Rosanna MATUCCI

Ruolo attuale:: Ricercatore in Pensione
SSD:: BIO/14 - Farmacologia
Afferenza organizzativa:: Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino (NEUROFARBA)

Recapiti

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	rosanna.matucci(AT)unifi.it

Ulteriori Recapiti

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Rosanna MATUCCI

Orario di ricevimento (aggiornato al 13/10/2011) Tutti giorni, previo appuntamento

Rosanna MATUCCI

Biografia

Laureata in Chimica e Tecnologie Farmaceutiche presso l’Università degli Studi di Firenze col massimo dei voti e lode

Ricercatore presso il Dipartimento di NEUROFARBA, Università degli Studi di Firenze 2004-2022;

In pensione dal 1 novembre 2022

Rosanna MATUCCI

Curriculum

STUDI: 1974-1980 Laurea in Chimica e Tecnologia Farmaceutiche, Università degli Studi di Firenze

ESPERIENZE PROFESSIONALI:

settembre 1980-marzo1981: Tirocinio pratico per l'ammissione all'esame di stato per l'abilitazione all'esercizio della professione di Farmacista.

1981: Abilitazione all'esercizio della professione di Farmacista

1983-1989: Assegno di formazione professionale del CNR, Dipartimento di Farmacologia di Firenze.

1980-2000: Frequenta corsi di specializzazione e scuole di carattere nazionale e internazionale

1990-2001: Funzionario tecnico, Dipartimento di Farmacologia di Firenze Novembre 2001-2004: Ricercatore confermato per la Facoltà di Medicina e Chirurgia dell'Università di Firenze, Dipartimento NEUROFARBA

2004-2022: Ricercatore confermato per la Facoltà di Farmacia dell'Università di Firenze, Dipartimento NEUROFARBA

2006-2022: Professore aggregato per la facoltà di Farmacia

dal 1 novembre 2022 ricercatore in pensione

INCARICHI DIDATTICI:

Docente del corso integrato di Farmacotossicologia e Galenica Farmaceutica per il Corso di Laurea in Tecniche di Laboratorio Biomedico (2000-2004)

Incarico di supplenza del corso integrato di Farmacotossicologia e Galenica Farmaceutica per il Corso di Laurea in Tecniche di Laboratorio Biomedico (2005-2012)

Titolare del corso di Farmacologia Generale per il Corso di laurea in Farmacia (2010-2014)

Titolare del corso di Farmacologia Generale e di Saggi Farmacologici per il Corso di Laurea in Scienze Farmaceutiche Applicate (2004-2022)

Delegato di Orientamento e Tutorato Membro della Commissione Didattica Membro della Commissione Coordinamento Corsi

Attività didattica nelle Scuola di Specializzazione in Farmacia Ospedaliera

Attività didattica nella Scuola di Dottorato di Ricerca in Farmacologia

ALTRI TITOLI Membro del comitato organizzatore del congresso "Sulfur amino acids, peptides and related compound" (San Miniato, Firenze, October 6-9, 1986) Membro della Società Italiana di Farmacologia

REVIEWER:

Cardiovascular Research Pharmacological Research

British Journal of Pharmacology

Rosanna MATUCCI

Interessi

INTERESSI DI RICERCA:
Meccanismi cellulari delle aritmie cardiache; Farmaci antiaritmici
- danno provocato da modelli di ipossia e ipossia più riossigenzione a livello cardiaco in animali da esperimento e coinvolgimento dei radicali liberi dellossigeno: studi di binding delle diidropiridine
- specie radicaliche coinvolte nel danno provocato dalla riperfusione che segue un periodo di ischemia in modelli umani (cuori espiantati): effetto dei calcio antagonisti sui radicali studiato con tecniche di risonanza elettronica di spin (EPR)
-meccanismo di azione del neuropeptide Y (NPY) nell attivazione GTPasica a livello nel ventricolo di ratto: evidenze per una stimolazione diretta delle Gi protein
-studi di binding per i recettori beta adrenergici in miociti cardiaci umani e di ratto in patologie cardiovascolari.
-collaborazione con centri di ricerca per lo studio dei recettori muscarinici in tessuti animali e in linee cellulari che esprimono stabilmente i recettori muscarinici umani (m1-m5) WT e mutati, meccanismi allosterici

-collaborazioni con centri dimricerca per lo studio di recettori beta adrenergici in linee cellulari che esprimono stabilmente i tre sottotipi recettoriali umani (WT e mutati), studi sui decondi messaggeri

Rosanna MATUCCI

Pubblicazioni

Legenda

Contributo su rivista |

Articolo su libro |

Libro |

Contributo in atti di convegno (proceeding) |

Brevetto |

Curatela | Altro

Altro |

Tesi di Dottorato

Artasensi, Angelica; Angeli, Andrea; Lammi, Carmen; Bollati, Carlotta; Gervasoni, Silvia; Baron, Giovanna; Matucci, Rosanna; Supuran, Claudiu T; Vistoli, Giulio; Fumagalli, Laura (2022). Discovery of a Potent and Highly Selective Dipeptidyl Peptidase IV and Carbonic Anhydrase Inhibitor as "Antidiabesity" Agents Based on Repurposing and Morphing of WB-4101. JOURNAL OF MEDICINAL CHEMISTRY, vol. 65, pp. 0-0, ISSN:0022-2623 DOI

Hamurtekin, E; Hamurtekin, Y; Matucci, R; Dei, Silvia; Baris, E; Kazdagli, H (2022). Cholinergic Receptor Binding Profile of Hypericum perforatum L. and its Active Constituents. INTERNATIONAL JOURNAL OF PHARMACOLOGY, vol. 18, pp. 1429-1439, ISSN:1811-7775 DOI

Fabio Del Bello, Alessandro Bonifazi, Gianfabio Giorgioni, Alessandro Piergentili, Maria Giovanna Sabbieti, Dimitrios Agas, Marzia Dell’Aera, Rosanna Matucci, Marcin Górecki, Gennaro Pescitelli, Giulio Vistoli, Wilma Quaglia (2020). Novel Potent Muscarinic Receptor Antagonists: Investigation on the Nature of Lipophilic Substituents in the 5- And/or 6-Positions of the 1,4-Dioxane Nucleus. JOURNAL OF MEDICINAL CHEMISTRY, vol. ..............................., pp. 1-20, ISSN:0022-2623 Accesso ONLINE all'editore

Mazzolari A.; Gervasoni S.; Pedretti A.; Fumagalli L.; Matucci R.; Vistoli G. (2020). Repositioning dequalinium as potent muscarinic allosteric ligand by combining virtual screening campaigns and experimental binding assays. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, pp. 1-17, ISSN:1661-6596 DOI

Matucci R.; Bellucci C.; Martino M.V.; Nesi M.; Manetti D.; Welzel J.; Bartz U.; Holze J.; Trankle C.; Mohr K.; Mazzolari A.; Vistoli G.; Dei S.; Teodori E.; Romanelli M.N. (2020). Carbachol dimers with primary carbamate groups as homobivalent modulators of muscarinic receptors. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 883, pp. 1-9, ISSN:0014-2999 DOI

Di Capua A, Reale A, Paolino M, Chemi G, Brogi S, Cappelli A, Giorgi G, Grande F, Di Cesare Mannelli L, Ghelardini C, Matucci R, Garofalo A, Anzini M. (2020). Design, synthesis and biological evaluation of 7-substituted 4-phenyl-6H-imidazo[1,5-a]thieno[3,2-f] [1,4]diazepines as safe anxiolytic agents.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 200, pp. 1-11, ISSN:1768-3254 Accesso ONLINE all'editore

Cecilia Ferrantini, Josè Manuel Pioner, Luca Mazzoni, Francesca Gentile, Benedetta Tosi, Alessandra Rossi, Luiz Belardinelli, Chiara Tesi, Chiara Palandri, Rosanna Matucci, Elisabetta Cerbai, Iacopo Olivotto, Corrado Poggesi, Alessandro Mugelli, Raffaele Coppini (2018). Late sodium current inhibitors to treat exercise induced obstruction in hypertrophic cardiomyopathy: an in vitro study in human myocardium.. BRITISH JOURNAL OF PHARMACOLOGY, pp. 0-0, ISSN:1476-5381 DOI Accesso ONLINE all'editore

Del Bello F.; Bonifazi A.; Giorgioni G.; Cifani C.; Micioni Di Bonaventura M.V.; Petrelli R.; Piergentili A.; Fontana S.; Mammoli V.; Yano H.; Matucci R.; Vistoli G.; Quaglia W. (2018). 1-[3-(4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1) as a Model for the Rational Design of a Novel Class of Brain Penetrant Ligands with High Affinity and Selectivity for Dopamine D 4 Receptor. JOURNAL OF MEDICINAL CHEMISTRY, vol. 61, pp. 3712-3725, ISSN:0022-2623 DOI Accesso ONLINE all'editore

Nocentini, Alessio; Ceruso, Mariangela; Bua, Silvia; Lomelino, Carrie L.; Andring, Jacob T.; McKenna, Robert; Lanzi, Cecilia; Sgambellone, Silvia; Pecori, Riccardo; Matucci, Rosanna; Filippi, Luca; Gratteri, Paola; Carta, Fabrizio; Masini, Emanuela; Selleri, Silvia*; Supuran, Claudiu T. (2018). Discovery of β-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy. JOURNAL OF MEDICINAL CHEMISTRY, vol. 61, pp. 5380-5394, ISSN:0022-2623 DOI Accesso ONLINE all'editore

Aprile, Silvio; Canavesi, Rossana; Matucci, Rosanna; Bellucci, Cristina; Del Grosso, Erika; Grosa, Giorgio (2018). New insights in the metabolism of Oxybutynin: evidence of N-oxidation of propargylamine moiety and rearrangement to enaminoketone. XENOBIOTICA, vol. 48, pp. 478-487, ISSN:0049-8254 DOI

Laurino, Annunziatina; Landucci, Elisa; Resta, Francesco; De Siena, G; Matucci, Rosanna; Masi, Alessio; Raimondi, Laura (2017). 3-Iodothyroacetic acid (TA1), a by-product of thyroid hormone metabolism, reduces the hypnotic effect of ethanol without interacting at GABA-A receptors.. NEUROCHEMISTRY INTERNATIONAL, pp. 1-6, ISSN:0197-0186 DOI

Del Bello, Fabio; Bonifazi, Alessandro; Giorgioni, Gianfabio; Petrelli, Riccardo; Quaglia, Wilma; Altomare, Angela; Falcicchio, Aurelia; Matucci, Rosanna; Vistoli, Giulio; Piergentili, Alessandro (2017). Novel muscarinic acetylcholine receptor hybrid ligands embedding quinuclidine and 1,4-dioxane fragments. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 137, pp. 327-337, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Annamaria, Morelli; Erica, Sarchielli; Giulia, Guarnieri; Elisabetta, Coppi; Daniela, Pantano; Paolo, Comeglio; Pamela, Nardiello; Pugliese, Anna M.; Lara, Ballerini; Rosanna, Matucci; Stefano, Ambrosini; Giuseppe, Castronovo; Rosa, Valente; Benedetta, Mazzanti; Sandra, Bucciantini; Mario, Maggi; Fiorella, Casamenti; Pasquale, Gallina; Gabriella B., Vannelli (2017). Young human cholinergic neurons respond to physiological regulators and improve cognitive symptoms in an animal model of Alzheimer’s disease. FRONTIERS IN CELLULAR NEUROSCIENCE, vol. 11:339, pp. 1-17, ISSN:1662-5102 DOI

Del Bello, Fabio; Bonifazi, Alessandro; Giannella, Mario; Giorgioni, Gianfabio; Piergentili, Alessandro; Petrelli, Riccardo; Cifani, Carlo; Micioni Di Bonaventura, Maria Vittoria; Keck, Thomas M.; Mazzolari, Angelica; Vistoli, Giulio; Cilia, Antonio; Poggesi, Elena; Matucci, Rosanna; Quaglia, Wilma (2017). The replacement of the 2-methoxy substituent of N-((6,6-diphenyl-1,4-dioxan-2-yl)methyl)-2-(2-methoxyphenoxy)ethan-1-amine improves the selectivity for 5-HT1A receptor over α1-adrenoceptor and D2-like receptor subtypes. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 125, pp. 233-244, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Del Bello F, Bonifazi A, Giorgioni G, Petrelli R, Quaglia W, Altomare A, Falcicchio A, Matucci R, Vistoli G, Piergentili A (2017). Novel muscarinic acetylcholine receptor hybrid ligands embedding quinuclidine and 1,4-dioxane fragments.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 137, pp. 327-337, ISSN:1768-3254 DOI Accesso ONLINE all'editore

Carosati, Emanuele; Cosimelli, Barbara; Ioan, Pierfranco; Severi, Elda; Katneni, Kasiram; Chiu, Francis C. K.; Saponara, Simona; Fusi, Fabio; Frosini, Maria; Matucci, Rosanna; Micucci, Matteo; Chiarini, Alberto; Spinelli, Domenico; Budriesi, Roberta (2016). Understanding Oxadiazolothiazinone Biological Properties: Negative Inotropic Activity versus Cytochrome P450-Mediated Metabolism. JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, pp. 3340-3352, ISSN:0022-2623 DOI Accesso ONLINE all'editore

Laurino, A; Matucci, R; Vistoli, G; Raimondi, L. (2016). 3-iodothyronamine (T1AM), a novel antagonist of muscarinic receptors.. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 15, pp. 35-42, ISSN:0014-2999

Matucci, Rosanna; Nesi, Marta; Martino, Maria Vittoria; Bellucci, Cristina; Manetti, Dina; Ciuti, Elisa; Mazzolari, Angelica; Dei, Silvia; Guandalini, Luca; Teodori, Elisabetta; Vistoli, Giulio; Romanelli, Maria Novella (2016). Carbachol dimers as homobivalent modulators of muscarinic receptors. BIOCHEMICAL PHARMACOLOGY, vol. 108, pp. 90-101, ISSN:0006-2952 DOI

Del Bello, Fabio; Bargelli, Valentina; Cifani, Carlo; Gratteri, Paola; Bazzicalupi, Carla; Diamanti, Eleonora; Giannella, Mario; Mammoli, Valerio; Matucci, Rosanna; Micioni Di Bonaventura, Maria Vittoria; Piergentili, Alessandro; Quaglia, Wilma; Pigini, Maria (2015). Antagonism/agonism modulation to build novel antihypertensives selectively triggering I<inf>1</inf>-imidazoline receptor activation. ACS MEDICINAL CHEMISTRY LETTERS, vol. 6, pp. 496-501, ISSN:1948-5875 DOI Accesso ONLINE all'editore

N. Lombardi;M. C. Lenti;R. Matucci;A. Mugelli;A. Vannacci (2015). Ticagrelor-related dyspnea: An underestimated and poorly managed event?. INTERNATIONAL JOURNAL OF CARDIOLOGY, vol. 179, pp. 238-239, ISSN:0167-5273 DOI Accesso ONLINE all'editore

Defant, Andrea; Mancini, Ines; Matucci, Rosanna; Bellucci, Cristina; Dosi, Federico; Malferrari, Danilo; Fabbri, Daniele (2015). Muscarine-like compounds derived from a pyrolysis product of cellulose. ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 13, pp. 6291-6298, ISSN:1477-0520 DOI Accesso ONLINE all'editore

Flavia Varano; Daniela Catarzi; Vittoria Colotta; Lucia Squarcialupi; Rosanna Matucci (2014). 1,2,4-Benzothiadiazine-1,1-dioxide Derivatives as Ionotropic Glutamate Receptor Ligands: Synthesis and Structure–Activity Relationships. ARCHIV DER PHARMAZIE, pp. 777-785, ISSN:0365-6233 DOI

Bonifazi A; Yano H; Del Bello F; Farande A; Quaglia W; Petrelli R; Matucci R; Nesi M; Vistoli G; Ferré S; Piergentili A. (2014). Synthesis and biological evaluation of a novel series of heterobivalent muscarinic ligands based on xanomeline and 1-[3-(4-butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1). JOURNAL OF MEDICINAL CHEMISTRY, vol. 57, pp. 9065-9077, ISSN:0022-2623 DOI

Del Bello F; Bonifazi A; Quaglia W; Mazzolari A; Barocelli E; Bertoni S; Matucci R; Nesi M; Piergentili A; Vistoli G. (2014). Mode of interaction of 1,4-dioxane agonists at the M2 and M3 muscarinic receptor orthosteric sites.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 24, pp. 3255-3259, ISSN:0960-894X DOI

Spinelli D; Budriesi R; Cosimelli B; Severi E; Micucci M; Baroni M; Fusi F; Ioan P; Cross S; Frosini M; Saponara S; Matucci R; Rosano C; Viale M; Chiarini A; Carosati E. (2014). Playing with opening and closing of heterocycles: using the cusmano-ruccia reaction to develop a novel class of oxadiazolothiazinones, active as calcium channel modulators and P-glycoprotein inhibitors.. MOLECULES, vol. 19, pp. 16543-16572, ISSN:1420-3049 DOI

Maria Vittoria Martino; Serena Scapecchi; Cristina Bellucci; Marta Nesi; Elisa Ciuti; Silvia Dei; Luca Guandalini; Dina Manetti; Elisabetta Teodori; Rosanna Matucci; Giulio Vistoli; Maria Novella Romanelli (2013). Design, Synthesis and binding affinity of carbachol dimers as bitopic ligands. In: 31 th Camerino-Cyprus-Noordwijkerhout Symposium, Camerino, 19-23 Maggio 2013, Università degli studi di Camerino, pp. 91-91.

F. Varano; D. Catarzi; V. Colotta; L. Squarcialupi; R. Matucci. (2013). 2-Hydroxy-1,2,4-benzothiadiazin-1,1-dioxide derivatives as new antagonists of ionotropic glutamate receptors. In: 22st National Meeting on Medicinal Chemistry, Roma, 10-13 september 2013, d, pp. P.CD.21-P.CD.21.

Bolchi C; Valoti E; Binda M; Fasoli F; Ferrara R; Fumagalli L; Gotti C; Matucci R; Vistoli G; Pallavicini M (2013). Design, synthesis and binding affinity of acetylcholine carbamoyl analogues. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, pp. 6481-6485, ISSN:0960-894X DOI Accesso ONLINE all'editore

Maria Elena Manni; Gaetano De Siena; Alessandro Saba; Maja Marchini; Elisa Landucci; Elisabetta Gerace; Marina Zazzeri; Claudia Musilli; Domenico Pellegrini-Giampietro; Rosanna Matucci; Riccardo Zucchi; Laura Raimondi (2013). Pharmacological effects of 3-iodothyronamine (T1AM) in mice include facilitation of memory acquisition and retention and reduction of pain threshold. BRITISH JOURNAL OF PHARMACOLOGY, vol. 168, pp. 354-362, ISSN:0007-1188

D. Catarzi; F. Varano; V. Colotta; L. Squarcialupi; R. Matucci; L. di Cesare Mannelli; M.Zanardelli (2013). Synthesis and Pharmacological evaluation of some new 8-substitute-7-trifluoromethyl-4,5-dihydro-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates as AMPA/Kainate receptor antagonists. In: 22st National Meeting on Medicinal Chemistry, Roma, 10-13 september 20013, d, pp. P.CD.03-P. CD. 03.

Del Bello F; Barocelli E; Bertoni S; Bonifazi A; Camalli M; Campi G; Giannella M; Matucci R; Nesi M; Pigini M; Quaglia W; Piergentili A. (2012). 1,4-dioxane, a suitable scaffold for the development of novel M₃ muscarinic receptor antagonists.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, pp. 1783-1787, ISSN:0022-2623 DOI

C. Cellai; M. Balliu; A. Laurenzana; L. Guandalini; R. Matucci; D. Miniati; E. Torre; A. Nebbioso; V. Carafa; L. Altucci; M. N. Romanelli; F. Paoletti (2012). The new low-toxic histone deacetylase inhibitor S-(2) induces apoptosis in various acute myeloid leukemia cells. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. 16, pp. 1758-1765, ISSN:1582-1838 DOI

M.P. Giovannoni; A. Graziano; R. Matucci; M. Nesi; N. Cesari; C. Vergelli; C. Biancalani; L. Crocetti; A. Cilibrizzi; V. Dal Piaz (2011). Synthesis and evaluation as PDE4 inhibitors of pyrimidine-2,4-dione derivatives. DRUG DEVELOPMENT RESEARCH, vol. 72, pp. 274-288, ISSN:0272-4391 DOI

Carocci A; Lentini G; Catalano A; Cavalluzzi MM; Bruno C; Muraglia M; Colabufo NA; Galeotti N; Corbo F; Matucci R; Ghelardini C; Franchini C. (2010). Chiral aryloxyalkylamines: Selective 5-HT(1B/1D) activation and analgesic activity. CHEMMEDCHEM, vol. 5, pp. 696-704, ISSN:1860-7179 DOI

S. Scapecchi; M. Nesi; R. Matucci; C. Bellucci; M. Buccioni; S. Dei; L. Guandalini; D. Manetti; C. Martelli; E. Martini; G. Marucci; F. Orlandi; M. N. Romanelli; E. Teodori; R. Cirilli (2010). Synthesis, Affinity Profile and Functional Activity of Potent Chiral Muscarinic Antagonists with a Pyrrolidinylfuran Structure. JOURNAL OF MEDICINAL CHEMISTRY, vol. 53 (1), pp. 201-207, ISSN:1520-4804 DOI Accesso ONLINE all'editore

Ghelardini C; Desaphy JF; Muraglia M; Corbo F; Matucci R; Dipalma A; Bertucci C; Pistolozzi M; Nesi M; Norcini M; Franchini C; Camerino DC. (2010). Effects of a new potent analog of tocainide on hNav1.7 sodium channels and in vivo neuropathic pain models.. NEUROSCIENCE, vol. 169, pp. 863-873, ISSN:0306-4522

Piergentili A; Quaglia W; Del Bello F; Giannella M; Pigini M; Barocelli E; Bertoni S; Matucci R; Nesi M; Bruni B; Di Vaira M. (2009). Properly substituted 1,4-dioxane nucleus favours the selective M3 muscarinic receptor activation.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 17, pp. 8174-8185, ISSN:1464-3391

C.Franchini; M.Muraglia; F.Corbo; M.Florio; A.Di Mola; A.Rosato; R.Matucci; M.Nesi; F.van Bambeke; C.Vitali (2009). Synthesis and biological evaluation of 2-mercapto-1,3-benzothiazole derivatives with potential antimicrobial activity. ARCHIV DER PHARMAZIE, vol. 342, pp. 605-613, ISSN:1521-4184 Accesso ONLINE all'editore

S. Scapecchi; M. Nesi; R. Matucci; C. Bellucci; M. Buccioni; S. Dei; L. Guandalini; D. Manetti; E. Martini; G. Marucci; M.N. Romanelli; E. Teodori; R. Cirilli. (2008). Synthesis and pharmacological characterization of chiral pyrrolidinylfuran derivatives: the discovery of new functionally selective muscarinic agonists. JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, pp. 3905-3912, ISSN:0022-2623 DOI

Dei, Silvia; Bellucci, Cristina; Buccioni, M.; Ferraroni, Marta; Guandalini, Luca; Manetti, Dina; Marucci, G.; Matucci, Rosanna; Nesi, Marta; Romanelli, MARIA NOVELLA; Scapecchi, Serena; Teodori, Elisabetta (2008). Muscarinic antagonists with multiple stereocenters: synthesis, affinity profile and functional activity of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine sulfoxide derivatives. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, pp. 5490-5500, ISSN:0968-0896 DOI

F.LAPI; E.CECCHI; C.PEDONE; F.ATTANASIO; G.BANCHELLI; A.VANNACCI; M.DI PIRRO; M.MOSCHINI; V.BERNI; R.MATUCCI; E.CINI; A.SCALIA; E.TENDI; A.MUGELLI (2008). Safety aspects of iodinated contrast media related to their physicochemical properties: a pharmacoepidemiology study in two Tuscany hospitals. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, vol. 64, pp. 723-737, ISSN:0031-6970

A. Piergentili; W. Quaglia; M. Giannella; F. Del Bello; M. Buccioni; M. Nesi; R. Matucci (2008). Rapid novel divergent synthesis and muscarinic agonist profile of all four optical isomers of N,N,N-trimethyl(6-methyl-1,4-dioxan-2-yl)methanaminium iodide.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, pp. 614-618, ISSN:0960-894X

G. VISTOLI; A. PEDRETTI; B. TESTA; R. MATUCCI (2007). The conformational and property space of acetylcholine bound to muscarinic receptors: an entropy component accounts for the subtype selectivity of acetylcholine. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 464, pp. 112-121, ISSN:0003-9861, Attuale:ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, USA, NY, 10010-1710 Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445:

M. Nesi; R. Matucci; E. Cerbai; L. Raimondi; A. Mugelli (2007). The effect of losartan on expression of beta-adrenoceptors in cardiomyocytes of diabetic and normoglycemic rats. In: ISHR, vol. 42, pp. S30-S31.

Filomena Corbo; Carlo Franchini; Giovanni Lentini; Marilena Muraglia; Carla Ghelardini; Rosanna Matucci; Nicoletta Galeotti; Elisa Vivoli; Vincenzo Tortorella (2007). Synthesis and biological evaluation of chiral α-aminoanilides with central antinociceptive activity. JOURNAL OF MEDICINAL CHEMISTRY, vol. 50, pp. 1907-1915, ISSN:0022-2623 DOI Accesso ONLINE all'editore

Dei, Silvia; Bellucci, Cristina; Buccioni, M.; Ferraroni, Marta; Guandalini, Luca; Manetti, Dina; Martini, Elisabetta; Marucci, G.; Matucci, Rosanna; Nesi, Marta; Romanelli, MARIA NOVELLA; Scapecchi, Serena; Teodori, Elisabetta (2007). SYNTHESIS, AFFINITY PROFILE AND FUNCTIONAL ACTIVITY OF MUSCARINIC ANTAGONISTS WITH A 1-METHYL-2-(2,2-ALKYLARYL-1,3-OXATHIOLAN-5-YL)PYRROLIDINE STRUCTURE. JOURNAL OF MEDICINAL CHEMISTRY, vol. 50, pp. 1409-1413, ISSN:0022-2623 DOI

Scapecchi, S.; Matucci, R.; Bellucci, C.; Buccioni, M.; Cirilli, R.; Dei, S.; Ferretti, R.; Guandalini, L.; Martelli, C.; Manetti, D.; Martini, E.; Marucci, G.; Nesi, M.; Mnromanelli, M.N.Romanelli; Teodori, E.; Angeli, P. (2007). synthesis, chiral HPLC separation and pharmacological characterization of muscarinic furan derivatives. In: 16th Camerino-Noordwijkerhout symposium, Camerino, 9-13 Settembre 2007, Università degli Studi di Camerino, pp. 98-98.

E.CAROSATI; G.CRUCIANI; A.CHIARINI; R.BUDRIESI; P.IOAN; R.SPISANI; D.SPINELLI; B.COSIMELLI; F.FUSI; M.FROSINI; R. MATUCCI; F.GASPARRINI; A. CIOGLI; P.J. STEPHENS; F.J. DEVLIN (2006). Calcium channel antagonists discovered by a multidisciplinary approach.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, pp. 5206-5216, ISSN:0022-2623, American Chemical Society:1155 Sixteenth Street Northwest:Washington, DC 20036:(800)227-5558, EMAIL: service@acs.org, INTERNET: http://www.pubs.acs.org, Fax: (614)447-3671:

Scapecchi, Serena; Matucci, Rosanna; Bellucci, Cristina; Buccioni, M.; Dei, Silvia; Guandalini, Luca; Martelli, Cecilia; Manetti, Dina; Martini, Elisabetta; Marucci, G.; Nesi, Marta; Romanelli, MARIA NOVELLA; Teodori, Elisabetta; Gualtieri, Fulvio (2006). Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, pp. 1925-1931, ISSN:0022-2623 DOI

S. Scapecchi; R. Matucci; C. Bellucci; M. Buccioni; S. Dei; L. Guandalini; C. Martelli; D. Manetti; E. Martini; G. Marucci; M. Nesi; M.N.Romanelli; E. Teodori; P. Angeli (2006). Sintesi e valutazione farmacologica di derivati furanici e tetraidrofuranici a potenziale azione muscarinica. In: XXII Congresso Nazionale della Società Chimica Italiana, Firenze, 10-15 Settembre 2006, Società Chimica Italiana, pp. 197-197.

S. Dei; C. Bellucci; M. Buccioni; M. Ferraroni; L. Guandalini; D. Manetti; E. Martini; G. Marucci; R. Matucci; M. Nesi; M.N. Romanelli; S. Scapecchi; E. Teodori (2006). Antagonisti muscarinici a struttura 1,3-ossatiolano-2-pirrolidinica. In: XXII Congresso Nazionale della Società Chimica Italiana, Firenze, 10-15 Settembre 2006, Società Chimica Italiana, pp. 188-188.

C.Pedone; E.Cecchi; R.Matucci; M.Pahor; L.Carosella; R.Bernabei; A.Mugelli; GIFA Investigators (2005). Does aspirin attenuate the beneficial effect of ACE inhibitors in elderly people with heart failure?. DRUGS & AGING, vol. 22, pp. 605-614, ISSN:1170-229X, Adis International Limited:Private Bag 65901, Mairangi Bay, Auckland 1311 New Zealand:011 64 9 4770741, EMAIL: subs@adis.com, david.herrick@adis.co.nz, INTERNET: http://www.adis.com, Fax: 011 64 9 4770766: DOI

Dei, Silvia; Angeli, P.; Bellucci, Cristina; Buccioni, M.; Gualtieri, Fulvio; Marucci, G.; Manetti, Dina; Matucci, Rosanna; Romanelli, MARIA NOVELLA; Scapecchi, Serena; Teodori, Elisabetta (2005). Muscarinic subtype affinity and functional activity profile of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)pyrrolidine and 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine derivatives.. BIOCHEMICAL PHARMACOLOGY, vol. 69, pp. 1637-1645, ISSN:0006-2952 DOI

Serena Scapecchi; Cecilia Martelli; Elisabetta Martini; Cristina Bellucci; Silvia Dei; Fulvio Gualtieri; Rosanna Matucci; Maria Novella Romanelli; Elisabetta Teodori (2004). Synthesis and pharmacological characterization of diastereomeric and enantiomeric isomers of 1-methyl-2-(2-methyl-1,3-oxathiolane-5-yl)pyrrolidine 3-sulfoxides and their methyl iodides. In: XVIIIth Symposium on Medicinal Chemistry, Copenhagen and Malmoe, 15-19 agosto 2004, J . R. Prous, vol. 29, Suppl. A, pp. P238-P238.

S. SCAPECCHI; E. MARTINI; C. BELLUCCI; M. BUCCIONI; S. DEI; L. GUANDALINI; D. MANETTI; C. MARTELLI; G. MARUCCI; R. MATUCCI (2004). MOLECULAR MODULATION OF MUSCARINIC ANTAGONISTS. SYNTHESIS AND AFFINITY PROFILE OF 2,2-DIPHENYL-2-ETHYLTHIO-ACETIC ACID ESTERS DESIGNED TO PROBE THE BINDING SITE CAVITY. IL FARMACO, vol. 59, pp. 971-980, ISSN:0014-827X DOI

Teodori, Elisabetta; Baldi, Elisabetta; Dei, Silvia; Gualtieri, Fulvio; Romanelli, MARIA NOVELLA; Scapecchi, Serena; Bellucci, Cristina; Ghelardini, Carla; Matucci, Rosanna (2004). Design, synthesis and preliminary pharmacological evaluation of 4-aminopiperidine derivatives as N-type calcium channel blockers active on pain and neuropathic pain. JOURNAL OF MEDICINAL CHEMISTRY, vol. 47, pp. 6070-6081, ISSN:0022-2623, American Chemical Society:1155 Sixteenth Street Northwest:Washington, DC 20036:(800)227-5558, EMAIL: service@acs.org, INTERNET: http://www.pubs.acs.org, Fax: (614)447-3671: DOI

S. Scapecchi; E. Martini; C. Bellucci; S. Dei; L. Guandalini; D. Manetti; C. Martelli; G. Marucci; R. Matucci (2004). Modulazione molecolare di antagonisti muscarinici. Sintesi e valutazione farmacologica preliminare di esteri amminoalchil piperazinici e piperidinici dell'acido 2,2-difenil-2-etiltioacetico. In: XVII Convegno Nazionale della Divisione di Chimica Farmaceutica della Società Chimica Italiana, Pisa, 6-10 Settembre 2004, Società Chimica Italiana, pp. 180-180.

S. SCAPECCHI; C. MARTELLI; P. ANGELI; C. BELLUCCI; M. BUCCIONI; S. DEI; F. GUALTIERI; G. MARUCCI; R. MATUCCI; M. ROMANELLI; E. TEODORI (2004). MOLECULAR MODULATION OF MUSCARINIC ANTAGONISTS. SYNTHESIS AND PHARMACOLOGICAL PROFILE OF 2,2-DIPHENYL-2-ETHYLTHIOACETIC AND 3,3-DIPHENYL-3-ETHYLTHIOPROPIONIC ACID DERIVATIVES CHARACTERIZED BY A DIPEPTIDE SPACER. LETTERS IN DRUG DESIGN & DISCOVERY, vol. 1, pp. 91-96, ISSN:1570-1808

Serena Scapecchi; Piero Angeli; Cristina Bellucci; Silvia Dei; Fulvio Gualtieri; Cecilia Martelli; Gabriella Marucci; Rosanna Matucci; Maria Novella Romanelli; Elisabetta Teodori (2003). Molecular modulation of muscarinic antagonists. Synthesis and pharmacological profile of 2,2-diphenyl-2-ethylthioacetic acid and 3,3-diphenyl-3-ethylthiopropionic acid derivatives characterized by a dipeptide spacer. In: 14th Camerino-Noordwijkerhout Symposium Ongoing Progress in the Receptor Chemistry, Camerino (MC), 7-11 settembre 2003, Università degli studi di Camerino, pp. 88-88.

Serena Scapecchi; Cecilia Martelli; Elisabetta Martini; Cristina Bellucci; Silvia Dei; Fulvio Gualtieri; Luca Guandalini; Rosanna Matucci; Maria Novella Romanelli; Elisabetta Teodori (2003). Highly chiral muscarinic ligands: synthesis and affinity of diastereomeric and enantiomeric isomers of 1-methyl-2-(2-methyl-1,3-oxathiolane-5-yl)pyrrolidine 3-sulfoxides and their methyl iodides. In: Polish-Austrian-German-Hungarian-Italian Joint Meeting on Medicinal Chemistry, Cracovia (PL), 15-18 ottobre 2003, Jagellonian University, Krakow (PL), pp. 57-57.

Elisabetta Teodori; Elisabetta Baldi; Cristina Bellucci; Silvia Dei; Carla Ghelardini; Fulvio Gualtieri; Rosanna Matucci; Maria Novella Romanelli; Serena Scapecchi (2003). Design, synthesis and preliminary pharmacological evaluation of alkylderivatives of 4-aminopiperidine as N-type calcium channels blockers. In: XXI Congresso Nazionale della Società Chimica Italiana SCI2003, Torino, 22-27 giugno 2003, Società Chimica Italiana, pp. FA-CO-021-FA-CO-021.

Dei, Silvia; Bellucci, Cristina; Buccioni, M.; Ferraroni, Marta; Gualtieri, Fulvio; Guandalini, Luca; Manetti, Dina; Matucci, Rosanna; Romanelli, MARIA NOVELLA; Scapecchi, Serena; Teodori, Elisabetta (2003). Synthesis and Cholinergic Affinity of Diastereomeric and Enantiomeric Isomers of 1-Methyl-2-(2-methyl-1,3-dioxolan-4-yl)-pyrrolidine, 1-Methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine and of Their Iodomethylates. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11, pp. 3153-3164, ISSN:0968-0896 DOI

L. Raimondi; G. Banchelli; R. matucci; F. Stillitano; R. Pirisino (2002). The direct stimulation of gi protein by neuropeptide Y in the rat cardiac left ventricle. BIOCHEMICAL PHARMACOLOGY, vol. 63, pp. 2063-2068, ISSN:0006-2952

Silvia Dei; Cristina Bellucci; Michela Buccioni; Marta Ferraroni; Fulvio Gualtieri; Luca Guandalini; Dina Manetti; Rosanna Matucci; Maria Novella Romanelli; Serena Scapecchi; Katia Varani; Elisabetta Teodori (2002). Sintesi e affinità per i recettori colinergici degli stereoisomeri della 1-metil-2-(2-metil-1,3-diossolan-4-il)pirrolidina, della 1-metil-2-(2-metil-1,3-ossatiolan-5-il)pirrolidina e dei loro iodometilati. In: XVI convegno nazionale della Divisione di Chimica Farmaceutica, Società Chimica Italiana, Sorrento, 18-22 settembre 2002, Società Chimica Italiana Divisione di Chimica Farmaceutica, pp. 39-39.

Silvia Dei; Elisabetta Teodori; Cristina Bellucci; Fulvio Gualtieri; Luca Guandalini; Rosanna Matucci; Serena Scapecchi; Katia Varani; Marta Ferraroni (2001). (1,3-Dioxolane)- and (1,3-oxathiolane)-2-pyrrolidines: molecular hybrids with potential anti-Alzheimer activity. In: Hungarian-German-Italian-Polish Joint Meeting on Medicinal Chemistry, Budapest, 2-6 settembre 2001, Hungarian Chemical Society Organic and Medicinal Chemistry Division, pp. 72-72.

F. STILLITANO; L. SARTIANI; R. MATUCCI; P. DEPAOLI; C. PERFETTI; M. MACCHERINI; G. SANI; E. CERBAI; A. MUGELLI (2001). Beta1 and Beta2 adrenoceptors in human ventricular myocytes: a study of their proportion and signaling pathways.. PHARMACOLOGICAL RESEARCH, vol. 43, pp. 16-16, ISSN:1043-6618

Scapecchi, Serena; Marucci, G.; Matucci, Rosanna; Angeli, P.; Bellucci, Cristina; Buccioni, M.; Dei, Silvia; Gualtieri, Fulvio; Manetti, Dina; Romanelli, MARIA NOVELLA; Teodori, Elisabetta (2001). Structure-activity relationships in 2,2-diphenyl-2-ethylthioacetic acid esters: unexpected agonistic activity in a series of muscarinic antagonists.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 9, pp. 1165-1174, ISSN:0968-0896

A. Mugelli; E. Cerbai; C. Tesi; R. Matucci; G. Lonardo; N. Piroddi; L. Sartiani; F. Stillitano; M. Di Pirro; C. Poggesi (2001). New endogenous triggers of atrial fibrillation. In: IV international meeting. Atrial fibrillation 2001., Cepi, pp. 21-23.

R. PIRISINO; BANCHELLI G.; MATUCCI R.; STILLITANO F.; PIRISINO R.; MUGELLI A (2001). The effect of neuropeptide Y(NPY)on the GTPase activity of the rat left ventricle Gi proteins. BRITISH JOURNAL OF PHARMACOLOGY, vol. 133, pp. 25P-25P, ISSN:0007-1188, Nature Publishing Group:Brunel Road Houndmills, Basingstoke RG21 6XS United Kingdom:011 44 20 78334000, EMAIL: institutions@natureny.com, INTERNET: http://www.nature.com, Fax: 011 44 20 78434640:

Cerbai E; Sartiani L; DePaoli P; Matucci R; Davoli G; DiCiolla F; Lisi G; Maccherini M; Sani G; Mugelli A. (2000). Electrophysiologic effects of lercanidipine on repolarizing potassium currents.. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, vol. 36, pp. 584-591, ISSN:0160-2446

B. BIAGIOLI; M. MACCHERINI; R. MATUCCI; A. MUGELLI; F. CARLUCCI; A. TABUCCHI (2000). OXIDATIVE STRESS:CLINICAL IMPLICATIONS IN CARDIAC SURGERY. ITALIAN HEART JOURNAL, vol. 1, pp. 43-45, ISSN:1129-471X

Cerbai E; Sartiani L; DePaoli P; Matucci R; Davoli G; DiCiolla F; Lisi G; Maccherini M; Sani G; Mugelli A. (2000). Electropysiologic effects of lercanidipine on repolarizing potassium currents. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, vol. 36, pp. 584-591, ISSN:0160-2446 DOI Accesso ONLINE all'editore

GHELARDINI C.; GALEOTTI N.; MATUCCI R.; BELLUCCI C.; GUALTIERI F.; CAPACCIOLI S.; QUATTRONE A.; BARTOLINI A. (1999). Antisense knockdowns of M1 receptors induces transient anterograde amnesia in mice. NEUROPHARMACOLOGY, vol. 38, pp. 339-348, ISSN:0028-3908 DOI

B. Bianchi; R. Matucci; A. Danesi; R. Rossi; P. Ipponi; B. Giannotti; O. Johansson; P. Cappugi (1999). Characterization of [3H]substance P binding sites in human skin.. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, vol. 12, pp. 6-10, ISSN:0926-9959

S. PIERETTI; V. DAL PIAZ; R. MATUCCI; M. GIOVANNONI; A. GALLI (1999). ANTINOCICEPTIVE ACTIVITY OF A 3(2H)-PYRIDAZINONE DERIVATE IN MICE. LIFE SCIENCES, vol. 65, pp. 1381-1394, ISSN:0024-3205

C. Cellai; R. Matucci; A. M. Vannucchi; F. Paoletti (1999). Constitutive muscarinic receptors are involved in the growth and differentiation of friend erythroleukemia cells.. JOURNAL OF CELLULAR PHYSIOLOGY, vol. 178, pp. 333-340, ISSN:0021-9541 Accesso ONLINE all'editore

P. Angeli; C. Bellucci; S. Dei; F. Gualtieri; D. Manetti; G. Marucci; R. Matucci; M.N.Romanelli; S. Scapecchi; E. Teodori (1999). Unexpected agonistic activity in a series of muscarinic antagonists. In: 12th Camerino-Noordwijkerhout Symposium Receptor chemistry towards the third millennium, Camerino, 5-9 Settembre 1999, Università degli Studi di Camerino, pp. 104-104.

R. MATUCCI; MF.OTTAVIANI; M.BARBIERI M; E.CERBAI; A.MUGELLI (1997). Protective effect of darodipine, a calcium antagonist, on rat cardiomyocytes against oxygen radical-mediated injury. BRITISH JOURNAL OF PHARMACOLOGY, vol. 122, pp. 1353-1360, ISSN:0007-1188

E. Barciulli; V. Ricca; E. Mannucci; R. Matucci; P.L. Cabras; M. Di Bernardo (1997). Sovrappeso indotto da farmaci. In: C.M. Rotella, V. Ricca, E. Mannucci. L'obesità: manuale per la diagnosi e la terapia, pp. 199-213, Firenze: S.E.E. Firenze.

S.M. Rizzello; R. Matucci; S. Carrara; C.M. Rotella (1997). Regolazione fisiologica dell'apporto di cibo. In: C.M. Rotella, V. Ricca, E. Mannucci. L'obesità: manuale per la diagnosi e la terapia, pp. 75-91, Firenze: S.E.E. Firenze.

R.Matucci; B.Bianchi; L.Mantelli; C.Ghelardini; G.B.Vannelli; M.Maggi (1996). Influence of oestrogens on muscarinic receptor density and contractile response in the guinea-pig uterus.. JOURNAL OF REPRODUCTION AND FERTILITY, vol. 107, pp. 153-160, ISSN:0022-4251

R. Matucci; B. Bianchi; M.F. Ottaviani; S. Campana; F. Bennardini; F. Franconi (1996). Carbon centered radicals reduce the density of L-type calcium channels in rat cardiac membranes.. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 223, pp. 85-90, ISSN:0006-291X

D. MANETTI; M. ROMANELLI; A. BARTOLINI; S. DEI; C. GHELARDINI; F. GUALTIERI; R. MATUCCI; S. SCAPECCHI; E. TEODORI (1996). REDUCED FLEXIBILITY ANALOGS OF ANALGESIC AND COGNITION-ENHANCING A-TROPANYL ESTERS. ARCHIV DER PHARMAZIE, vol. 329, pp. 105-111, ISSN:0365-6233

Teodori E; Dei S; Romanelli M; Scapecchi S; Gualtieri F; Angeli P; Marucci G; Matucci R. (1994). 1,3-oxathiolane muscarinic ligands modified at the cationic head.. IL FARMACO, vol. 49, pp. 305-312, ISSN:0014-827X

M.N. Romanelli; A. Bartolini; S. Dei; C. Ghelardini; F. Gualtieri; D. Manetti; R. Matucci; S. Scapecchi; E. Teodori (1994). Analoghi a ridotta flessibilità molecolare di nuovi farmaci ad azione nootropa ed analgesica. In: XI Convegno Nazionale Divisione di Chimica Farmaceutica Società Chimica Italiana, Bari, 2-5 Ottobre 1994, Società Chimica Italiana Divisione di Chimica Farmaceutica, pp. 96-96.

Romanelli, MARIA NOVELLA; Ghelardini, Carla; Dei, Silvia; Matucci, Rosanna; Mori, Francesca; Scapecchi, Serena; Teodori, Elisabetta; Bartolini, Alessandro; Galli, Alessandro; Giotti, Alberto; Gualtieri, Fulvio (1993). SYNTHESIS AND BIOLOGICAL ACTIVITY OF A SERIES OF ARYL TROPANYL ESTERS AND AMIDES CHEMICALLY RELATED TO 1H-INDOLE-3-CARBOXYLIC ACID ENDO 8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL ESTER. ARZNEIMITTEL-FORSCHUNG, vol. 43 (II), pp. 913-918, ISSN:0004-4172

F. FRANCHINI; F. CHIAIA NOJA; F. CORBO; G. LENTINI; V. TORTORELLA; A. BARTOLINI; C. GHELARDINI; R. MATUCCI; A. GIOTTI (1993). STEREOSELECTIVITY IN CENTRAL ANALGESIC ACTION OF TOCAINIDE AND ITS ANALOGS. CHIRALITY, vol. 5, pp. 135-142, ISSN:0899-0042

R. PIRISINO; BANCHELLI G; IGNESTI G; MANTELLI L; MATUCCI R; RAIMONDI L; BUFFONI F (1993). Calcium modulatory properties of 2,6-dibutylbenzylamine (B25) in rat isolated vas deferens, cardiac and smooth muscle preparations.. BRITISH JOURNAL OF PHARMACOLOGY, vol. 109, pp. 1038-1045, ISSN:0007-1188, Nature Publishing Group:Brunel Road Houndmills, Basingstoke RG21 6XS United Kingdom:011 44 20 78334000, EMAIL: institutions@natureny.com, INTERNET: http://www.nature.com, Fax: 011 44 20 78434640:

Matucci R; Ottaviani M; Campana S; Bianchi B; Bennardini F; Moneti G; Giotti A; Franconi F (1992). Do ethoxy radicals reduce 3H-nitrendipine binding in rat cardiac membranes?. PHARMACOLOGICAL RESEARCH, vol. 26, pp. 151-159, ISSN:1043-6618

C. GHELARDINI; A. GIOTTI; F. GUALTIERI; R. MATUCCI; M. ROMANELLI; S. SCAPECCHI; E. TEODORI; A. BARTOLINI (1992). PRESYNAPTIC AUTO- AND HETERO-RECEPTORS IN THE CHOLINERGIC REGULATION OF PAIN. In: 8. TRENDS IN RECEPTOR RESEARCH, pp. 95-114, ELSEVIER SCIENCE PUBLISHERS B. V. AMSTERDAM: P. ANGELI, U. GULINI, W. QUAGLIA.

Franconi F; Bennardini F; Campana S; Failli P; Matucci R; Stendardi I; Giotti A (1990). Effect of taurine, L-cysteic and orthanilic acids on cardiac tension.. PROGRESS IN CLINICAL AND BIOLOGICAL RESEARCH, vol. 351, pp. 175-184, ISSN:0361-7742

R. Matucci; F. Franconi (1989). Preparazione e frazionamento dei componenti subcellulari. In: P. Dolara, F. Franconi, A. Mugelli. Farmacologia e tossicologia sperimentale, pp. 65-80, Bologna: Pitagora Editrice.

Mantelli L; Capanni L; Corti V; Bennardini F; Matucci R; Ledda F (1988). Influence of lithium on the positive inotropic effect of phenylephrine and isoprenaline in guinea-pig heart.. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 150, pp. 123-129, ISSN:0014-2999

Bennardini F; Failli P; Matucci R; Bartolini A; Morandini D; Polenzani L; Franconi F; Giotti A (1987). The effect of taurine on excitatory receptor binding in rat hippocampal membranes. ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, vol. 217, pp. 325-330, ISSN:0065-2598

Bennardini F; Failli P; Matucci R; Bartolini A; Malcangio M; Massari M; Franconi F; Giotti A (1987). L-arginine methylester reduces Ca2+/Cl(-)-dependent L-[3H]glutamate binding and Ca2+-activated neutral protease activity in rat hippocampal membranes.. FUNDAMENTAL & CLINICAL PHARMACOLOGY, vol. 1, pp. 297-306, ISSN:0767-3981

Matucci R; Bennardini F; Sciammarella ML; Baccaro C; Stendardi I; Franconi F; Giotti A. (1987). [3H]-nitrendipine binding in membranes obtained from hypoxic and reoxygenated heart.. BIOCHEMICAL PHARMACOLOGY, vol. 36, pp. 1059-1062, ISSN:0006-2952

Franconi F; Bennardini F; Matucci R; Stendardi I; Failli P; Manzini S; Giotti A (1986). Functional and binding evidence of taurine inhibition of alpha-adrenoceptor effects on guinea-pig ventricle.. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, vol. 18, pp. 461-468, ISSN:0022-2828

Masini E; Franconi F; Peduto V; Pieraccioli E; Matucci R; Novelli G. (1986). Liver function following hypovolemic hypotension in rats anaesthetized with halothane or enflurane.. PHARMACOLOGICAL RESEARCH COMMUNICATIONS, vol. 18, pp. 847-856, ISSN:0031-6989

Franconi F; Failli P; Stendardi I; Matucci R; Bennardini F; Baccaro C; Giotti A. (1986). Positive inotropic effect of some taurine-related compounds on guinea-pig ventricular strips perfused with low calcium medium.. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 124, pp. 129-133, ISSN:0014-2999

Franconi F; Stendardi I; Failli P; Matucci R; Baccaro C; Montorsi L; Bandinelli R; Giotti A (1985). The protective effects of taurine on hypoxia (performed in the absence of glucose) and on reoxygenation (in the presence of glucose) in guinea-pig heart.. BIOCHEMICAL PHARMACOLOGY, vol. 34, pp. 2611-2615, ISSN:0006-2952

Franconi F; Stendardi I; Matucci R; Bennardini F; Baccaro C; Giotti A (1985). A protective effect of taurine on "hypoxic" and "reoxygenated" guinea pig heart.. PROGRESS IN CLINICAL AND BIOLOGICAL RESEARCH, vol. 179, pp. 177-182, ISSN:0361-7742

Franconi F; Bennardini F; Stendardi I; Matucci R; Dini G; Giotti A (1985). Effects of leucine methylester on guinea-pig atria.. ACTA PHARMACOLOGICA ET TOXICOLOGICA, vol. 57, pp. 141-146, ISSN:0001-6683

Baccaro C; Bennardini F; Dini G; Franconi F; Giotti A; Matucci R; Minuti P (1985). Cardiac hypoxia and subsequent reoxygenation: sensitivity to L-arginine methylester. BRITISH JOURNAL OF PHARMACOLOGY, vol. 87, pp. 649-656, ISSN:0007-1188

Franconi F; Stendardi I; Matucci R; Failli P; Bennardini F; Antonini G; Giotti A (1984). Inotropic effect of taurine in guinea-pig ventricular strips.. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 102, pp. 511-514, ISSN:0014-2999

Bennardini F; Amerini S; Franconi F; Ledda F; Mantelli L; Matucci R; Mugelli A; Sorbi C (1984). On the presence of H1-receptors in various sections of guinea-pig heart: a correlation between binding and functional studies.. AGENTS AND ACTIONS, vol. 15, pp. 167-171, ISSN:0065-4299

F. Franconi; S. Manzini; I. Stendardi; F. Bennardini; G. Antonini; P. Failli; R. Matucci; A. Giotti (1983). Differential inhibitory effect of taurine on contractile responses to potassium and noradrenaline in rabbit ear artery.. JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 35, pp. 46-48, ISSN:0022-3573

Franconi F; Stendardi I; Failli P; Antonini G; Bennardini F; Matucci R; Manzini S; Giotti A (1983). Taurine antagonizes the alpha-adrenergic-positive inotropic effect of phenylephrine.. PROGRESS IN CLINICAL AND BIOLOGICAL RESEARCH, vol. 125, pp. 51-59, ISSN:0361-7742

Franconi F; Martini F; Stendardi I; Matucci R; Zilletti L; Giotti A (1982). Effect of taurine on calcium levels and contractility in guinea-pig ventricular strips.. BIOCHEMICAL PHARMACOLOGY, vol. 31, pp. 3181-3185, ISSN:0006-2952

Rosanna MATUCCI

Biography

Graduated in Pharmaceutical Chemistry and Technology from the University of Florence maxima cum laude

Researcher at the Department of NEUROFARBA, University of Florence 2004-2022;

Retired as of November 1, 2022

Rosanna MATUCCI

Curriculum

EDUCATION: 1974-1980 Degree in Pharmaceutical Chemistry and Technology, University of Florence

PROFESSIONAL EXPERIENCES:

September 1980-March1981: Practical internship for admission to the state examination for licensure as a pharmacist.

1981: Habilitation to practice as a pharmacist.

1983-1989: Professional training grant from CNR, Department of Pharmacology, Florence, Italy.

1980-2000: Attends postgraduate courses and schools of national and international character

1990-2001: Technical officer, Florence Department of Pharmacology November 2001-2004: Confirmed researcher for the Faculty of Medicine, University of Florence, NEUROFARBA Department

2004-2022: Confirmed researcher for the Faculty of Pharmacy, University of Florence, Department NEUROFARBA

2006-2022: Adjunct professor for the Faculty of Pharmacy

from November 1, 2022 retired researcher

TEACHING ASSIGNMENTS:

Lecturer of the integrated course of Pharmacotoxicology and Pharmaceutical Galenics for the Degree Course in Biomedical Laboratory Techniques (2000-2004)

Adjunct lecturer of the integrated course of Pharmacotoxicology and Pharmaceutical Galenics for the Degree Course in Biomedical Laboratory Techniques (2005-2012)

Course holder of General Pharmacology for the Bachelor of Science in Pharmacy (2010-2014)

Course holder of General Pharmacology and Pharmacological Assays for the Bachelor of Science in Applied Pharmaceutical Sciences (2004-2022)

Delegate of Orientation and Tutoring Member of the Teaching Committee Member of the Course Coordination Committee

Teaching activities in the Graduate School of Hospital Pharmacy

Teaching activities in the PhD School of Pharmacology

OTHER TITLES Member of the organizing committee of the congress “Sulfur amino acids, peptides and related compounds” (San Miniato, Florence, October 6-9, 1986) Member of the Italian Society of Pharmacology

REVIEWER:

Cardiovascular Pharmacological Research

British Journal of Pharmacology

Rosanna MATUCCI

Interest

RESEARCH INTERESTS:
Cellular mechanisms of cardiac arrhythmias; Antiarrhythmic drugs
- Damage caused by models of hypoxia and hypoxia plus cardiac reoxygenation in experimental animals and involvement of oxygen free radicals: dihydropyridine binding studies
- radical species involved in reperfusion-induced damage following a period of ischemia in human models (explanted hearts): effect of calcium antagonists on radicals studied by electron spin resonance (EPR) techniques
-mechanism of action of neuropeptide Y (NPY) in GTPase activation at the level in the rat ventricle: evidence for direct stimulation of Gi proteins
-Binding studies for beta adrenergic receptors in human and rat cardiac myocytes in cardiovascular disease.
-collaboration with research centers to study muscarinic receptors in animal tissues and in cell lines stably expressing human (m1-m5) WT and mutated muscarinic receptors, allosteric mechanisms

-collaborations with research centers to study beta adrenergic receptors in cell lines stably expressing the three human receptor subtypes (WT and mutated), second messenger studies