_SKIPNAVIGATION
ITA |
ENG
Personale
Recapiti
Pagina Cercachi
Italiano
Curriculum
Pubblicazioni
Insegnamenti
English
Curriculum
Andrea SCOZZAFAVA
Ruolo attuale:
Professore Ordinario Emerito
SSD:
CHIM/03 - Chimica generale ed inorganica
Afferenza organizzativa:
Dipartimento di Chimica 'Ugo Schiff' - DICUS
Recapiti
0554573273 - 0554573375
andrea.scozzafava(AT)unifi.it
Andrea SCOZZAFAVA
Curriculum
Professore ordinario di chimica generale ed inorganica alla Facolta' di Farmacia dell'Universita'di Firenze e' autore di oltre 550 pubblicazioni su riviste internazionali nei seguenti settori 1) caratterizzazione strutturale e spettroscopica di composti di coordinazione 2) studio della relazione struttura-funzione in metalloenzimi 3) isolamento e caratterizzazione di enzimi coinvolti nella biodegradazione di composti aromatici 4) sintesi di inibitori di metalloenzimi di potenziale interesse farmaceutico. Ha tenuto numerose session lectures a congressi internazionali e numerose conferenze presso universita' italiane e straniere. Ha organizzato nel 1995 a Lviv (Ucraina) un NATO-ASI workshop dal titolo biotechnological remediation of contaminated sites. E'stato ed e' titolare di numerosi contratti di ricerca con il CNR (progetti finalizzati sui rischi industriali e in biotecnologie) e con l'Unione Europea (due progetti Copernicus sulla bioremediazione di siti inquinati da idrocarburi, una rete di ricerca TMR sui metalloenzimi contenenti ferro non eme ,un progetto integrato sull'identificazione delle risposte metaboliche alla carenza di ossigeno nelle cellule tumorali,uno specific targeted research project su un approccio integrato per la realizzazione di nuovi farmaci aventi come target zinco enzimi) ed infine di un progetto della Regione Toscana sulla bioremediazione delle acque reflue dell'industria tessile.
Andrea SCOZZAFAVA
Pubblicazioni
Legenda
Contributo su rivista |
Articolo su libro |
Libro |
Contributo in atti di convegno (proceeding) |
Brevetto |
Curatela |
Altro |
Tesi di Dottorato
Palli L.; Tilli S.; Gregorio S.D.; Scozzafava A.; Gori R. (2020). Treatment of NSAPs-rich petrochemical wastewaters using a two-stage combined process of fungi and activated sludge. ENVIRONMENTAL TECHNOLOGY, pp. 1-14-14, ISSN:0959-3330
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Ferraroni, Marta*; Gaspari, Roberto; Scozzafava, Andrea; Cavalli, Andrea; Supuran, Claudiu T. (2018). Dioxygen, an unexpected carbonic anhydrase ligand. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 33, pp. 999-1005, ISSN:1475-6366
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Ferraroni, Marta; Cornelio, Benedetta; Sapi, Janos; Supuran, Claudiu T.; Scozzafava, Andrea (2018). Sulfonamide carbonic anhydrase inhibitors: Zinc coordination and tail effects influence inhibitory efficacy and selectivity for different isoforms. INORGANICA CHIMICA ACTA, vol. 470, pp. 128-132, ISSN:0020-1693
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Akgul, Ozlem; Di Cesare Mannelli, Lorenzo; Vullo, Daniela; Angeli, Andrea; Ghelardini, Carla; Bartolucci, Gianluca; Altamimi, Abdulmalik Saleh Alfawaz; Scozzafava, Andrea; Supuran, Claudiu T; Carta, Fabrizio (2018). Discovery of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Management of Rheumatoid Arthritis. JOURNAL OF MEDICINAL CHEMISTRY, pp. 1-60, ISSN:0022-2623
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Palli, L.*; Spina, F.; Varese, C.; Romagnolo, A.; Bonari, A.; Bossi, C.; Pompilio, I.; Dugheri, S.; Tilli, S.; Scozzafava, A.; Santianni, D.; Caffaz, S.; Gori, R. (2017). Pharmaceuticals in wastewater treatment plants of tuscany: Occurrence and toxicity. In: G. Mannina (Ed.). Frontiers in Wastewater Treatment and Modelling - Lecture Notes in Civil Engineering, pp. 308-312 Springer, ISBN:978-3-319-58420-1.
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Lucas Canto de Souza, Gustavo Provensi, Daniela Vullo, Fabrizio Carta, Andrea Scozzafava, Alessia Costa, Scheila D. Schmidt; Maria Beatrice Passani, Claudiu T. Supuran, Patrizio Blandina (2017). Carbonic anhydrase activation enhances object recognition memory in mice through phosphorylation of the extracellular signal-regulated kinase in the cortex and the hippocampus.. NEUROPHARMACOLOGY, vol. 118, pp. 148-156, ISSN:1873-7064
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Bua, Silvia; Di Cesare Mannelli, Lorenzo; Vullo, Daniela; Ghelardini, Carla; Bartolucci, Gianluca; Scozzafava, Andrea; Supuran, Claudiu T; Carta, Fabrizio (2017). Design and Synthesis of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Treatment of Rheumatoid Arthritis. JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, pp. 1159-1170, ISSN:0022-2623
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Ferraroni, Marta; Lucarini, Laura; Masini, Emanuela; Korsakov, Mikhail; Scozzafava, Andrea; Supuran, Claudiu T.*; Krasavin, Mikhail (2017). 1,3-Oxazole-based selective picomolar inhibitors of cytosolic human carbonic anhydrase II alleviate ocular hypertension in rabbits: Potency is supported by X-ray crystallography of two leads. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 25, pp. 4560-4565, ISSN:0968-0896
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Ferraroni, Marta; Da Vela, Stefano; Kolvenbach, Boris A.; Corvini, Philippe F.X.; Scozzafava, Andrea (2017). The crystal structures of native hydroquinone 1,2-dioxygenase from Sphingomonas sp. TTNP3 and of substrate and inhibitor complexes. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, vol. 1865, pp. 520-530, ISSN:1570-9639
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Vullo, Daniela; Kumar, R. Siva Sai; Scozzafava, Andrea; Ferry, James G; Supuran, Claudiu T. (2017). Sulphonamide inhibition studies of the β-carbonic anhydrase from the bacterial pathogen Clostridium perfringens. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 33, pp. 31-36, ISSN:1475-6366
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Vullo, Daniela; De Luca, Viviana; Del Prete, Sonia; Carginale, Vincenzo; Scozzafava, Andrea; Osman, Sameh M.; Alothman, Zeid; Capasso, Clemente; Supuran, Claudiu T. (2016). Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic bacterium Colwellia psychrerythraea. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 26, pp. 1253-1259, ISSN:0960-894X
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Vullo, Daniela; Durante, Mariaconcetta; Di Leva, Francesco Saverio; Cosconati, Sandro; Masini, Emanuela; Scozzafava, Andrea; Novellino, Ettore; Supuran, Claudiu T.; Carta, Fabrizio (2016). Monothiocarbamates Strongly Inhibit Carbonic Anhydrases in Vitro and Possess Intraocular Pressure Lowering Activity in an Animal Model of Glaucoma. JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, pp. 5857-5867, ISSN:0022-2623
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Ferraroni, Marta; Carta, Fabrizio; Scozzafava, Andrea; Supuran, Claudiu T. (2016). Thioxocoumarins Show an Alternative Carbonic Anhydrase Inhibition Mechanism Compared to Coumarins. JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, pp. 462-473, ISSN:0022-2623
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Vullo, Daniela; Supuran, Claudiu T.; Scozzafava, Andrea; De Simone, Giuseppina; Monti, Simona Maria; Alterio, Vincenzo; Carta, Fabrizio (2016). Kinetic and X-ray crystallographic investigations of substituted 2-thio-6-oxo-1,6-dihydropyrimidine–benzenesulfonamides acting as carbonic anhydrase inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 24, pp. 3643-3648, ISSN:0968-0896
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Scozzafava, Andrea; Supuran, Claudiu T; Carta, Fabrizio (2016). Polyamines and α-carbonic anhydrases. MOLECULES, vol. 21, pp. 1726-1735, ISSN:1420-3049
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Palli, Laura; Gullotto, Antonella; Tilli, Silvia; Caniani, Donatella; Gori, Riccardo; Scozzafava, Andrea (2016). Biodegradation of 2-naphthalensulfonic acid polymers by white-rot fungi: Scale-up into non-sterile packed bed bioreactors. CHEMOSPHERE, vol. 164, pp. 120-127, ISSN:0045-6535
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Bozdag, Murat; Carta, Fabrizio; Vullo, Daniela*; Isik, Semra; AlOthman, Zeid; Osman, Sameh M.; Scozzafava, Andrea; Supuran, Claudiu T. (2016). Dithiocarbamates with potent inhibitory activity against the Saccharomyces cerevisiae β-carbonic anhydrase. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 31, pp. 132-136, ISSN:1475-6366
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Carta, Fabrizio; Ferraroni, Marta; Scozzafava, Andrea; Supuran, Claudiu T (2016). Fluorescent sulfonamide carbonic anhydrase inhibitors incorporating 1,2,3-triazole moieties: Kinetic and X-ray crystallographic studies. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 24, pp. 104-12-112, ISSN:0968-0896
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Gülçin, İlhami; Scozzafava, Andrea; Supuran, Claudiu T.; Koksal, Zeynep; Turkan, Fikret; Çetinkaya, Songül; Bingöl, Zeynebe; Huyut, Zübeyir; Alwasel, Saleh H. (2016). Rosmarinic acid inhibits some metabolic enzymes including glutathione S-transferase, lactoperoxidase, acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase isoenzymes. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, pp. 1-5, ISSN:1475-6366
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Fulvio Ratto; Ewa Witort; Francesca Tatini; Sonia Centi; Lorenza Lazzeri; Fabrizio Carta; Matteo Lulli; Daniela Vullo; Franco Fusi; Claudiu T. Supuran; Andrea Scozzafava; Sergio Capaccioli; Roberto Pini (2015). Plasmonic Particles that Hit Hypoxic Cells. ADVANCED FUNCTIONAL MATERIALS, vol. 25, pp. 316-323, ISSN:1616-3028
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Gülçin, İlhami; Scozzafava, Andrea; Supuran, Claudiu T; Akıncıoğlu, Hulya; Koksal, Zeynep; Turkan, Fikret; Alwasel, Saleh (2015). The effect of caffeic acid phenethyl ester (CAPE) on metabolic enzymes including acetylcholinesterase, butyrylcholinesterase, glutathione S-transferase, lactoperoxidase, and carbonic anhydrase isoenzymes I, II, IX, and XII. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, pp. 1-7-7, ISSN:1475-6366
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Vullo, Daniela; De Luca, Viviana; Del Prete, Sonia; Carginale, Vincenzo; Scozzafava, Andrea; Capasso, Clemente; Supuran, Claudiu T. (2015). Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 25, pp. 3550-3555, ISSN:0960-894X
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Bragagni, Marco; Scozzafava, Andrea; Mastrolorenzo, Antonio; Supuran, Claudiu T.; Mura, Paola (2015). Development and ex vivo evaluation of 5-aminolevulinic acid-loaded niosomal formulations for topical photodynamic therapy. INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 494, pp. 258-263, ISSN:0378-5173
Vullo, Daniela; De Luca, Viviana; Del Prete, Sonia; Carginale, Vincenzo; Scozzafava, Andrea; Capasso, Clemente; Supuran, Claudiu T. (2015). Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 23, pp. 1728-1734, ISSN:0968-0896
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Bozdag, Murat; Carta, Fabrizio; Vullo, Daniela; Akdemir, Atilla; Isik, Semra; Lanzi, Cecilia; Scozzafava, Andrea; Masini, Emanuela; Supuran, Claudiu T. (2015). Synthesis of a new series of dithiocarbamates with effective human carbonic anhydrase inhibitory activity and antiglaucoma action. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 23, pp. 2368-2376, ISSN:0968-0896
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Tanc, Muhammet; Carta, Fabrizio; Scozzafava, Andrea; Supuran, Claudiu T. (2015). α-carbonic anhydrases possess thioesterase activity. ACS MEDICINAL CHEMISTRY LETTERS, vol. 6, pp. 292-295, ISSN:1948-5875
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Carta, Fabrizio; Di Cesare Mannelli, Lorenzo; Pinard, Melissa; Ghelardini, Carla; Scozzafava, Andrea; Mckenna, Robert; Supuran, Claudiu T. (2015). A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 23, pp. 1828-1840, ISSN:0968-0896
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De Luca, Viviana; Vullo, Daniela; Del Prete, Sonia; Carginale, Vincenzo; Scozzafava, Andrea; Osman, Sameh M.; Alothman, Zeid; Supuran, Claudiu T.; Capasso, Clemente (2015). Cloning, characterization and anion inhibition studies of a new γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 23, pp. 4405-4409, ISSN:0968-0896
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Trabocchi, Andrea; Pala, N.; Krimmelbein, I.; Menchi, Gloria; Guarna, Antonio; Sechi, M.; Dreker, T.; Scozzafava, Andrea; Supuran, CLAUDIU TRANDAFIR; Carta, Fabrizio (2015). Peptidomimetics as protein arginine deiminase 4 (PAD4) inhibitors.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 30, pp. 466-471, ISSN:1475-6366
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M. Tanc;F. Carta;A. Scozzafava;C. T. Supuran (2015). 6-Substituted 1,2-benzoxathiine-2,2-dioxides are isoform-selective inhibitors of human carbonic anhydrases IX, XII and VA.. ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 13, pp. 77-80, ISSN:1477-0520
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Bozdag, Murat; Alafeefy, Ahmed M.; Vullo, Daniela; Carta, Fabrizio; Dedeoglu, Nurcan; Al-Tamimi, Abdul-Malek S.; Al-Jaber, Nabila A.; Scozzafava, Andrea; Supuran, Claudiu T (2015). Benzenesulfonamides incorporating bulky aromatic/heterocyclic tails with potent carbonic anhydrase inhibitory activity. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 23, pp. 7751-7764, ISSN:0968-0896
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Palli, Laura; Gullotto, Antonella; Tilli, Silvia; Scozzafava, Andrea; Caniani, Donatella; Gori, Riccardo (2015). Enzymatic Treatment of Petrochemical Wastewater Containing 2- Naphthalene Sulfonated Polymers by <i>Pleurotus ostreatus</i>. CURRENT BIOTECHNOLOGY, vol. 4, pp. 149-156, ISSN:2211-5501
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A. Scozzafava;P. Kalın;C. T. Supuran;İ. Gülçin;S. H. Alwasel (2015). The impact of hydroquinone on acetylcholine esterase and certain human carbonic anhydrase isoenzymes (hCA I, II, IX, and XII).. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 14, pp. 1-6, ISSN:1475-6366
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Bragagni, Marco; Bozdag, Murat; Carta, Fabrizio; Scozzafava, Andrea; Lanzi, Cecilia; Masini, Emanuela; Mura, Paola; Supuran, Claudiu T. (2015). Cyclodextrin complexation highly enhances efficacy of arylsulfonylureido benzenesulfonamide carbonic anhydrase inhibitors as a topical antiglaucoma agents. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 23, pp. 6223-6227, ISSN:1464-3391
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F. Carta;C. T. Supuran;A. Scozzafava (2014). Sulfonamides and their isosters as carbonic anhydrase inhibitors.. FUTURE MEDICINAL CHEMISTRY, vol. 6, pp. 1149-1165, ISSN:1756-8919
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D. Vullo;E. Flemetakis;A. Scozzafava;C. Capasso;C. T. Supuran (2014). Anion inhibition studies of two α-carbonic anhydrases from Lotus japonicus, LjCAA1 and LjCAA2.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 136, pp. 67-72, ISSN:1475-6366
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S. D. Prete;D. Vullo;A. Scozzafava;C. Capasso;C. T. Supuran (2014). Cloning, characterization and anion inhibition study of the δ-class carbonic anhydrase (TweCA) from the marine diatom Thalassiosira weissflogii.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 22, pp. 531-537, ISSN:0968-0896
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A. Scozzafava;C. T. Supuran (2014). Glaucoma and the applications of carbonic anhydrase inhibitors.. In: Supuran C.. Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications, pp. 349-359 SPRINGER, 233 SPRING ST, NEW YORK, NY 10013 USA.
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D. Vullo;S. D. Prete;S. M. Osman;V. D. Luca;A. Scozzafava;Z. Alothman;C. T. Supuran;C. Capasso (2014). Sulfonamide inhibition studies of the γ-carbonic anhydrase from the oral pathogen Porphyromonas gingivalis.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 24, pp. 240-244, ISSN:0960-894X
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I. Nishimori;D. Vullo;T. Minakuchi;A. Scozzafava;S. M. Osman;Z. Alothman;C. Capasso;C. T. Supuran (2014). Anion inhibition studies of two new β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 24, pp. 1127-1132, ISSN:0960-894X
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D. Vullo;S. D. Prete;S. M. Osman;V. D. Luca;A. Scozzafava;Z. Alothman;C. T. Supuran;C. Capasso (2014). Sulfonamide inhibition studies of the δ-carbonic anhydrase from the diatom Thalassiosira weissflogii.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 24, pp. 275-279, ISSN:0960-894X
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Laura Palli; Antonella Gullotto; Silvia Tilli; Riccardo Gori; Claudio Lubello; Andrea Scozzafava (2014). Biodegradation of naphthalene sulfonate polymers by Pleurotus ostreatus in packed-bed bioreactor. In: IWA specialized conference EcoTechnologies for Wastewater Treatment "ecoSTP2014, Verona, 23-27 Giugno 2014, Roberto Canziani , Francesco Fatone, Evangelia Katsou, pp. 501-504, ISBN:9788869250026
M. Bozdag;M. Ferraroni;E. Nuti;D. Vullo;A. Rossello;F. Carta;A. Scozzafava;C. T. Supuran (2014). Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 22, pp. 334-340, ISSN:0968-0896
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S. D. Prete;D. Vullo;S. M. Osman;A. Scozzafava;Z. AlOthman;C. Capasso;C. T. Supuran (2014). Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: The β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 22, pp. 4537-4543, ISSN:0968-0896
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A. Scozzafava;M. Passaponti;C. T. Supuran;I. Gülçin (2014). Carbonic anhydrase inhibitors: guaiacol and catechol derivatives effectively inhibit certain human carbonic anhydrase isoenzymes (hCA I, II, IX and XII).. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, pp. 1-6, ISSN:1475-6366
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Laura Palli;Antonella Gullotto;Silvia Tilli;Riccardo Gori;Claudio Lubello;Andrea Scozzafava (2014). Effect of carbon source on the degradation of 2-naphthalenesulfonic acid polymers mixture by Pleurotus ostreatus in petrochemical wastewater. PROCESS BIOCHEMISTRY, vol. 49, pp. 2272-2278, ISSN:1359-5113
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D. Vullo;E. V. Kupriyanova;A. Scozzafava;C. Capasso;C. T. Supuran (2014). Anion inhibition study of the β-carbonic anhydrase (CahB1) from the cyanobacterium Coleofasciculus chthonoplastes (ex-Microcoleus chthonoplastes).. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 22, pp. 1667-1671, ISSN:0968-0896
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Carta, Fabrizio*; Scozzafava, Andrea (2014). Next-generation polyamine human carbonic anhydrase inhibitors. In: Claudiu T Supuran e Clemente Capasso. Targeting Carbonic Anhydrases, pp. 68-81 Future medicine, ISBN:978-1-909453-91-3.
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I. Nishimori;D. Vullo;T. Minakuchi;A. Scozzafava;C. Capasso;C. T. Supuran (2014). Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 22, pp. 2939-2946, ISSN:0968-0896
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L. Syrjänen;S. Parkkila;A. Scozzafava;C. T. Supuran (2014). Sulfonamide inhibition studies of the β carbonic anhydrase from Drosophila melanogaster.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 24, pp. 2797-2801, ISSN:0960-894X
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Marina Kolomytseva; Marta Ferraroni; Alexey Chernykh; Ludmila Golovleva; Andrea Scozzafava (2014). Structural basis for the substrate specificity and the absence of dehalogenation activity in 2-chloromuconate cycloisomerase from Rhodococcus opacus 1CP. BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1844, pp. 1541-1549, ISSN:0006-3002
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M. Ferraroni;A. Scozzafava;S. Ullah;T. Tron;A. Piscitelli;G. Sannia (2014). Crystallization and preliminary X-ray crystallographic analysis of the small subunit of the heterodimeric laccase POXA3b from Pleurotus ostreatus.. ACTA CRYSTALLOGRAPHICA. SECTION F, STRUCTURAL BIOLOGY COMMUNICATIONS, vol. 70, pp. 76-79, ISSN:2053-230X
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M. Saada;D. Vullo;J. Montero;A. Scozzafava;C. T. Supuran;J. Winum (2014). Mono- and di-halogenated histamine, histidine and carnosine derivatives are potent carbonic anhydrase I, II, VII, XII and XIV activators.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 22, pp. 4752-4758, ISSN:0968-0896
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D. Vullo;M. Milos;B. Galic;A. Scozzafava;C. T. Supuran (2014). Dipotassium-trioxohydroxytetrafluorotriborate, K2[B3O3F4OH], is a potent inhibitor of human carbonic anhydrases.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, pp. 1-4, ISSN:1475-6366
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D. Vullo;S. D. Prete;S. M. Osman;A. Scozzafava;Z. Alothman;C. T. Supuran;C. Capasso (2014). Anion inhibition study of the β-class carbonic anhydrase (PgiCAb) from the oral pathogen Porphyromonas gingivalis.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 24, pp. 4402-4406, ISSN:0960-894X
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M. Bozdag;M. Ferraroni;F. Carta;D. Vullo;L. Lucarini;E. Orlandini;A. Rossello;E. Nuti;A. Scozzafava;E. Masini;C. T. Supuran (2014). Structural insights on carbonic anhydrase inhibitory action, isoform selectivity, and potency of sulfonamides and coumarins incorporating arylsulfonylureido groups.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 57, pp. 9152-9167, ISSN:0022-2623
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M. Ceruso;S. Antel;D. Vullo;A. Scozzafava;C. T. Supuran (2014). Inhibition studies of new ureido-substituted sulfonamides incorporating a GABA moiety against human carbonic anhydrase isoforms I-XIV.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 22, pp. 6768-6775, ISSN:0968-0896
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E. O. Pettersen;P. Ebbesen;R. G. Gieling;K. J. Williams;L. Dubois;P. Lambin;C. Ward;J. Meehan;I. H. Kunkler;S. P. Langdon;A. H. Ree;K. Flatmark;H. Lyng;M. J. Calzada;L. D. Peso;M. O. Landazuri;A. Görlach;H. Flamm;J. Kieninger;G. Urban;A. Weltin;D. C. Singleton;S. Haider;F. M. Buffa;A. L. Harris;A. Scozzafava;C. T. Supuran;I. Moser;G. Jobst;M. Busk;K. Toustrup;J. Overgaard;J. Alsner;J. Pouyssegur;J. Chiche;N. Mazure;I. Marchiq;S. Parks;A. Ahmed;M. Ashcroft;S. Pastorekova;Y. Cao;K. M. Rouschop;B. G. Wouters;M. Koritzinsky;H. Mujcic;D. Cojocari (2014). Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, pp. 1-33, ISSN:1475-6366
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M. Bozdag;M. Pinard;F. Carta;E. Masini;A. Scozzafava;R. McKenna;C. T. Supuran (2014). A class of 4-Sulfamoylphenyl-ω-aminoalkyl ethers with effective carbonic anhydrase inhibitory action and antiglaucoma effects.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 57, pp. 9673-9686, ISSN:0022-2623
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K. Chegaev;L. Lazzarato;Y. Tamboli;D. Boschi;M. Blangetti;A. Scozzafava;F. Carta;E. Masini;R. Fruttero;C. T. Supuran;A. Gasco (2014). Furazan and furoxan sulfonamides are strong α-carbonic anhydrase inhibitors and potential antiglaucoma agents.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 22, pp. 3913-3921, ISSN:0968-0896
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M. Ceruso;S. D. Prete;Z. AlOthman;S. M. Osman;A. Scozzafava;C. Capasso;C. T. Supuran (2014). Synthesis of sulfonamides with effective inhibitory action against Porphyromonas gingivalis γ-carbonic anhydrase.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 24, pp. 4006-4010, ISSN:0960-894X
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F. Carta;A. Akdemir;A. Scozzafava;E. Masini;C. T. Supuran (2013). Xanthates and Trithiocarbonates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Effects in Vivo.. JOURNAL OF MEDICINAL CHEMISTRY, pp. 4691-4700, ISSN:0022-2623
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E. Masini;F. Carta;A. Scozzafava;C. T. Supuran (2013). Antiglaucoma carbonic anhydrase inhibitors: a patent review.. EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 23, pp. 705-716, ISSN:1354-3776
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M. Ferraroni;M. Kolomytseva;A. Scozzafava;L. Golovleva;F. Briganti (2013). X-ray structures of 4-chlorocatechol 1,2-dioxygenase adducts with substituted catechols: New perspectives in the molecular basis of intradiol ring cleaving dioxygenases specificity.. JOURNAL OF STRUCTURAL BIOLOGY, vol. 181, pp. 274-282, ISSN:1047-8477
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S. D. Prete;V. D. Luca;D. Vullo;A. Scozzafava;V. Carginale;C. T. Supuran;C. Capasso (2013). Biochemical characterization of the γ-carbonic anhydrase from the oral pathogen Porphyromonas gingivalis, PgiCA.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, pp. 532-537, ISSN:1475-6366
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S. Carradori;C. D. Monte;M. D'Ascenzio;D. Secci;G. Celik;M. Ceruso;D. Vullo;A. Scozzafava;C. T. Supuran (2013). Salen and tetrahydrosalen derivatives act as effective inhibitors of the tumor-associated carbonic anhydrase XII--a new scaffold for designing isoform-selective inhibitors.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, pp. 6759-6763, ISSN:0960-894X
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A. Akdemir;O. Güzel-Akdemir;A. Scozzafava;C. Capasso;C. T. Supuran (2013). Inhibition of tumor-associated human carbonic anhydrase isozymes IX and XII by a new class of substituted-phenylacetamido aromatic sulfonamides.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, pp. 5228-5232, ISSN:0968-0896
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M. Tanc;F. Carta;M. Bozdag;A. Scozzafava;C. T. Supuran (2013). 7-Substituted-sulfocoumarins are isoform-selective, potent carbonic anhydrase II inhibitors.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, pp. 4502-4510, ISSN:0968-0896
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I. Nishimori;D. Vullo;T. Minakuchi;A. Scozzafava;C. Capasso;C. T. Supuran (2013). Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, pp. 256-260, ISSN:0960-894X
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CLAUDIU SUPURAN; ANDREA SCOZZAFAVA; EMANUELA MASINI; FABRIZIO CARTA; ERIK OLAI PETTERSEN; PETER EBBERSEN (2013). A CARBONIC ANHYDRASE INHIBITOR COMPRISING A DITHIOCARBAMATE. Numero: WO 2013/050426 A1 CLAUDIU SUPURAN, ANDREA SCOZZAFAVA, EMANUELA MASINI, FABRIZIO CARTA, ERIK OLAI PETTERSEN, PETER EBBERSEN
D. Vullo;R. S. Sai;A. Scozzafava;C. Capasso;J. G. Ferry;C. T. Supuran (2013). Anion inhibition studies of a β-carbonic anhydrase from Clostridium perfringens.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, pp. 6706-6710, ISSN:0960-894X
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M. Ceruso;D. Vullo;A. Scozzafava;C. T. Supuran (2013). Inhibition of human carbonic anhydrase isoforms I-XIV with sulfonamides incorporating fluorine and 1,3,5-triazine moieties.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, pp. 6929-6936, ISSN:0968-0896
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P. Pan;A. B. Vermelho;A. Scozzafava;S. Parkkila;C. Capasso;C. T. Supuran (2013). Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, pp. 4472-4476, ISSN:0968-0896
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D. Vullo;V. D. Luca;A. Scozzafava;V. Carginale;M. Rossi;C. T. Supuran;C. Capasso (2013). The extremo-α-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium azorense is highly inhibited by sulfonamides.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, pp. 4521-4525, ISSN:0968-0896
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H. M. Said;C. Hagemann;F. Carta;A. Katzer;B. Polat;A. Staab;A. Scozzafava;J. Anacker;G. H. Vince;M. Flentje;C. T. Supuran (2013). Hypoxia induced CA9 inhibitory targeting by two different sulfonamide derivatives including acetazolamide in human glioblastoma.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, pp. 3949-3957, ISSN:0968-0896
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C. Alp;A. Maresca;N. A. Alp;M. S. Gültekin;D. Ekinci;A. Scozzafava;C. T. Supuran (2013). Secondary/tertiary benzenesulfonamides with inhibitory action against the cytosolic human carbonic anhydrase isoforms I and II.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. ...., pp. 294-298, ISSN:1475-6366
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A. Maresca;D. Vullo;A. Scozzafava;C. T. Supuran (2013). Inhibition of the alpha- and beta-carbonic anhydrases from the gastric pathogen Helycobacter pylori with anions.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. ....., pp. 388-391, ISSN:1475-6366
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Güzel Akdemir, Ö.; Akdemir, A.; Pan, P.; Vermelho, A. B.; Parkkila, S.; Scozzafava, Andrea; Capasso, C.; Supuran, CLAUDIU TRANDAFIR (2013). A class of sulfonamides with strong inhibitory action against the α-carbonic anhydrase from Trypanosoma cruzi.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, pp. 5773-5781, ISSN:0022-2623
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Bozdag, Murat; Dreker, Tobias; Henry, Christophe; Tosco, Paolo; Vallaro, Maura; Fruttero, Roberta; Scozzafava, Andrea; Carta, Fabrizio*; Supuran, Claudiu T. (2013). Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, pp. 715-719, ISSN:0960-894X
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Biswas, Shyamasri; Carta, Fabrizio; Scozzafava, Andrea; McKenna, Robert*; Supuran, Claudiu T. (2013). Structural effect of phenyl ring compared to thiadiazole based adamantyl-sulfonamides on carbonic anhydrase inhibition. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, pp. 2314-2318, ISSN:0968-0896
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S. D. Prete;D. Vullo;V. D. Luca;V. Carginale;A. Scozzafava;C. T. Supuran;C. Capasso (2013). A highly catalytically active γ-carbonic anhydrase from the pathogenic anaerobe Porphyromonas gingivalis and its inhibition profile with anions and small molecules.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, pp. 4067-4071, ISSN:0960-894X
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Tania Fiaschi;Elisa Giannoni;Maria Letizia Taddei;Paolo Cirri;Alberto Marini;Gianfranco Pintus;Cristina Nativi;Barbara Richichi;Andrea Scozzafava;Fabrizio Carta;Eugenio Torre;Claudiu T. Supuran;Paola Chiarugi (2013). Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells. CELL CYCLE, vol. 12, pp. 1791-1801, ISSN:1538-4101
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F. Carta;D. Vullo;A. Maresca;A. Scozzafava;C. T. Supuran (2013). Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 6, pp. 1564-1569, ISSN:0968-0896
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S. M. Monti;G. D. Simone;N. A. Dathan;M. Ludwig;D. Vullo;A. Scozzafava;C. Capasso;C. T. Supuran (2013). Kinetic and anion inhibition studies of a β-carbonic anhydrase (FbiCA 1) from the C4 plant Flaveria bidentis.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, pp. 1626-1630, ISSN:0960-894X
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A. Akdemir;D. Vullo;V. D. Luca;A. Scozzafava;V. Carginale;M. Rossi;C. T. Supuran;C. Capasso (2013). The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, pp. 1087-1090, ISSN:0960-894X
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M. Ceruso;D. Vullo;A. Scozzafava;C. T. Supuran (2013). Sulfonamides incorporating fluorine and 1,3,5-triazine moieties are effective inhibitors of three β-class carbonic anhydrases from Mycobacterium tuberculosis.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, pp. 686-689, ISSN:1475-6366
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C. T. Supuran;F. Carta;A. Scozzafava (2013). Metalloenzyme inhibitors for the treatment of Gram-negative bacterial infections: a patent review (2009 - 2012).. EXPERT OPINION ON THERAPEUTIC PATENTS, pp. 777-788, ISSN:1354-3776
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M. Ferraroni;I. Matera;S. Bürger;S. Reichert;L. Steimer;A. Scozzafava;A. Stolz;F. Briganti (2013). The salicylate 1,2-dioxygenase as a model for a conventional gentisate 1,2-dioxygenase: crystal structures of the G106A mutant and its adducts with gentisate and salicylate.. THE FEBS JOURNAL, vol. 280, pp. 1643-1652, ISSN:1742-4658
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A. Scozzafava;C. T. Supuran;F. Carta (2013). Antiobesity carbonic anhydrase inhibitors: a literature and patent review.. EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 23, pp. 725-735, ISSN:1354-3776
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P. Pan;A. B. Vermelho;G. C. Rodrigues;A. Scozzafava;M. E. E;S. Parkkila;C. Capasso;C. T. Supuran (2013). Cloning, Characterization, and Sulfonamide and Thiol Inhibition Studies of an α-Carbonic Anhydrase from Trypanosoma cruzi, the Causative Agent of Chagas Disease.. JOURNAL OF MEDICINAL CHEMISTRY, pp. 1761-1771, ISSN:0022-2623
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S. D. Prete;V. D. Luca;A. Scozzafava;V. Carginale;C. T. Supuran;C. Capasso (2013). Biochemical properties of a new α-carbonic anhydrase from the human pathogenic bacterium, Vibrio cholerae.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, pp. 23-27, ISSN:1475-6366
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A. Maresca;D. Vullo;A. Scozzafava;G. Manole;C. T. Supuran (2013). Inhibition of the β-class carbonic anhydrases from Mycobacterium tuberculosis with carboxylic acids.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. ....., pp. 392-396, ISSN:1475-6366
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D. Vullo;V. D. Luca;A. Scozzafava;V. Carginale;M. Rossi;C. T. Supuran;C. Capasso (2013). The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. ...., pp. 1534-1538, ISSN:0968-0896
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D. Vullo;S. Isik;S. D. Prete;V. D. Luca;V. Carginale;A. Scozzafava;C. T. Supuran;C. Capasso (2013). Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, pp. 1636-1638, ISSN:0960-894X
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M. Ferraroni;M. Kolomytseva;L. A. Golovleva;A. Scozzafava (2013). X-ray crystallographic and molecular docking studies on a unique chloromuconolactone dehalogenase from Rhodococcus opacus 1CP.. JOURNAL OF STRUCTURAL BIOLOGY, vol. 182, pp. 44-50, ISSN:1047-8477
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A. M. Marini;A. Maresca;M. Aggarwal;E. Orlandini;S. Nencetti;F. D. Settimo;S. Salerno;F. Simorini;C. L. Motta;S. Taliani;E. Nuti;A. Scozzafava;R. McKenna;A. Rossello;C. T. Supuran (2013). Tryciclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- and β- carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms.. JOURNAL OF MEDICINAL CHEMISTRY, vol. ----, pp. 9619-9629, ISSN:0022-2623
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A. D. Fiore;C. Capasso;V. D. Luca;S. M. Monti;V. Carginale;C. T. Supuran;A. Scozzafava;C. Pedone;M. Rossi;G. D. Simone (2013). X-ray structure of the first `extremo-α-carbonic anhydrase', a dimeric enzyme from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1.. ACTA CRYSTALLOGRAPHICA. SECTION D, BIOLOGICAL CRYSTALLOGRAPHY, vol. 69, pp. 1150-1159, ISSN:0907-4449
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F. Bellissima;F. Carta;A. Innocenti;A. Scozzafava;P. Baglioni;C. T. Supuran;D. Berti (2013). Structural modulation of the biological activity of gold nanoparticles functionalized with a carbonic anhydrase inhibitor.. THE EUROPEAN PHYSICAL JOURNAL. E, SOFT MATTER, vol. 36, pp. 48-57, ISSN:1292-8941
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V. D. Luca;D. Vullo;A. Scozzafava;V. Carginale;M. Rossi;C. T. Supuran;C. Capasso (2013). An α-carbonic anhydrase from the thermophilic bacterium Sulphurihydrogenibium azorense is the fastest enzyme known for the CO(2) hydration reaction.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. ...., pp. 1465-1469, ISSN:0968-0896
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Roberto Pini; Fulvio RATTO; Francesca TATINI; Franco Fusi; Sonia CENTI; Andrea Scozzafava; Claudiu Trandafir SUPURAN; Fabrizio Carta; Sergio Capaccioli; Ewa Janina WITORT (2013). Assembly comprising an absorber of near infrared (nir) light covalently linked to an inhibitor of carbonic anhydrase. Numero: EP2964272 CNR
I. Ciullini;A. Gullotto;S. Tilli;G. Sannia;R. Basosi;A. Scozzafava;F. Briganti (2012). Enzymatic decolorization of spent textile dyeing baths composed by mixtures of synthetic dyes and additives.. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, vol. 96, pp. 395-405, ISSN:1432-0614
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F. Carta;M. Aggarwal;A. Maresca;A. Scozzafava;R. McKenna;C. T. Supuran (2012). Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations.. CHEMICAL COMMUNICATIONS, vol. 48, pp. 1868-1870, ISSN:1359-7345
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K. S. Hewitson;D. Vullo;A. Scozzafava;A. Mastrolorenzo;C. T. Supuran (2012). Molecular Cloning, Characterization, and Inhibition Studies of a β-Carbonic Anhydrase from Malassezia globosa, a Potential Antidandruff Target.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, pp. 3513-3520, ISSN:0022-2623
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V. D. Luca;D. Vullo;A. Scozzafava;V. Carginale;M. Rossi;C. T. Supuran;C. Capasso (2012). Anion inhibition studies of an α-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22, pp. 5630-5634, ISSN:0960-894X
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F. Carta;A. Scozzafava;C. T. Supuran (2012). Sulfonamides: a patent review (2008 - 2012).. EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 22, pp. 747-758, ISSN:1354-3776
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J. Winum;A. Maresca;F. Carta;A. Scozzafava;C. T. Supuran (2012). Polypharmacology of sulfonamides: pazopanib, a multitargeted receptor tyrosine kinase inhibitor in clinical use, potently inhibits several mammalian carbonic anhydrases.. CHEMICAL COMMUNICATIONS, vol. 48, pp. 8177-8179, ISSN:1359-7345
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D. Vullo;V. D. Luca;A. Scozzafava;V. Carginale;M. Rossi;C. T. Supuran;C. Capasso (2012). Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22, pp. 7142-7145, ISSN:0960-894X
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C. T. Supuran;A. Scozzafava (2012). Heterocyclic urea derivatives and methods of use thereof (WO2010142978).. EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 22, pp. 193-197, ISSN:1354-3776
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A. Scozzafava;F. Carta;C. T. Supuran (2012). Secondary and tertiary sulfonamides: a patent review (2008 - 2012).. EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 23, pp. 203-213, ISSN:1354-3776
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M. Ferraroni; L. Steimer; I. Matera; S. Bürger; A. Scozzafava; A. Stolz; F. Briganti (2012). The generation of a 1-hydroxy-2-naphthoate 1,2-dioxygenase by single point mutations of salicylate 1,2-dioxygenase – Rational design of mutants and the crystal structures of the A85H and W104Y variants. JOURNAL OF STRUCTURAL BIOLOGY, vol. 180, pp. 563-571, ISSN:1047-8477
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A. Maresca;A. Scozzafava;S. Köhler;J. Winum;C. T. Supuran (2012). Inhibition of beta-carbonic anhydrases from the bacterial pathogen Brucella suis with inorganic anions.. JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 110, pp. 36-39, ISSN:0162-0134
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S. Durdagi;D. Vullo;P. Pan;N. Kähkönen;J. A. Määttä;V. P. Hytönen;A. Scozzafava;S. Parkkila;C. T. Supuran (2012). Protein-Protein Interactions: Inhibition of Mammalian Carbonic Anhydrases I-XV by the Murine Inhibitor of Carbonic Anhydrase and Other Members of the Transferrin Family.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, pp. 5529-5535, ISSN:0022-2623
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J. Winum;F. Carta;C. Ward;P. Mullen;D. Harrison;S. P. Langdon;A. Cecchi;A. Scozzafava;I. Kunkler;C. T. Supuran (2012). Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22(14), pp. 4681-4685, ISSN:0960-894X
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M. Ferraroni; I. Matera; L. Steimer; S. Bürger; A. Scozzafava; A. Stolz; F. Briganti (2012). Crystal structures of salicylate 1,2-dioxygenase-substrates adducts: A step towards the comprehension of the structural basis for substrate selection in class III ring cleaving dioxygenases. JOURNAL OF STRUCTURAL BIOLOGY, vol. 177, pp. 431-438, ISSN:1047-8477
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G. Balboni;C. Congiu;V. Onnis;A. Maresca;A. Scozzafava;J. Winum;A. Maietti;C. T. Supuran (2012). Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22, pp. 3063-3066, ISSN:0960-894X
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F. Carta;M. Aggarwal;A. Maresca;A. Scozzafava;R. McKenna;E. Masini;C. T. Supuran (2012). Dithiocarbamates strongly inhibit carbonic anhydrases and show antiglaucoma action in vivo.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, pp. 1721-1730, ISSN:0022-2623
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F. Carta;A. Maresca;A. Scozzafava;C. T. Supuran (2012). Novel coumarins and 2-thioxo-coumarins as inhibitors of the tumor-associated carbonic anhydrases IX and XII.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 20, pp. 2266-2273, ISSN:0968-0896
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S. M. Monti;A. Maresca;F. Viparelli;F. Carta;G. D. Simone;F. A. Mühlschlegel;A. Scozzafava;C. T. Supuran (2012). Dithiocarbamates are strong inhibitors of the beta-class fungal carbonic anhydrases from Cryptococcus neoformans, Candida albicans and Candida glabrata.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22, pp. 859-862, ISSN:0960-894X
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F. Carta;C. T. Supuran;A. Scozzafava (2012). Novel therapies for glaucoma: a patent review 2007 - 2011.. EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 22, pp. 79-88, ISSN:1354-3776
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M. Perez-Sayans;A. Garcia-Garcia;A. Scozzafava;C. T. Supuran (2012). Inhibition of V-ATPase and carbonic anhydrases as interference strategy with tumor acidification processes.. CURRENT PHARMACEUTICAL DESIGN, vol. 18, pp. 1407-1413, ISSN:1381-6128
S. Da Vela; M. Ferraroni; B. Kolvenbach; E. Keller; P. Corvini; A. Scozzafava; F. Briganti (2012). Crystallization and preliminary X-ray crystallographic analysis of hydroquinone dioxygenase from Sphingomonas sp. TTNP3. ACTA CRYSTALLOGRAPHICA. SECTION F, STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, vol. F68, pp. 588-590, ISSN:1744-3091
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M. Ferraroni; I. Matera; A. Chernykh; M. Kolomytseva; L. A. Golovleva; A. Scozzafava; F. Briganti (2012). Reaction Intermediates and Redox State Changes in a Blue Laccase from Steccherinum ochraceum observed by Crystallographic High/Low X-Ray Dose Experiments. JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 111, pp. 203-209, ISSN:0162-0134
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R. G. Gieling;M. Babur;L. Mamnani;N. Burrows;B. A. Telfer;F. Carta;J. Winum;A. Scozzafava;C. T. Supuran;K. J. Williams (2012). Antimetastatic Effect of Sulfamate Carbonic Anhydrase IX Inhibitors in Breast Carcinoma Xenografts.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, pp. 5591-5600, ISSN:0022-2623
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F. Carta;D. Vullo;A. Maresca;A. Scozzafava;C. T. Supuran (2012). New chemotypes acting as isozyme-selective carbonic anhydrase inhibitors with low affinity for the offtarget cytosolic isoform II.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22, pp. 2182-2185, ISSN:0960-894X
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S. D. Prete;S. Isik;D. Vullo;V. D. Luca;V. Carginale;A. Scozzafava;C. T. Supuran;C. Capasso (2012). DNA Cloning, Characterization, and Inhibition Studies of an α-Carbonic Anhydrase from the Pathogenic Bacterium Vibrio cholerae.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, pp. 10742-10748, ISSN:0022-2623
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T. Rogez-Florent;S. Meignan;C. Foulon;P. Six;A. Gros;C. Bal-Mahieu;C. T. Supuran;A. Scozzafava;R. Frédérick;B. Masereel;P. Depreux;A. Lansiaux;J. Goossens;S. Gluszok;L. Goossens (2012). New selective carbonic anhydrase IX inhibitors: Synthesis and pharmacological evaluation of diarylpyrazole-benzenesulfonamides.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, pp. 1451-1464, ISSN:0968-0896
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D. Vullo;V. D. Luca;A. Scozzafava;V. Carginale;M. Rossi;C. T. Supuran;C. Capasso (2012). The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22, pp. 6324-6327, ISSN:0960-894X
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S. Parkkila;D. Vullo;A. Maresca;F. Carta;A. Scozzafava;C. T. Supuran (2012). Serendipitous fragment-based drug discovery: ketogenic diet metabolites and statins effectively inhibit several carbonic anhydrases.. CHEMICAL COMMUNICATIONS, vol. 48, pp. 3551-3553, ISSN:1364-548X
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M. Bozdag;T. Dreker;C. Henry;P. Tosco;M. Vallaro;R. Fruttero;A. Scozzafava;F. Carta;C. T. Supuran (2012). Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, pp. 715-719, ISSN:0960-894X
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M. Sechi;A. Innocenti;N. Pala;D. Rogolino;M. Carcelli;A. Scozzafava;C. T. Supuran (2012). Inhibition of α-class cytosolic human carbonic anhydrases I, II, IX and XII, and β-class fungal enzymes by carboxylic acids and their derivatives: new isoform-I selective nanomolar inhibitors.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22, pp. 5801-5806, ISSN:0960-894X
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A. Maresca;A. Scozzafava;D. Vullo;C. T. Supuran (2012). Dihalogenated sulfanilamides and benzolamides are effective inhibitors of the three β-class carbonic anhydrases from Mycobacterium tuberculosis.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, pp. 0-0, ISSN:1475-6366
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K. Tars;D. Vullo;A. Kazaks;J. Leitans;A. Lends;A. Grandane;R. Zalubovskis;A. Scozzafava;C. T. Supuran (2012). Sulfocoumarins (1,2-Benzoxathiine-2,2-dioxides): A Class of Potent and Isoform-Selective Inhibitors of Tumor-Associated Carbonic Anhydrases.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, pp. 293-300, ISSN:0022-2623
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F. Carta;A. Maresca;A. Scozzafava;C. T. Supuran (2012). 5- and 6-membered (thio)lactones are prodrug type carbonic anhydrase inhibitors.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22, pp. 267-270, ISSN:0960-894X
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P. Burghout;D. Vullo;A. Scozzafava;P. W. M Hermans;C. T. Supuran (2011). Inhibition of the β-carbonic anhydrase from Streptococcus pneumoniae by inorganic anions and small molecules: Toward innovative drug design of antiinfectives?. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, pp. 243-248, ISSN:1464-3391
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N. Touisni;A. Maresca;P. C. McDonald;Y. Lou;A. Scozzafava;S. Dedhar;J. Winum;C. T. Supuran (2011). Glycosyl Coumarin Carbonic Anhydrase IX and XII Inhibitors Strongly Attenuate the Growth of Primary Breast Tumors.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, pp. 8271-8277, ISSN:0022-2623
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D. Vullo;I. Nishimori;T. Minakuchi;A. Scozzafava;C. T. Supuran (2011). Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, pp. 3591-3595, ISSN:0960-894X
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S. Biswas;M. Aggarwal;Ö. Güzel;A. Scozzafava;R. McKenna;C. T. Supuran (2011). Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, pp. 3732-3738, ISSN:0968-0896
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M. Saada;D. Vullo;J. Montero;A. Scozzafava;J. Winum;C. T. Supuran (2011). Carbonic anhydrase I and II activation with mono- and dihalogenated histamine derivatives.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, pp. 4884-4887, ISSN:0960-894X
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M. Rami;A. Maresca;F. Smaine;J. Montero;A. Scozzafava;J. Winum;C. T. Supuran (2011). Sulfonamides incorporating boroxazolidone moieties are potent inhibitors of the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, pp. 2975-2979, ISSN:0960-894X
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E. E. Knaus;A. Innocenti;A. Scozzafava;C. T. Supuran (2011). Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, pp. 5892-5896, ISSN:0960-894X
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A. Cincinelli; T. Martellini; A. Innocenti; A. Scozzafava; C.T. Supuran (2011). Purification and inhibition studies with anions and sulfonamides of an a-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19 (6), pp. 1847-1851, ISSN:1464-3391
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F. Carta;V. Garaj;A. Maresca;J. Wagner;B. S. Avvaru;A. H. Robbins;A. Scozzafava;R. McKenna;C. T. Supuran (2011). Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, pp. 3105-3119, ISSN:0968-0896
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Burghout, Peter; Vullo, Daniela; Scozzafava, Andrea; Hermans, Peter W.M.; Supuran, Claudiu T.* (2011). Inhibition of the β-carbonic anhydrase from Streptococcus pneumoniae by inorganic anions and small molecules: Toward innovative drug design of antiinfectives?. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, pp. 243-248, ISSN:0968-0896
DOI
K. Dave;M. A. Ilies;A. Scozzafava;C. Temperini;D. Vullo;C. T. Supuran (2011). An inhibitor-like binding mode of a carbonic anhydrase activator within the active site of isoform II.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, pp. 2764-2768, ISSN:0960-894X
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M. Rami;A. Innocenti;J. Montero;A. Scozzafava;J. Winum;C. T. Supuran (2011). Synthesis of rhodamine B-benzenesulfonamide conjugates and their inhibitory activity against human α- and bacterial/fungal β-carbonic anhydrases.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, pp. 5210-5213, ISSN:0960-894X
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N. Hen;M. Bialer;B. Yagen;A. Maresca;M. Aggarwal;A. H. Robbins;R. McKenna;A. Scozzafava;C. T. Supuran (2011). Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII, and XIV.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, pp. 3977-3981, ISSN:0022-2623
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F. Carta;A. Innocenti;R. A. Hall;F. A. Mühlschlegel;A. Scozzafava;C. T. Supuran (2011). Carbonic anhydrase inhibitors. Inhibition of the β-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with branched aliphatic/aromatic carboxylates and their derivatives.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, pp. 2521-2526, ISSN:0960-894X
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I. Nishimori;T. Minakuchi;D. Vullo;A. Scozzafava;C. T. Supuran (2011). Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, pp. 5023-5030, ISSN:0968-0896
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claudiu supuran, andrea scozzafava, fabrizio carta (2011). CARBONIC ANHYDRASE INHIBITOR COMPRISING A DITHIOCARBAMATE. Numero: WO2013050426 (A1) SUPURAN CLAUDIU T [IT]; SCOZZAFAVA ANDREA [IT]; MASINI EMANUELA [IT]; CARTA FABRIZIO [IT]; PETTERSEN ERIK OLAI [NO]; EBBESEN PETER [DK]
F. Pacchiano; F. Carta; P.C. McDonald; Y. Lou; D.Vullo; A. Scozzafava; S. Dedhar; and C.T. Supuran (2011). Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis. JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, pp. 1896-1902, ISSN:0022-2623
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A. Bertucci;A. Innocenti;A. Scozzafava;S. Tambutté;D. Zoccola;C. T. Supuran (2011). Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 21, pp. 710-714, ISSN:1464-3405
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F. Mincione;F. Benedini;S. Biondi;A. Cecchi;C. Temperini;G. Formicola;I. Pacileo;A. Scozzafava;E. Masini;C. T. Supuran (2011). Synthesis and crystallographic analysis of new sulfonamides incorporating NO-donating moieties with potent antiglaucoma action.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, pp. 3216-3221, ISSN:0960-894X
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Y.Lou; P.C. McDonald; A.Oloumi; S.Chia; C.Ostlund; A. Ahmadi; A.Kyle; U.auf dem Keller; S.Leung; D.Huntsman; B.Clarke; B.W.Sutherland; D.Waterhouse; M.Bally; C.Roskelley; C.M. Overall; A.Minchinton; F.Pacchiano; F. Carta; A.Scozzafava; N.Touisni; J.-Y.Winum; C.T. Supuran; S.Dedhar (2011). Targeting Tumor Hypoxia: Suppression of Breast TumorGrowth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors. CANCER RESEARCH, vol. -----------------, pp. 0-0, ISSN:0008-5472
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P. Joseph;S. Ouahrani-Bettache;J. Montero;I. Nishimori;T. Minakuchi;D. Vullo;A. Scozzafava;J. Winum;S. Köhler;C. T. Supuran (2011). A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, pp. 1172-1178, ISSN:1464-3391
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M. Saada;J. Montero;D. Vullo;A. Scozzafava;J. Winum;C. T. Supuran (2011). Carbonic Anhydrase Activators: Gold Nanoparticles Coated with Derivatized Histamine, Histidine, and Carnosine Show Enhanced Activatory Effects on Several Mammalian Isoforms.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, pp. 1170-1177, ISSN:1520-4804
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K. Dave;A. Scozzafava;D. Vullo;C. T. Supuran;M. A. Ilies (2011). Pyridinium derivatives of histamine are potent activators of cytosolic carbonic anhydrase isoforms I, II and VII.. ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 9, pp. 2790-2800, ISSN:1477-0520
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A. Scozzafava;C. T. Supuran (2011). Heterocyclic compounds and their uses: a patent evaluation of WO2010151735A2.. EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 21, pp. 803-806, ISSN:1354-3776
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L. Dubois;S. Peeters;N. G. Lieuwes;N. Geusens;A. Thiry;S. Wigfield;F. Carta;A. McIntyre;A. Scozzafava;J. Dogné;C. T. Supuran;A. L. Harris;B. Masereel;P. Lambin (2011). Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation.. RADIOTHERAPY AND ONCOLOGY, vol. 99, pp. 424-431, ISSN:0167-8140
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S. Tilli;I. Ciullini;A. Scozzafava;F. Briganti (2011). Differential decolorization of textile dyes in mixtures and the joint effect of laccase and cellobiose dehydrogenase activities present in extracellular extracts from Funalia trogii.. ENZYME AND MICROBIAL TECHNOLOGY, vol. 49, pp. 465-471, ISSN:0141-0229
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F. Pacchiano;F. Carta;D. Vullo;A. Scozzafava;C. T. Supuran (2011). Inhibition of β-carbonic anhydrases with ureido-substituted benzenesulfonamides.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, pp. 102-105, ISSN:0960-894X
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S. Durdagi;M. Sentürk;D. Ekinci;H. T. Balaydın;S. Göksu;O. İ. Küfrevioğlu;A. Innocenti;A. Scozzafava;C. T. Supuran (2011). Kinetic and docking studies of phenol-based inhibitors of carbonic anhydrase isoforms I, II, IX and XII evidence a new binding mode within the enzyme active site.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. --, pp. -----, ISSN:1464-3391
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H. M. Said;C. T. Supuran;C. Hageman;A. Staab;B. Polat;A. Katzer;A. Scozzafava;J. Anacker;M. Flentje;D. Vordermark (2010). Modulation of carbonic anhydrase 9 (CA9) in human brain cancer.. CURRENT PHARMACEUTICAL DESIGN, vol. 16, pp. 3288-3299, ISSN:1381-6128
A. Innocenti;A. Scozzafava;C. T. Supuran (2010). Carbonic anhydrase inhibitors. Inhibition of transmembrane isoforms IX, XII, and XIV with less investigated anions including trithiocarbonate and dithiocarbamate.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 20, pp. 1548-1550, ISSN:1464-3405
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C. Temperini;A. Scozzafava;C. T. Supuran (2010). Carbonic anhydrase inhibitors. X-ray crystal studies of the carbonic anhydrase II-trithiocarbonate adduct--an inhibitor mimicking the sulfonamide and urea binding to the enzyme.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 20, pp. 474-478, ISSN:1464-3405
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I. Nishimori;T. Minakuchi;A. Maresca;F. Carta;A. Scozzafava;C. T. Supuran (2010). The β-carbonic anhydrases from Mycobacterium tuberculosis as drug targets.. CURRENT PHARMACEUTICAL DESIGN, vol. 16, pp. 3300-3309, ISSN:1381-6128
S.Tilli; G.Mori; A.Mannucci; G.Munz; R.Gori; C.Lubello; A.Scozzafava; G.C.Varese; F.Briganti (2010). Natural Tannins For Leather Treatments: Biodegradation By Penicillium Chrysogenum Mut 4444 On A Fixed Bed Bioreactor. In: Feijoo G. and Moreira M.T. Oxidative Enzymes as Sustainable Industrial Catalysts, pp. 270-275, Santiago de Compostela: Feijoo G. and Moreira M.T, ISBN:9788461428243.
F. Viparelli;S. M. Monti;G. D. Simone;A. Innocenti;A. Scozzafava;Y. Xu;F. M. M Morel;C. T. Supuran (2010). Inhibition of the R1 fragment of the cadmium-containing zeta-class carbonic anhydrase from the diatom Thalassiosira weissflogii with anions.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 20, pp. 4745-4748, ISSN:1464-3405
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L. Syrjänen;M. Tolvanen;M. Hilvo;A. Olatubosun;A. Innocenti;A. Scozzafava;J. Leppiniemi;B. Niederhauser;V. P. Hytönen;T. A. Gorr;S. Parkkila;C. T. Supuran (2010). Characterization of the first beta-class carbonic anhydrase from an arthropod (Drosophila melanogaster) and phylogenetic analysis of beta-class carbonic anhydrases in invertebrates.. BMC BIOCHEMISTRY, vol. 11, pp. 28-41, ISSN:1471-2091
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P. Joseph;F. Turtaut;S. Ouahrani-Bettache;J. Montero;I. Nishimori;T. Minakuchi;D. Vullo;A. Scozzafava;S. Köhler;J. Winum;C. T. Supuran (2010). Cloning, characterization, and inhibition studies of a beta-carbonic anhydrase from Brucella suis.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, pp. 2277-2285, ISSN:0022-2623
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D. Vullo;I. Nishimori;A. Scozzafava;S. Köhler;J. Winum;C. T. Supuran (2010). Inhibition studies of a beta-carbonic anhydrase from Brucella suis with a series of water soluble glycosyl sulfanilamides.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 20, pp. 2178-2182, ISSN:0960-894X
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A. Maresca;A. Scozzafava;C. T. Supuran (2010). 7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 20, pp. 7255-7258, ISSN:1464-3405
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A. Maresca;C. Temperini;L. Pochet;B. Masereel;A. Scozzafava;C. T. Supuran (2010). Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, pp. 335-344, ISSN:1520-4804
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C. Temperini;A. Innocenti;A. Scozzafava;S. Parkkila;C. T. Supuran (2010). The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, pp. 850-854, ISSN:1520-4804
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I. Matera; M. Ferraroni; M. Kolomytseva; L. Golovleva; A. Scozzafava; F. Briganti (2010). Catechol 1,2-dioxygenase from the Gram-positive Rhodococcus opacus 1CP: Quantitative structure/activity relationship and the crystal structures of native enzyme and catechols adducts. JOURNAL OF STRUCTURAL BIOLOGY, vol. 170, pp. 548-564, ISSN:1047-8477
A. Innocenti;I. Gülçin;A. Scozzafava;C. T. Supuran (2010). Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 20, pp. 5050-5053, ISSN:1464-3405
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J. Wagner;B. S. Avvaru;A. H. Robbins;A. Scozzafava;C. T. Supuran;R. McKenna (2010). Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 18, pp. 4873-4878, ISSN:1464-3391
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O. Güzel;A. Maresca;R. A. Hall;A. Scozzafava;A. Mastrolorenzo;F. A. Mühlschlegel;C. T. Supuran (2010). Carbonic anhydrase inhibitors. The beta-carbonic anhydrases from the fungal pathogens Cryptococcus neoformans and Candida albicans are strongly inhibited by substituted-phenyl-1H-indole-5-sulfonamides.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 20, pp. 2508-2511, ISSN:1464-3405
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M. P. Kolomytseva; M. Ferraroni ; A.M. Chernykh; A. Scozzafava; F. Briganti; L.A. Golovleva (2010). Experimental and theoretical affinity studies of substituted phenols tochlorocatechol 1,2-dioxygenases: A step toward the comprehension ofinhibitor/substrate binding to intradiol dioxygenases. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, vol. 64, pp. 53-59, ISSN:1381-1177
A. Innocenti;R. A. Hall;A. Scozzafava;F. A. Mühlschlegel;C. T. Supuran (2010). Carbonic anhydrase activators: activation of the beta-carbonic anhydrases from the pathogenic fungi Candida albicans and Cryptococcus neoformans with amines and amino acids.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 18, pp. 1034-1037, ISSN:1464-3391
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A. Innocenti;W. Leewattanapasuk;G. Manole;A. Scozzafava;F. A. Mühlschlegel;C. T. Supuran (2010). Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 20, pp. 1701-1704, ISSN:1464-3405
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F. Carta;C. Temperini;A. Innocenti;A. Scozzafava;K. Kaila;C. T. Supuran (2010). Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, pp. 5511-5522, ISSN:1520-4804
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S. Gluszok;R. Frédérick;C. Foulon;F. Klupsch;C. T. Supuran;D. Vullo;A. Scozzafava;J. Goossens;B. Masereel;P. Depreux;L. Goossens (2010). Design, solid-phase synthesis, and biological evaluation of novel 1,5-diarylpyrrole-3-carboxamides as carbonic anhydrase IX inhibitors.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 18, pp. 7392-7401, ISSN:0968-0896
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F. Pacchiano;M. Aggarwal;B. S. Avvaru;A. H. Robbins;A. Scozzafava;R. McKenna;C. T. Supuran (2010). Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency.. CHEMICAL COMMUNICATIONS, vol. 46, pp. 8371-8373, ISSN:1359-7345
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O. Güzel;A. Innocenti;D. Vullo;A. Scozzafava;C. T. Supuran (2010). 3-phenyl-1H-indole-5-sulfonamides: structure-based drug design of a promising class of carbonic anhydrase inhibitors.. CURRENT PHARMACEUTICAL DESIGN, vol. 16, pp. 3317-3326, ISSN:1381-6128
B. S. Avvaru;J. M. Wagner;A. Maresca;A. Scozzafava;A. H. Robbins;C. T. Supuran;R. McKenna (2010). Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 20, pp. 4376-4381, ISSN:1464-3405
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Nishimori I.; Minakuchi T.; Maresca A.; Carta F.; Scozzafava A.; Supuran C.T. (2010). The β-carbonic anhydrases from Mycobacterium tuberculosis as drug targets. CURRENT PHARMACEUTICAL DESIGN, vol. 16, pp. 3300-3309, ISSN:1381-6128
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L. Crocetti;A. Maresca;C. Temperini;R. A. Hall;A. Scozzafava;F. A. Mühlschlegel;C. T. Supuran (2009). A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 19, pp. 1371-1375, ISSN:1464-3405
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A. Innocenti;S. Pastorekova;J. Pastorek;A. Scozzafava;G. D. Simone;C. T. Supuran (2009). The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 19, pp. 5825-5828, ISSN:1464-3405
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A. Innocenti;M. Hilvo;S. Parkkila;A. Scozzafava;C. T. Supuran (2009). Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 19, pp. 1155-1158, ISSN:1464-3405
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A. Innocenti;R. A. Hall;C. Schlicker;A. Scozzafava;C. Steegborn;F. A. Mühlschlegel;C. T. Supuran (2009). Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 17, pp. 4503-4509, ISSN:1464-3391
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O. Güzel;A. Maresca;A. Scozzafava;A. Salman;A. T. Balaban;C. T. Supuran (2009). Carbonic anhydrase inhibitors. Synthesis of 2,4,6-trimethylpyridinium derivatives of 2-(hydrazinocarbonyl)-3-aryl-1H-indole-5-sulfonamides acting as potent inhibitors of the tumor-associated isoform IX and XII.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 19, pp. 2931-2934, ISSN:1464-3405
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S. Isik;F. Kockar;M. Aydin;O. Arslan;O. O. Guler;A. Innocenti;A. Scozzafava;C. T. Supuran (2009). Carbonic anhydrase activators: activation of the beta-carbonic anhydrase Nce103 from the yeast Saccharomyces cerevisiae with amines and amino acids.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 19, pp. 1662-1665, ISSN:1464-3405
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A. Innocenti;M. Hilvo;S. Parkkila;A. Scozzafava;C. T. Supuran (2009). Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 19, pp. 3430-3433, ISSN:1464-3405
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Marina P Kolomytseva; D. Randazzo; Boris P Baskunov; A. Scozzafava; F. Briganti; Ludmila A Golovleva (2009). Role of surfactants in optimizing fluorene assimilation and intermediate formation by Rhodococcus rhodochrous VKM B-2469.. BIORESOURCE TECHNOLOGY, vol. 100, pp. 839-844, ISSN:0960-8524
O. Güzel;A. Innocenti;A. Scozzafava;A. Salman;C. T. Supuran (2009). Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 17, pp. 4894-4899, ISSN:1464-3391
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J. Winum;A. Innocenti;A. Scozzafava;J. Montero;C. T. Supuran (2009). Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isoforms I and II and transmembrane, tumor-associated isoforms IX and XII with boronic acids.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 17, pp. 3649-3652, ISSN:1464-3391
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A. Bertucci;A. Innocenti;D. Zoccola;A. Scozzafava;S. Tambutté;C. T. Supuran (2009). Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 17, pp. 5054-5058, ISSN:1464-3391
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A. D. Fiore;S. M. Monti;M. Hilvo;S. Parkkila;V. Romano;A. Scaloni;C. Pedone;A. Scozzafava;C. T. Supuran;G. D. Simone (2009). Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide.. PROTEINS, vol. 74, pp. 164-175, ISSN:1097-0134
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A. Innocenti;J. Winum;R. A. Hall;F. A. Mühlschlegel;A. Scozzafava;C. T. Supuran (2009). Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 19, pp. 2642-2645, ISSN:1464-3405
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F. Carta;A. Maresca;A. Scozzafava;D. Vullo;C. T. Supuran (2009). Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XII over the cytosolic isoforms I and II.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 17, pp. 7093-7099, ISSN:0968-0896
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M. Abdo;D. Vullo;M. Saada;J. Montero;A. Scozzafava;J. Winum;C. T. Supuran (2009). Carbonic anhydrase activators: activation of human isozymes I, II and IX with phenylsulfonylhydrazido l-histidine derivatives.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, pp. 2440-2443, ISSN:0960-894X
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I. Nishimori;T. Minakuchi;S. Onishi;D. Vullo;A. Cecchi;A. Scozzafava;C. T. Supuran (2009). Carbonic anhydrase inhibitors. Cloning, characterization and inhibition studies of the cytosolic isozyme III with anions.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 24, pp. 70-76, ISSN:1475-6366
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A. Maresca;F. Carta;D. Vullo;A. Scozzafava;C. T. Supuran (2009). Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamides.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, pp. 4929-4932, ISSN:0960-894X
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I. Nishimori;T. Minakuchi;D. Vullo;A. Scozzafava;A. Innocenti;C. T. Supuran (2009). Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, pp. 3116-3120, ISSN:1520-4804
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T. Minakuchi;I. Nishimori;D. Vullo;A. Scozzafava;C. T. Supuran (2009). Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, pp. 2226-2232, ISSN:1520-4804
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A. Innocenti;A. Scozzafava;C. T. Supuran (2009). Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I, II, III, VII and XIII with less investigated inorganic anions.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 19, pp. 1855-1857, ISSN:1464-3405
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P. Ebbesen;E. O. Pettersen;T. A. Gorr;G. Jobst;K. Williams;J. Kieninger;R. H. Wenger;S. Pastorekova;L. Dubois;P. Lambin;B. G. Wouters;T. V. Den Beucken;C. T. Supuran;L. Poellinger;P. Ratcliffe;A. Kanopka;A. Görlach;M. Gasmann;A. L. Harris;P. Maxwell;A. Scozzafava (2009). Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 24 Suppl 1, pp. 1-39, ISSN:1475-6366
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L. Dubois;N. G. Lieuwes;A. Maresca;A. Thiry;C. T. Supuran;A. Scozzafava;B. G. Wouters;P. Lambin (2009). Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model.. RADIOTHERAPY AND ONCOLOGY, vol. 92, pp. 423-428, ISSN:0167-8140
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S. Singh;P. V. Khadikar;A. Scozzafava;C. T. Supuran (2009). QSAR studies for the inhibition of the transmembrane carbonic anhydrase isozyme XIV with sulfonamides using PRECLAV software.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 24, pp. 337-349, ISSN:1475-6366
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J. Winum;A. Scozzafava;J. Montero;C. T. Supuran (2009). Inhibition of carbonic anhydrase IX: a new strategy against cancer.. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, vol. 9, pp. 693-702, ISSN:1871-5206
A. Maresca;C. Temperini;H. Vu;N. B. Pham;S. Poulsen;A. Scozzafava;R. J. Quinn;C. T. Supuran (2009). Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors.. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 131, pp. 3057-3062, ISSN:0002-7863
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G. D. Simone;A. Scozzafava;C. T. Supuran (2009). Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates?. CHEMICAL BIOLOGY & DRUG DESIGN, vol. 74, pp. 317-321, ISSN:1747-0285
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S. Parkkila;A. Innocenti;H. Kallio;M. Hilvo;A. Scozzafava;C. T. Supuran (2009). The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 19, pp. 4102-4106, ISSN:1464-3405
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O. Güzel;A. Maresca;A. Scozzafava;A. Salman;A. T. Balaban;C. T. Supuran (2009). Discovery of low nanomolar and subnanomolar inhibitors of the mycobacterial beta-carbonic anhydrases Rv1284 and Rv3273.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, pp. 4063-4067, ISSN:1520-4804
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O. Güzel;A. Innocenti;A. Scozzafava;A. Salman;C. T. Supuran (2009). Carbonic anhydrase inhibitors. Phenacetyl-, pyridylacetyl- and thienylacetyl-substituted aromatic sulfonamides act as potent and selective isoform VII inhibitors.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 19, pp. 3170-3173, ISSN:1464-3405
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M. Hilvo;A. M. Salzano;A. Innocenti;M. S. Kulomaa;A. Scozzafava;A. Scaloni;S. Parkkila;C. T. Supuran (2009). Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, pp. 646-654, ISSN:1520-4804
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S. M. I Morsy;A. M. Badawi;A. Cecchi;A. Scozzafava;C. T. Supuran (2009). Carbonic anhydrase inhibitors. Biphenylsulfonamides with inhibitory action towards the transmembrane, tumor-associated isozymes IX possess cytotoxic activity against human colon, lung and breast cancer cell lines.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 24, pp. 499-505, ISSN:1475-6366
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A. Bertucci;A. Innocenti;D. Zoccola;A. Scozzafava;D. Allemand;S. Tambutté;C. T. Supuran (2009). Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 19, pp. 650-653, ISSN:1464-3405
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O. Güzel;A. Innocenti;R. A. Hall;A. Scozzafava;F. A. Mühlschlegel;C. T. Supuran (2009). Carbonic anhydrase inhibitors. The nematode alpha-carbonic anhydrase of Caenorhabditis elegans CAH-4b is highly inhibited by 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 17, pp. 3212-3215, ISSN:1464-3391
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S. Isik;F. Kockar;M. Aydin;O. Arslan;O. O. Guler;A. Innocenti;A. Scozzafava;C. T. Supuran (2009). Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 17, pp. 1158-1163, ISSN:1464-3391
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C. Temperini;A. Cecchi;A. Scozzafava;C. T. Supuran (2009). Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, pp. 322-328, ISSN:1520-4804
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V. Alterio;M. Hilvo;A. D. Fiore;C. T. Supuran;P. Pan;S. Parkkila;A. Scaloni;J. Pastorek;S. Pastorekova;C. Pedone;A. Scozzafava;S. M. Monti;G. D. Simone (2009). Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX.. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 106, pp. 16233-16238, ISSN:1091-6490
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C. Temperini;A. Cecchi;A. Scozzafava;C. T. Supuran (2009). Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 17, pp. 1214-1221, ISSN:1464-3391
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A. Gullotto; S. Branciamore; I. Duchi; M. F. Pareja Cano; D. Randazzo; S. Tilli; P. Giardina; G. Sannia; A. Scozzafava; F. Briganti (2008). Combined action of a bacterial monooxygenase and a fungal laccase for the biodegradation of mono- and poly-aromatic hydrocarbons.. BIORESOURCE TECHNOLOGY, vol. 99, pp. 8353-8359, ISSN:0960-8524
A. Innocenti;A. Scozzafava;S. Parkkila;L. Puccetti;G. D. Simone;C. T. Supuran (2008). Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 18, pp. 2267-2271, ISSN:1464-3405
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R. A. Hall;D. Vullo;A. Innocenti;A. Scozzafava;C. T. Supuran;P. Klappa;F. A. Mühlschlegel (2008). External pH influences the transcriptional profile of the carbonic anhydrase, CAH-4b in Caenorhabditis elegans.. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, vol. 161, pp. 140-149, ISSN:0166-6851
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J. Winum;A. Scozzafava;J. Montero;C. T. Supuran (2008). Design of zinc binding functions for carbonic anhydrase inhibitors.. CURRENT PHARMACEUTICAL DESIGN, vol. 14, pp. 615-621, ISSN:1381-6128
M. Hilvo;L. Baranauskiene;A. M. Salzano;A. Scaloni;D. Matulis;A. Innocenti;A. Scozzafava;S. M. Monti;A. D. Fiore;G. D. Simone;M. Lindfors;J. Jänis;J. Valjakka;S. Pastoreková;J. Pastorek;M. S. Kulomaa;H. R. Nordlund;C. T. Supuran;S. Parkkila (2008). Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes.. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 283, pp. 27799-27809, ISSN:0021-9258
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F. Saczewski;A. Innocenti;J. Sławiński;A. Kornicka;Z. Brzozowski;E. Pomarnacka;A. Scozzafava;C. Temperini;C. T. Supuran (2008). Carbonic anhydrase inhibitors: inhibition of human cytosolic isozymes I and II and tumor-associated isozymes IX and XII with S-substituted 4-chloro-2-mercapto-5-methyl-benzenesulfonamides.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, pp. 3933-3940, ISSN:1464-3391
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A. Innocenti;S. A. Zimmerman;A. Scozzafava;J. G. Ferry;C. T. Supuran (2008). Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 18, pp. 6194-6198, ISSN:1464-3405
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M. Rami;J. Winum;A. Innocenti;J. Montero;A. Scozzafava;C. T. Supuran (2008). Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 18, pp. 836-841, ISSN:1464-3405
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O. Güzel;A. Innocenti;A. Scozzafava;A. Salman;S. Parkkila;M. Hilvo;C. T. Supuran (2008). Carbonic anhydrase inhibitors: synthesis and inhibition studies against mammalian isoforms I-XV with a series of 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, pp. 9113-9120, ISSN:1464-3391
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A. Innocenti;F. A. Mühlschlegel;R. A. Hall;C. Steegborn; A. Scozzafava;C. T. Supuran (2008). Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 18, pp. 5066-5070, ISSN:1464-3405
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D. Vullo;I. Nishimori;A. Scozzafava;C. T. Supuran (2008). Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 18, pp. 4303-4307, ISSN:1464-3405
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Irene Matera; Marta Ferraroni; Sibylle Bürger; Andrea Scozzafava; Andreas Stolz; Fabrizio Briganti (2008). Salicylate 1,2-dioxygenase from Pseudaminobacter salicylatoxidans: crystal structure of a peculiar ring-cleaving dioxygenase.. JOURNAL OF MOLECULAR BIOLOGY, vol. 380, pp. 856-868, ISSN:0022-2836
A. Innocenti;D. Vullo;A. Scozzafava;C. T. Supuran (2008). Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 18, pp. 1583-1587, ISSN:1464-3405
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C. Temperini;A. Cecchi;N. A. Boyle;A. Scozzafava;J. E. Cabeza;P. Wentworth;G. M. Blackburn;C. T. Supuran (2008). Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 18, pp. 999-1005, ISSN:1464-3405
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I. Matera; A. Gullotto; S. Tilli; M. Ferraroni; A. Scozzafava; F. Briganti (2008). Crystal structure of the blue multicopper oxidase from the white-rot fungus Trametes trogii complexed with p-toluate. INORGANICA CHIMICA ACTA, vol. 361, pp. 4129-4137, ISSN:0020-1693
F. Mincione;A. Scozzafava;C. T. Supuran (2008). The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents.. CURRENT PHARMACEUTICAL DESIGN, vol. 14, pp. 649-654, ISSN:1381-6128
S. Morishita;I. Nishimori;T. Minakuchi;S. Onishi;H. Takeuchi;T. Sugiura;D. Vullo;A. Scozzafava;C. T. Supuran (2008). Cloning, polymorphism, and inhibition of beta-carbonic anhydrase of Helicobacter pylori.. JOURNAL OF GASTROENTEROLOGY, vol. 43, pp. 849-857, ISSN:0944-1174
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K. D'Ambrosio;R. Vitale;J. Dogné;B. Masereel;A. Innocenti;A. Scozzafava;G. D. Simone;C. T. Supuran (2008). Carbonic anhydrase inhibitors: bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, pp. 3230-3237, ISSN:0022-2623
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C. Temperini;A. Scozzafava;C. T. Supuran (2008). Carbonic anhydrase activation and the drug design.. CURRENT PHARMACEUTICAL DESIGN, vol. 14, pp. 708-715, ISSN:1381-6128
S. Pastorekova;D. Vullo;I. Nishimori;A. Scozzafava;J. Pastorek;C. T. Supuran (2008). Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, pp. 3530-3536, ISSN:0968-0896
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A. Innocenti;D. Vullo;A. Scozzafava;C. T. Supuran (2008). Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, pp. 7424-7428, ISSN:0968-0896
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A. Thiry;S. Rolin;D. Vullo;A. Frankart;A. Scozzafava;J. Dogné;J. Wouters;C. T. Supuran;B. Masereel (2008). Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, pp. 2853-2860, ISSN:0223-5234
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K. D'Ambrosio;B. Masereel;A. Thiry;A. Scozzafava;C. T. Supuran;G. D. Simone (2008). Carbonic anhydrase inhibitors: binding of indanesulfonamides to the human isoform II.. CHEMMEDCHEM, vol. 3, pp. 473-477, ISSN:1860-7179
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A. Innocenti;A. Maresca;A. Scozzafava;C. T. Supuran (2008). Carbonic anhydrase inhibitors: thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors?. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 18, pp. 3938-3941, ISSN:1464-3405
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A. Innocenti;M. Hilvo;A. Scozzafava;S. Parkkila;C. T. Supuran (2008). Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 18, pp. 3593-3596, ISSN:1464-3405
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C. Temperini;A. Innocenti;A. Scozzafava;C. T. Supuran (2008). Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, pp. 8373-8378, ISSN:1464-3391
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C. Temperini;A. Innocenti;A. Scozzafava;C. T. Supuran (2008). Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 18, pp. 4282-4286, ISSN:1464-3405
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A. Chernykh; N.Myasoedova; M. Kolomytseva; M. Ferraroni; A. Scozzafava; F. Briganti; L. Golovleva (2008). Laccase isoforms with unusual properties from the basidiomycete Steccherinum ochraceum strain 1833. JOURNAL OF APPLIED MICROBIOLOGY, vol. 105, pp. 2065-2075, ISSN:1364-5072
C. Temperini;A. Cecchi;A. Scozzafava;C. T. Supuran (2008). Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 18, pp. 2567-2573, ISSN:1464-3405
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C. Temperini;A. Cecchi;A. Scozzafava;C. T. Supuran (2008). Carbonic anhydrase inhibitors. Sulfonamide diuretics revisited--old leads for new applications?. ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 6, pp. 2499-2506, ISSN:1477-0520
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J. Winum;M. Rami;A. Scozzafava;J. Montero;C. Supuran (2008). Carbonic anhydrase IX: a new druggable target for the design of antitumor agents.. MEDICINAL RESEARCH REVIEWS, vol. 28, pp. 445-463, ISSN:0198-6325
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M. Stiti;A. Cecchi;M. Rami;M. Abdaoui;V. Barragan-Montero;A. Scozzafava;Y. Guari;J. Winum;C. T. Supuran (2008). Carbonic anhydrase inhibitor coated gold nanoparticles selectively inhibit the tumor-associated isoform IX over the cytosolic isozymes I and II.. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 130, pp. 16130-16131, ISSN:0002-7863
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A. Cecchi; L. Ciani; J.Y. Winum; J.L. Montero; A. Scozzafava; S. Ristori; C.T. Supuran (2008). Carbonic anhydrase inhibitors: Design of spin-labeled sulfonamides incorporating TEMPO moieties as probes for cytosolic or transmembrane isozymes. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, pp. 3475-3480, ISSN:0960-894X
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I. Ciullini; S. Tilli; A. Scozzafava; F. Briganti (2008). Fungal laccase, cellobiose dehydrogenase, and chemical mediators: combined actions for the decolorization of different classes of textile dyes.. BIORESOURCE TECHNOLOGY, vol. 99, pp. 7003-7010, ISSN:0960-8524
G. L. Almajan;S. Barbuceanu;A. Innocenti;A. Scozzafava;C. T. Supuran (2008). Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II and IX with some 1,3,4-oxadiazole- and 1,2,4-triazole-thiols.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 23, pp. 101-107, ISSN:1475-6366
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A. Innocenti;M. Hilvo;A. Scozzafava;M. Lindfors;H. R. Nordlund;M. S. Kulomaa;S. Parkkila;C. T. Supuran (2008). Carbonic anhydrase inhibitors: the very weak inhibitors dithiothreitol, beta-mercaptoethanol, tris(carboxyethyl)phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 18, pp. 1898-1903, ISSN:1464-3405
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O. Güzel;C. Temperini;A. Innocenti;A. Scozzafava;A. Salman;C. T. Supuran (2008). Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 18, pp. 152-158, ISSN:1464-3405
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F. Smaine;F. Pacchiano;M. Rami;V. Barragan-Montero;D. Vullo;A. Scozzafava;J. Winum;C. T. Supuran (2008). Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 18, pp. 6332-6335, ISSN:1464-3405
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A. D. Fiore;C. Pedone;J. Antel;H. Waldeck;A. Witte;M. Wurl;A. Scozzafava;C. T. Supuran;G. D. Simone (2008). Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 18, pp. 2669-2674, ISSN:1464-3405
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M. Rami;A. Cecchi;J. Montero;A. Innocenti;D. Vullo;A. Scozzafava;J. Winum;C. T. Supuran (2008). Carbonic anhydrase inhibitors: design of membrane-impermeant copper(II) complexes of DTPA-, DOTA-, and TETA-tailed sulfonamides targeting the tumor-associated transmembrane isoform IX.. CHEMMEDCHEM, vol. 3, pp. 1780-1788, ISSN:1860-7179
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R. M. Vitale;C. Pedone;P. Amodeo;J. Antel;M. Wurl;A. Scozzafava;C. T. Supuran;G. D. Simone (2007). Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 15, pp. 4152-4158, ISSN:0968-0896
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C. T. Supuran;A. Scozzafava (2007). Carbonic anhydrases as targets for medicinal chemistry.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 15, pp. 4336-4350, ISSN:0968-0896
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I. Nishimori;T. Minakuchi;T. Kohsaki;S. Onishi;H. Takeuchi;D. Vullo;A. Scozzafava;C. T. Supuran (2007). Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, pp. 3585-3594, ISSN:0960-894X
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Marta Ferraroni; Nina M Myasoedova; Vadim Schmatchenko; Alexey A Leontievsky; Ludmila A Golovleva; Andrea Scozzafava; Fabrizio Briganti (2007). Crystal structure of a blue laccase from Lentinus tigrinus: evidences for intermediates in the molecular oxygen reductive splitting by multicopper oxidases.. BMC STRUCTURAL BIOLOGY, vol. 7, pp. 60-60, ISSN:1472-6807
D. Vullo;A. Innocenti;I. Nishimori;A. Scozzafava;K. Kaila;C. T. Supuran (2007). Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, pp. 4107-4112, ISSN:0960-894X
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F. Smaine;J. Winum;J. Montero;Z. Regainia;D. Vullo;A. Scozzafava;C. T. Supuran (2007). Carbonic anhydrase inhibitors: Selective inhibition of the extracellular, tumor-associated isoforms IX and XII over isozymes I and II with glycosyl-thioureido-sulfonamides.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, pp. 5096-5100, ISSN:0960-894X
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V. Alterio;G. D. Simone;S. M. Monti;A. Scozzafava;C. T. Supuran (2007). Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, pp. 4201-4207, ISSN:0960-894X
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I. Nishimori;T. Minakuchi;S. Onishi;D. Vullo;A. Cecchi;A. Scozzafava;C. T. Supuran (2007). Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 15, pp. 7229-7236, ISSN:0968-0896
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J. Winum;A. Thiry;K. E. Cheikh;J. Dogné;J. Montero;D. Vullo;A. Scozzafava;B. Masereel;C. T. Supuran (2007). Carbonic anhydrase inhibitors. Inhibition of isoforms I, II, IV, VA, VII, IX, and XIV with sulfonamides incorporating fructopyranose-thioureido tails.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, pp. 2685-2691, ISSN:0960-894X
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C. Temperini;J. Winum;J. Montero;A. Scozzafava;C. T. Supuran (2007). Carbonic anhydrase inhibitors: the X-ray crystal structure of the adduct of N-hydroxysulfamide with isozyme II explains why this new zinc binding function is effective in the design of potent inhibitors.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, pp. 2795-2801, ISSN:0960-894X
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I. Nishimori;T. Minakuchi;S. Onishi;D. Vullo;A. Scozzafava;C. T. Supuran (2007). Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 50, pp. 381-388, ISSN:0022-2623
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A. Casini; G. Mastrobuoni; A. Temperini; C. Gabbiani; S. Francese; G. Moneti; C.T. Supuran; A. Scozzafava; L. Messori (2007). ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme. CHEMICAL COMMUNICATIONS, vol. 2, pp. 156-158, ISSN:1359-7345
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C. Temperini;A. Innocenti;A. Guerri;A. Scozzafava;S. Rusconi;C. T. Supuran (2007). Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, pp. 2210-2215, ISSN:0960-894X
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I. Nishimori;A. Innocenti;D. Vullo;A. Scozzafava;C. T. Supuran (2007). Carbonic anhydrase inhibitors. Inhibition studies of the human secretory isoform VI with anions.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, pp. 1037-1042, ISSN:0960-894X
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C. Temperini;A. Innocenti;A. Scozzafava;A. Mastrolorenzo;C. T. Supuran (2007). Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, pp. 628-635, ISSN:0960-894X
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I. Nishimori;S. Onishi;D. Vullo;A. Innocenti;A. Scozzafava;C. T. Supuran (2007). Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 15, pp. 5351-5357, ISSN:0968-0896
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C. Temperini;A. Innocenti;A. Mastrolorenzo;A. Scozzafava;C. T. Supuran (2007). Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-ray crystallographic studies.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, pp. 4866-4872, ISSN:0960-894X
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L. Dubois;K. Douma;C. T. Supuran;R. K. Chiu;M. A. M J van Zandvoort;S. Pastoreková;A. Scozzafava;B. G. Wouters;P. Lambin (2007). Imaging the hypoxia surrogate marker CA IX requires expression and catalytic activity for binding fluorescent sulfonamide inhibitors.. RADIOTHERAPY AND ONCOLOGY, vol. 83, pp. 367-373, ISSN:0167-8140
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S. Rusconi;A. Scozzafava;A. Mastrolorenzo;C. T. Supuran (2007). An update in the development of HIV entry inhibitors.. CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 7, pp. 1273-1289, ISSN:1568-0266
A. Mastrolorenzo;S. Rusconi;A. Scozzafava;G. Barbaro;C. T. Supuran (2007). Inhibitors of HIV-1 protease: current state of the art 10 years after their introduction. From antiretroviral drugs to antifungal, antibacterial and antitumor agents based on aspartic protease inhibitors.. CURRENT MEDICINAL CHEMISTRY, vol. 14, pp. 2734-2748, ISSN:0929-8673
E. Nuti;E. Orlandini;S. Nencetti;A. Rossello;A. Innocenti;A. Scozzafava;C. T. Supuran (2007). Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with sulfonylated hydroxamates.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 15, pp. 2298-2311, ISSN:0968-0896
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A. Innocenti;D. Vullo;J. Pastorek;A. Scozzafava;S. Pastorekova;I. Nishimori;C. T. Supuran (2007). Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, pp. 1532-1537, ISSN:0960-894X
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P. A. Colinas;R. D. Bravo;D. Vullo;A. Scozzafava;C. T. Supuran (2007). Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I and II, and extracellular isoforms IV, IX, and XII with sulfamides incorporating sugar moieties.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, pp. 5086-5090, ISSN:0960-894X
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A. D. Fiore;A. Scozzafava;J. Winum;J. Montero;C. Pedone;C. T. Supuran;G. D. Simone (2007). Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, pp. 1726-1731, ISSN:0960-894X
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D. Vullo;I. Nishimori;A. Innocenti;A. Scozzafava;C. T. Supuran (2007). Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, pp. 1336-1340, ISSN:0960-894X
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J. Winum;A. Scozzafava;J. Montero;C. T. Supuran (2007). Metal binding functions in the design of carbonic anhydrase inhibitors.. CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 7, pp. 835-848, ISSN:1568-0266
I. Nishimori;A. Innocenti;D. Vullo;A. Scozzafava;C. T. Supuran (2007). Carbonic anhydrase inhibitors: the inhibition profiles of the human mitochondrial isoforms VA and VB with anions are very different.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 15, pp. 6742-6747, ISSN:0968-0896
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M. A. Santos;S. Marques;D. Vullo;A. Innocenti;A. Scozzafava;C. T. Supuran (2007). Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, pp. 1538-1543, ISSN:0960-894X
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J. Winum;A. Cecchi;A. Seridi;A. Scozzafava;J. Montero;C. T. Supuran (2006). Carbonic anhydrase inhibitors. N-cyanomethylsulfonamides--a new zinc binding group in the design of inhibitors targeting cytosolic and membrane-anchored isoforms.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 21, pp. 477-481, ISSN:1475-6366
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J. Winum;A. Scozzafava;J. Montero;C. T. Supuran (2006). Therapeutic potential of sulfamides as enzyme inhibitors.. MEDICINAL RESEARCH REVIEWS, vol. 26, pp. 767-792, ISSN:0198-6325
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S. Parkkila;D. Vullo;L. Puccetti;A. Parkkila;A. Scozzafava;C. T. Supuran (2006). Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, pp. 3955-3959, ISSN:0960-894X
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C. Temperini;A. Scozzafava;D. Vullo;C. T. Supuran (2006). Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: stereospecific recognition within the active site of an enzyme and its consequences for the drug design.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, pp. 3019-3027, ISSN:0022-2623
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C. Temperini;A. Scozzafava;C. T. Supuran (2006). Carbonic anhydrase activators: the first X-ray crystallographic study of an adduct of isoform I.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, pp. 5152-5156, ISSN:0960-894X
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A. Weber;M. Böhm;C. T. Supuran;A. Scozzafava;C. A. Sotriffer;G. Klebe (2006). 3D QSAR selectivity analyses of carbonic anhydrase inhibitors: insights for the design of isozyme selective inhibitors.. JOURNAL OF CHEMICAL INFORMATION AND MODELING, vol. 46, pp. 2737-2760, ISSN:1549-9596
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M. Ferraroni;M. P. Kolomytseva;I. P. Solyanikova;A. Scozzafava;L. A. Golovleva;F. Briganti (2006). Crystal structure of 3-chlorocatechol 1,2-dioxygenase key enzyme of a new modified ortho-pathway from the Gram-positive Rhodococcus opacus 1CP grown on 2-chlorophenol.. JOURNAL OF MOLECULAR BIOLOGY, vol. 360, pp. 788-799, ISSN:0022-2836
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D. Vullo;B. Steffansen;B. Brodin;C. T. Supuran;A. Scozzafava;C. U. Nielsen (2006). Carbonic anhydrase inhibitors: transepithelial transport of thioureido sulfonamide inhibitors of the cancer-associated isozyme IX is dependent on efflux transporters.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 14, pp. 2418-2427, ISSN:0968-0896
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D. Vullo;E. Ruusuvuori;K. Kaila;A. Scozzafava;C. T. Supuran (2006). Carbonic anhydrase inhibitors: inhibition of the cytosolic human isozyme VII with anions.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, pp. 3139-3143, ISSN:0960-894X
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A. D. Fiore;C. Pedone;K. D'Ambrosio;A. Scozzafava;G. D. Simone;C. T. Supuran (2006). Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, pp. 437-442, ISSN:0960-894X
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J. Winum;A. Scozzafava;J. Montero;C. T. Supuran (2006). New zinc binding motifs in the design of selective carbonic anhydrase inhibitors.. MINI-REVIEWS IN MEDICINAL CHEMISTRY, vol. 6, pp. 921-936, ISSN:1389-5575
F. Saczewski;A. Innocenti;Z. Brzozowski;J. Slawiński;E. Pomarnacka;A. Kornicka;A. Scozzafava;C. T. Supuran (2006). Carbonic anhydrase inhibitors. Selective inhibition of human tumor-associated isozymes IX and XII and cytosolic isozymes I and II with some substituted-2-mercapto-benzenesulfonamides.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 21, pp. 563-568, ISSN:1475-6366
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I. Nishimori;D. Vullo;T. Minakuchi;K. Morimoto;S. Onishi;A. Scozzafava;C. T. Supuran (2006). Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, pp. 2182-2188, ISSN:0960-894X
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G. D. Simone;R. M. Vitale;A. D. Fiore;C. Pedone;A. Scozzafava;J. Montero;J. Winum;C. T. Supuran (2006). Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, pp. 5544-5551, ISSN:0022-2623
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M. Zareef;A. Innocenti;R. Iqbal;J. H. Zaidi;M. Arfan;A. Scozzafava;C. T. Supuran (2006). Carbonic anhydrase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozymes I and II with some 1,3,4-oxadiazole-thiols.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 21, pp. 351-359, ISSN:1475-6366
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C. Temperini;A. Innocenti;A. Scozzafava;C. T. Supuran (2006). N-hydroxyurea--a versatile zinc binding function in the design of metalloenzyme inhibitors.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, pp. 4316-4320, ISSN:0960-894X
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J. Winum;C. Temperini;K. E. Cheikh;A. Innocenti;D. Vullo;S. Ciattini;J. Montero;A. Scozzafava;C. T. Supuran (2006). Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, pp. 7024-7031, ISSN:0022-2623
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V. Alterio;R. M. Vitale;S. M. Monti;C. Pedone;A. Scozzafava;A. Cecchi;G. D. Simone;C. T. Supuran (2006). Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX.. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 128, pp. 8329-8335, ISSN:0002-7863
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V. Menchise;G. D. Simone;A. D. Fiore;A. Scozzafava;C. T. Supuran (2006). Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of 5-amino-1,3,4-thiadiazole-2-sulfonamide and 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide to human isoform II.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, pp. 6204-6208, ISSN:0960-894X
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J. Winum;A. Scozzafava;J. Montero;C. T. Supuran (2006). The sulfamide motif in the design of enzyme inhibitors.. EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 16, pp. 27-47, ISSN:1354-3776
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C. T. Supuran;A. Mastrolorenzo;G. Barbaro;A. Scozzafava (2006). Phosphodiesterase 5 inhibitors--drug design and differentiation based on selectivity, pharmacokinetic and efficacy profiles.. CURRENT PHARMACEUTICAL DESIGN, vol. 12, pp. 3459-3465, ISSN:1381-6128
I. Nishimori;T. Minakuchi;K. Morimoto;S. Sano;S. Onishi;H. Takeuchi;D. Vullo;A. Scozzafava;C. T. Supuran (2006). Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, pp. 2117-2126, ISSN:0022-2623
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F. Saczewski;J. Sławiński;A. Kornicka;Z. Brzozowski;E. Pomarnacka;A. Innocenti;A. Scozzafava;C. T. Supuran (2006). Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, pp. 4846-4851, ISSN:0960-894X
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C. Temperini;A. Scozzafava;D. Vullo;C. T. Supuran (2006). Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme.. CHEMISTRY-A EUROPEAN JOURNAL, vol. 12, pp. 7057-7066, ISSN:0947-6539
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O. Ozensoy;S. Isik;O. Arslan;M. Arslan;A. Scozzafava;C. T. Supuran (2005). Carbonic anhydrase inhibitors. Inhibition of red blood cell ostrich (Struthio camelus) carbonic anhydrase with a series of aromatic and heterocyclic sulfonamides.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 20, pp. 383-387, ISSN:1475-6366
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A. D. Fiore;G. D. Simone;V. Menchise;C. Pedone;A. Casini;A. Scozzafava;C. T. Supuran (2005). Carbonic anhydrase inhibitors: X-ray crystal structure of a benzenesulfonamide strong CA II and CA IX inhibitor bearing a pentafluorophenylaminothioureido tail in complex with isozyme II.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, pp. 1937-1942, ISSN:0960-894X
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J. Winum;A. Scozzafava;J. Montero;C. T. Supuran (2005). Sulfamates and their therapeutic potential.. MEDICINAL RESEARCH REVIEWS, vol. 25, pp. 186-228, ISSN:0198-6325
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D. Vullo;A. Innocenti;I. Nishimori;J. Pastorek;A. Scozzafava;S. Pastoreková;C. T. Supuran (2005). Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, pp. 963-969, ISSN:0960-894X
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S. Pastorekova;D. Vullo;A. Casini;A. Scozzafava;J. Pastorek;I. Nishimori;C. T. Supuran (2005). Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isozymes IX and XII with polyfluorinated aromatic/heterocyclic sulfonamides.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 20, pp. 211-217, ISSN:1475-6366
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J. Winum;A. Innocenti;J. Nasr;J. Montero;A. Scozzafava;D. Vullo;C. T. Supuran (2005). Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides--a new zinc-binding function in the design of inhibitors.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, pp. 2353-2358, ISSN:0960-894X
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Z. H. Chohan;C. T. Supuran;A. Scozzafava (2005). Metal binding and antibacterial activity of ciprofloxacin complexes.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 20, pp. 303-307, ISSN:1475-6366
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V. Menchise;G. D. Simone;V. Alterio;A. D. Fiore;C. Pedone;A. Scozzafava;C. T. Supuran (2005). Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, pp. 5721-5727, ISSN:0022-2623
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O. Ozensoy;L. Puccetti;G. Fasolis;O. Arslan;A. Scozzafava;C. T. Supuran (2005). Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, pp. 4862-4866, ISSN:0960-894X
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I. Nishimori;D. Vullo;A. Innocenti;A. Scozzafava;A. Mastrolorenzo;C. T. Supuran (2005). Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, pp. 3828-3833, ISSN:0960-894X
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G. Barbaro;A. Scozzafava;A. Mastrolorenzo;C. T. Supuran (2005). Highly active antiretroviral therapy: current state of the art, new agents and their pharmacological interactions useful for improving therapeutic outcome.. CURRENT PHARMACEUTICAL DESIGN, vol. 11, pp. 1805-1843, ISSN:1381-6128
Rasinger, J. D.; Marrazza, G. ; Briganti, F.; Scozzafava, A. ; Mascini, M.; Turner A. P. F. (2005). Evaluation of an FIA operated amperometric bacterial biosensor, based on pseudomonas putida F1 for the detection of benzene, toluene, ethylbenzene, and xylenes (BTEX). ANALYTICAL LETTERS, vol. 38, pp. 1531-1547, ISSN:0003-2719
A. Cecchi;S. D. Taylor;Y. Liu;B. Hill;D. Vullo;A. Scozzafava;C. T. Supuran (2005). Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, pp. 5192-5196, ISSN:0960-894X
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L. Puccetti;G. Fasolis;D. Vullo;Z. H. Chohan;A. Scozzafava;C. T. Supuran (2005). Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, pp. 3096-3101, ISSN:0960-894X
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G. D. Simone;A. D. Fiore;V. Menchise;C. Pedone;J. Antel;A. Casini;A. Scozzafava;M. Wurl;C. T. Supuran (2005). Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, pp. 2315-2320, ISSN:0960-894X
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M. FERRARONI; J. SEIFERT; V. TRAVKIN; M. THIEL; S. KASCHABEK; A. SCOZZAFAVA; L. GOLOVLEVA; M. SCHLOMANN; F. BRIGANTI (2005). Crystal structure of the hydroxyquinol 1,2-dioxygenase from Nocardioides simplex 3E, a key enzyme involved in polychlorinated aromatics biodegradation. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 280(22), pp. 21144-21154, ISSN:0021-9258, American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824:
V. Garaj;L. Puccetti;G. Fasolis;J. Winum;J. Montero;A. Scozzafava;D. Vullo;A. Innocenti;C. T. Supuran (2005). Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, pp. 3102-3108, ISSN:0960-894X
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I. Nishimori;D. Vullo;A. Innocenti;A. Scozzafava;A. Mastrolorenzo;C. T. Supuran (2005). Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, pp. 7860-7866, ISSN:0022-2623
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L. Puccetti;G. Fasolis;A. Cecchi;J. Winum;A. Gamberi;J. Montero;A. Scozzafava;C. T. Supuran (2005). Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, pp. 2359-2364, ISSN:0960-894X
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J. Winum;A. Cecchi;J. Montero;A. Innocenti;A. Scozzafava;C. T. Supuran (2005). Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with boron-containing sulfonamides, sulfamides, and sulfamates: toward agents for boron neutron capture therapy of hypoxic tumors.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, pp. 3302-3306, ISSN:0960-894X
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M. Ferraroni;I. Duchi;N. M. Myasoedova;A. A. Leontievsky;L. A. Golovleva;A. Scozzafava;F. Briganti (2005). Crystallization and preliminary structure analysis of the blue laccase from the ligninolytic fungus Panus tigrinus.. ACTA CRYSTALLOGRAPHICA. SECTION F, STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, vol. 61, pp. 205-207, ISSN:1744-3091
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C. Temperini;A. Scozzafava;L. Puccetti;C. T. Supuran (2005). Carbonic anhydrase activators: X-ray crystal structure of the adduct of human isozyme II with L-histidine as a platform for the design of stronger activators.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, pp. 5136-5141, ISSN:0960-894X
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O. Ozensoy;I. Nishimori;D. Vullo;L. Puccetti;A. Scozzafava;C. T. Supuran (2005). Carbonic anhydrase inhibitors: inhibition of the human transmembrane isozyme XIV with a library of aromatic/heterocyclic sulfonamides.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 13, pp. 6089-6093, ISSN:0968-0896
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J. Krungkrai;A. Scozzafava;S. Reungprapavut;S. R. Krungkrai;R. Rattanajak;S. Kamchonwongpaisan;C. T. Supuran (2005). Carbonic anhydrase inhibitors. Inhibition of Plasmodium falciparum carbonic anhydrase with aromatic sulfonamides: towards antimalarials with a novel mechanism of action?. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 13, pp. 483-489, ISSN:0968-0896
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H. Turkmen;M. Durgun;S. Yilmaztekin;M. Emul;A. Innocenti;D. Vullo;A. Scozzafava;C. T. Supuran (2005). Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, pp. 367-372, ISSN:0960-894X
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A. Innocenti;M. A. Firnges;J. Antel;M. Wurl;A. Scozzafava;C. T. Supuran (2005). Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, pp. 1149-1154, ISSN:0960-894X
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A. Innocenti;D. Vullo;A. Scozzafava;C. T. Supuran (2005). Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, pp. 567-571, ISSN:0960-894X
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J. Winum;S. Pastorekova;L. Jakubickova;J. Montero;A. Scozzafava;J. Pastorek;D. Vullo;A. Innocenti;C. T. Supuran (2005). Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, pp. 579-584, ISSN:0960-894X
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A. Cecchi;A. Hulikova;J. Pastorek;S. Pastoreková;A. Scozzafava;J. Winum;J. Montero;C. T. Supuran (2005). Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, pp. 4834-4841, ISSN:0022-2623
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D. Vullo;J. Voipio;A. Innocenti;C. Rivera;H. Ranki;A. Scozzafava;K. Kaila;C. T. Supuran (2005). Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, pp. 971-976, ISSN:0960-894X
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F. Mincione;M. Starnotti;E. Masini;L. Bacciottini;C. Scrivanti;A. Casini;D. Vullo;A. Scozzafava;C. T. Supuran (2005). Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, pp. 3821-3827, ISSN:0960-894X
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A. Innocenti;R. Villar;V. Martinez-Merino;M. J. Gil;A. Scozzafava;D. Vullo;C. T. Supuran (2005). Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with benzo[b]thiophene 1,1-dioxide sulfonamides.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, pp. 4872-4876, ISSN:0960-894X
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C. T. Supuran;A. Casini;A. Mastrolorenzo;A. Scozzafava (2004). COX-2 selective inhibitors, carbonic anhydrase inhibition and anticancer properties of sulfonamides belonging to this class of pharmacological agents.. MINI-REVIEWS IN MEDICINAL CHEMISTRY, vol. 4, pp. 625-632, ISSN:1389-5575
C. T. Supuran;A. Scozzafava (2004). Benzolamide is not a membrane-impermeant carbonic anhydrase inhibitor.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 19, pp. 269-273, ISSN:1475-6366
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J. Winum;A. Casini;F. Mincione;M. Starnotti;J. Montero;A. Scozzafava;C. T. Supuran (2004). Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, pp. 225-229, ISSN:0960-894X
J. R. Casey;P. E. Morgan;D. Vullo;A. Scozzafava;A. Mastrolorenzo;C. T. Supuran (2004). Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 47, pp. 2337-2347, ISSN:0022-2623
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M. A. Ilies;B. Masereel;S. Rolin;A. Scozzafava;G. Câmpeanu;V. Cîmpeanu;C. T. Supuran (2004). Carbonic anhydrase inhibitors: aromatic and heterocyclic sulfonamides incorporating adamantyl moieties with strong anticonvulsant activity.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 12, pp. 2717-2726, ISSN:0968-0896
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F. Abbate;A. Casini;T. Owa;A. Scozzafava;C. T. Supuran (2004). Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, pp. 217-223, ISSN:0960-894X
V. Garaj;L. Puccetti;G. Fasolis;J. Winum;J. Montero;A. Scozzafava;D. Vullo;A. Innocenti;C. T. Supuran (2004). Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, pp. 5427-5433, ISSN:0960-894X
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J. M. Lehtonen;S. Parkkila;D. Vullo;A. Casini;A. Scozzafava;C. T. Supuran (2004). Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, pp. 3757-3762, ISSN:0960-894X
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Supuran, C. T.; Scozzafava, A.; Pastorekova, S.; Pastorek, J. (2004). CA IX-specific inhibitors. WO 2004/048544.. Numero: PCT/US2003/037783 C.T. Supuran, A. Scozzafava, S. Pastorekova, J. Pastorek
A. INNOCENTI; A. CASINI; M.C. ALCARO; A.M. PAPINI; A. SCOZZAFAVA; C.T. SUPURAN (2004). Carbonic anhydrase inhibitors: The first on-resin screening of a 4-sulfamoylphenylthioureas library. JOURNAL OF MEDICINAL CHEMISTRY, vol. 47, pp. 5224-5229, ISSN:0022-2623
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Z. H. Chohan;C. T. Supuran;A. Scozzafava (2004). Metalloantibiotics: synthesis and antibacterial activity of cobalt(II), copper(II), nickel(II) and zinc(II) complexes of kefzol.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 19, pp. 79-84, ISSN:1475-6366
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RANDAZZO D.; FERRARONI M.; SCOZZAFAVA A.; GOLOVLEVA L.A.; F. BRIGANTI (2004). Biotransformation of Chloroaromatics: the Impact of Bioavailability and Substrate Specificity.. BIOINORGANIC CHEMISTRY AND APPLICATIONS, vol. 2, pp. 209-223, ISSN:1565-3633
S. Pastorekova;A. Casini;A. Scozzafava;D. Vullo;J. Pastorek;C. T. Supuran (2004). Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, pp. 869-873, ISSN:0960-894X
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F. Abbate;J. Winum;B. V. L;A. Casini;J. Montero;A. Scozzafava;C. T. Supuran (2004). Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, pp. 231-234, ISSN:0960-894X
L. Bonnac;A. Innocenti;J. Winum;A. Casini;J. Montero;A. Scozzafava;V. Barragan;C. T. Supuran (2004). Carbonic anhydrase inhibitors: aliphatic N-phosphorylated sulfamates--a novel zinc-anchoring group leading to nanomolar inhibitors.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 19, pp. 275-278, ISSN:1475-6366
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A. Cecchi;J. Winum;A. Innocenti;D. Vullo;J. Montero;A. Scozzafava;C. T. Supuran (2004). Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, pp. 5775-5780, ISSN:0960-894X
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A. Innocenti;M. A. Firnges;J. Antel;M. Wurl;A. Scozzafava;C. T. Supuran (2004). Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, pp. 5769-5773, ISSN:0960-894X
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S. Rusconi;A. Scozzafava;A. Mastrolorenzo;C. T. Supuran (2004). New advances in HIV entry inhibitors development.. CURRENT DRUG TARGETS. INFECTIOUS DISORDERS, vol. 4, pp. 339-355, ISSN:1568-0053
A. Innocenti;J. Antel;M. Wurl;A. Scozzafava;C. T. Supuran (2004). Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, pp. 5703-5707, ISSN:0960-894X
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DE LEVAL X; ILIES M; CASINI A; DOGNE JM; SCOZZAFAVA A; E. MASINI; MINCIONE F; STARNOTTI M; SUPURAN CT. (2004). Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 20, pp. 2796-2804, ISSN:0022-2623, American Chemical Society:1155 Sixteenth Street Northwest:Washington, DC 20036:(800)227-5558, EMAIL: service@acs.org, INTERNET: http://www.pubs.acs.org, Fax: (614)447-3671:
S. Zimmerman;A. Innocenti;A. Casini;J. G. Ferry;A. Scozzafava;C. T. Supuran (2004). Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, pp. 6001-6006, ISSN:0960-894X
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A. Mastrolorenzo; G. Zuccati; A. Scozzafava; C.T. Supuran (2004). Carbonic anhydrase inhibitors in dermatology. In: C.T. Supuran, A. Scozzafava, J. Conway. Carbonic anhydrase, its inhibitors and activators, pp. 303-315, Boca Raton: CRC Press.
E. Svastová;A. Hulíková;M. Rafajová;M. Zat'ovicová;A. Gibadulinová;A. Casini;A. Cecchi;A. Scozzafava;C. T. Supuran;J. Pastorek;S. Pastoreková (2004). Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH.. FEBS LETTERS, vol. 577, pp. 439-445, ISSN:0014-5793
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A. Weber;A. Casini;A. Heine;D. Kuhn;C. T. Supuran;A. Scozzafava;G. Klebe (2004). Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 47, pp. 550-557, ISSN:0022-2623
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J. Lehtonen;B. Shen;M. Vihinen;A. Casini;A. Scozzafava;C. T. Supuran;A. Parkkila;J. Saarnio;A. J. Kivelä;A. Waheed;W. S. Sly;S. Parkkila (2004). Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family.. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, pp. 2719-2727, ISSN:0021-9258
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M. FERRARONI; I. SOLYANIKOVA; M. KOLOMYTSEVA; A. SCOZZAFAVA; L. GOLOVLEVA; F. BRIGANTI (2004). Crystal structure of 4-chlorocatechol 1,2-dioxygenase from the chlorophenol-utilizing gram-positive Rhodococcus opacus 1CP. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279(26), pp. 27646-27655, ISSN:0021-9258, American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824:
C. T. Supuran;D. Vullo;G. Manole;A. Casini;A. Scozzafava (2004). Designing of novel carbonic anhydrase inhibitors and activators.. CURRENT MEDICINAL CHEMISTRY. CARDIOVASCULAR & HEMATOLOGICAL AGENTS, vol. 2, pp. 49-68, ISSN:1568-0169
C. Chazalette;B. Masereel;S. Rolin;A. Thiry;A. Scozzafava;A. Innocenti;C. T. Supuran (2004). Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, pp. 5781-5786, ISSN:0960-894X
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S. Rusconi;A. Innocenti;D. Vullo;A. Mastrolorenzo;A. Scozzafava;C. T. Supuran (2004). Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, pp. 5763-5767, ISSN:0960-894X
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S. A. Tripodi;M. T. Del;C. T. Supuran;A. Scozzafava;M. G. Gabrielli;S. Pastorekova;R. Rossie;G. Fasolis;L. Puccetti (2004). Redox state and carbonic anhydrase isozyme IX expression in human renal cell carcinoma: biochemical and morphological investigations.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 19, pp. 287-291, ISSN:1475-6366
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A. Innocenti;S. Zimmerman;J. G. Ferry;A. Scozzafava;C. T. Supuran (2004). Carbonic anhydrase inhibitors. Inhibition of the zinc and cobalt gamma-class enzyme from the archaeon Methanosarcina thermophila with anions.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, pp. 3327-3331, ISSN:0960-894X
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M. Ul-Hassan;Z. H. Chohan;A. Scozzafava;C. T. Supuran (2004). Carbonic anhydrase inhibitors: Schiff's bases of aromatic and heterocyclic sulfonamides and their metal complexes.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 19, pp. 263-267, ISSN:1475-6366
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C. T. Supuran;A. Innocenti;A. Mastrolorenzo;A. Scozzafava (2004). Antiviral sulfonamide derivatives.. MINI-REVIEWS IN MEDICINAL CHEMISTRY, vol. 4, pp. 189-200, ISSN:1389-5575
D. Vullo;A. Scozzafava;S. Pastorekova;J. Pastorek;C. T. Supuran (2004). Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, pp. 2351-2356, ISSN:0960-894X
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F. Abbate;A. Coetzee;A. Casini;S. Ciattini;A. Scozzafava;C. T. Supuran (2004). Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, pp. 337-341, ISSN:0960-894X
D. Vullo;M. Franchi;E. Gallori;J. Antel;A. Scozzafava;C. T. Supuran (2004). Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 47, pp. 1272-1279, ISSN:0022-2623
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D. VULLO; M. FRANCHI; E. GALLORI; J. ANTEL; A. SCOZZAFAVA; C. SUPURAN (2004). Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclis sulfonamides.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 47, pp. 1272-1279, ISSN:0022-2623
M. Jaiswal;P. V. Khadikar;A. Scozzafava;C. T. Supuran (2004). Carbonic anhydrase inhibitors: the first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, pp. 3283-3290, ISSN:0960-894X
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M. A. Ilies;D. Vullo;J. Pastorek;A. Scozzafava;M. Ilies;M. T. Caproiu;S. Pastorekova;C. T. Supuran (2003). Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, pp. 2187-2196, ISSN:0022-2623
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A. Casini;J. Antel;F. Abbate;A. Scozzafava;S. David;H. Waldeck;S. Schäfer;C. T. Supuran (2003). Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, pp. 841-845, ISSN:0960-894X
M. FERRARONI; M. Y. RUIZ TARIFA; A. SCOZZAFAVA; I. P. SOLYANIKOVA; M. P. KOLOMYTSEVA; L. GOLOVLEVA; F. BRIGANTI (2003). Preliminary Crystallographic Analysis of 3-Chlorocatechol 1,2-Dioxygenase of a New Modified Ortho-pathway from the Gram-Positive Rhodococcus opacus 1CP Grown on 2-Chlorophenol.. ACTA CRYSTALLOGRAPHICA. SECTION D, BIOLOGICAL CRYSTALLOGRAPHY, vol. 59, pp. 188-190, ISSN:0907-4449
A. SCOZZAFAVA; C. SUPURAN; A. CASINI (2003). CARBONIC ANHYDRASE INHIBITORS. MEDICINAL RESEARCH REVIEWS, vol. 2, pp. 146-189, ISSN:0198-6325
A. Bencini; E. Bill; A. Scozzafava; F. Totti (2003). Density Functional Characterization of the Catalytic Mechanism of [(triphos)Ir(DBTC)]+ with O2: an Insight into Enzymatic Cleavage Occuring in Dioxygenases. CHEMISTRY-A EUROPEAN JOURNAL, vol. 9, pp. 3015-3023, ISSN:0947-6539
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D. Vullo;M. Franchi;E. Gallori;J. Pastorek;A. Scozzafava;S. Pastorekova;C. T. Supuran (2003). Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, pp. 1005-1009, ISSN:0960-894X
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A. Casini;J. Winum;J. Montero;A. Scozzafava;C. T. Supuran (2003). Carbonic anhydrase inhibitors: inhibition of cytosolic isozymes I and II with sulfamide derivatives.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, pp. 837-840, ISSN:0960-894X
J. Winum;D. Vullo;A. Casini;J. Montero;A. Scozzafava;C. T. Supuran (2003). Carbonic anhydrase inhibitors: inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes I and II with aliphatic sulfamates.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, pp. 5471-5477, ISSN:0022-2623
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De Simone G; Menchise V; Omaggio S; Pedone C; Scozzafava A; Supuran CT. (2003). Design of weakly basic thrombin inhibitors incorporating novel P1 binding functions: molecular and X-ray crystallographic studies.. BIOCHEMISTRY, pp. 9013-9021, ISSN:0006-2960
A. Scozzafava;T. Owa;A. Mastrolorenzo;C. T. Supuran (2003). Anticancer and antiviral sulfonamides.. CURRENT MEDICINAL CHEMISTRY, vol. 10, pp. 925-953, ISSN:0929-8673
Z. H. Chohan;A. Scozzafava;C. T. Supuran (2003). Zinc complexes of benzothiazole-derived Schiff bases with antibacterial activity.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 18, pp. 259-263, ISSN:1475-6366
A. Casini;F. Abbate;A. Scozzafava;C. T. Supuran (2003). Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with a bis-sulfonamide-two heads are better than one?. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, pp. 2759-2763, ISSN:0960-894X
J. Winum;D. Vullo;A. Casini;J. Montero;A. Scozzafava;C. T. Supuran (2003). Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, pp. 2197-2204, ISSN:0022-2623
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D. Vullo;M. Franchi;E. Gallori;J. Pastorek;A. Scozzafava;S. Pastorekova;C. T. Supuran (2003). Carbonic anhydrase inhibitors. inhibition of cytosolic isozymes I and II and transmembrane, cancer-associated isozyme IX with anions.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 18, pp. 403-406, ISSN:1475-6366
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F. Abbate;A. Casini;A. Scozzafava;C. T. Supuran (2003). Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the perfluorobenzoyl analogue of methazolamide. Implications for the drug design of fluorinated inhibitors.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 18, pp. 303-308, ISSN:1475-6366
M. A. Santos;S. Marques;M. Gil;M. Tegoni;A. Scozzafava;C. T. Supuran (2003). Protease inhibitors: synthesis of bacterial collagenase and matrix metalloproteinase inhibitors incorporating succinyl hydroxamate and iminodiacetic acid hydroxamate moieties.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 18, pp. 233-242, ISSN:1475-6366
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A. Casini;S. Caccia;A. Scozzafava;C. T. Supuran (2003). Carbonic anhydrase activators. The selective serotonin reuptake inhibitors fluoxetine, sertraline and citalopram are strong activators of isozymes I and II.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, pp. 2765-2768, ISSN:0960-894X
A. Scozzafava;C. T. Supuran (2003). Hydroxyurea is a carbonic anhydrase inhibitor.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11, pp. 2241-2246, ISSN:0968-0896
C. T. Supuran;A. Casini;A. Scozzafava (2003). Protease inhibitors of the sulfonamide type: anticancer, antiinflammatory, and antiviral agents.. MEDICINAL RESEARCH REVIEWS, vol. 23, pp. 535-558, ISSN:0198-6325
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M. Ilies;M. D. Banciu;A. Scozzafava;M. A. Ilies;M. T. Caproiu;C. T. Supuran (2003). Protease inhibitors: synthesis of bacterial collagenase and matrix metalloproteinase inhibitors incorporating arylsulfonylureido and 5-dibenzo-suberenyl/suberyl moieties.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11, pp. 2227-2239, ISSN:0968-0896
A. BENCINI; A. SCOZZAFAVA; F. TOTTI; E. BILL (2003). DENSITY FUNCTIONAL CHARACTERIZATION OF THE CHEMOSELECTIVE OXIDATION OF CATECHOL BY USING MOLECULAR OXYGEN: THERMODYNAMICS OF THE REACTION BETWEEN [(TRIPHOS)IR(DTBC)](+) AND O-2. CHEMISTRY-A EUROPEAN JOURNAL, vol. 9, pp. 3015-3023, ISSN:0947-6539
A. Mastrolorenzo;G. Zuccati;D. Massi;M. G. Gabrielli;A. Casini;A. Scozzafava;C. T. Supuran (2003). Immunohistochemical study of carbonic anhydrase isozymes in human skin.. EUROPEAN JOURNAL OF DERMATOLOGY, vol. 13, pp. 440-444, ISSN:1167-1122, John Libby Eurotext Ltd:127 avenue de la Republique, F 92120 Montrouge France:011 33 1 46730660, EMAIL: marketing@jle.com, INTERNET: http://www.john-libbey-eurotext.fr, Fax: 011 33 1 40840999:
M. FRANCHI; D. VULLO; E. GALLORI; J. ANTEL; M. WURL; A. SCOZZAFAVA; C. SUPURAN (2003). Carbonic anhydrase inhibitors: inhibition of human and murine mitochondrial isozymes V with anions.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, pp. 2857-2861, ISSN:0960-894X, Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010:
A. Casini;A. Scozzafava;F. Mincione;L. Menabuoni;M. Starnotti;C. T. Supuran (2003). Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, pp. 2867-2873, ISSN:0960-894X
M. Franchi;D. Vullo;E. Gallori;J. Pastorek;A. Russo;A. Scozzafava;S. Pastorekova;C. T. Supuran (2003). Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, cancer-associated isozyme IX with lipophilic sulfonamides.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 18, pp. 333-338, ISSN:1475-6366
A. Scozzafava;C. T. Supuran (2002). Carbonic anhydrase inhibitors. Preparation of potent sulfonamides inhibitors incorporating bile acid tails.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 12, pp. 1551-1557, ISSN:0960-894X
M Ferraroni; MY Ruiz Tarifa; F Briganti; A Scozzafava; S Mangani; L Golovleva (2002). The crystal structure of a bacterial intradiol dioxygenases involved in the biodegradation of polychlorinated aromatic compounds.
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Z. H. Chohan;A. Rau;S. Noreen;A. Scozzafava;C. T. Supuran (2002). Antibacterial cobalt(II), nickel(II) and zinc(II) complexes of nicotinic acid-derived Schiff-bases.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 17, pp. 101-106, ISSN:1475-6366
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FERRARONI M.; RUIZ TARIFA M.Y.; BRIGANTI F.; A. SCOZZAFAVA; MANGANI S.; SOLYANIKOVA I.P.; KOLOMYTSEVA M.P.; GOLOVLEVA L. (2002). 4-Chlorocatechol 1,2-dioxygenase fromthe chlorophenol-utilizing Gram-positive Rhodococcus opacus1CP: crystallization and preliminary crystallographic analysis.. ACTA CRYSTALLOGRAPHICA. SECTION D, BIOLOGICAL CRYSTALLOGRAPHY, vol. D58, pp. 1074-76, ISSN:0907-4449, Blackwell Munksgaard:PO Box 2148, Periodicals Department, DK-1016 Copenhagen K Denmark:011 45 33 755913, EMAIL: agentservices@oxon.blackwellpublishing.com, INTERNET: http://www.blackwellmunksgaard.com, Fax: 011 45 77 333377:
C. U. Nielsen;C. T. Supuran;A. Scozzafava;S. Frokjaer;B. Steffansen;B. Brodin (2002). Transport characteristics of L-carnosine and the anticancer derivative 4-toluenesulfonylureido-carnosine in a human epithelial cell line.. PHARMACEUTICAL RESEARCH, vol. 19, pp. 1337-1344, ISSN:0724-8741
Z. H. Chohan;M. A. Farooq;A. Scozzafava;C. T. Supuran (2002). Antibacterial Schiff bases of oxalyl-hydrazine/diamide incorporating pyrrolyl and salicylyl moieties and of their zinc(II) complexes.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 17, pp. 1-7, ISSN:1475-6366
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C. T. Supuran;A. Scozzafava;B. W. Clare (2002). Bacterial protease inhibitors.. MEDICINAL RESEARCH REVIEWS, vol. 22, pp. 329-372, ISSN:0198-6325
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F. Abbate;C. T. Supuran;A. Scozzafava;P. Orioli;M. T. Stubbs;G. Klebe (2002). Nonaromatic sulfonamide group as an ideal anchor for potent human carbonic anhydrase inhibitors: role of hydrogen-bonding networks in ligand binding and drug design.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 45, pp. 3583-3587, ISSN:0022-2623
A. Casini;A. Scozzafava;C. T. Supuran (2002). Cysteine-modifying agents: a possible approach for effective anticancer and antiviral drugs.. ENVIRONMENTAL HEALTH PERSPECTIVES, vol. 110 Suppl 5, pp. 801-806, ISSN:0091-6765
Z. H. Chohan;H. Pervez;A. Rauf;A. Scozzafava;C. T. Supuran (2002). Antibacterial Co(II), Cu(II), Ni(II) and Zn(II) complexes of thiadiazole derived furanyl, thiophenyl and pyrrolyl Schiff bases.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 17, pp. 117-122, ISSN:1475-6366
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A. Scozzafava;C. T. Supuran (2002). Carbonic anhydrase activators: human isozyme II is strongly activated by oligopeptides incorporating the carboxyterminal sequence of the bicarbonate anion exchanger AE1.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 12, pp. 1177-1180, ISSN:0960-894X
Z. H. Chohan;M. S. Iqbal;H. S. Iqbal;A. Scozzafava;C. T. Supuran (2002). Transition metal acetylsalicylates and their anti-inflammatory activity.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 17, pp. 87-91, ISSN:1475-6366
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M.FERRARONI; F.BRIGANTI; W.R.CHEGWIDDEN; C.T.SUPURAN; A.SCOZZAFAVA (2002). Crystal analysis of Aromatic sulfonamide binding to native and (Zn)2adduct to Human Carbonic Anhydrase I Michigan 1. INORGANICA CHIMICA ACTA, vol. 339, pp. 135-144, ISSN:0020-1693
FERRARONI M.; BRIGANTI F.; CHEGWIDDEN W.R.; SUPURAN C.T.; A. SCOZZAFAVA (2002). Crystal analysis of aromatic sulfonamide binding to native and (Zn)2 adduct of human carbonic anhydrase I Michigan 1.. INORGANICA CHIMICA ACTA, vol. 339, pp. 135-144, ISSN:0020-1693, Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598 Editore precedente:Prof Ugo Croatto Luogo pubbl. Padova Ultimo luogo pubblicazione: Lausanne.:
A. SCOZZAFAVA; C. SUPURAN (2002). CARBONIC ANHYDRASE ACTIVATORS: HIGH AFFINITY ISOZYMES I, II AND IV ACTIVATORS INCORPORATING A ALANYL-HISTIDINE SCAFFOLS. JOURNAL OF MEDICINAL CHEMISTRY, vol. 45, pp. 284-291, ISSN:0022-2623
A. Casini;F. Mincione;D. Vullo;L. Menabuoni;A. Scozzafava;C. T. Supuran (2002). Carbonic anhydrase inhibitors with strong topical antiglaucoma properties incorporating a 4-(2-aminopyrimidin-4-yl-amino)-benzenesulfonamide scaffold.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 17, pp. 9-18, ISSN:1475-6366
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B. Masereel;S. Rolin;F. Abbate;A. Scozzafava;C. T. Supuran (2002). Carbonic anhydrase inhibitors: anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 45, pp. 312-320, ISSN:0022-2623
A. Casini;A. Scozzafava;F. Mincione;L. Menabuoni;C. T. Supuran (2002). Carbonic anhydrase inhibitors: synthesis of water soluble sulfonamides incorporating a 4-sulfamoylphenylmethylthiourea scaffold, with potent intraocular pressure lowering properties.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 17, pp. 333-343, ISSN:1475-6366
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A. Scozzafava;A. Mastrolorenzo;C. T. Supuran (2002). Non-peptidic chemokine receptors antagonists as emerging anti-HIV agents.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 17, pp. 69-76, ISSN:1475-6366
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Z. H. Chohan;A. Scozzafava;C. T. Supuran (2002). Unsymmetrical 1,1'-disubstituted ferrocenes: synthesis of Co(ii), Cu(ii), Ni(ii) and Zn(ii) chelates of ferrocenyl -1-thiadiazolo-1'-tetrazole, -1-thiadiazolo-1'-triazole and -1-tetrazolo-1'-triazole with antimicrobial properties.. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 17, pp. 261-266, ISSN:1475-6366
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A. Scozzafava;C. T. Supuran (2002). Carbonic anhydrase activators: high affinity isozymes I, II, and IV activators, incorporating a beta-alanyl-histidine scaffold.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 45, pp. 284-291, ISSN:0022-2623
F. Maestrelli; P. Mura; A. Casini; F. Mincione; A. Scozzafava; C.T. Supuran (2002). Cyclodextrin complexes of sulfonamide carbonic anhydrase inhibitors as long-lasting topically acting antiglaucoma agents. JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 91, pp. 2211-2219, ISSN:0022-3549
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BERTI D.; RANDAZZO D.; F. BRIGANTI; SCOZZAFAVA A.; DI GENNARO P.; GALLI E.; BESTETTI G.; BAGLIONI P. (2002). Nonionic micelles promote whole cell bioconversion of aromatic substrates in an aqueous environment.. LANGMUIR, vol. 18, pp. 6015-6020, ISSN:0743-7463
A. Scozzafava;A. Casini;C. T. Supuran (2002). Targeting cysteine residues of biomolecules: new approaches for the design of antiviral and anticancer drugs.. CURRENT MEDICINAL CHEMISTRY, vol. 9, pp. 1167-1185, ISSN:0929-8673
A. Scozzafava;C. T. Supuran (2002). Protease inhibitors: synthesis of matrix metalloproteinase and bacterial collagenase inhibitors incorporating 5-amino-2-mercapto-1,3,4-thiadiazole zinc binding functions.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 12, pp. 2667-2672, ISSN:0960-894X
A. Scozzafava;L. Menabuoni;F. Mincione;C. T. Supuran (2002). Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 45, pp. 1466-1476, ISSN:0022-2623
M. FERRARONI; S. TILLI; F. BRIGANTI; W. CHEGWIDDEN; C. SUPURAN; K. WIEBAUER; R. TASHIAN; A. SCOZZAFAVA (2002). Crystal structure of a zinc-activated variant of Human Carbonic Anhydrase I, CA I Michigan 1: evidence for a second zinc binding site involving arginine coordination. BIOCHEMISTRY, vol. 41, pp. 6237-6244, ISSN:0006-2960
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A. Scozzafava;A. Mastrolorenzo;C. T. Supuran (2001). Arylsulfonyl-N,N-dialkyl-dithiocarbamates as tumor cell growth inhibitors: novel agents targeting beta-tubulin?. JOURNAL OF ENZYME INHIBITION, vol. 16, pp. 55-63, ISSN:8755-5093
A. Scozzafava;L. Menabuoni;F. Mincione;G. Mincione;C. T. Supuran (2001). Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 11, pp. 575-582, ISSN:0960-894X
A. Scozzafava;A. Mastrolorenzo;C. T. Supuran (2001). Antimycobacterial activity of 3,4-dichlorophenyl-ureas, N,N-diphenyl-ureas and related derivatives.. JOURNAL OF ENZYME INHIBITION, vol. 16, pp. 425-432, ISSN:8755-5093
D. RANDAZZO; D. BERTI; F. BRIGANTI; P. BAGLIONI; A. SCOZZAFAVA; P. DI GENNARO; E. GALLI; G. BESTETTI (2001). Efficient polycyclic aromatic hydrocarbons dihydroxylation in direct micellar systems. BIOTECHNOLOGY AND BIOENGINEERING, vol. 74, pp. 240-248, ISSN:0006-3592, John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551:
C. T. Supuran; F. Briganti; S. Tilli; W. R. Chegwidden; A. Scozzafava (2001). Carbonic anhydrase inhibitors: sulfonamides as antitumor agents?. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 9, pp. 703-714, ISSN:0968-0896
RANDAZZO D; BERTI D; BRIGANTI F; BAGLIONI P; A. SCOZZAFAVA; DI GENNARO P; GALLI E; BESTETTI G (2001). Efficient Polyciclic aromatic hydrocarbons dihydroxylation in direct micellar systems. BIOTECHNOLOGY AND BIOENGINEERING, vol. 74, pp. 240-248, ISSN:0006-3592
Maria Yolanda Ruiz Tarifa; Marta Ferraroni; Fabrizio Briganti; Andrea Scozzafava; Stefano Mangani; Ludmilla Golovleva (2001). Chlorocatechol 1, 2-dioxygenase from the Chlorophenol-utilizing Gram-positive Rhodococcus opacus 1CP: Crystallization and preliminary crystallographic analysis. , in Hasylab Annual reports
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B. W. Clare;A. Scozzafava;C. T. Supuran (2001). Protease inhibitors: synthesis of a series of bacterial collagenase inhibitors of the sulfonyl amino acyl hydroxamate type.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 44, pp. 2253-2258, ISSN:0022-2623
A. Casini;F. Mincione;M. A. Ilies;L. Menabuoni;A. Scozzafava;C. T. Supuran (2001). Carbonic anhydrase inhibitors: synthesis and inhibition against isozymes I, II and IV of topically acting antiglaucoma sulfonamides incorporating cis-5-norbornene-endo-3-carboxy-2-carboxamido moieties.. JOURNAL OF ENZYME INHIBITION, vol. 16, pp. 113-123, ISSN:8755-5093
C. Chazalette;M. Riviere-Baudet;A. Scozzafava;F. Abbate;Z. B. Maarouf;C. T. Supuran (2001). Carbonic anhydrase inhibitors, interaction of boron derivatives with isozymes I and II: a new binding site for hydrophobic inhibitors at the entrance of the active site as shown by docking studies.. JOURNAL OF ENZYME INHIBITION, vol. 16, pp. 125-133, ISSN:8755-5093
A. Scozzafava;I. Saramet;M. D. Banciu;C. T. Supuran (2001). Carbonic anhydrase activity modulators: synthesis of inhibitors and activators incorporating 2-substituted-thiazol-4-yl-methyl scaffolds.. JOURNAL OF ENZYME INHIBITION, vol. 16, pp. 351-358, ISSN:8755-5093
A. Scozzafava;F. Mincione;L. Menabuoni;C. T. Supuran (2001). Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating phthaloyl and phthalimido moieties.. DRUG DESIGN AND DISCOVERY, vol. 17, pp. 337-348, ISSN:1055-9612
B. W. Clare;A. Scozzafava;C. T. Supuran (2001). Protease inhibitors, part 13: Specific, weakly basic thrombin inhibitors incorporating sulfonyl dicyandiamide moieties in their structure.. JOURNAL OF ENZYME INHIBITION, vol. 16, pp. 1-13, ISSN:8755-5093
F. Mincione;M. Starnotti;L. Menabuoni;A. Scozzafava;A. Casini;C. T. Supuran (2001). Carbonic anhydrase inhibitors: 4-sulfamoyl-benzenecarboxamides and 4-chloro-3-sulfamoyl-benzenecarboxamides with strong topical antiglaucoma properties.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 11, pp. 1787-1791, ISSN:0960-894X
C. Chazalette;M. Rivière-Baudet;C. T. Supuran;A. Scozzafava (2001). Carbonic anhydrase inhibitors: allylsulfonamide, styrene sulfonamide, N-allyl sulfonamides and some of their Si, Ge, and B derivatives.. JOURNAL OF ENZYME INHIBITION, vol. 16, pp. 475-489, ISSN:8755-5093
M. Ul-Hassan;A. Scozzafava;Z. H. Chohan;C. T. Supuran (2001). Carbonic anhydrase inhibitors: metal complexes of a sulfanilamide derived Schiff base and their interaction with isozymes I, II and IV.. JOURNAL OF ENZYME INHIBITION, vol. 16, pp. 499-505, ISSN:8755-5093
A. Scozzafava;A. Mastrolorenzo;C. T. Supuran (2001). Antimycobacterial activity of 9-sulfonylated/sulfenylated-6-mercaptopurine derivatives.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 11, pp. 1675-1678, ISSN:0960-894X
A. Mastrolorenzo;A. Scozzafava;C. T. Supuran (2000). The antifungal activity of sulfonylated/carboxylated derivatives of dibenzo-1,4-dioxine-2-acetyloxime may be due to inhibition of lanosterol-14alpha-demethylase.. JOURNAL OF ENZYME INHIBITION, vol. 15, pp. 557-569, ISSN:8755-5093
C. T. Supuran; F. Briganti; G. Mincione; A. Scozzafava (2000). Protease inhibitors: Synthesis of L-alanine hydroxamate sulfonylated derivatives as inhibitors of clostridium histolyticum collagenase.. JOURNAL OF ENZYME INHIBITION, vol. 15, pp. 111-128, ISSN:8755-5093
F. BRIGANTI; PESSIONE E.; GIUNTA C.; MAZZOLI R.; SCOZZAFAVA A. (2000). Purification and catalytic properties of two catechol 1,2-dioxygenase isozymes from benzoate-grown cells of Acinetobacter radioresistens.. JOURNAL OF PROTEIN CHEMISTRY, vol. 19, pp. 709-716, ISSN:0277-8033, Plenum Press:Book Customer Service, 233 Spring Street:New York, NY 10013:(212)620-8471, (212)620-8000, EMAIL: info@plenum.com, INTERNET: http://www.plenum.com, Fax: (212)807-1047:
M. Ilies;C. T. Supuran;A. Scozzafava;A. Casini;F. Mincione;L. Menabuoni;M. T. Caproiu;M. Maganu;M. D. Banciu (2000). Carbonic anhydrase inhibitors: sulfonamides incorporating furan-, thiophene- and pyrrole-carboxamido groups possess strong topical intraocular pressure lowering properties as aqueous suspensions.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 8, pp. 2145-2155, ISSN:0968-0896
A. Scozzafava;C. T. Supuran (2000). Protease inhibitors: synthesis of potent bacterial collagenase and matrix metalloproteinase inhibitors incorporating N-4-nitrobenzylsulfonylglycine hydroxamate moieties.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, pp. 1858-1865, ISSN:0022-2623
I. Fenesan;R. Popescu;A. Scozzafava;V. Crucin;E. Mateiciuc;R. Bauer;M. A. Ilies;C. T. Supuran (2000). Carbonic anhydrase inhibitors; phosphoryl-sulfonamides--a new class of high affinity inhibitors of isozymes I and II.. JOURNAL OF ENZYME INHIBITION, vol. 15, pp. 297-310, ISSN:8755-5093
A. Guerri; F. Briganti; A. Scozzafava; C. T. Supuran; S. Mangani (2000). Mechanism of cyanamide hydration catalyzed by carbonic anhydrase II suggested by cryogenic X-ray diffraction.. BIOCHEMISTRY, vol. 39, pp. 12391-12397, ISSN:0006-2960
C. T. Supuran; F. Briganti; A. Scozzafava; M. A. Ilies (2000). Protease inhibitors: Part 4. Synthesis of weakly basic thrombin inhibitors incorporating pyridinium-sulfanilylaminoguanidine moieties.. JOURNAL OF ENZYME INHIBITION, vol. 15, pp. 335-356, ISSN:8755-5093
B. W. Clare; A. Scozzafava; F. Briganti; B. Iorga; C. T. Supuran (2000). Protease inhibitors. Part 2. Weakly basic thrombin inhibitors incorporating sulfonyl-aminoguanidine moieties as S1 anchoring groups: synthesis and structure-activity correlations.. JOURNAL OF ENZYME INHIBITION, vol. 15, pp. 235-264, ISSN:8755-5093
C. T. Supuran;A. Scozzafava (2000). Activation of carbonic anhydrase isozymes.. EXS, pp. 197-219, ISSN:1023-294X
M. Barboiu; C. T. Supuran; L. Menabuoni; A. Scozzafava; F. Mincione; F. Briganti; G. Mincione (2000). Carbonic anhydrase inhibitors. Synthesis of topically effective intraocular pressure lowering agents derived from 5-(omega-aminoalkylcarboxamido)-1,3,4-thiadiazole-2-sulfonamide.. JOURNAL OF ENZYME INHIBITION, vol. 15, pp. 23-46, ISSN:8755-5093
BERTI D.; RANDAZZO D.; BRIGANTI F.; P. BAGLIONI; SCOZZAFAVA A.; DI GENNARO P.; GALLI E.; BESTETTI G. (2000). Direct Micellar Systems as a Tool to Improve the Efficiency of Aromatic Substrate Conversion for Fine Chemicals Production. JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 79(1-4), pp. 103-108, ISSN:0162-0134
C. T. Supuran; F. Briganti; L. Menabuoni; G. Mincione; F. Mincione; A. Scozzafava (2000). Carbonic anhydrase inhibitors - part 78(#). Synthesis of water-soluble sulfonamides incorporating beta-alanyl moieties, possessing long lasting-intraocular pressure lowering properties via the topical route.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 35, pp. 309-321, ISSN:0223-5234
A. Scozzafava;C. T. Supuran (2000). Carbonic anhydrase activators. Part 24. High affinity isozymes I, II and IV activators, derivatives of 4-(4-chlorophenylsulfonylureido-amino acyl)ethyl-1H-imidazole.. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 10, pp. 29-41, ISSN:0928-0987
A. Mastrolorenzo;A. Scozzafava;C. T. Supuran (2000). Antifungal activity of silver and zinc complexes of sulfadrug derivatives incorporating arylsulfonylureido moieties.. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 11, pp. 99-107, ISSN:0928-0987
A. Scozzafava;C. T. Supuran (2000). Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, pp. 3677-3687, ISSN:0022-2623
G. Renzi;A. Scozzafava;C. T. Supuran (2000). Carbonic anhydrase inhibitors: topical sulfonamide antiglaucoma agents incorporating secondary amine moieties.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 10, pp. 673-676, ISSN:0960-894X
A. Scozzafava;C. T. Supuran (2000). Protease inhibitors - part 5. Alkyl/arylsulfonyl- and arylsulfonylureido-/arylureido- glycine hydroxamate inhibitors of Clostridium histolyticum collagenase.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 35, pp. 299-307, ISSN:0223-5234
A. Mastrolorenzo;A. Scozzafava;C. T. Supuran (2000). 4-toluenesulfonylureido derivatives of amines, amino acids and dipeptides: a novel class of potential antitumor agents.. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 11, pp. 325-332, ISSN:0928-0987
A. Bencini; E. Bill; F. Mariotti; F. Totti; A. Scozzafava; A. Vargas (2000). Density Functional Description of the Early Stages in the Dioxygenation of [(triphos)M(Catecholate)]+ Complexes [M = Co(III), Ir(III)]. Toward a rationalization of the catalytic mechanism of ring opening dioxygenases. INORGANIC CHEMISTRY, vol. 39, pp. 1418-1425, ISSN:0020-1669
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C. T. Supuran; A. Scozzafava; M. A. Ilies; F. Briganti (2000). Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating 2,4,6-trisubstituted-pyridinium-ethylcarboxamido moieties possessing membrane-impermeability and in vivo selectivity for the membrane-bound (CA IV) versus the cytosolic (CA I and CA II) isozymes.. JOURNAL OF ENZYME INHIBITION, vol. 15, pp. 381-401, ISSN:8755-5093
A. Scozzafava; F. Briganti; M. A. Ilies; C. T. Supuran (2000). Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, pp. 292-300, ISSN:0022-2623
A. Scozzafava;A. Mastrolorenzo;C. T. Supuran (2000). Arylsulfonyl-N,N-diethyl-dithiocarbamates: a novel class of antitumor agents.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 10, pp. 1887-1891, ISSN:0960-894X
A. Casini;A. Scozzafava;F. Mincione;L. Menabuoni;M. A. Ilies;C. T. Supuran (2000). Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, pp. 4884-4892, ISSN:0022-2623
A. Scozzafava;B. Iorga;C. T. Supuran (2000). Carbonic anhydrase activators: synthesis of high affinity isozymes I, II and IV activators, derivatives of 4-(4-tosylureido-amino acyl)ethyl-1H-imidazole (histamine derivatives).. JOURNAL OF ENZYME INHIBITION, vol. 15, pp. 139-161, ISSN:8755-5093
A. Scozzafava;M. A. Ilies;G. Manole;C. T. Supuran (2000). Protease inhibitors. Part 12. Synthesis of potent matrix metalloproteinase and bacterial collagenase inhibitors incorporating sulfonylated N-4-nitrobenzyl-beta-alanine hydroxamate moieties.. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 11, pp. 69-79, ISSN:0928-0987
A. Scozzafava;C. T. Supuran (2000). Carbonic anhydrase inhibitors: synthesis of N-morpholylthiocarbonylsulfenylamino aromatic/heterocyclic sulfonamides and their interaction with isozymes I, II and IV.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 10, pp. 1117-1120, ISSN:0960-894X
A. Scozzafava;C. T. Supuran (2000). Protease inhibitors: synthesis of clostridium histolyticum collagenase inhibitors incorporating sulfonyl-L-alanine hydroxamate moieties.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 10, pp. 499-502, ISSN:0960-894X
A. Scozzafava;C. T. Supuran (2000). Carbonic anhydrase activators - part 21. Novel activators of isozymes I, II and IV incorporating carboxamido and ureido histamine moieties.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 35, pp. 31-39, ISSN:0223-5234
M. A. Ilies;C. T. Supuran;A. Scozzafava (2000). Carbonic anhydrase inhibitors. Part 91. Metal complexes of heterocyclic sulfonamides as potential pharmacological agents in the treatment of gastric Acid secretion imbalances.. METAL-BASED DRUGS, vol. 7, pp. 57-62, ISSN:0793-0291
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A. Scozzafava;M. D. Banciu;A. Popescu;C. T. Supuran (2000). Carbonic anhydrase inhibitors: inhibition of isozymes I, II and IV by sulfamide and sulfamic acid derivatives.. JOURNAL OF ENZYME INHIBITION, vol. 15, pp. 443-453, ISSN:8755-5093
C. T. Supuran;A. Scozzafava (2000). Carbonic anhydrase activators: synthesis of high affinity isozymes I, II and IV activators, derivatives of 4-(arylsulfonylureido-amino acyl)ethyl-1H-imidazole.. JOURNAL OF ENZYME INHIBITION, vol. 15, pp. 471-486, ISSN:8755-5093
A. Mastrolorenzo;A. Scozzafava;C. T. Supuran (2000). Antifungal activity of Ag(I) and Zn(II) complexes of aminobenzolamide (5-sulfanilylamido-1,3,4-thiadiazole-2-sulfonamide) derivatives.. JOURNAL OF ENZYME INHIBITION, vol. 15, pp. 517-531, ISSN:8755-5093
A. Scozzafava;M. D. Banciu;A. Popescu;C. T. Supuran (2000). Carbonic anhydrase inhibitors: synthesis of Schiff bases of hydroxybenzaldehydes with aromatic sulfonamides and their reactions with arylsulfonyl isocyanates.. JOURNAL OF ENZYME INHIBITION, vol. 15, pp. 533-546, ISSN:8755-5093
C. T. Supuran;A. Scozzafava (2000). Carbonic anhydrase inhibitors: aromatic sulfonamides and disulfonamides act as efficient tumor growth inhibitors.. JOURNAL OF ENZYME INHIBITION, vol. 15, pp. 597-610, ISSN:8755-5093
C. T. Supuran;A. Scozzafava (2000). Carbonic anhydrase inhibitors--Part 94. 1,3,4-thiadiazole-2-sulfonamidederivatives as antitumor agents?. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 35, pp. 867-874, ISSN:0223-5234
A. Scozzafava; L. Menabuoni; F. Mincione; F. Briganti; G. Mincione; C. T. Supuran (2000). Carbonic anhydrase inhibitors: perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, pp. 4542-4551, ISSN:0022-2623
C. T. Supuran; A. Scozzafava; F. Briganti; B. W. Clare (2000). Protease inhibitors: synthesis and QSAR study of novel classes of nonbasic thrombin inhibitors incorporating sulfonylguanidine and O-methylsulfonylisourea moieties at P1.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, pp. 1793-1806, ISSN:0022-2623
C. T. Supuran;A. Scozzafava (2000). Protease inhibitors. Part 7. Inhibition of Clostridium histolyticum collagenase with sulfonylated derivatives of L-valine hydroxamate.. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 10, pp. 67-76, ISSN:0928-0987
C. T. Supuran;A. Scozzafava (1999). Carbonic anhydrase activators: amino acyl/dipeptidyl histamine derivatives bind with high affinity to isozymes I, II and IV and act as efficient activators.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 7, pp. 2915-2923, ISSN:0968-0896
C. T. Supuran; A. Scozzafava; L. Menabuoni; F. Mincione; F. Briganti; G. Mincione (1999). Carbonic Anhydrase Inhibitors Part 72 Synthesis and Antiglaucoma Properties of Metal Complexes of p-Fluorobenzolamide.. METAL-BASED DRUGS, vol. 6, pp. 67-73, ISSN:0793-0291
F. BRIGANTI;D. RANDAZZO;A. SCOZZAFAVA; D. BERTI;P. BAGLIONI; P. DI GENNARO;E. GALLI;G. BESTETTI (1999). Characterization of the biological conversion of naphthalene to (+)-cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene in direct micellar systems. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, vol. 7, pp. 263-272, ISSN:1381-1177, Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598:
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F. Briganti; S. Mangani; A. Scozzafava; G. Vernaglione; C. T. Supuran (1999). Carbonic anhydrase catalyzes cyanamide hydration to urea: is it mimicking the physiological reaction?. JBIC, vol. 4, pp. 528-536, ISSN:0949-8257
J. Borras; A. Scozzafava; L. Menabuoni; F. Mincione; F. Briganti; G. Mincione; C. T. Supuran (1999). Carbonic anhydrase inhibitors: synthesis of water-soluble, topically effective intraocular pressure lowering aromatic/heterocyclic sulfonamides containing 8-quinoline-sulfonyl moieties: is the tail more important than the ring?. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 7, pp. 2397-2406, ISSN:0968-0896
A. Popescu; A. Simion; A. Scozzafava; F. Briganti; C. T. Supuran (1999). Carbonic anhydrase inhibitors. Schiff bases of some aromatic sulfonamides and their metal complexes: towards more selective inhibitors of carbonic anhydrase isozyme IV.. JOURNAL OF ENZYME INHIBITION, vol. 14, pp. 407-423, ISSN:8755-5093
G. Mincione; L. Menabuoni; F. Briganti; F. Mincione; A. Scozzafava; C. T. Supuran (1999). Carbonic anhydrase inhibitors. Part 79. Synthesis of topically acting sulfonamides incorporating GABA moieties in their molecule, with long-lasting intraocular pressure-lowering properties.. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 9, pp. 185-199, ISSN:0928-0987
C. T. Supuran; A. Scozzafava; L. Menabuoni; F. Mincione; F. Briganti; G. Mincione (1999). Carbonic anhydrase inhibitors. Part 71. Synthesis and ocular pharmacology of a new class of water-soluble, topically effective intraocular pressure lowering sulfonamides incorporating picolinoyl moieties.. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 8, pp. 317-328, ISSN:0928-0987
M. Benvenuti; F. Briganti; A. Scozzafava; L. Golovleva; V. M. Travkin; S. Mangani (1999). Crystallization and preliminary crystallographic analysis of the hydroxyquinol 1,2-dioxygenase from Nocardioides simplex 3E: a novel dioxygenase involved in the biodegradation of polychlorinated aromatic compounds.. ACTA CRYSTALLOGRAPHICA. SECTION D, BIOLOGICAL CRYSTALLOGRAPHY, vol. 55, pp. 901-903, ISSN:0907-4449
A. Scozzafava; L. Menabuoni; F. Mincione; F. Briganti; G. Mincione; C. T. Supuran (1999). Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?. JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, pp. 2641-2650, ISSN:0022-2623
L. Menabuoni; A. Scozzafava; F. Mincione; F. Briganti; G. Mincione; C. T. Supuran (1999). Carbonic anhydrase inhibitors. Water-soluble, topically effective intraocular pressure lowering agents derived from isonicotinic acid and aromatic/heterocyclic sulfonamides: is the tail more important than the ring?. JOURNAL OF ENZYME INHIBITION, vol. 14, pp. 457-474, ISSN:8755-5093
A. Scozzafava;C. T. Supuran (1999). Carbonic anhydrase inhibitors. Arylsulfonylureido- and arylureido-substituted aromatic and heterocyclic sulfonamides: towards selective inhibitors of carbonic anhydrase isozyme I.. JOURNAL OF ENZYME INHIBITION, vol. 14, pp. 343-363, ISSN:8755-5093
M. Barboiu;C. T. Supuran;A. Scozzafava;C. Guran;P. Diaconescu;M. Bojin;V. Iluc;L. Cot (1999). Functionalized Derivatives of Benzo-Crown Ethers. Part 4. Antifungal Macrocyclic Supramolecular Complexes of Transition Metal Ions Acting as Lanosterol-14-alpha-Demethylase Ihibitors.. METAL-BASED DRUGS, vol. 6, pp. 101-110, ISSN:0793-0291
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A. Scozzafava; F. Briganti; C.T. Supuran (1999). Protease inhibitors - Part 3. Synthesis of non-basic thrombin inhibitors incorporating pyridinium-sulfanilylguanidine moieties at the P1 site.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 34, pp. 939-952, ISSN:0223-5234
F. Briganti; A. Scozzafava; C. T. Supuran (1999). Novel carbonic anhydrase isozymes I, II and IV activators incorporating sulfonyl-histamino moieties.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 9, pp. 2043-2048, ISSN:0960-894X
A. Scozzafava; F. Briganti; G. Mincione; L. Menabuoni; F. Mincione; C. T. Supuran (1999). Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, pp. 3690-3700, ISSN:0022-2623
C. T. Supuran; A. Scozzafava; F. Mincione; L. Menabuoni; F. Briganti; G. Mincione; M. Jitianu (1999). Carbonic anhydrase inhibitors. Part 60(#). The topical intraocular pressure-lowering properties of metal complexes of a heterocyclic sulfonamide: influence of the metal ion upon biological activity.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 34, pp. 585-595, ISSN:0223-5234
C. T. Supuran; A. Scozzafava; F. Briganti (1999). Carbonic anhydrase inhibitors: N-cyanosulfonamides, a new class of high affinity isozyme II and IV inhibitors.. JOURNAL OF ENZYME INHIBITION, vol. 14, pp. 289-306, ISSN:8755-5093
C. T. Supuran;A. Scozzafava;F. Briganti;M. A. Ilies;A. Jitianu (1998). Carbonic Anhydrase Inhibitors. Part 55 Metal Complexes of 1,3,4-Thiadiazole-2-Sulfonamide Derivatives: In Vitro Inhibition Studies With Carbonic Anhydrase Isozymes I, II and IV.. METAL-BASED DRUGS, vol. 5, pp. 103-114, ISSN:0793-0291
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C. Guran;M. Barboiu;P. Diaconescu;V. Iluc;M. Bojin;A. Scozzafava;C. T. Supuran (1998). Synthesis and antifungal activity of metal complexes containing dichloro-tetramorpholino-cyclophosphazatriene.. METAL-BASED DRUGS, vol. 5, pp. 287-294, ISSN:0793-0291
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RIDDER L.; F. BRIGANTI ; BOERSMA M.G; BOEREN S; VIS E.H.; A. SCOZZAFAVA; VEEGER C; RIETJENS I.M. (1998). Quantitative structure/activity relationship for the rate of conversion of C4-substituted catechols by catechol-1,2-dioxygenase from Pseudomonas putida (arvilla) C1.. EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 257, pp. 92-100, ISSN:0014-2956
A. Scozzafava;C. Cavazza;C. T. Supuran;I. Saramet;F. Briganti;M. D. Banciu (1998). Complexes with biologically active ligands. Part 11. Synthesis and carbonic anhydrase inhibitory activity of metal complexes of 4,5-disubstituted-3-mercapto-1,2,4-triazole derivatives.. METAL-BASED DRUGS, vol. 5, pp. 11-18, ISSN:0793-0291
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A. Scozzafava;C. T. Supuran (1998). Carbonic anhydrase inhibitors: ureido and thioureido derivatives of aromatic sulfonamides possessing increased affinities for isozyme I. A novel route to 2,5-disubstituted-1,3,4-thiadiazoles via thioureas, and their interaction with isozymes I, II and IV.. JOURNAL OF ENZYME INHIBITION, vol. 13, pp. 103-123, ISSN:8755-5093
F. Mincione; L. Menabuoni; F. Briganti; G. Mincione; A. Scozzafava; C. T. Supuran (1998). Carbonic anhydrase inhibitors: inhibition of isozymes I, II and IV with N-hydroxysulfonamides--a novel class of intraocular pressure lowering agents.. JOURNAL OF ENZYME INHIBITION, vol. 13, pp. 267-284, ISSN:8755-5093
F. BRIGANTI; MANGANI S.; PEDOCCHI L.; SCOZZAFAVA A.; GOLOVLEVA L. A.; A. P. JADAN A. P.; SOLYANIKOVA. I. P. (1998). XAS characterization of the active sites of novel intradiol ring cleaving dioxygenases:hydroxyquinol and chlocatechol dioxygenases. FEBS LETTERS, vol. 433, pp. 58-62, ISSN:0014-5793
A. Scozzafava;C. T. Supuran (1998). Carbonic anhydrase inhibitors: novel compounds containing S-NH moieties: sulfenamido-sulfonamides, sulfenimido-sulfonamides and their interaction with isozymes I, II and IV.. JOURNAL OF ENZYME INHIBITION, vol. 13, pp. 419-442, ISSN:8755-5093
C. T. Supuran;A. Scozzafava;I. Saramet;M. D. Banciu (1998). Carbonic anhydrase inhibitors: inhibition of isozymes I, II and IV with heterocyclic mercaptans, sulfenamides, sulfonamides and their metal complexes.. JOURNAL OF ENZYME INHIBITION, vol. 13, pp. 177-194, ISSN:8755-5093
C. T. Supuran; A. Scozzafava; F. Briganti; G. Loloiu; O. Maior (1998). Sulfonylamido derivatives of 2-aminophenoxathiin-10,10-dioxide and related compounds possess antifungal action due to the possible inhibition of lanosterol-14-alpha-demethylase.. JOURNAL OF ENZYME INHIBITION, vol. 13, pp. 291-310, ISSN:8755-5093
A. Scozzafava;A. Nicolae;O. Maior;F. Briganti;C. T. Supuran (1998). The antifungal activity of 2,2'-diamino-4,4'-dithiazole derivatives is due to the possible inhibition of lanosterol-14-alpha-demethylase.. JOURNAL OF ENZYME INHIBITION, vol. 14, pp. 49-68, ISSN:8755-5093
F. Briganti;S. Mangani;P. Orioli;A. Scozzafava;G. Vernaglione;C. T. Supuran (1997). Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine.. BIOCHEMISTRY, vol. 36, pp. 10384-10392, ISSN:0006-2960
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F. Briganti;E. Pessione;C. Giunta;A. Scozzafava (1997). Purification, biochemical properties and substrate specificity of a catechol 1,2-dioxygenase from a phenol degrading Acinetobacter radioresistens.. FEBS LETTERS, vol. 416, pp. 61-64, ISSN:0014-5793
A. Jitianu;M. A. Llies;F. Briganti;A. Scozzafava;C. T. Supuran (1997). Complexes with biologically active ligands. Part 9 metal complexes of 5-benzoylamino- and 5-(3-nitrobenzoyl-amino)-1,3,4-thiadiazole-2-sulfonamide as carbonic anhydrase inhibitors.. METAL-BASED DRUGS, vol. 4, pp. 1-7, ISSN:0793-0291
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A. SCOZZAFAVA; BRIGANTI F.; GIUNTA C.; PESSIONE E. (1997). Biochemical properties and substrate specificity of a catechol 1,2-dioxygenase from a phenol degrading acinetobacter radioresistens. FEBS LETTERS, vol. 416, pp. 61-64, ISSN:0014-5793, Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598:
V. Lombardi;L. Valko;M. Valko;A. Scozzafava;H. Morris;M. Melnik;J. Svitel;M. Budesinský;J. Pelnár;J. Steno;T. Liptaj;L. Zalibera;J. Budinská;J. Zlatos;A. Giuliani;L. Mascolo;D. Leibfritz;A. Troncone;F. Marzullo;M. Mazur;J. Klener;E. Zverina (1997). 1H NMR ganglioside ceramide resonance region on the differential diagnosis of low and high malignancy of brain gliomas.. CELLULAR AND MOLECULAR NEUROBIOLOGY, vol. 17, pp. 521-535, ISSN:0272-4340
G. Mincione;A. Scozzafava;C. T. Supuran (1997). Carbonic Anhydrase Inhibitors. Part 46 Inhibition of Carbonic Anhydrase Isozymes I, II and IV With Trifluoromethylsulfonamide Derivatives and Their Zinc(II) and Copper(II) Complexes.. METAL-BASED DRUGS, vol. 4, pp. 27-34, ISSN:0793-0291
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F. Briganti;A. Scozzafava;C. T. Supuran (1997). Carbonic Anhydrase Activators. Part 19 Spectroscopic and Kinetic Investigations for the Interaction of Isozymes I and II With Primary Amines.. METAL-BASED DRUGS, vol. 4, pp. 221-227, ISSN:0793-0291
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V. M. Travkin;A. P. Jadan;F. Briganti;A. Scozzafava;L. A. Golovleva (1997). Characterization of an intradiol dioxygenase involved in the biodegradation of the chlorophenoxy herbicides 2,4-D and 2,4,5-T.. FEBS LETTERS, vol. 407, pp. 69-72, ISSN:0014-5793
A. Scozzafava;C. T. Supuran (1997). Complexes With Biologically Active Ligands. Part 10 Inhibition of Carbonic Anhydrase Isozymes I and II With Metal Complexes of Imidazo[2,1-b ]-1,3,4-Thiadiazole-2-Sulfonamide.. METAL-BASED DRUGS, vol. 4, pp. 19-26, ISSN:0793-0291
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C. T. Supuran;A. Scozzafava;A. Jitianu (1997). Carbonic anhydrase inhibitors. Part 54: metal complexes of heterocyclic sulfonamides: a new class of antiglaucoma agents.. METAL-BASED DRUGS, vol. 4, pp. 307-315, ISSN:0793-0291
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C. T. Supuran;A. Scozzafava (1997). Novel aromatic/heterocyclic sulfonamides and their metal complexes as inhibitors of carbonic anhydrase isozymes I, II and IV.. JOURNAL OF ENZYME INHIBITION, vol. 12, pp. 37-51, ISSN:8755-5093
C. T. Supuran;F. Briganti;A. Scozzafava (1997). Sulfenamido-sulfonamides as inhibitors of carbonic anhydrase isozymes I, II and IV.. JOURNAL OF ENZYME INHIBITION, vol. 12, pp. 175-190, ISSN:8755-5093
D. Timotheatou;P. V. Ioannou;A. Scozzafava;F. Briganti;C. T. Supuran (1996). Carbonic Anhydrase Interaction With Lipothioars Enites: A Novel Class of Isozymes I and II Inhibitors.. METAL-BASED DRUGS, vol. 3, pp. 263-268, ISSN:0793-0291
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F. Briganti; R.Pierattelli; A.Scozzafava; C.T.Supuran (1996). Carbonic anhydrase inhibitors. Part 37#. Novel classes of isozymes I and II inhibitors and their mechanism of action. Kinetic and spectroscopic investigations on the native and cobalt-substituted enzymes. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 31, pp. 1001-1010, ISSN:0223-5234
F. Briganti; R. Pierattelli; A. Scozzafava; C.T. Supuran (1996). Carbonic anhydrase inhibitors .37. Novel classes of isozyme I and II inhibitors and their mechanism of action. Kinetic and spectroscopic investigations on native and cobalt-substituted enzymes. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 31, pp. 1001-1010, ISSN:0223-5234
I. Bertini;F. Briganti;A. Scozzafava;C. Luchinat (1996). Dioxygen activation in biodegradation reactions. NOUVEAU JOURNAL DE CHIMIE, vol. 20, pp. 187-193, ISSN:0398-9836
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J. Borràs;J. Casanova;T. Cristea;A. Gheorghe;A. Scozzafava;C. T. Supuran;V. Tudor (1996). Complexes With Biologically Active Ligands. Part 6 Ni(II) Coordination Compounds of Hydrazine and Heterocyclic Sulfonamides as Inhibitors of the Zinc Enzyme Carbonic Anhydrase.. METAL-BASED DRUGS, vol. 3, pp. 143-148, ISSN:0793-0291
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A. SCOZZAFAVA; BRIGANTI F.; NOLTING H.F.; MANGANI S.; BERTINI I (1995). Biophysical investigation of bacterial aromatic extradiol dioxygenases involved in biodegradation processes. COORDINATION CHEMISTRY REVIEWS, vol. 144, pp. 321-345, ISSN:0010-8545, Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598:
I. BERTINI; F. BRIGANTI; A. SCOZZAFAVA (1994). Aliphatic And Aromatic Inhibitors Binding To The Active-Site Of Catechol 2,3-Dioxygenase From Pseudomonas-Putida Mt-2. FEBS LETTERS, vol. 343, pp. 56-60, ISSN:0014-5793
I. BERTINI; F. BRIGANTI; S. MANGANI; H. F. NOLTING; A. SCOZZAFAVA (1994). X-Ray-Absorption Studies On Catechol 2,3-Dioxygenase From Pseudomonas-Putida Mt2. BIOCHEMISTRY, vol. 33, pp. 10777-10784, ISSN:0006-2960
Ciurli S.; Luchinat C.; Scozzafava A. (1994). Iron-sulfur Proteins: Part II. Valence-specific Assignment in Oxidized HiPIP through 1H NMR Spectroscopy.. In: Russo, N., Anastassopoulou, J. and Barone, G.. Properties and Chemistry of Biomolecular Systems, pp. 143-157, Dordrecht: Attuale:KLUWER ACADEMIC PUBL, VAN GODEWIJCKSTRAAT 30, DORDRECHT, NETHERLANDS, 3311 GZ ACM / Association for Computing Machinery:1515 Broadway, 17th Floor:New York, NY 10036:(212)869-7440, EMAIL: acmhelp@hq.acm.org, INTERNET: http://www.acm.org, Fax: (212)944-1318.
MANGANI S; ORIOLI P; SCOZZAFAVA A; L. MESSORI; CARLONI P (1994). EXAFS studies of Fe(III)-phosvitin at high metal to protein ratios.. BIOMETALS, vol. 7, pp. 104-108, ISSN:0966-0844, Rapid Science Publishers:2-6 Boundary Row, London SE1 8HN United Kingdom:011 44 207 9407500, EMAIL: rapidcom@vax.oxford.ac.uk, Fax: 011 44 207 8650027:
I. BERTINI; C. LUCHINAT; R. MACINAI; M. PICCIOLI; A. SCOZZAFAVA; M. S. VIEZZOLI (1994). Paramagnetic Metal Centers In Proteins Investigated Through Heterocorrelated Nmr-Spectroscopy. JOURNAL OF MAGNETIC RESONANCE SERIES B, vol. 104, pp. 95-98, ISSN:1064-1866
F. Cavagna;C. Luchinat;A. Scozzafava;Z. Xia (1994). Polymetallic macromolecules are potential contrast agents of improved efficiency.. MAGNETIC RESONANCE IN MEDICINE, vol. 31, pp. 58-60, ISSN:0740-3194
I. BERTINI; F. BRIGANTI; S. MANGANI; H. F. NOLTING; A. SCOZZAFAVA (1994). Substrate, Substrate-Analog, And Inhibitor Interactions With The Ferrous Active-Site Of Catechol 2,3-Dioxygenase Monitored Through Xas Studies. FEBS LETTERS, vol. 350, pp. 207-212, ISSN:0014-5793
I.Bertini; M.Piccioli; A.Scozzafava; M.S.Viezzoli (1993). Cobalt, Superoxide Dismutase: a reexamination of the 1H NMR spectrum through a novel selectively deuteriated derivative.. MAGNETIC RESONANCE IN CHEMISTRY, vol. 31, pp. S17-S22, ISSN:0749-1581
L. BANCI; I. BERTINI; C. LUCHINAT; M. PICCIOLI; A. SCOZZAFAVA (1993). 1d Versus 2d H-1-Nmr Experiments In Dicopper, Dicobalt Superoxide-Dismutase - A Further Mapping Of The Active-Site. GAZZETTA CHIMICA ITALIANA, vol. 123, pp. 95-100, ISSN:0016-5603
A. Scozzafava;M. S. Viezzoli (1993). The role of the active site amino acid residues on the catalytic activity of Cu2Zn2SOD.. MOLECULAR AND CHEMICAL NEUROPATHOLOGY, vol. 19, pp. 193-204, ISSN:1044-7393
I. Bertini;F. Briganti;L. Calzolai;L. Messori;A. Scozzafava (1993). Selective interaction of ferricyanide with cluster I of Clostridium pasteurianum 2[Fe4S4] ferredoxin.. FEBS LETTERS, vol. 332, pp. 268-272, ISSN:0014-5793
J. C. Beloeil;B. Gillet;O. Fedeli;G. Berenger;V. Lombardi;F. Marzullo;A. Scozzafava (1993). Application of 2D 1H NMR spectroscopy to the study of the brain, spinal cord, and sciatic nerve.. MOLECULAR AND CHEMICAL NEUROPATHOLOGY, vol. 19, pp. 1-13, ISSN:1044-7393
L. BANCI; M. PICCIOLI; A. SCOZZAFAVA (1992). Advances In The Nmr Investigation Of Paramagnetic Molecules In Solution. COORDINATION CHEMISTRY REVIEWS, vol. 120, pp. 1-28, ISSN:0010-8545
I. BERTINI; F. BRIGANTI; C. LUCHINAT; L. MESSORI; R. MONNANNI; A. SCOZZAFAVA; G. VALLINI (1992). H-1-Nmr Studies On Partially And Fully Reduced 2(4fe-4s) Ferredoxin From Clostridium-Pasteurianum. EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 204, pp. 831-839, ISSN:0014-2956
I. BERTINI; F. BRIGANTI; C. LUCHINAT; L. MESSORI; R. MONNANNI; A. SCOZZAFAVA; G. VALLINI (1991). 2d H-1-Nmr Studies Of Oxidized 2(Fe4s4) Ferredoxin From Clostridium-Pasteurianum. FEBS LETTERS, vol. 289, pp. 253-256, ISSN:0014-5793
I. BERTINI; F. BRIGANTI; C. LUCHINAT; A. SCOZZAFAVA; M. SOLA (1991). H-1-Nmr Spectroscopy And The Electronic-Structure Of The High-Potential Iron Sulfur Protein From Chromatium-Vinosum. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 113, pp. 1237-1245, ISSN:0002-7863
L. BANCI; I. BERTINI; F. BRIGANTI; A. SCOZZAFAVA; M. VICENS OLIVER; C. LUCHINAT (1991). H-1 Noe Studies Of Oxidized High-Potential Iron Sulfur Protein-II From Ectothiorhodospira-Halophila. INORGANICA CHIMICA ACTA, vol. 180, pp. 171-175, ISSN:0020-1693
L. BANCI; I. BERTINI; F. BRIGANTI; C. LUCHINAT; A. SCOZZAFAVA; M. VICENS OLIVER (1991). H-1-Nmr Spectra Of Oxidized High-Potential Iron Sulfur Protein (Hipip) From Rhodocyclus-Gelatinosus - A Model For Oxidized Hipips. INORGANIC CHEMISTRY, vol. 30, pp. 4517-4524, ISSN:0020-1669
I. BERTINI; F. BRIGANTI; C. LUCHINAT; A. SCOZZAFAVA (1990). H-1-Nmr Studies Of The Oxidized And Partially Reduced 2(4fe-4s) Ferredoxin From Clostridium-Pasteurianum. INORGANIC CHEMISTRY, vol. 29, pp. 1874-1880, ISSN:0020-1669
W. BAL; I. BERTINI; H. KOZLOWSKI; R. MONNANNI; A. SCOZZAFAVA; G. Z. SIATECKI (1990). The Unusual Behavior Of The Inhibitor S(+)(1-Amino-2-Phenylethyl)Phosphonic Acid Towards Carboxypeptidase-A. JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 40, pp. 227-235, ISSN:0162-0134
I. BERTINI; F. BRIGANTI; R. MONNANNI; A. SCOZZAFAVA; P. CARLOZZI; R. MATERASSI (1990). H-1-Nmr Studies Of Chromatium-Vinosum Cytochrome-C'. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 282, pp. 84-90, ISSN:0003-9861
I. BERTINI; F. BRIGANTI; A. SCOZZAFAVA (1990). Proton Nmr-Spectroscopy Of Flavocytochrome-C552 From Chromatium-Vinosum. INORGANIC CHEMISTRY, vol. 29, pp. 3623-3625, ISSN:0020-1669
I.Bertini; L.Banci; C.Luchinat; A.Scozzafava (1989). Cyanide and azide behave in a similar fashion versus cuprozinc superoxide dismutase.. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 264, pp. 9742-9744, ISSN:0021-9258
L. BANCI; I. BERTINI; C. LUCHINAT; M. PICCIOLI; A. SCOZZAFAVA; P. TURANO (1989). H-1 Noe Studies On Dicopper(II) Dicobalt(II) Superoxide-Dismutase. INORGANIC CHEMISTRY, vol. 28, pp. 4650-4656, ISSN:0020-1669, Amer Chemical Soc:
L.Banci; I.Bertini; C.Luchinat; A.Scozzafava; P.Turano (1989). Binding of fluoride to copper zinc superoxide dismutase.. INORGANIC CHEMISTRY, vol. 28, pp. 2377-2381, ISSN:0020-1669
I.Bertini; J.Hirose; C.Luchinat; L.Messori; M.Piccioli; A.Scozzafava (1988). Kinetic studies on metal removal from transferrins by pyrophosphate. INORGANIC CHEMISTRY, vol. 27(14), pp. 2405-2409, ISSN:0020-1669
I.Bertini; L.Banci; C.Luchinat; R.Monnanni; A.Scozzafava (1988). Water 1H nuclear magnetic relaxation dispersion (NMRD) of Cu2Zn2SOD with some anions and 1H NMR spectra of Cu2Co2SOD in the presence of CN-. INORGANIC CHEMISTRY, vol. 27, pp. 107-109, ISSN:0020-1669
I.Bertini; J.Hirose; H.Kozlowski; C.Luchinat; L.Messori; A.Scozzafava (1988). Effect of nonsynergistic anions on copper transferrin. INORGANIC CHEMISTRY, vol. 27(6), pp. 1081-1086, ISSN:0020-1669
L.Banci; I.Bertini; C.Luchinat; A.Scozzafava (1987). Nuclear relaxation in the magnetic coupled system Cu2Co2SOD, histidine-44 is detached upon anion binding.. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 109(8), pp. 2328-2334, ISSN:0002-7863
L.Banci; I.Bertini; C.Luchinat; R.Monnanni; A.Scozzafava (1987). Characterization of the cobalt(II)-substituted superoxide dismutase-phosphate system. INORGANIC CHEMISTRY, vol. 26(1), pp. 153-156, ISSN:0020-1669
I.Bertini; C.Luchinat; L.Messori; R.Monnanni; A.Scozzafava (1986). The metal binding properties of ovotransferrin: an investigation of cobalt(II) derivatives.. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 261(3), pp. 1139-1146, ISSN:0021-9258
L.Banci; I.Bertini; C.Luchinat; R.Monnanni; A.Scozzafava; B.A.Salvato (1986). A spectroscopic investigation of Co2Zn2- and Co2Co2- superoxide dismutase. GAZZETTA CHIMICA ITALIANA, vol. 116, pp. 51-54, ISSN:0016-5603
I.Bertini; C.Luchinat; L.Messori; A.Scozzafava; G.C.Pellacani; M.Sola (1986). 13C NMR study of the synergistic anion in transferrins. INORGANIC CHEMISTRY, vol. 25(11), pp. 1782-1786, ISSN:0020-1669
I.Bertini; G.Lanini; C.Luchinat; L.Messori; R.Monnanni; A.Scozzafava (1985). Investigation of Cu2Co2SOD and its anion derivatives. 1H NMR and electronic spectra. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 107 (15), pp. 4391-4396, ISSN:0002-7863
I.Bertini; E.Borghi; C.Luchinat; A.Scozzafava (1984). Multinuclear NMR investigation of the metal binding sites of transferrins. JOURNAL OF MOLECULAR STRUCTURE, vol. 113, pp. 191-200, ISSN:0022-2860
I.Bertini; C.Luchinat; R.Monnanni; A.Scozzafava; E.Borghi (1984). Investigation of zinc-deprived bovine superoxide dismutase.. INORGANICA CHIMICA ACTA, vol. 91, pp. 109-111, ISSN:0020-1693
I.Bertini; C.Luchinat; L.Messori; A.Scozzafava (1984). Cobalt(II) as an NMR probe for the investigation of the coordination sites of conalbumin.. EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 141 (2), pp. 375-378, ISSN:0014-2956
I. Bertini;C. Luchinat;A. Scozzafava;A. Maldotti;O. Traverso (1983). Investigation of the coppermagnesiumalkaline phosphatase system. INORGANICA CHIMICA ACTA, vol. 78, pp. 19-22, ISSN:0020-1693
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I. Bertini; C. Luchinat; A. Scozzafava (1983). A comment on anion binding to superoxide dismutase. In: I. Bertini,I. Bertini, R.S. Drago, C. Luchinat. The coordination chemistry of metalloenzymes, pp. 155-158, Dordrecht: D. REIDEL PUBLISHING COMPANY.
I. Bertini;C. Luchinat;R. Monnanni;A. Scozzafava (1982). Different behavior of sulfonamides with respect to copper-substituted bovine and human carbonic anhydrases.. JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 16, pp. 155-160, ISSN:0162-0134
I. Bertini;E. Borghi;C. Luchinat;A. Scozzafava (1981). 2. Binding sites of anions in superoxide dismutase. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 103, pp. 7779-7783, ISSN:0002-7863
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G. Alberti;I. Bertini;C. Luchinat;A. Scozzafava (1981). A new class of inhibitors capable of binding both the acidic and alkaline forms of carbonic anhydrase.. BIOCHIMICA ET BIOPHYSICA ACTA, vol. 668, pp. 16-26, ISSN:0006-3002
I. Bertini;C. Luchinat;F. Mani;A. Scozzafava (1980). Adducts of bis(N-substituted ethylenediamine)copper(II) complexes with hexacyanoferrate(III). INORGANIC CHEMISTRY, vol. 19, pp. 1333-1336, ISSN:1520-510X
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I. Bertini; C. Luchinat; A. Scozzafava (1980). Some structural aspects of carbonic anhydrase. In: C. Bauer, G. Gros, H. Bartels. Biophysics and physiology of carbon dioxide, pp. 151-153, Berlin Heidelberg: SPRINGER-VERLAG.
I. Bertini;C. Luchinat;A. Scozzafava (1980). Superoxide dismutase-thiocyanate: A study of the binding sites of anions on copper(II) in superoxide dismutase. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 102, pp. 7349-7353, ISSN:0002-7863
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I. Bertini;C. Luchinat;A. Scozzafava (1980). The acid-base equilibria of carbonic anhydrase. INORGANICA CHIMICA ACTA, vol. 46, pp. 85-89, ISSN:0020-1693
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G. Canti;A. Scozzafava;G. Ciciani;G. Renzi (1980). Complexes between pilocarpine and cobalt(II), nickel(II), copper(II), and zinc(II) ions.. JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 69, pp. 1220-1222, ISSN:0022-3549
I. Bertini;G. Canti;C. Luchinat;A. Scozzafava (1979). Characterization of oxovanadium(IV) substituted bovine carbonic anhydrase B. INORGANICA CHIMICA ACTA, vol. 36, pp. 9-12, ISSN:0020-1693
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Ivano Bertini;Dante Gatteschi;Andrea Scozzafava (1979). Six-coordinate copper complexes wlth g<g in the solid state. COORDINATION CHEMISTRY REVIEWS, vol. 29, pp. 67-84, ISSN:0010-8545
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D. Barzi; I. Bertini; C. Luchinat; A. Scozzafava (1979). The electronic spectra of cobalt(II) bovine carbonic anhydrase. INORGANICA CHIMICA ACTA, vol. 36, pp. 431-432, ISSN:0020-1693
Ivano Bertini;Paolo Dapporto;Dante Gatteschi;Andrea Scozzafava (1979). Static?dynamic distortions of the tris(1,2-diaminoethane)copper(II) cation [Cu(en)3]2+. Crystal structures of the salts [Cu(en)3][SO4] at 120 K and of [Cu(en)3]Cl2�0.75 en at 298 K. JOURNAL OF THE CHEMICAL SOCIETY DALTON TRANSACTIONS, vol. 9, pp. 1409-1414, ISSN:0300-9246
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I. Bertini;C. Luchinat;A. Scozzafava (1979). 31P NMR spectra of paramagnetic MBr2 (OPPh3)2 complexes. A breakdown in the validity of the Solomon-Bloembergen equations. INORGANIC AND NUCLEAR CHEMISTRY LETTERS, vol. 15, pp. 89-91, ISSN:0020-1650
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I. Bertini;G. Canti;C. Luchinat;A. Scozzafava (1978). Spectroscopic investigation of copper(II) bovine carbonic anhydrase and its inhibitor derivatives. JOURNAL OF THE CHEMICAL SOCIETY DALTON TRANSACTIONS, pp. 1269-1273, ISSN:0300-9246
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Alessandro Bencini;Ivano Bertini;Dante Gatteschi;Andrea Scozzafava (1978). Single-crystal ESR spectra of copper(II) complexes with geometries intermediate between a square pyramid and a trigonal bipyramid. INORGANIC CHEMISTRY, vol. 17, pp. 3194-3197, ISSN:0020-1669
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I. Bertini;G. Canti;C. Luchinat;A. Scozzafava (1978). Characterization of cobalt(II) bovine carbonic anhydrase and of its derivatives. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 100, pp. 4873-4877, ISSN:0002-7863
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I. Bertini;C. Luchinat;A. Scozzafava (1978). Binding affinity of bicarboxylate ions for cobalt (II) bovine carbonic anhydrase.. BIOINORGANIC CHEMISTRY, vol. 9, pp. 93-100, ISSN:0006-3061
I. Bertini;P. Dapporto;D. Gatteschi;A. Scozzafava (1978). X-ray and ESR investigation of an elongated octahedral tris-(1, 2-diaminoethane) copper (II) complex. SOLID STATE COMMUNICATIONS, vol. 26, pp. 749-751, ISSN:0038-1098
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I. Bertini;C. Luchinat;A. Scozzafava (1978). A 31P NMR study of phosphate in presence of cobalt(II)- and copper(II)- substituted bovine carbonic anhydrase B.. FEBS LETTERS, vol. 93, pp. 251-254, ISSN:0014-5793
I. Bertini;C. Luchinat;A. Scozzafava (1978). Evidence of exchangeable protons in the acidic form of manganese(II) bovine carbonic anhydrase B.. FEBS LETTERS, vol. 87, pp. 92-94, ISSN:0014-5793
I. Bertini;C. Luchinat;A. Scozzafava (1977). Carbon-13 longitudinal relaxation times of acetate ion in the presence of metal-substituted bovine carbonic anhydrases. JOURNAL OF THE CHEMICAL SOCIETY DALTON TRANSACTIONS, pp. 1962-1965, ISSN:0300-9246
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I. Bertini;G. Canti;C. Luchinat;A. Scozzafava (1977). Proton relaxation of water solutions containing copper carbonic anhydrase. INORGANICA CHIMICA ACTA, vol. 23, pp. 15-16, ISSN:0020-1693
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I. Bertini;G. Canti;C. Luchinat;A. Scozzafava (1977). Evidence of exchangeable protons in the donor groups of the acidic form of cobalt bovine carbonic anhydrase B.. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 78, pp. 158-160, ISSN:0006-291X
D. Gatteschi;A. Scozzafava (1977). Single crystal polarized electronic spectra of a five-coordinate macrocyclic complex of nickel(II). INORGANICA CHIMICA ACTA, vol. 21, pp. 223-227, ISSN:0020-1693
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I. Bertini;D. Gatteschi;A. Scozzafava (1977). Jahn-Teller distortions of tris(ethylenediamine)copper(II) complexes. INORGANIC CHEMISTRY, vol. 16, pp. 1973-1976, ISSN:0020-1669
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I. Bertini;C. Luchinat;A. Scozzafava (1977). Stereochemistry of cobalt(II) in cobalt bovine carbonic anhydrase and its derivatives. INORGANICA CHIMICA ACTA, vol. 22, pp. 23-24, ISSN:0020-1693
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Bertini I.; Gatteschi D.; Scozzafava A. (1977). Ligand Field Parameters. ISRAEL JOURNAL OF CHEMISTRY, vol. 15, pp. 188--, ISSN:0021-2148
I. Bertini;C. Luchinat;A. Scozzafava (1977). Interaction of cobalt(II) bovine carbonic anhydrase with aniline, benzoate, and anthranilate.. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 99, pp. 581-584, ISSN:0002-7863
I. Bertini;C. Luchinat;A. Scozzafava (1977). Interactions between alpha-amino acids and cobalt(II) bovine-carbonic anhydrase.. BIOINORGANIC CHEMISTRY, vol. 7, pp. 225-231, ISSN:0006-3061
I. Bertini;C. Luchinat;A. Scozzafava (1976). 13C Nmr spectra of hexakis pyridine-N-oxide cobalt(II) and nickel(II) complexes. INORGANICA CHIMICA ACTA, vol. 19, pp. 201-202, ISSN:0020-1693
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I. Bertini;C. Luchinat;A. Scozzafava (1976). Interaction of cobalt-bovine carbonic anhydrase with the acetate ion.. BIOCHIMICA ET BIOPHYSICA ACTA, vol. 452, pp. 239-244, ISSN:0006-3002
Ivano. Bertini;Dante. Gatteschi;Andrea. Scozzafava (1976). Single crystal electronic spectra and ligand field parameters of some nickel(II) amine-isothiocyanato and amine-nitrito complexes. INORGANIC CHEMISTRY, vol. 15, pp. 203-207, ISSN:0020-1669
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I. Bertini;D. Gatteschi;A. Scozzafava (1975). Ligand field interpretation of high-spin trigonal-bipyramidal cobalt(II) complexes. INORGANIC CHEMISTRY, vol. 14, pp. 812-815, ISSN:0020-1669
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I. Bertini;D. Gatteschi;P. Paoletti;A. Scozzafava (1975). A comment on the Jahn-Teller effect in the complex K2PbCu(NO2)6. INORGANICA CHIMICA ACTA, vol. 13, pp. L5-L6, ISSN:0020-1693
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I. Bertini;D. Gatteschi;A. Scozzafava (1975). Single crystal polarized electronic spectra of the complex bis(N-t-butylpyrrole-2-carbaldimino)cobalt(II). INORGANICA CHIMICA ACTA, vol. 13, pp. 145-148, ISSN:0020-1693
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I. Bertini;P. Dapporto;D. Gatteschi;A. Scozzafava (1975). Single-crystal polarized electronic spectra of the pentakis(2-picoline N-oxide)cobalt(II) perchlorate complex. INORGANIC CHEMISTRY, vol. 14, pp. 1639-1643, ISSN:0020-1669
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I. Bertini;D. Gatteschi;A. Scozzafava (1974). Single crystal ESR study of the Cu(en)3SO4 complex. INORGANICA CHIMICA ACTA, vol. 11, pp. L17-L19, ISSN:0020-1693
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Bertini I.; Gatteschi D.; Scozzafava A (1974). Single Crystal ESR Spectra of bis-N t butylpyrrol 2 aldimine Copper(II) Complexes. GAZZETTA CHIMICA ITALIANA, vol. 104, pp. 1029--, ISSN:0016-5603
I. Bertini;D. Gatteschi;A. Scozzafava (1972). Proton magnetic resonance spectra of six-coordinate iron(II), cobalt(II), and nickel(II) complexes with pyridine-n-oxide and benzamide. INORGANICA CHIMICA ACTA, vol. 6, pp. 185-187, ISSN:0020-1693
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Andrea SCOZZAFAVA
Curriculum
Full professor of general and inorganic chemistry at the Faculty of Pharmacy at the University of Florence, he is author of more than 550 pubblications in the following fields 1) spectroscopic and structural characterization of coordination compounds, 2)study of the structure-function relationship in metalloenzymes, 3) isolation and characterization of enzymes involved in biodegradation of aromatic compounds, 4) synthesis of metalloenzymes' inhibitors with potential pharmaceutical applications. The results of his researches has been presented in many international conferences where he has been invited to give session lectures or to organize minisymposia. He gave also conferences in many universities.
He organized in 1995 at Lviv (Ukraine) a NATO-ASI workshop on biotechnological remediation of contaminated sites. He has many research contracts with CNR ( finalized projects on industrial risks and biotechnology) with EU ( two Copernicus projects on bioremediation of contaminated soils, a TMR network on non-heme iron metalloenzymes, one integrated project on targeting new oxigen cascades in anoxic cells, one specific targeted project on integrated technological approach for designing inhibitors of zinc metalloenzymes) and one project financed by Regione Toscana on bioremediation of waste waters from textile industries.
