CURRICULUM VITAE
NOME: Lucio LuzzattoDATA DI NASCITA: 28 Settembre 1936LUOGO DI NASCITA: Genova, ItaliaNAZIONALITÀ: ItalianaPOSIZIONE ATTUALE Professore Onorario di Ematologia, Università degli Studi di Firenze Abilitazione all’esercizio Italia 1960della professione medica Nigeria 1964 Regno Unito 1974 New York, Stati Uniti 1995 Tanzania 2016 Specializzazioni: Ematologia 1962 Fellow of the Royal College of Pathologists 1982 Fellow of the Royal College of Physicians 1983SCOLARITÀ E FORMAZIONE:Maturità Classica, Liceo D'Oria, Genova, 1953Laurea in Medicina e Chirurgia, Facoltà di Medicina e Chirurgia, Università degli Studi di Genova, Italia, 1959Libera Docenza in Biochimica, Ministero della Pubblica Istruzione, 1968Formazione post laureaBorsista Cassa di Risparmio di Genova, Istituto di Biochimica, Università degli Studi di Genova, 1959Assistente volontario, Istituto di Biochimica, Università degli Studi di Genova, 1960-71Assistente volontario, Divisione di Malattie Infettive, Ospedale S. Martino, Genova, 1960-62Fellow in Haematology, Department of Medicine, College of Physicians & Surgeons, Columbia Presbyterian Hospital, New York, 1963-64Lecturer in Haematology, responsabile Blood Transfusion Unit, Department of Pathology, University of Ibadan, Ibadan, Nigeria, 1964-67POSIZIONI PRECEDENTI1967-1968. Senior Lecturer, responsabile Sub-Department of Haematology, University of Ibadan, Ibadan, Nigeria e Consultant Haematologist, UCH, Ibadan, Nigeria.1968-74. Professore di Ematologia (dal 1970 Direttore del Dipartimento) University of Ibadan, Ibadan, Nigeria, 1968-74.1974-1981. Direttore, Istituto Internazionale di Genetica e Biofisica CNR, Napoli.1981-1994. Professore di Ematologia (University of London) e Direttore, Department of Haematology, Royal Postgraduate Medical School, London; Consultant Haematologist, Hammersmith Hospital, London, UK.1987-93. Direttore Onorario, Medical Research Council/Leukemia Research Fund, Leukemia Unit. 1994-2000. Direttore, Department of Human Genetics, Cattedra Courtney Steel, Attending Physician in Genetics and Haematology, Membro del Cell Biology and Genetics Programme, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center; Professore di Medicina e Genetica Umana, Cornell University Medical College, New York, USA.2000-2004. Direttore Scientifico, Istituto Nazionale per la ricerca sul cancro Genova.2002-2006. Professore Ordinario di Ematologia, Università degli Studi di Genova. 2005-2015. Direttore Scientifico, Istituto Toscano Tumori.2006-2008. Professore Ordinario di Ematologia, Università degli Studi di Firenze.2015-2022. Professore di Ematologia, Muhimbili University of Health and Allied Sciences (MUHAS), Dar-es-Salaam, Tanzania
LAUREE AD HONOREMLaurea ad honorem in Farmacia, Università degli Studi di Urbino, 1990Dottorato in Scienze (DSc.) ad honorem, University of Ibadan, Nigeria, 1998Eletto Foreign Member della American Academy of Arts and Sciences, 2004Laurea ad honorem in Medicina, Università degli Studi di Patras, Grecia, 2006
SOCIETÀ MEDICO-SCIENTIFICHEInternational Society of Haematology;Presidente, University College Hospital, Ibadan, Medical Society, 1968-70Socio fondatore e primo Presidente eletto, Nigerian Society for Haematology and Blood Transfusion, 1972-74: attualmente membro onorario Membro, Expert Panel on Abnormal Haemoglobins and Thalassemia International Committee on Standardization in Haematology, 1972-81Associazione Italiana di Genetica (Presidente), 1979-81Membro, Consiglio Direttivo, Società Italiana di Ematologia, 1977-80Membro, European Molecular Biology Organization (EMBO)Membro onorario, American Society of HaematologyMembro, Human Genome Organization (HUGO)Membro, American Association of PhysiciansPresidente, Ethics Committee, American Society for Gene Therapy, 1998-2000Foreign Member, Accademia dei Lincei, 2022
INCARICHI TEMPORANEI E CONFERENZE DEDICATEVisiting Scientist per un mese, Department of Human Genetics, University of Leiden, NL, 1966Visiting Scientist per sette mesi, Department of Microbiology, Washington University Medical School, St. Louis, MO, USA, 1967Visiting Professor per un mese, Department of Medicine, Makerere University, Kampala, Uganda, 1969Visiting Professor per due settimane, Department di Haematology, Mahidol University, Bangkok, Thailandia, 1972Visiting Professor per due settimane, Faculty of Medicine, University of Nigeria, Enugu, Nigeria, 1974"Henry M. Stratton Lecture", XV International Congress of Haematology, 1974Visiting Professor "Carl Harford", Washington University Medical School, St. Louis, MO, USA, 1983British Exchange Professor, Department of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA, 1987"Ham-Wasserman Lecture", American Society of Haematology, S. Francisco, CA, USA, 1988"Oliver-Sharpey Lecture", Royal College of Physicians, 1988Visiting Professor, Department of Medicine, University of Michigan, Ann Arbor, MI, USA, 1989"Adolfo Ferrata Lecture", Società Italiana di Ematologia, Roma, 1989Visiting Professor, Toronto General Hospital, Toronto, Canada, 1990Visiting Professor, Università degli Studi di Modena, Modena, 1991Visiting Professor, Università degli Studi di Napoli, Napoli, 1992Visiting Professor, Department of Pathology, University of Alberta, Edmonton, Alberta, Canada, 1994"Fifth William C. Maloney Lecture", Brigham and Women's Hospital, Boston, MA, USA, 1998"Lilly Lectures", Royal College of Physicians, London and Sheffield, UK, 1999José Carreras Lecture, European Haematology Association, Firenze, 2002 Lettura Sandro Vaciago, Piacenza, 2003Lettura Chiara D'Onofrio, Roma, 2004Lettura magistrale al Congresso Brasileiro de Hematologia e Hemoterapia, Recife, 2006PREMI E RICONOSCIMENTIPremio Livierato, Università degli Studi di Genova, 1957Premio Pasetto, Università degli Studi di Genova, 1958Premio Istituto Nazionale Assistenza Infortuni sul Lavoro, 1960Borsa di studio del Ministero della Pubblica Istruzione, 1962Fulbright Senior Fellow, 1967Medaglia Pio XI, 1976Premio Internazionale Sanremo per la Genetica Umana, 1982Premio Internazionale Chirone per la Ricerca Biomedica, 1995Premio Napoli, 1995Nigerian Society of Haematology and Blood Transfusion: 25th Year Jubilee Lecture, 1997Premio Pier Camillo Beccaria, Associazione Angela Serra, Modena, 1999Premio Liguria, 2000James Blundell Award, British Society of Blood Transfusion, 2001Premio José Carreras, European Haematology Association, Firenze, 2002 Premio Novaro, Genova, 2005Medaglia Giuseppe Montalenti, Roma, 2006 Targa Piazzi, Palermo, 2006Premio Giovanni Maria Pace per il miglior saggio italiano di divulgazione scientifica, Trieste, 2007ALTRI INCARICHI, NOMINE, ATTIVITÀDirettore, WHO Regional Reference Centre (Africa) for glucose-6-phosphate dehydrogenase, 1967-74Direttore, WHO Collaborative Centre for human glucose-6-phosphate dehydrogenase, Napoli, 1976-81Membro (Presidente dal 1983), Steering Committee of Scientific Working Group on Biomedical Sciences, Special Programme on Tropical Diseases, WHO, 1978-1986.Membro, Medical Research Council (MRC) Cell Board Grants Committee, 1982-86Membro, Clinical Panel of Wellcome Trust, 1986-88Human Genome Mapping Grants Committee, 1989-91Membro, Pathology Panel of Universities Funding Committee, 1992Nomina a componente Scientific Group for the standardization of techniques for the study of glucose-6-phosphate dehydrogenase, WHO, 1996Presidente, Comitato Scientifico Fondazione Giambrone per la lotta alla talassemia, 1997-2000Membro, International Outreach Ad Hoc Committee, American Society of Haematology, 1999 Membro, Commissione Oncologica Nazionale, Ministero della Sanità, 2000-Membro, Commissione per lo studio sulle cellule staminali, Ministero della Sanità, 2000 Membro, Comitato Scientifico Fondazione Pezcoller, 2001-2004Rappresentante del Ministro della Salute nel Programma di Ricerca Nazionale del Governo Italiano, 2002Membro, International Agency for Research on Cancer Fellowship Committee, 2002-2005Membro, External Advisory Board, Weatherall Institute of Molecular Medicine, Oxford, 2002Membro, Comitato Scientifico, Associazione volontaria Cristina Bassi onlus, Genova, 2003Membro, Scientific Advisory Board, Canceropole, Lyon, 2004Membro, National Research Review Committee, NHS Blood and Transplant, London, 2005-2010Membro, Scientific Advisory Board, Clinigene, 2005-2010Membro, Comitato di Consulenza Scientifica, (Presidente dal 2008) Fondazione per la Ricerca sulla Fibrosi Cistica, Verona, 2006-2015
CONOSCENZE LINGUISTICHEForma parlata: Italiano, Inglese, Francese, TedescoForma scritta: Italiano, Inglese
STATO CIVILE ConiugatoNome del coniuge: Paola Caboara LuzzattoFigli: Stefano e FatimaObblighi Militari: Ufficiale Medico, Esercito Italiano, 1960-61Attualmente Ufficiale Medico in congedo illimitato
Autore di 455 pubblicazioni scientifiche elencate in PubMedAutore del libro CAPIRE IL CANCRO, Rizzoli, 2006; BUR 2009.
Lucio Luzzatto -INTERESSI
Lucio Luzzatto ha rivolto continuamente la ricerca e l’insegnamento alla medicina molecolare: vale a dire, a comprendere le malattie umane a livello molecolare, particolarmente nell’ambito delle malattie ematologiche: con il fine ultimo di migliorare la terapia. • LL con i suoi collaboratori, negli anni ottanta, ha realizzato il clonaggio del gene della G6PD, ponendo così le fondamenta per la fisiopatologia molecolare e molti studi popolazionistici della enzimopenia G6PD. Da allora ha continuato a studiare la genetica e la biochimica delle varianti della G6PD, le relative implicazioni cliniche, e le correlazioni genotipo-fenotipo. La sua prima pubblicazione sulla G6PD risale al 1961, l’ultima è del 2024.• Nel settore della malaria, LL e collaboratori hanno dimostrato per primi che la protezione contro la malaria grave è prerogativa delle eterozigoti per enzimopenia G6PD. Inoltre, sono stati compiuti studi sui meccanismi attraverso i quali sia questa enzimopenia, sia la eterozigosi per enoglbina S proteggono dalla mortalità malarica. • Nel settore delle leucemie e linfomi il gruppo di LL è stato tra i primi a studiare i riarrangiamenti dei geni delle immunoglobuline e dei recettori delle cellule T nella diagnosi e nel monitoraggio dei pazienti con queste malattie.• LL ha studiato il tasso delle mutazioni somatiche nella specie umana ed il loro ruolo in malattie.• LL ha svolto ricerca sperimentale sul trasferimento genico avente come fine ultimo la terapia genica, ed ha partecipato alla prima terapia genica efficace della talassemia in un modello murino. • LL e collaboratori hanno per primi dimostrato che l’emoglobinuria parossistica notturna (EPN) è una malattia clonale dell’ematopoiesi. LL ha poi introdotto il concetto di selezione clonale condizionale, oggi ampiamente accettata come patogenesi della malattia. Tale concetto è molto pertinente ai rapporti tra EPN ed anemia aplastica, ed alle attuali terapie dell’EPN. La prima pubblicazione di LL sulla EPN risale al 1970, l’ultima è del 2025.
Legenda
CURRICULUM VITAE - 2025NAME Lucio LuzzattoDATE/PLACE OF BIRTH September 28, 1936; Genova, ItalyNATIONALITY Italian MARITAL STATUS Married with Paola Caboara Luzzatto; children Stefano & Fatimae-mail: <lucio.luzzatto@unifi.it>PRESENT POSITION Honorary Professor, University of Florence, Firenze, ITALY MEDICAL LICENCE 1960 Italy 1965 Nigeria 1981 United Kingdom 1995 New York State2016 Tanzania BOARDS 1962 Hematology 1982 FRCPath 1983 FRCPEDUCATION1953 Maturità Classica, Liceo D'Oria, Genova, Italy, 1959 University of Genova Medical School M.D., Genova, Italy, 1968 Libera Docenza (PhD) in Biochemistry, Ministry of Education, Italy, POSTGRADUATE CLINICAL AND RESEARCH TRAINING1959-62 Resident, Department of Infectious Diseases, Ospedale S. Martino, Genova;Research Fellow (part-time), Department of Biochemistry (2 years), then Department of Biophysics (1 year), University of Genova, Genova, Italy1963-64 Fellow in Haematology, Department of Medicine, College of Physicians & Surgeons, Columbia Presbyterian Hospital, New York, NY, USA.1964-67 Lecturer in Haematology, in charge of Blood Transfusion Unit Department of Pathology, University of Ibadan, Ibadan, Nigeria.POSITIONS AND APPOINTMENTS1967-68 Senior Lecturer in charge of Sub-Department of Haematology, University of Ibadan, Ibadan, Nigeria; Consultant Haematologist, UCH, Ibadan, Nigeria, 1968-1974 Professor of Haematology (from 1970 Head of Department) University of Ibadan, Ibadan, Nigeria. 1974-1981 Director, International Institute of Genetics and Biophysics, CNR, Napoli, Italy, 1981-1994 Professor of Haematology (University of London), and Director of Haematology Department, Royal Postgraduate Medical School (now Imperial College), London; Consultant Haematologist, Hammersmith Hospital, 1994-2000 Chairman, Department of Human Genetics, Courtney Steel Chair, Attending Physician in Genetics and Hematology, Memorial Sloan-Kettering Cancer Center; Member of the Cell Biology and Genetics Programme, Sloan-Kettering Institute, Professor of Medicine and Human Genetics, Cornell-Weill University Medical College, New York, NY, USA. 2000-2004 Scientific Director, National Institute for Cancer Research, Genova, Italy, 2002-2006 Professor of Haematology, DOBIG, University of Genova, Genova, Italy 2005-2015 Scientific Director, Istituto Toscano Tumori, Florence, Italy2015-2022 Professor of Haematology, Muhimbili University College of Health and Allied Sciences (MUHAS), Dar-es-Salaam, Tanzania.2006- Professor of Haematology (Honorary since 2008), University of Florence, , Italy.HONORARY DEGREES • Laurea ad honorem in Pharmacy, University of Urbino, Italy, 1990• DSc, University of Ibadan, Nigeria, 1998• Laurea ad honorem in Medicine, University of Patras, 2006.
HONORS/AWARDS (PARTIAL LIST)• Pius XI Medal, 1976• Sanremo International Prize for Human Genetics, 1982• Ham-Wasserman Lecture, American Society of Haematology, San Francisco, CA, USA, 1988• Oliver-Sharpey Lecture, Royal College of Physicians, 1988 • Adolfo Ferrata Lecture, Italian Society of Haematology, Rome, Italy, 1989 • Premio Napoli, 1995• Nigerian Society of Haematology and Blood Transfusion: 25thYear Jubilee Lecture, 1997• Fifth William C. Maloney Lecture, Brigham and Women's Hospital, Boston, MA, 1998• Lilly Lectures - Royal College of Physicians, London and Sheffield, UK, 1999 • Premio Pier Camillo Beccaria, Associazione Angela Serra, Modena, Italy, 1999• Premio Liguria, 2000 • James Blundell Award, British Society of Blood Transfusion, 2001• Josè Carreras Lecture - European Haematology Association, Firenze, 2002 • Foreign Member, American Academy of Arts and Sciences, 2004.• Montalenti Medal, University of Rome, 2007.• Premio Giovanni Maria Pace, Trieste, 2007. • Scientific Prize Accademia delle Scienze of Torino, 2011.• Serafino Zappacosta Memorial Lecture, Napoli, 2012.• Address to International Leaders in Haematology, ASH, Orlando, FL, USA, 2015 • Accademia dei Lincei Annual Scientific Prize for Biology, 2015.• Environmental Mutagenesis and Genomics Society PIG-A Award, 2016OTHER (PARTIAL LIST) • Director, WHO Regional Reference Centre (Africa) for glucose-6-phosphate dehydrogenase: Ibadan 1967-74; Naples, 1976-1981• Member (Chairman from 1983) of Steering Committee of Scientific Working Group on Biomedical Sciences, Special Programme on Tropical Diseases, WHO, 1978-86• Member National Cancer Advisory Board - Ministry of Health, Italy, 2000• Member National Advisory Board on Stem Cell Research - Ministry of Health, Italy, 2000• Member of Scientific Committee, Science Festival, Genova, 2003-2012• Member of Life Sciences Panel 7, European Research Council, Bruxelles, 2008-2016• Chair, Scientific Advisory Committee, Italian Cystic Fibrosis Foundation, 2012-2015• Chair, Scientific Advisory Committee, Josep Carreras Institute, Barcelona, 2013-2023• Chair, WHO Evidence Review Group on Point of Care G6PD Testing to Support Safe Use of Primaquine for the Treatment of Vivax Malaria, Geneva, 2014• Co-chair and organizer of “Advances in Haematology in Africa”, Dar-es-Salaam, Tanzania, 2018• Member, WHO Technical Consultation on G6PD, 2022• Member of Global Award Sub-Committee, American Society of Hematology, 2018-2020.• Foreign Member, Accademia Nazionale dei Lincei, 2022.
The leitmotiv of Lucio Luzzatto’s research and teaching has been the understanding of human disease at the molecular level; particularly in the area of blood diseases, for the ultimate purpose to improve their management. LL and colleagues cloned the human G6PD gene in the early eighties, thus laying foundations for the molecular pathophysiology and population genetics of G6PD and G6PD deficiency. In the area of malaria, beyond pioneering the work that indicated that heterozygotes for G6PD deficiency are protected against mortality for P falciparum, LL has opened insights on the mechanism of malaria selection with respect to both the sickle cell trait and G6PD deficiency. LL first provided evidence that paroxysmal nocturnal haemoglobinuria (PNH) is a clonal disorder, introduced the concept of conditional clonal selection and provided supporting evidence: thus rationalising the relationship of clonal expansion with bone marrow failure, and with the treatment of PNH. In summary, LL has devoted his research to contemporary molecular medicine.
PUBLICATIONS455 scientific papers listed in PubMed. Many chapters in major textbooks. 1 Book for lay people: CAPIRE IL CANCRO (UNDERSTANDING CANCER), Publ. Rizzoli, 2006; Paperback edition (BUR), 2009.
Lucio Luzzatto has devoted his research and teaching to contemporary molecular medicine: i.e. in the understanding of human disease at the molecular level; particularly in the area of blood diseases, for the ultimate purpose to improve their management. • LL and colleagues cloned the human G6PD gene in the early eighties, thus laying foundations for the molecular pathophysiology and population genetics of G6PD and G6PD deficiency. Since that time, LL has continued to investigate the biochemical genetics of G6PD deficiency, its clinical implications, and genotype-phenotype correlations. The first paper on G6PD was published in 1961, the last in 2024. • In the area of malaria, beyond pioneering the work that indicated that heterozygotes for G6PD deficiency are protected against mortality for P falciparum, LL has opened insights on the mechanism of malaria selection with respect to both the sickle cell trait and G6PD deficiency. • In the area of leukaemia and lymphoma, LL has been among the first to study immunoglobulin gene rearrangements and T cell receptor gene rearrangements in the diagnosis and in the follow-up of these disorders. • LL has investigated the rate of somatic mutations and their role in human disease• LL has carried out research in gene transfer for the ultimate goal of gene therapy, and has taken part in the first successful gene therapy of thalassemia in a mouse model. • LL first provided evidence that paroxysmal nocturnal haemoglobinuria (PNH) is a clonal disorder, introduced the concept of conditional clonal selection and provided supporting evidence: thus rationalising the relationship of clonal expansion with bone marrow failure, and with the treatment of PNH. The first paper on PNH was published in 1970, the last in 2025.
