Il Dott. Bartolini è in servizio presso l’Azienda Ospedaliera Universitaria Meyer IRCCS e Università di Firenze, ed è uno dei pochi medici in Europa ad aver ottenuto la certificazione per la diagnosi e cura in Neurologia pediatrica ed Epilessia negli Stati Uniti d’America dalla American Board of Psychiatry and Neurology (ABPN) e ad avere ottenuto il titolo di Fellow of the American Academy of Neurology (FAAN) e Fellow of the American Epilepsy Society (FAES) in riconoscimento dei suoi raggiungimenti professionali e dedizione alla cura delle patologie neurologiche.

Il Dott. Bartolini è un leader accademico che ha acquisito più di 12 anni di esperienza in pratica clinica, ricerca, amministrazione e management negli USA prima di rientrare in Italia. La sua area di expertise è il trattamento dell’epilessia pediatrica, inclusa l’epilessia farmacoresistente e la valutazione per chirurgia dell’epilessia.

Prima di trasferirsi all’Azienda Ospedaliera Universitaria Meyer IRCCS, il Dott. Bartolini è stato direttore del programma di epilessia pediatrica presso Hasbro Children’s Hospital e professore assistente di pediatria, neurologia e neurochirurgia presso la Warren Alpert Medical School della Brown University, università della Ivy League negli Stati Uniti. Sotto la sua guida, il programma è diventato un centro di riferimento per il trattamento delle epilessie pediatriche complesse nel Rhode Island, nel Massachusetts meridionale e nel Connecticut orientale. Ha costituito un team multidisciplinare, in grado di eseguire test diagnostici all’avanguardia e trattamenti avanzati. Il programma chirurgico ha offerto molteplici opzioni ai bambini affetti da epilessia resistente ai farmaci, compreso il monitoraggio EEG invasivo con EEG stereotassico, chirurgia resettiva, ablazione laser stereotassica guidata da MRI e impianto di dispositivi di neuromodulazione. Tra i tanti successi, il team del dottor Bartolini è stato il secondo nel New England a impiantare un dispositivo di neurostimolazione responsivo (RNS) in un bambino, che è poi diventato libero da crisi epilettiche senza deficit postoperatori.

Le aree di ricerca del Dott. Bartolini comprendono i meccanismi di neuroinfiammazione e le caratteristiche genetiche coinvolte nell’epilessia pediatrica e le caratteristiche elettrofisiologiche di malattie genetiche rare.

La sua ricerca è stata supportata da Advance-CTR e Children’s Miracle Network presso la Brown University, dall’American Epilepsy Society, dall’Epilepsy Foundation of America e dalla Divisione di ricerca intramurale del National Institute of Neurological Disorders and Stroke (NINDS).

Il dottor Bartolini ricopre il ruolo di editore capo di Neurology: Clinical Practice e editore associato di Neurology (riviste ufficiali dell’American Academy of Neurology) e fa parte del sottocomitato per lo sviluppo della leadership e del comitato delle pubblicazioni dell’American Academy of Neurology.

Il Dott. Bartolini è stato coinvolto in numerosi progetti di ricerca clinica e traslazionale riguardanti l’epilessia, spaziando dallo studio dei meccanismi virali e infiammatori coinvolti nella fisiopatologia dell’epilessia alle caratteristiche di imaging dell’epilessia pediatrica farmacoresistente e al ruolo dell’infiammazione nello stato di male epilettico superrefrattario nei bambini. Più recentemente, l’obiettivo della ricerca del Dr. Bartolini è stato quello di analizzare le caratteristiche neurofisiologiche delle epilessie genetiche rare e di decodificare l’espressione genetica in campioni cerebrali resecati chirurgicamente da bambini affetti da encefalite di Rasmussen, una forma rara e devastante di epilessia resistente ai farmaci.

L’obiettivo generale della ricerca del Dott. Bartolini è quello di chiarire i meccanismi patologici coinvolti nello sviluppo dell’epilessia farmacoresistente nei bambini, con lo scopo di tradurre queste scoperte nella pratica clinica come potenziali bersagli per nuovi approcci terapeutici e, in definitiva, di migliorare la qualità della vita dei bambini colpiti da questa grave condizione e delle loro famiglie.

Dr. Bartolini is an American Board of Psychiatry and Neurology (ABPN) dual Board-Certified Pediatric Neurologist and Epileptologist practicing at Meyer Children’s Hospital / University of Florence, Italy.

Dr. Bartolini is an academic leader who has acquired more than 12 years of experience in clinical practice, research, administration and management in the USA before moving back to Italy. His area of expertise is the treatment of complex neurological disorders in children, with a special interest in all forms of childhood epilepsy, including rare, drug-resistant neurogenetic conditions, inflammatory disorders affecting the central nervous system, pediatric stroke and neurocritical care.

In recognition of his professional accomplishments and dedication in the field of neurology and epilepsy, Dr. Bartolini has been elected a Fellow by the American Academy of Neurology and by the American Epilepsy Society, an honor that only few doctors in Europe have received.

Before joining Meyer Children’s, Dr. Bartolini was the Director of the Pediatric Epilepsy Program at Hasbro Children’s Hospital and Assistant Professor of Pediatrics, Neurology and Neurosurgery at the Warren Alpert Medical School of Brown University, United States. Under his leadership, the program has become a referral center for the treatment of complex pediatric epilepsies in Rhode Island, Southern Massachusetts, and Eastern Connecticut. He established a multidisciplinary team, with the ability to perform cutting-edge diagnostic tests, and advanced treatments. The surgical program offered multiple options to children with drug-resistant epilepsy, including invasive EEG monitoring with stereotactic EEG, resective surgery, MRI-guided stereotactic laser ablation, and implantation of neuromodulation devices. Amongst many achievements, Dr. Bartolini’s team was the second in New England to implant a responsive neurostimulation device (RNS) in a child, who then became seizure-free without postoperative deficits.

Dr. Bartolini’s areas of research include inflammatory mechanisms and genetic features involved in pediatric epilepsy and electrophysiological features of rare genetic conditions. His research has been supported by Advance-CTR, and Children’s Miracle Network at Brown University, the American Epilepsy Society, Epilepsy Foundation of America and by the Division of Intramural Research of the National Institute of Neurological Disorders and Stroke (NINDS).

Dr. Bartolini serves as Editor-In-Chief of Neurology: Clinical Practice and Associate Editor of Neurology (official journals of the American Academy of Neurology), and sits on the Leadership Development Subcommittee and Publications Committee of the American Academy of Neurology.

 CURRICULUM VITAE

LUCA BARTOLINI, MD, FAAN, FAES

Work email:

luca.bartolini@meyer.it

luca.bartolini@unifi.it

EDUCATION:

Undergraduate         Liceo Classico “Tito Livio”, Padova, Italy

Medical School        University of Padova School of Medicine, Padova, Italy

                                    09/2000 – 07/2006

Doctor of Medicine (M.D.)

POSTGRADUATE TRAINING:

Residency                Obstetrics and Gynecology

                                    University of Parma, Italy

                                    07/2007 – 01/2008

                                    Pediatrics (Pediatric Neurology Track)

                                    University of Padova, Italy

                                    04/2008 – 10/2013

                                    Pediatrics

Children’s National Medical Center / The George Washington University, Washington DC

07/2012 – 06/2013

Fellowship               Child Neurology

Children’s National Medical Center / The George Washington University, Washington DC

07/2013 – 06/2016

Neuroscience Research

Children’s National Medical Center / The George Washington University, Washington DC

National Institutes of Health, Bethesda, MD

07/2016 – 06/2017

Epilepsy

National Institutes of Health, Bethesda, MD

07/2017 – 06/2018

Clinical Neurophysiology

National Institutes of Health, Bethesda, MD

07/2018 – 06/2019

POSTGRADUATE HONORS AND AWARDS:  

Research Career Symposium Scholarship

American Academy of Neurology

02/2015

Pediatric Epilepsy Fellow Pipeline Travel Scholarship

Epilepsy Foundation of America

12/2015

Sentinel of Science Award (Top 10% of Researchers contributing to the peer-review of the field of Medicine)

Publons

2016

Publons Peer Review Awards (Top 1% of peer reviewers in Medicine)

Publons

2017

“Kevin Fellow” award ( https://www.epilepsy.com/about-us/research-and-new-therapies/kevins-fellows )

                                    Epilepsy Foundation of America

                                    09/2017

                                    Emerging Leaders Program selectee ( https://www.aan.com/conferences-community/leadership-programs/emerging-leaders/ )

                                    American Academy of Neurology

                                    10/2019 – 05/2020

                                    “Hasbro Brite Lite” award ( https://www.lifespan.org/locations/hasbro-childrens-hospital/about-hasbro-childrens-hospital/awards/brite-lites/brite-lite-prev-winners )

                                    Hasbro Children’s Hospital, Providence, RI

                                    3/2020

                                    Leadership Excellence Advancement Program (LEAP) selectee

                                    Hasbro Children’s Hospital, Providence, RI

                                    4/2021

                                    Rhode Island Monthly “2022 Top Docs” award

                                    Rhode Island Monthly “2023 Top Docs” award

                                    https://www.rimonthly.com/be-well-rhody/top-doctors/

                                    Elected Fellow of the American Academy of Neurology (FAAN)

                                    https://www.aan.com/membership/become-a-fellow-faan

7/2023

Elected Fellow of the American Epilepsy Society (FAES)

https://aesnet.org/membership/get-involved/faes

10/2023

BOARD CERTIFICATIONS:

Italian National Board Certification in Pediatrics

03/2013

American Board of Psychiatry and Neurology (ABPN): Board certification in Neurology with special qualification in Child neurology

Certificate No. 12625         

09/11/2017

American Board of Psychiatry and Neurology (ABPN): Board certification in Epilepsy

Certificate No. 1578

10/22/2018

American Board of Psychiatry and Neurology (ABPN): Board eligible in Clinical Neurophysiology

Present

Abilitazione Scientifica Nazionale alle funzioni di professore universitario di seconda fascia nel Settore Concorsuale 06/G1 – Pediatria Generale, Specialistica e Neuropsichiatria Infantile (Italian National certification for Associate Professorship in Pediatrics and Child Neurology)

02/07/2022 – 02/07/2033

PROFESSIONAL LICENSES

Italian National Medical License                                      

02/2007

Educational Commission for Foreign Medical Graduates (ECFMG) certification                        

02/2012

Unrestricted license to practice Medicine in the District of Columbia

01/2017 – 12/2020

Unrestricted license to practice Medicine in Rhode Island

11/2018 - present

ACADEMIC APPOINTMENTS

Research Instructor of Pediatrics

The George Washington University School of Medicine and Health Sciences

11/2013 – 06/2017

Assistant Professor of Pediatrics

Assistant Professor of Neurology

Assistant Professor of Neurosurgery

The Warren Alpert Medical School of Brown University

8/1/2019 – 6/30/2023

Assistant Professor of Child Neurology (RTDb)

University of Florence, Italy

10/1/2023 - present

HOSPITAL APPOINTMENTS

                                    Director, Pediatric Epilepsy Program

                                    Attending Pediatric Neurologist and Epileptologist

                                    Hasbro Children’s Hospital, Providence, RI

6/30/2019 – 6/30/2023

Attending Pediatric Neurologist / Epileptologist

Meyer Children’s Hospital, Florence, Italy

10/1/2023 - present

EDITORIAL APPOINTMENTS

Member of the Editorial Board, Neurology - Resident & Fellow Section

10/2014 – 10/2017

Ad hoc reviewer for Neurology

1/2014 – 9/2021

Section Editor, Neurology Clinical Practice

                                    American Academy of Neurology

                                    4/2015 – 9/2021

                                    https://www.neurology.org/collection/practice_current

https://www.neurology.org/practicebuzz/landing

Member of the Editorial Board, Frontiers in Neurology / Frontiers in Pediatrics           

10/2016 – 9/2021

Editor-in-Chief, Neurology: Clinical Practice

                                    American Academy of Neurology

10/2021 – 10/2031

Associate Editor, Neurology

American Academy of Neurology

10/2021 – 10/2031

GRANT REVIEWER

2021 University of Puerto Rico (UPR) ALLIANCE Pilot Projects Program (PPP) reviewer

2022 American Academy of Neurology (AAN) Research Programs reviewer

HOSPITAL COMMITTEES:

                                    Member of the Clinical Fellows Committee

                                    National Institutes of Health

                                    09/2017 – 6/30/2019

                                    Co-Chair of the Status Epilepticus Task Force

                                    Hasbro Children’s Hospital

                                    09/2019 – 6/30/2023

Member of the Pediatric Intensive Care Unit Division Director search committee

Hasbro Children’s Hospital

12/2020 – 11/2021

PROFESSIONAL ORGANIZATIONS COMMITTEES:

Member of the Education on demand workgroup (eLearning Subcommittee)

                                    American Academy of Neurology

                                    11/2017 – 12/2019

                                    Member of the Pediatric Content Committee

                                    American Epilepsy Society

                                    11/6/2019 – 11/2022

Member of the ad hoc workgroup on Pediatric Epilepsy Resources and contributor to “Considerations for reopening Pediatric Epilepsy Monitoring Units during the COVID-19 pandemic”

American Epilepsy Society

4/2020 – 9/2020

Member of the Emerging Leaders Program (ELP) Participant Selection Workgroup

American Academy of Neurology

10/10/2020 – present

Member of the Leadership Engagement Subcommittee

American Academy of Neurology

4/24/2021 – present

Member of the Publications Committee

American Academy of Neurology

10/2021 - present

MEMBERSHIP IN SOCIETIES:

                                    American Academy of Neurology

2013 – present

American Epilepsy Society                                                                                      2015 – present

Child Neurology Society                                                                                         2016 – present

PUBLICATIONS LIST:

ORIGINAL PUBLICATIONS IN PEER-REVIEWED JOURNALS:

1. Suppiej A, Festa I, Bartolini L, Cappellari A, Trevisanuto D, Ermani M. Power spectral analysis of two-channel EEG in very preterm infants undergoing heat loss prevention. Clin Neurophysiol 2011;122(S1):S22.
2. Bartolini L, Gentilomo C, Sartori S, Calderone M, Simioni P, Laverda AM. Varicella and Stroke in Children: Good Outcome Without Steroids. Clin Appl Thromb Hemost 2011;17(6):E127-30.
3. Bartolini L, Mardari R, Toldo I, Calderone M, Battistella PA, Laverda AM, Sartori S. Norovirus Gastroenteritis and Seizures: An Atypical Case with Neuroradiological Abnormalities. Neuropediatrics 2011;42(4):167–169.
4. Toldo I, De Carlo D, Mardari R, De Palma L, Gatta M, Bolzonella B, Nosadini M, Bartolini L, Sartori S, Battistella PA. Short lasting activity-related headaches with sudden onset in children: a case-based reasoning on classification and diagnosis. J Headache Pain 2013;14:3.
5. Bartolini L, Sartori S, Lenzini E, Rigon C, Cainelli E, Agrati C, Toldo I, Donà M, Trevisson E. De novo trisomy 20p characterized by array comparative genomic hybridization: Report of a novel case and review of the literature. Gene 2013;524(2):368-72.
6. Suppiej A, Festa I, Bartolini L, Cappellari A, Cainelli E, Ermani M, Trevisanuto D. Power spectral analysis of two-channel EEG in very premature infants undergoing heat loss prevention. Neurophysiol Clin 2014;44(3):239-44.
7. Bartolini L, Burger K. Pearls & Oy-sters: Cerebral venous air embolism after central catheter removal: Too much air can kill. Neurology 2015;84(13):e94-6.
8. Sanapo L, Bartolini L, Chang T, Vezina G. Giant Fetal Arachnoid Cyst with Favorable Neurological Outcome. Neurology 2015;84(20):e160-1.
9. Farias-Moeller R, Bartolini L, Pasupuleti A, Brittany Cines RD, Kao A, Carpenter JL. A Practical Approach to Ketogenic Diet in the Pediatric Intensive Care Unit for Super-Refractory Status Epilepticus. Neurocrit Care 2017;26(2):267-272.
10. Bartolini L, Kao A, Zachery A, Murnick J, Gaillard WD. Homotopic motor distribution on fMRI in closed-lip schizencephaly. Neurology 2017;88(2):e24-e25.
11. Bartolini L, Whitehead MT, Ho C, Sepeta LN, Oluigbo CO, Havens K, Freilich ER, Schreiber JM, Gaillard WD. Temporal lobe epilepsy and focal cortical dysplasia in children: A tip to find the abnormality. Epilepsia 2017;58(1):113-122.
12. Bartolini L, Muscal E. Differences in Treatment of Anti-NMDA Receptor Encephalitis: Results of a Worldwide Survey. J Neurol 2017;264(4):647-653.
13. Farias-Moeller R, Bartolini L, Staso K, Schreiber JM, Carpenter JL. Early Ictal and Interictal patterns in FIRES: The Sparks Before the Blaze. Epilepsia 2017;58(8):1340-1348.
14. Bartolini L, Majidi S, Koubeissi MZ. Uncertainties from a Worldwide Survey on Antiepileptic Drug Withdrawal After Seizure Remission. Neurol Clin Pract 2018;8(2):108-115.
15. Badran A, Bartolini L, Ksendzovsky A, Ray-Chaudhury A, Abdennadher M, Zaghloul KA, Inati SK. Transient postictal blindness after a focal posterior cingulate gyrus seizure. Seizure 2018;54:58-60.
16. Farias-Moeller R, LaFrance-Corey R, Bartolini L, Wells E, Baker M, Doslea A, Suslovic W, Greenberg J, Carpenter JL, Howe C. Fueling the FIRES: Hemophagocytic lymphohystiocytosis in patients with Febrile Infection-Related Epilepsy Syndrome. Epilepsia 2018;59(9):1753-1763.
17. Bartolini L, Piras E, Sullivan K, Gillen S, Bumbut A, Lin CT, Leibovitch EC, Graves J, Waubant EL, Chamberlain JM, Gaillard WD, Jacobson S. HHV6 and EBV DNA detection and increased cytokine levels in saliva from children with seizures. Front Neurol 2018. Front Neurol. 2018;9:834.
18. George IC, Bartolini L, Ney J, Singhal D. Differences in treatment of epilepsy in pregnancy: A worldwide survey. Neurol Clin Pract. 2019;9(3):201–207.
19. Bartolini L, Theodore WH, Jacobson S, Gaillard WD. Infection with HHV-6 and its role in epilepsy. Epilepsy Res. 2019;153:34–39.
20. Bartolini L, Libbey JE, Ravizza T, Fujinami RS, Jacobson S, Gaillard WD. Viral Triggers and Inflammatory Mechanisms in Pediatric Epilepsy. Mol Neurobiol. 2019;56(3):1897–1907.
21. Ganesh A, Bartolini L, Wesley SF. Worldwide survey of neurologists on approach to autoimmune encephalitis. Neurol Clin Pract. 2020;10(2):140-148.
22. Asadi-Pooya AA, Bartolini L. Prevention and treatment of temporal lobe epilepsy: lessons from hepatitis B story. Int J Neurosci 2020;130(11):1151-1155.
23. Warrior L, Kim CY, Burdick DJ, Ackerman DJ, Bartolini L, Cagniart KR, Dangayach NS, Dawson ET, Orjuela KD, Gordon Perue GL, Cutsforth-Gregory JK, Bahouth MN, McClean JC 2nd, DeLuca GC. Leading with inclusion during the COVID-19 pandemic: Stronger together. Neurology. 2020;95(12):537-542.
24. Raimondo E, McKinney R, Mason K, Bartolini L. Teaching Video Neuroimages: Ictal unilateral eye blinking in temporal lobe seizures: An illustrative video case. Neurology. 2021;96(7):e1094-e1095.
25. Phillips O, Radoeva P, Bartolini L. Delayed transhemispheric propagation of electrographic seizures following functional hemispherectomy. Clin Neurol Neurosurg. 2021;201:106418.
26. Bartolini L. Mechanisms of neuroinflammation in epilepsy linked to HHV-6 infection. Drug Discov Today. 2020; 32(Part A):53-57.
27. Abdennadher M, Inati S, Soldatos A, Norato G, Baker EH, Thurm A, Bartolini L, Masvekar R, Theodore W, Bielekova B, Porter FD, Dang Do AN. Seizure phenotype in CLN3 disease and its relation to other neurologic outcome measures. J Inherit Metab Dis. 2021;44(4):1013-1020.
28. Ganesh A, Bartolini L, Singh RJ, Al-Sultan AS, Campbell DJT, Wong JH, Menon BK. Equipoise in Management of Patients With Acute Symptomatic Carotid Stenosis (Hot Carotid). Neurol Clin Pract. 2021;11(1):25-32.
29. Wiwattanadittakul N, Suwannachote S, You X, Cohen NT, Tran T, Phuackchantuck R, Tsuchida TN, Depositario-Cabacar DF, Zelleke T, Schreiber JM, Conry JA, Kao A, Bartolini L, Oluigbo C, Almira-Suarez MI, Havens K, Whitehead MT, Gaillard WD. Spatiotemporal distribution and age of seizure onset in a pediatric epilepsy surgery cohort with cortical dysplasia. Epilepsy Res. 2021;172:106598.
30. Bartolini L, Moran MP, Norato G, Thomas B,  Dick DA, Wells E, Suslovic W, Bumbut A, Chamberlain JM, Theodore WH, Gaillard WD, Jacobson S. Differential Activation of Neuroinflammatory Pathways in Children with Seizures: A Cross-Sectional Study. Seizure. 2021;91:150-158.
31. Watson G, Afra P, Bartolini L et al.A Journey into the Unknown: An Ethnographic Examination of Drug-resistant Epilepsy Treatment Management in the United States. Epilepsy Behav 2021;23;124:108319.
32. Erlich-Malona N, Bartolini L, D’Abreu A, Roth J. Paroxysmal Hypothermia With Prominent Parkinsonian Features After Suprachiasmatic Tumor Resection. Neurohospitalist. 2022;12(2):285-289.
33. Samanta D, Ostendorf AP, Singh R, Gedela S, Elumalai V, Hoyt ML, Perry MS, Bartolini L, Curran GM. Physicians' Perspectives on Presurgical Discussion and Shared Decision-Making in Pediatric Epilepsy Surgery. J Child Neurol.2022;37(5):416-425.
34. Lob K, Bassell-Hawkins J, Patil R, Nie D, Bartolini L. Vitamin B6 decreases the risk of levetiracetam discontinuation in children with epilepsy: A retrospective study. Epilepsy Behav. 2022;134:108839.
35. Shao B, Zheng B, Liu DD, Anderson MN, Svokos K, Bartolini L^*, Asaad WF*. Seizure freedom after laser amygdalohippocampotomy guided by bilateral responsive neurostimulation in pediatric epilepsy: illustrative case. J Neurosurg Case Lessons. 2022;4(9):CASE22235.
36. Amianto F, Davico C, Bertino F, Bartolini L, Vittorini R, Vacchetti M, Vitiello B. Clinical and Instrumental Follow-Up of Childhood Absence Epilepsy (CAE): Exploration of Prognostic Factors. Children (Basel). 2022;9(10):1452.
37. Lob K, Hou T, Chu TC, Ibrahim N, Bartolini L, Nie D. Clinical features and drug-resistance in pediatric epilepsy with co-occurring autism: A retrospective comparative cohort study. Epilepsy Behav 2023;143:109228.
38. Abdennadher M, Patel S, Dembny K, Edalatpour R, Weinberg J, Bartolini L, Ganesh A, Singhal D. Work, Parenting, and Well-being: An International Survey of Neurologists During the COVID-19 Pandemic. Neurol Clin Pract 2023;13(5):e200176.
39. Zheng B, Abdulrazeq H, Shao B, Liu DD, Leary O, Lauro PM, Bartolini L, Blum AS, Asaad WF. Seizure and anatomical outcomes of repeat laser amygdalohippocampotomy for temporal lobe epilepsy: A single-institution case series. Epilepsy Behav 2023;146:109365.

PUBLISHED SUBMITTED/UNDER REVIEW

1. Bartolini L, Chan F, Lob K, Wu Q, Gamsiz Uzun E, Oluigbo C, Gaillard WD, Mathern GW, Liu JS. Analysis Of Differentially Expressed Inflammatory and Non-Inflammatory Pathways By RNA-Sequencing In Rasmussen Encephalitis. 2023, manuscript under review.

PUBLISHED PEER-REVIEWED COMMENTARIES

1. Bartolini L. Practice Current: How Do You Treat Anti-NMDA receptor Encephalitis? Neurol Clin Pract 2016;6(1):69-72.
2. Bartolini L. Practice Current: What is your diagnostic evaluation of cryptogenic stroke? Neurol Clin Pract 2016;6(3):271-276.
3. Bartolini L. Practice Current: When do you stop antiepileptic drugs in patients with genetic generalized epilepsies and in those with focal epilepsies? Neurol Clin Pract 2016;6(6):530-537.

PUBLISHED BOOK CHAPTERS

1. Bartolini L, Kline J (2020). Acute Ataxia. Chapter 15. In: Bachur, Richard G.; Shaw, Kathy N.; Chamberlain, James (Ed.). Fleisher & Ludwig's Textbook of Pediatric Emergency Medicine, 8^th Edition. Lippincott Williams & Wilkins (LWW). ISBN: 978-1-97-512151-8.

PUBLISHED EDITORIALS/LETTERS

1. Bartolini L, Millichap J. Editorial. Practice Current: A New Way of Interpreting Contemporary Neurology. Neurol Clin Pract 2016;6(1):14-15.
2. Bartolini L. Editorial. Practice Current: Establishing Worldwide Connections. Neurol Clin Pract 2016;6(6):470-471.
3. Bartolini L. "Curious George Goes to the Hospital": teaching toddlers how good healthcare works. BMJ. 2018;360:k487.
4. Bartolini L. Author Response: Uncertainties from a worldwide survey on antiepileptic drug withdrawal after seizure remission. Neurol Clin Pract 2018;8(4).
5. Bartolini L. Inclusion as a Key to Shaping the Future of Neurology Clinical Practice: Calling for Authors. Neurol Clin Pract. 2021;11(6):453-454.
6. Zea Vera A, Bartolini L, Ganesh A. Picking Brains on a Global Scale: Practice Current and Practice Buzz. Neurol Clin Pract. 2022;12(4):e33-e34.
7. Bartolini L. Neurology Clinical Practice: Laying a Foundation to Become the Primary Home for Quality-Oriented Research in Neurology. Neurol Clin Pract. 2022;12(6):383-385.

PUBLISHED ABSTRACTS:

1. Anfuso S, Quarantelli E, Patrelli TS, Bartolini L et Al. Neonatal outcome in patients with preterm labor under tocolytic therapy vs. expectant management. J Perinat Med 2007;35(S2):106.
2. Anfuso S, Gagliano N, Bartolini L, Patrelli TS et Al. Growth discordance in twin pregnancies: a study on 280 newborns. J Perinat Med 2007;35(S2):55.
3. Bartolini L, Richardson PK. Unusual presentation of Hirayama’s disease in a middle-aged Spanish woman. Muscle Nerve 2014;50(4):626.
4. Bartolini L, Whitehead M, Ho CY, Sepeta L, Oluigbo C, Havens K, Freilich E, Schreiber J, Gaillard WD. Temporal lobe epilepsy and focal cortical dysplasia in children: MRI findings and pathology. 2015 AES annual meeting proceedings. Abstract 3.301.
5. Bartolini L, Leibovitch E, Vellucci A, Lin CT, Chamberlain J, Sullivan K, Bumbut A, Thomas B, Wells E, Ziobro J, Gaillard WD, Jacobson S. Viral markers in children with seizures: preliminary data from a prospective observational hypothesis generating study. 2016 AES annual meeting proceedings. Abstract 1.084.
6. Suwannachote S, Wiwattanadittakul N, You X, Whitehead MT, Oluigbo C, Tsuchida TN, Depositario-Cabacar D, Zelleke T, Schreiber JM, Kao A, Conry JA, Vu T, Bartolini L, Havens K, Boutzoukas E, Gaillard WD. Age-related clinical onset with volume of brain imaging in focal cortical dysplasia and hemimegalencephaly of intractable childhood epilepsy. 2017 AES annual meeting proceedings. Abstract 1.231.
7. Farias-Moeller R, Bartolini L, Wells E, Baker M, Doslea A, Suslovic W, Greenberg J, Howe C, Carpenter JL. Fueling the FIRES: Hemophagocytic lymphohystiocytosis in patients with Febrile-Infection Related Epilepsy Syndrome. 2017 AES annual meeting proceedings. Abstract 2.159.
8. Bartolini L, Piras E, Sullivan K, Gillen S, Lin CT, Leibovitch E, Chamberlain J, Gaillard WD, Jacobson S. Detection of HHV-6 and EBV and cytokine expression in saliva from children with seizures: results of a cross-sectional study. 2017 AES annual meeting proceedings. Abstract 1.068.
9. Bartolini L, Moran MP, Leibovitch E, Thomas B, Dick AD, Wells E, Suslovic W, Bumbut A, Chamberlain J, Gaillard WD, Jacobson S. Proinflammatory cytokines in blood from children with seizures: preliminary results of a cross-sectional study. 2018 AES annual meeting proceedings. Abstract 3.087.
10. Gordon T, Squirewell C, Abdennadher A, Brownrout J, Bartolini L, Inati SK, Thurm A, Khan OI.Comparative Analysis Using Global EEG Topography of Brain Resting States in Children. 2019 AES annual meeting proceedings. Abstract 3.177.
11. Squirewell C, Gordon T, Abdennadher A, Bartolini L, Inati SK, Brownrout J, Khan OI.Comparative Analysis Using Global EEG Topography of Brain Resting States in Patients with Multi-Drug Resistant Temporal Lobe Epilepsy. 2019 AES annual meeting proceedings. Abstract 1.189.
12. Bartolini L, Moran MP, Norato G. et al. Differential Activation of Neuroinflammatory Pathways in Children with Seizures. 2019 AES annual meeting proceedings. Abstract 1.081.
13. Bartolini L, Chan F, Wu Q, Gamsiz E, Oluigbo C, Gaillard W, Liu J. Differential gene expression analysis of RNA-sequencing data in Rasmussen encephalitis. 2020 AES annual meeting proceedings. Abstract 394.
14. Chan F, Bartolini L, Wu Q, Usai SE, Chan B, Lewis C, Uzun E, Neretti N, Oluigbo C, Gaillard WD, Liu JS.Integrated transcriptomics-metabolomics analysis implicates dysfunction of lysine metabolism in tuberous sclerosis complex. 2020 AES annual meeting proceedings. Abstract 218.
15. Lala N, Kanach C, Montalvo-Perero M, Welsh S, Brown W, Bartolini L, Delalle I, Patil R. multilobar focal cortical dysplasia type iia in a child presenting with febrile infection-related epilepsy syndrome (FIRES). 2020 AES annual meeting proceedings. Abstract 827.
16. Lob K, Nie D, Patil R, Murillo A, Bartolini L. Analysis of Levetiracetam Side-Effects Leading to Discontinuation of Therapy and Role of Vitamin B6 in Pediatric Epilepsy. 2021 AES annual meeting proceedings.
17. Chan F, Bartolini L, Wu Q, Evans S, Usai E, Chan B, Tan Y, Uzun D, Neretti N, Lewis C, Shaffer S, Oluigbo C, Gaillard WD, Liu JS. Finding a Common Metabolic Signature of Focal Pediatric Epilepsy. 2021 AES annual meeting proceedings.
18. MacLean D, Beland B, Jewett G, Bartolini L, Campbell DJT, Varma M, Singh R, Al-Sultan A, Wong J, Menon B, Ganesh A. Physician Approaches to the Initial Management of an Intraluminal Thrombus in Recently Symptomatic Carotid Artery Stenosis: Results from the Hot Carotid Study. 2023 AAN annual meeting proceedings.
19. Roberts J, Ganesh A, Bartolini L, Kalincik T. Approach to Balancing Risk in Multiple Sclerosis Management: a Worldwide Practice Survey. 2023 AAN annual meeting proceedings.
20. Bartolini L, Chan F, Lob K, Wu Q, Ece Uzun D, Oluigbo C, Gaillard WD, Chang J, Mathern G, Liu JS. Analysis Of Differentially Expressed Genes By RNA-Sequencing In 38 Cases of Rasmussen Encephalitis: New Insights on Non-Inflammatory Pathways. 2023 AAN annual meeting proceedings.

SCHOLARLY WORK PUBLISHED ONLINE:

1. Bartolini L, Richardson PK. “Unusual presentation of Hirayama’s disease in a middle-aged Spanish woman”. Online CME case study for the American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM). Available at: https://www.aanem.org/Education/All-Education-Products/Product-Details?productid={3488B316-4177-E511-BAA1-00155D0A6803}

PODCASTS (as invited speaker):

1. Journal of Child Neurology podcast. July 12, 2022. Available at: https://sageneuroscience.libsyn.com/jcn
2. Neurology journal podcast. March 29, 2016. Available at: https://neurology.libsyn.com/website/march-29-2016-issue

PODCASTS (as Editor/Moderator):

1. Neurology journal podcast. July 1, 2020. Available at http://neurology.aan.libsynpro.com/website/diagnosis-and-management-of-post-concussive-headache-practice-current-july-2020

2. Neurology journal podcast. March 29, 2019. Available at

https://neurology.libsyn.com/website/practice-current-autoimmune-encephalitis-the-role-of-antibody-testing

3. Neurology journal podcast. April 2, 2018. Available at:

https://neurology.libsyn.com/website/practice-current-managing-epilepsy-during-pregnancy-april-2018

4. Neurology journal podcast. June 1, 2017. Available at:

https://neurology.libsyn.com/website/practice-current-antiepileptic-drug-discontinuation

5. Neurology journal podcast. September 30, 2017. Available at:

https://neurology.libsyn.com/website/delayed-recall-practice-current-treatment-of-neuromyelitis-optica-october-2017

INVITED PRESENTATIONS:

INTERNATIONAL:

1. Speaker: Luca Bartolini, MD. “Growth discordance in twin pregnancies: a study on 280 newborns”.

8^th World Congress of Perinatal Medicine, Florence (Italy)                 

09/2007

1. Speaker: Luca Bartolini, MD. “Asymptomatic abruptio placentae”

83^rd Italian Society of Obstetrics and Gynecology National Congress, Naples (Italy)              

10/2007

2. Speaker: Luca Bartolini, MD. “HeadTalks: Neurology Clinical Practice: Practice Current”

68^th Annual Meeting, American Academy of Neurology (AAN), Vancouver (Canada)

4/2016

3. Speaker: Luca Bartolini, MD. “Practice Current: Share your Best Practices and Compare in Real-time with International Peers and Experts”

69^th Annual Meeting, American Academy of Neurology (AAN), Boston, MA

4/2017

4. Speaker: Luca Bartolini, MD. “Headtalks. How does your practice fare when compared to international peers and experts?”

69^th Annual Meeting, American Academy of Neurology (AAN), Boston, MA

4/2017

5. Investigators Workshop. Inflammation and Epilepsy: where do we stand and where do we go from here? Speakers: Luca Bartolini, MD; Annamaria Vezzani, PhD; Jacqueline French, MD Moderator: William H. Theodore, MD

2017 American Epilepsy Society (AES) Annual Meeting, Washington, DC (USA)

12/2017

6. Speaker: Luca Bartolini, MD. “The Role of Inflammation in Epilepsy: Biomarkers and New Therapeutic Targets”

University of Turin, Italy

7/2018

7. Speaker: Luca Bartolini, MD. “The Role of Inflammation in Epilepsy: Biomarkers and New Therapeutic Targets”

University of Padua, Italy

7/2018

8. Speaker: Luca Bartolini, MD. “The Role of Inflammation in Epilepsy: Biomarkers and New Therapeutic Targets”

Carlo Besta Neurological Institute, Milan, Italy

7/2018

9. Speaker: Luca Bartolini, MD. “Ontogeny of semiology: transitional signs from pediatrics to adulthood”.

2020 American Clinical Neurophysiology Society (ACNS) Annual Meeting, New Orleans, LA (USA)

2/2020

1. Organizer/moderator: Bartolini, L. “Epilogo 2020: Bringing Junior Investigators and Clinicians Together To Talk About Translational Science in Epilepsy”. Italian League Against Epilepsy webinar. 7/11/2020 (virtual due to COVID19)
2. Speaker: Luca Bartolini, MD. Immune-Mediated Epilepsies. Virtual Symposium of Pediatric Neuroimmunology. Colombian Association of Child Neurology (ASCONI). 11/21/2020 (virtual due to COVID19)
3. Speaker and session Director: Luca Bartolini, MD. “Transforming Health Care Delivery in Neurology”. Practice and Policy Hub.

2023 American Academy of Neurology Annual Meeting, Boston, MA (USA)

4/23/2023

NATIONAL (USA):

1. Speaker: Luca Bartolini, MD. “Anti-NMDAr Encephalitis after HSV Encephalitis”

Professorial Rounds, Children’s National Hospital, Washington DC (USA)

1/2016

2. Speaker: Luca Bartolini, MD. “Treatment of anti-NMDAr encephalitis: results of a worldwide survey”

Building Bridges: Pediatric Autoimmune Encephalitis Treatment Consensus Meeting, Washington DC (USA)

11/2016

2. Speaker: Luca Bartolini, MD. “When ADHD is the Tip of the Iceberg”

Clinical Neuroscience Grand Rounds, National Institutes of Health, Bethesda, MD (USA)

10/2017

3. Speaker: Luca Bartolini, MD. “Stiripentol for Dravet syndrome”

Clinical Neuroscience Grand Rounds, National Institutes of Health, Bethesda, MD (USA)

2/2018

4. Speaker: Luca Bartolini, MD. “HHV6 and EBV DNA Detection and Increased Cytokine Levels in Saliva from Children with Seizures”

Clinical Neuroscience Grand Rounds, National Institutes of Health, Bethesda, MD (USA)

3/2018

5. Speaker: Luca Bartolini, MD. “Hemophagocytic Lymphohistiocytosis (HLH) in Febrile Infection-Related Epilepsy Syndrome (FIRES)”

Clinical Neuroscience Grand Rounds, National Institutes of Health, Bethesda, MD (USA)

9/2018

6. Speaker: Luca Bartolini, MD. “Differential Activation of Neuroinflammatory Pathways in Children with Seizures”

Neurology Grand Rounds, Children’s National Hospital, Washington DC (USA)

5/2019

7. Speaker: Luca Bartolini, MD. “Three Classic Cases Of Seizures in Children: Febrile Seizures, Childhood Absence Epilepsy And Temporal Lobe Epilepsy”; “Migraine Headache In Children: When And How To Treat”

Colby/Brown Pediatrics Course, Colby College, Waterville, ME (USA)

7/2020 (postponed due to COVID19)

REGIONAL (North-East USA)

1. Speaker: Luca Bartolini, MD

Concept to Startup course (Neur1930J), Brown University School of Engineering

3/2020 (virtual due to COVID19)

2. Speaker: Luca Bartolini, MD “Pharmaco-resistant Epilepsy: “What are the Options when Medical Therapy is Not Enough to Control Seizures”

Pediatric Grand Rounds, Hasbro Children’s Hospital

3/2020 (virtual due to COVID19)

3. Speaker: Luca Bartolini, MD “Differential Gene Expression Analysis of RNA-Sequencing Data in Rasmussen Encephalitis”

4^th Annual Celebration of Pediatric Scholarship, Brown University.

10/2020 (virtual due to COVID19)

4. Speaker: Luca Bartolini, MD. Differential Gene Expression Analysis of RNA-Sequencing Data In Rasmussen Encephalitis. Yale University Monday Afternoon Coffee Seminars in Epilepsy Research (MACSIE). 1/25/21 (virtual due to COVID19)
5. Speaker: Luca Bartolini, MD. “Immune-Mediated Epilepsies: A Hard Nut To Crack”. Yale University Pediatric Neurology update. 2/8/2021 (virtual due to COVID19)
6. Speaker: Luca Bartolini, MD “Pharmacoresistant Epilepsy in Children: Why Early Diagnosis and Appropriate Treatment Should Be Our Priority”

University of Rhode Island (URI) Collaborative Office Rounds

3/2021 (virtual due to COVID19)

7. Speakers: Luca Bartolini, MD, Brian Kavanaugh, PsyD “Epilepsy and Neurocognitive Function in Patients with Neurogenetic Disorders”

Brown University Translational Research Seminar

4/2021 (virtual due to COVID19)

8. Speaker: Luca Bartolini, MD “Pediatric Epilepsy: Novel Treatment Strategies and Precision Medicine”

RI Epilepsy Conference

4/9/2022 (via Zoom)

9. Speaker: Luca Bartolini, MD “Anatomy of a Scientific Journal: Everything You Need to Know Before You Click Submit”.

WMC Trainee Research Summer Lecture Series, Brown University.

7/28/2022 (virtual)

1. Speaker: Luca Bartolini, MD “Treatment of Neonatal Seizures: Updates and Challenges”.

Neonatal Grand Rounds, Women & Infants Hospital, Providence, RI.

9/14/2022 (virtual)

1. Speaker: Luca Bartolini, MD “Analysis Of Differentially Expressed Genes By RNA-Sequencing In 39 Cases of Rasmussen Encephalitis: New Insights on Inflammatory and Non-Inflammatory Pathways”.

Pediatric Research Seminar, Department of Pediatrics, Hasbro Children’s Hospital, Women & Infants Hospital, Providence, RI.

5/9/2023

GRANTS:

Completed:

Socrates-Erasmus Exchange Medical School Scholarship

University Joseph Fourier, Grenoble (France)

09/2003 – 03/2004

American Epilepsy Society / Epilepsy Foundation of America

Research and Training Fellowship for Clinicians

“Research study on viral and inflammatory causes of epilepsy”.       

Role: PI

7/1/2017 – 6/30/2018

$50,000

Advance Clinical and Translational Research / Brown University IDeA grant (NIH U54GM115677)

“Epilepsy and Neurocognitive Function in Patients with Neurogenetic Disorders”

Role: Co-PI

5/1/2020 – 7/31/2022

$104,580

Children’s Miracle Network Annual Scholar Award

“Transcriptomics Analysis of Brain Specimens from Children with Rasmussen

Encephalitis”

Role: PI

10/1/2021 – 9/30/2022

$25,000

NIH/ NINDS RO1 NS104428-01

“The Circadian Molecular Clock in Pediatric Refractory Focal Epilepsy.”                 

Role: Co-I (PI Dr. Judy Liu)

2/01/2019-1/31/2023

OTHER RESEARCH ACTIVITY:

Hasbro Children’s Hospital Site Principal Investigator / Representative

Member of the Pediatric Epilepsy Surgery and Infantile Spasms SIG

Pediatric Epilepsy Research Consortium (PERC)

May 2021 – June 2023

Principal Investigator (PI)

“Analysis of anti-seizure medication side-effects leading to discontinuation of therapy in pediatric epilepsy”

November 2020 – July 2022

(Manuscript published)

Co-Investigator (Co-I)

“Natural history of ASH1L associated autism and neural cellular studies” (PI Dr. Judy Liu)

December 2020 – June 2023

Co-Investigator (Co-I)

“Electroencephalographic, genetic characteristics and treatment response in pediatric epilepsy associated with autism spectrum disorders” (PI Dr. Duyu Nie)

March 2021 – June 2023

(Manuscript in press)

Co-Investigator (Co-I)

“Anxiety as a predictor of family burden, functional impairment, and quality of life in pediatric patients with epilepsy” (PI Dr. Christine Trask)

September 2020 – June 2023

HOSPITAL TEACHING, ADVISING and MENTORING ROLES:

1. Supervisor and research mentor of Mr. Michael P. Moran, Post-baccalaureate Intramural Research Training Awardee (IRTA) at the National Institute of Neurological Disorders and Stroke / National Institutes of Health

09/2017 – 05/2019

2. Research advisor of Mr. Samer Wahood, Sc.B. Candidate – Computational Biology. Brown University.

7/2019 – 9/2019

3. Career advisor of Ms. Tatiana Abrantes, Medical Student. Brown University.
4. Career advisor of Ms. Tess Gabert, Medical Student. Brown University
5. Supervisor and research mentor of Ms. Julia Bassell, Medical Student. Brown University

10/2020 – 4/2021

6. Supervisor and research mentor of Ms. Karen Lob, Medical Student. Brown University

3/2021 – 6/30/2023 

Dr. Bartolini has a track record of funded highly competitive research grants as Principal Investigator (PI) and Co-Principal Investigator (Co-PI) in the United States.

During his career as a clinician-scientist, Dr. Bartolini has been involved in several clinical and translational research projects regarding epilepsy, ranging from studying viral and inflammatory mechanisms involved in the pathophysiology of epilepsy to imaging characteristics of drug-resistant pediatric epilepsy and to inflammatory mechanisms involved in super-refractory status epilepticus in children. More recently, Dr. Bartolini’s research focus has been to analyze neurophysiological features of rare genetic epilepsies, and decoding gene expression in surgically resected brain specimens from children affected by Rasmussen Encephalitis, a rare and devastating form of drug-resistant epilepsy.

Dr. Bartolini’s overarching research goal is to elucidate disease mechanisms involved in the development of drug-resistant epilepsy in children, with the aim of translating these discoveries into clinical practice as potential targets for novel therapeutic approaches and ultimately to improve the quality of life of children affected by this severe condition and their families.