Daniela CATARZI

Ruolo attuale:: Professore Associato
SSD:: CHEM-07/A - Chimica farmaceutica
Afferenza organizzativa:: Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino (NEUROFARBA)

Recapiti

	0554573722
	daniela.catarzi(AT)unifi.it

Ulteriori Recapiti

0554573722

Avvisi

Corso ADE "Progettazione e sintesi dei farmaci"

Le lezioni teoriche si terranno a giugno, nei giorni 4, 5 (aula 42, edificio P5, via U.Schiff,6-Sesto F.no) e 6 (aula informatica 115, Plesso Morgagni) (9:30-13:30). Il periodo per lo stage verrà concordato successivamente. Per info: Prof. Catarzi.

Daniela CATARZI

Orario di ricevimento (aggiornato al 03/06/2013) Tutti i giorni, previo appuntamento per E-mail o telefono.

Daniela CATARZI

Biografia

1990: Laurea in Chimica e Tecnologia Farmaceutiche presso l'Università degli Studi di Firenze (110/110 e lode)
1993: Titolo di Dottore di Ricerca in Chimica del Farmaco, presso l'Università di Firenze
1995-1998: Assistente Tecnico-VI Livello, presso il Dipartimento di Scienze Farmaceutiche, Università degli Studi di Firenze
1998-2015: Ricercatore (SSD CHIM/08), Dipartimento di NEUROFARBA -Sezione di Farmaceutica e Nutraceutica (ex Dipartimento di Scienze Farmaceutiche), Università degli Studi di Firenze
Dal 2015 ad oggi: Professore di II fascia (SSD CHIM/08, oggi CHEM-07/A), Dipartimento di NEUROFARBA -Sezione di Farmaceutica e Nutraceutica (ex Dipartimento di Scienze Farmaceutiche), Università degli Studi di Firenze

Daniela CATARZI

Curriculum

L'ATTIVITA' DI RICERCA della Prof. Daniela Catarzi si svolge in ambito Chimico-Farmaceutico. I primi studi si sono concentrati sull'identificazione di ligandi del recettore benzodiazepinico e di antagonisti del recettore GABA_A. Negli ultimi anni la sua attenzione si è rivolta allo sviluppo di ligandi dei recettori adenosinici, di modulatori dell'anidrasi carbonica, e di inibitori di chinasi (CK2, CK1delta) e del CD73, che rappresentano possibili nuove strategie terapeutiche per il trattamento delle malattie neurodegenerative e del cancro. Particolare interesse è dedicato alla progettazione e sintesi di molecole ibride come agenti terapeutici innovativi per un approccio polifarmacologico.

Pubblicazioni: co-autore di 100 pubblicazioni su riviste internazionali, 1 brevetto internazionale, 44 comunicazioni a Congressi Nazionali e Internazionali; H index = 31

Titoli accademici.

1990: Laurea in Chimica e Tecnologia Farmaceutiche, 110/110 e lode;

1990-1993: Dottorato di Ricerca in Chimica del Farmaco.

Esperienze e carriera professionale.

1990: Borsa di studio, FIDIA s.p.a;

1993-94 Borsa di studio, Prof. F. Gualtieri;

1995-98: Assistente Tecnico-VI Livello (Dipartimento di Scienze Farmaceutiche, Università di Firenze).

1998-2015: Ricercatore Universitario T.P. Settore CHIM/08 (Università di Firenze, Facoltà di Farmacia, e poi Dipartimento Neurofarba, Sez. Farmaceutica e Nutraceutica).

2012: Abilitazione Scientifica Nazionale II fascia professori universitari (settore concorsuale 03/D1);

Dal 2015 ad oggi: Professore Associato (settore CHIM/08, Dipartimento Neurofarba).

Attività editoriale.

Dal 2018 ad oggi: Guest Editor rivista “Pharmaceuticals”, IF = 5.215 (Open Access Journal MDPI).

2020: membro Editorial Board della rivista Pharmaceuticals.

Attività didattica.

AA 2000-2001: Corso di Chimica Farmaceutica e Tossicologica (Corso di Diploma Universitario di Controllo di Qualità nel Settore Industriale e Farmaceutico);

AA 2001-02 e 2003-04: modulo corso di Chimica Farmaceutica e Tossicologica II (CTF);

dall'AA 1999-2000 ad oggi: Corso di Analisi dei Medicinali (CTF), in qualità di Co-docente (fino all’AA 2005-06) e dall’AA 2006-07 come Titolare.

Responsabilità accademiche:

Dal 2016 ad oggi: Delegato all’Orientamento della Scuola di Scienze della Salute Umana-Area del Farmaco.

Daniela CATARZI

Interessi

L'attività di ricerca si concentra sulla sintesi e la caratterizzazione strutturale di nuove piccole molecole progettate per interagire con specifiche proteine coinvolte in patologie ad elevato impatto sociale, e per individuare nuovi approcci terapeutici. L'attenzione è rivolta in particolare allo sviluppo di ligandi dei recettori dell'adenosina, modulatori delle anidrasi carboniche, inibitori della caseina chinasi 1δ e del CD73, che rappresentano possibili nuovi agenti terapeutici per il trattamento del cancro e di malattie neurodegenerative, quali le malattie di Alzheimer e di Parkinson, sclerosi multipla e sclerosi laterale amiotrofica.

Una parte della ricerca è dedicata alla progettazione e sintesi di molecole multitarget per esplorarne il potenziale come agenti polifarmacologici innovativi per il trattamento di patologie multifattoriali.

Particolare attenzione è rivolta a sperimentazione e implementazione di strategie green per la sintesi e la purificazione dei composti oggetto della ricerca.

Daniela CATARZI

Pubblicazioni

Legenda

Contributo su rivista |

Articolo su libro |

Libro |

Contributo in atti di convegno (proceeding) |

Brevetto |

Curatela | Altro

Altro |

Tesi di Dottorato

Calenda, Sara; Catarzi, Daniela; Varano, Flavia; Vigiani, Erica; Volpini, Rosaria; Lambertucci, Catia; Spinaci, Andrea; Trevisan, Letizia; Grieco, Ilenia; Federico, Stephanie; Spalluto, Giampiero; Novello, Gianluca; Salmaso, Veronica; Moro, Stefano; Colotta, Vittoria (2024). Structural Investigations on 2-Amidobenzimidazole Derivatives as New Inhibitors of Protein Kinase CK1 Delta. PHARMACEUTICALS, vol. 17, pp. 0-0, ISSN:1424-8247 DOI

Varano, Flavia; Catarzi, Daniela; Vigiani, Erica; Calenda, Sara; Colotta, Vittoria (2023). Adenosine Receptor Ligands as Potential Therapeutic Agents for Impaired Wound Healing and Fibrosis. In: Flavia Varano, Daniela Catarzi, Erica Vigiani, Sara Calenda, Vittoria Colotta. Purinergic Receptors and their Modulators, pp. 89-99 Springer, ISBN:978-3-031-39724-0., vol. 41: DOI

Spinaci, Andrea; Buccioni, Michela; Catarzi, Daniela; Cui, Chang; Colotta, Vittoria; Dal Ben, Diego; Cescon, Eleonora; Francucci, Beatrice; Grieco, Ilenia; Lambertucci, Catia; Marucci, Gabriella; Bassani, Davide; Pavan, Matteo; Varano, Flavia; Federico, Stephanie; Spalluto, Giampiero; Moro, Stefano; Volpini, Rosaria (2023). “Dual Anta-Inhibitors” of the A2A Adenosine Receptor and Casein Kinase CK1delta: Synthesis, Biological Evaluation, and Molecular Modeling Studies. PHARMACEUTICALS, vol. 16, pp. 0-0, ISSN:1424-8247 DOI

Venturini M.; Cherchi F.; Santalmasi C.; Frulloni L.; Dettori I.; Catarzi D.; Pedata F.; Colotta V.; Varano F.; Coppi E.; Pugliese A.M. (2023). Pharmacological Characterization of P626, a Novel Dual Adenosine A2A/A2B Receptor Antagonist, on Synaptic Plasticity and during an Ischemic-like Insult in CA1 Rat Hippocampus. BIOMOLECULES, vol. 13, pp. 0-0, ISSN:2218-273X DOI

Catarzi, Daniela; Varano, Flavia; Calenda, Sara; Vigiani, Erica; Colotta, Vittoria (2023). Once Upon a Time Adenosine and Its Receptors: Historical Survey and Perspectives as Potential Targets for Therapy in Human Diseases. In: Daniela Catarzi, Flavia Varano, Sara Calenda, Erica Vigiani, Vittoria Colotta. Purinergic Receptors and their Modulators, pp. 1-46 Springer, ISBN:978-3-031-39724-0., vol. 41: DOI

Varano, Flavia; Catarzi, Daniela; Calenda, Sara; Vigiani, Erica; Colotta, Vittoria (2022). CK1 delta inhibition: an emerging strategy to combat neurodegenerative diseases. FUTURE MEDICINAL CHEMISTRY, vol. 14, pp. 1111-1113, ISSN:1756-8919 DOI

Catarzi, Daniela; Varano, Flavia; Vigiani, Erica; Calenda, Sara; Melani, Fabrizio; Varani, Katia; Vincenzi, Fabrizio; Pasquini, Silvia; Mennini, Natascia; Nerli, Giulia; Dal Ben, Diego; Volpini, Rosaria; Colotta, Vittoria (2022). 4-Heteroaryl Substituted Amino-3,5-Dicyanopyridines as New Adenosine Receptor Ligands: Novel Insights on Structure-Activity Relationships and Perspectives. PHARMACEUTICALS, vol. 15, pp. 0-0, ISSN:1424-8247 DOI

Lambertucci, Catia; Marucci, Gabriella; Catarzi, Daniela; Colotta, Vittoria; Francucci, Beatrice; Spinaci, Andrea; Varano, Flavia; Volpini, Rosaria (2022). A2A Adenosine Receptor Antagonists and their Potential in Neurological Disorders. CURRENT MEDICINAL CHEMISTRY, vol. 29, pp. 4780-4795, ISSN:0929-8673 DOI

Catarzi, Daniela; Varano, Flavia; Vigiani, Erica; Lambertucci, Catia; Spinaci, Andrea; Volpini, Rosaria; Colotta, Vittoria (2022). Casein Kinase 1δ Inhibitors as Promising Therapeutic Agents for Neurodegenerative Disorders. CURRENT MEDICINAL CHEMISTRY, vol. 29, pp. 4698-4737, ISSN:0929-8673 DOI

Varano, Flavia; Catarzi, Daniela; Vigiani, Erica; Dal Ben, Diego; Buccioni, Michela; Marucci, Gabriella; Di Cesare Mannelli, Lorenzo; Lucarini, Elena; Ghelardini, Carla; Volpini, Rosaria; Colotta, Vittoria (2021). Design and Synthesis of Novel Thiazolo[5,4-d]pyrimidine Derivatives with High Affinity for Both the Adenosine A1 and A2A Receptors, and Efficacy in Animal Models of Depression. PHARMACEUTICALS, vol. 14, pp. 0-0, ISSN:1424-8247 DOI

Catarzi D.; Varano F.; Colotta V. (2021). Special issue “adenosine receptors as attractive targets in human diseases”. PHARMACEUTICALS, vol. 14, pp. 1-3, ISSN:1424-8247 DOI

Falsini M.; Ceni C.; Catarzi D.; Varano F.; Dal Ben D.; Marucci G.; Buccioni M.; Marti Navia A.; Volpini R.; Colotta V. (2020). New 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives. Evaluation of different moieties on the 6-aryl ring to obtain potent and selective human A2A adenosine receptor antagonists. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 30, pp. 127126-127126, ISSN:0960-894X DOI Accesso ONLINE all'editore

Varano F.; Catarzi D.; Vincenzi F.; Pasquini S.; Pelletier J.; Lopes Rangel Fietto J.; Espindola Gelsleichter N.; Sarlandie M.; Guilbaud A.; Sevigny J.; Varani K.; Colotta V. (2020). Structural investigation on thiazolo[5,4-d]pyrimidines to obtain dual-acting blockers of CD73 and adenosine A2A receptor as potential antitumor agents. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 30, pp. 127067-127067, ISSN:0960-894X DOI Accesso ONLINE all'editore

Ceni C.; Catarzi D.; Varano F.; Ben D.D.; Marucci G.; Buccioni M.; Volpini R.; Angeli A.; Nocentini A.; Gratteri P.; Supuran C.T.; Colotta V. (2020). Discovery of first-in-class multi-target adenosine A2A receptor antagonists-carbonic anhydrase IX and XII inhibitors. 8-Amino-6-aryl-2-phenyl-1,2,4-triazolo [4,3-a]pyrazin-3-one derivatives as new potential antitumor agents. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 201, pp. 0-16, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Coppi E.; Cherchi F.; Fusco I.; Dettori I.; Gaviano L.; Magni G.; Catarzi D.; Colotta V.; Varano F.; Rossi F.; Bernacchioni C.; Donati C.; Bruni P.; Pedata F.; Cencetti F.; Pugliese A.M. (2020). Adenosine A2B receptors inhibit K+ currents and cell differentiation in cultured oligodendrocyte precursor cells and modulate sphingosine-1-phosphate signaling pathway. BIOCHEMICAL PHARMACOLOGY, vol. 177, pp. 1-7, ISSN:0006-2952 DOI

Varano F.; Catarzi D.; Vigiani E.; Vincenzi F.; Pasquini S.; Varani K.; Colotta V. (2020). Piperazine-and piperidine-containing thiazolo[5,4-d]pyrimidine derivatives as new potent and selective adenosine a2a receptor inverse agonists. PHARMACEUTICALS, vol. 13, pp. 1-19, ISSN:1424-8247 DOI

Catarzi D.; Varano F.; Varani K.; Vincenzi F.; Pasquini S.; Dal Ben D.; Volpini R.; Colotta V. (2019). Amino-3, 5-dicyanopyridines targeting the adenosine receptors. Ranging from pan ligands to combined A1/A2B partial agonists. PHARMACEUTICALS, vol. 12, pp. 159-181, ISSN:1424-8247 DOI Accesso ONLINE all'editore

Falsini M.; Catarzi D.; Varano F.; Ceni C.; Dal Ben D.; Marucci G.; Buccioni M.; Volpini R.; Di Cesare Mannelli L.; Lucarini E.; Ghelardini C.; Bartolucci G.; Menicatti M.; Colotta V. (2019). Antioxidant-Conjugated 1,2,4-Triazolo[4,3-a]pyrazin-3-one Derivatives: Highly Potent and Selective Human A2A Adenosine Receptor Antagonists Possessing Protective Efficacy in Neuropathic Pain. JOURNAL OF MEDICINAL CHEMISTRY, vol. 62, pp. 8511-8531, ISSN:1520-4804 DOI

Varano, Flavia*; Catarzi, Daniela; Falsini, Matteo; Dal Ben, Diego; Buccioni, Michela; Marucci, Gabriella; Volpini, Rosaria; Colotta, Vittoria (2019). Novel human adenosine receptor antagonists based on the 7-amino-thiazolo[5,4-d]pyrimidine scaffold. Structural investigations at the 2-, 5- and 7-positions to enhance affinity and tune selectivity. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 29, pp. 563-569, ISSN:0960-894X DOI Accesso ONLINE all'editore

Varano Flavia, Catarzi Daniela, Colotta Vittoria, Borea Pier Andrea, Vincenzi Fabrizio, Varani Katia (2019). NUOVI TIAZOLO[5,4-d]PIRIMIDIN DERIVATI QUALI AGONISTI INVERSI DEI RECETTORI A2A DELL’ADENOSINA. Numero: 102016000070952 Università degli studi di Firenze 50%, Università degli studi di Ferrara 50%

Falsini, Matteo; Catarzi, Daniela; Varano, Flavia; Dal Ben, Diego; Marucci, Gabriella; Buccioni, Michela; Volpini, Rosaria; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Colotta, Vittoria* (2019). Novel 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives as potent human adenosine A 1 and A 2A receptor antagonists. Evaluation of their protective effect against β-amyloid-induced neurotoxicity in SH-SY5Y cells. BIOORGANIC CHEMISTRY, vol. 87, pp. 380-394, ISSN:0045-2068 DOI Accesso ONLINE all'editore

Fusco I.; Cherchi F.; Catarzi D.; Colotta V.; Varano F.; Pedata F.; Pugliese A.M.; Coppi E. (2019). Functional characterization of a novel adenosine A2B receptor agonist on short-term plasticity and synaptic inhibition during oxygen and glucose deprivation in the rat CA1 hippocampus. BRAIN RESEARCH BULLETIN, pp. 1-7, ISSN:0361-9230 DOI Accesso ONLINE all'editore

Betti, Marco; Catarzi, Daniela; Varano, Flavia; Falsini, Matteo; Varani, Katia; Vincenzi, Fabrizio; Pasquini, Silvia; di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Lucarini, Elena; Dal Ben, Diego; Spinaci, Andrea; Bartolucci, Gian Luca; Menicatti, Marta; Colotta, Vittoria (2019). Modifications on the Amino-3,5-dicyanopyridine Core To Obtain Multifaceted Adenosine Receptor Ligands with Antineuropathic Activity. JOURNAL OF MEDICINAL CHEMISTRY, vol. 62, pp. 6894-6912, ISSN:0022-2623 DOI

Flavia, Varano; Vittoria, Colotta; Daniela, Catarzi; Katia, Varani; Pier Andrea Borea, ; Fabrizio, Vincenzi (2018). Novel Thiazolo[4,5-d]pyrimidine derivatives as inverse agonists of A2A adenosine receptors. Numero: WO 2018/007957 Università degli Studi di Firenze, Università degli Studi di Ferrara

Varano, Flavia*; Catarzi, Daniela; Vincenzi, Fabrizio; Falsini, Matteo; Pasquini, Silvia; Borea, Pier Andrea; Colotta, Vittoria; Varani, Katia (2018). Structure-activity relationship studies and pharmacological characterization of N5-heteroarylalkyl-substituted-2-(2-furanyl)thiazolo[5,4-d]pyrimidine-5,7-diamine-based derivatives as inverse agonists at human A2Aadenosine receptor. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 155, pp. 552-561, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Bonardi, Alessandro; Falsini, Matteo; Catarzi, Daniela; Varano, Flavia; Di Cesare Mannelli, Lorenzo; Tenci, Barbara; Ghelardini, Carla; Angeli, Andrea; Supuran, Claudiu T.; Colotta, Vittoria* (2018). Structural investigations on coumarins leading to chromeno[4,3-c]pyrazol-4-ones and pyrano[4,3-c]pyrazol-4-ones: New scaffolds for the design of the tumor-associated carbonic anhydrase isoforms IX and XII. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 146, pp. 47-59, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Daniela Catarzi , Flavia Varano, Matteo Falsini , Katia Varani, Fabrizio Vincenzi , Silvia Pasquini , Diego Dal Ben, Vittoria Colotta (2018). Development of novel pyridazinone-based adenosine receptor ligands. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 28, pp. 1484-1489, ISSN:0960-894X DOI

Varano, Flavia*; Catarzi, Daniela; Falsini, Matteo; Vincenzi, Fabrizio; Pasquini, Silvia; Varani, Katia; Colotta, Vittoria (2018). Identification of novel thiazolo[5,4-d]pyrimidine derivatives as human A1and A2Aadenosine receptor antagonists/inverse agonists. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 26, pp. 3688-3695, ISSN:0968-0896 DOI Accesso ONLINE all'editore

Betti, Marco; Catarzi, Daniela; Varano, Flavia; Falsini, Matteo; Varani, Katia; Vincenzi, Fabrizio; Ben, Diego Dal; Lambertucci, Catia; Colotta, Vittoria (2018). The aminopyridine-3,5-dicarbonitrile core for the design of new non-nucleoside-like agonists of the human adenosine A2Breceptor. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 150, pp. 127-139, ISSN:0223-5234 DOI

Falsini, Matteo; Squarcialupi, Lucia; Catarzi, Daniela; Varano, Flavia; Betti, Marco; Dal Ben, Diego; Marucci, Gabriella; Buccioni, Michela; Volpini, Rosaria; De Vita, Teresa; Cavalli, Andrea; Colotta, Vittoria (2017). The 1,2,4-Triazolo[4,3-a]pyrazin-3-one as a Versatile Scaffold for the Design of Potent Adenosine Human Receptor Antagonists. Structural Investigations to Target the A2A Receptor Subtype. JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, pp. 5772-5790, ISSN:0022-2623 DOI Accesso ONLINE all'editore

Falsini, Matteo; Squarcialupi, Lucia; Catarzi, Daniela; Varano, Flavia; Betti, Marco; Di Cesare Mannelli, Lorenzo; Tenci, Barbara; Ghelardini, Carla; Tanc, Muhammet; Angeli, Andrea; Supuran, Claudiu T.; Colotta, Vittoria (2017). 3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold to Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII. JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, pp. 6428-6439, ISSN:0022-2623 DOI Accesso ONLINE all'editore

Anna Maria Pugliese, ; Irene, Fusco; Francesca, Cencetti; Ilaria, Dettori; Lisa, Gaviano; Chiara, Donati; Paola, Bruni; Daniela, Catarzi; Elisabetta, Coppi; Felicita, Pedata (2017). Activation of adenosine A 2B receptors and sphingosine kinase/sphingosine 1-phosphate signaling axis modulates the amplitude of outward K + currents and maturation of oligodendrocyte precursor cells. PURINERGIC SIGNALLING, pp. 631-632, ISSN:1573-9538 DOI

Gessi, Stefania; Bencivenni, Serena; Battistello, Enrica; Vincenzi, Fabrizio; Colotta, Vittoria; Catarzi, Daniela; Varano, Flavia; Merighi, Stefania; Borea, Pier Andrea; Varani, Katia (2017). Inhibition of A2Aadenosine receptor signaling in cancer cells proliferation by the novel antagonist TP455. FRONTIERS IN PHARMACOLOGY, vol. 8, pp. 888-888, ISSN:1663-9812 DOI Accesso ONLINE all'editore

Fabrizio, Vincenzi; Flavia, Varano; Daniela, Catarzi; Annalisa, Ravani; Enrica, Battistello; Ssilvia, Pasquini; Stefania, Gessi; Stefania, Merighi; P?ier Andrea Borea, ; Vittoria, Colotta; Katia, Varani (2017). Pharmacological characterization of new highly potent A2a adenosine receptor inverse agonissts with antinociceptive activity. In: 2017 Italian-German Purine Club Meeting, springer, pp. 666-666.

Squarcialupi, Lucia; Betti, Marco; Catarzi, Daniela; Varano, Flavia; Falsini, Matteo; Ravani, Annalisa; Pasquini, Silvia; Vincenzi, Fabrizio; Salmaso, Veronica; Sturlese, Mattia; Varani, Katia; Moro, Stefano; Colotta, Vittoria (2017). The role of 5-arylalkylamino- and 5-piperazino- moieties on the 7-aminopyrazolo[4,3-d]pyrimidine core in affecting adenosine A1 and A2A receptor affinity and selectivity profiles. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 32, pp. 248-263, ISSN:1475-6366 DOI

Daniela Poli, ; Matteo Falsini, ; Flavia Varano, ; Marco Betti, ; Katia Varani, ; Fabrizio Vincenzi, ; Anna Maria Pugliese, ; Felicita Pedata, ; Diego Dal Ben, ; Ajiroghene Thomas, ; Ilaria Palchetti, ; Francesca Bettazzi, ; Daniela Catarzi, ; Colotta, Vittoria (2017). Imidazo[1,2-a]pyrazin-8-amine core for the design of new adenosine receptor antagonists: Structural exploration to target the A3 and A2A subtypes. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 125, pp. 611-628, ISSN:1768-3254 DOI

Ilaria, Dettori; Elisabetta, Coppi; Irene, Fusco; Francesca, Cencetti; Lisa, Gaviano; Paola, Bruni; Vittoria, Colotta; Daniela, Catarzi; Felicita, Pedata; Anna Maria Pugliese, (2017). Adenosine A2B receptors stimulation inhibits oligodendrocyte maturation by interacting with sphingosine kinase/sphingosine 1-phosphate signalling axis in primary purified oligodendrocyte cultures. PURINERGIC SIGNALLING, pp. 658-659, ISSN:1573-9538 DOI

Betti, Marco; Colotta, Vittoria; Varano, Flavia; Falsini, Matteo; Varani, Katia; Vincenzi, Fabrizio; Ben, Diego Dal; Pugliese, Annamaria; Catarzi, Daniela (2016). New aminopyridine-3,5-dicarbonitirles as adenosine A2B receptor non-nucleoside agonists.. In: 33rd Camerino-Cyprus Symposium. Receptor Chemistry: reality and vision. 15-19 maggio 2016, Camerino., d, pp. 69-69.

Falsini, M.; Catarzi, D.; Varano, F.; Betti, M.; Dal Ben, D.; Marucci, G.; Buccioni, M.; Volpini, R.; De Vita, T.; Colotta, V. . (2016). 2-Aryl-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives as new potent adenosine human A2A receptor antagonists. In: XXIV National Meeting on Medicinal Chemistry, 10th Young Medicinal Chemists’ Symposium, 11-14 settembre 2016, Perugia., d, pp. 239-239.

Betti, M.; Colotta, V.; Varano, F.; Falsini, M.; Varani, K.; Vincenzi, F.; Dal Ben, D.; Di Cesare Mannelli, L.; Zanardelli, M.; Bartolucci, G.; Menicatti, M.; Catarzi, D. (2016). Aminopyridine-3,5-carbonitrile core for the design of new adenosine receptor agonists: structural exploration to target the A1 subtype. In: XXIV National Meeting on Medicinal Chemistry, 10th Young Medicinal Chemists’ Symposium, 11-14 settembre 2016, Perugia., d, pp. 108-108.

Lucia Squarcialupi; Matteo Falsini; Daniela Catarzi; Flavia Varano; Marco Betti; Katia Varani; Fabrizio Vincenzi; Diego Dal Ben; Catia Lambertucci; Rosaria Volpini; Vittoria Colotta (2016). Exploring the 2- and 5-positions of the pyrazolo[4,3-d]pyrimidin-7-amino scaffold to target human A1 and A2A adenosine receptors. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 24, pp. 2794-2808, ISSN:1464-3391

Lucia Squarcialupi ; Daniela Catarzi ; Flavia Varano; Marco Betti; Matteo Falsini; Fabrizio Vincenzi ; Annalisa Ravani; Antonella Ciancetta ; Katia Varani ; Stefano Moro; Vittoria Colotta (2016). Structural refinement of pyrazolo[4,3-d]pyrimidine derivatives to obtain highly potent and selective antagonists for the human A3 adenosine receptor. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 108, pp. 117-133, ISSN:1768-3254

Flavia Varano; Vittoria Colotta; Daniela Catarzi; Katia Varani; Pier Andrea Borea; Fabrizio Vincenzi (2016). Nuovi tiazoli[5,4-d]pirimidin derivati quali agonisti inversi dei recettori A2A dell'adenosina. Flavia Varano; Vittoria Colotta; Daniela Catarzi; Katia Varani; Pier Andrea Borea; Fabrizio Vincenzi

Flavia Varano; Daniela Catarzi; Fabrizio Vincenzi; Marco Betti; Matteo Falsini; Annalisa Ravani; Pier Andrea Borea; Vittoria Colotta; Katia Varani (2016). Design, synthesis, and pharmacological characterization of 2‑(2- furanyl)thiazolo[5,4‑d]pyrimidine-5,7-diamine derivatives: new highly potent A2A adenosine receptor inverse agonists with antinociceptive activity. JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, pp. 10564-10576, ISSN:0022-2623

Falsini, Matteo; Squarcialupi, Lucia; Catarzi, Daniela; Varano, Flavia; Betti, Marco; Varani, Katia; Vincenzi, Fabrizio; Ben, Diego Dal; Lambertucci, Catia; Volpini, Rosaria; Colotta, Vittoria (2016). New 5-heteroaryl-pyrazolo[4,3-d]pyrimidin-7-amines as dual human adenosine A1 and A2A receptor antagonists.. In: 33rd Camerino-Cyprus Symposium. Receptor Chemistry: reality and vision. 15-19 maggio 2016, Camerino., d, pp. 78-78.

Squarcialupi, L.; Falsini, M.; Catarzi, D.; Varano, F.; Betti, M.; Di Cesare Mannelli, L.; Zanardelli, M.; Ghelardini, C.; Tanc, M.; Supuran, C.T.; Colotta, V. (2015). 3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new potent and selective inhibitors of the tumor-associated carbonic anhydrase IX and XII.. In: XXIII National Meeting on Medicinal Chemistry, 6-9 settembre 2015, Salerno., d, pp. 131-131.

Betti, Marco; Catarzi, Daniela; Varano, Flavia; Varani, Katia; Lorenzo Di Cesare Mannelli, ; Zanardelli, M.; Ghelardini, Carla; Colotta, Vittoria . (2015). Aminopyridine-3,5-dicarbonitriles as non-nucleoside adenosine A1 receptor agonists.. In: XXIII National Meeting on Medicinal Chemistry, 6-9 settembre 2015, Salerno., d, pp. 132-132.

Flavia Varano; Daniela Catarzi ; Lucia Squarcialupi ; Marco Betti ; Fabrizio Vincenzi ; Annalisa Ravani ; Katia Varani ; Diego Dal Ben ; Ajiroghene Thomas ; Rosaria Volpini ; Vittoria Colotta (2015). Exploring the 7-oxo-thiazolo[5,4-d]pyrimidine core for the design of new human adenosine A3 receptor antagonists. Synthesis, molecular modeling studies and pharmacological evaluation. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, pp. 105-121, ISSN:0223-5234

Catarzi, D.; Colotta, V.; Betti, M.; Falsini, M.; Dal Ben, D.; Marucci, G.; Buccioni, M.; Varano, F. (2015). Thiazolo[5,4-d]pyrimidin-7-amino derivatives as dual human adenosine A2A/A1 receptor antagonists.. In: XXIII National Meeting on Medicinal Chemistry, 6-9 settembre 2015, Salerno., d, pp. 171-171.

Daniela Catarzi ; Flavia Varano; Daniela Poli ; Lucia Squarcialupi; Marco Betti ; Letizia Trincavelli; Claudia Martini ; Diego Dal Ben ; Ajiroghene Thomas ; Rosaria Volpini ; Vittoria Colotta (2015). 1,2,4-Triazolo[1,5-a]quinoxaline derivatives and their simplified analogues as adenosine A3 receptor antagonists. Synthesis, structure–affinity relationships and molecular modeling studies. BIOORGANIC & MEDICINAL CHEMISTRY, pp. 9-21, ISSN:1464-3391

V. Colotta; L. Squarcialupi; D. Catarzi; F. Varano; R. Volpini; M. Buccioni; D. Dal Ben. (2014). 1,2,4-Triazolo[4,3-a]pyrazin-3-one as a new scaffold to develop potent adenosine receptor antagonists. In: XXV Congresso Nazionale della Società Chimica Italiana, Arcavacata di Rende (CS), 07-12 settembre 2014, d, pp. 350-350.

Flavia Varano; Daniela Catarzi; Vittoria Colotta; Lucia Squarcialupi; Rosanna Matucci (2014). 1,2,4-Benzothiadiazine-1,1-dioxide Derivatives as Ionotropic Glutamate Receptor Ligands: Synthesis and Structure–Activity Relationships. ARCHIV DER PHARMAZIE, pp. 777-785, ISSN:0365-6233 DOI

F. Varano; D. Catarzi; V. Colotta; L. Squarcialupi K. Varani; D. Dal Ben (2014). Exploring the 7-oxo-thiazolo[5,4-d]pyrimidine scaffold for the design of new adenosine A3 receptor antagonists. In: XXV Congresso Nazionale della Società Chimica Italiana, Arcavacata di Rende (CS), 7-12 settembre 2014, d, pp. 373-373.

Lucia Squarcialupi; Vittoria Colotta; Daniela Catarzi; Flavia Varano; Betti Marco; Katia Varani; Fabrizio Vincenzi; Pier Andrea Borea; Nicola Porta; Antonella Ciancetta; Stefano Moro (2014). 7-Amino-2-phenylpyrazolo[4,3-d]pyrimidine derivatives: Structural investigations at the 5-position to target human A1 and A2A adenosine receptors. Molecular modeling and pharmacological studies. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 84, pp. 614-627, ISSN:0223-5234 DOI

D. Catarzi; V. Colotta; F. Varano; L. Squarcialupi; K. Varani (2014). Imidazo[1,2-a]pyrazine core for the design of new adenosine receptor antagonist: optimization of A3 affinity and structural exploration to target the A2A subtype. In: XXV Congresso Nazionale della Società Chimica Italiana, Arcavacata di Rende (CS), 2-12 settembre 2014, d, pp. 347-347.

F. Varano; D. Catarzi; V. Colotta; L. Squarcialupi; K. Varani. (2013). Thiazolo[5,4-d]pyrimidin-7-amino derivatives as new human A2A adenosine receptor antagonists. In: 5th Joint Italian-German Purine Club Meeting, Rimini, 18-21 september 2013, d, pp. 64-64.

F. Varano; D. Catarzi; V. Colotta; L. Squarcialupi; R. Matucci. (2013). 2-Hydroxy-1,2,4-benzothiadiazin-1,1-dioxide derivatives as new antagonists of ionotropic glutamate receptors. In: 22st National Meeting on Medicinal Chemistry, Roma, 10-13 september 2013, d, pp. P.CD.21-P.CD.21.

V. Colotta; L. Squarcialupi; D. Catarzi; F. Varano; K. Varani; F. Vincenzi; A. Ciancetta; S. Moro (2013). Exploring the effect of 2- and 5-substituents on the pyrazolo[4,3-d]pyrimidin-7-amino derivatives to obtain human adenosine receptor antagonists. In: 5th Joint Italian-German Purine Club Meeting, Rimini, september 18-21 2013, d, pp. 65-66.

Lucia Squarcialupi;Vittoria Colotta;Daniela Catarzi;Flavia Varano;Guido Filacchioni;Katia Varani;Carmen Corciulo;Fabrizio Vincenzi;Pier Andrea Borea;Carla Ghelardini;Lorenzo Di Cesare Mannelli;Antonella Ciancetta;Stefano Moro (2013). 2-Arylpyrazolo[4,3-d]pyrimidin-7-amino Derivatives As New Potent and Selective Human A3Adenosine Receptor Antagonists. Molecular Modeling Studies and Pharmacological Evaluation. JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, pp. 2256-2269, ISSN:0022-2623 DOI

Daniela Catarzi;Vittoria Colotta;Flavia Varano;Daniela Poli;Lucia Squarcialupi;Guido Filacchioni;Katia Varani;Fabrizio Vincenzi;Pier Andrea Borea;Diego Dal Ben;Catia Lambertucci;Gloria Cristalli (2013). Pyrazolo[1,5-c]quinazoline derivatives and their simplified analogues as adenosine receptor antagonists: Synthesis, structure–affinity relationships and molecular modeling studies. BIOORGANIC & MEDICINAL CHEMISTRY, pp. 283-294, ISSN:0968-0896 DOI

L. Squarcialupi; V. Colotta; D. Catarzi; F. Varano; K. Varani; C. Corciulo; F. Vincenzi; A. Ciancetta; L. Di Cesare Mannelli; C. Ghelardini; S. Moro (2013). Arilpirazolo[4,3-d]pirimidin-7-ammino derivati quali nuovi antagonisti potenti e selettivi del recettore umano A3 dell’adenosina. In: TUMA 2013, Sesto Fiorentino (FI), 1-2-Luglio 2013, d, pp. 60-60.

L. Squarcialupi; V. Colotta; D. Catarzi; F. Varano; K. Varani; F. Vincenzi; D. Sabbadin; S. Moro (2013). Structural investigations on 2-Arylpyrazolo[4,3-d]pyrimidin-7-amino derivatives as new human adenosine receptor antagonists.. In: 22st National Meeting on Medicinal Chemistry, Roma, 10-13 september 2013, d, pp. P.CD.05-P.CD.05.

D. Catarzi; F. Varano; V. Colotta; L. Squarcialupi; R. Matucci; L. di Cesare Mannelli; M.Zanardelli (2013). Synthesis and Pharmacological evaluation of some new 8-substitute-7-trifluoromethyl-4,5-dihydro-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates as AMPA/Kainate receptor antagonists. In: 22st National Meeting on Medicinal Chemistry, Roma, 10-13 september 20013, d, pp. P.CD.03-P. CD. 03.

D. Catarzi; V. Colotta; F. Varano; L. Squarcialupi; K. Varani; A.M. Pugliese; F. Pedata; I. Palchetti (2013). 2-Arylimidazo[1,2-a]pyrazin-8-amino derivatives as high-affinity fluorescent human A3 adenosine receptor antagonists with potential neuroprotective properties. In: 5th Joint Italian-German Purine Club Meeting, Rimini, 18-21 september 2013, d, pp. 63-64.

Colotta V;Lenzi O;Catarzi D;Varano F;Squarcialupi L;Costagli C;Galli A;Ghelardini C;Pugliese AM;Maraula G;Coppi E;Pellegrini-Giampietro DE;Pedata F;Sabbadin D;Moro S (2012). 3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new antagonists at ionotropic glutamate receptors: Molecular modeling and pharmacological studies.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, pp. 470-482, ISSN:0223-5234 DOI

V. Colotta; L. Squarcialupi; D. Catarzi; F. Varano; K. Varani; F. Vincenzi; M. Zanardelli; L. Di Cesare Mannelli; C. Ghelardini; S. Paoletta; S. Moro (2012). 2-Arylpyrazolo[4,3-d]pyrimidin-7-amino derivatives, new potent and selective human A3 adenosine receptor antagonists endowed with protective effect against oxaliplatin-induced apoptosis in rat astrocyte cell cultures. In: 21st National Meeting on Medicinal Chemistry, Palermo, 17-20 Luglio 2012, d, pp. 0-0.

V. Colotta; D. Catarzi; F. Varano; C. Costagli; C. Ghelardini; A.M. Pugliese; G. Maraula; D. Sabbadin; S. Moro (2011). 3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new antagonists at ionotropic glutamate receptors: molecular modeling and pharmacological studies. In: XXIV Congresso Nazionale della Società Chimica Italiana, Lecce, 11-16 settembre 2011, d, pp. 388-388.

O. Lenzi; V. Colotta; D. Catarzi; F. Varano; L. Squarcialupi; G. Filacchioni; K. Varani; F. Vincenzi; P. A. Borea; D. Dal Ben; C. Lambertucci; G. Cristalli (2011). Synthesis, structure-affinity relationships, and molecular modeling studies of novel pyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, pp. 3757-3768, ISSN:1464-3391

D. Poli; D. Catarzi; V. Colotta; F. Varano; G. Filacchioni; S. Daniele; L. Trincavelli; C. Martini; S. Paoletta; S. Moro (2011). The identification of the 2-phenylphthalazin-1(2H)-one scaffold as a new decorable core skeleton for the design of potent and selective human A3 adenosine receptor antagonists.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, pp. 2102-2113, ISSN:1520-4804

D. Catarzi; V. Colotta; F. Varano; K. Varani; S. Paoletta; S. Moro (2011). Novel 8-aroylamini-2-phenylimidazo[1,2-a]pyrazines as human A3 adenosine receptor antagonists. In: XXIV Congresso Nazionale della Società Chimica Italiana, Lecce, 11-16 settembre 2011, d, pp. 385-385.

D. Catarzi; O. Lenzi; V. Colotta; F. Varano; D. Poli; G. Filacchioni; K. Lingenhohl; S. Ofner (2010). Pharmacological characterization of some selected 4,5-dihydro-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates and 3-hydroxyquinazoline-2,4-diones as (S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)-propionic acid receptor antagonists.. CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 58, pp. 908-911, ISSN:0009-2363

F. Varano; D. Catarzi; V. Colotta; D. Poli; G. Filacchioni; A. Galli; C. Costagli (2009). Synthesis and biological evaluation of a new set of pyrazolo[1,5-c]quinazolines as glycine/N-methyl-D-aspartic acid receptor antagonists. CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 57, pp. 826-829, ISSN:0009-2363

O. Lenzi; V. Colotta; D. Catarzi; F. Varano; D. Poli; G. Filacchioni; K. Varani; F. Vincenzi; P. A. Borea; S. Paoletta; E. Morizzo; S. Moro. (2009). 2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a New Scaffold to obtain Potent and Selective Human A3 Adenosine Receptor Antagonists: New Insights into the Receptor-Antagonist Recognition†. JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, pp. 7640-7652, ISSN:0022-2623

E. Morizzo; V. Colotta; D. Catarzi; F. Varano; S. Federico; G. Spalluto; T. Stockner; S. Moro (2009). G protein-coupled receptors as potential drug target: from receptor topology to rational drug design, an in silico approach. In: Nuove Prospettive in Chimica farmaceutica. III meeting-workshop, Il Ciocco, Castelvecchio Pascoli (LU), 13-14 febbraio 2009, d, pp. 0-0.

V. Colotta; F. Capelli; O. Lenzi; D. Catarzi; F. Varano; D. Poli; F. Vincenzi; K. Varani; P.A. Borea; D. Dal Ben; R. Volpini; G. Cristalli; G. Filacchioni (2009). Novel potent and highly selective human A3 adenosine receptor antagonists belonging to the 4-amido-2-arylpyrazolo[3,4-c]quinoline series: molecular docking analysis and pharmacological studies. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 17, pp. 401-410, ISSN:0968-0896

V. Colotta; O. Lenzi; D. Catarzi; F. Varano; G. Filacchioni; C. Martini; L. Trincavelli; O. Ciampi; A. M. Pugliese; C. Traini; F. Pedata; E. Morizzo; S. Moro (2009). Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a New Scaffold To Develop Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation, and Ligand-Receptor Modeling Studies.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, pp. 2407-2419, ISSN:0022-2623 DOI

D. Dal Ben; O. Lenzi; D. Catarzi; F. Varano; F. Vincenzi; K. Varani; P. A. Borea; G. Filacchioni; G. Cristalli; V. Colotta. (2008). Novel 4-amido-2-arylpyrazolo[3,4-c]quinolines as highly potent and selective human adenosine A3 receptor antagonists. Molecular Docking Analysis and Pharmacological Studies.. PURINERGIC SIGNALLING, pp. 15-15, ISSN:1573-9538

V.COLOTTA; D.CATARZI; F.VARANO; O.LENZI; G.FILACCHIONI; C.MARTINI; L.TRINCAVELLI; O.CIAMPI; C.TRAINI; A.PUGLIESE; F.PEDATA; E.MORIZZO; S.MORO. (2008). Synthesis, ligand-receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, pp. 6086-6102, ISSN:0968-0896 DOI

Daniela CATARZI, Vittoria COLOTTA, Flavia VARANO, Guido FILACCHIONI, Paola GRATTERI, Jacopo SGRIGNANI, Alessandro GALLI, Chiara Costagli (2008). Synthesis and biological evaluation of novel 9-heteroaryl substituted 7-chloro-4,5-dihydro-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates (TQX) as AMPA receptor antagonists.. CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 56, pp. 1085-1091, ISSN:0009-2363 DOI

F. Varano; D. Catarzi; V. Colotta; O. Lenzi; G. Filacchioni; A. Galli; C. Costagli (2008). Novel AMPA and kainate receptor antagonists containing the pyrazolo[1,5-c]quinazoline ring system: synthesis and structure-activity relationships. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, pp. 2617-2626, ISSN:1464-3391

E. Morizzo; F. Capelli; O. Lenzi; D. Catarzi; F.Varano; G. Filacchioni; F. Vincenzi; K. Varani; P.A.Borea; V. Colotta; S. Moro. (2007). Scouting Human A3 Adenosine Receptor Antagonist Binding Mode Using a Molecular Simplification Approach: From Triazoloquinoxaline to a Pyrimidine Skeleton as a Key Study. JOURNAL OF MEDICINAL CHEMISTRY, vol. 50, pp. 6596-6606, ISSN:0022-2623

M. BACILIERI; F.VARANO; F.DEFLORIAN; M.MARINI; D.CATARZI; V.COLOTTA; G.FILACCHIONI; A.GALLI; C.COSTAGLI; C.KASEDA; S.MORO (2007). Tandem 3D-QSARs Approach as a Valuable Tool To Predict Binding Affinity Data: Design of New Gly/NMDA Receptor Antagonists as a Key Study.. JOURNAL OF CHEMICAL INFORMATION AND MODELING, vol. 47, pp. 1913-1922, ISSN:1549-9596

V. Colotta; D. Catarzi; F. Varano; F. Capelli; O. Lenzi; G. Filacchioni; L. Trincavelli; K. Varani; A.M. Pugliese; D. Dal Ben; S. Moro (2007). Progettazione e sintesi di nuovi antagonisti del recettore A3 dell’adenosina: 2-aril-1,2,4-triazolo[4,3-a]quinoxalin-1-oni e loro analoghi strutturali. In: XVIII Convegno Nazionale della Divisione di Chimica Farmaceutica della Società Chimica Italiana. Chieti, Chieti, 16-20 settembre 2007, d, pp. 30-30.

V. COLOTTA; D. CATARZI; F. VARANO; F. CAPELLI; O. LENZI; G. FILACCHIONI; C. MARTINI; L. TRINCAVELLI; O. CIAMPI; A. PUGLIESE; F. PEDATA; A. SCHIESARO; E. MORIZZO; S. MORO (2007). New 2-Arylpyrazolo[3,4-c]quinoline Derivatives as Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation and Ligand-Receptor Modeling Studies.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 50, pp. 4061-4074, ISSN:0022-2623 DOI

D.CATARZI; V.COLOTTA; F.VARANO. (2007). Competitive AMPA receptor antagonists.. MEDICINAL RESEARCH REVIEWS, vol. 27, pp. 239-278, ISSN:0198-6325

O. LENZI; V. COLOTTA; D. CATARZI; F.VARANO; G. FILACCHIONI; C. MARTINI; L. TRINCAVELLI; OSELE CIAMPI; KATIA VARANI; FEDERICO MARIGHETTI; ERIKA MORIZZO; STEFANO MORO (2006). 4-Amido-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-ones as New Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation and Ligand-Receptor Modeling Studies.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, pp. 3916-3925, ISSN:0022-2623

V. COLOTTA; D. CATARZI; F. VARANO; O. LENZI; G. FILACCHIONI; C. COSTAGLI; A. GALLI; C. GHELARDINI; N. GALEOTTI; P.GRATTERI; J.SGRIGNANI; F. DEFLORIAN; S. MORO; (2006). Structural Investigation of the 7-Chloro-3-hydroxy-1H-quinazoline-2,4-dione Scaffold to Obtain AMPA and Kainate Receptor Selective Antagonists. Synthesis, Pharmacological and Molecular Modeling Studies. JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, pp. 6015-6026, ISSN:0022-2623 DOI Accesso ONLINE all'editore

S.MORO; F.VARANO; G.COZZA; M.A.PAGANO; G.ZAGOTTO; A.CHILIN; A.GUIOTTO; D.CATARZI; V.COLOTTA; L.A.PINNA; F.MEGGIO. (2006). Pyrazoloquinazoline tricyclic system as novel scaffold to design new kinase CK2 inhibitors.. LETTERS IN DRUG DESIGN & DISCOVERY, vol. 3, pp. 281-284, ISSN:1570-1808

V. Colotta; D. Catarzi; F. Varano; F. Capelli; O. Lenzi; L. Trincavelli; S. Moro (2006). 2- Arylpyrazolo[3,4.c]quinolin-4-acylamines as potent and selective human A3 adenosine receptor antagonists. Synthesis, biological evaluation and molecular modeling studies. PURINERGIC SIGNALLING, pp. 75-75, ISSN:1573-9538

D. Catarzi; V. Colotta; F. Varano; F. Capelli; O. Lenzi; K. Varani (2006). 2-Arylpyrazolo[3,4.c]quinolin-4-heteroaroylamines as potent and selective human A3 adenosine receptor antagonists. Synthesis and biological evaluation. PURINERGIC SIGNALLING, pp. 74-74, ISSN:1573-9538

J. Sgrignani; C. Bonaccini; F. Melani; D. Catarzi; P. Gratteri (2006). Docking and 3D-QSAR analysis on i-GluR2 receptor. In: XXII Congresso Nazionale della Società Chimica Italiana., Firenze, 10-15 settembre 2006, d, pp. 188-188.

D.CATARZI; V.COLOTTA; F.VARANO (2006). Competitive Gly/NMDA receptor antagonists. CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 6, pp. 809-821, ISSN:1568-0266

D. CATARZI; V. COLOTTA; F. VARANO; O. LENZI; G. FILACCHIONI; L. TRINCAVELLI; C. MARTINI; C. MONOPOLI; S. MORO (2005). 1,2,4-Triazolo[1,5-a]quinoxaline as a versatile tool for the design of selective human A3 adenosine receptor antagonists: synthesis, biological evaluation and molecular modeling studies of 2-(hetero)aryl- and 2-carboxy-substituted derivatives.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, pp. 7932-7945, ISSN:0022-2623

D.CATARZI; V.COLOTTA; F. VARANO; F.R.CALABRI; O.LENZI; G. FILACCHIONI; L.TRINCAVELLI; C. MARTINI; A.TRALLI; C.MONTOPOLI; S.MORO (2005). 2-Aryl-8-chloro-1,2,4-triazolo[1,5-a]quinoxalin-4-amines as highly potent A1 and A3 adenosine receptor antagonists. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 13, pp. 705-715, ISSN:0968-0896

F.CALABRI; V. COLOTTA; D. CATARZI; F. VARANO; O.LENZI; G. FILACCHIONI; C.COSTAGLI; A. GALLI. (2005). Synthesis and Pharmacological Studies at the Gly/NMDA, AMPA and Kainate Receptors of New Oxazolo[4,5-c]quinolin-4-one derivatives bearing different substituents at position-2 and on the fused benzo ring. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 40, pp. 897-907, ISSN:0223-5234

F.VARANO; D. CATARZI; V. COLOTTA; F. R. CALABRI; O. LENZI; G. FILACCHIONI; A. GALLI; C. COSTAGLI; F. DEFLORIAN; S. MORO (2005). 1-Substituted pyrazolo[1,5-c]quinazolines as novel Gly/NMDA receptor antagonists: synthesis, biological evaluation and molecular modeling study. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 13, pp. 5536-5549, ISSN:0968-0896

D. Catarzi; V. Colotta; F. Varano; F. R. Calabri; O. Lenzi; C. Costagli (2004). 9-Eteroaril-4,5-diidro-4-oxo-1,2,4-triazolo[1,5-a]chinossaline-2-carbossilati antagonisti dei recettori degli amminoacidi eccitatori. In: XVII Convegno Nazionale della Divisione di Chimica Farmaceutica della Società Chimica Italiana, Pisa, 6-10 settembre 2004, d, pp. 96-96.

D. Catarzi; V. Colotta; F. Varano; F. R. Calabri; O. Lenzi; L. Trincavelli (2004). Derivati a struttura 4-oxo-imidazo[4,5-c]chinolinica quali antagonisti dei recettori Gly/NMDA, AMPA e KA. In: XVII Convegno Nazionale della Divisione di Chimica Farmaceutica della Società Chimica Italiana, Pisa, 6-10 settembre 2004, d, pp. 95-95.

O. Lenzi; V. Colotta; D. Catarzi; F. Varano; F. R. Calabri; L. Trincavelli (2004). 4-N-acilammino e 4-N-sulfonilammino-2-aril-1,2-diidro-1,2,4-triazolo[4,3-a]chinossalin-1-oni: nuovi potenti antagonisti del recettore A3 dell’adenosina. In: XVII Convegno Nazionale della Divisione di Chimica Farmaceutica della Società Chimica Italiana, Pisa, 6-10 settembre 2004, d, pp. 162-162.

D. Catarzi; V. Colotta; F. Varano; F. R. Calabri; O. Lenzi; S. Moro; C. Montopoli; A. Tralli; L. Trincavelli (2004). Sintesi e relazioni struttura-attività di derivati a struttura 2-aril-8-cloro-1,2,4-triazolo[1,5-a]chinossalinica quali antagonisti potenti e selettivi dei recettori A1 ed A3 dell’adenosina. In: XVII Convegno Nazionale della Divisione di Chimica Farmaceutica della Società Chimica Italiana., Pisa, 6-10 settembre 2004, d, pp. 94-94.

V. COLOTTA; D. CATARZI; F. VARANO; F. R. CALABRI; G. FILACCHIONI; C. COSTAGLI; A. GALLI. (2004). “3-Hydroxy-quinazoline-2,4-dione as a useful scaffold to obtain selective Gly/NMDA and AMPA receptor antagonists”. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, pp. 2345-2349, ISSN:0960-894X

D. CATARZI; V. COLOTTA; F. VARANO; G.FILACCHIONI; C. MARTINI; L. TRINCAVELLI; A. LUCACCHINI (2004). “1,2,4-TRIAZOLO[1,5-A]QUINOXALINE DERIVATIVES: SYNTHESIS AND BIOLOGICAL EVALUATION AS ADENOSINE RECEPTOR ANTAGONISTS”. IL FARMACO, vol. 59, pp. 71-81, ISSN:0014-827X

V. COLOTTA; D. CATARZI; F.VARANO; F. R. CALABRI; O. LENZI; G. FILACCHIONI; C. MARTINI; L. TRINCAVELLI; FRANCESCA DEFLORIAN; STEFANO MORO (2004). The 1,2,4-Triazolo[4,3-a]quinoxalin-1-one Moiety as an Attractive Scaffold to Develop New Potent and Selective Human A3 Adenosine Receptor Antagonists: Synthesis, Pharmacological and Ligand-Receptor Modeling Studies.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 47, pp. 3580-3590, ISSN:0022-2623

V. COLOTTA; D. CATARZI; F. VARANO; G.FILACCHIONI; C. MARTINI; L. TRINCAVELLI; A. LUCACCHINI (2004). SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF 4-CYCLOALKYLAMINO-1,2,4-TRIAZOLO[4,3-A]QUINOXALIN-1-ONE DERIVATIVES AS A1 AND A3 ADENOSINE RECEPTOR ANTAGONISTS.. ARCHIV DER PHARMAZIE, vol. 337, pp. 35-41, ISSN:0365-6233

F. R. Calabri; V. Colotta; D. Catarzi; F. Varano; O. Lenzi; C. Costagli (2004). Sintesi di nuovi ossazolo[4,5-c]chinolin-oni, variamente sostituiti sul benzene condensato ed in posizione –2, quali antagonisti del recettore Glicina/NMDA. In: XVII Convegno Nazionale della Divisione di Chimica Farmaceutica della Società Chimica Italiana, Pisa, 6-10 settembre 2004, d, pp. 85-85.

F. Varano; V. Colotta; D. Catarzi; F. R. Calabri; O. Lenzi; C. Costagli (2004). Pirazolo[1,5-c]chinazoline 1-carbossi sostituite: nuovi antagonisti del recettore Gly/NMDA. In: XVII Convegno Nazionale della Divisione di Chimica Farmaceutica della Società Chimica Italiana, Pisa, 6-10 settembre 2004, d, pp. 107-107.

D. CATARZI; V. COLOTTA; F. VARANO; F. CALABRI; G. FILACCHIONI; A. GALLI; C. COSTAGLI; A. CARLA'. (2004). Synthesis and biological evaluation of analogues of 7-chloro-4,5-dihydro-4-oxo-8-(1,2,4-triazol-4-yl)-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylic acid (TQX-173) as novel selective AMPA receptor antagonists. JOURNAL OF MEDICINAL CHEMISTRY, vol. 47, pp. 262-272, ISSN:0022-2623

V. COLOTTA; D. CATARZI; F.VARANO; G. FILACCHIONI; C. MARTINI; L. TRINCAVELLI; A. LUCACCHINI (2003). Synthesis of 4-amino-6-(hetero)arylalkylamino-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent A2A adenosine receptor antagonists.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11, pp. 5509-5518, ISSN:0968-0896

V. COLOTTA; D. CATARZI; F. VARANO; G.FILACCHIONI; C. MARTINI; L. TRINCAVELLI; A. LUCACCHINI (2003). Synthesis and structure-activity relationships of a new set of 1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as adenosine receptor antagonists.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11, pp. 3541-3550, ISSN:0968-0896

F. Varano; D. Catarzi; V. Colotta; C. Costagli (2002). Synthesis and structure-activity relationships of a new set of 1-substituted-5-oxo-pyrazolo[1,5-c]quinazoline-2-carboxylic acid derivatives as excitatory aminoacid antagonits. DRUGS OF THE FUTURE, pp. 170-170, ISSN:0377-8282

F.VARANO; D.CATARZI; V.COLOTTA; G. FILACCHIONI; A.GALLI; C.COSTAGLI; V. CARLA'. (2002). Synthesis and biological evaluation of a new set of pyrazolo[1,5-c]quinazoline-2-carboxylates as novel excitatory amino acid antagonists. JOURNAL OF MEDICINAL CHEMISTRY, vol. 45, pp. 1035-1044, ISSN:0022-2623

D. Catarzi; V. Colotta; F. Varano; C. Costagli (2002). Design and synthesis of a new set of 4-oxo-imidazo[4,5-c]quinolines as ionotropic glutamate receptor antagonists. DRUGS OF THE FUTURE, pp. 171-171, ISSN:0377-8282

Vittoria Colotta; Daniela Catarzi; Flavia Varano; Letizia Trincavelli. (2002). New 2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-ones as human A3 adenosine receptor antagonists. DRUGS OF THE FUTURE, pp. 187-187, ISSN:0377-8282

Daniela Catarzi; Vittoria Colotta; Flavia Varano; Chiara Costagli (2001). 8-Heteroaryl-4,5-dihydro-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylate analogs of TQX-173: selective antagonists of the AMPA receptor. In: Hungarian-German-Italian-Polish Meeting on Medicinal Chemistry, Budapest, 2-6 september 2001, d, pp. 58-58.

Vittoria Colotta; Daniela Catarzi; Flavia Varano; Chiara Costagli (2001). Synthesis and structure-activity relationships of 3-hydroxy-quinazolin-2,4-dione derivatives as glicine/NMDA, AMPA and Kainate receptor antagonists. In: Hungarian-German-Italian-Polish Meeting on Medicinal Chemistry, Budapest, 2-6 september 2001, dd, pp. 62-62.

D.CATARZI; V.COLOTTA; F. VARANO; G. FILACCHIONI; A. GALLI; C.COSTAGLI ; V.CARLA' (2001). Synthesis, Ionotropic glutamate receptor binding affinity and structure-activity relationships of a new set of 4,5-dihydro-8-heteroaryl-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates analogue of TQX-173. JOURNAL OF MEDICINAL CHEMISTRY, vol. 44, pp. 3157-3165, ISSN:0022-2623

F.VARANO; D.CATARZI; V.COLOTTA; L.CECCHI; G. FILACCHIONI; A.GALLI; C. COSTAGLI (2001). Synthesis of a set of ethyl 1-carbamoyl-3-oxoquinoxaline-2-carboxylates and their constrained analogue imidazo[1,5-a]quinoxalines-1,3,4-triones as selective Glycine/NMDA receptor antagonists.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 36, pp. 203-209, ISSN:0223-5234

Flavia Varano; Daniela Catarzi; Vittoria Colotta; Letizia Trincavelli (2001). Tricyclic heteroaromatic systems. 2-Carboxy-substituted-1,2,4-triazolo[1,5-a]quinoxalines as adenosine receptor antagonists. In: Hungarian-German-Italian-Polish Meeting on Medicinal Chemistry, Budapest, 2-6 september 2001, d, pp. 177-177.

Flavia Varano; Daniela Catarzi; Vittoria Colotta; Chiara Costagli (2000). Tricyclic heteroaromatic system. 5,6-dihydro-5-oxo-pyrazolo[1,5-c]quinazolines as excitatory amino acid antagonists. In: XVI International Symposium on Medicinal Chemistry, Bologna, 19-22 settembre 2000, cl, pp. 211-211.

Daniela Catarzi; Vittoria Colotta; Flavia Varano; Letizia Trincavelli (2000). 4,5-Dihydro-2-phenyl-1,2,4-triazolo[1,5-a]quinoxaline derivatives as highly potent and selective A3 adenosine receptor antagonists. In: XVI International Symposium on Medicinal Chemistry, Bologna, 19-22 settembre 2000, cl, pp. 174-174.

Vittoria Colotta; Daniela Catarzi; Flavia Varano; Letizia Trincavelli (2000). Benzosubstituted 2-phenyl-1,2,4-triazolo[4,3-a]quinoxalin-1-ones. Synthesis and binding activity on adenosine receptors. In: XVI International Symposium on Medicinal Chemistry, Bologna, 18-22 settembre 2000, cl, pp. 176-176.

V. COLOTTA; D. CATARZI; F.VARANO; L. CECCHI; G. FILACCHIONI; C. MARTINI; L. TRINCAVELLI; A. LUCACCHINI (2000). Synthesis and Structure-Activity Relationships of a new set of 2-arylpyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, pp. 3118-3124, ISSN:0022-2623

Vittoria Colotta; Daniela Catarzi; Flavia Varano; Letizia Trincavelli (2000). 6-Aralkylamino-1,2-dihydro-2-phenyl-1,2,4-triazolo[4,3-a]quinoxalin-1-ones as A2A adenosine receptor antagonists. In: XVI International Symposium on Medicinal Chemistry, Bologna, 18-22 settembre 2000, cl, pp. 175-175.

Flavia Varano; Daniela Catarzi; Vittoria Colotta; Chiara Costagli (2000). Synthesis of a set of pyrazolo[1,5-c]quinazolines as novel glycine/NMDA antagonists. In: XVI International Symposium on Medicinal Chemistry, Bologna, september 18-22-2000, cl, pp. 212-212.

V. COLOTTA; D. CATARZI; F. VARANO; L.CECCHI; G.FILACCHIONI; C. MARTINI; L. TRINCAVELLI; A. LUCACCHINI (2000). 1,2,4-Triazolo[4,3-a]quinoxalin-1-one: a versatile tool for the synthesis of potent and selective adenosine receptor antagonists.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, pp. 1158-1164, ISSN:0022-2623

D.CATARZI; V.COLOTTA; F.VARANO; L.CECCHI; G.FILACCHIONI; A.GALLI; C. COSTAGLI; V.CARLA' (2000). 7-Chloro-4,5-dihydro-8-(1,2,4-triazol-4-yl)-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates as novel highly selective AMPA receptor antagonists.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, pp. 3824-3826, ISSN:0022-2623

F. VARANO; D. CATARZI; V. COLOTTA; L. CECCHI; G.FILACCHIONI; A. GALLI; C. COSTAGLI (1999). Synthesis, glycine/NMDA and AMPA binding activity of some new 2,5,6-trioxopyrazino[1,2,3-de]quinoxalines and of their restricted analogs 2,5-dioxo- and 4,5-dioxoimidazo[1,5,4-de]quinoxalines.. ARCHIV DER PHARMAZIE, vol. 332, pp. 201-207, ISSN:0365-6233

Vittoria Colotta; Daniela Catarzi; Flavia Varano; Letizia Trincavelli (1999). 1,2,4-triazolo[4,3-a]quinoxalin-1-one as a framework to obtain potent and selective A1, A2A and A3 adenosine receptor antagonists. In: Italian-Hungarian-Polish Joint Meeting on Medicinal Chemistry, Giardini Naxos Taormina, d, pp. 225-225.

D. CATARZI; V. COLOTTA; F. VARANO; L. CECCHI; G. FILACCHIONI; A. GALLI; C. COSTAGLI (1999). 4,5-Dihydro-1,2,4-triazolo[1,5-a]quinoxalin-4-ones. Excitatory amino acid antagonists with combined glycine/NMDA and AMPA receptor affinity. JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, pp. 2478-2484, ISSN:0022-2623

V. COLOTTA; D. CATARZI; F. VARANO; L. CECCHI; G. FILACCHIONI; C. MARTINI; L. TRINCAVELLI; A. LUCACCHINI (1999). 4-Amino-6-benzylamino-1,2-dihydro-2-phenyl-1,2,4-triazolo[4,3-a] quinoxalin-1-one: a new A2A adenosine receptor antagonist with high selectivity versus A1 receptors.. ARCHIV DER PHARMAZIE, vol. 332, pp. 39-41, ISSN:0365-6233

Daniela Catarzi; Vittoria Colotta; Flavia Varano; Chiara Costagli (1999). 4-Oxo-1,2,4-triazolo[1,5-a]quinoxalin-2-carboxylic acid derivatives: antagonists of the Glycine/NMDA and AMPA receptors.. In: Italian-Hungarian-Polish Joint Meeting on Medicinal Chemistry, d, pp. 216-216.

F. VARANO; D. CATARZI; V. COLOTTA; L. CECCHI; G.FILACCHIONI; A. GALLI; C. COSTAGLI (1998). Synthesis of 2-substituted-3,4-dihydro-3-oxo-6,8-dichloro-2H-1,4-benzothiazin-1,1-dioxides and 1-oxides as glycine-NMDA receptor antagonists.. IL FARMACO, vol. 53, pp. 752-757, ISSN:0014-827X

V. COLOTTA; D. CATARZI; F. VARANO; L. CECCHI; G. FILACCHIONI; C. MARTINI; L. GIUSTI; A. LUCACCHINI (1998). Tricyclic heteroaromatic systems. Synthesis and benzodiazepine receptor affinity of 2-substituted-1-benzopyrano[3,4-d]oxazol-4-ones, -thiazol-4-ones, and –imidazol-4-ones.. IL FARMACO, vol. 53, pp. 375-381, ISSN:0014-827X

V. COLOTTA; D. CATARZI; F. VARANO; F. MELANI; G.FILACCHIONI; L. CECCHI; L. TRINCAVELLI; C. MARTINI; A. LUCACCHINI (1998). Synthesis and A1 and A2A binding activity of some pyrano[2,3-c]pyrazol-4-ones.. IL FARMACO, vol. 53, pp. 189-196, ISSN:0014-827X

V. COLOTTA; D. CATARZI; F. VARANO; L. CECCHI; G. FILACCHIONI; A. GALLI; C. COSTAGLI. (1997). Tricyclic heteroaromatic systems. 1,2,4-triazolo[4,3-a]quinoxalines and 1,2,4-triazino[4,3-a]quinoxalines: synthesis and central benzodiazepine receptor activity.. ARCHIV DER PHARMAZIE, vol. 330, pp. 387-391, ISSN:0365-6233

V. COLOTTA; D. CATARZI; F. VARANO; L. CECCHI; G.FILACCHIONI; A. GALLI; C. COSTAGLI (1997). Synthesis and biological evaluation of a series of quinazoline-2-carboxylic acids and quinazolin-2,4-diones as glycine-NMDA antagonists: a pharmacophore model based approach.. ARCHIV DER PHARMAZIE, vol. 330, pp. 129-134, ISSN:0365-6233

F. VARANO; D. CATARZI; V. COLOTTA; L. CECCHI; G. FILACCHIONI; A. GALLI; C. COSTAGLI. (1997). Tricyclic Heteroaromatic systems. 3-Substituted 1,2,3,5,6,7-hexahydro-2,5,6-trioxopyrazino[1,2,3-de]quinoxalines as novel antagonists at the glycine-NMDA site.. IL FARMACO, vol. 52, pp. 179-182, ISSN:0014-827X

D. CATARZI; V. COLOTTA; F. VARANO; L. CECCHI; G.FILACCHIONI; A. GALLI; C. COSTAGLI (1997). Tricyclic heteroaromatic systems. Pyrazolo[3,4-c]quinolin-4-ones and pyrazolo[3,4-c]quinoline-1,4-diones: synthesis and benzodiazepine receptor activity.. ARCHIV DER PHARMAZIE, vol. 330, pp. 383-386, ISSN:0365-6233

V. COLOTTA; D. CATARZI; F. VARANO; L. CECCHI; G.FILACCHIONI; A. GALLI; C. COSTAGLI (1996). Synthesis and binding activity of some pyrazolo[1,5-c]quinazolines as tools to verify an optional binding site of a benzodiazepine receptor ligand.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 39, pp. 2915-2921, ISSN:0022-2623

V. COLOTTA; D. CATARZI; F. VARANO; F. MELANI; G.FILACCHIONI; L. CECCHI; A. GALLI; C. COSTAGLI (1996). Benzodiazepine binding activity of some tricyclic heteroarometic systems to define the hydrogen bonding strength of the proton donors of the receptor site.. IL FARMACO, vol. 51, pp. 223-229, ISSN:0014-827X

F. VARANO; D. CATARZI; V. COLOTTA; L. CECCHI; G.FILACCHIONI; A. GALLI; C. COSTAGLI (1996). Structure-activity relationship studies of novel pyrazolo[1,5-c][1,3]benzoxazines: synthesis and benzodiazepine receptor affinity.. ARCHIV DER PHARMAZIE, vol. 329, pp. 529-534, ISSN:0365-6233

D. CATARZI; L. CECCHI; V. COLOTTA; G.FILACCHIONI; C. MARTINI; P.TACCHI; A. LUCACCHINI (1995). TRICYCLIC HETEROAROMATIC SYSTEMS. SYNTHESIS AND A1 AND A2A ADENOSINE BINDING ACTIVITIES OF SOME 1-ARYL-1,4-DIHYDRO-3-METHYL[1]BENZOPYRANO[2,3-C]PYRAZOL-4-ONES, 1-ARYL-4,9-DIHYDRO-3-METHYL-1H-PYRAZOLO[3,4-B]QUINOLIN-4-ONES, AND 1-ARYL-1H-IMIDAZO[4,5-B]QUINOXALINES.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 38, pp. 1330-1336, ISSN:0022-2623

D. CATARZI; L. CECCHI; V. COLOTTA; G. FILACCHIONI; F. VARANO; C. MARTINI; L. GIUSTI; A. LUCACCHINI (1995). SYNTHESIS OF SOME 2-ARYL-1,2,4-TRIAZOLO[1,5-C][1,3]BENZOXAZIN-5-ONES AS TOOLS TO DEFINE THE ESSENTIAL PHARMACOPHORIC DESCRIPTORS OF A BENZODIAZEPINE RECEPTOR LIGAND.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 38, pp. 2196-2201, ISSN:0022-2623

V. COLOTTA, L. CECCHI, D. CATARZI, G.FILACCHIONI, C. MARTINI, P. TACCHI; A.LUCACCHINI (1995). Synthesis of some tricyclic heteroaromatic systems and their A1 and A2a adenosine binding activity.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 30, pp. 133-139, ISSN:0223-5234

Daniela Catarzi; Lucia Cecchi; Vittoria Colotta; Guido Filacchioni; Flavia Varano (1995). Hydrogen bonding power and benzodiazepine receptor affinity relationships of 2-phenyl and 2-carbethoxy- tricyclic derivatives. In: 10th Camerino-Noordwijkerhout Symposium, Camerino, 10-14 settembre 1995, Università di Camerino, pp. 191-192.

D. CATARZI; L. CECCHI; V. COLOTTA; F. MELANI; G.FILACCHIONI; C. MARTINI; L.GIUSTI; A. LUCACCHINI. (1994). STRUCTURE-ACTIVITY RELATIONSHIPS OF 1,2,4-TRIAZOLO[1,5-A]QUINOXALINES AND THEIR 1-DEAZA ANALOGS IMIDAZO[1,2-A]QUINOXALINES AT THE BENZODIAZEPINE RECEPTOR.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 37, pp. 2846-2850, ISSN:0022-2623

V. COLOTTA; L. CECCHI; D. CATARZI; G.FILACCHIONI; A. GALLI; F. MORI (1994). SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF 1-AMINOPHTHALAZINIUM SALTS AS GABAA RECEPTOR ANTAGONISTS.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 29, pp. 95-105, ISSN:0223-5234

D. CATARZI; L. CECCHI; V. COLOTTA;G.FILACCHIONI; C. MARTINI; L. GIUSTI; A. LUCACCHINI; G. VALLE (1994). TRICYCLIC HETEROAROMATIC SYSTEMS. 2-PHENYL-1,2,4-TRIAZOLO[1,5-C][1,3]BENZOXAZIN-5-ONE: A NOVEL BENZODIAZEPINE RECEPTOR LIGAND.. IL FARMACO, vol. 49, pp. 89-92, ISSN:0014-827X

C.COLOTTA; L. CECCHI; D.CATARZI; F.MELANI; G. FILACCHIONI; C. MARTINI; P.TACCHI; A. LUCACCHINI; (1993). NOVEL ADENOSINE RECEPTOR LIGANDS: 1,3-DISUBSTITUTED[1]BENZOPYRANO[2,3-C]PYRAZOL-4-ONES. SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS.. RECEPTORS & CHANNELS, vol. 1, pp. 111-119, ISSN:1060-6823

D. Catarzi; L.Cecchi; G.Filacchioni; A. Bartolini; R.Carpenedo; A. Galli; F.Mori (1993). Synthesis and structure-activity relationships of 1-aminophthalazinium bromides as GABAA receptor ligands.. DRUG DESIGN AND DISCOVERY, vol. 10, pp. 23-34, ISSN:1055-9612

V. COLOTTA; L. CECCHI; D. CATARZI; G.CONTI; G. FILACCHIONI; C.MARTINI; L. GIUSTI; A. LUCACCHINI; (1993). TRICYCLIC HETEROAROMATIC SYSTEMS PYRAZOLO[1,5-A]QUINOXALINES: SYNTHESIS AND BENZODIAZEPINE RECEPTOR ACTIVITY.. IL FARMACO, vol. 48, pp. 1051-1063, ISSN:0014-827X

D.CATARZI; L. CECCHI; V.COLOTTA; F.MELANI; G. FILACCHIONI; C. MARTINI; L.GIUSTI; A. LUCACCHINI (1993). TRICYCLIC HETEROAROMATIC SYSTEMS 1,2,4-TRIAZOLO[1,5-A]QUINOXALINES: SYNTHESIS AND BENZODIAZEPINE RECEPTOR ACTIVITY.. IL FARMACO, vol. 48, pp. 1065-1078, ISSN:0014-827X

D.CATARZI; L. CECCHI; V.COLOTTA; G.CONTI; F.MELANI; G. FILACCHIONI; C. MARTINI; L. GIUSTI; A.LUCACCHINI (1993). REACTION OF 1-AMINOPHTHALAZINES WITH A-HALOCARBONYL COMPOUNDS: IMIDAZO-2,1-A]PHTHALAZINES AND THEIR BENZODIAZEPINE RECEPTOR ACTIVITIES.. IL FARMACO, vol. 48, pp. 447-457, ISSN:0014-827X

D. CATARZI; L. CECCHI; V. COLOTTA; G.FILACCHIONI; F. MELANI (1992). TRICYCLIC HETEROAROMATIC SYSTEMS. 1,2,4-TRIAZOLO[1,5-A]QUINOXALINE.. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 29, pp. 1161-1163, ISSN:0022-152X

L. Cecchi; V. Colotta; D. Catarzi; F. Melani; G. Filacchioni; C. Martini; P. Tacchi; A. Lucacchini (1992). Synthesis and structure-activity relationships on 1,3-disubstituted [1]benzopyrano[2,3-c]pyrazol-4-ones, a new class of adenosine receptor antagonists. In: XXII International Symposium on Medicinal Chemistry, Basel, Switzerland, 13-17 September 1992, d, pp. 284-284.

V. Colotta; D. Catarzi; L. Cecchi; Gabriele Conti; F. Melani; G. Filacchioni; A. Lucacchini C. Martini (1992). Structure-activity relationships on rigid benzodiazepine receptor ligands. In: XVII Congresso Nazionale della Divisione di Chimica Farmaceutica della SCI, Genova, 25-30 Ottobre 1992, d, pp. 54-55.

V.Colotta; L.Cecchi; D.Catarzi; F.Melani; G.Filacchioni; C.Martini; P.Tacchi; A.Lucacchini (1992). 1-(3-Aminophenyl)-3-methyl[1]benzopyrano[2,3-c]pyrazol-4-one: a new selective A2 adenosine receptor antagonist.. PHARMACEUTICAL AND PHARMACOLOGICAL LETTERS, vol. 2, pp. 74-76, ISSN:0939-9488

F.MELANI; L. CECCHI; V. COLOTTA; D. CATARZI; G.FILACCHIONI (1992). TRICYCLIC HETEROAROMATIC SYSTEMS. 5H-1,2,4-TRIAZOLO[5,1-C][1,4]BENZODIAZEPINE.. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 29, pp. 819-823, ISSN:0022-152X

V.Colotta; L.Cecchi; F.Melani; D.Catarzi; G.Filacchioni; C.Martini; G.Giannaccini; M.Tonelli; A.Lucacchini (1992). Tricyclic heteroaromatic systems. Synthesis and benzodiazepine binding activity of 1-substituted-3-methyl- and 3-phenylpyrazolo[4,5-c]quinolin-4-ones.. DRUG DESIGN AND DISCOVERY, vol. 8, pp. 325-339, ISSN:1055-9612

D. Catarzi; L. Cecchi; V. Colotta; F. Melani; G. Filacchioni; P. Tacchi; M. Tonelli; C. Martini. (1991). Tricyclic heteroaromatic systems. Synthesis and adenosine receptor binding evaluation of some pyrazolo-quinoline and [1]benzopyrano-pyrazole derivatives. INTERNATIONAL JOURNAL OF PURINE & PYRIMIDINE RESEARCH, vol. 2, pp. 113-121, ISSN:1120-6918

F. Melani; L. Cecchi; V. Colotta; D. Catarzi; G. Filacchioni. (1991). Qualitative requirements for rigid benzodiazepine receptor ligands. In: X Congresso Nazionale della Divisione di Chimica Farmaceutica della SCI, Siena, 16-20 settembre 1991, d, pp. 44-44.

Daniela CATARZI

Biography

1990: Degree in Pharmaceutical Chemistry and Technology, University of Florence (110 with honour)
1993: PhD in Medicinal Chemistry, University of Florence
1995-1998: Technical Assistant-VI Level, Department of Pharmaceutical Sciences, University of Florence
1998-2015: Assistant Professor in Medicinal Chemistry (SSD CHIM/08), Department of NEUROFARBA - Section of Pharmaceutics and Nutraceutics (former Department of Pharmaceutical Sciences), University of Florence
From 2015: Associate Professor in Medicinal Chemistry (SSD CHIM/08 now CHEM-07/A), Department of NEUROFARBA - Section of Pharmaceutics and Nutraceutics (former Department of Pharmaceutical Sciences), University of Florence

Daniela CATARZI

Curriculum

The RESEARCH ACTIVITY of Daniela Catarzi takes place in the field Early of Medicinal Chemistry. Early studies focused on the identification of benzodiazepine receptor ligands and GABAA receptor antagonists. In recent years, her attention has been directed toward the development of adenosine receptor ligands, carbonic anhydrase modulators, kinase (CK2, CK1delta) and CD73 inhibitors which represent possible new therapeutical strategies for the treatment of neurodegenerative diseases and cancer. Particular interest is devoted to the design and synthesis of hybrid molecules as innovative therapeutic agents for a polypharmacological approach.

WORK EXPERIENCE

From 2015 to the present	Associate Professor at the University of Florence (CHIM/08 – Medicinal Chemistry)

	▪ Main activities and responsability: teaching and research Sector: Medicinal Chemistry
From 1998 to 2015	Researcher at the University of Florence (CHIM/08 – Medicinal Chemistry)
	Faculty of Pharmacy, then Dept. of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA) - Section of Pharmaceutical and Nutraceutical Sciences
	▪ Main activities and responsability: teaching and research ▪ Sector: Medicinal Chemistry
From 1995 to 1998	Technical assistant at the University of Florence

	▪ Management and maintenance of NMR spectrometer and instruments of medicinal chemistry lab. Assistant to the activities in the teaching laboratories of the Faculty of Pharmacy.
From 1993 to 1994	Research Fellow in medicinal chemistry at the University of Florence
From 1993 to 1994
1990	Research Fellow in medicinal chemistry at the University of Florence
1990
From 1990 to the present	Main activities and responsabilities
From 1990 to the present	▪ Research activities: Design and synthesis of benzodiazepine receptor ligands, GABAA and glutamate receptor antagonists, adenosine receptor ligands, carbonic anhydrase modulators, kinase and CD73 inhibitors. Identification of new therapeutic strategies for the treatment of neurodegenerative diseases and cancer. Teaching activity: From 2000 to the present, teacher in the degree course of Chemistry and Pharmaceutical Technology. To date, Scientific tutor of three PhD thesis in Medicinal Chemistry and supervisor or co-supervisor of more than 50 degree theses in Pharmacy, and Pharmaceutical Chemistry and Technology. Academic responsabilities: From 2016 to present,Guidance Delegate of the School of Human Health Sciences at the University of Florence (organization and management of university choice orientation events). Editoral activity: From 2018 to present, Guest Editor and Editorial Board Member of Pharmaceuticals (Open Access Journal MDPI), I.F. 5.86. Publications: 100 in peer review journals; 2 international patent, H-index=31; number of citations=2437 (SCOPUS).

EDUCATION AND TRAINING

2012	National Qualification (ASN) as Associate Professor in Medicinal Chemistry (03/D1)
From 1990 to 1993	PhD in Pharmaceutical Chemistry
	University of Florence (Italy)
	▪ Design, synthesis, purification and structural characterization of heterocyclic compounds as benzodiazepine receptor ligands.
1990	Degree in Pharmaceutical Chemistry and Technology (110 and honours)
1990	University of Florence (Italy)

Daniela CATARZI

Interest

The research activity focuses on the synthesis and structural characterization of new small molecules designed to target biological proteins involved in high social impact pathologies, and to identify new therapeutic approaches. In particular, attention is directed towards the development of adenosine receptor ligands, carbonic anhydrase modulators, inhibitors of casein kinase 1δ and CD73, which represent possible new therapeutic agents for the treatment of cancer and neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis.

A part of the research is devoted to the design and synthesis of multitarget molecules to explore their potential as innovative polypharmacological agents for multifactorial pathologies. Particular attention is paid to evaluating and implementing green strategies for the synthesis and purification of the target compounds.