp. 506-513, ISSN:0141-8130 DOI

Pustenko, Aleksandrs; Balašova, Anastasija; Nocentini, Alessio; Supuran, Claudiu T.; Žalubovskis, Raivis (2022). 3H-1,2-Benzoxaphosphepine 2-oxides as selective inhibitors of carbonic anhydrase IX and XII. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 38, pp. 216-224, ISSN:1475-6366 DOI

Al-Warhi, Tarfah; Elbadawi, Mostafa M; Bonardi, Alessandro; Nocentini, Alessio; Al-Karmalawy, Ahmed A; Aljaeed, Nada; Alotaibi, Ohoud J; Abdel-Aziz, Hatem A; Supuran, Claudiu T; Eldehna, Wagdy M (2022). Design and synthesis of benzothiazole-based SLC-0111 analogues as new inhibitors for the cancer-associated carbonic anhydrase isoforms IX and XII. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 2635-2643, ISSN:1475-6374 DOI

Yrjanainen A.; Patrikainen M.S.; Azizi L.; Tolvanen M.E.E.; Laitaoja M.; Janis J.; Hytonen V.P.; Nocentini A.; Supuran C.T.; Parkkila S. (2022). Biochemical and Biophysical Characterization of Carbonic Anhydrase VI from Human Milk and Saliva. PROTEIN JOURNAL, vol. 41, pp. 489-503, ISSN:1572-3887 DOI

Di Fiore, Anna; De Luca, Viviana; Langella, Emma; Nocentini, Alessio; Buonanno, Martina; Monti, Simona Maria; Supuran, Claudiu T; Capasso, Clemente; De Simone, Giuseppina (2022). Biochemical, structural, and computational studies of a γ-carbonic anhydrase from the pathogenic bacterium Burkholderia pseudomallei. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, vol. 20, pp. 4185-4194, ISSN:2001-0370 DOI

Tawfik, Haytham O; Shaldam, Moataz A; Nocentini, Alessio; Salem, Rofaida; Almahli, Hadia; Al-Rashood, Sara T; Supuran, Claudiu T; Eldehna, Wagdy M (2022). Novel 3-(6-methylpyridin-2-yl)coumarin-based chalcones as selective inhibitors of cancer-related carbonic anhydrases IX and XII endowed with anti-proliferative activity. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 1043-1052, ISSN:1475-6374 DOI

Eldehna W.M.; Taghour M.S.; Al-Warhi T.; Nocentini A.; Elbadawi M.M.; Mahdy H.A.; Abdelrahman M.A.; Alotaibi O.J.; Aljaeed N.; Elimam D.M.; Afarinkia K.; Abdel-Aziz H.A.; Supuran C.T. (2022). Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 531-541, ISSN:1475-6366 DOI

Nocentini A.; Bonardi A.; Pratesi S.; Gratteri P.; Dani C.; Supuran C.T. (2022). Pharmaceutical strategies for preventing toxicity and promoting antioxidant and anti-inflammatory actions of bilirubin. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 487-501, ISSN:1475-6366 DOI Accesso ONLINE all'editore

Sbravati D.; Bonardi A.; Bua S.; Angeli A.; Ferraroni M.; Nocentini A.; Casnati A.; Gratteri P.; Sansone F.; Supuran C.T. (2022). Calixarenes Incorporating Sulfonamide Moieties: Versatile Ligands for Carbonic Anhydrases Inhibition. CHEMISTRY-A EUROPEAN JOURNAL, vol. 28, pp. 1-8, ISSN:0947-6539 DOI Accesso ONLINE all'editore

Elimam D.M.; Eldehna W.M.; Salem R.; Bonardi A.; Nocentini A.; Al-Rashood S.T.; Elaasser M.M.; Gratteri P.; Supuran C.T.; Allam H.A. (2022). Natural inspired ligustrazine-based SLC-0111 analogues as novel carbonic anhydrase inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 228, pp. 114008-114019, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Chiaramonte N.; Angeli A.; Sgambellone S.; Bonardi A.; Nocentini A.; Bartolucci G.; Braconi L.; Dei S.; Lucarini L.; Teodori E.; Gratteri P.; Wunsch B.; Supuran C.T.; Romanelli M.N. (2022). 2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 228, pp. 0-0, ISSN:0223-5234 DOI

Giovannuzzi S.; D'ambrosio M.; Luceri C.; Osman S.M.; Pallecchi M.; Bartolucci G.; Nocentini A.; Supuran C.T. (2022). Aromatic sulfonamides including a sulfonic acid tail: New membrane impermeant carbonic anhydrase inhibitors for targeting selectively the cancer‐associated isoforms. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, pp. 0-0, ISSN:1422-0067 DOI

Ismail C.; Nocentini A.; Supuran C.T.; Winum J.-Y.; Gharbi R. (2022). 1,5-Benzodiazepines as a platform for the design of carbonic anhydrase inhibitors. ARCHIV DER PHARMAZIE, vol. 355, pp. e2100405-e2100405, ISSN:0365-6233 DOI

Mussi S.; Rezzola S.; Chiodelli P.; Nocentini A.; Supuran C.T.; Ronca R. (2022). Antiproliferative effects of sulphonamide carbonic anhydrase inhibitors C18, SLC-0111 and acetazolamide on bladder, glioblastoma and pancreatic cancer cell lines. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 280-286, ISSN:1475-6366 DOI

Sharonova, Tatiana; Zhmurov, Petr; Kalinin, Stanislav; Nocentini, Alessio; Angeli, Andrea; Ferraroni, Marta; Korsakov, Mikhail; Supuran, Claudiu T; Krasavin, Mikhail (2022). Diversely substituted sulfamides for fragment-based drug discovery of carbonic anhydrase inhibitors: synthesis and inhibitory profile. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 857-865-865, ISSN:1475-6366 DOI

Fuentes-Aguilar A.; Merino-Montiel P.; Montiel-Smith S.; Meza-Reyes S.; Vega-Baez J.L.; Puerta A.; Fernandes M.X.; Padron J.M.; Petreni A.; Nocentini A.; Supuran C.T.; Lopez O.; Fernandez-Bolanos J.G. (2022). 2-Aminobenzoxazole-appended coumarins as potent and selective inhibitors of tumour-associated carbonic anhydrases. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 168-177, ISSN:1475-6366 DOI

Abutaleb N.S.; Elhassanny A.E.M.; Nocentini A.; Hewitt C.S.; Elkashif A.; Cooper B.R.; Supuran C.T.; Seleem M.N.; Flaherty D.P. (2022). Repurposing FDA-approved sulphonamide carbonic anhydrase inhibitors for treatment of Neisseria gonorrhoeae. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 51-61, ISSN:1475-6366 DOI

Giovannuzzi S.; Abutaleb N.S.; Hewitt C.S.; Carta F.; Nocentini A.; Seleem M.N.; Flaherty D.P.; Supuran C.T. (2022). Dithiocarbamates effectively inhibit the α-carbonic anhydrase from Neisseria gonorrhoeae. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 1-8, ISSN:1475-6366 DOI

Merabti A.; Roger M.; Nguyen C.; Nocentini A.; Gerbier P.; Richeter S.; Gary-Bobo M.; Supuran C.T.; Clement S.; Winum J.-Y. (2022). Carbonic Anhydrase Inhibitors Featuring a Porphyrin Scaffold: Synthesis, Optical and Biological Properties. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, pp. ---, ISSN:1434-193X DOI

Giovannuzzi S.; De Luca V.; Nocentini A.; Capasso C.; Supuran C.T. (2022). Coumarins inhibit η-class carbonic anhydrase from Plasmodium falciparum. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 680-685, ISSN:1475-6366 DOI

Bonardi, Alessandro; Bua, Silvia; Combs, Jacob; Lomelino, Carrie; Andring, Jacob; Osman, Sameh Mohamed; Toti, Alessandra; Di Cesare Mannelli, Lorenzo; Gratteri, Paola; Ghelardini, Carla; McKenna, Robert; Nocentini, Alessio; Supuran, Claudiu T (2022). The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 930-939-939, ISSN:1475-6366 DOI

Giovannuzzi S.; Hewitt C.S.; Nocentini A.; Capasso C.; Flaherty D.P.; Supuran C.T. (2022). Coumarins effectively inhibit bacterial α-carbonic anhydrases. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 333-338, ISSN:1475-6366 DOI

Giovannuzzi S.; Hewitt C.S.; Nocentini A.; Capasso C.; Costantino G.; Flaherty D.P.; Supuran C.T. (2022). Inhibition studies of bacterial α-carbonic anhydrases with phenols. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 666-671, ISSN:1475-6366 DOI

Nocentini, Alessio; Capasso, Clemente; Supuran, Claudiu T (2022). Perspectives on the design and discovery of α-ketoamide inhibitors for the treatment of novel coronavirus: where do we stand and where do we go?. EXPERT OPINION ON DRUG DISCOVERY, pp. 1-11-11, ISSN:1746-0441 DOI

Braconi, Laura; Teodori, Elisabetta; Riganti, Chiara; Coronnello, Marcella; Nocentini, Alessio; Bartolucci, Gian Luca; Pallecchi, Marco; Contino, Marialessandra; Manetti, Dina; Romanelli, Maria Novella; Supuran, Claudiu T; Dei, Silvia (2022). New dual P-Glycoprotein (P-gp) and human carbonic anhydrase XII (hCA XII) inhibitors as Multidrug Resistance (MDR) reversers in cancer cells. JOURNAL OF MEDICINAL CHEMISTRY, vol. 65, pp. 14655-14672, ISSN:0022-2623 DOI Accesso ONLINE all'editore

Kumar R.; Kumar A.; Ram S.; Angeli A.; Bonardi A.; Nocentini A.; Gratteri P.; Supuran C.T.; Sharma P.K. (2022). Novel benzenesulfonamide-bearing pyrazoles and 1,2,4-thiadiazoles as selective carbonic anhydrase inhibitors. ARCHIV DER PHARMAZIE, vol. 355, pp. e2100241-e2100241, ISSN:0365-6233 DOI Accesso ONLINE all'editore

Arrighi, Giulia; Puerta, Adrián; Petrini, Andrea; Hicke, Francisco J; Nocentini, Alessio; Fernandes, Miguel X; Padrón, José M; Supuran, Claudiu T; Fernández-Bolaños, José G; López, Óscar (2022). Squaramide-Tethered Sulfonamides and Coumarins: Synthesis, Inhibition of Tumor-Associated CAs IX and XII and Docking Simulations. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, pp. 7685-7685, ISSN:1422-0067 DOI

Mostafa M. Elbadawi; Wagdy M. Eldehna; Alessio Nocentini; Warda R. Somaa; Sara T. Al-Rashood; Eslam B. Elkaeed; Mahmoud A. El Hassab; Hatem A. Abdel-Aziz; Claudiu T. Supuran; Mohamed Fares (2022). Development of 4-((3-oxo-3-phenylpropyl)amino)benzenesulfonamide derivatives utilizing tail/dual-tail approaches as novel carbonic anhydrase inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 238, pp. 114412-114412, ISSN:0223-5234 DOI

Bonardi, Alessandro; Supuran, Claudiu T.; Nocentini, Alessio (2022). Phenols and Polyphenols as Carbonic Anhydrase Inhibitors. In: Alessandro Bonardi, Claudiu T Supuran, Alessio Nocentini. Phenols and Polyphenols as Carbonic Anhydrase Inhibitors, pp. 330-383 Bentham, ISBN:9789815079098. DOI

Giovannuzzi, Simone; Capasso, Clemente; Nocentini, Alessio; Supuran, Claudiu T (2022). Continued Structural Exploration of Sulfocoumarin as Selective Inhibitor of Tumor-Associated Human Carbonic Anhydrases IX and XII. MOLECULES, vol. 27, pp. 4076-4076, ISSN:1420-3049 DOI

Ibrahim, Hany S; Abdelrahman, Mohamed A; Nocentini, Alessio; Bua, Silvia; Abdel-Aziz, Hatem A; Supuran, Claudiu T; Abou-Seri, Sahar M; Eldehna, Wagdy M (2022). Insights into the effect of elaborating coumarin-based aryl enaminones with sulfonamide or carboxylic acid functionality on carbonic anhydrase inhibitory potency and selectivity. BIOORGANIC CHEMISTRY, vol. 126, pp. 105888-105888, ISSN:0045-2068 DOI

Lucarini E., Nocentini A., Bonardi A., Chiaramonte N., Parisio C., Micheli L., Toti A., Ferrara V., Carrino D., Pacini A., Romanelli M.N., Supuran C.T., Ghelardini C., Di Cesare Mannelli L. (2021). Carbonic Anhydrase IV Selective Inhibitors Counteract the Development of Colitis-Associated Visceral Pain in Rats. CELLS, vol. 10, pp. 2540-2555, ISSN:2073-4409 DOI

Abdelrahman M.A.; Ibrahim H.S.; Nocentini A.; Eldehna W.M.; Bonardi A.; Abdel-Aziz H.A.; Gratteri P.; Abou-Seri S.M.; Supuran C.T. (2021). Novel 3-substituted coumarins as selective human carbonic anhydrase IX and XII inhibitors: Synthesis, biological and molecular dynamics analysis. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 209, pp. 0-0, ISSN:0223-5234 DOI

Mincione F.; Nocentini A.; Supuran C.T. (2021). Advances in the discovery of novel agents for the treatment of glaucoma. EXPERT OPINION ON DRUG DISCOVERY, vol. 16, pp. 1209-1225, ISSN:1746-0441 DOI

De Luca V.; Petreni A.; Nocentini A.; Scaloni A.; Supuran C.T.; Capasso C. (2021). Effect of sulfonamides and their structurally related derivatives on the activity of ι-carbonic anhydrase from burkholderia territorii. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, pp. 1-13, ISSN:1661-6596 DOI

Nocentini A.; Cuffaro D.; Ciccone L.; Orlandini E.; Nencetti S.; Nuti E.; Rossello A.; Supuran C.T. (2021). Activation of carbonic anhydrases from human brain by amino alcohol oxime ethers: towards human carbonic anhydrase VII selective activators. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 36, pp. 48-57, ISSN:1475-6366 DOI

Nocentini, Alessio; Angeli, Andrea; Carta, Fabrizio; Winum, Jean-Yves; Zalubovskis, Raivis; Carradori, Simone; Capasso, Clemente; Donald, William A; Supuran, Claudiu T (2021). Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 36, pp. 561-580, ISSN:1475-6366 DOI

Grande R.; Carradori S.; Puca V.; Vitale I.; Angeli A.; Nocentini A.; Bonardi A.; Gratteri P.; Lanuti P.; Bologna G.; Simeone P.; Capasso C.; De Luca V.; Supuran C.T. (2021). Selective inhibition of helicobacter pylori carbonic anhydrases by carvacrol and thymol could impair biofilm production and the release of outer membrane vesicles. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, pp. 11583-11603, ISSN:1661-6596 DOI Accesso ONLINE all'editore

Hewitt C.S.; Abutaleb N.S.; Elhassanny A.E.M.; Nocentini A.; Cao X.; Amos D.P.; Youse M.S.; Holly K.J.; Marapaka A.K.; An W.; Kaur J.; Krabill A.D.; Elkashif A.; Elgammal Y.; Graboski A.L.; Supuran C.T.; Seleem M.N.; Flaherty D.P. (2021). Structure-Activity Relationship Studies of Acetazolamide-Based Carbonic Anhydrase Inhibitors with Activity against Neisseria gonorrhoeae. ACS INFECTIOUS DISEASES, vol. 7, pp. 1969-1984, ISSN:2373-8227 DOI

Elimam D.M.; Elgazar A.A.; Bonardi A.; Abdelfadil M.; Nocentini A.; El-Domany R.A.; Abdel-Aziz H.A.; Badria F.A.; Supuran C.T.; Eldehna W.M. (2021). Natural inspired piperine-based sulfonamides and carboxylic acids as carbonic anhydrase inhibitors: Design, synthesis and biological evaluation. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 225, pp. 113800--, ISSN:0223-5234 DOI

Sharonova T.; Paramonova P.; Kalinin S.; Bunev A.; Gasanov R.Е.; Nocentini A.; Sharoyko V.; Tennikova T.B.; Dar'in D.; Supuran C.T.; Krasavin M. (2021). Insertion of metal carbenes into the anilinic N–H bond of unprotected aminobenzenesulfonamides delivers low nanomolar inhibitors of human carbonic anhydrase IX and XII isoforms. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 218, pp. 113352--, ISSN:0223-5234 DOI

Alterio V.; Langella E.; Buonanno M.; Esposito D.; Nocentini A.; Berrino E.; Bua S.; Polentarutti M.; Supuran C.T.; Monti S.M.; De Simone G. (2021). Zeta-carbonic anhydrases show CS2 hydrolase activity: A new metabolic carbon acquisition pathway in diatoms?. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, vol. 19, pp. 3427-3436, ISSN:2001-0370 DOI

Petreni A.; Osman S.M.; Alasmary F.A.; Almutairi T.M.; Nocentini A.; Supuran C.T. (2021). Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 226, pp. 113875--, ISSN:0223-5234 DOI

Biernacki K.; Ciupak O.; Dasko M.; Rachon J.; Kozak W.; Rak J.; Kubinski K.; Maslyk M.; Martyna A.; Sliwka-Kaszynska M.; Wietrzyk J.; Switalska M.; Nocentini A.; Supuran C.T.; Demkowicz S. (2021). Development of Sulfamoylated 4-(1-Phenyl-1 H-1,2,3-triazol-4-yl)phenol Derivatives as Potent Steroid Sulfatase Inhibitors for Efficient Treatment of Breast Cancer. JOURNAL OF MEDICINAL CHEMISTRY, vol. 65, pp. 5044-5056, ISSN:0022-2623 DOI

Odi R.; Bibi D.; Shusterman B.; Erenburg N.; Shaul C.; Supuran C.T.; Nocentini A.; Bialer M. (2021). Synthesis and enantioselective pharmacokinetic/ pharmacodynamic analysis of new CNS-active sulfamoylphenyl carbamate derivatives. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, pp. 3361--, ISSN:1661-6596 DOI

Nocentini A.; Hewitt C.S.; Mastrolorenzo M.D.; Flaherty D.P.; Supuran C.T. (2021). Anion inhibition studies of the α-carbonic anhydrases from Neisseria gonorrhoeae. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 36, pp. 1061-1066, ISSN:1475-6366 DOI

Petreni A.; De Luca V.; Scaloni A.; Nocentini A.; Capasso C.; Supuran C.T. (2021). Anion inhibition studies of the Zn(II)-bound ι-carbonic anhydrase from the Gram-negative bacterium Burkholderia territorii. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 36, pp. 372-376, ISSN:1475-6366 DOI

Shaldam M.; Nocentini A.; Elsayed Z.M.; Ibrahim T.M.; Salem R.; El-Domany R.A.; Capasso C.; Supuran C.T.; Eldehna W.M. (2021). Development of novel quinoline-based sulfonamides as selective cancer-associated carbonic anhydrase isoform ix inhibitors. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, pp. 1-16, ISSN:1422-0067 DOI

Capasso C.; Nocentini A.; Supuran C.T. (2021). Protease inhibitors targeting the main protease and papain-like protease of coronaviruses. EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 31, pp. 309-324, ISSN:1354-3776 DOI

Nocentini A.; Capasso C.; Supuran C.T. (2021). Small-molecule CD73 inhibitors for the immunotherapy of cancer: a patent and literature review (2017–present). EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 31, pp. 867-876, ISSN:1354-3776 DOI

Luchinat, Enrico; Barbieri, Letizia; Cremonini, Matteo; Pennestri, Matteo; Nocentini, Alessio; Supuran, Claudiu T; Banci, Lucia (2021). Determination of intracellular protein-ligand binding affinity by competition binding in-cell NMR. ACTA CRYSTALLOGRAPHICA. SECTION D, STRUCTURAL BIOLOGY, vol. 77, pp. 1270-1281, ISSN:2059-7983 DOI Accesso ONLINE all'editore

Shaldam M.; Eldehna W.M.; Nocentini A.; Elsayed Z.M.; Ibrahim T.M.; Salem R.; El-Domany R.A.; Capasso C.; Abdel-Aziz H.A.; Supuran C.T. (2021). Development of novel benzofuran-based SLC-0111 analogs as selective cancer-associated carbonic anhydrase isoform IX inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 216, pp. 113283--, ISSN:0223-5234 DOI

Mueller S.L.; Chrysanthopoulos P.K.; Halili M.A.; Hepburn C.; Nebl T.; Supuran C.T.; Nocentini A.; Peat T.S.; Poulsen S.-A. (2021). The glitazone class of drugs as carbonic anhydrase inhibitors—a spin-off discovery from fragment screening. MOLECULES, vol. 26, pp. 3010--, ISSN:1420-3049 DOI

Eldeeb A.H.; Abo-Ashour M.F.; Angeli A.; Bonardi A.; Lasheen D.S.; Elrazaz E.Z.; Nocentini A.; Gratteri P.; Abdel-Aziz H.A.; Supuran C.T. (2021). Novel benzenesulfonamides aryl and arylsulfone conjugates adopting tail/dual tail approaches: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 221, pp. 113486-113509, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Bonardi A.; Nocentini A.; Osman S.M.; Alasmary F.A.; Almutairi T.M.; Abdullah D.S.; Gratteri P.; Supuran C.T. (2021). Inhibition of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae with aromatic sulphonamides and clinically licenced drugs–a joint docking/molecular dynamics study. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 36, pp. 469-479, ISSN:1475-6366 DOI Accesso ONLINE all'editore

Nocentini A.; Supuran C.T.; Capasso C. (2021). An overview on the recently discovered iota-carbonic anhydrases. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 36, pp. 1988-1995, ISSN:1475-6366 DOI

Angeli A.; Carta F.; Nocentini A.; Winum J.-Y.; Zalubovskis R.; Onnis V.; Eldehna W.M.; Capasso C.; Carradori S.; Donald W.A.; Dedhar S.; Supuran C.T. (2021). Response to Perspectives on the Classical Enzyme Carbonic Anhydrase and the Search for Inhibitors. BIOPHYSICAL JOURNAL, vol. 120, pp. 178-181, ISSN:0006-3495 DOI

Elbadawi M.M.; Eldehna W.M.; Nocentini A.; Abo-Ashour M.F.; Elkaeed E.B.; Abdelgawad M.A.; Alharbi K.S.; Abdel-Aziz H.A.; Supuran C.T.; Gratteri P.; Al-Sanea M.M. (2021). Identification of N-phenyl-2-(phenylsulfonyl)acetamides/propanamides as new SLC-0111 analogues: Synthesis and evaluation of the carbonic anhydrase inhibitory activities. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 218, pp. 113360-113371, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Nocentini, Alessio; Fais, Stefano (2021). Proton pump inhibitors and other pH-buffering agents. In: Claudiu T. Supuran, Simone Carradori. pH-Interfering Agents as Chemosensitizers in Cancer Therapy, pp. 47-62 Elsevier, ISBN:9780128207017. DOI

Nocentini, Alessio; Vermelho, Alane B.; Supuran, Claudiu T. (2021). Targeting Carbonic Anhydrases from Trypanosoma cruzi and Leishmania spp. as a Therapeutic Strategy to Obtain New Antiprotozoal Drugs. In: Alane B. Vermelho, Claudiu T. Supuran. Topics in Medicinal Chemistry, pp. 1-29 Springer. DOI

Gustavo Provensi; Alessio Nocentini; Maria Beatrice Passani; Patrizio Blandina; Claudiu T Supuran (2021). Activation of carbonic anhydrase isoforms involved in modulation of emotional memory and cognitive disorders with histamine agonists, antagonists and derivatives. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 36, pp. 719-726, ISSN:1475-6374 DOI

Bulli I.; Dettori I.; Coppi E.; Cherchi F.; Venturini M.; Mannelli L.D.C.; Ghelardini C.; Nocentini A.; Supuran C.T.; Pugliese A.M.; Pedata F. (2021). Role of carbonic anhydrase in cerebral ischemia and carbonic anhydrase inhibitors as putative protective agents. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, pp. 5029-5038, ISSN:1661-6596 DOI

Dettori I.; Fusco I.; Bulli I.; Gaviano L.; Coppi E.; Cherchi F.; Venturini M.; Di Cesare Mannelli L.; Ghelardini C.; Nocentini A.; Supuran C.T.; Pugliese A.M.; Pedata F. (2021). Protective effects of carbonic anhydrase inhibition in brain ischaemia in vitro and in vivo models. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 36, pp. 964-976, ISSN:1475-6366 DOI

Dar'in D.; Kantin G.; Kalinin S.; Sharonova T.; Bunev A.; Ostapenko G.I.; Nocentini A.; Sharoyko V.; Supuran C.T.; Krasavin M. (2021). Investigation of 3-sulfamoyl coumarins against cancer-related IX and XII isoforms of human carbonic anhydrase as well as cancer cells leads to the discovery of 2-oxo-2H-benzo[h]chromene-3-sulfonamide – A new caspase-activating proapoptotic agent. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 222, pp. 113589--, ISSN:0223-5234 DOI

Supuran C.T.; Nocentini A.; Yakubova E.; Savchuk N.; Kalinin S.; Krasavin M. (2021). Biochemical profiling of anti-HIV prodrug Elsulfavirine (Elpida®) and its active form VM1500A against a panel of twelve human carbonic anhydrase isoforms. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 36, pp. 1056-1060, ISSN:1475-6366 DOI

Bouzina A.; Berredjem M.; Nocentini A.; Bua S.; Bouaziz Z.; Jose J.; Le Borgne M.; Marminon C.; Gratteri P.; Supuran C.T. (2021). Ninhydrins inhibit carbonic anhydrases directly binding to the metal ion. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 209, pp. 112875-112882, ISSN:0223-5234 DOI

Yassine Aimene; Romain Eychenne; Fr??d??ric Rodriguez; Sonia Mallet-Ladeira; Nathalie Saffon-Merceron; Jean-Yves Winum; Alessio Nocentini; Claudiu T. Supuran; Eric Benoist; Achour Seridi (2021). Synthesis, Crystal Structure, Inhibitory Activity and Molecular Docking of Coumarins/Sulfonamides Containing Triazolyl Pyridine Moiety as Potent Selective Carbonic Anhydrase IX and XII Inhibitors. CRYSTALS, vol. 11, pp. 1076-1076, ISSN:2073-4352 DOI

Said M.A.; Eldehna W.M.; Nocentini A.; Bonardi A.; Fahim S.H.; Bua S.; Soliman D.H.; Abdel-Aziz H.A.; Gratteri P.; Abou-Seri S.M.; Supuran C.T. (2020). Synthesis, biological and molecular dynamics investigations with a series of triazolopyrimidine/triazole-based benzenesulfonamides as novel carbonic anhydrase inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 185, pp. 1-13, ISSN:0223-5234 DOI

Pustenko A.; Nocentini A.; Gratteri P.; Bonardi A.; Vozny I.; Zalubovskis R.; Supuran C.T. (2020). The antibiotic furagin and its derivatives are isoform-selective human carbonic anhydrase inhibitors. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 1011-1020, ISSN:1475-6366 DOI

Said M.A.; Eldehna W.M.; Nocentini A.; Fahim S.H.; Bonardi A.; Elgazar A.A.; Krystof V.; Soliman D.H.; Abdel-Aziz H.A.; Gratteri P.; Abou-Seri S.M.; Supuran C.T. (2020). Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 189, pp. 1-14, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Hargunani P.; Tadge N.; Ceruso M.; Leitans J.; Kazaks A.; Tars K.; Gratteri P.; Supuran C.T.; Nocentini A.; Toraskar M.P. (2020). Aryl-4,5-dihydro-1H-pyrazole-1-carboxamide derivatives bearing a sulfonamide moiety show single-digit nanomolar-to-subnanomolar inhibition constants against the tumor-associated human carbonic anhydrases IX and XII. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, pp. 1-11, ISSN:1661-6596 DOI

Angeli A.; Carta F.; Nocentini A.; Winum J.-Y.; Zalubovskis R.; Akdemir A.; Onnis V.; Eldehna W.M.; Capasso C.; Simone G.D.; Monti S.M.; Carradori S.; Donald W.A.; Dedhar S.; Supuran C.T. (2020). Carbonic anhydrase inhibitors targeting metabolism and tumor microenvironment. METABOLITES, vol. 10, pp. 1-21, ISSN:2218-1989 DOI

Fares, Mohamed; Eldehna, Wagdy M; Bua, Silvia; Lanzi, Cecilia; Lucarini, Laura; Masini, Emanuela; Peat, Thomas S; Abdel-Aziz, Hatem A; Nocentini, Alessio; Keller, Paul A; Supuran, Claudiu T (2020). Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action. JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, pp. 3317-3326, ISSN:1520-4804 DOI

Moi D.; Nocentini A.; Deplano A.; Osman S.M.; AlOthman Z.A.; Piras V.; Balboni G.; Supuran C.T.; Onnis V. (2020). Appliance of the piperidinyl-hydrazidoureido linker to benzenesulfonamide compounds: Synthesis, in vitro and in silico evaluation of potent carbonic anhydrase II, IX and XII inhibitors. BIOORGANIC CHEMISTRY, vol. 98, pp. 103728--, ISSN:0045-2068 DOI

Grandane A.; Nocentini A.; Domraceva I.; Zalubovskis R.; Supuran C.T. (2020). Development of oxathiino[6,5-b]pyridine 2,2-dioxide derivatives as selective inhibitors of tumor-related carbonic anhydrases IX and XII. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 200, pp. 112300--, ISSN:0223-5234 DOI

Nocentini A.; Del Prete S.; Mastrolorenzo M.D.; Donald W.A.; Capasso C.; Supuran C.T. (2020). Activation studies of the β-carbonic anhydrases from Escherichia coli with amino acids and amines. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 1379-1386, ISSN:1475-6366 DOI

Zoppi C.; Nocentini A.; Supuran C.T.; Pratesi A.; Messori L. (2020). Native mass spectrometry of human carbonic anhydrase I and its inhibitor complexes. JBIC, pp. 1-15, ISSN:0949-8257 DOI

Jin S.; Vullo D.; Bua S.; Nocentini A.; Supuran C.T.; Gao Y.-G. (2020). Structural and biochemical characterization of novel carbonic anhydrases from Phaeodactylum tricornutum Jin Shengyang. ACTA CRYSTALLOGRAPHICA. SECTION D, STRUCTURAL BIOLOGY, vol. 76, pp. 676-686, ISSN:2059-7983 DOI

Petreni A.; Bonardi A.; Lomelino C.; Osman S.M.; ALOthman Z.A.; Eldehna W.M.; El-Haggar R.; McKenna R.; Nocentini A.; Supuran C.T. (2020). Inclusion of a 5-fluorouracil moiety in nitrogenous bases derivatives as human carbonic anhydrase IX and XII inhibitors produced a targeted action against MDA-MB-231 and T47D breast cancer cells. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 190, pp. 112112--, ISSN:0223-5234 DOI

Grandane A.; Nocentini A.; Werner T.; Zalubovskis R.; Supuran C.T. (2020). Benzoxepinones: A new isoform-selective class of tumor associated carbonic anhydrase inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 28, pp. 115496--, ISSN:0968-0896 DOI

Nocentini A.; Moi D.; Deplano A.; Osman S.M.; AlOthman Z.A.; Balboni G.; Supuran C.T.; Onnis V. (2020). Sulfonamide/sulfamate switch with a series of piperazinylureido derivatives: Synthesis, kinetic and in silico evaluation as carbonic anhydrase isoforms I, II, IV, and IX inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 186, pp. 111896--, ISSN:0223-5234 DOI

El-Azab A.S.; Abdel-Aziz A.A.-M.; Bua S.; Nocentini A.; AlSaif N.A.; Alanazi M.M.; El-Gendy M.A.; Ahmed H.E.A.; Supuran C.T. (2020). S-substituted 2-mercaptoquinazolin-4(3H)-one and 4-ethylbenzensulfonamides act as potent and selective human carbonic anhydrase IX and XII inhibitors. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 733-743, ISSN:1475-6366 DOI

Alissa S.A.; Alghulikah H.A.; ALOthman Z.A.; Osman S.M.; Del Prete S.; Capasso C.; Nocentini A.; Supuran C.T. (2020). Inhibition survey with phenolic compounds against the δ- and η-class carbonic anhydrases from the marine diatom thalassiosira weissflogii and protozoan Plasmodium falciparum. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 377-382, ISSN:1475-6366 DOI

Abdelrahman M.A.; Eldehna W.M.; Nocentini A.; Ibrahim H.S.; Almahli H.; Abdel-Aziz H.A.; Abou-Seri S.M.; Supuran C.T. (2020). Novel benzofuran-based sulphonamides as selective carbonic anhydrases IX and XII inhibitors: synthesis and in vitro biological evaluation. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 298-305, ISSN:1475-6366 DOI

Irfan A.; Batool F.; Zahra Naqvi S.A.; Islam A.; Osman S.M.; Nocentini A.; Alissa S.A.; Supuran C.T. (2020). Benzothiazole derivatives as anticancer agents. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 265-279, ISSN:1475-6366 DOI

Del Prete S.; Nocentini A.; Supuran C.T.; Capasso C. (2020). Bacterial ι-carbonic anhydrase: a new active class of carbonic anhydrase identified in the genome of the Gram-negative bacterium Burkholderia territorii. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 1060-1068, ISSN:1475-6366 DOI

Oguz M.; Kalay E.; Akocak S.; Nocentini A.; Lolak N.; Boga M.; Yilmaz M.; Supuran C.T. (2020). Synthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory action. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 1215-1223, ISSN:1475-6366 DOI

Anduran E.; Aspatwar A.; Parvathaneni N.-K.; Suylen D.; Bua S.; Nocentini A.; Parkkila S.; Supuran C.T.; Dubois L.; Lambin P.; Winum J.-Y. (2020). Hypoxia-activated prodrug derivatives of carbonic anhydrase inhibitors in benzenesulfonamide series: Synthesis and biological evaluation. MOLECULES, vol. 25, pp. 2347--, ISSN:1420-3049 DOI

Prete S.D.; De Luca V.; Bua S.; Nocentini A.; Carginale V.; Supuran C.T.; Capasso C. (2020). The effect of substituted benzene-sulfonamides and clinically licensed drugs on the catalytic activity of cynt2, a carbonic anhydrase crucial for escherichia coli life cycle. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, pp. 1-14, ISSN:1661-6596 DOI

Bua S.; Lucarini L.; Micheli L.; Menicatti M.; Bartolucci G.; Selleri S.; Di Cesare Mannelli L.; Ghelardini C.; Masini E.; Carta F.; Gratteri P.; Nocentini A.; Supuran C.T. (2020). Bioisosteric Development of Multitarget Nonsteroidal Anti-Inflammatory Drug-Carbonic Anhydrases Inhibitor Hybrids for the Management of Rheumatoid Arthritis. JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, pp. 2325-2342, ISSN:0022-2623 DOI Accesso ONLINE all'editore

Alissa S.A.; Alghulikah H.A.; Alothman Z.A.; Osman S.M.; Del Prete S.; Capasso C.; Nocentini A.; Supuran C.T. (2020). Phosphonamidates are the first phosphorus-based zinc binding motif to show inhibition of β-class carbonic anhydrases from bacteria, fungi, and protozoa. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 59-64, ISSN:1475-6366 DOI

Bua S.; Lomelino C.; Murray A.B.; Osman S.M.; Alothman Z.A.; Bozdag M.; Abdel-Aziz H.A.; Eldehna W.M.; McKenna R.; Nocentini A.; Supuran C.T. (2020). "a Sweet Combination": Developing Saccharin and Acesulfame K Structures for Selectively Targeting the Tumor-Associated Carbonic Anhydrases IX and XII. JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, pp. 321-333, ISSN:0022-2623 DOI

Clima L.; Craciun B.F.; Angeli A.; Petreni A.; Bonardi A.; Nocentini A.; Carta F.; Gratteri P.; Pinteala M.; Supuran C.T. (2020). Synthesis, Computational Studies and Assessment of in Vitro Activity of Squalene Derivatives as Carbonic Anhydrase Inhibitors. CHEMMEDCHEM, vol. 15, pp. 2052-2057, ISSN:1860-7179 DOI

Bonardi A.; Nocentini A.; Cadoni R.; Del Prete S.; Dumy P.; Capasso C.; Gratteri P.; Supuran C.T.; Winum J.-Y. (2020). Benzoxaboroles: New Potent Inhibitors of the Carbonic Anhydrases of the Pathogenic Bacterium Vibrio cholerae. ACS MEDICINAL CHEMISTRY LETTERS, vol. 11, pp. 2277-2284, ISSN:1948-5875 DOI Accesso ONLINE all'editore

Bonardi A.; Nocentini A.; Bua S.; Combs J.; Lomelino C.; Andring J.; Lucarini L.; Sgambellone S.; Masini E.; McKenna R.; Gratteri P.; Supuran C.T. (2020). Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action. JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, pp. 7422-7444, ISSN:0022-2623 DOI

Alkhaldi A.A.M.; Al-Sanea M.M.; Nocentini A.; Eldehna W.M.; Elsayed Z.M.; Bonardi A.; Abo-Ashour M.F.; El-Damasy A.K.; Abdel-Maksoud M.S.; Al-Warhi T.; Gratteri P.; Abdel-Aziz H.A.; Supuran C.T.; El-Haggar R. (2020). 3-Methylthiazolo[3,2-a]benzimidazole-benzenesulfonamide conjugates as novel carbonic anhydrase inhibitors endowed with anticancer activity: Design, synthesis, biological and molecular modeling studies. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 207, pp. 0-0, ISSN:0223-5234 DOI

Picci G.; Bazzicalupi C.; Coles S.J.; Gratteri P.; Isaia F.; Lippolis V.; Montis R.; Murgia S.; Nocentini A.; Orton J.B.; Caltagirone C. (2020). Halogenated isophthalamides and dipicolineamides: The role of the halogen substituents in the anion binding properties. DALTON TRANSACTIONS, vol. 49, pp. 9231-9238, ISSN:1477-9226 DOI

El-Azab A.S.; Abdel-Aziz A.A.-M.; Ahmed H.E.A.; Bua S.; Nocentini A.; AlSaif N.A.; Obaidullah A.J.; Hefnawy M.M.; Supuran C.T. (2020). Exploring structure-activity relationship of S-substituted 2-mercaptoquinazolin-4(3H)-one including 4-ethylbenzenesulfonamides as human carbonic anhydrase inhibitors. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 598-609, ISSN:1475-6366 DOI

Del Prete S.; De Luca V.; De Luca V.; Nocentini A.; Scaloni A.; Mastrolorenzo M.D.; Mastrolorenzo M.D.; Supuran C.T.; Capasso C. (2020). Anion inhibition studies of the beta-carbonic anhydrase from Escherichia coli. MOLECULES, vol. 25, pp. 2564--, ISSN:1420-3049 DOI

Eldehna W.M.; Eldehna W.M.; Nocentini A.; Elsayed Z.M.; Al-Warhi T.; Aljaeed N.; Alotaibi O.J.; Al-Sanea M.M.; Abdel-Aziz H.A.; Supuran C.T. (2020). Benzofuran-Based Carboxylic Acids as Carbonic Anhydrase Inhibitors and Antiproliferative Agents against Breast Cancer. ACS MEDICINAL CHEMISTRY LETTERS, vol. 11, pp. 1022-1027, ISSN:1948-5875 DOI

La Regina G.; Puxeddu M.; Nalli M.; Vullo D.; Gratteri P.; Supuran C.T.; Nocentini A.; Silvestri R. (2020). Discovery of New 1,1′-Biphenyl-4-sulfonamides as Selective Subnanomolar Human Carbonic Anhydrase II Inhibitors. ACS MEDICINAL CHEMISTRY LETTERS, vol. 11, pp. 633-637, ISSN:1948-5875 DOI

Pustenko A.; Nocentini A.; Balasova A.; Krasavin M.; Zalubovskis R.; Supuran C.T. (2020). 7-Acylamino-3H-1,2-benzoxathiepine 2,2-dioxides as new isoform-selective carbonic anhydrase IX and XII inhibitors. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 650-656, ISSN:1475-6366 DOI Accesso ONLINE all'editore

Luchinat, Enrico; Barbieri, Letizia; Cremonini, Matteo; Nocentini, Alessio; Supuran, Claudiu T; Banci, Lucia (2020). Intracellular Binding/Unbinding Kinetics of Approved Drugs to Carbonic Anhydrase II Observed by in-Cell NMR. ACS CHEMICAL BIOLOGY, vol. 15, pp. 2792-2800, ISSN:1554-8929 DOI Accesso ONLINE all'editore

Ceni C.; Catarzi D.; Varano F.; Ben D.D.; Marucci G.; Buccioni M.; Volpini R.; Angeli A.; Nocentini A.; Gratteri P.; Supuran C.T.; Colotta V. (2020). Discovery of first-in-class multi-target adenosine A2A receptor antagonists-carbonic anhydrase IX and XII inhibitors. 8-Amino-6-aryl-2-phenyl-1,2,4-triazolo [4,3-a]pyrazin-3-one derivatives as new potential antitumor agents. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 201, pp. 0-16, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Luchinat E.; Barbieri L.; Cremonini M.; Nocentini A.; Supuran C.T.; Banci L. (2020). Drug Screening in Human Cells by NMR Spectroscopy Allows the Early Assessment of Drug Potency. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, vol. 59, pp. 6535-6539, ISSN:1433-7851 DOI Accesso ONLINE all'editore

Nguyen, Giang T H; Nocentini, Alessio; Angeli, Andrea; Gratteri, Paola; Supuran, Claudiu T; Donald, William A (2020). Perfluoroalkyl Substances of Significant Environmental Concern Can Strongly Inhibit Human Carbonic Anhydrase Isozymes. ANALYTICAL CHEMISTRY, vol. 92, pp. 4614-4622, ISSN:0003-2700 DOI

Pustenko A.; Nocentini A.; Balasova A.; Alafeefy A.; Krasavin M.; Zalubovskis R.; Supuran C.T. (2020). Aryl derivatives of 3H-1,2-benzoxathiepine 2,2-dioxide as carbonic anhydrase inhibitors. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 245-254, ISSN:1475-6366 DOI Accesso ONLINE all'editore

Uslu A.G.; Gur Maz T.; Nocentini A.; Banoglu E.; Supuran C.T.; Caliskan B. (2020). Benzimidazole derivatives as potent and isoform selective tumor-associated carbonic anhydrase IX/XII inhibitors. BIOORGANIC CHEMISTRY, vol. 95, pp. 103544-103544, ISSN:0045-2068 DOI

Scheila Daiane Schmidt, Alessia Costa, Barbara Rani, Eduarda Godfried Nachtigall, Maria Beatrice Passani, Fabrizio Carta, Alessio Nocentini, Jociane de Carvalho Myskiw, Cristiane Regina Guerino Furini, Claudiu T. Supuran, Ivan Izquierdo, Patrizio Blandina, Gustavo Provensi (2020). The role of carbonic anhydrases in extinction of contextual fear memory. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, pp. 1-9, ISSN:0027-8424 DOI

Nocentini A.; Alterio V.; Bua S.; Micheli L.; Esposito D.; Buonanno M.; Bartolucci G.; Osman S.M.; Alothman Z.A.; Cirilli R.; Pierini M.; Monti S.M.; Di Cesare Mannelli L.; Gratteri P.; Ghelardini C.; De Simone G.; Supuran C.T. (2020). Phenyl(thio)phosphon(amid)ate Benzenesulfonamides as Potent and Selective Inhibitors of Human Carbonic Anhydrases II and VII Counteract Allodynia in a Mouse Model of Oxaliplatin-Induced Neuropathy. JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, pp. 5185-5200, ISSN:0022-2623 DOI

Guglielmi P.; Rotondi G.; Secci D.; Angeli A.; Chimenti P.; Nocentini A.; Bonardi A.; Gratteri P.; Carradori S.; Supuran C.T. (2020). Novel insights on saccharin- and acesulfame-based carbonic anhydrase inhibitors: design, synthesis, modelling investigations and biological activity evaluation. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 1891-1905, ISSN:1475-6366 DOI

Berrino E.; Milazzo L.; Micheli L.; Vullo D.; Angeli A.; Bozdag M.; Nocentini A.; Menicatti M.; Bartolucci G.; Di Cesare Mannelli L.; Ghelardini C.; Supuran C.T.; Carta F. (2019). Synthesis and evaluation of carbonic anhydrase inhibitors with carbon monoxide releasing properties for the management of rheumatoid arthritis. JOURNAL OF MEDICINAL CHEMISTRY, vol. 62, pp. 7233-7249, ISSN:1520-4804 DOI

Pasha A.; Vignoli M.; Subbiani A.; Nocentini A.; Selleri S.; Gratteri P.; Dabraio A.; Casini T.; Filippi L.; Fotzi I.; Favre C.; Calvani M. (2019). β3-adrenoreceptor activity limits apigenin efficacy in ewing sarcoma cells: A dual approach to prevent cell survival. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 20, pp. 2149-2162, ISSN:1661-6596 DOI Accesso ONLINE all'editore

Nocentini, Alessio; Gratteri, Paola*; Supuran, Claudiu T. (2019). Phosphorus versus Sulfur: Discovery of Benzenephosphonamidates as Versatile Sulfonamide-Mimic Chemotypes Acting as Carbonic Anhydrase Inhibitors. CHEMISTRY-A EUROPEAN JOURNAL, vol. 25, pp. 1188-1192, ISSN:0947-6539 DOI Accesso ONLINE all'editore

Bonardi, Alessandro; Vermelho, Alane Beatriz; Da Silva Cardoso, Veronica; De Souza Pereira, Mirian Claudia; Da Silva Lara, Leonardo; Selleri, Silvia; Gratteri, Paola; Supuran, Claudiu T.; Nocentini, Alessio (2019). N-Nitrosulfonamides as Carbonic Anhydrase Inhibitors: A Promising Chemotype for Targeting Chagas Disease and Leishmaniasis. ACS MEDICINAL CHEMISTRY LETTERS, vol. 10, pp. 413-418, ISSN:1948-5875 DOI Accesso ONLINE all'editore

Eldehna, Wagdy M.*; Abo-Ashour, Mahmoud F.; Nocentini, Alessio; El-Haggar, Radwan S.; Bua, Silvia; Bonardi, Alessandro; Al-Rashood, Sara T.; Hassan, Ghada S.; Gratteri, Paola; Abdel-Aziz, Hatem A.; Supuran, Claudiu T. (2019). Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 162, pp. 147-160, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Vats L.; Kumar R.; Bua S.; Nocentini A.; Gratteri P.; Supuran C.T.; Sharma P.K. (2019). Continued exploration and tail approach synthesis of benzenesulfonamides containing triazole and dual triazole moieties as carbonic anhydrase I, II, IV and IX inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 183, pp. 1-10, ISSN:0223-5234 DOI

Angeli, Andrea; Tanini, Damiano; Nocentini, Alessio; Capperucci, Antonella; Ferraroni, Marta; Gratteri, Paola; Supuran, Claudiu T.* (2019). Selenols: a new class of carbonic anhydrase inhibitors. CHEMICAL COMMUNICATIONS, vol. 55, pp. 648-651, ISSN:1359-7345 DOI Accesso ONLINE all'editore

El-Azab, Adel S; Abdel-Aziz, Alaa A-M; Bua, Sivia; Nocentini, Alessio; El-Gendy, Manal A; Mohamed, Menshawy A; Shawer, Taghreed Z; AlSaif, Nawaf A; Supuran, Claudiu T (2019). Synthesis of benzensulfonamides linked to quinazoline scaffolds as novel carbonic anhydrase inhibitors. BIOORGANIC CHEMISTRY, vol. 87, pp. 78-90, ISSN:0045-2068 DOI

Krasavin, Mikhail; Shetnev, Anton; Baykov, Sergey; Kalinin, Stanislav; Nocentini, Alessio; Sharoyko, Vladimir; Poli, Giulio; Tuccinardi, Tiziano; Korsakov, Mikhail; Tennikova, Tatiana B; Supuran, Claudiu T (2019). Pyridazinone-substituted benzenesulfonamides display potent inhibition of membrane-bound human carbonic anhydrase IX and promising antiproliferative activity against cancer cell lines. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 168, pp. 301-314, ISSN:1768-3254 DOI

Bua, Silvia; Osman, Sameh M; Del Prete, Sonia; Capasso, Clemente; AlOthman, Zeid; Nocentini, Alessio; Supuran, Claudiu T (2019). Click-tailed benzenesulfonamides as potent bacterial carbonic anhydrase inhibitors for targeting Mycobacterium tuberculosis and Vibrio cholerae. BIOORGANIC CHEMISTRY, vol. 86, pp. 183-186, ISSN:0045-2068 DOI

Rogato, Alessandra; Del Prete, Sonia; Nocentini, Alessio; Carginale, Vincenzo; Supuran, Claudiu T; Capasso, Clemente (2019). Phaeodactylum tricornutum as a model organism for testing the membrane penetrability of sulphonamide carbonic anhydrase inhibitors. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 34, pp. 510-518, ISSN:1475-6374 DOI

Abo-Ashour, Mahmoud F; Eldehna, Wagdy M; Nocentini, Alessio; Ibrahim, Hany S; Bua, Silvia; Abdel-Aziz, Hatem A; Abou-Seri, Sahar M; Supuran, Claudiu T (2019). Novel synthesized SLC-0111 thiazole and thiadiazole analogues: Determination of their carbonic anhydrase inhibitory activity and molecular modeling studies. BIOORGANIC CHEMISTRY, vol. 87, pp. 794-802, ISSN:0045-2068 DOI

Krasavin, Mikhail; Shetnev, Anton; Sharonova, Tatyana; Baykov, Sergey; Kalinin, Stanislav; Nocentini, Alessio; Sharoyko, Vladimir; Poli, Giulio; Tuccinardi, Tiziano; Presnukhina, Sofia; Tennikova, Tatiana B; Supuran, Claudiu T (2019). Continued exploration of 1,2,4-oxadiazole periphery for carbonic anhydrase-targeting primary arene sulfonamides: Discovery of subnanomolar inhibitors of membrane-bound hCA IX isoform that selectively kill cancer cells in hypoxic environment. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 164, pp. 92-105, ISSN:1768-3254 DOI

Aimene, Yassine; Eychenne, Romain; Mallet-Ladeira, Sonia; Saffon, Nathalie; Winum, Jean-Yves; Nocentini, Alessio; Supuran, Claudiu T; Benoist, Eric; Seridi, Achour (2019). Novel Re(I) tricarbonyl coordination compounds based on 2-pyridyl-1,2,3-triazole derivatives bearing a 4-amino-substituted benzenesulfonamide arm: synthesis, crystal structure, computational studies and inhibitory activity against carbonic anhydrase I, II, and IX isoforms†. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 34, pp. 773-782, ISSN:1475-6374 DOI

Abdel-Aziz, Alaa A-M; El-Azab, Adel S; Bua, Silvia; Nocentini, Alessio; Abu El-Enin, Mohamed A; Alanazi, Mohammed M; AlSaif, Nawaf A; Hefnawy, Mohamed M; Supuran, Claudiu T (2019). Design, synthesis, and carbonic anhydrase inhibition activity of benzenesulfonamide-linked novel pyrazoline derivatives. BIOORGANIC CHEMISTRY, vol. 87, pp. 425-431, ISSN:0045-2068 DOI

Bua, Silvia; Osman, Sameh M; AlOthman, Zeid; Supuran, Claudiu T; Nocentini, Alessio (2019). Benzenesulfonamides incorporating nitrogenous bases show effective inhibition of β-carbonic anhydrases from the pathogenic fungi Cryptococcus neoformans, Candida glabrata and Malassezia globosa. BIOORGANIC CHEMISTRY, vol. 86, pp. 39-43, ISSN:0045-2068 DOI

Akocak, Suleyman; Lolak, Nabih; Bua, Silvia; Nocentini, Alessio; Karakoc, Gulcin; Supuran, Claudiu T (2019). α-Carbonic anhydrases are strongly activated by spinaceamine derivatives. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 27, pp. 800-804, ISSN:1464-3391 DOI

Allam H.A.; Fahim S.H.; F.Abo-Ashour M.; Nocentini A.; Elbakry M.E.; Abdelrahman M.A.; Eldehna W.M.; Ibrahim H.S.; Supuran C.T. (2019). Application of hydrazino and hydrazido linkers to connect benzenesulfonamides with hydrophilic/phobic tails for targeting the middle region of human carbonic anhydrases active site: Selective inhibitors of hCA IX. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 179, pp. 547-556, ISSN:1768-3254 DOI Accesso ONLINE all'editore

Abdelrahman M.A.; Eldehna W.M.; Nocentini A.; Bua S.; Al-Rashood S.T.; Hassan G.S.; Bonardi A.; Almehizia A.A.; Alkahtani H.M.; Alharbi A.; Gratteri P.; Supuran C.T. (2019). Novel diamide-based benzenesulfonamides as selective carbonic anhydrase ix inhibitors endowed with antitumor activity: Synthesis, biological evaluation and in silico insights. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 20, pp. 2484-2499, ISSN:1661-6596 DOI Accesso ONLINE all'editore

Akocak S.; Lolak N.; Bua S.; Nocentini A.; Supuran C.T. (2019). Activation of human α-carbonic anhydrase isoforms I, II, IV and VII with bis-histamine schiff bases and bis-spinaceamine substituted derivatives. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 34, pp. 1193-1198, ISSN:1475-6366 DOI

Kalinin, Stanislav; Nocentini, Alessio; Kovalenko, Alexander; Sharoyko, Vladimir; Bonardi, Alessandro; Angeli, Andrea; Gratteri, Paola; Tennikova, Tatiana B.; Supuran, Claudiu T.; Krasavin, Mikhail (2019). From random to rational: A discovery approach to selective subnanomolar inhibitors of human carbonic anhydrase IV based on the Castagnoli-Cushman multicomponent reaction. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 182, pp. 111642-111660, ISSN:1768-3254 DOI

El-Azab A.S.; Abdel-Aziz A.A.-M.; Bua S.; Nocentini A.; Alanazi M.M.; AlSaif N.A.; Al-Suwaidan I.A.; Hefnawy M.M.; Supuran C.T. (2019). Synthesis and comparative carbonic anhydrase inhibition of new Schiff's bases incorporating benzenesulfonamide, methanesulfonamide, and methylsulfonylbenzene scaffolds. BIOORGANIC CHEMISTRY, vol. 92, pp. 103225-103225, ISSN:0045-2068 DOI

Eldehna W.M.; Abdelrahman M.A.; Nocentini A.; Bua S.; Al-Rashood S.T.; Hassan G.S.; Bonardi A.; Almehizia A.A.; Alkahtani H.M.; Alharbi A.; Gratteri P.; Supuran C.T. (2019). Synthesis, biological evaluation and in silico studies with 4-benzylidene-2-phenyl-5(4H)-imidazolone-based benzenesulfonamides as novel selective carbonic anhydrase IX inhibitors endowed with anticancer activity. BIOORGANIC CHEMISTRY, vol. 90, pp. 103102-103111, ISSN:0045-2068 DOI Accesso ONLINE all'editore

Nocentini A.; Supuran C.T. (2019). Advances in the structural annotation of human carbonic anhydrases and impact on future drug discovery. EXPERT OPINION ON DRUG DISCOVERY, vol. 14, pp. 1175-1197, ISSN:1746-0441 DOI

Nocentini A.; Osman S.M.; Del Prete S.; Capasso C.; ALOthman Z.A.; Supuran C.T. (2019). Extending the γ-class carbonic anhydrases inhibition profiles with phenolic compounds. BIOORGANIC CHEMISTRY, vol. 93, pp. 103336-103336, ISSN:0045-2068 DOI

Nocentini A.; Osman S.M.; Almeida I.A.; Cardoso V.; Alasmary F.A.S.; AlOthman Z.; Vermelho A.B.; Gratteri P.; Supuran C.T. (2019). Appraisal of anti-protozoan activity of nitroaromatic benzenesulfonamides inhibiting carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 34 (1), pp. 1164-1171, ISSN:1475-6366, TAYLOR & FRANCIS LTD: DOI Accesso ONLINE all'editore

Milite C.; Amendola G.; Nocentini A.; Bua S.; Cipriano A.; Barresi E.; Feoli A.; Novellino E.; Da Settimo F.; Supuran C.T.; Castellano S.; Cosconati S.; Taliani S. (2019). Novel 2-substituted-benzimidazole-6-sulfonamides as carbonic anhydrase inhibitors: synthesis, biological evaluation against isoforms I, II, IX and XII and molecular docking studies. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 34, pp. 1697-1710, ISSN:1475-6366 DOI

Kalinin S.; Valtari A.; Ruponen M.; Toropainen E.; Kovalenko A.; Nocentini A.; Gureev M.; Dar'in D.; Urtti A.; Supuran C.T.; Krasavin M. (2019). Highly hydrophilic 1,3-oxazol-5-yl benzenesulfonamide inhibitors of carbonic anhydrase II for reduction of glaucoma-related intraocular pressure. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 27, pp. 115086--, ISSN:0968-0896 DOI

El-Azab A.S.; Abdel-Aziz A.A.-M.; Bua S.; Nocentini A.; AlSaif N.A.; Almehizia A.A.; Alanazi M.M.; Hefnawy M.M.; Supuran C.T. (2019). New anthranilic acid-incorporating N-benzenesulfonamidophthalimides as potent inhibitors of carbonic anhydrases I, II, IX, and XII: Synthesis, in vitro testing, and in silico assessment. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 181, pp. 111573--, ISSN:0223-5234 DOI

Nocentini A.; Supuran C.T. (2019). Adrenergic agonists and antagonists as antiglaucoma agents: a literature and patent review (2013–2019). EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 29, pp. 805-815, ISSN:1354-3776 DOI

Angeli A.; Ferraroni M.; Nocentini A.; Selleri S.; Gratteri P.; Supuran C.T.; Carta F. (2019). Polypharmacology of epacadostat: A potent and selective inhibitor of the tumor associated carbonic anhydrases IX and XII. CHEMICAL COMMUNICATIONS, vol. 55, pp. 5720-5723, ISSN:1359-7345 DOI Accesso ONLINE all'editore

Kartsev V.; Geronikaki A.; Bua S.; Nocentini A.; Petrou A.; Lichitsky B.; Frasinyuk M.; Leitans J.; Kazaks A.; Tars K.; Supuran C.T. (2019). Extending the inhibition profiles of coumarin-based compounds against human carbonic anhydrases: Synthesis, biological, and in silico evaluation. MOLECULES, vol. 24, pp. 3580--, ISSN:1420-3049 DOI

Kurt B.Z.; Dag A.; Dogan B.; Durdagi S.; Angeli A.; Nocentini A.; Supuran C.T.; Sonmez F. (2019). Synthesis, biological activity and multiscale molecular modeling studies of bis-coumarins as selective carbonic anhydrase IX and XII inhibitors with effective cytotoxicity against hepatocellular carcinoma. BIOORGANIC CHEMISTRY, vol. 87, pp. 838-850, ISSN:0045-2068 DOI Accesso ONLINE all'editore

Bibi D.; Shusterman B.; Nocentini A.; Supuran C.T.; Bialer M. (2019). Stereoselective pharmacokinetic and pharmacodynamic analysis of a CNS-active sulphamoylphenyl carbamate derivative. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 34, pp. 1078-1082, ISSN:1475-6366 DOI

Nocentini A.; Tanc M. (2019). CO2-capture by engineered mammalian carbonic anhydrases. In: Alessio Nocentini, Claudiu T. Supuran. Carbonic Anhydrases: Biochemistry and Pharmacology of an Evergreen Pharmaceutical Target, pp. 515-530 Elsevier, ISBN:9780128164761. DOI

Nocentini A.; Supuran C.T. (2019). Carbonic anhydrase inhibitors for the treatment of neuropathic pain and arthritis. In: Alessio Nocentini, Claudiu T. Supuran. Carbonic Anhydrases: Biochemistry and Pharmacology of an Evergreen Pharmaceutical Target, pp. 367-386 Elsevier, ISBN:9780128164761. DOI

Nocentini A.; Donald W.A.; Supuran C.T. (2019). Human carbonic anhydrases: Tissue distribution, physiological role, and druggability. In: Alessio Nocentini, Claudiu T. Supuran. Carbonic Anhydrases: Biochemistry and Pharmacology of an Evergreen Pharmaceutical Target, pp. 151-185 Elsevier, ISBN:9780128164761. DOI

Bua S.; Nocentini A.; Supuran C.T. (2019). Carbonic anhydrase inhibitors as diuretics. In: Alessio Nocentini, Claudiu T. Supuran. Carbonic Anhydrases: Biochemistry and Pharmacology of an Evergreen Pharmaceutical Target, pp. 287-309 Elsevier, ISBN:9780128164761. DOI

Nocentini A.; Supuran C.T. (2019). Preface. In: Alessio Nocentini, Claudiu T. Supuran. Carbonic Anhydrases: Biochemistry and Pharmacology of an Evergreen Pharmaceutical Target, pp. xvii-xix Elsevier, ISBN:9780128164761. DOI

Nocentini A.; Supuran C.T. (2019). Carbonic anhydrases: An overview. In: Alessio Nocentini, Claudiu T.Supuran. Carbonic Anhydrases: Biochemistry and Pharmacology of an Evergreen Pharmaceutical Target, pp. 3-16 Elsevier, ISBN:9780128164761. DOI

Nocentini, Alessio; Lucidi, Alessia; Perut, Francesca; Massa, Annamaria; Tomaselli, Daniela; Gratteri, Paola; Baldini, Nicola; Rotili, Dante; Mai, Antonello; Supuran, Claudiu T.* (2019). α,γ-Diketocarboxylic Acids and Their Esters Act as Carbonic Anhydrase IX and XII Selective Inhibitors. ACS MEDICINAL CHEMISTRY LETTERS, vol. 10, pp. 661-665, ISSN:1948-5875 DOI Accesso ONLINE all'editore

Abo-Ashour M.F.; Eldehna W.M.; Nocentini A.; Bonardi A.; Bua S.; Ibrahim H.S.; Elaasser M.M.; Krystof V.; Jorda R.; Gratteri P.; Abou-Seri S.M.; Supuran C.T. (2019). 3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and in silico insights. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 184, pp. 1-11, ISSN:0223-5234 DOI

Gustavo Provensi, Fabrizio Carta, Alessio Nocentini, Claudiu T. Supuran, Fiorella Casamenti, Maria Beatrice Passani, Silvia Fossati (2019). A New Kid on the Block? Carbonic Anhydrases as Possible New Targets in Alzheimer's Disease. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 20, pp. 4724-4741, ISSN:1422-0067 DOI

Moi D.; Nocentini A.; Deplano A.; Balboni G.; Supuran C.T.; Onnis V. (2019). Structure-activity relationship with pyrazoline-based aromatic sulfamates as carbonic anhydrase isoforms I, II, IX and XII inhibitors: Synthesis and biological evaluation. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 182, pp. 111638-111649, ISSN:1768-3254 DOI

Alessandro Bonardi, Paola Gratteri, Alessio Nocentini (2019). Chpater 19 Carbonic Anhydrases from Pathogens: Fungal Carbonic Anhydrases And Their Inhibitors as Potential Antifungal Agents.. In: C.T. Supuran, A. Nocentini. Carbonic Anhydrases, pp. 419-448 Elsevier, ISBN:978-0-12-816476-1. DOI Accesso ONLINE all'editore

Supuran C.T.; Nocentini A. (2019). Carbonic anhydrases: Biochemistry and pharmacology of an evergreen pharmaceutical target. Elsevier, ISBN:9780128164761 DOI

Larcher A.; Nocentini A.; Supuran C.T.; Winum J.-Y.; Van Der Lee A.; Vasseur J.-J.; Laurencin D.; Smietana M. (2019). Bis-benzoxaboroles: design, synthesis, and biological evaluation as carbonic anhydrase inhibitors. ACS MEDICINAL CHEMISTRY LETTERS, vol. 10, pp. 1205-1210, ISSN:1948-5875 DOI

Abdel-Aziz, Alaa A.-M.; El-Azab, Adel S.; Ghiaty, Adel H.; Gratteri, Paola; Supuran, Claudiu T.; Nocentini, Alessio (2019). 4-Substituted benzenesulfonamides featuring cyclic imides moieties exhibit potent and isoform-selective carbonic anhydrase II/IX inhibition. BIOORGANIC CHEMISTRY, vol. 83, pp. 198-204, ISSN:0045-2068, Academic Press Inc.: 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA DOI Accesso ONLINE all'editore

Nocentini, Alessio; Cadoni, Roberta; Dumy, Pascal; Supuran, Claudiu T; Winum, Jean-Yves (2018). Carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani chagasi are inhibited by benzoxaboroles. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 33, pp. 286-289, ISSN:1475-6366 DOI

Nocentini, Alessio; Bonardi, Alessandro; Gratteri, Paola; Cerra, Bruno; Gioiello, Antimo*; Supuran, Claudiu T. (2018). Steroids interfere with human carbonic anhydrase activity by using alternative binding mechanisms. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 33, pp. 1453-1459, ISSN:1475-6366 DOI Accesso ONLINE all'editore

Ibrahim, Hany S.*; Allam, Heba Abdelrasheed; Mahmoud, Walaa R.; Bonardi, Alessandro; Nocentini, Alessio; Gratteri, Paola; Ibrahim, Eslam S.; Abdel-Aziz, Hatem A.; Supuran, Claudiu T. (2018). Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective inhibitors for the tumor-associated hCA IX isoform. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 152, pp. 1-9, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Niccolò Chiaramonte, Silvia Bua, Marta Ferraroni, Alessio Nocentini, Alessandro Bonardi, Gian Luca Bartolucci, Maria Concetta Durante, Laura Lucarini, Donata Chiapponi, Silvia Dei, Dina Manetti, Elisabetta Teodori, Paola Gratteri, Emanuela Masini, Claudiu T. Supuran, Maria Novella Romanelli (2018). 2-Benzylpiperazine: a new scaffold for potent human Carbonic Anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 151, pp. 363-375, ISSN:1768-3254 DOI

Awadallah, Fadi M.; Bua, Silvia; Mahmoud, Walaa R.; Nada, Hossam H.; Nocentini, Alessio; Supuran, Claudiu T.* (2018). Inhibition studies on a panel of human carbonic anhydrases with N1-substituted secondary sulfonamides incorporating thiazolinone or imidazolone-indole tails. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 33, pp. 629-638, ISSN:1475-6366 DOI

Mahmood, Shams-ul; Saeed, Aamer*; Bua, Sivia; Nocentini, Alessio; Gratteri, Paola; Supuran, Claudiu T. (2018). Synthesis, biological evaluation and computational studies of novel iminothiazolidinone benzenesulfonamides as potent carbonic anhydrase II and IX inhibitors. BIOORGANIC CHEMISTRY, vol. 77, pp. 381-386, ISSN:0045-2068 DOI Accesso ONLINE all'editore

Nocentini, Alessio; Supuran, Claudiu T; Winum, Jean-Yves (2018). Benzoxaborole compounds for therapeutic uses: a patent review (2010- 2018). EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 28, pp. 493-504, ISSN:1354-3776 DOI

Eldehna, Wagdy M; Nocentini, Alessio; Al-Rashood, Sara T; Hassan, Ghada S; Alkahtani, Hamad M; Almehizia, Abdulrahman A; Reda, Ahmed M; Abdel-Aziz, Hatem A; Supuran, Claudiu T (2018). Tumor-associated carbonic anhydrase isoform IX and XII inhibitory properties of certain isatin-bearing sulfonamides endowed with in vitro antitumor activity towards colon cancer. BIOORGANIC CHEMISTRY, vol. 81, pp. 425-432, ISSN:0045-2068 DOI

Nocentini, Alessio; Moi, Davide; Balboni, Gianfranco; Salvadori, Severo; Onnis, Valentina; Supuran, Claudiu T (2018). Synthesis and biological evaluation of novel pyrazoline-based aromatic sulfamates with potent carbonic anhydrase isoforms II, IV and IX inhibitory efficacy. BIOORGANIC CHEMISTRY, vol. 77, pp. 633-639, ISSN:0045-2068 DOI

Nocentini, Alessio; Supuran, Claudiu T (2018). Carbonic anhydrase inhibitors as antitumor/antimetastatic agents: a patent review (2008-2018). EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 28, pp. 729-740, ISSN:1354-3776 DOI

El-Gazzar, Marwa G; Nafie, Nessma H; Nocentini, Alessio; Ghorab, Mostafa M; Heiba, Helmi I; Supuran, Claudiu T (2018). Carbonic anhydrase inhibition with a series of novel benzenesulfonamide-triazole conjugates. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 33, pp. 1565-1574, ISSN:1475-6374 DOI

Nakai, Misaki; Pan, Jihne; Lin, Kuo-Shyan; Thompson, John R; Nocentini, Alessio; Supuran, Claudiu T; Nakabayashi, Yasuo; Storr, Tim (2018). Evaluation of 99mTc-sulfonamide and sulfocoumarin derivatives for imaging carbonic anhydrase IX expression. JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 185, pp. 63-70, ISSN:1873-3344 DOI

Nocentini, Alessio; Bua, Silvia; Del Prete, Sonia; Heravi, Yeganeh Entezari; Saboury, Ali A; Karioti, Anastasia; Bilia, Anna Rita; Capasso, Clemente; Gratteri, Paola; Supuran, Claudiu T (2018). Natural Polyphenols Selectively Inhibit β-Carbonic Anhydrase from the Dandruff-Producing Fungus Malassezia globosa: Activity and Modeling Studies. CHEMMEDCHEM, vol. 13, pp. 816-823, ISSN:1860-7179 DOI

Mahmoud F. Abo-Ashour; Wagdy M. Eldehna; Alessio Nocentini; Hany S. Ibrahim; Silvia Bua; Sahar M. Abou-Seri; Claudiu T. Supuran (2018). Novel hydrazido benzenesulfonamides-isatin conjugates: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 157, pp. 28-36, ISSN:0223-5234 DOI

Nocentini, Alessio; Moi, Davide; Balboni, Gianfranco; Onnis, Valentina; Supuran, Claudiu T (2018). Discovery of thiazolin-4-one-based aromatic sulfamates as a new class of carbonic anhydrase isoforms I, II, IV, and IX inhibitors. BIOORGANIC CHEMISTRY, vol. 77, pp. 293-299, ISSN:0045-2068 DOI

Diuzheva, Alina; Carradori, Simone; Andruch, Vasil; Locatelli, Marcello; Luca, Elisa De; Tiecco, Matteo; Germani, Raimondo; Menghini, Luigi; Nocentini, Alessio; Gratteri, Paola; Campestre, Cristina (2018). Use of Innovative (Micro)Extraction Techniques to Characterise Harpagophytum procumbens Root and its Commercial Food Supplements. PHYTOCHEMICAL ANALYSIS, vol. 29, pp. 233-241, ISSN:0958-0344 DOI Accesso ONLINE all'editore

Nocentini, Alessio; Carta, Fabrizio; Tanc, Muhammet; Selleri, Silvia; Supuran, Claudiu T.; Bazzicalupi, Carla*; Gratteri, Paola (2018). Deciphering the Mechanism of Human Carbonic Anhydrases Inhibition with Sulfocoumarins: Computational and Experimental Studies. CHEMISTRY-A EUROPEAN JOURNAL, vol. 24, pp. 7840-7844, ISSN:0947-6539 DOI Accesso ONLINE all'editore

Nocentini A, Trallori E, Singh S, Lomelino CL, Bartolucci G, Di Cesare Mannelli L, Ghelardini C, McKenna R, Gratteri P, Supuran CT (2018). 4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII showing hypoxia-enhanced anti-proliferative profiles.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 61, pp. 10860-10874, ISSN:0022-2623 DOI Accesso ONLINE all'editore

Abdel-Aziz, Alaa A-M; El-Azab, Adel S; Abu El-Enin, Mohamed A; Almehizia, Abdulrahman A; Supuran, Claudiu T; Nocentini, Alessio (2018). Synthesis of novel isoindoline-1,3-dione-based oximes and benzenesulfonamide hydrazones as selective inhibitors of the tumor-associated carbonic anhydrase IX. BIOORGANIC CHEMISTRY, vol. 80, pp. 706-713, ISSN:0045-2068 DOI

Nocentini, Alessio; Ceruso, Mariangela; Bua, Silvia; Lomelino, Carrie L.; Andring, Jacob T.; McKenna, Robert; Lanzi, Cecilia; Sgambellone, Silvia; Pecori, Riccardo; Matucci, Rosanna; Filippi, Luca; Gratteri, Paola; Carta, Fabrizio; Masini, Emanuela; Selleri, Silvia*; Supuran, Claudiu T. (2018). Discovery of β-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy. JOURNAL OF MEDICINAL CHEMISTRY, vol. 61, pp. 5380-5394, ISSN:0022-2623 DOI Accesso ONLINE all'editore

Alessio Nocentini (2018). MODELING AND STRUCTURE-BASED APPROACHES IN THE DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF LIGANDS TARGETING THE METALLOENZYMES CARBONIC ANHYDRASES. (Tutor: Paola Gratteri e Claudiu T. Supuran)

Nocentini, Alessio; Vullo, Daniela; Del Prete, Sonia; Osman, Sameh M.; Alasmary, Fatmah A. S.; Alothman, Zeid; Capasso, Clemente; Carta, Fabrizio; Gratteri, Paola; Supuran, Claudiu T. (2017). Inhibition of the Î²-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa with monothiocarbamates. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 32, pp. 1064-1070, ISSN:1475-6366 DOI Accesso ONLINE all'editore

Zhang, Zhengxing; Lau, Joseph; Zhang, Chengcheng; Colpo, Nadine; Nocentini, Alessio; Supuran, Claudiu T; Bénard, François; Lin, Kuo-Shyan (2017). Design, synthesis and evaluation of 18F-labeled cationic carbonic anhydrase IX inhibitors for PET imaging. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 32, pp. 722-730, ISSN:1475-6374 DOI

Bibi, David; Mawasi, Hafiz; Nocentini, Alessio; Supuran, Claudiu T; Wlodarczyk, Bogdan; Finnell, Richard H; Bialer, Meir (2017). Design and Comparative Evaluation of the Anticonvulsant Profile, Carbonic-Anhydrate Inhibition and Teratogenicity of Novel Carbamate Derivatives of Branched Aliphatic Carboxylic Acids with 4-Aminobenzensulfonamide. NEUROCHEMICAL RESEARCH, vol. 42, pp. 1972-1982, ISSN:0364-3190 DOI

Eldehna, Wagdy M.; Abo-Ashour, Mahmoud F.; Nocentini, Alessio; Gratteri, Paola; Eissa, Ibrahim H.; Fares, Mohamed; Ismael, Omnia E.; Ghabbour, Hazem A.; Elaasser, Mahmoud M.; Abdel-Aziz, Hatem A.; Supuran, Claudiu T. (2017). Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 139, pp. 250-262, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Nocentini, Alessio; Bua, Silvia; Lomelino, Carrie L.; Mckenna, Robert; Menicatti, Marta; Bartolucci, Gianluca; Tenci, Barbara; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Gratteri, Paola; Supuran, Claudiu T. (2017). Discovery of New Sulfonamide Carbonic Anhydrase IX Inhibitors Incorporating Nitrogenous Bases. ACS MEDICINAL CHEMISTRY LETTERS, vol. 8, pp. 1314-1319, ISSN:1948-5875 DOI Accesso ONLINE all'editore

Angeli, Andrea; Abdel-Aziz, Alaa A. -. M.; Nocentini, Alessio; El-Azab, Adel S.; Gratteri, Paola; Supuran, Claudiu T. (2017). Synthesis and carbonic anhydrase inhibition of polycyclic imides incorporating N-benzenesulfonamide moieties. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 25, pp. 5373-5379, ISSN:0968-0896 DOI Accesso ONLINE all'editore

Altug, Cevher; Güneş, Hanife; Nocentini, Alessio; Monti, Simona Maria; Buonanno, Martina; Supuran, Claudiu T. (2017). Synthesis of isoxazole-containing sulfonamides with potent carbonic anhydrase II and VII inhibitory properties. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 25, pp. 1456-1464, ISSN:0968-0896 DOI Accesso ONLINE all'editore

Fragai, Marco; Comito, Giuseppina; Di Cesare Mannelli, Lorenzo; Gualdani, Roberta; Calderone, Vito; Louka, Alexandra; Richichi, Barbara; Francesconi, Oscar; Angeli, Andrea; Nocentini, Alessio; Gratteri, Paola; Chiarugi, Paola; Ghelardini, Carla; Tadini-Buoninsegni, Francesco; Supuran, Claudiu T; Nativi, Cristina (2017). Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX). JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, pp. 9003-9011, ISSN:1520-4804 DOI

Vullo, Daniela; Del Prete, Sonia; Nocentini, Alessio; Osman, Sameh M.; Alothman, Zeid; Capasso, Clemente; Bozdag, Murat; Carta, Fabrizio; Gratteri, Paola; Supuran, Claudiu T. (2017). Dithiocarbamates effectively inhibit the β-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 25, pp. 1260-1265, ISSN:0968-0896 DOI Accesso ONLINE all'editore

Entezari Heravi, Yeganeh; Bua, Silvia; Nocentini, Alessio; Del Prete, Sonia; Saboury, Ali Akbar; Sereshti, Hassan; Capasso, Clemente; Gratteri, Paola; Supuran, Claudiu T (2017). Inhibition of Malassezia globosa carbonic anhydrase with phenols. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 25, pp. 2577-2582, ISSN:0968-0896 DOI Accesso ONLINE all'editore

Fares, Mohamed; Eladwy, Radwa A.; Nocentini, Alessio; El Hadi, Soha R. Abd; Ghabbour, Hazem A.; Abdel-Megeed, Ashraf; Eldehna, Wagdy M.; Abdel-Aziz, Hatem A.; Supuran, Claudiu T. (2017). Synthesis of bulky-tailed sulfonamides incorporating pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-1(5H)-yl) moieties and evaluation of their carbonic anhydrases I, II, IV and IX inhibitory effects. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 25, pp. 2210-2217, ISSN:0968-0896 DOI Accesso ONLINE all'editore

Akocak S.; Lolak N.; Nocentini A.; Karakoc G.; Tufan A.; Supuran C.T. (2017). Synthesis and biological evaluation of novel aromatic and heterocyclic bis-sulfonamide Schiff bases as carbonic anhydrase I, II, VII and IX inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 25, pp. 3093-3097, ISSN:0968-0896 DOI

Eldehna, Wagdy M; Al-Ansary, Ghada H.; Bua, Silvia; Nocentini, Alessio; Gratteri, Paola; Altoukhy, Ayman; Ghabbour, Hazem; Ahmed, Hanaa Y.; Supuran, Claudiu T. (2017). Novel indolin-2-one-based sulfonamides as carbonic anhydrase inhibitors: Synthesis, in vitro biological evaluation against carbonic anhydrases isoforms I, II, IV and VII and molecular docking studies. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 127, pp. 521-530, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Nocentini, Alessio; Cadoni, Roberta; Del Prete, Sonia; Capasso, Clemente; Dumy, Pascal; Gratteri, Paola; Supuran, Claudiu T.; Winum, Jean-Yves (2017). Benzoxaboroles as Efficient Inhibitors of the Î²-Carbonic Anhydrases from Pathogenic Fungi: Activity and Modeling Study. ACS MEDICINAL CHEMISTRY LETTERS, vol. 8, pp. 1194-1198, ISSN:1948-5875 DOI Accesso ONLINE all'editore

Ferraroni, Marta; Bazzicalupi, Carla; Papi, Francesco; Fiorillo, Gaetano; Guamán-Ortiz, Luis Miguel; Nocentini, Alessio; Scovassi, Anna Ivana; Lombardi, Paolo; Gratteri, Paola (2016). Solution and Solid-State Analysis of Binding of 13-Substituted Berberine Analogues to Human Telomeric G-quadruplexes. CHEMISTRY - AN ASIAN JOURNAL, vol. 11, pp. 1107-1115, ISSN:1861-4728 DOI Accesso ONLINE all'editore

Nocentini, Alessio; Ceruso, Mariangela; Carta, Fabrizio; Supuran, Claudiu T. (2016). 7-Aryl-triazolyl-substituted sulfocoumarins are potent, selective inhibitors of the tumor-associated carbonic anhydrase IX and XII. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 31, pp. 1226-1233, ISSN:1475-6366 DOI

Angeli, A; Peat, T.S.; Bartolucci, G.; Nocentini, A.; Supuran, C.T.; Carta, F. (2016). Intramolecular oxidative deselenization of acylselenoureas: a facile synthesis of benzoxazole amides and carbonic anhydrase inhibitors. ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 14, pp. 11353-11356, ISSN:1477-0520 DOI Accesso ONLINE all'editore

Nocentini, Alessio; Vullo, Daniela; Bartolucci, Gianluca; Supuran, Claudiu T (2016). N-Nitrosulfonamides: A new chemotype for carbonic anhydrase inhibition. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 24, pp. 3612-3617, ISSN:0968-0896 DOI Accesso ONLINE all'editore

Nocentini, Alessio; Ferraroni, Marta; Carta, Fabrizio; Ceruso, Mariangela; Gratteri, Paola; Lanzi, Cecilia; Masini, Emanuela; Supuran, Claudiu T (2016). Benzenesulfonamides Incorporating Flexible Triazole Moieties Are Highly Effective Carbonic Anhydrase Inhibitors: Synthesis and Kinetic, Crystallographic, Computational, and Intraocular Pressure Lowering Investigations. JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, pp. 10692-10704, ISSN:0022-2623 DOI Accesso ONLINE all'editore

Nocentini, Alessio; Carta, Fabrizio; Ceruso, Mariangela; Bartolucci, Gianluca; Supuran, Claudiu T. (2015). Click-tailed coumarins with potent and selective inhibitory action against the tumor-associated carbonic anhydrases IX and XII. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 23, pp. 6955-6966, ISSN:0968-0896 DOI Accesso ONLINE all'editore

Alessio NOCENTINI

Curriculum

EDUCATION

2014–2017 PhD cum laude in Area del Farmaco e Trattamenti Innovativi: Curriculum Scienze Farmaceutiche (Medicinal Chemistry), NEUROFARBA Department, University of Florence - PhD Supervisor: Prof. Paola Gratteri

2008–2014 MSc, 110/110 cum laude in Pharmaceutical Chemistry and Technology, Pharmacy, University of Florence

CURRENT AND PREVIOUS POSITION

2023–present RTD-b (Assistant Professor, SSD CHIM/08), NEUROFARBA Department, University of Florence, Italy

2020–2023 RTD-a (Assistant Professor, SSD CHIM/08), NEUROFARBA Department, University of Florence, Italy

2017–2020 Postdoctoral research fellowships, Supervisor: Prof. Claudiu T. Supuran, Prof. Paola Gratteri, NEUROFARBA Department, University of Florence

TEACHING ACTIVITIES

2020–present Professor of Medicinal Chemistry (course in English), Advanced molecular sciences, Univ. of Florence

2020–present Professor of Analisi dei Medicinali II, Pharmacy, Univ. of Florence

2020–present Professor of Molecular Modeling in Medicinal Chemistry, Pharmacy and Medicinal Chemistry and Technology.

ORGANISATION OF SCIENTIFIC MEETINGS

2017 Organizing committee, “3rd satellite meeting on Carbonic anhydrase”, Montecatini Terme, Italy

2022 Local organizing committee, “The 4th ISFMS: Biochemistry, Molecular Biology and Druggability of Proteins”, Firenze, Italy.

2023 Chairperson, “12th International conference on Carbonic Anhydrases”, Naples, Italy.

SUPERVISION OF GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS

2023-present Supervisor of a postdoctoral fellow

2015–present Supervisor/co-supervisor of >30 MSc students, Scuola di Scienze della Salute Umana and co-supervisor of 2 PhD students, NEUROFARBA Department, Univ. of Florence

LECTURES AT INTERNATIONAL CONFERENCES

INVITED SPEAKER

- Italian/Spanish-Portuguese Joint Meeting in Medicinal Chemistry 2018, Palermo.

- Cost Action CM1407, Meeting dedicated to Early Career Investigators 2019, Brussels, Belgium.

- 3rd HA-CTion meeting, 2021, Sesto Fiorentino, Italia.

- 2nd Drug Discovery Conference, 2022, Riga, Latvia.

- G4ME Perugia, 2024, Perugia, Italia.

Other lectures

- 3rd Satellite Meeting on Carbonic Anhydrase, 2017, Montecatini Terme, Italia.

- 11th International Conference on Carbonic Anhydrases, 2018, Bucharest, Romania.

- 4th Satellite Meeting on Carbonic Anhydrases, 2019, Parma, Italia.

- 39° Congresso Nazionale SIF – Società Italiana di Farmacologia, 2019, Firenze, Italia.

- 12th International conference on Carbonic Anhydrases, 2023, Naples, Italia.

- SYNC2024, 2024, Rome, Italia.

SCIENTIFIC PRODUCTION

- 259 research articles/reviews in peer-reviewed journals.

- 14 book chapters.

- Editor of 1 research monograph: “Carbonic Anhydrases: Biochemistry and Pharmacology of an Evergreen Pharmaceutical Target”, Academic Press Publisher, Elsevier, 2019. pp. 560. Paperback ISBN: 9780128164761

- 3 patents and 2 patent applications.

BIBLIOMETRIC INDICATORS

H-index (Scopus, Scholar) 45, 48

Citations (Scopus, Scholar) 6879, 7869

GRANTS

- Principal Investigator: “MuTaG4L”, Prin2022, MIUR (2023-2025).

- Co-Principal Investigator: “CUTESANA” – Bando di Ateneo, UNIFI (2023-2025).

- Member of Local Unit “FISR2019_04819 BacCAD” – FISR (Fondo integrativo speciale per la ricerca), MIUR (2020-2023).

- Member of Local Unit “Targeting di strutture G-quadruplex di acidi nucleici e anidrasi carbonica per lo sviluppo di strategie terapeutiche tumorali multibersaglio” – Bando Fondazione Intesa San Paolo 2021 (2022-2022).

- Member of Local Unit “Springboard for excellence in advanced development of antibacterials” – European Commission, Horizon 2020 (2020-2023).

- Member of Local Unit “β3-adrenoreceptor as progostic marker in Neuroblastoma and Ewing Sarcoma (BETA3TUMPED)” – Bando Salute 2018 Regione Toscana (2020-2023).

- Member of Local Unit: THE (Tuscany Health Ecosystem), Spoke 8 – PNRR (2022-2025).

PRIZES AND AWARDS

2018 Best PhD Prize 2018, Italian Chemical Society, Medicinal Chemistry Division

2020 Best Oral Communication, IV satellite meeting on Carbonic Anhydrases 2019, Parma, Italy

NATIONAL SCIENTIFIC QUALIFICATION

2019 Abilitazione Scientifica Nazionale SC: 03/D1-Fascia 2,17/09/2019 - 17/09/2028