Gabriella GUERRINI

Ruolo attuale:: Ricercatore
SSD:: CHEM-07/A - Chimica farmaceutica
Afferenza organizzativa:: Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino (NEUROFARBA)

Recapiti

	0554573766
	gabriella.guerrini(AT)unifi.it

Avvisi

CORSO ANALISI DEI MEDICINALI II (A-L, Prof. Guerrini Gabriella )

Gli studenti del corso di AMII (partizione A-L, ordinamento B054 e B264) sono PREGATI di iscriversi al laboratorio (dalla propria pagina SOL) e anche sulla piattaforma moodle: B029428 (B264) - ANALISI DEI MEDICINALI II - COGNOMI A-L 2024-2025.

Gabriella GUERRINI

Orario di ricevimento (aggiornato al 13/03/2025)

contattare il docente per e-mail (gabriella.guerrini@unifi.it) o telefono (055-4573766)

Gabriella GUERRINI

Curriculum

1989: Laurea in Chimica e Tecnologia Farmaceutiche presso l'Università degli Studi di Firenze. Abilitazione all’esercizio della professione di Farmacista.

1991-2001: tecnico presso la Facoltà di Farmacia dell'Università degli Studi di Firenze, Dipartimento di Scienze Farmaceutiche

1991 ad oggi: svolge assistenza alle esercitazioni del corso di "Laboratorio di Preparazione Estrattiva e Sintetica dei Farmaci" del Corso di Laurea Specialistica in CTF.

2001 ad oggi: Ricercatore presso la Facoltà di Farmacia dell'Università degli Studi di Firenze, Dipartimento di Scienze Farmaceutiche.

2001 ad oggi: svolge un modulo nell'ambito del corso di "Laboratorio di Preparazione Estrattiva e Sintetica dei Farmaci" del Corso di Laurea Specialistica in CTF.

2006-2008: ha svolto un modulo nell'ambito del corso di "Complementi di Chimica Farmaceutica” della Scuola di Specializzazione in Farmacia Ospedaliera.

2005-2009: ha avuto in affidamento il corso di "Laboratorio di Preparazione Estrattiva" del Corso di Laurea in Tecniche Erboristiche.

2009-2011: ha avuto in affidamento il corso di "Laboratorio di Preparazione Estrattiva" del Corso di Studio in Scienze Farmaceutiche Applicate, indirizzo Tecniche Erboristiche.

2013-2014: svolge un modulo di laboratorio nell'ambito del corso di "Analisi dei Medicinali III" del Corso di Studio in Farmacia

2015 ad oggi: ha in affidamento il corso di Analisi dei Medicinali II (Analisi dei Medicinali III, Vecchio Ordinamento) per il CdS di Farmacia.

Gabriella GUERRINI

Interessi

Sintesi di composti azotati policondensati contenenti il nucleo pirazolico come ligandi al recettore benzodiazepinico centrale (CBR), periferico (PBR), per lo studio di patologie tumorali e neurodegenerative.

Gabriella GUERRINI

Pubblicazioni

Legenda

Contributo su rivista |

Articolo su libro |

Libro |

Contributo in atti di convegno (proceeding) |

Brevetto |

Curatela | Altro

Altro |

Tesi di Dottorato

Crocetti, Letizia; Pearce, Abigail; Vege, Venkat S.; Xu, Qi; Xu, Jing; Buthmann, Hannes; Giovannoni, Maria Paola; Guerrini, Gabriella; Catarzi, Francesca; Selleri, Silvia; Huang, Xianglin; Chandran, Aneesh; Ladds, Graham; Cilibrizzi, Agostino (2025). New heterocyclic A1/A3 adenosine receptor ligands through molecular simplification strategies. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY REPORTS, vol. 13, pp. 0-0, ISSN:2772-4174 DOI

Crocetti, Letizia; Catarzi, Francesca; Giovannoni, Maria Paola; Vergelli, Claudia; Bartolucci, Gianluca; Pallecchi, Marco; Paoli, Paola; Rossi, Patrizia; Lippi, Martina; Schepetkin, Igor A.; Quinn, Mark T.; Guerrini, Gabriella (2024). Ebselen analogues with dual human neutrophil elastase (HNE) inhibitory and antiradical activity. RSC MEDICINAL CHEMISTRY, pp. 1-11, ISSN:2632-8682 DOI

Crocetti, Letizia; Guerrini, Gabriella; Melani, Fabrizio; Mascia, Maria Paola; Giovannoni, Maria Paola (2024). 3,8-Disubstituted Pyrazolo[1,5-a]quinazoline as GABAA Receptor Modulators: Synthesis, Electrophysiological Assays, and Molecular Modelling Studies. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 25, pp. 1-23, ISSN:1422-0067 DOI

Crocetti, Letizia; Khlebnikov, Andrei I.; Guerrini, Gabriella; Schepetkin, Igor A.; Melani, Fabrizio; Giovannoni, Maria Paola; Quinn, Mark T. (2024). Anti-Inflammatory Activity of Pyrazolo[1,5-a]quinazolines. MOLECULES, vol. 29, pp. 1-24, ISSN:1420-3049 DOI

Guerrini, Gabriella; Giovannoni, Maria Paola (2024). Ion Channels as a Therapeutic Target: Drug Design and Pharmacological Investigation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 25, pp. 1-4, ISSN:1422-0067 DOI

Crocetti, Letizia; Giovannoni, Maria Paola; Vergelli, Claudia; Guerrini, Gabriella; Melani, Fabrizio; Cilibrizzi, Agostino (2024). New quinoline-based PDE4 inhibitors through GSK-256066 fragment-based elaboration. JOURNAL OF MOLECULAR STRUCTURE, vol. 1295, pp. 136719-136734, ISSN:0022-2860 DOI Accesso ONLINE all'editore

Crocetti, Letizia; Guerrini, Gabriella; Melani, Fabrizio; Vergelli, Claudia; Giovannoni, Maria Paola (2023). 4,5-Dihydro-5-Oxo-Pyrazolo[1,5-a]Thieno[2,3-c]Pyrimidine: A Novel Scaffold Containing Thiophene Ring. Chemical Reactivity and In Silico Studies to Predict the Profile to GABAA Receptor Subtype. MOLECULES, vol. 28, pp. 3054-3074, ISSN:1420-3049 DOI

Crocetti, Letizia; Giovannoni, Maria Paola; Guerrini, Gabriella; Lamanna, Silvia; Melani, Fabrizio; Bartolucci, Gian Luca; Pallecchi, Marco; Paoli, Paola; Lippi, Martina; Wang, Junjie; Dahl, Gerhard (2023). Design, Synthesis and Pharmacological Evaluation of New Quinoline-Based Panx-1 Channel Blockers. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 24, pp. 1-23, ISSN:1422-0067 DOI Accesso ONLINE all'editore

Crocetti, Letizia; Guerrini, Gabriella; Giovannoni, Maria Paola; Melani, Fabrizio; Lamanna, Silvia; Di Cesare Mannelli, Lorenzo; Lucarini, Elena; Ghelardini, Carla; Wang, Junjie; Dahl, Gerhard (2022). New Panx-1 Blockers: Synthesis, Biological Evaluation and Molecular Dynamic Studies. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, pp. 4827-4855, ISSN:1422-0067 DOI

Letizia Crocetti, Gabriella Guerrini, Fabrizio Melani, Claudia Vergelli, Maria Paola Giovannoni, Maria Paola Mascia (2022). GABAA receptor modulators with a pyrazolo[1,5-a]quinazoline core: synthesis, molecular modelling studies and electrophysiological assay. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, pp. 13032-13051, ISSN:1422-0067 DOI

Letizia Crocetti, Gabriella Guerrini, Claudia Vergelli, Maria Paola Giovannoni, Gian Luca Bartolucci, Silvia Lamanna, Marco Pallecchi, Paola Paoli, Patrizia Rossi (2022). Molecular manipulation of the 1,5,6,7-tetrahydro-4 H -indazol-4-one scaffold to obtain new human neutrophil elastase (HNE) inhibitors. JOURNAL OF MOLECULAR STRUCTURE, vol. 1263, pp. 133140-133154, ISSN:0022-2860 DOI Accesso ONLINE all'editore

Vergelli C.; Khlebnikov A.I.; Crocetti L.; Guerrini G.; Cantini N.; Kirpotina L.N.; Schepetkin I.A.; Cilibrizzi A.; Quinn M.T.; Rossi P.; Paoli P.; Giovannoni M.P. (2021). Synthesis, biological evaluation, molecular modeling, and structural analysis of new pyrazole and pyrazolone derivatives as N-formyl peptide receptors agonists. CHEMICAL BIOLOGY & DRUG DESIGN, vol. 98, pp. 582-603, ISSN:1747-0277 DOI

Crocetti, Letizia; Vergelli, Claudia; Guerrini, Gabriella; Giovannoni, Maria Paola; Kirpotina, Liliya N.; Khlebnikov, Andrei I.; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo; Lucarini, Elena; Schepetkin, Igor A.; Quinn, Mark T. (2021). Pyridinone Derivatives as Interesting Formyl Peptide Receptor (FPR) Agonists for the Treatment of Rheumatoid Arthritis. MOLECULES, vol. 26, pp. 6583-6583, ISSN:1420-3049 DOI Accesso ONLINE all'editore

Cantini, Niccolò; Khlebnikov, Andrei I.; Crocetti, Letizia; Schepetkin, Igor A.; Floresta, Giuseppe; Guerrini, Gabriella; Vergelli, Claudia; Bartolucci, Gianluca; Quinn, Mark T.; Paola Giovannoni, Maria (2021). Exploration of Nitrogen Heterocycle Scaffolds for the Development of Potent Human Neutrophil Elastase Inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 29, pp. 1-17, ISSN:0968-0896 DOI

Crocetti, Letizia; Guerrini, Gabriella; Puglioli, Sara; Giovannoni, Maria Paola; Di Cesare Mannelli, Lorenzo; Lucarini, Elena; Ghelardini, Carla; Wang, Junjie; Dahl, Gerhard (2021). Design and synthesis of the first indole-based blockers of Panx-1 channel. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 223, pp. 113650-113660, ISSN:0223-5234 DOI

Cantini, Niccolo; Crocetti, Letizia; Guerrini, Gabriella; Vergelli, Claudia; Schepetkin, Igor A; Pallecchi, Marco; Bartolucci, Gian Luca; Quinn, Mark T; Teodori, Elisabetta; Paola Giovannoni, Maria (2021). 1,5,6,7-Tetrahydro-4H-indazol-4-ones as human neutrophil elastase (HNE) inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 52, pp. 128380-128386, ISSN:0960-894X DOI

Crocetti, Letizia; Guerrini, Gabriella; Cantini, Niccolò; Vergelli, Claudia; Melani, Fabrizio; Mascia, Maria Paola; Giovannoni, Maria Paola (2021). 'Proximity frequencies' a new parameter to evaluate the profile of GABAAR modulators. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 34, pp. 127755-127762, ISSN:0960-894X DOI

Rossi P.; Ceccarelli J.; Milazzo S.; Paoli P.; Morais Missina J.; Ciattini S.; Ienco A.; Tuci G.; Valleri M.; Giovannoni M.P.; Guerrini G.; Conti L. (2021). Nonsteroidal Anti-Inflammatory Drugs-1-Phenylethylamine Diastereomeric Salts: A Systematic Solid-State Investigation. CRYSTAL GROWTH & DESIGN, vol. 21, pp. 6947-6960, ISSN:1528-7483 DOI Accesso ONLINE all'editore

Crocetti L.; Giovannoni M.P.; Cantini N.; Guerrini G.; Vergelli C.; Schepetkin I.A.; Khlebnikov A.I.; Quinn M.T. (2020). Novel Sulfonamide Analogs of Sivelestat as Potent Human Neutrophil Elastase Inhibitors. FRONTIERS IN CHEMISTRY, vol. 8, pp. 795-811, ISSN:2296-2646 DOI

Crocetti L.; Vergelli C.; Guerrini G.; Cantini N.; Kirpotina L.N.; Schepetkin I.A.; Quinn M.T.; Parisio C.; Di Cesare Mannelli L.; Ghelardini C.; Giovannoni M.P. (2020). Novel formyl peptide receptor (FPR) agonists with pyridinone and pyrimidindione scaffolds that are potentially useful for the treatment of rheumatoid arthritis. BIOORGANIC CHEMISTRY, vol. 100, pp. 1-12, ISSN:0045-2068 DOI

Crocetti, Letizia; Guerrini, Gabriella (2020). GABAA receptor subtype modulators in medicinal chemistry: an updated patent review (2014-present). EXPERT OPINION ON THERAPEUTIC PATENTS, vol. .., pp. 1-24, ISSN:1354-3776 DOI Accesso ONLINE all'editore

Maria Paola Giovannoni, Letizia Crocetti, Niccolò Cantini, Gabriella Guerrini, Claudia Vergelli, Antonella Iacovone, Elisabetta Teodori, Igor A. Schepetkin, Mark T. Quinn, Samuele Ciattini,Patrizia Rossi, Paola Paoli (2020). New 3-unsubstituted Isoxazolones as Potent Human Neutrophil Elastase Inhibitors: Synthesis and Molecular Dynamic Simulation. DRUG DEVELOPMENT RESEARCH, vol. 81, pp. 338-349, ISSN:1098-2299 DOI Accesso ONLINE all'editore

Rossi P.; Paoli P.; Milazzo S.; Chelazzi L.; Giovannoni M.P.; Guerrini G.; Ienco A.; Valleri M.; Conti L. (2020). A combined crystallographic and computational study on dexketoprofen trometamol dihydrate salt. CRYSTALS, vol. 10, pp. 1-14, ISSN:2073-4352 DOI

Gabriella Guerrini, Letizia Crocetti, Simona Daniele, Antonella Iacovone, Niccolò Cantini,Claudia Martini, Fabrizio Melani, Claudia Vergelli, Maria Paola Giovannoni, (2019). New 3,6-disubstituted pyrazolo[1,5-a]quinazolines as ligands to GABAA receptor subtype. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 56, pp. 1571-1580, ISSN:1943-5193 DOI

Giovannoni M.P.; Cantini N.; Crocetti L.; Guerrini G.; Iacovone A.; Schepetkin I.A.; Vergelli C.; Khlebnikov A.I.; Quinn M.T. (2019). Further modifications of 1H-pyrrolo[2,3-b]pyridine derivatives as inhibitors of human neutrophil elastase. DRUG DEVELOPMENT RESEARCH, vol. 2019, pp. 1-12, ISSN:0272-4391 DOI Accesso ONLINE all'editore

Guerrini, Gabriella; Vergelli, Claudia; Cantini, Niccolò; Giovannoni, Maria; Daniele, Simona; Mascia, Maria Paola; Martini, Claudia; Crocetti, Letizia (2019). Synthesis of New GABAA Receptor Modulator with Pyrazolo[1,5-a]quinazoline (PQ) Scaffold. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 20, pp. 1438-1457, ISSN:1422-0067 DOI

Letizia Crocetti, Maria Paola Giovannoni, Igor A. Schepetkinb, Mark T. Quinn, Andrei I. Khlebnikovc, Niccolò Cantini, Gabriella Guerrini, Antonella Iacovone, Elisabetta Teodori, Claudia Vergelli (2018). 1H-pyrrolo[2,3-b]pyridine: a new scaffold for human neutrophil elastase (HNE) inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 26, pp. 5583-5595, ISSN:0968-0896 DOI

Giovannoni, Maria Paola; Schepetkin, Igor A.; Quinn, Mark T.; Cantini, Niccolò; Crocetti, Letizia*; Guerrini, Gabriella; Iacovone, Antonella; Paoli, Paola; Rossi, Patrizia; Bartolucci, Gian Luca; Menicatti, Marta; Vergelli, Claudia (2018). Synthesis, biological evaluation, and molecular modelling studies of potent human neutrophil elastase (HNE) inhibitors. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 33, pp. 1108-1124, ISSN:1475-6366 DOI

Gabriella Guerrini, Giovanna Ciciani, Simona Daniele, Claudia Martini, Camilla Costagli, Chiara Guarino, Silvia Selleri (2018). A new class of pyrazolo[5,1-c][1,2,4]triazines as γ-aminobutyric type A (GABAA) receptor subtype ligand: synthesis and pharmacological evaluation. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 26, pp. 2475-2487, ISSN:0968-0896 DOI

Guerrini, Gabriella; Ciciani, Giovanna; Crocetti, Letizia; Daniele, Simona; Ghelardini, Carla; Giovannoni, MARIA PAOLA; Iacovone, Antonella; DI CESARE MANNELLI, Lorenzo; Martini, Claudia; Vergelli, Claudia (2017). Identification of a new pyrazolo[1,5-a]quinazoline ligand highly affine to γ-aminobutyric type A (GABAA) receptor subtype with anxiolytic-like and antihyperalgesic activity. JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, pp. 9691-9702, ISSN:0022-2623 DOI

Vergelli, C; Schepetkin, I. A.; Crocetti, L.; Iacovone, A.; Giovannoni, M. P.; Guerrini, G.; Khlebnikov, A. I.; Ciattini, S.; Ciciani, G.; Quinn, M. T. (2017). Isoxazolo-5(2H)-one: a new scaffold for potent human neutrophil elastase (HNE) inhibitors. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 32, pp. 821-831, ISSN:1475-6366 DOI

Gabriella, Guerrini; Ciciani, Giovanna; Daniele, Simona; lorenzo di cesare mannelli, ; Ghelardini, Carla; Martini, Claudia; Silvia, Selleri (2017). Synthesis and pharmacological evaluation of pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives as potential GABAA-R ligands. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 25, pp. 1901-1906, ISSN:0968-0896 DOI

Crocetti, Letizia; Bartolucci Gian Luca, ; Cilibrizzi, Agostino; Giovannoni, Maria Paola; Guerrini, Gabriella; Iacovone, Antonella; Menicatti, Marta; Schepetkin, Igor A; Khlebnikov, Andrei I; Quinn, Mark T; Vergelli, Claudia (2017). Synthesis and analytical characterization of new thiazol-2-(3H)-ones as human neutrophil elastase (HNE) inhibitors. CHEMISTRY CENTRAL JOURNAL, vol. 11, pp. 127-141, ISSN:1752-153X DOI

Guerrini, Gabriella; Ciciani, Giovanna; Crocetti, Letizia; Daniele, Simona; Ghelardini, Carla; Giovannoni, Maria Paola; Lorenzo Di Cesare Mannelli, ; Martini, Claudia; Vergelli, Claudia (2017). Synthesis and pharmacological evaluation of novel GABAA subtype receptor ligands with potential anxiolytic-like and anti-hyperlagesic effect. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 54, pp. 2788-2799, ISSN:1943-5193 DOI

Vergelli, Claudia; Schepetkin, Igor A.; Ciciani, Giovanna; Cilibrizzi, Agostino; Crocetti, Letizia; Giovannoni, Maria Paola; Guerrini, Gabriella; Iacovone, Antonella; Kirpotina, Liliya N.; Ye, Richard D.; Quinn, Mark T. (2017). Synthesis of five and six-membered N-phenylacetamido substituted heterocycles as formyl peptide receptor agonists. DRUG DEVELOPMENT RESEARCH, vol. 78, pp. 49-62, ISSN:1098-2299 DOI

Crocetti, Letizia; Schepetkin, Igor A.; Ciciani, Giovanna; Giovannoni, Maria Paola; Guerrini, Gabriella; Iacovone, Antonella; Khlebnikov, Andrei I.; Kirpotina, Liliya N.; Quinn, Mark T.; Vergelli, Claudia (2016). Synthesis and pharmacological evaluation of indole derivatives as deaza analogues of potent human neutrophil elastase inhibitors. DRUG DEVELOPMENT RESEARCH, vol. 77, pp. 285-299, ISSN:1098-2299 DOI

Giovannoni, Maria Paola; Crocetti, Letizia; Ciciani, Giovanna; Cilibrizzi, Agostino; Guerrini, Gabriella; Vergelli, Claudia (2016). Cinnoline derivatives as human neutrophil elastase inhibitors. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 31, pp. 628-639, ISSN:1475-6366 DOI

Vergelli, C; Schepetkin, I.A; Ciciani, G; Cilibrizzi, A; Crocetti, L; Giovannoni, M.P; Guerrini, G; Iacovone, A; Kirpotina, L.N; Khlebnikov, A.I; Ye, R.D; Quinn, M.T. (2016). 2-Arylacetamido-4-phenylamino-5-substituted pyridazinones as formyl peptide receptors agonists.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 24, pp. 2530-2543, ISSN:0968-0896

Gabriella Guerrini; Giovanna Ciciani; Samuele Ciattini; Letizia Crocetti; Simona Daniele; Claudia Martini; Fabrizio Melani; Claudia Vergelli; Maria Paola Giovannoni (2016). Pyrazolo[1,5-a]quinazoline scaffold as 5-deaza analogue of pyrazolo[5,1-c][1,2,4]benzotriazine system: synthesis of new derivatives, biological activity on GABAA receptor subtype and molecular dynamic study. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 31, pp. 195-204, ISSN:1475-6366 DOI

Claudia Vergelli; Giovanna Ciciani; Agostino Cilibrizzi; Letizia Crocetti; Lorenzo Di Cesare Mannelli; Carla Ghelardini; Gabriella Guerrini; Antonella Iacovone; Maria Paola Giovannoni (2015). Synthesis of five and six-membered heterocycles bearing an arylpiperazinylalkyl side chain as orally active antinociceptive agents. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 23, pp. 6237-6245, ISSN:0968-0896

M. P. Giovannoni;G. Ciciani;A. Cilibrizzi;L. Crocetti;S. Daniele;L. Di Cesare Mannelli;C. Ghelardini;C. Giacomelli;G. Guerrini;C. Martini;M. L. Trincavelli;C. Vergelli (2015). Further studies on pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective human A1 adenosine receptor antagonists.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 89, pp. 32-41, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Gabriella Guerrini; Giovanna Ciciani (2013). Benzodiazepine receptor ligands: a patent review (2006 -- 2012). EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 23, pp. 0843-0866, ISSN:1354-3776 DOI

Gabriella Guerrini; Giovanna Ciciani; Annarella Costanzo; Simona Daniele; Caludia Martini; Carla Ghelardini; Lorenzo Di Cesare Mannelli. (2013). Synthesis of novel cognition enhancer with pyrazolo[5,1-c][1,2,4]benzotriazine core acting at gamma-aminobutyric acid type A (GABAA) receptor.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, pp. 2186-2198, ISSN:1464-3391 DOI

G. Guerrini; G. Ciciani; F. Bruni; S. Selleri; C. Martini; S. Daniele; C. Ghelardini; L. Di Cesare Mannelli; A. Costanzo (2011). Development of ligands at gamma aminobutyrric acid type A (GABAA) receptor subtype as new agent for pain relief.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, pp. 7441-7452, ISSN:1464-3391 DOI

G. Guerrini; G. Ciciani; F. Bruni; S. Selleri; F. Melani; S. Daniele; C. Martini; A. Costanzo (2011). New 3-, 8-disubstituted pyrazolo[5,1-c][1,2,4]benzotriazines useful for studying the interaction with the HBp-3 area (hydrogen bond point area) in the benzodiazepine site on the gamma-aminobutyric acid type A (GABAA) receptor. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, pp. 3074-3085, ISSN:1464-3391 DOI

G. Guerrini; G. Ciciani; F. Bruni; S. Selleri; C. Guarino; F. Melani; M. Montali; S. Daniele; C. Martini; C. Ghelardini; M. Norcini; S. Ciattini; A. Costanzo (2010). New fluoro derivatives of the pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide system: evaluation of fluorine binding properties in the benzodiazepine site on gamma-aminobutyrric acid type A (GABAA) receptor. Design, synthesis, biological evaluation, and molecular modeling investigation.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, pp. 7532-7548, ISSN:1520-4804 DOI

BRUNI, F.; SELLERI, S.; COSTANZO, A.; GUERRINI, G.; CASILLI, M. L. (2010). ChemInform Abstract: Reactivity of 7‐(2‐Dimethylaminovinyl)pyrazolo(1,5‐a)pyrimidines: Synthesis of Pyrazolo(1,5‐a)pyrido(3,4‐e)pyrimidine Derivatives as Potential Benzodiazepine Receptor Ligands. Part 1. CHEM INFORM, vol. 26, pp. 1-1, ISSN:0931-7597 DOI

G. Guerrini; G. Ciciani (2010). gamma-Aminobutyric acid type A (GABAA) receptor subtypes inverse agonists as therapeutic agents in cognition. In: JOHN N. ABELSON AND MELVIN I. SIMON. Constitutive Activity in Receptor and Other Proteins, Part B, pp. 197-211 Elsevier Inc., ISBN:978-0-12-381296-4. DOI

BRUNI, F.; SELLERI, S.; COSTANZO, A.; GUERRINI, G.; CASILLI, M. L.; SACCO, C.; DONATO, R. (2010). ChemInform Abstract: Pyrazolo(1,5‐a)pyrido(3,4‐e)pyrimidin‐6‐ones. Part 1. Synthesis and in vitro Antimicrobial Evaluation. CHEM INFORM, vol. 27, pp. 1-1, ISSN:0931-7597 DOI

G. Guerrini; G. Ciciani; G. Cambi; F. Bruni; S.Selleri; C. Guarino; F. Melani; M. Montali; C: Martini; C. Ghelardini; M. Norcini; A. Costanzo (2009). Synthesis, in vivo evaluation, and molecular modeling studies of new pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide derivatives. Identification of a bifunctional hydrogen bond area related to the inverse-agonism. JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, pp. 4668-4682, ISSN:0022-2623 DOI

S. Chimichi; M. Boccalini; S. Selleri; C. Costagli; G. Guerrini; G. Viola (2008). On the reactivity of 6-acetyl-7-(2-dimethylaminovinyl)pyrazolo[1,5-a]pyrimidines with 1,3- and 1,4-bisnucleophiles. ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 6, pp. 739-744, ISSN:1477-0520 DOI

G. Guerrini; G. Ciciani; G. Cambi; F. Bruni; S. Selleri; F. Melani; M. Montali; C. Martini; C. Ghelardini; M. Norcini; A. Costanzo (2008). Novel 3-aroylpyrazolo[5,1-c][1,2,4] benzotriazines 5-oxides 8-substituted, ligands at GABAA/benzodiazepine receptor complex: synthesis, pharmacological and molecular modelling studies.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, pp. 4471-4489, ISSN:1464-3391 DOI

G. Ciciani; M. Coronnello; G. Guerrini; S.Selleri; M.Cantore; P. Failli; E. Mini; A. Costanzo (2008). Synthesis of new pyrazolo[5,1-c][1,2,4]benzotriazines, pyrazolo[5,1-c]pyrido[4,3-e][1,2,4]triazines and their open analogues as cytotoxic agents in normoxic and hypoxic conditions.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, pp. 9409-9419, ISSN:1464-3391 DOI

G. GUERRINI; G. CICIANI; G. CAMBI; F. BRUNI; S. SELLERI; F. BESNARD; M. MONTALI; C. MARTINI; C. GHELARDINI; N. GALEOTTI; A. COSTANZO (2007). Novel 3-iodo-8-ethoxypyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide as promising lead for design of alpha5-inverse agonist, useful tools for therapy of mnemonic damage.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 15, pp. 2573-2586, ISSN:0968-0896 DOI Accesso ONLINE all'editore

G. GUERRINI; A. COSTANZO; G. CICIANI; F. BRUNI; S. SELLERI; C. COSTAGLI; B. COSTA; C. MARTINI; G. DE SIENA; P. MALMBERG; F. BESNARD (2006). Benzodiazepine receptor ligands. 8. Synthesis and pharamcological evaluation of new pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide 3- and 8-disubstituted: high affinity ligands endowed with inverse-agonist pharmacological efficacy.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 14, pp. 758-775, ISSN:0968-0896 Accesso ONLINE all'editore

S. SELLERI; F. BRUNI; C. COSTAGLI; A. COSTANZO; G. GUERRINI; G. CICIANI; P. GRATTERI; F. BESNARD; B. COSTA; C. MARTINI; G. DE SIENA; P. MALMBERG; M. MONTALI; J. FOHLIN (2005). A novel selective GABA-A alpha1 receptor agonist displaying sedative and anxiolytic-like properties in rodents.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, pp. 6756-6760, ISSN:0022-2623 DOI Accesso ONLINE all'editore

S. SELLERI; P. GRATTERI; C. COSTAGLI; C. BONACCINI; A. COSTANZO; F. MELANI; G. GUERRINI; G. CICIANI; B. COSTA; C. MARTINI; F. BRUNI; F. SPINETTI (2005). Insight into 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl acetamides as Peripheral Benzodiazepine Receptor Ligands: synthesis, biological evaluation and 3D-QSAR investigation.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 13, pp. 4821-4834, ISSN:0968-0896 DOI Accesso ONLINE all'editore

M. CORONNELLO; G. CICIANI; E. MINI; G. GUERRINI; B. CACIAGLI; S. SELLERI; A. COSTANZO; T. MAZZEI (2005). Cytotoxic activity of 3-nitropyrazolo[5,1-c][1,2,4]benzotriazine derivatives: a new series of anti-proliferative agents.. ANTI-CANCER DRUGS, vol. 16, pp. 645-651, ISSN:0959-4973 DOI

S. SELLERI; F. BRUNI; C. COSTAGLI; A. COSTANZO; G. GUERRINI; G. CICIANI; P.GRATTERI; C.BONACCINI; P.MALMBERG AIELLO; F.BESNARD; S.RENARD; B. COSTA; C. MARTINI (2003). Synthesis and Benzodiazepine Receptor Affinity of Pyrazolo [1,5-a]pyrimidine Derivatives.3. New 6-(3-Thienyl) Series as a1 Selective Ligands. JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, pp. 310-313, ISSN:0022-2623 DOI Accesso ONLINE all'editore

A. COSTANZO; G. GUERRINI; G. CICIANI; F. BRUNI; C. COSTAGLI; S. SELLERI; B. COSTA; C. MARTINI; P. MALMBERG AIELLO (2002). Synthesis and pharmacological evaluation of 3-(2-furyl)- and 3-(3-furyl)-(-chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides, new 3-heteroaryl substituted benzodiazepine receptor ligands.. MEDICINAL CHEMISTRY RESEARCH, vol. 11, pp. 87-101, ISSN:1054-2523

F. BRUNI; P. MALMBERG; A. COSTANZO; G. CICIANI; G. GUERRINI; S. SELLERI; C. COSTAGLI; C. MARTINI; B. COSTA; F. BESNARD (2002). BENZODIAZEPINE RECEPTOR LIGANDS. 7. SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF NEW 3-ESTERS OF THE 8-CHLOROPYRAZOLO[5,1-C][1,2,4]BENZOTRIAZINE 5-OXIDE. 3-(2- THIENYLMETHOXYCARBONYL) DERIVATIVE: AN ANXIOSELECTIVE AGENT IN RODENTS.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 45, pp. 5710-5720, ISSN:0022-2623 DOI

S. SELLERI; F. BRUNI; C. COSTAGLI; A. COSTANZO; G. GUERRINI; G. CICIANI; B. COSTA; C. MARTINI (2001). 2-Arylpyrazolo[1,5-a]pyrimidin-3-yl acetamides. New potent and selective Peripheral Benzodiazepine Receptor ligands. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 9, pp. 2661-2671, ISSN:0968-0896

A. COSTANZO; G. GUERRINI; G. CICIANI; F. BRUNI; C. COSTAGLI; S. SELLERI; B. COSTA; C. MARTINI; P. MALMBERG AIELLO (2001). Benzodiazepine receptor ligands. 6. New 3-(2-,3- or 4-substituted benzyloxycarbonyl) derivatives of 8-chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide receptor affinity and In vivo testing C. Martini, P. Malmberg Aiello. MEDICINAL CHEMISTRY RESEARCH, vol. 10, pp. 366-377, ISSN:1054-2523

S. SELLERI; F. BRUNI; C. COSTAGLI; A. COSTANZO; G. GUERRINI; G. CICIANI; P. MALBERG; C. LAMBERTI; B. COSTA; C. MARTINI (2000). Synthesis and BZR affinity of pyrazolo [ 1,5-a ] pyrimidine derivatives. Part 2:Further Investigation on the 3-aryl substituents.. MEDICINAL CHEMISTRY RESEARCH, vol. 10, pp. 92-113, ISSN:1054-2523

S. SELLERI; F. BRUNI; C. COSTAGLI; A. COSTANZO; G. GUERRINI; G. CICIANI; B. COSTA; C. MARTINI (1999). Synthesis, Benzodiazepine receptor affinity of pyrazolo[1,5-a]pyrimidine derivatives. Study of the structural features for BZR recognition- Part I.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 7, pp. 2705-2711, ISSN:0968-0896

G. GUERRINI; A. COSTANZO; F. BRUNI; G. CICIANI; S. SELLERI; P. GRATTERI; B. COSTA; C. MARTINI; A. LUCACCHINI (1999). Benzodiazepine receptor ligands. Part III. Synthesis and biological evaluation of 2 and/or 3-substituted pyrazolo[5,1-c][1,2,4] benzotriazine 5-oxides.. IL FARMACO, vol. 54, pp. 375-389, ISSN:0014-827X

A. COSTANZO; G. GUERRINI; G. CICIANI; F. BRUNI; S. SELLERI; B. COSTA; C. MARTINI; A. LUCACCHINI; P. MALMBERG AIELLO; A. IPPONI (1999). Benzodiazepine receptor ligands. 4.Synthesis, and pharmacological evaluation of 3-hetroaryl-8-chloro pyrazolo[5,1-c][1,2,4] benzotriazine 5-oxides.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, pp. 2218-2226, ISSN:0022-2623

F. BRUNI; S. SELLERI; A. COSTANZO; G. GUERRINI; G. CICIANI; P. LA COLLA; R. DONATO; C. SACCO; C. MUSIU; C. MILIA; S. LONGU; C. MINNEI (1999). Antiproliferative and antimicrobial activities of pyrazolo[5,1-c][1,2,4]benzotriazines 5-oxides and their 5-deoxyderivatives.. MEDICINAL CHEMISTRY RESEARCH, vol. 9, pp. 223-238, ISSN:1054-2523

A. COSTANZO; G. GUERRINI; G. CICIANI; F. BRUNI; S. SELLERI; B. COSTA; C. MARTINI; P. MALMBERG; A. IPPONI; A. LUCACCHINI (1999). BENZODIAZEPINE RECEPTOR (BZR) LIGANDS.5. NEW 3-ALKYLOXYCARBONYL-, 3-CYCLOALKYLOXYCARBONYL-,3-ARYLOXYCARBONYLDERIVATIVES OF PYRAZOLO [5,1-C][1,2,4]BENZOTRIAZINE 5-OXIDES: A STUDY ON THE 3-ESTER FUNCTION MODIFICATION. MEDICINAL CHEMISTRY RESEARCH, vol. 9, pp. 322-339, ISSN:1054-2523

F. BRUNI; A. COSTANZO; G. CICIANI; G. GUERRINI; S. SELLERI; C. MARTINI; A. LUCACCHINI; B. COSTA; S. CAPPELLETTI (1998). BENZODIAZEPINE RECEPTOR LIGANDS. PART II. SYNTHESIS AND BIOLOGICAL EVALUATION OF PYRAZOLO[5,1-C][1,2,4]BENZOTRIAZINES 4-OXIDE.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, pp. 237-244, ISSN:0223-5234

F. BRUNI; S. SELLERI; A. COSTANZO; G. GUERRINI; G. CICIANI; C. COSTAGLI; C. SACCO; R. DONATO (1997). PYRAZOLO[1,5-A]PYRIDO[3,4-E]PYRIMIDN-6-ONES. II. SYNTHESIS AND IN VITRO ANTIMICROBIAL EVALUATION.. IL FARMACO, vol. 52, pp. 639-643, ISSN:0014-827X

S. SELLERI; F. BRUNI; A. COSTANZO; G. GUERRINI; M. CASILLI; L. GIUSTI; A. LUCACCHINI; C. MARTINI; P. MALMBERG; C. LAMBERTI (1997). SYNTHESIS, BENZODIAZEPINE RECEPTOR AFFINITY AND ANTICONVULSANT ACTIVITY OF 3-ARYL-4,7-DIHYDRO-6-(N1'-ALKYLPYRAZOL-3' OR 5'-YL)PYRAZOLO[1,5-A]PYRIMIDIN-7-ONES. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 32, pp. 941-953, ISSN:0223-5234

F. BRUNI; S. SELLERI; A. COSTANZO; G. GUERRINI; M. CASILLI; C. SACCO; R. DONATO (1996). PYRAZOLO[1,5-A]PYRIDO[3,4-E]PYRIMIDIN-6-ONES. I. SYNTHESIS AND IN VITRO ANTIMICROBIAL AND ANTIFUNGAL EVALUATION.. IL FARMACO, vol. 51, pp. 451-455, ISSN:0014-827X

G. GUERRINI; A. COSTANZO; F. BRUNI; S. SELLERI; L. GIUSTI; A. LUCACCHINI; C. MARTINI (1996). BENZODIAZEPINE RECEPTOR LIGANDS. SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF 3-, 7- AND 8-SUBSTITUTED [5,1-C][1,2,4]BENZOTRIAZINES AND 5-OXIDE DERIVATIVES. PART I.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 31, pp. 259-272, ISSN:0223-5234

S. SELLERI; F. BRUNI; A. COSTANZO; G. GUERRINI; M. CASILLI; L. GIUSTI; A. LUCACCHINI; C. MARTINI (1995). NEW 2,3-SUBSTITUTED 4,7-DIHYDRO-6-(1'HPYRAZOL-3'-YL)PYRAZOLO[1,5-A]PYRIMIDI-7-ONES AND RELATED COMPOUNDS: SYNTHESIS AND BENZODIAZEPINE RECEPTOR BINDING STUDY.. IL FARMACO, vol. 50, pp. 679-687, ISSN:0014-827X

F. BRUNI; A. COSTANZO; G. GUERRINI; S. SELLERI; M. CASILLI; L. GIUSTI (1995). REACTIVITY OF 7-(2-DIMETHYLAMINOVINYL)PYRAZOLO[1,5-A]PYRIMIDINES: SYNTHESIS OF PYRAZOLO[1,5-A]PYRIDO[3,4-E]PYRIMIDINE DERIVATIVES AS POTENTIAL BENZODIAZEPINE RECEPTOR LIGANDS. 2.. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 32, pp. 291-298, ISSN:0022-152X

Bruni, Fabrizio, Selleri, Silvia, Costanzo, Annarella, Guerrini, Gabriella, Casilli Lucia, Giusti, Laura (1995). ChemiInform Abstract: reactivity of 7-(2-dimethylaminovinyl)pyrazolo[1,5-a]pyrimidines: synthesis of pyrazolo[1,5-a]pyrido[3,4-e]pyrimidine derivatives as potential benzodiazepine receptor ligands. Part 2. CHEM INFORM, vol. 26, pp. 1-1, ISSN:0931-7597 DOI

A. COSTANZO; G. GUERRINI; F. BRUNI; S. SELLERI (1994). REACTIVITY OF 1-(2-NITROFENIL)-5-AMINOPYRAZOLES UNDER BASIC CONDITIONS AND SYNTHESIS OF NEW 3-, 7-, AND 8-SUBSTITUTED PYRAZOLO[5,1-C][1,2,4]BENZOTRIAZINE 5-OXIDES, AS BENZODIAZEPINE RECEPTOR LIGANDS.JOURNAL OF HETEROCYCLIC CHEMISTRY , - A. COSTANZO, G. GUERRINI, F. BRUNI, S. SELLERI. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 31, pp. 1369-1376, ISSN:0022-152X

F. BRUNI; S. SELLERI; A. COSTANZO; G. GUERRINI; M. CASILLI (1994). REACTIVITY OF 7-(2-DIMETHYLAMINOVINYL) PYRAZOLO[1,5-A]PYRIMIDINES: SYNTHESIS OF PYRAZOLO[1,5-A]PYRIDO[3,4-E]PYRIMIDINE DERIVATIVES AS POTENTIAL BENZODIAZEPINE RECEPTOR LIGANDS.1. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 31, pp. 1193-1198, ISSN:0022-152X

S. CHIMICHI; B. COSIMELLI; F. BRUNI; S. SELLERI; A. COSTANZO; G. GUERRINI; G. VALLE (1994). CHEMISTRY OF SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINES PART 4. A STRUCTURAL CORRECTION OF A SERIES OF PYRAZOLO[5',1':2,3]PYRIMIDO[5,4-D][1,2]DIAZEPINES ON THE BASIS OF NMR SPECTROSCOPY AND X-RAY DIFFRACTION ANALYSIS .. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS II, vol. .., pp. 1657-1660, ISSN:0300-9580

F. BRUNI; A. COSTANZO; S. SELLERI; G. GUERRINI; L. GIUSTI; C. MARTINI; A. LUCACCHINI (1993). SYNTHESIS OF 7-(2-DIMETHYLAMINOVINYL) DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINES, AS PRECURSOR OF NEW TRICYCLIC SERIES. BINDING STUDIES OF BDZ RECEPTOR.. IL FARMACO, vol. 48, pp. 309-319, ISSN:0014-827X

F. BRUNI; A. COSTANZO; S. SELLERI; G. GUERRINI; R. FANTOZZI; R. PIRISINO; S. BRUNELLESCHI (1993). SYNTHESIS AND STUDY OF THE ANTIINFLAMMATORY PROPERTIES OF SOME PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES.. JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 82, pp. 480-486, ISSN:0022-3549

F. BRUNI; B. COSIMELLI; A. COSTANZO; G. GUERRINI; S. SELLERI (1993). 8H-PYRAZOLO[5',1':2,3]PYRIMIDO[5,4-D][1,2]DIAZEPINE. A NEW TRICYCLIC SYSTEM.. HETEROCYCLES, vol. 36, pp. 87-99, ISSN:0385-5414

Costanzo A.; Bruni F.; Guerrini G.; Selleri S.; Aiello P.M.; Lamberti C. (1992). Synthesis of derivatives of pyrazolo[1,5-α]pyrrolo[1,2-c][1,3,6]-benzotriazocine, a new class of compounds with potential cns activity. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 29, pp. 1499-1505, ISSN:1943-5193 Accesso ONLINE all'editore

S. Selleri; F. Bruni; A. Costanzo; G. Guerrini; P. Malmberg Aiello; G. Iavarone; C. Martini (1992). Synthesis and preliminary evaluation of pyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-6(7H)ones and related compounds, as benzodiazepine receptor ligands and anticonvulsant agents.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 27, pp. 985-990, ISSN:0223-5234

F.BRUNI; S. CHIMICHI; B.COSIMELLI; A.COSTANZO; G.GUERRINI; S.SELLERI (1990). Pyrazolo[1,5-a]pyrido[3,4-e]pyrimidine: a New Heterocyclic Ring System. HETEROCYCLES, vol. 31, pp. 1635-1640, ISSN:0385-5414, Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598:

G. Auzzi; A. Costanzo; F. Bruni; M. Clauser; G. Guerrini; S. Selleri; L. Pecori Vettori (1990). Synthesis of 3-(1,3,4-thiadiazol-2-yl)pyrazolo[1,5-a]pyrimidine derivatives as potential antimicrobial agents.. IL FARMACO, vol. 45, pp. 1193-1205, ISSN:0014-827X

F.BRUNI; S. CHIMICHI; B.COSIMELLI; A.COSTANZO; G.GUERRINI; S.SELLERI (1990). A New Entry to Pyrazolo[1,5-a]pyrido[3,4-e]pyrimidine Derivatives. HETEROCYCLES, vol. 31, pp. 1141-1149, ISSN:0385-5414, Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598: