Fiorella CASAMENTI

Ruolo attuale:: Professore Associato in Pensione
SSD:: BIO/14 - Farmacologia
Afferenza organizzativa:: Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino (NEUROFARBA)

Recapiti

	0552758286
	fiorella.casamenti(AT)unifi.it

Fiorella CASAMENTI

Orario di ricevimento (aggiornato al 20/10/2008) Il venerdi’ con orario 11.00-13.00

Fiorella CASAMENTI

Biografia

Fiorella Casamenti è nata a Seggiano (GR) il 10 maggio 1952. Si è laureata in Scienze Biologiche nel 1976 presso l’Università degli Studi di Firenze.

1981-2001: ha ricoperto il ruolo di Ricercatore Confermato presso il Dipartimento di Farmacologia dell’Università di Firenze, diventato successivamente Dipartimento di NEUROFARBA dell’Università di Firenze.

2001-2022 ha ricoperto il ruolo di Professore Associato di Farmacologia presso il Dipartimento di NEUROFARBA dell’Università di Firenze.

Novembre 2022: pensionamento

Fiorella CASAMENTI

Curriculum

Prof. Associato della Facoltà di Medicina e Chirurgia, SSD BIO 14

1976: Laurea in Scienze Biologiche, Università degli Studi di Firenze

1981-2001 Ricercatore a tempo indeterminate presso il DIP di Farmacologia, Università degli Studi di Firenze

2001-2022: Professore Associato di Farmacologia, Dipartimento di NEUROFARBA, Università degli Studi di Firenze

Beneficiaria di borse di studio per lavorare all’estero in laboratori di Neurofarmacologia

Relatore nvitato e moderatore a diversi Congressi Nazionali e Internazionali

Revisore per diverse Riviste Internazionali.

Membro delle Società: SIF, SINS, AIRIC, ENA and SfN.

I suoi interessi scientifici si sono concentrati principalmente su studi molecolari, cellulari e funzionali in modelli animali “in vivo” di malattie degenerative (demenza di Alzheimer e FTD) e infiammatorie (MS) del SNC.

I risultati di queste ricerche sono stati pubblicati in 122 articoli su prestigiose riviste internazionali,in oltre 30 articoli su libri internazionali e in oltre 500 abstract. Ha collaborato con importanti laboratori nazionali e internazionali.

Nel 2005 è stata PI di un progetto integrato (IP) della EC nell’ambito del 6FP “Nuove sostanze terapeutiche per le malattie neurodegenerative del SNC e SNP. L’applicazione dal titolo “ Sintesi di piccole molecole per il trattamento della malattia di Alzheimer basata sulla scoperta di nuovi bersagli terapeutici”, è stata finanziata dalla CE per la durata di 5 anni.

E’ stata coordinatore Scientifico e Responsabile Nazionale di progetti PRIN, titolare di progetti finanziati da Telethon, Regione Toscana, CRF, MPS e Università di Firenze.

Docente nella Facolta’ di Medicina di Firenze nel CDL Fisioterapia e CDL Infermieristica, nelle Scuole di Specializzazione di Farmacologia, Psichiatria, Neurologia e Neurofisiopatologia.

E’ stata tutore scientifico di diversi dottorandi in Farmacologia dell’Università degli Studi di Firenze

Da Novembre 2022 Fiorella Casamenti e’ in pensione di vecchiaia

Fiorella CASAMENTI

Interessi

Fiorella Casamenti, Professore Associato, BIO 14

Gli interessi principali della Prof.ssa Fiorella Casamenti sono stati di studiare, in modelli animali “in vivo”, i meccanismi neurodegenerativi coinvolti nella malattia di Alzheimer (AD), demenza Fronto Temporale (FTD) e Sclerosi Multipla.

Modelli in vivo di Alzheimer. Ha studiato gli aspetti patogenetici della malattia di Alzheimer in topi transgenici CRND8 con mutazione umana della proteina precursore dell'amiloide (APP) e in ratti iniettati intracerebro con il peptide amiloide Aß(1-42) e/o frammenti di esso, con eccitotossine e/o proteine batteriche non associate a malattie. In questi modelli ha condotto studi di immunoistochimica, molecolari e funzionali ed ha studiato l'effetto di farmaci antinfiammatori, neuroprotettivi e farmaci che correggono l'ipofunzione colinergica

Modello sperimentale di FTD. Ha studiato le analogie tra la neuropatia di pazienti affetti da taupatie e topi transgenici con la forma umana mutata di tau P301S

Modello sperimentale di Sclerosi Multipla Nel modello sperimentale di sclerosi multipla (EAE) ha studiato l'axonopatia associata alla cascata infiammatoria e l'effetto protettivo di farmaci quali la minociclina e statine.

Fiorella CASAMENTI

Pubblicazioni

Legenda

Contributo su rivista |

Articolo su libro |

Libro |

Contributo in atti di convegno (proceeding) |

Brevetto |

Curatela | Altro

Altro |

Tesi di Dottorato

Lana, Daniele; Branca, Jacopo Junio Valerio; Delfino, Giovanni; Giovannini, Maria Grazia; Casamenti, Fiorella; Nardiello, Pamela; Bucciantini, Monica; Stefani, Massimo; Zach, Petr; Zecchi-Orlandini, Sandra; Nosi, Daniele (2023). Morphofunctional Investigation in a Transgenic Mouse Model of Alzheimer’s Disease: Non-Reactive Astrocytes Are Involved in Aβ Load and Reactive Astrocytes in Plaque Build-Up. CELLS, vol. 12, pp. 0-0, ISSN:2073-4409 DOI Accesso ONLINE all'editore

Bucciantini Monica; Leri Manuela; Stefani Massimo; Casamenti Fiorella; Nardiello Pamela; (2021). Olive Polyphenols: Antioxidant and Anti-Inflammatory Properties. ANTIOXIDANTS, pp. 0-0, ISSN:2076-3921 DOI

bucciantini monica; leri manuela; pamela nardiello; fiorella casamenti; (2020). Garcinoic acid prevents β-amyloid (Aβ) deposition in the mouse brain. THE JOURNAL OF BIOLOGICAL CHEMISTRY, pp. 0-0, ISSN:0021-9258

Bilia, Anna Rita; Nardiello, Pamela; Piazzini, Vieri; Leri, Manuela; Bergonzi, Maria Camilla; Bucciantini, Monica; Casamenti, Fiorella (2019). Successful Brain Delivery of Andrographolide Loaded in Human Albumin Nanoparticles to TgCRND8 Mice, an Alzheimer’s Disease Mouse Model. FRONTIERS IN PHARMACOLOGY, vol. 10, pp. 910-910, ISSN:1663-9812 DOI Accesso ONLINE all'editore

Gustavo Provensi, Fabrizio Carta, Alessio Nocentini, Claudiu T. Supuran, Fiorella Casamenti, Maria Beatrice Passani, Silvia Fossati (2019). A New Kid on the Block? Carbonic Anhydrases as Possible New Targets in Alzheimer's Disease. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 20, pp. 4724-4741, ISSN:1422-0067 DOI

Ugolini, Filippo; Lana, Daniele; Nardiello, Pamela; Nosi, Daniele; Pantano, Daniela; Casamenti, Fiorella; Giovannini, Maria Grazia (2018). Different Patterns of Neurodegeneration and Glia Activation in CA1 and CA3 Hippocampal Regions of TgCRND8 Mice. FRONTIERS IN AGING NEUROSCIENCE, vol. 10, pp. 372-395, ISSN:1663-4365 DOI

Graverini, Giulia; Piazzini, Vieri; Landucci, Elisa; Pantano, Daniela; Nardiello, Pamela; Casamenti, Fiorella; PELLEGRINI-GIAMPIETRO, DOMENICO EDOARDO; Bilia, ANNA RITA; Bergonzi, MARIA CAMILLA (2018). Solid lipid nanoparticles for delivery of andrographolide across the blood-brain barrier: in vitro and in vivo evaluation.. COLLOIDS AND SURFACES. B, BIOINTERFACES, vol. 161, pp. 302-313, ISSN:0927-7765 DOI

Casamenti F., Stefani M. (2017). Olive oil polyphenols can be useful to prevent aging-associated neurodegeneration. JOURNAL OF ALZHEIMER'S, PARKINSONISM AND DEMENTIA, vol. 2, pp. 1-6, ISSN:2637-7616 Accesso ONLINE all'editore

Grossi, Cristina; Guccione, Clizia; Isacchi, Benedetta; Bergonzi, Maria Camilla; Luccarini, Ilaria; Casamenti, Fiorella; Bilia, Anna Rita (2017). Development of Blood-Brain Barrier Permeable Nanoparticles as Potential Carriers for Salvianolic Acid B to CNS. PLANTA MEDICA, vol. 83, pp. 382-391, ISSN:0032-0943 DOI Accesso ONLINE all'editore

Pantano, D; Luccarini, I; Nardiello, P; Servili, M; Stefani, M; Casamenti, F. (2017). Oleuropein aglycone and polyphenols from olive mill waste water ameliorate cognitive deficits and neuropathology. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, vol. 83, pp. 54-62, ISSN:0306-5251

Casamenti, F; Stefani, M (2017). Olive polyphenols: new promising agents to combat aging-associated neurodegeneration. EXPERT REVIEW NEUROTHERAPEUTICS, pp. 1-14, ISSN:1744-8360

Graverini, G; Piazzini, V; Landucci, E; Pantano, D; Nardiello, P; Casamenti, F; Pellegrini-Giampietro, D; Bilia Anna, R; Bergonzi Maria, C (2017). BRAIN-TARGETED DELIVERY OF ANDROGRAPHOLIDE USING SOLID LIPID NANOPARTICLES: IN VITRO AND IN VIVO EVALUATION. PLANTA MEDICA, vol. 4, pp. 0-0, ISSN:1439-0221 DOI

Annamaria, Morelli; Erica, Sarchielli; Giulia, Guarnieri; Elisabetta, Coppi; Daniela, Pantano; Paolo, Comeglio; Pamela, Nardiello; Pugliese, Anna M.; Lara, Ballerini; Rosanna, Matucci; Stefano, Ambrosini; Giuseppe, Castronovo; Rosa, Valente; Benedetta, Mazzanti; Sandra, Bucciantini; Mario, Maggi; Fiorella, Casamenti; Pasquale, Gallina; Gabriella B., Vannelli (2017). Young human cholinergic neurons respond to physiological regulators and improve cognitive symptoms in an animal model of Alzheimer’s disease. FRONTIERS IN CELLULAR NEUROSCIENCE, vol. 11:339, pp. 1-17, ISSN:1662-5102 DOI

Bergonzi, Maria C; Guccione, Clizia; Grossi, Cristina; Piazzini, Vieri; Torracchi, Andrea; Luccarini, Ilaria; Casamenti, Fiorella; Bilia, Anna R. (2016). Albumin Nanoparticles for Brain Delivery: A Comparison of Chemical versus Thermal Methods and invivo Behavior. CHEMMEDCHEM, pp. 1840-1849, ISSN:1860-7179 DOI Accesso ONLINE all'editore

Luccarini, I; Pantano, D; Nardiello, P; Cavone, L; Lapucci, A; Miceli, C; Nediani, C; Berti, A; Stefani, M; Casamenti, F (2016). The polyphenol oleuropein aglycone modulates the PARP1-SIRT1 interplay: an in vitro and in vivo study. JOURNAL OF ALZHEIMER'S DISEASE, vol. 54, pp. 0-0, ISSN:1387-2877 DOI

Elisabetta Bigagli; Cristina Luceri; Tania Scartabelli; Piero Dolara; Fiorella Casamenti; Domenico E. Pellegrini-Giampietro; Lisa Giovannelli (2016). Long-term neuro-glial co-cultures as a brain aging model: hallmarks of senescence, miRNA expression profiles and comparison with in vivo models. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, vol. 71, pp. 50-60, ISSN:1079-5006 DOI

Luccarini I; Grossi C; Rigacci S; Coppi E; Pugliese A.M.; Pantano D.; la Marca G; Ed Dami T; Berti A.; Stefani M.; Casamenti F (2015). Oleuropein aglycone protects against pyroglutamylated-3 amyloid-ß toxicity: biochemical, epigenetic and functional correlates. NEUROBIOLOGY OF AGING, vol. 36, pp. 648-663, ISSN:0197-4580 DOI

Casamenti F; Grossi C; Rigacci S; Pantano D; Luccarini I; Stefani M. (2015). Oleuropein Aglycone: A Possible Drug against Degenerative Conditions. In Vivo Evidence of its Effectiveness against Alzheimer's Disease. JOURNAL OF ALZHEIMER'S DISEASE, vol. 45, pp. 679-688, ISSN:1875-8908 DOI

Giancarlo Pepeu; Cristina Grossi; Fiorella Casamenti (2015). The Brain Cholinergic System in Neurodegenerative Diseases. ANNUAL RESEARCH & REVIEW IN BIOLOGY, vol. 6, pp. 1-19, ISSN:2347-565X

Rigacci, Stefania; Miceli, Caterina; Nediani, Chiara; Berti, Andrea; Cascella, Roberta; Pantano, Daniela; Nardiello, Pamela; Luccarini, Ilaria; Casamenti, Fiorella; Stefani, Massimo (2015). Oleuropein aglycone induces autophagy via the AMPK/mTOR signalling pathway: A mechanistic insight. ONCOTARGET, vol. 6, pp. 35344-35357, ISSN:1949-2553 DOI Accesso ONLINE all'editore

Luccarini I; Ed Dami T; Grossi C; Rigacci S; Stefani M; Casamenti F (2014). Oleuropein aglycone counteracts Aβ42 toxicity in the rat brain. NEUROSCIENCE LETTERS, vol. 558, pp. 67-72, ISSN:0304-3940 DOI

Grossi C; Ed Dami T; Rigacci S; Stefani M ; Luccarini I; Casamenti F (2014). Employing AD animal models for translational research: focus on dietary components. NEURODEGENERATIVE DISEASES, vol. 13, pp. 131-134, ISSN:1660-2854 DOI

Casamenti Fiorella; Pepeu Giancarlo (2014). Farmaci per le malattie neurodegenerative. Milano: Ambrosiana, ISBN:978-88-08-185556

C Guccione; C Grossi; F Casamenti; B Isacchi; V Piazzini; MC Bergonzi; AR Bilia (2014). Poly(ethyl cyanoacrylate) nanoparticles for brain delivery of andrographolide. PLANTA MEDICA, pp. SL24-SL24, ISSN:0032-0943 DOI

Pepeu G.; Grossi C.; Casamenti F (2013). Neurodegeneration and the cholinergic system. EUROPEAN JOURNAL OF NEURODEGENERATIVE DISEASES, vol. 2, pp. 5-17, ISSN:2279-5855

C. Luceri, E. Bigagli, V. Pitozzi, C. Grossi, F. Casamenti, L. Giovannelli (2013). A nutrigenomics approach for the study of anti-aging interventions: olive oil phenols and the modulation of microRNA profiles in mouse brain. In: Il ruolo della RICERCA farmacologica per la CRESCITA e la SALUTE in Italia- 36° Congresso della Società Italiana di Farmacologia, Torino, 23-26 ottobre 2013, Società Italiana di Farmacologia, pp. 25-25. Accesso ONLINE all'editore

Francesca Tatini; Anna Maria Pugliese; Chiara Traini; Sandra Niccoli; Giovanna Maraula; Teresa Ed Dami; Benedetta Mannini; Tania Scartabelli; Felicita Pedata; Fiorella Casamenti; Fabrizio Chiti (2013). Amyloid-β oligomer synaptotoxicity is mimicked by oligomers of the model protein HypF-N. NEUROBIOLOGY OF AGING, vol. 34, pp. 2100-2109, ISSN:0197-4580 DOI

Roberta Cascella; Simona Conti; Francesca Tatini; Elisa Evangelisti; Tania Scartabelli; Fiorella Casamenti; Mark R. Wilson; Fabrizio Chiti; Cristina Cecchi. (2013). Extracellular chaperones prevent Aβ42-induced toxicity in rat brains. BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE, vol. 1832, pp. 1217-1226, ISSN:0925-4439

C. Grossi; S. Rigacci; S. Ambrosini; T. Ed Dami; I. Luccarini; C. Traini; P. Failli; A. Berti; F. Casamenti; M. Stefani (2013). The polyphenol oleuropein aglycone protects TgCRND8 mice against Aß plaque pathology. PLOS ONE, vol. 8, pp. 1-13, ISSN:1932-6203

Grossi C.; Ambrosini S. ; Ed Dami T.; Rigacci S.; Stefani M.; Casamenti F. (2012). Oleuropein aglycon relieves memory impairments, induces brain autophagy and reduces Aß load in the TgCRND8 mouse model of Alzheimer’s Disease. In: Congresso EPHAR, Granada, pp. 241-241.

Luccarini I; Grossi C; Traini C; Fiorentini A; Ed Dami T; Casamenti F (2012). Aβ plaque-associated glial reaction as a determinant of apoptotic neuronal death and cortical gliogenesis: a study in APP mutant mice. NEUROSCIENCE LETTERS, vol. 506, pp. 94-99, ISSN:0304-3940

M.Zampagni; D.Wright; R.Cascella; G.D'Adamio; F.Casamenti; E.Evangelisti; F.Cardona; A.Goti; B.Nacmias; S.Sorbi; G.Liguri; C.Cecchi (2012). Novel S-acyl glutathione derivatives prevent amyloid oxidative stress and cholinergic dysfunction in Alzheimer disease models. Free Radic Biol Med.. FREE RADICAL BIOLOGY & MEDICINE, vol. 52 (8), pp. 1362-1371, ISSN:0891-5849 DOI

Grossi C.; Ambrosini S. ; Ed Dami T.; Rigacci S. ;Stefani M.; Casamenti F. (2012). Oleuropein aglycon relieves memory impairments, induces brain autophagy and reduces Aß load in the TgCRND8 mouse model of Alzheimer’s Disease. In: Congresso, pp. 241-241.

Zampagni M; Cascella R; Casamenti F; Grossi C; Evangelisti E; Wright D; Becatti M; Liguri G; Mannini B; Campioni S; Chiti F; Cecchi C. (2011). A comparison of the biochemical modifications caused by toxic and non-toxic protein oligomers in cells. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. 15, pp. 2106-2116, ISSN:1582-1838 DOI

Ed Dami T; Fiorentini A; Luccarini I; Traini C; Grossi C; Casamenti F. (2011). Adult hippocampal neurogenesis and cortical gliogenesis in APP mutant mice. In: Congresso IBRO, Firenze, pp. 381-381.

Tatini F; Pugliese AM; Traini C; Niccoli S; Maraula G; EdDami T; Mannini B; Pedata F; Casamenti F; Chiti F. (2011). Misfolded protein oligomers formed by a model protein mimic the effect of a-beta oligomers on synaptic plasticity involved in Alzheimer's disease. THE FEBS JOURNAL, vol. 278, pp. 481-482, ISSN:1742-4658

Rosi MC; Luccarini I; Grossi C; Fiorentini A; Spillantini MG; Prisco A; Scali C; Gianfriddo M; Caricasole A; Terstappen GC; Casamenti F. (2010). Increased Dickkopf-1 expression in transgenic mouse models of neurodegenerative disease.. JOURNAL OF NEUROCHEMISTRY, vol. 112, pp. 1539-1551, ISSN:0022-3042

A. Fiorentini; M.C. Rosi; C. Grossi; I. Luccarini; F. Casamenti (2010). Lithium Improves Hippocampal Neurogenesis,Neuropathology and Cognitive Functions in APP MutantMice. PLOS ONE, vol. 5(12): e14382, pp. 1-19, ISSN:1932-6203

Grossi C; Francese S; Casini A; Rosi MC; Luccarini I; Fiorentini A; Messori L; Moneti G; Casamenti F (2009). Clioquinol reduces Aβ plaque load and glia reaction and improves cognitive deficits in an APP transgenic mouse model. In: Congresso AD/PD, Praga, pp. 1052-1052.

Rosi MC; Fiorentini A; Grossi C; Luccarini I; Casamenti F (2009). Inhibition of GSK-3β by lithium improves amyloid pathology and learning and memory functions in a human APP transgenic mouse model. In: Congresso AD/PD, Praga, pp. 1276-1276.

Casamenti F.; Rosi MC; Grossi C.; Luccarini I.; Fiorentini A. (2009). Employing AD animal models for effective translational research. In: Congresso SINS, MILANO, pp. 57-57.

C. Grossi;S. Francese;A. Casini;M. C. Rosi;I. Luccarini;A. Fiorentini;C. Gabbiani;L. Messori;G. Moneti;F. Casamenti (2009). Clioquinol decreases amyloid-beta burden and reduces working memory impairment in a transgenic mouse model of Alzheimer's disease.. JOURNAL OF ALZHEIMER'S DISEASE, vol. 17, pp. 423-440, ISSN:1387-2877 DOI Accesso ONLINE all'editore

Rosi M.C.; Fiorentini A.; Luccarini I.; Grossi C.;Casamenti F (2008). Chronic lithium chloride treatment is effective in reducing Aβ burden and cognitive impairments in the TgCRND8 mouse model of AD.. In: Congresso ICAD, Chicago, pp. 5-5.

ESPOSITO M; LUCCARINI I; CICATIELLO V; DE FALCO D; FIORENTINI A; BARBA P; F. CASAMENTI; PRISCO A (2008). Immunogenicity and therapeutic efficacy of phage-displayed beta-amyloid epitopes. MOLECULAR IMMUNOLOGY, vol. 45, pp. 1056-1062, ISSN:0161-5890

I. Luccarini; C. Ballerini; T. Biagioli; F. Biamonti; A. Bellucci; MC. Rosi; C. Grossi; L. Massacesi; F. Casamenti (2008). Combined treatment with atorvastatin and minocycline suppresses severity of EAE. EXPERIMENTAL NEUROLOGY, vol. 211, pp. 214-226, ISSN:0014-4886 DOI

Giovannini, MG; Cerbai, F; Bellucci, A; Melani, C; Grossi, C; Bartolozzi, C; Nosi, D; Casamenti, F (2008). Differential activation of mitogen-activated protein kinase signalling pathways in the hippocampus of CRND8 transgenic mouse, a model of Alzheimer's disease. NEUROSCIENCE, vol. 153, pp. 618-633, ISSN:0306-4522 DOI

G.Pollio; JJ.Hoozemans; CA.Andersen ; R.Roncarati; MC.Rosi; ES.van Haastert ; T.Seredenina; D.Diamanti; S.Gotta; A. Fiorentini; L. Magnoni; R.Raggiaschi; AJ.Rozemuller; F.Casamenti; A.Caricasole; GC.Terstappen (2008). Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Aß toxicity. NEUROBIOLOGY OF DISEASE, vol. 31, pp. 145-158, ISSN:0969-9961

M.G. GIOVANNINI; C. SCALI; A. BELLUCCI; G. PEPEU; F. CASAMENTI (2007). NSAIDs in animal models of Alzheimer’s Disease.. In: Frank Columbus. Alzheimer’s Disease – 100 Years of Research: A Historical PerAlzheimer's Disease Research Journal, pp. 139-164, Happauge, New York: Nova Publishers.

Gulino R; Cataudella T; Casamenti F; Pepeu G; Stanzani S; Leanza G. (2007). Acetylcholine release from fetal tissue homotopically grafted to the motoneuron-depleted lumbar spinal cord. An in vivo microdialysis study in the awake rat.. EXPERIMENTAL NEUROLOGY, vol. 204, pp. 326-338, ISSN:0014-4886

A.Bellucci; MC.Rosi; C.Grossi;A.Fiorentini;I.Luccarini;F.Casamenti (2007). Abnormal processing of tau in the brain of aged TgCRND8 mice. NEUROBIOLOGY OF DISEASE, vol. 27, pp. 328-338, ISSN:0969-9961

Grossi C.; Luccarini I.; Rosi MC.; Bellucci A.; Fiorentini A. ; Casamenti F. (2006). Cholinergic dysfunction, neuronal damage and axonal loss in TGCRND8 mice.. In: ICAD, Madrid, 16-20 luglio, pp. 75-75.

S. BAGLIONI; F. CASAMENTI; M. BUCCIANTINI; L.M. LUHESHI; N. TADDEI; F. CHITI ; C.M. DOBSON; M. STEFANI (2006). Prefibrillar amyloid aggregates could be generic toxins in higher organisms. THE JOURNAL OF NEUROSCIENCE, vol. 26, pp. 8160-8167, ISSN:0270-6474 DOI

Rosi MC.; Grossi C.; Luccarini I.; Fiorentini A.; Bellucci A.; Casamenti F. (2006). Hyperphosphorylation of tau protein in the brain of a human APP transgenic mouse model. In: ICAD, Madrid, 15-20 Luglio, pp. 99-99.

BELLUCCI ARIANNA; LUCCARINI ILARIA; SCALI CARLA; PROSPERI COSTANZA; GIOVANNINI MARIA GRAZIA; PEPEU GIANCARLO; CASAMENTI FIORELLA (2006). Cholinergic dysfunction, neuronal damage and axonal loss in TgCRND8 mice. NEUROBIOLOGY OF DISEASE, vol. 23, pp. 260-272, ISSN:0969-9961, Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445: DOI

Casamenti F. ; Bellucci A. ; Rosi M. C.; Grossi C.; Luccarini I.; Fiorentini A.; Pepeu G (2006). Tau protein is hyperphosphorylated in the brain of 7-month-old TgCRND8 mice. In: FENS, Vienna, 8-12 Luglio, pp. 443-443.

Bellucci A.; Rosi M.C.; Grossi C.; Luccarini I.; Giovannini M.G.; Pepeu G.; Casamenti F. (2005). Hyperphosphorylation and deposition of tau in the brain of a human APP transgenic mouse model. In: 32nd National Congress of Italian Society of Pharmacology, SIF, pp. 117-117.

MG GIOVANNINI; M PAZZAGLI; P MALMBERG-AIELLO; L DELLA CORTE; AD RAKOVSKA; F CERBAI; F CASAMENTI; G PEPEU. (2005). Inhibition of acetylcholine-induced activation of extracellular regulated protein kinase prevents the encoding of an inhibitory avoidance response in the rat. NEUROSCIENCE, vol. 136, pp. 15-32, ISSN:0306-4522 DOI

A. BELLUCCI; M.C. ROSI; C. GROSSI; I. LUCCARINI; M.G. GIOVANNINI; G. Pepeu; F. Casamenti (2005). Tau protein is hyperphosphorylated in the brain of 7-month-old transgenic TgCRND8 mice.. In: 35th Annual Meeting of the Society for Neuroscience, Washington, DC (USA), Society for Neuroscience, pp. Program No. 83.3-Program No. 83.3.

BOYD-KIMBALL D.; FAI POON H.; LYNN B.C.; F. CASAMENTI; PEPEU G.; KLEIN J.B. AND BUTTERFIELD D.A (2005). Proteomic identification of proteins specifically oxidized by intracerebroventricular injection of Aß(1-42) into rat brain: implications for Alzheimer’s disease. NEUROSCIENCE, vol. 132, pp. 313-324, ISSN:0306-4522, Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010:

GIOVANNINI M.G.; BELLUCCI A; CERBAI F.; MELANI C.; PEPEU G.; CASAMENTI F. (2005). Activation of MAPK pathways in the brain of TgCRND8 mice. In: 35th Annual Meeting of the Society for Neuroscience, Washington, DC (USA), Society forNeuroscience, pp. Program No. 83.7-Program No. 83.7.

PROSPERI C; SCALI C; BARBA M; BELLUCCI A; M. GIOVANNINI; PEPEU G; CASAMENTI F. (2004). Comparison between flurbiprofen and its nitric oxide-releasing derivatives HCT-1026 and NCX-2216 on Abeta(1-42)-induced brain inflammation and neuronal damage in the rat. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, vol. 17, pp. 317-330, ISSN:0394-6320

G. PEPEU; A. BELLUCCI; C. PROSPERI; M.G. GIOVANNINI; F. CASAMENTI. (2004). Non-steroid antiinflammatory agents (NSAIDs): are they a valid approach to Alzheimer’s Disease prevention?. JOURNAL OF NEURAL TRANSMISSION, pp. 9-9, ISSN:0300-9564

M.G. GIOVANNINI; A. BELLUCCI; C. SCALI; F. CERBAI; G. PEPEU; F. CASAMENTI (2004). ERK and P38MAPK are differentially activated in the brain of TgCRND8 mice.. In: 34th Annual Meeting of the Society for Neuroscience, San Diego, CA (USA), Society for Neuroscience, pp. Program No. 337.20-Program No. 337.20.

A.BELLUCCI; AJ.WESTWOOD; E.INGRAM; F.CASAMENTI; M.GOEDERT; MG.SPILLANTINI (2004). Induction of inflammatory mediators and microglial activation in mice transgenic for human P301S tau protein. THE AMERICAN JOURNAL OF PATHOLOGY, vol. 165, pp. 1643-1652, ISSN:0002-9440, American Society for Investigative Pathology:9650 Rockville Pike:Bethesda, MD 20814:(301)634-7130, EMAIL: asjp@asip.org, INTERNET: http://www.asip.org, Fax: (301)634-7990:

Scali C; Giovannini MG; Prosperi C; Bellucci A; Pepeu G; Casamenti F. (2003). The selective cyclooxygenase-2 inhibitor rofecoxib suppresses brain inflammation and protects cholinergic neurons from excitotoxic degeneration in vivo.. NEUROSCIENCE, vol. 117, pp. 909-919, ISSN:0306-4522 DOI

GIOVANNINI MG; SCALI C; PROSPERI C; BELLUCCI A; PEPEU G; F. CASAMENTI (2003). Experimental brain inflammation and neurodegeneration as model of Alzheimer's disease: protective effects of selective COX-2 inhibitors.. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, vol. 16, pp. 31-40, ISSN:0394-6320

BALLMAIER M.; F. CASAMENTI; SCALI C.; MAZZONCINI R.; ZOLI M.; PEPEU G.; SPANO P.F. (2002). Rivastigmine antagonises deficits in prepulse inhibition induced by selective immunolesioning of cholinergic neurons in nucleus basalis magnocellularis. NEUROSCIENCE, vol. 114, pp. 91-98, ISSN:0306-4522

F. CASAMENTI; C. PROSPERI; C. SCALI; A. BELLUCCI; M.G. GIOVANNINI; G. PEPEU (2002). Comparison between the effects of flurbiprofen and no-flurbiprofen on brain inflammatory reaction to intracerebral -amyloid (A) injection.. In: 32nd Annual Meeting of the Society for Neuroscience, pp. Program No. 784.6.-Program No. 784.6..

Giovannini MG; Scali C; Prosperi C; Bellucci A; Vannucchi MG; Rosi S; Pepeu G; Casamenti F. (2002). Beta-amyloid-induced inflammation and cholinergic hypofunction in the rat brain in vivo: involvement of the p38MAPK pathway. NEUROBIOLOGY OF DISEASE, vol. 11, pp. 257-274, ISSN:0969-9961 DOI

SCALI C; PROSPERI C; BRACCO L; PICCINI C; BARONTI R; GINESTRONI A; SORBI S; G. PEPEU; CASAMENTI F (2002). Neutrophils CD11b and fibroblasts PGE2 are elevated in Alzheimer's disease. NEUROBIOLOGY OF AGING, vol. 23, pp. 523-530, ISSN:0197-4580 Accesso ONLINE all'editore

Scali C; Casamenti F; Bellucci A; Costagli C; Schmidt B; Pepeu G. (2002). Effect of subchronic administration of metrifonate, rivastigmine and donepezil on brain acetylcholine in aged F344 rats.. JOURNAL OF NEURAL TRANSMISSION, vol. 109, pp. 1067-1080, ISSN:0300-9564

Casamenti F.; Scali C.; Prosperi C.; Giovannini M. G.; Bellucci A.; Pepeu G. (2002). Inhibition of brain inflammatory response to quisqualic acid injection by NSAIDs in the rat. In: 3rd Forum of European Neuroscience, Paris, FENS, pp. 151-151.

ISHIMARU H.; F. CASAMENTI; UEDA K.; MARUYAMA Y.; PEPEU G. (2001). Changes in presynaptic proteins, SNAP-25 and synaptophysin, in the hippocampal CA1 area in ischemic gerbils.. BRAIN RESEARCH, vol. 903, pp. 94-101, ISSN:0006-8993

Ballmaier M; Casamenti F; Zoli M; Pepeu G; Spano P. (2001). Selective immunolesioning of cholinergic neurons in nucleus basalis magnocellularis impairs prepulse inhibition of acoustic startle.. NEUROSCIENCE, vol. 108, pp. 299-305, ISSN:0306-4522

PROSPERI C; SCALI C; G. PEPEU; CASAMENTI F (2001). NO-flurbiprofen attenuates excitotoxin-induced brain inflammation, and releases nitric oxide in the brain. JAPANESE JOURNAL OF PHARMACOLOGY, vol. 86, pp. 230-235, ISSN:0021-5198

M.G. GIOVANNINI; C. SCALI; S. ROSI; M.G. VANNUCCHI; C. PROSPERI; G. PEPEU; F. CASAMENTI (2001). The p38 MAPK pathway is activated in a model of neurodegeneration in the rat in vivo. In: 31st Annual Meeting of the Society for Neuroscience, S. Diego, CA (USA), Society for Neuroscience,, vol. Neuroscience 2001 Abstract, pp. 964.15-964.15.

F. CASAMENTI; C. SCALI; M.G. GIOVANNINI; G. PEPEU. (2001). Brain inflammatory response to ß-amyloid peptide (Aß(1-42)): effect of a selective cyclooxygenase-2-(COX-2) inhitor.. JOURNAL OF NEUROCHEMISTRY, vol. 76, suppl 1, pp. 10-10, ISSN:0022-3042

GIOVANNINI, Maria Grazia; SCALI, C; ROSI, S; VANNUCCHI, MG; PROSPERI, C; PEPEU, G; CASAMENTI, F (2001). Activation of the p38MAPK pathway cascade in models of neurodegenerative diseases in the rat in vivo. PHARMACOLOGICAL RESEARCH, vol. 76, suppl 1, pp. 7-7, ISSN:1043-6618

Scali C; Prosperi C; Vannucchi MG; Pepeu G; Casamenti F. (2000). Brain inflammatory reaction in an animal model of neuronal degeneration and its modulation by an anti-inflammatory drug: implication in Alzheimer's disease.. EUROPEAN JOURNAL OF NEUROSCIENCE, vol. 12, pp. 1900-1912, ISSN:0953-816X

L. Giovannelli; M. Veltri; F. Casamenti; G. Pepeu (2000). NGF treatment potentiates c-fos expression in the rat nucleus basalis upon excitotoxic lesion with quisqualic acid. BRAIN RESEARCH, vol. 853, pp. 136-141, ISSN:0006-8993

C. SCALI; F. CASAMENTI; C. PROSPERI; M.G.GIOVANNINI; G. PEPEU (2000). In vivo brain inflammatory reactions in anumal models of Alzheimer’s disease: effects of selective and nonselective COX-2 inhibitors.. In: 30th Annual Meeting of the Society for Neuroscience, Society for Neuroscience, vol. Neuroscience 2000 Abstract, pp. 763.19-763.19.

C. Scali; C. Prosperi; L. Giovannelli; L. Bianchi; G. Pepeu; F. Casamenti (1999). ß(1-40) Amyloid peptide injection into the nucleus basalis of rats induces microglia reaction and enhances cortical gamma-aminobutyric acid release in vivo. BRAIN RESEARCH, vol. 831, pp. 319-321, ISSN:0006-8993

Ceccarelli I; Casamenti F; Massafra C; Pepeu G; Scali C; Aloisi AM. (1999). Effects of novelty and pain on behavior and hippocampal extracellular ACh levels in male and female rats.. BRAIN RESEARCH, vol. 815, pp. 169-176, ISSN:0006-8993

F. Casamenti; C. Prosperi; C. Scali; L. Giovannelli; M.A. Colivicchi; M.S. Faussone-Pellegrini; G. Pepeu (1999). Interleukin-1 beta activates forebrain glial cells and increases nitric oxide production and cortical glutamate and GABA release in vivo: implications for Alzheimer's disease. NEUROSCIENCE, vol. 91, pp. 831-842, ISSN:0306-4522

Giovannelli, Lisa; Casamenti, Fiorella; Pepeu, Giancarlo (1998). C-fos expression in the rat nucleus basalis upon excitotoxic lesion with quisqualic acid: a study in adult and aged animals. JOURNAL OF NEURAL TRANSMISSION, vol. 105, pp. 935-948, ISSN:0300-9564

L. Giovannelli; C. Scali; M.S. Faussone-Pellegrini; G. Pepeu; F. Casamenti (1998). Long-term changes in the aggregation state and toxic effects of ß-amyloid injected into the rat brain. NEUROSCIENCE, vol. 87, pp. 349-357, ISSN:0306-4522

Casamenti, Fiorella; Prosperi, C.; Scali, C.; Giovannelli, Lisa; Pepeu, Giancarlo (1998). Morphological, biochemical and behavioural changes induced by neurotoxic and inflammatory insults to the nucleus basalis. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, vol. 16, pp. 705-714, ISSN:0736-5748

AVIGNONE E; MOLNAR M; BERRETTA N; F. CASAMENTI; PROSPERI C; RUBERTI F; CATTANEO A; CHERUBINI E (1998). Cholinergic function in the hippocampus of juvenile rats chronically deprived of NGF. BRAIN RESEARCH. DEVELOPMENTAL BRAIN RESEARCH., vol. 109, pp. 137-147, ISSN:0165-3806

C. GHELARDINI; F. GUALTIERI; M. ROMANELLI; P. ANGELI; G. PEPEU; M. GIOVANNINI; F. CASAMENTI; P. MALMBERG; A. GIOTTI; A. BARTOLINI (1997). STEREOSELECTIVE INCREASE IN CHOLINERGIC TRANSMISSION BY R-(+)- HYOSCYAMINE. NEUROPHARMACOLOGY, vol. 36, pp. 281-294, ISSN:0028-3908 DOI

Siciliano R; Fontanesi G; Casamenti F; N. BERARDI; Bagnoli P; Domenici L. (1997). Postnatal development of functional properties of visual cortical cells in rats with excitotoxic lesions of basal forebrain cholinergic neurons.. VISUAL NEUROSCIENCE, vol. 14, pp. 111-123, ISSN:0952-5238

M. VANNUCCHI; SCALI C; KOPF SR; PEPEU G; CASAMENTI F. (1997). Selective muscarinic antagonists differentially affect in vivo acetylcholine release and memory performances of young and aged rats.. NEUROSCIENCE, vol. 79, pp. 837-846, ISSN:0306-4522 Accesso ONLINE all'editore

ALOISI AM; CASAMENTI F. ; SCALI C; PEPEU G; CARLI G (1997). Effect of novelty, pain and stress on hippocampal extracellular acetylcholine levels in male rats. BRAIN RESEARCH, vol. 748, pp. 219-226, ISSN:0006-8993

BIGNAMI F; BEVILACQUA P; BIAGIONI S; DE JACO A; F. CASAMENTI; FELSANI A.; AUGUSTI-TOCCO G (1997). Cellular acetylcholine content and neuronal differentiation. JOURNAL OF NEUROCHEMISTRY, vol. 69, pp. 1374-1381, ISSN:0022-3042

GIOVANNINI MG; CASAMENTI F.; BARTOLINI L; PEPEU G (1997). The brain cholinergic system as a target of cognition enhancers. BEHAVIOURAL BRAIN RESEARCH, vol. 83, pp. 1-5, ISSN:0166-4328 DOI

G. Pepeu; L. Giovannelli; F. Casamenti; C. Scali (1996). Effects of beta-amyloid (1-40) peptide injection in the nucleus basalis.. In: R. Becker, E. Giacobini. Alzheimer Disease: From Molecular Biology to Therapy, pp. 81-85, Boston, MA, USA: Birkhauser.

ORSETTI M.; CASAMENTI F.; PEPEU G. (1996). Enhanced acetylcholine release in the hippocampus and cortex during acquisition of an operant behavior. BRAIN RESEARCH, vol. 724, pp. 89-96, ISSN:0006-8993

G. Pepeu; L. Giovannelli; F. Casamenti; C. Scali; L. Bartolini (1996). Amyloid ß-peptides injection into the cholinergic nuclei: Morphological, neurochemical and behavioral effects. Progress in Brain Research, vol. 109, pp. 273-282

Bartolini L; Casamenti F; Pepeu G. (1996). Aniracetam restores object recognition impaired by age, scopolamine, and nucleus basalis lesions.. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, vol. 53, pp. 277-283, ISSN:0091-3057

C. Ghelardini; N. Galeotti; F. Casamenti; P. Malmberg-Aiello; G. Pepeu; F. Gualtieri; A. Bartolini (1996). Central cholinergic antinociception induced by 5HT4 agonists: BIMU 1 and BIMU 8. LIFE SCIENCES, vol. 58, pp. 2297-2309, ISSN:0024-3205 DOI

C. Scali; MG Vannucchi; G. Pepeu; F. Casamenti (1995). Peripherally injected scopolamine differentially modulates acetylcholine release in vivo in the young and aged rats.. NEUROSCIENCE LETTERS, vol. 197, pp. 171-174, ISSN:0304-3940

L. Giovannelli; F. Casamenti; C. Scali; L. Bartolini; G. Pepeu (1995). Differential effects of amyloid peptides ß-(1-40) and ß-( 25-35) injections into the rat nucleus basalis. NEUROSCIENCE, vol. 66, pp. 781-792, ISSN:0306-4522

E. Abe; F. Casamenti; L. Giovannelli; C. Scali; G. Pepeu. (1994). Administration of amyloid ß-peptides into the medial septum of rats decreases acetylcholine release from hippocampus "in vivo". BRAIN RESEARCH, vol. 636, pp. 162-164, ISSN:0006-8993

Scali C; Casamenti F; Pazzagli M; Bartolini L; Pepeu G. (1994). Nerve growth factor increases extracellular acetylcholine levels in the parietal cortex and hippocampus of aged rats and restores object recognition.. NEUROSCIENCE LETTERS, vol. 170, pp. 117-120, ISSN:0304-3940

Casamenti, Fiorella; Scali, C.; Giovannelli, Lisa; Pellegrini, M.; Pepeu, G. (1994). Effect of nerve growth factor and GM1 ganglioside on the recovery of cholinergic neurons after a lesion of the nucleus basalis in aging rats. JOURNAL OF NEURAL TRANSMISSION, vol. 7, pp. 177-193, ISSN:0300-9564

Pepeu G; Oderfeld-Nowak B; Casamenti F. (1994). CNS pharmacology of gangliosides.. Progress in Brain Research, vol. 101, pp. 327-335

PEPEU G.; PAZZAGLI M.; SCALI C.; PUGLIESE A.M.; CASAMENTI; F. (1993). Metodi per lo studio "in vitro" ed "in vivo" della liberazione di acetilcolina e colina da diverse regioni cerebrali di ratto. In: Consorzio Italiano Tecnologie Farmaci Invecchiamento a cura di Angelucci L., Bernardi G., Galbiati E., Longo V., Pepeu G., Racagni G.. Metodi di Neurobiologia, pp. 1-6, Roma: Il Pensiero Scientifico Editore, ISBN:8870026000.

Zupan G; Casamenti F; Scali C; Pepeu G. (1993). Lesions of the nucleus basalis magnocellularis in immature rats: short- and long-term biochemical and behavioral changes.. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, vol. 45, pp. 19-25, ISSN:0091-3057

Pepeu G; Casamenti F; Pepeu IM; Scali C. (1993). The brain cholinergic system in ageing mammals.. JOURNAL OF REPRODUCTION AND FERTILITY. SUPPLEMENT, vol. 46, pp. 155-162, ISSN:0449-3087

Pepeu G; Casamenti F; Scali C; Jeglinski W (1993). Effect of serine phospolipids on memory and brain cholinergic mechanisms in aging rats. NEUROSCIENCE RESEARCH COMMUNICATIONS, vol. 13, pp. 63-66, ISSN:0893-6609

Oderfeld-Nowak B; Casamenti F; Pepeu G. (1993). Gangliosides in the repair of brain cholinergic neurons.. ACTA BIOCHIMICA POLONICA, vol. 40, pp. 395-404, ISSN:0001-527X

Casamenti F.; Scali C.; Vannucchi M.G.; Bartolini L.; Pepeu G (1993). Long-term ethanol consumption by rats: effect on acetylcholine release in vivo, choline acetyltransferase activity, and behavior.. NEUROSCIENCE, vol. 56, pp. 465-471, ISSN:0306-4522

Pepeu G; Casamenti F; Scali C; Jeglinski W. (1992). Aging of brain cholinergic neurons: pharmacological interventions.. CLINICAL NEUROPHARMACOLOGY, vol. 15 Suppl 1, pp. 31A-32A, ISSN:0362-5664

G. PEPEU; M.G. GIOVANNINI; F. CASAMENTI; C. SCALI; P. RODINÒ (1991). Activation of brain cholinergic system by noncholinomimetic agents. In: R. Becker and E. Giacobini. Cholinergic Basis for Alzheimer Therapy, pp. 200-205, Boston: BIRKHÄUSER.

Giovannini MG; Casamenti F; Nistri A; Paoli F; Pepeu G. (1991). Effect of thyrotropin releasing hormone (TRH) on acetylcholine release from different brain areas investigated by microdialysis.. BRITISH JOURNAL OF PHARMACOLOGY, vol. 102, pp. 363-368, ISSN:0007-1188

G. PEPEU; F. CASAMENTI; M.G. GIOVANNINI; M.G. VANNUCCHI; F. PEDATA (1991). Principal aspects of the regulation of acetylcholine release in the brain. In: S.M. Aquilonius and P.G. Gillberg. Progress in Brain Research, Vol. 84, pp. 273-278, Amsterdam: Elsevier Science.

Casamenti F; Scali C; Pepeu G. (1991). Phosphatidylserine reverses the age-dependent decrease in cortical acetylcholine release: a microdialysis study.. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 194, pp. 11-16, ISSN:0014-2999

Casamenti F; Milan F; Pepeu G. (1990). Lesions of the nucleus basalis magnocellularis in the rat: morphological, biochemical and behavioral reparative effect of nerve growth factor and ganglioside GM1.. ACTA NEUROBIOLOGIAE EXPERIMENTALIS, vol. 50, pp. 461-473, ISSN:0065-1400

M.G. GIOVANNINI; F. CASAMENTI; G. PEPEU. (1990). Cortical and hippocampal ACh release is enhanced by thyrotropin releasing hormone (TRH) in vivo.. PHARMACOLOGICAL RESEARCH, vol. 22, Suppl. 2, pp. 233-233, ISSN:1043-6618

Pepeu G; Pepeu IM; Casamenti F. (1990). The validity of animal models in the search for drugs for the aging brain.. DRUG DESIGN AND DELIVERY, vol. 7, pp. 1-10, ISSN:0884-2884

Pepeu G; Casamenti F; Giovannini MG; Vannucchi MG; Pedata F (1990). Principal aspects of the regulation of acetylcholine release in the brain.. In: Aquilonius SM, Gillberg PG. Progress in Brain Research, Vol 84, pp. 273-278, Amsterdam: Elsevier Science.

M.G. GIOVANNINI; F. CASAMENTI; C. SCALI; G. PEPEU. (1990). Transversal microdialysis for the investigation of brain cholinergic mechanisms. NEUROSCIENCE LETTERS, vol. S39, pp. 106-106, ISSN:0304-3940

Vannucchi MG; Casamenti F; Pepeu G (1990). Decrease of acetylcholine release from cortical slices in aged rats: investigations into its reversal by phosphatidylserine.. JOURNAL OF NEUROCHEMISTRY, vol. 55, pp. 819-825, ISSN:0022-3042

PEPEU G.; VANNUCCHI M. ; CASAMENTI F. (1990). Preclinical pharmacology of phosphatidylserine. CLINICAL NEUROPHARMACOLOGY, vol. 13 suppl, pp. 492-493, ISSN:0362-5664 Accesso ONLINE all'editore

G. PEPEU; F. CASAMENTI; M.G. GIOVANNINI; M.G. VANNUCCHI (1989). Microdialysis investigations of acetylcholine release: drug effects on aging rats.. In: H. Kewitz, T. Thomsen and U. Bickel. Pharmacological Interventions on Central Cholinergic Mechanisms in Senile Dementia (Alzheimer’s Type), pp. 162-167, Munchen: W. Zuckshwerdt Verlag.

Casamenti F; Di Patre PL; Milan F; Petrelli L; Pepeu G. (1989). Effects of nerve growth factor and GM1 ganglioside on the number and size of cholinergic neurons in rats with unilateral lesion of the nucleus basalis.. NEUROSCIENCE LETTERS, vol. 103, pp. 87-91, ISSN:0304-3940

Di Patre PL; Casamenti F; Cenni A; Pepeu G. (1989). Interaction between nerve growth factor and GM1 monosialoganglioside in preventing cortical choline acetyltransferase and high affinity choline uptake decrease after lesion of the nucleus basalis.. BRAIN RESEARCH, vol. 480, pp. 219-224, ISSN:0006-8993

F. CASAMENTI; M.G. GIOVANNINI; G. PEPEU. (1989). Acetylcholine release in freely moving rats by means of transversal dialysis coupled to an HPLC with electrochemical detection. JOURNAL OF NEUROSCIENCE METHODS, vol. 29, pp. 291-291, ISSN:0165-0270

Casamenti F; Di Patre PL; Bartolini L; Pepeu G. (1988). Unilateral and bilateral nucleus basalis lesions: differences in neurochemical and behavioural recovery.. NEUROSCIENCE, vol. 24, pp. 209-215, ISSN:0306-4522

Orzi F; Diana G; Casamenti F; Palombo E; Fieschi C. (1988). Local cerebral glucose utilization following unilateral and bilateral lesions of the nucleus basalis magnocellularis in the rat.. BRAIN RESEARCH, vol. 462, pp. 99-103, ISSN:0006-8993

Pepeu G.; Casamenti F.; Vannucchi M.G.; P.L. Di Patre. (1987). Cholinergic impairment in the aging brain: investigations on animal models.. In: vari. New perspective in pharmacological sciences., pp. 135-136, Firenze: Italian Pharmacol. Soc..

Florian A; Casamenti F; Pepeu G. (1987). Recovery of cortical acetylcholine output after ganglioside treatment in rats with lesion of the nucleus basalis.. NEUROSCIENCE LETTERS, vol. 75, pp. 313-316, ISSN:0304-3940

Magnani M; Florian A; Casamenti F; Pepeu G. (1987). An analysis of cholecystokinin-induced increase in acetylcholine output from cerebral cortex of the rat.. NEUROPHARMACOLOGY, vol. 26, pp. 1207-1210, ISSN:0028-3908

Casamenti F.; Bracco L.; Pedata F.; Pepeu G. (1986). Biochemical and behavioral effects of ethylcoline mustard aziridinium ion. In: Hanin I.. Dynamics of cholinergic function, pp. 43-50, New York: Ed., Advances Behav. Biol., Plenum Press.

Casamenti F; Cosi C; Pepeu G. (1986). Effect of BM-5, a presynaptic antagonist-postsynaptic agonist, on cortical acetylcholine release.. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 122, pp. 288-290, ISSN:0014-2999

Pepeu G.; Casamenti F.; Pedata F.; Orsi F.; Diana G.; Palumbo E. (1986). Neurochemical and behavioural effects following lesions of the nucleus basalis in the rat.. In: Brieley M., Kato A., Weber M.. New concepts in Alzheimer Disease., pp. 53-62, London: Mac Millan Press LTD.

Casamenti F; Deffenu G; Abbamondi AL; Pepeu G. (1986). Changes in cortical acetylcholine output induced by modulation of the nucleus basalis.. BRAIN RESEARCH BULLETIN, vol. 16, pp. 689-695, ISSN:0361-9230

Pepeu G.; Casamenti F.; Pedata F.; Bartolini L. (1986). Usefulness, constrains and limits of animal investigations in the study of aging brain and senile dementia.. In: Colloque Inserne-Eurage. Modern trends in aging research., pp. 487-494, Paris: John Libbey Eurotext Ltd.

G. PEPEU; F. CASAMENTI; F. PEDATA; C. CORSI; I. PEPEU (1986). ARE THE NEUROCHEMICAL AND BEHAVIORAL CHANGES INDUCED BY LESIONS OF THE NUCLEUS BASALIS IN THE RAT A MODEL OF ALZHEIMER'S DISEASE?. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, vol. 10, pp. 541-551, ISSN:0278-5846

Casamenti F; Bracco L; Bartolini L; Pepeu G. (1985). Effects of ganglioside treatment in rats with a lesion of the cholinergic forebrain nuclei.. BRAIN RESEARCH, vol. 338, pp. 45-52, ISSN:0006-8993

Lo Conte G; Casamenti F; Bigl V; Milaneschi E; Pepeu G. (1982). Effect of magnocellular forebrain nuclei lesions on acetylcholine output from the cerebral cortex, electrocorticogram and behaviour.. ARCHIVES ITALIENNES DE BIOLOGIE, vol. 120, pp. 176-188, ISSN:0003-9829

Lo Conte G; Bartolini L; Casamenti F; Marconcini-Pepeu I; Pepeu G. (1982). Lesions of cholinergic forebrain nuclei: changes in avoidance behavior and scopolamine actions.. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, vol. 17, pp. 933-937, ISSN:0091-3057

F. CASAMENTI ; R. CORRADETTI; K. LÖFFELHOLZ ; P. MANTOVANI; G. PEPEU (1982). Effects of 4-aminopyridine on acetylcholine output from the cerebral cortex of the rat in vivo.. BRITISH JOURNAL OF PHARMACOLOGY, vol. 76, pp. 439-445, ISSN:0007-1188

Moroni F; Corradetti R; Casamenti F; Moneti G; Pepeu G. (1981). The release of GABA and glutamate from the cerebral cortex is an index of the activity of underlying aminoacidergic neurons.. ADVANCES IN BIOCHEMICAL PSYCHOPHARMACOLOGY, vol. 27, pp. 157-167, ISSN:0065-2229

F. MORONI; R. CORRADETTI; F. CASAMENTI; G. MONETI; G. PEPEU (1981). The release of endogenous GABA and glutamate from the cerebral cortex in the rat.. NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY, vol. 316, pp. 235-239, ISSN:0028-1298

Casamenti F.; Pedata F.; Sorbi S.; Lo Conte G.; Pepeu G. (1981). Lesions of the globus pallidus: changes in cortical choline acetyltransferase, choline uptake and acetylcholine output in the rat.. In: Pepeu G. and Ladinsky H.. Cholinergic mechanisms., pp. 685-694, New York: Pepeu G. and Ladinsky H. Eds., Plenum Press.

F. CASAMENTI; F. PEDATA; R. CORRADETTI; G. PEPEU (1980). Acetylcholine output from the cerebral cortex, choline uptake and muscarinic receptors in morphine dependent freely-moving rats.. NEUROPHARMACOLOGY, vol. 19, pp. 597-605, ISSN:0028-3908

Casamenti F; Bianchi C; Beani L; Pepeu G. (1980). Effect of haloperidol and pimozide on acetylcholine output from the cerebral cortex in rats and guinea pigs.. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 65, pp. 279-284, ISSN:0014-2999

Moroni F; Casamenti F; Caliari S; Pisani G; Moneti G; Pepeu G. (1980). Acetylcholine and amino acid neurotransmitters in epidural cups of freely moving rats: effect of acute and chronic treatment with antischizophrenic drugs.. ADVANCES IN BIOCHEMICAL PSYCHOPHARMACOLOGY, vol. 24, pp. 245-252, ISSN:0065-2229

Casamenti F; Mantovani P; Amaducci L; Pepeu G. (1979). Effect of phosphatidylserine on acetylcholine output from the cerebral cortex of the rat.. JOURNAL OF NEUROCHEMISTRY, vol. 32, pp. 529-533, ISSN:0022-3042

Pepeu G.; Casamenti F.; Pedata F. (1978). Neurotrasmitters and opiate addiction. In: European Society of Neurochemistry, vol. Proceedings of the European Society for Neurochemistry. Neuhoff V. Ed., Weinheim New York, pp. 425-438.

Casamenti F; Mantovani P; Pepeu G. (1978). Stimulation of acetylcholine output from brain slices caused by the ionophores BrX-537A and A23187.. BRITISH JOURNAL OF PHARMACOLOGY, vol. 63, pp. 259-265, ISSN:0007-1188

Fiorella CASAMENTI

Biography

Fiorella Casamenti was born in Seggiano (GR) on May 10, 1952.

Graduated in Biological Sciences in 1976

1981-2001: she held the role of Assistant Professor at the Dept. of Pharmacology of the University of Florence, which later became Dept. of NEUROFARBA of the University of Florence.

2001-2022: she held the role of Associate Professor of Pharmacology at the Dept of NEUROFARBA of the University of Florence.

November 2022: retirement

Fiorella CASAMENTI

Curriculum

Fiorella Casamenti, Professore Associato, Bio14

1976: Graduated in Biological Sciences, University of Florence.

1981-2001: Assistant Professor of Pharmacology at the University of Florence.

2001-2022: Associate Professor of Pharmacology, Department NEUROFARBA, University of Florence.

Recipient of grants to work abroad in laboratories of Neuropharmacology.

Speaker at National and International Meetings as invited speaker and chairperson.

Reviewer for several international journals.

Member of the Societies: SIF, SINS, AIRIC, ENA and SfN.

Her scientific interests have mainly focussed on molecular, cellular and functional studies in in vivo animal models of neurodegenerative (Alzheimer dementia and FTD dementia) and inflammatory (MS) diseases.

The results of her researches are reported in 122 scientific papers published in outstanding International Journals, in more than 30 papers in international books and in more than 500 abstracts. She has collaborated with important national and international laboratories.

In 2005 she was a PI of the EC Integrated Project in the 6FP "Novel therapeutic substances for neurodegenerative disease in CNS and PNS". The application with the title "Design of small molecule therapeutics for the treatment of Alzheimer's disease based on the discovery of innovative drug targets", 5 years research project was funded by the EC.

She has been the Scientific Coordinator and National Manager of funded PRIN projects, Tuscany Region, CRF, MPS, Telethon and University of Florence research funded projects.

Teacher in the Medical Faculty of Florence, in the CDL Physiotherapy, CDL Nursing, in the Specialization Schools of Psychiatry, Neurology, Pharmacology and Neuro-physiopathology.

She has been the scientific tutor of PhD students in Pharmacology at the University of Florence.

Fiorella Casamenti is retired since November 2022

Fiorella CASAMENTI

Interest

Fiorella Casamenti, Associate Professor, BIO 14

Main areas of interest and research have been to study in animal models “in vivo” the neurodegenerative mechanisms involved in the Alzheimer’s disease (AD), Fronto Temporal dementia (FTD) and Multiple Sclerosis.

Animal models of Alzheimer’s disease. She has studied the pathogenetic aspects of AD in the transgenic CRND mouse model, carrying the human mutation of the amyloid precursor protein (APP), in rats intracerebral injected with the amyloid peptide Aß(1-42) or his fragments, with exitotoxins or bacteric proteins not associated with diseases. In these models has conducted himmunoistochemical, molecular and functional studies and has investigated the neuroprotective effects of different drugs

Animal model of FTD. She has studied the similarities between neuropathy in patients with taupathy and transgenic mice with the mutated human form of tau P301S.

Animal model of Multiple Sclerosis. In the animal model of Multiple Sclerosis (EAE) has studied the axonophaty associated to the inflammatory cascade and the protective effect of drugs, such as minocycline and statins