ISTRUZIONE E FORMAZIONE
Giugno 2016-giugno 2019
Senior Honorary Clinical Research Fellow", posizione full staff, presso la Clinical Epidemiology Unit, Musculosketal Research program presso l'Università di Aberdeen, King's College, Aberdeen, Scozia, Regno Unito, Direttore, Prof. Gary Macfarlane, da 06/2016 a 06/2019
Gennaio 2012-dicembre 2015 Clinical Research Fellow, posizione full staff, presso la Clinical Epidemiology Unit, Division of Applied Health Sciences, Università di Aberdeen, King's College, Aberdeen, Scozia, Regno Unito
Marzo 2011 medico ospite presso la Clinical Epidemiology Unit, Musculosketal Research program presso l'Università di Aberdeen, King's College, Aberdeen, Scozia, Regno Unito
Marzo 2009 "partecipante selezionato" presso la Clinical Epidemiology Unit, presso l'Università di Aberdeen per "Intensive Course in Applied Epidemiology presso l'Università di Aberdeen, King's College, Aberdeen, Scozia, Regno Unito
Ottobre 2007 Specializzazione in Reumatologia presso l'Università di Firenze, con punteggio di 70/70 e lode
Gennaio 2004-giugno 2004 Clinical Fellow in Paediatric Rheumatology presso DuPont Children's Hospital-Wilmington (DE) - Department of Rheumatology, T. Jefferson University of Philadelphia (PA)-USA
Ottobre 2003 Specializzazione in pediatria generale e specialistica presso l'Università di Firenze, con punteggio di 70/70 e lode
Giugno 1995-giugno 1998 Tirocinio clinico in Pediatria presso il III Dipartimento di Clinica Pediatrica di Pediatria, Università di Firenze/Ospedale pediatrico Anna Meyer
Gennaio 1995-dicembre 1998 Tirocinio clinico e di ricerca in Reumatologia presso il Dipartimento di Medicina Interna-Sezione di Reumatologia, Università di Firenze,
Gennaio 1995-settembre 1997 Tirocinio clinico in Medicina Interna presso il IV Dipartimento di Medicina Interna, Università di Firenze
Ottobre 1997 Laurea in Medicina e Chirurgia 107/110 presso l'Università di Firenze
ESPERIENZA LAVORATIVA
Gennaio 2025- attuale
Esperto selezionato per la rete Connect 4 Children (c4C) in Etica, Reumatologia e Malattie autoimmuni, Progettazione dello studio e Metodologia della sperimentazione clinica
Ottobre 2023- attuale
Presidente della task force Pediatric ERN-ReCONNET per lo sviluppo di linee guida cliniche per la cura transitoria dei tessuti connettivi giovanili
Giugno 2019- attuale
Direttore presso l'Unità di Reumatologia - Centro ERN-ReCONNET, Meyer Children's Hospital IRCCS, Firenze Settembre
2016-attuale Professore associato in Pediatria presso il Dipartimento NEUOROFARBA, Università di Firenze Marzo
2020-attuale Docente senior, posizione onoraria, presso l'Unità di epidemiologia clinica, Divisione di scienze sanitarie applicate, - Università di Aberdeen, King's College, Aberdeen, Scozia, Regno Unito
Luglio 2016-luglio 2023 membro del Comitato Etico della Regione Toscana, Consiglio Pediatrico, in qualità di pediatra, esperto in metodologia della ricerca
Novembre 2001-Maggio 2019 Ricercatore/Medico di ruolo presso l'Unità di Reumatologia Pediatrica - Ospedale Pediatrico Meyer
Novembre 2001-Agosto 2016 Ricercatore presso il Dipartimento NEUROFARBA - Università di Firenze
Parametri Metrici della RICERCA
Web of Science ResearcherID: K-2647-2018 ORCID: 0000-0002-5919-4861
Publication Metrics prepared on Web of Science:
380 Web of Science Core Collection publications
5830 Sum of Times cited 4554 Citing articles
41 H-Index
Premi
Nel settembre 2001, all'VIII Congresso Europeo di Reumatologia Pediatrica, tenutosi a Utrecht, nei Paesi Bassi, ha ricevuto il premio per il miglior giovane ricercatore del 2001: Young Investigator Award della Paediatric Rheumatology European Society (PRES), per l'eccellenza nella ricerca
Esperienza in Ricerca & Clinical Trials Profit/Grants Internazionali
2021-2023 Predicting uveitis onset in children with juvenile idiopathic arthritis- Uveitis Study (PEDIA-U). CODE: R01 EY030521-0. Grant: National Eye Institute (32580 $). Role: European PI
2021-2024 Comparison and performance of Kobayashi and Kawanet IVIg resistance scores in a multi-centric European and North Indian cohort of Kawasaki disease - The KIWI study Code: N.A Grant: Pediatric Rheumatology European Society (30.000 €). Code: NCT06305611 Role: Supervisor
2021-2023 Baricitinib in juvenile idiopathic arthritis: an international, phase 3, randomised, double-blind, placebo-controlled, withdrawal, efficacy, and safety trial. Code: I4V-MC-JAHX Funding: Eli-Lilly Role: Site PI
2021-2022 A Phase 3 Multi-center, Open-Label Study of Abatacept Administered Subcutaneously (SC) in Children and Adolescents with Active Polyarticular Juvenile Idiopathic Arthritis. Code: I4V-MC-JAHW Funding: Bristol Myers Squibb Role: Site PI
2021-2024 Kawasaki Disease Coronary Artery Aneurysm Prevention trial study. KD-CAAP Code: 777389 Grant: Conect4children grant (18.000 €). Role: Site PI
2021-on going An Open-label, Active-Controlled Study of Baricitinib in Patients with Active Juvenile Idiopathic Arthritis-Associated Uveitis or Chronic Anterior Antinuclear Antibody-Positive Uveitis- JUVE-Bright. Code: I4V-MC-JAHW Funding: Eli-Lilly Role: Site PI 2021-on going Multicenter, Open-label, Study of Subcutaneous Ixekizumab with Adalimumab Reference Arm, in Children with Juvenile Idiopathic Arthritis Subtypes of Enthesitis-related Arthritis/ Juvenile Psoriatic Arthritis. Code: I1F-MC-RHCG Funding: Eli-Lilly Role: Site PI
2024-on going Open-label, randomized, assessor-blinded, efficacy, safety, tolerability, and pharmacokinetics study of subcutaneous risankizumab with an adalimumab reference arm in children with active juvenile psoriatic arthritis. Code: M23-732. Funding: Abbvie. Role: Site PI
2024-on going Open-label, randomized, assessor-blinded, efficacy, safety, tolerability, and pharmacokinetics study of Upadacitinib with Tocilizumab reference arm in children with active systemic juvenile idiopathic arthritis. Code: M14-6822. Funding: Abbvie. Role: Site PI
Profit/Grant Nazionali
2021-2023 Regional Survey to identify Kawasaki Diseases index cases versus Multisystem inflammatory syndrome in children (MIS-C) associated with SARS COV-2 infection. Code: COVASAKI. Grant: Tuscany COVID (199.387 €) Research Role: PI
2022-2024 Quality of life and care compliance in Juvenile Chronic Rheumatic Diseases: a comparative prospective study. Code: QoL-JCRD. Grant: Pistoia Cassa di Risparmio Research (80.000 €) Role: PI
2023- on going A randomized, two-armed, single-blind, parallel, active controlled, and non- inferiority clinical trial to Compare Efficacy and Safety of anti TNF-alfa biosimilar molecules to the originators in children with active Juvenile Idiopatic Arhtiriritis. Code: CEST-JIA Role: site PI
Registri
CHronic nonbacterial Osteomyelitis International Registry (CHOIR) Role: site PI A.I.D.A.
Development of an International Multicenter Registry of Patients with Monogenic and Polygenic Autoinflammatory Diseases aimed at clinical and therapeutical data collection and analysis. Role Site PI. Abatacept JIA registry.
Code: BMS-ABA Registry Funding: Bristol Myers Squibb Role: Site PI
EUROFEVER. The international registry for Auto-inflammatory diseases. Role: site PI The Hyper-PED COVID Registry. International Registry of the inflammatory condition in temporal association with the COVID-19. Role: site PI
Prospective Observational International Study on Childhood Chronic Non-infectious Uveitis (RChildUV). Code: NCT06273748 Grant: Roche (30.000 €) Role: PI
Childhood Chronic Connective Tissues Disease Registry- ERN-ReCONNET. Grant: EU4H-2023-ERN2-IBA (311.000 €) Role: PI Inceptions Cohort for Juvenile Systemic Sclerosis. Role: site PI LU.NE Registry.
The National registry of the neonatal Systemic Lupus. Role: site PI.
COVASAKI: Tuscany Registry for the Kawasaki Disease. Role: PI
Onorificenze
Ottobre 2021-2024 Consigliere della Società Italiana di Reumatologia Pediatrica
Giugno 2019-oggi Responsabile dell'Uveitis Working Group, iscritto alla Pediatric Rheumatology European Society
Settembre 2016-giugno 2019 Segretario dell'Uveitis Working Group, iscritto alla Pediatric Rheumatology European Society Febbraio 2011-oggi Membro fondatore del Multinational Interdisciplinary Working Group for Uveitis in Childhood dal 2011
Giugno 2002-settembre 2005 Trainee Representative della Paediatric Rheumatology European Society (PRES), e quindi membro del consiglio direttivo della stessa, fino a settembre 2005.
Autorizzo il trattamento dei miei dati personali ai sensi del D.Lgs. 196/2003 e dell'art. 13 del GDPR 679/16
PRINCIPALI INTERESSI DI RICERCA
Si sviluppa nell'ambito delle patologie infiammatorie croniche dell'età evolutiva. L'artrite idiopatica giovanile, la malattia di Kawasaki, le uveiti, le connettiviti pediatriche e le sindromi auto-infiammatorie sono le principali patologie verso cui sono principalmente orientati gli ambiti di ricerca.
Sono attive e costanti collaborazioni di ricerca con Paediatric Rheumatology International Trials Organisation (PRINTO) e con Childhood Arthritis and Rheumatology Research Alliance (CARRA).
Legenda
EDUCATION AND TRAINING
June 2016-June 2019
Senior Honorary Clinical Research Fellow”, full staff position, at the Clinical Epidemiology Unit, Musculosketal Research program at the University of Aberdeen, King's College, Aberdeen, Scotland, UK, Director, Prof . Gary Macfarlane, from 06/2016 to 06/2019
January 2012-December 2015
Clinical Research Fellow, full staff position, at the Clinical Epidemiology Unit, Division of Applied Health Sciences, University of Aberdeen, King's College, Aberdeen, Scotland, UK
March 2011
visiting physician at the Clinical Epidemiology Unit, Musculosketal Research program at the University of Aberdeen, King's College, Aberdeen, Scotland, UK March 2009 "selected attendee" at the Clinical Epidemiology Unit, at the University of Aberdeen for "Intensive Course in Applied Epidemiology at the University of Aberdeen, King's College, Aberdeen, Scotland, UK
October 2007 Graduated in Rheumatology at the University of Florence, with a score of 70/70 cum laude
January 2004-June 2004
Clinical Fellow in Paediatric Rheumatology at DuPont Children's Hospital-Wilmington (DE) - Department of Rheumatology, T. Jefferson University of Philadelphia (PA)-USA
October 2003
Graduated in general paediatrics and a specialist at the University of Florence, with a score of 70/70 cum laude
June 1995-June 1998
Clinical Training in Paediatrics at the Third Paediatric Clinic Department of Paediatrics, University of Florence/ Anna Meyers Children’s Hospital January
1995-December 1998
Clinical and Research Training in Rheumatology at the Internal Medicine Department-Rheumatology Section, University of Florence,
January 1995-September 1997
Clinical Training in Medical Intern, from January 1995 to September 1997 at the Fourth Internal Medicine Department, University of Florence October
1997 Graduated in Medicine and Surgery 107/110 from University of Florence
WORK EXPERIENCE
January 2025- current Selected expert for Connect 4 children (c4C) network in Ethics, Rheumatology & Auto-immune diseases, and Study design & Clinical Trial Methodology
October 2023- current Chair of the Pediatric ERN-ReCONNET Task force for developing Clinical Guideline for Transitional Care for juvenile Connective Tissues
June 2019- current Chief at the Rheumatology Unit- ERN-ReCONNET center, Meyer Children's Hospital IRCCS, Florence September
2016-current Associate Professor in Paediatrics at the NEUOROFARBA Department, University of Florence March
2020-current Senior Lecturer, Honorary position, at the Clinical Epidemiology Unit, Division of Applied Health Sciences, - University of Aberdeen, King's College, Aberdeen, Scotland, UK July
2016-July 2023 member of the Tuscany Ethical Commitee Paediatic Board, as pediatrician, expert in research methodology November 2001-May 2019 Assistant Professor/Staff Physician at the Paediatric Rheumatology Unit - Meyer Children’s Hospital November
2001-August 2016 Researcher at NEUROFARBA Department-University of Florence
Metric DATA
380 Web of Science Core Collection publications 5830 Sum of Times cited 4554 Citing articles 41 H-Index
Awards
In September 2001, at the VIII European Congress of Paediatric Rheumatology, held in Utrecht, Netherlands, he was the recipient of the award for best young researcher in 2001: Young Investigator Award of the Paediatric Rheumatology European Society (PRES), for excellence in research
Experience in Research & Clinical Trials Profit/Grant International
Profit/Grant National
Registries
Honors
October 2021-2024 Adviser of the Italian Society of Pediatric Rheumatolgy
June 2019-current Chief of the Uveitis Working Group, joined to the Pediatric Rheumatology European Society
September 2016-June 2019 Secretary of the Uveitis Working Group, joined to the Pediatric Rheumatology European Society
February 2011-current Founder member of the Multinational Interdisciplinary Working Group for Uveitis in Childhood since 2011
June 2002-September 2005 Trainee Representative of Paediatric Rheumatology European Society (PRES), and thus a member of the board of the same, until September 2005.
I authorize the processing of my personal data according to the Legislative Decree 196/2003 and art. 13 of GDPR 679/16
MAIN RESEARCH AIMs The research area encompasses the field of chronic inflammatory diseases in childhood. Juvenile idiopathic arthritis, Kawasaki disease, uveitis, pediatric connective tissue diseases and auto-inflammatory syndromes are the main diseases towards which the research areas are mainly oriented. There are active and constant research collaborations with Paediatric Rheumatology International Trials Organisation (PRINTO) and with Childhood Arthritis and Rheumatology Research Alliance (CARRA).
