Personale

Recapiti

Orario di ricevimento

Italiano

Curriculum

Pubblicazioni

Insegnamenti

Flavia VARANO

Ruolo attuale:: Professore Associato
SSD:: CHEM-07/A - Chimica farmaceutica
Afferenza organizzativa:: Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino (NEUROFARBA)

Recapiti

	0554573732
	flavia.varano(AT)unifi.it

Flavia VARANO

Pubblicazioni

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Contributo su rivista |

Articolo su libro |

Libro |

Contributo in atti di convegno (proceeding) |

Brevetto |

Curatela | Altro

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Tesi di Dottorato

Calenda, Sara; Catarzi, Daniela; Varano, Flavia; Vigiani, Erica; Volpini, Rosaria; Lambertucci, Catia; Spinaci, Andrea; Trevisan, Letizia; Grieco, Ilenia; Federico, Stephanie; Spalluto, Giampiero; Novello, Gianluca; Salmaso, Veronica; Moro, Stefano; Colotta, Vittoria (2024). Structural Investigations on 2-Amidobenzimidazole Derivatives as New Inhibitors of Protein Kinase CK1 Delta. PHARMACEUTICALS, vol. 17, pp. 0-0, ISSN:1424-8247 DOI

Spinaci, Andrea; Buccioni, Michela; Catarzi, Daniela; Cui, Chang; Colotta, Vittoria; Dal Ben, Diego; Cescon, Eleonora; Francucci, Beatrice; Grieco, Ilenia; Lambertucci, Catia; Marucci, Gabriella; Bassani, Davide; Pavan, Matteo; Varano, Flavia; Federico, Stephanie; Spalluto, Giampiero; Moro, Stefano; Volpini, Rosaria (2023). “Dual Anta-Inhibitors” of the A2A Adenosine Receptor and Casein Kinase CK1delta: Synthesis, Biological Evaluation, and Molecular Modeling Studies. PHARMACEUTICALS, vol. 16, pp. 0-0, ISSN:1424-8247 DOI

Catarzi, Daniela; Varano, Flavia; Calenda, Sara; Vigiani, Erica; Colotta, Vittoria (2023). Once Upon a Time Adenosine and Its Receptors: Historical Survey and Perspectives as Potential Targets for Therapy in Human Diseases. In: Daniela Catarzi, Flavia Varano, Sara Calenda, Erica Vigiani, Vittoria Colotta. Purinergic Receptors and their Modulators, pp. 1-46 Springer, ISBN:978-3-031-39724-0., vol. 41: DOI

Venturini M.; Cherchi F.; Santalmasi C.; Frulloni L.; Dettori I.; Catarzi D.; Pedata F.; Colotta V.; Varano F.; Coppi E.; Pugliese A.M. (2023). Pharmacological Characterization of P626, a Novel Dual Adenosine A2A/A2B Receptor Antagonist, on Synaptic Plasticity and during an Ischemic-like Insult in CA1 Rat Hippocampus. BIOMOLECULES, vol. 13, pp. 0-0, ISSN:2218-273X DOI

Varano, Flavia; Catarzi, Daniela; Vigiani, Erica; Calenda, Sara; Colotta, Vittoria (2023). Adenosine Receptor Ligands as Potential Therapeutic Agents for Impaired Wound Healing and Fibrosis. In: Flavia Varano, Daniela Catarzi, Erica Vigiani, Sara Calenda, Vittoria Colotta. Purinergic Receptors and their Modulators, pp. 89-99 Springer, ISBN:978-3-031-39724-0., vol. 41: DOI

Catarzi, Daniela; Varano, Flavia; Vigiani, Erica; Lambertucci, Catia; Spinaci, Andrea; Volpini, Rosaria; Colotta, Vittoria (2022). Casein Kinase 1δ Inhibitors as Promising Therapeutic Agents for Neurodegenerative Disorders. CURRENT MEDICINAL CHEMISTRY, vol. 29, pp. 4698-4737, ISSN:0929-8673 DOI

Varano, Flavia; Catarzi, Daniela; Calenda, Sara; Vigiani, Erica; Colotta, Vittoria (2022). CK1 delta inhibition: an emerging strategy to combat neurodegenerative diseases. FUTURE MEDICINAL CHEMISTRY, vol. 14, pp. 1111-1113, ISSN:1756-8919 DOI

Catarzi, Daniela; Varano, Flavia; Vigiani, Erica; Calenda, Sara; Melani, Fabrizio; Varani, Katia; Vincenzi, Fabrizio; Pasquini, Silvia; Mennini, Natascia; Nerli, Giulia; Dal Ben, Diego; Volpini, Rosaria; Colotta, Vittoria (2022). 4-Heteroaryl Substituted Amino-3,5-Dicyanopyridines as New Adenosine Receptor Ligands: Novel Insights on Structure-Activity Relationships and Perspectives. PHARMACEUTICALS, vol. 15, pp. 0-0, ISSN:1424-8247 DOI

Lambertucci, Catia; Marucci, Gabriella; Catarzi, Daniela; Colotta, Vittoria; Francucci, Beatrice; Spinaci, Andrea; Varano, Flavia; Volpini, Rosaria (2022). A2A Adenosine Receptor Antagonists and their Potential in Neurological Disorders. CURRENT MEDICINAL CHEMISTRY, vol. 29, pp. 4780-4795, ISSN:0929-8673 DOI

Varano, Flavia; Catarzi, Daniela; Vigiani, Erica; Dal Ben, Diego; Buccioni, Michela; Marucci, Gabriella; Di Cesare Mannelli, Lorenzo; Lucarini, Elena; Ghelardini, Carla; Volpini, Rosaria; Colotta, Vittoria (2021). Design and Synthesis of Novel Thiazolo[5,4-d]pyrimidine Derivatives with High Affinity for Both the Adenosine A1 and A2A Receptors, and Efficacy in Animal Models of Depression. PHARMACEUTICALS, vol. 14, pp. 0-0, ISSN:1424-8247 DOI

Catarzi D.; Varano F.; Colotta V. (2021). Special issue “adenosine receptors as attractive targets in human diseases”. PHARMACEUTICALS, vol. 14, pp. 1-3, ISSN:1424-8247 DOI

Falsini M.; Ceni C.; Catarzi D.; Varano F.; Dal Ben D.; Marucci G.; Buccioni M.; Marti Navia A.; Volpini R.; Colotta V. (2020). New 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives. Evaluation of different moieties on the 6-aryl ring to obtain potent and selective human A2A adenosine receptor antagonists. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 30, pp. 127126-127126, ISSN:0960-894X DOI Accesso ONLINE all'editore

Varano F.; Catarzi D.; Vincenzi F.; Pasquini S.; Pelletier J.; Lopes Rangel Fietto J.; Espindola Gelsleichter N.; Sarlandie M.; Guilbaud A.; Sevigny J.; Varani K.; Colotta V. (2020). Structural investigation on thiazolo[5,4-d]pyrimidines to obtain dual-acting blockers of CD73 and adenosine A2A receptor as potential antitumor agents. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 30, pp. 127067-127067, ISSN:0960-894X DOI Accesso ONLINE all'editore

Coppi E.; Cherchi F.; Fusco I.; Dettori I.; Gaviano L.; Magni G.; Catarzi D.; Colotta V.; Varano F.; Rossi F.; Bernacchioni C.; Donati C.; Bruni P.; Pedata F.; Cencetti F.; Pugliese A.M. (2020). Adenosine A2B receptors inhibit K+ currents and cell differentiation in cultured oligodendrocyte precursor cells and modulate sphingosine-1-phosphate signaling pathway. BIOCHEMICAL PHARMACOLOGY, vol. 177, pp. 1-7, ISSN:0006-2952 DOI

Ceni C.; Catarzi D.; Varano F.; Ben D.D.; Marucci G.; Buccioni M.; Volpini R.; Angeli A.; Nocentini A.; Gratteri P.; Supuran C.T.; Colotta V. (2020). Discovery of first-in-class multi-target adenosine A2A receptor antagonists-carbonic anhydrase IX and XII inhibitors. 8-Amino-6-aryl-2-phenyl-1,2,4-triazolo [4,3-a]pyrazin-3-one derivatives as new potential antitumor agents. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 201, pp. 0-16, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Varano F.; Catarzi D.; Vigiani E.; Vincenzi F.; Pasquini S.; Varani K.; Colotta V. (2020). Piperazine-and piperidine-containing thiazolo[5,4-d]pyrimidine derivatives as new potent and selective adenosine a2a receptor inverse agonists. PHARMACEUTICALS, vol. 13, pp. 1-19, ISSN:1424-8247 DOI

Catarzi D.; Varano F.; Varani K.; Vincenzi F.; Pasquini S.; Dal Ben D.; Volpini R.; Colotta V. (2019). Amino-3, 5-dicyanopyridines targeting the adenosine receptors. Ranging from pan ligands to combined A1/A2B partial agonists. PHARMACEUTICALS, vol. 12, pp. 159-181, ISSN:1424-8247 DOI Accesso ONLINE all'editore

Falsini M.; Catarzi D.; Varano F.; Ceni C.; Dal Ben D.; Marucci G.; Buccioni M.; Volpini R.; Di Cesare Mannelli L.; Lucarini E.; Ghelardini C.; Bartolucci G.; Menicatti M.; Colotta V. (2019). Antioxidant-Conjugated 1,2,4-Triazolo[4,3-a]pyrazin-3-one Derivatives: Highly Potent and Selective Human A2A Adenosine Receptor Antagonists Possessing Protective Efficacy in Neuropathic Pain. JOURNAL OF MEDICINAL CHEMISTRY, vol. 62, pp. 8511-8531, ISSN:1520-4804 DOI

Varano, Flavia*; Catarzi, Daniela; Falsini, Matteo; Dal Ben, Diego; Buccioni, Michela; Marucci, Gabriella; Volpini, Rosaria; Colotta, Vittoria (2019). Novel human adenosine receptor antagonists based on the 7-amino-thiazolo[5,4-d]pyrimidine scaffold. Structural investigations at the 2-, 5- and 7-positions to enhance affinity and tune selectivity. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 29, pp. 563-569, ISSN:0960-894X DOI Accesso ONLINE all'editore

Varano Flavia, Catarzi Daniela, Colotta Vittoria, Borea Pier Andrea, Vincenzi Fabrizio, Varani Katia (2019). NUOVI TIAZOLO[5,4-d]PIRIMIDIN DERIVATI QUALI AGONISTI INVERSI DEI RECETTORI A2A DELL’ADENOSINA. Numero: 102016000070952 Università degli studi di Firenze 50%, Università degli studi di Ferrara 50%

Falsini, Matteo; Catarzi, Daniela; Varano, Flavia; Dal Ben, Diego; Marucci, Gabriella; Buccioni, Michela; Volpini, Rosaria; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Colotta, Vittoria* (2019). Novel 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives as potent human adenosine A 1 and A 2A receptor antagonists. Evaluation of their protective effect against β-amyloid-induced neurotoxicity in SH-SY5Y cells. BIOORGANIC CHEMISTRY, vol. 87, pp. 380-394, ISSN:0045-2068 DOI Accesso ONLINE all'editore

Fusco I.; Cherchi F.; Catarzi D.; Colotta V.; Varano F.; Pedata F.; Pugliese A.M.; Coppi E. (2019). Functional characterization of a novel adenosine A2B receptor agonist on short-term plasticity and synaptic inhibition during oxygen and glucose deprivation in the rat CA1 hippocampus. BRAIN RESEARCH BULLETIN, pp. 1-7, ISSN:0361-9230 DOI Accesso ONLINE all'editore

Betti, Marco; Catarzi, Daniela; Varano, Flavia; Falsini, Matteo; Varani, Katia; Vincenzi, Fabrizio; Pasquini, Silvia; di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Lucarini, Elena; Dal Ben, Diego; Spinaci, Andrea; Bartolucci, Gian Luca; Menicatti, Marta; Colotta, Vittoria (2019). Modifications on the Amino-3,5-dicyanopyridine Core To Obtain Multifaceted Adenosine Receptor Ligands with Antineuropathic Activity. JOURNAL OF MEDICINAL CHEMISTRY, vol. 62, pp. 6894-6912, ISSN:0022-2623 DOI

Varano, Flavia*; Catarzi, Daniela; Vincenzi, Fabrizio; Falsini, Matteo; Pasquini, Silvia; Borea, Pier Andrea; Colotta, Vittoria; Varani, Katia (2018). Structure-activity relationship studies and pharmacological characterization of N5-heteroarylalkyl-substituted-2-(2-furanyl)thiazolo[5,4-d]pyrimidine-5,7-diamine-based derivatives as inverse agonists at human A2Aadenosine receptor. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 155, pp. 552-561, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Betti, Marco; Catarzi, Daniela; Varano, Flavia; Falsini, Matteo; Varani, Katia; Vincenzi, Fabrizio; Ben, Diego Dal; Lambertucci, Catia; Colotta, Vittoria (2018). The aminopyridine-3,5-dicarbonitrile core for the design of new non-nucleoside-like agonists of the human adenosine A2Breceptor. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 150, pp. 127-139, ISSN:0223-5234 DOI

Flavia, Varano; Vittoria, Colotta; Daniela, Catarzi; Katia, Varani; Pier Andrea Borea, ; Fabrizio, Vincenzi (2018). Novel Thiazolo[4,5-d]pyrimidine derivatives as inverse agonists of A2A adenosine receptors. Numero: WO 2018/007957 Università degli Studi di Firenze, Università degli Studi di Ferrara

Varano, Flavia*; Catarzi, Daniela; Falsini, Matteo; Vincenzi, Fabrizio; Pasquini, Silvia; Varani, Katia; Colotta, Vittoria (2018). Identification of novel thiazolo[5,4-d]pyrimidine derivatives as human A1and A2Aadenosine receptor antagonists/inverse agonists. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 26, pp. 3688-3695, ISSN:0968-0896 DOI Accesso ONLINE all'editore

Bonardi, Alessandro; Falsini, Matteo; Catarzi, Daniela; Varano, Flavia; Di Cesare Mannelli, Lorenzo; Tenci, Barbara; Ghelardini, Carla; Angeli, Andrea; Supuran, Claudiu T.; Colotta, Vittoria* (2018). Structural investigations on coumarins leading to chromeno[4,3-c]pyrazol-4-ones and pyrano[4,3-c]pyrazol-4-ones: New scaffolds for the design of the tumor-associated carbonic anhydrase isoforms IX and XII. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 146, pp. 47-59, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Daniela Catarzi , Flavia Varano, Matteo Falsini , Katia Varani, Fabrizio Vincenzi , Silvia Pasquini , Diego Dal Ben, Vittoria Colotta (2018). Development of novel pyridazinone-based adenosine receptor ligands. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 28, pp. 1484-1489, ISSN:0960-894X DOI

Daniela Poli, ; Matteo Falsini, ; Flavia Varano, ; Marco Betti, ; Katia Varani, ; Fabrizio Vincenzi, ; Anna Maria Pugliese, ; Felicita Pedata, ; Diego Dal Ben, ; Ajiroghene Thomas, ; Ilaria Palchetti, ; Francesca Bettazzi, ; Daniela Catarzi, ; Colotta, Vittoria (2017). Imidazo[1,2-a]pyrazin-8-amine core for the design of new adenosine receptor antagonists: Structural exploration to target the A3 and A2A subtypes. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 125, pp. 611-628, ISSN:1768-3254 DOI

Gessi, Stefania; Bencivenni, Serena; Battistello, Enrica; Vincenzi, Fabrizio; Colotta, Vittoria; Catarzi, Daniela; Varano, Flavia; Merighi, Stefania; Borea, Pier Andrea; Varani, Katia (2017). Inhibition of A2Aadenosine receptor signaling in cancer cells proliferation by the novel antagonist TP455. FRONTIERS IN PHARMACOLOGY, vol. 8, pp. 888-888, ISSN:1663-9812 DOI Accesso ONLINE all'editore

Squarcialupi, Lucia; Betti, Marco; Catarzi, Daniela; Varano, Flavia; Falsini, Matteo; Ravani, Annalisa; Pasquini, Silvia; Vincenzi, Fabrizio; Salmaso, Veronica; Sturlese, Mattia; Varani, Katia; Moro, Stefano; Colotta, Vittoria (2017). The role of 5-arylalkylamino- and 5-piperazino- moieties on the 7-aminopyrazolo[4,3-d]pyrimidine core in affecting adenosine A1 and A2A receptor affinity and selectivity profiles. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 32, pp. 248-263, ISSN:1475-6366 DOI

Falsini, Matteo; Squarcialupi, Lucia; Catarzi, Daniela; Varano, Flavia; Betti, Marco; Di Cesare Mannelli, Lorenzo; Tenci, Barbara; Ghelardini, Carla; Tanc, Muhammet; Angeli, Andrea; Supuran, Claudiu T.; Colotta, Vittoria (2017). 3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold to Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII. JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, pp. 6428-6439, ISSN:0022-2623 DOI Accesso ONLINE all'editore

Fabrizio, Vincenzi; Flavia, Varano; Daniela, Catarzi; Annalisa, Ravani; Enrica, Battistello; Ssilvia, Pasquini; Stefania, Gessi; Stefania, Merighi; P?ier Andrea Borea, ; Vittoria, Colotta; Katia, Varani (2017). Pharmacological characterization of new highly potent A2a adenosine receptor inverse agonissts with antinociceptive activity. In: 2017 Italian-German Purine Club Meeting, springer, pp. 666-666.

Falsini, Matteo; Squarcialupi, Lucia; Catarzi, Daniela; Varano, Flavia; Betti, Marco; Dal Ben, Diego; Marucci, Gabriella; Buccioni, Michela; Volpini, Rosaria; De Vita, Teresa; Cavalli, Andrea; Colotta, Vittoria (2017). The 1,2,4-Triazolo[4,3-a]pyrazin-3-one as a Versatile Scaffold for the Design of Potent Adenosine Human Receptor Antagonists. Structural Investigations to Target the A2A Receptor Subtype. JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, pp. 5772-5790, ISSN:0022-2623 DOI Accesso ONLINE all'editore

Flavia Varano; Daniela Catarzi; Fabrizio Vincenzi; Marco Betti; Matteo Falsini; Annalisa Ravani; Pier Andrea Borea; Vittoria Colotta; Katia Varani (2016). Design, synthesis, and pharmacological characterization of 2‑(2- furanyl)thiazolo[5,4‑d]pyrimidine-5,7-diamine derivatives: new highly potent A2A adenosine receptor inverse agonists with antinociceptive activity. JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, pp. 10564-10576, ISSN:0022-2623

Flavia Varano; Vittoria Colotta; Daniela Catarzi; Katia Varani; Pier Andrea Borea; Fabrizio Vincenzi (2016). Nuovi tiazoli[5,4-d]pirimidin derivati quali agonisti inversi dei recettori A2A dell'adenosina. Flavia Varano; Vittoria Colotta; Daniela Catarzi; Katia Varani; Pier Andrea Borea; Fabrizio Vincenzi

Lucia Squarcialupi ; Daniela Catarzi ; Flavia Varano; Marco Betti; Matteo Falsini; Fabrizio Vincenzi ; Annalisa Ravani; Antonella Ciancetta ; Katia Varani ; Stefano Moro; Vittoria Colotta (2016). Structural refinement of pyrazolo[4,3-d]pyrimidine derivatives to obtain highly potent and selective antagonists for the human A3 adenosine receptor. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 108, pp. 117-133, ISSN:1768-3254

Falsini, M.; Catarzi, D.; Varano, F.; Betti, M.; Dal Ben, D.; Marucci, G.; Buccioni, M.; Volpini, R.; De Vita, T.; Colotta, V. . (2016). 2-Aryl-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives as new potent adenosine human A2A receptor antagonists. In: XXIV National Meeting on Medicinal Chemistry, 10th Young Medicinal Chemists’ Symposium, 11-14 settembre 2016, Perugia., d, pp. 239-239.

Betti, Marco; Colotta, Vittoria; Varano, Flavia; Falsini, Matteo; Varani, Katia; Vincenzi, Fabrizio; Ben, Diego Dal; Pugliese, Annamaria; Catarzi, Daniela (2016). New aminopyridine-3,5-dicarbonitirles as adenosine A2B receptor non-nucleoside agonists.. In: 33rd Camerino-Cyprus Symposium. Receptor Chemistry: reality and vision. 15-19 maggio 2016, Camerino., d, pp. 69-69.

Falsini, Matteo; Squarcialupi, Lucia; Catarzi, Daniela; Varano, Flavia; Betti, Marco; Varani, Katia; Vincenzi, Fabrizio; Ben, Diego Dal; Lambertucci, Catia; Volpini, Rosaria; Colotta, Vittoria (2016). New 5-heteroaryl-pyrazolo[4,3-d]pyrimidin-7-amines as dual human adenosine A1 and A2A receptor antagonists.. In: 33rd Camerino-Cyprus Symposium. Receptor Chemistry: reality and vision. 15-19 maggio 2016, Camerino., d, pp. 78-78.

Betti, M.; Colotta, V.; Varano, F.; Falsini, M.; Varani, K.; Vincenzi, F.; Dal Ben, D.; Di Cesare Mannelli, L.; Zanardelli, M.; Bartolucci, G.; Menicatti, M.; Catarzi, D. (2016). Aminopyridine-3,5-carbonitrile core for the design of new adenosine receptor agonists: structural exploration to target the A1 subtype. In: XXIV National Meeting on Medicinal Chemistry, 10th Young Medicinal Chemists’ Symposium, 11-14 settembre 2016, Perugia., d, pp. 108-108.

Lucia Squarcialupi; Matteo Falsini; Daniela Catarzi; Flavia Varano; Marco Betti; Katia Varani; Fabrizio Vincenzi; Diego Dal Ben; Catia Lambertucci; Rosaria Volpini; Vittoria Colotta (2016). Exploring the 2- and 5-positions of the pyrazolo[4,3-d]pyrimidin-7-amino scaffold to target human A1 and A2A adenosine receptors. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 24, pp. 2794-2808, ISSN:1464-3391

Daniela Catarzi ; Flavia Varano; Daniela Poli ; Lucia Squarcialupi; Marco Betti ; Letizia Trincavelli; Claudia Martini ; Diego Dal Ben ; Ajiroghene Thomas ; Rosaria Volpini ; Vittoria Colotta (2015). 1,2,4-Triazolo[1,5-a]quinoxaline derivatives and their simplified analogues as adenosine A3 receptor antagonists. Synthesis, structure–affinity relationships and molecular modeling studies. BIOORGANIC & MEDICINAL CHEMISTRY, pp. 9-21, ISSN:1464-3391

Flavia Varano; Daniela Catarzi ; Lucia Squarcialupi ; Marco Betti ; Fabrizio Vincenzi ; Annalisa Ravani ; Katia Varani ; Diego Dal Ben ; Ajiroghene Thomas ; Rosaria Volpini ; Vittoria Colotta (2015). Exploring the 7-oxo-thiazolo[5,4-d]pyrimidine core for the design of new human adenosine A3 receptor antagonists. Synthesis, molecular modeling studies and pharmacological evaluation. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, pp. 105-121, ISSN:0223-5234

Betti, Marco; Catarzi, Daniela; Varano, Flavia; Varani, Katia; Lorenzo Di Cesare Mannelli, ; Zanardelli, M.; Ghelardini, Carla; Colotta, Vittoria . (2015). Aminopyridine-3,5-dicarbonitriles as non-nucleoside adenosine A1 receptor agonists.. In: XXIII National Meeting on Medicinal Chemistry, 6-9 settembre 2015, Salerno., d, pp. 132-132.

Squarcialupi, L.; Falsini, M.; Catarzi, D.; Varano, F.; Betti, M.; Di Cesare Mannelli, L.; Zanardelli, M.; Ghelardini, C.; Tanc, M.; Supuran, C.T.; Colotta, V. (2015). 3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new potent and selective inhibitors of the tumor-associated carbonic anhydrase IX and XII.. In: XXIII National Meeting on Medicinal Chemistry, 6-9 settembre 2015, Salerno., d, pp. 131-131.

Catarzi, D.; Colotta, V.; Betti, M.; Falsini, M.; Dal Ben, D.; Marucci, G.; Buccioni, M.; Varano, F. (2015). Thiazolo[5,4-d]pyrimidin-7-amino derivatives as dual human adenosine A2A/A1 receptor antagonists.. In: XXIII National Meeting on Medicinal Chemistry, 6-9 settembre 2015, Salerno., d, pp. 171-171.

D. Catarzi; V. Colotta; F. Varano; L. Squarcialupi; K. Varani (2014). Imidazo[1,2-a]pyrazine core for the design of new adenosine receptor antagonist: optimization of A3 affinity and structural exploration to target the A2A subtype. In: XXV Congresso Nazionale della Società Chimica Italiana, Arcavacata di Rende (CS), 2-12 settembre 2014, d, pp. 347-347.

F. Varano; D. Catarzi; V. Colotta; L. Squarcialupi K. Varani; D. Dal Ben (2014). Exploring the 7-oxo-thiazolo[5,4-d]pyrimidine scaffold for the design of new adenosine A3 receptor antagonists. In: XXV Congresso Nazionale della Società Chimica Italiana, Arcavacata di Rende (CS), 7-12 settembre 2014, d, pp. 373-373.

V. Colotta; L. Squarcialupi; D. Catarzi; F. Varano; R. Volpini; M. Buccioni; D. Dal Ben. (2014). 1,2,4-Triazolo[4,3-a]pyrazin-3-one as a new scaffold to develop potent adenosine receptor antagonists. In: XXV Congresso Nazionale della Società Chimica Italiana, Arcavacata di Rende (CS), 07-12 settembre 2014, d, pp. 350-350.

Flavia Varano; Daniela Catarzi; Vittoria Colotta; Lucia Squarcialupi; Rosanna Matucci (2014). 1,2,4-Benzothiadiazine-1,1-dioxide Derivatives as Ionotropic Glutamate Receptor Ligands: Synthesis and Structure–Activity Relationships. ARCHIV DER PHARMAZIE, pp. 777-785, ISSN:0365-6233 DOI

Lucia Squarcialupi; Vittoria Colotta; Daniela Catarzi; Flavia Varano; Betti Marco; Katia Varani; Fabrizio Vincenzi; Pier Andrea Borea; Nicola Porta; Antonella Ciancetta; Stefano Moro (2014). 7-Amino-2-phenylpyrazolo[4,3-d]pyrimidine derivatives: Structural investigations at the 5-position to target human A1 and A2A adenosine receptors. Molecular modeling and pharmacological studies. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 84, pp. 614-627, ISSN:0223-5234 DOI

Lucia Squarcialupi;Vittoria Colotta;Daniela Catarzi;Flavia Varano;Guido Filacchioni;Katia Varani;Carmen Corciulo;Fabrizio Vincenzi;Pier Andrea Borea;Carla Ghelardini;Lorenzo Di Cesare Mannelli;Antonella Ciancetta;Stefano Moro (2013). 2-Arylpyrazolo[4,3-d]pyrimidin-7-amino Derivatives As New Potent and Selective Human A3Adenosine Receptor Antagonists. Molecular Modeling Studies and Pharmacological Evaluation. JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, pp. 2256-2269, ISSN:0022-2623 DOI

L. Squarcialupi; V. Colotta; D. Catarzi; F. Varano; K. Varani; C. Corciulo; F. Vincenzi; A. Ciancetta; L. Di Cesare Mannelli; C. Ghelardini; S. Moro (2013). Arilpirazolo[4,3-d]pirimidin-7-ammino derivati quali nuovi antagonisti potenti e selettivi del recettore umano A3 dell’adenosina. In: TUMA 2013, Sesto Fiorentino (FI), 1-2-Luglio 2013, d, pp. 60-60.

L. Squarcialupi; V. Colotta; D. Catarzi; F. Varano; K. Varani; F. Vincenzi; D. Sabbadin; S. Moro (2013). Structural investigations on 2-Arylpyrazolo[4,3-d]pyrimidin-7-amino derivatives as new human adenosine receptor antagonists.. In: 22st National Meeting on Medicinal Chemistry, Roma, 10-13 september 2013, d, pp. P.CD.05-P.CD.05.

D. Catarzi; F. Varano; V. Colotta; L. Squarcialupi; R. Matucci; L. di Cesare Mannelli; M.Zanardelli (2013). Synthesis and Pharmacological evaluation of some new 8-substitute-7-trifluoromethyl-4,5-dihydro-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates as AMPA/Kainate receptor antagonists. In: 22st National Meeting on Medicinal Chemistry, Roma, 10-13 september 20013, d, pp. P.CD.03-P. CD. 03.

F. Varano; D. Catarzi; V. Colotta; L. Squarcialupi; K. Varani. (2013). Thiazolo[5,4-d]pyrimidin-7-amino derivatives as new human A2A adenosine receptor antagonists. In: 5th Joint Italian-German Purine Club Meeting, Rimini, 18-21 september 2013, d, pp. 64-64.

D. Catarzi; V. Colotta; F. Varano; L. Squarcialupi; K. Varani; A.M. Pugliese; F. Pedata; I. Palchetti (2013). 2-Arylimidazo[1,2-a]pyrazin-8-amino derivatives as high-affinity fluorescent human A3 adenosine receptor antagonists with potential neuroprotective properties. In: 5th Joint Italian-German Purine Club Meeting, Rimini, 18-21 september 2013, d, pp. 63-64.

V. Colotta; L. Squarcialupi; D. Catarzi; F. Varano; K. Varani; F. Vincenzi; A. Ciancetta; S. Moro (2013). Exploring the effect of 2- and 5-substituents on the pyrazolo[4,3-d]pyrimidin-7-amino derivatives to obtain human adenosine receptor antagonists. In: 5th Joint Italian-German Purine Club Meeting, Rimini, september 18-21 2013, d, pp. 65-66.

F. Varano; D. Catarzi; V. Colotta; L. Squarcialupi; R. Matucci. (2013). 2-Hydroxy-1,2,4-benzothiadiazin-1,1-dioxide derivatives as new antagonists of ionotropic glutamate receptors. In: 22st National Meeting on Medicinal Chemistry, Roma, 10-13 september 2013, d, pp. P.CD.21-P.CD.21.

Daniela Catarzi;Vittoria Colotta;Flavia Varano;Daniela Poli;Lucia Squarcialupi;Guido Filacchioni;Katia Varani;Fabrizio Vincenzi;Pier Andrea Borea;Diego Dal Ben;Catia Lambertucci;Gloria Cristalli (2013). Pyrazolo[1,5-c]quinazoline derivatives and their simplified analogues as adenosine receptor antagonists: Synthesis, structure–affinity relationships and molecular modeling studies. BIOORGANIC & MEDICINAL CHEMISTRY, pp. 283-294, ISSN:0968-0896 DOI

Colotta V;Lenzi O;Catarzi D;Varano F;Squarcialupi L;Costagli C;Galli A;Ghelardini C;Pugliese AM;Maraula G;Coppi E;Pellegrini-Giampietro DE;Pedata F;Sabbadin D;Moro S (2012). 3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new antagonists at ionotropic glutamate receptors: Molecular modeling and pharmacological studies.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, pp. 470-482, ISSN:0223-5234 DOI

V. Colotta; L. Squarcialupi; D. Catarzi; F. Varano; K. Varani; F. Vincenzi; M. Zanardelli; L. Di Cesare Mannelli; C. Ghelardini; S. Paoletta; S. Moro (2012). 2-Arylpyrazolo[4,3-d]pyrimidin-7-amino derivatives, new potent and selective human A3 adenosine receptor antagonists endowed with protective effect against oxaliplatin-induced apoptosis in rat astrocyte cell cultures. In: 21st National Meeting on Medicinal Chemistry, Palermo, 17-20 Luglio 2012, d, pp. 0-0.

D. Poli; D. Catarzi; V. Colotta; F. Varano; G. Filacchioni; S. Daniele; L. Trincavelli; C. Martini; S. Paoletta; S. Moro (2011). The identification of the 2-phenylphthalazin-1(2H)-one scaffold as a new decorable core skeleton for the design of potent and selective human A3 adenosine receptor antagonists.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, pp. 2102-2113, ISSN:1520-4804

D. Catarzi; V. Colotta; F. Varano; K. Varani; S. Paoletta; S. Moro (2011). Novel 8-aroylamini-2-phenylimidazo[1,2-a]pyrazines as human A3 adenosine receptor antagonists. In: XXIV Congresso Nazionale della Società Chimica Italiana, Lecce, 11-16 settembre 2011, d, pp. 385-385.

V. Colotta; D. Catarzi; F. Varano; C. Costagli; C. Ghelardini; A.M. Pugliese; G. Maraula; D. Sabbadin; S. Moro (2011). 3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new antagonists at ionotropic glutamate receptors: molecular modeling and pharmacological studies. In: XXIV Congresso Nazionale della Società Chimica Italiana, Lecce, 11-16 settembre 2011, d, pp. 388-388.

O. Lenzi; V. Colotta; D. Catarzi; F. Varano; L. Squarcialupi; G. Filacchioni; K. Varani; F. Vincenzi; P. A. Borea; D. Dal Ben; C. Lambertucci; G. Cristalli (2011). Synthesis, structure-affinity relationships, and molecular modeling studies of novel pyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, pp. 3757-3768, ISSN:1464-3391

D. Catarzi; O. Lenzi; V. Colotta; F. Varano; D. Poli; G. Filacchioni; K. Lingenhohl; S. Ofner (2010). Pharmacological characterization of some selected 4,5-dihydro-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates and 3-hydroxyquinazoline-2,4-diones as (S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)-propionic acid receptor antagonists.. CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 58, pp. 908-911, ISSN:0009-2363

V. Colotta; F. Capelli; O. Lenzi; D. Catarzi; F. Varano; D. Poli; F. Vincenzi; K. Varani; P.A. Borea; D. Dal Ben; R. Volpini; G. Cristalli; G. Filacchioni (2009). Novel potent and highly selective human A3 adenosine receptor antagonists belonging to the 4-amido-2-arylpyrazolo[3,4-c]quinoline series: molecular docking analysis and pharmacological studies. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 17, pp. 401-410, ISSN:0968-0896

E. Morizzo; V. Colotta; D. Catarzi; F. Varano; S. Federico; G. Spalluto; T. Stockner; S. Moro (2009). G protein-coupled receptors as potential drug target: from receptor topology to rational drug design, an in silico approach. In: Nuove Prospettive in Chimica farmaceutica. III meeting-workshop, Il Ciocco, Castelvecchio Pascoli (LU), 13-14 febbraio 2009, d, pp. 0-0.

O. Lenzi; V. Colotta; D. Catarzi; F. Varano; D. Poli; G. Filacchioni; K. Varani; F. Vincenzi; P. A. Borea; S. Paoletta; E. Morizzo; S. Moro. (2009). 2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a New Scaffold to obtain Potent and Selective Human A3 Adenosine Receptor Antagonists: New Insights into the Receptor-Antagonist Recognition†. JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, pp. 7640-7652, ISSN:0022-2623

F. Varano; D. Catarzi; V. Colotta; D. Poli; G. Filacchioni; A. Galli; C. Costagli (2009). Synthesis and biological evaluation of a new set of pyrazolo[1,5-c]quinazolines as glycine/N-methyl-D-aspartic acid receptor antagonists. CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 57, pp. 826-829, ISSN:0009-2363

V. Colotta; O. Lenzi; D. Catarzi; F. Varano; G. Filacchioni; C. Martini; L. Trincavelli; O. Ciampi; A. M. Pugliese; C. Traini; F. Pedata; E. Morizzo; S. Moro (2009). Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a New Scaffold To Develop Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation, and Ligand-Receptor Modeling Studies.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, pp. 2407-2419, ISSN:0022-2623 DOI

V.COLOTTA; D.CATARZI; F.VARANO; O.LENZI; G.FILACCHIONI; C.MARTINI; L.TRINCAVELLI; O.CIAMPI; C.TRAINI; A.PUGLIESE; F.PEDATA; E.MORIZZO; S.MORO. (2008). Synthesis, ligand-receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, pp. 6086-6102, ISSN:0968-0896 DOI

D. Dal Ben; O. Lenzi; D. Catarzi; F. Varano; F. Vincenzi; K. Varani; P. A. Borea; G. Filacchioni; G. Cristalli; V. Colotta. (2008). Novel 4-amido-2-arylpyrazolo[3,4-c]quinolines as highly potent and selective human adenosine A3 receptor antagonists. Molecular Docking Analysis and Pharmacological Studies.. PURINERGIC SIGNALLING, pp. 15-15, ISSN:1573-9538

F. Varano; D. Catarzi; V. Colotta; O. Lenzi; G. Filacchioni; A. Galli; C. Costagli (2008). Novel AMPA and kainate receptor antagonists containing the pyrazolo[1,5-c]quinazoline ring system: synthesis and structure-activity relationships. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, pp. 2617-2626, ISSN:1464-3391

Daniela CATARZI, Vittoria COLOTTA, Flavia VARANO, Guido FILACCHIONI, Paola GRATTERI, Jacopo SGRIGNANI, Alessandro GALLI, Chiara Costagli (2008). Synthesis and biological evaluation of novel 9-heteroaryl substituted 7-chloro-4,5-dihydro-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates (TQX) as AMPA receptor antagonists.. CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 56, pp. 1085-1091, ISSN:0009-2363 DOI

V. COLOTTA; D. CATARZI; F. VARANO; F. CAPELLI; O. LENZI; G. FILACCHIONI; C. MARTINI; L. TRINCAVELLI; O. CIAMPI; A. PUGLIESE; F. PEDATA; A. SCHIESARO; E. MORIZZO; S. MORO (2007). New 2-Arylpyrazolo[3,4-c]quinoline Derivatives as Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation and Ligand-Receptor Modeling Studies.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 50, pp. 4061-4074, ISSN:0022-2623 DOI

M. BACILIERI; F.VARANO; F.DEFLORIAN; M.MARINI; D.CATARZI; V.COLOTTA; G.FILACCHIONI; A.GALLI; C.COSTAGLI; C.KASEDA; S.MORO (2007). Tandem 3D-QSARs Approach as a Valuable Tool To Predict Binding Affinity Data: Design of New Gly/NMDA Receptor Antagonists as a Key Study.. JOURNAL OF CHEMICAL INFORMATION AND MODELING, vol. 47, pp. 1913-1922, ISSN:1549-9596

E. Morizzo; F. Capelli; O. Lenzi; D. Catarzi; F.Varano; G. Filacchioni; F. Vincenzi; K. Varani; P.A.Borea; V. Colotta; S. Moro. (2007). Scouting Human A3 Adenosine Receptor Antagonist Binding Mode Using a Molecular Simplification Approach: From Triazoloquinoxaline to a Pyrimidine Skeleton as a Key Study. JOURNAL OF MEDICINAL CHEMISTRY, vol. 50, pp. 6596-6606, ISSN:0022-2623

D.CATARZI; V.COLOTTA; F.VARANO. (2007). Competitive AMPA receptor antagonists.. MEDICINAL RESEARCH REVIEWS, vol. 27, pp. 239-278, ISSN:0198-6325

V. Colotta; D. Catarzi; F. Varano; F. Capelli; O. Lenzi; G. Filacchioni; L. Trincavelli; K. Varani; A.M. Pugliese; D. Dal Ben; S. Moro (2007). Progettazione e sintesi di nuovi antagonisti del recettore A3 dell’adenosina: 2-aril-1,2,4-triazolo[4,3-a]quinoxalin-1-oni e loro analoghi strutturali. In: XVIII Convegno Nazionale della Divisione di Chimica Farmaceutica della Società Chimica Italiana. Chieti, Chieti, 16-20 settembre 2007, d, pp. 30-30.

V. COLOTTA; D. CATARZI; F. VARANO; O. LENZI; G. FILACCHIONI; C. COSTAGLI; A. GALLI; C. GHELARDINI; N. GALEOTTI; P.GRATTERI; J.SGRIGNANI; F. DEFLORIAN; S. MORO; (2006). Structural Investigation of the 7-Chloro-3-hydroxy-1H-quinazoline-2,4-dione Scaffold to Obtain AMPA and Kainate Receptor Selective Antagonists. Synthesis, Pharmacological and Molecular Modeling Studies. JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, pp. 6015-6026, ISSN:0022-2623 DOI Accesso ONLINE all'editore

S.MORO; F.VARANO; G.COZZA; M.A.PAGANO; G.ZAGOTTO; A.CHILIN; A.GUIOTTO; D.CATARZI; V.COLOTTA; L.A.PINNA; F.MEGGIO. (2006). Pyrazoloquinazoline tricyclic system as novel scaffold to design new kinase CK2 inhibitors.. LETTERS IN DRUG DESIGN & DISCOVERY, vol. 3, pp. 281-284, ISSN:1570-1808

D.CATARZI; V.COLOTTA; F.VARANO (2006). Competitive Gly/NMDA receptor antagonists. CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 6, pp. 809-821, ISSN:1568-0266

V. Colotta; D. Catarzi; F. Varano; F. Capelli; O. Lenzi; L. Trincavelli; S. Moro (2006). 2- Arylpyrazolo[3,4.c]quinolin-4-acylamines as potent and selective human A3 adenosine receptor antagonists. Synthesis, biological evaluation and molecular modeling studies. PURINERGIC SIGNALLING, pp. 75-75, ISSN:1573-9538

O. LENZI; V. COLOTTA; D. CATARZI; F.VARANO; G. FILACCHIONI; C. MARTINI; L. TRINCAVELLI; OSELE CIAMPI; KATIA VARANI; FEDERICO MARIGHETTI; ERIKA MORIZZO; STEFANO MORO (2006). 4-Amido-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-ones as New Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation and Ligand-Receptor Modeling Studies.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, pp. 3916-3925, ISSN:0022-2623

D. Catarzi; V. Colotta; F. Varano; F. Capelli; O. Lenzi; K. Varani (2006). 2-Arylpyrazolo[3,4.c]quinolin-4-heteroaroylamines as potent and selective human A3 adenosine receptor antagonists. Synthesis and biological evaluation. PURINERGIC SIGNALLING, pp. 74-74, ISSN:1573-9538

D. CATARZI; V. COLOTTA; F. VARANO; O. LENZI; G. FILACCHIONI; L. TRINCAVELLI; C. MARTINI; C. MONOPOLI; S. MORO (2005). 1,2,4-Triazolo[1,5-a]quinoxaline as a versatile tool for the design of selective human A3 adenosine receptor antagonists: synthesis, biological evaluation and molecular modeling studies of 2-(hetero)aryl- and 2-carboxy-substituted derivatives.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, pp. 7932-7945, ISSN:0022-2623

F.VARANO; D. CATARZI; V. COLOTTA; F. R. CALABRI; O. LENZI; G. FILACCHIONI; A. GALLI; C. COSTAGLI; F. DEFLORIAN; S. MORO (2005). 1-Substituted pyrazolo[1,5-c]quinazolines as novel Gly/NMDA receptor antagonists: synthesis, biological evaluation and molecular modeling study. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 13, pp. 5536-5549, ISSN:0968-0896

F.CALABRI; V. COLOTTA; D. CATARZI; F. VARANO; O.LENZI; G. FILACCHIONI; C.COSTAGLI; A. GALLI. (2005). Synthesis and Pharmacological Studies at the Gly/NMDA, AMPA and Kainate Receptors of New Oxazolo[4,5-c]quinolin-4-one derivatives bearing different substituents at position-2 and on the fused benzo ring. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 40, pp. 897-907, ISSN:0223-5234

D.CATARZI; V.COLOTTA; F. VARANO; F.R.CALABRI; O.LENZI; G. FILACCHIONI; L.TRINCAVELLI; C. MARTINI; A.TRALLI; C.MONTOPOLI; S.MORO (2005). 2-Aryl-8-chloro-1,2,4-triazolo[1,5-a]quinoxalin-4-amines as highly potent A1 and A3 adenosine receptor antagonists. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 13, pp. 705-715, ISSN:0968-0896

D. CATARZI; V. COLOTTA; F. VARANO; G.FILACCHIONI; C. MARTINI; L. TRINCAVELLI; A. LUCACCHINI (2004). “1,2,4-TRIAZOLO[1,5-A]QUINOXALINE DERIVATIVES: SYNTHESIS AND BIOLOGICAL EVALUATION AS ADENOSINE RECEPTOR ANTAGONISTS”. IL FARMACO, vol. 59, pp. 71-81, ISSN:0014-827X

F. R. Calabri; V. Colotta; D. Catarzi; F. Varano; O. Lenzi; C. Costagli (2004). Sintesi di nuovi ossazolo[4,5-c]chinolin-oni, variamente sostituiti sul benzene condensato ed in posizione –2, quali antagonisti del recettore Glicina/NMDA. In: XVII Convegno Nazionale della Divisione di Chimica Farmaceutica della Società Chimica Italiana, Pisa, 6-10 settembre 2004, d, pp. 85-85.

D. CATARZI; V. COLOTTA; F. VARANO; F. CALABRI; G. FILACCHIONI; A. GALLI; C. COSTAGLI; A. CARLA'. (2004). Synthesis and biological evaluation of analogues of 7-chloro-4,5-dihydro-4-oxo-8-(1,2,4-triazol-4-yl)-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylic acid (TQX-173) as novel selective AMPA receptor antagonists. JOURNAL OF MEDICINAL CHEMISTRY, vol. 47, pp. 262-272, ISSN:0022-2623

V. COLOTTA; D. CATARZI; F. VARANO; G.FILACCHIONI; C. MARTINI; L. TRINCAVELLI; A. LUCACCHINI (2004). SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF 4-CYCLOALKYLAMINO-1,2,4-TRIAZOLO[4,3-A]QUINOXALIN-1-ONE DERIVATIVES AS A1 AND A3 ADENOSINE RECEPTOR ANTAGONISTS.. ARCHIV DER PHARMAZIE, vol. 337, pp. 35-41, ISSN:0365-6233

F. Varano; V. Colotta; D. Catarzi; F. R. Calabri; O. Lenzi; C. Costagli (2004). Pirazolo[1,5-c]chinazoline 1-carbossi sostituite: nuovi antagonisti del recettore Gly/NMDA. In: XVII Convegno Nazionale della Divisione di Chimica Farmaceutica della Società Chimica Italiana, Pisa, 6-10 settembre 2004, d, pp. 107-107.

D. Catarzi; V. Colotta; F. Varano; F. R. Calabri; O. Lenzi; L. Trincavelli (2004). Derivati a struttura 4-oxo-imidazo[4,5-c]chinolinica quali antagonisti dei recettori Gly/NMDA, AMPA e KA. In: XVII Convegno Nazionale della Divisione di Chimica Farmaceutica della Società Chimica Italiana, Pisa, 6-10 settembre 2004, d, pp. 95-95.

D. Catarzi; V. Colotta; F. Varano; F. R. Calabri; O. Lenzi; S. Moro; C. Montopoli; A. Tralli; L. Trincavelli (2004). Sintesi e relazioni struttura-attività di derivati a struttura 2-aril-8-cloro-1,2,4-triazolo[1,5-a]chinossalinica quali antagonisti potenti e selettivi dei recettori A1 ed A3 dell’adenosina. In: XVII Convegno Nazionale della Divisione di Chimica Farmaceutica della Società Chimica Italiana., Pisa, 6-10 settembre 2004, d, pp. 94-94.

O. Lenzi; V. Colotta; D. Catarzi; F. Varano; F. R. Calabri; L. Trincavelli (2004). 4-N-acilammino e 4-N-sulfonilammino-2-aril-1,2-diidro-1,2,4-triazolo[4,3-a]chinossalin-1-oni: nuovi potenti antagonisti del recettore A3 dell’adenosina. In: XVII Convegno Nazionale della Divisione di Chimica Farmaceutica della Società Chimica Italiana, Pisa, 6-10 settembre 2004, d, pp. 162-162.

V. COLOTTA; D. CATARZI; F. VARANO; F. R. CALABRI; G. FILACCHIONI; C. COSTAGLI; A. GALLI. (2004). “3-Hydroxy-quinazoline-2,4-dione as a useful scaffold to obtain selective Gly/NMDA and AMPA receptor antagonists”. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, pp. 2345-2349, ISSN:0960-894X

D. Catarzi; V. Colotta; F. Varano; F. R. Calabri; O. Lenzi; C. Costagli (2004). 9-Eteroaril-4,5-diidro-4-oxo-1,2,4-triazolo[1,5-a]chinossaline-2-carbossilati antagonisti dei recettori degli amminoacidi eccitatori. In: XVII Convegno Nazionale della Divisione di Chimica Farmaceutica della Società Chimica Italiana, Pisa, 6-10 settembre 2004, d, pp. 96-96.

V. COLOTTA; D. CATARZI; F.VARANO; F. R. CALABRI; O. LENZI; G. FILACCHIONI; C. MARTINI; L. TRINCAVELLI; FRANCESCA DEFLORIAN; STEFANO MORO (2004). The 1,2,4-Triazolo[4,3-a]quinoxalin-1-one Moiety as an Attractive Scaffold to Develop New Potent and Selective Human A3 Adenosine Receptor Antagonists: Synthesis, Pharmacological and Ligand-Receptor Modeling Studies.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 47, pp. 3580-3590, ISSN:0022-2623

V. COLOTTA; D. CATARZI; F. VARANO; G.FILACCHIONI; C. MARTINI; L. TRINCAVELLI; A. LUCACCHINI (2003). Synthesis and structure-activity relationships of a new set of 1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as adenosine receptor antagonists.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11, pp. 3541-3550, ISSN:0968-0896

V. COLOTTA; D. CATARZI; F.VARANO; G. FILACCHIONI; C. MARTINI; L. TRINCAVELLI; A. LUCACCHINI (2003). Synthesis of 4-amino-6-(hetero)arylalkylamino-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent A2A adenosine receptor antagonists.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11, pp. 5509-5518, ISSN:0968-0896

F. Varano; D. Catarzi; V. Colotta; C. Costagli (2002). Synthesis and structure-activity relationships of a new set of 1-substituted-5-oxo-pyrazolo[1,5-c]quinazoline-2-carboxylic acid derivatives as excitatory aminoacid antagonits. DRUGS OF THE FUTURE, pp. 170-170, ISSN:0377-8282

Vittoria Colotta; Daniela Catarzi; Flavia Varano; Letizia Trincavelli. (2002). New 2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-ones as human A3 adenosine receptor antagonists. DRUGS OF THE FUTURE, pp. 187-187, ISSN:0377-8282

D. Catarzi; V. Colotta; F. Varano; C. Costagli (2002). Design and synthesis of a new set of 4-oxo-imidazo[4,5-c]quinolines as ionotropic glutamate receptor antagonists. DRUGS OF THE FUTURE, pp. 171-171, ISSN:0377-8282

F.VARANO; D.CATARZI; V.COLOTTA; G. FILACCHIONI; A.GALLI; C.COSTAGLI; V. CARLA'. (2002). Synthesis and biological evaluation of a new set of pyrazolo[1,5-c]quinazoline-2-carboxylates as novel excitatory amino acid antagonists. JOURNAL OF MEDICINAL CHEMISTRY, vol. 45, pp. 1035-1044, ISSN:0022-2623

Vittoria Colotta; Daniela Catarzi; Flavia Varano; Chiara Costagli (2001). Synthesis and structure-activity relationships of 3-hydroxy-quinazolin-2,4-dione derivatives as glicine/NMDA, AMPA and Kainate receptor antagonists. In: Hungarian-German-Italian-Polish Meeting on Medicinal Chemistry, Budapest, 2-6 september 2001, dd, pp. 62-62.

Daniela Catarzi; Vittoria Colotta; Flavia Varano; Chiara Costagli (2001). 8-Heteroaryl-4,5-dihydro-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylate analogs of TQX-173: selective antagonists of the AMPA receptor. In: Hungarian-German-Italian-Polish Meeting on Medicinal Chemistry, Budapest, 2-6 september 2001, d, pp. 58-58.

F.VARANO; D.CATARZI; V.COLOTTA; L.CECCHI; G. FILACCHIONI; A.GALLI; C. COSTAGLI (2001). Synthesis of a set of ethyl 1-carbamoyl-3-oxoquinoxaline-2-carboxylates and their constrained analogue imidazo[1,5-a]quinoxalines-1,3,4-triones as selective Glycine/NMDA receptor antagonists.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 36, pp. 203-209, ISSN:0223-5234

D.CATARZI; V.COLOTTA; F. VARANO; G. FILACCHIONI; A. GALLI; C.COSTAGLI ; V.CARLA' (2001). Synthesis, Ionotropic glutamate receptor binding affinity and structure-activity relationships of a new set of 4,5-dihydro-8-heteroaryl-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates analogue of TQX-173. JOURNAL OF MEDICINAL CHEMISTRY, vol. 44, pp. 3157-3165, ISSN:0022-2623

Flavia Varano; Daniela Catarzi; Vittoria Colotta; Letizia Trincavelli (2001). Tricyclic heteroaromatic systems. 2-Carboxy-substituted-1,2,4-triazolo[1,5-a]quinoxalines as adenosine receptor antagonists. In: Hungarian-German-Italian-Polish Meeting on Medicinal Chemistry, Budapest, 2-6 september 2001, d, pp. 177-177.

D.CATARZI; V.COLOTTA; F.VARANO; L.CECCHI; G.FILACCHIONI; A.GALLI; C. COSTAGLI; V.CARLA' (2000). 7-Chloro-4,5-dihydro-8-(1,2,4-triazol-4-yl)-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates as novel highly selective AMPA receptor antagonists.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, pp. 3824-3826, ISSN:0022-2623

V. COLOTTA; D. CATARZI; F. VARANO; L.CECCHI; G.FILACCHIONI; C. MARTINI; L. TRINCAVELLI; A. LUCACCHINI (2000). 1,2,4-Triazolo[4,3-a]quinoxalin-1-one: a versatile tool for the synthesis of potent and selective adenosine receptor antagonists.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, pp. 1158-1164, ISSN:0022-2623

Flavia Varano; Daniela Catarzi; Vittoria Colotta; Chiara Costagli (2000). Tricyclic heteroaromatic system. 5,6-dihydro-5-oxo-pyrazolo[1,5-c]quinazolines as excitatory amino acid antagonists. In: XVI International Symposium on Medicinal Chemistry, Bologna, 19-22 settembre 2000, cl, pp. 211-211.

Flavia Varano; Daniela Catarzi; Vittoria Colotta; Chiara Costagli (2000). Synthesis of a set of pyrazolo[1,5-c]quinazolines as novel glycine/NMDA antagonists. In: XVI International Symposium on Medicinal Chemistry, Bologna, september 18-22-2000, cl, pp. 212-212.

V. COLOTTA; D. CATARZI; F.VARANO; L. CECCHI; G. FILACCHIONI; C. MARTINI; L. TRINCAVELLI; A. LUCACCHINI (2000). Synthesis and Structure-Activity Relationships of a new set of 2-arylpyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, pp. 3118-3124, ISSN:0022-2623

Daniela Catarzi; Vittoria Colotta; Flavia Varano; Letizia Trincavelli (2000). 4,5-Dihydro-2-phenyl-1,2,4-triazolo[1,5-a]quinoxaline derivatives as highly potent and selective A3 adenosine receptor antagonists. In: XVI International Symposium on Medicinal Chemistry, Bologna, 19-22 settembre 2000, cl, pp. 174-174.

Vittoria Colotta; Daniela Catarzi; Flavia Varano; Letizia Trincavelli (2000). Benzosubstituted 2-phenyl-1,2,4-triazolo[4,3-a]quinoxalin-1-ones. Synthesis and binding activity on adenosine receptors. In: XVI International Symposium on Medicinal Chemistry, Bologna, 18-22 settembre 2000, cl, pp. 176-176.

Vittoria Colotta; Daniela Catarzi; Flavia Varano; Letizia Trincavelli (2000). 6-Aralkylamino-1,2-dihydro-2-phenyl-1,2,4-triazolo[4,3-a]quinoxalin-1-ones as A2A adenosine receptor antagonists. In: XVI International Symposium on Medicinal Chemistry, Bologna, 18-22 settembre 2000, cl, pp. 175-175.

F. VARANO; D. CATARZI; V. COLOTTA; L. CECCHI; G.FILACCHIONI; A. GALLI; C. COSTAGLI (1999). Synthesis, glycine/NMDA and AMPA binding activity of some new 2,5,6-trioxopyrazino[1,2,3-de]quinoxalines and of their restricted analogs 2,5-dioxo- and 4,5-dioxoimidazo[1,5,4-de]quinoxalines.. ARCHIV DER PHARMAZIE, vol. 332, pp. 201-207, ISSN:0365-6233

Daniela Catarzi; Vittoria Colotta; Flavia Varano; Chiara Costagli (1999). 4-Oxo-1,2,4-triazolo[1,5-a]quinoxalin-2-carboxylic acid derivatives: antagonists of the Glycine/NMDA and AMPA receptors.. In: Italian-Hungarian-Polish Joint Meeting on Medicinal Chemistry, d, pp. 216-216.

Vittoria Colotta; Daniela Catarzi; Flavia Varano; Letizia Trincavelli (1999). 1,2,4-triazolo[4,3-a]quinoxalin-1-one as a framework to obtain potent and selective A1, A2A and A3 adenosine receptor antagonists. In: Italian-Hungarian-Polish Joint Meeting on Medicinal Chemistry, Giardini Naxos Taormina, d, pp. 225-225.

D. CATARZI; V. COLOTTA; F. VARANO; L. CECCHI; G. FILACCHIONI; A. GALLI; C. COSTAGLI (1999). 4,5-Dihydro-1,2,4-triazolo[1,5-a]quinoxalin-4-ones. Excitatory amino acid antagonists with combined glycine/NMDA and AMPA receptor affinity. JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, pp. 2478-2484, ISSN:0022-2623

V. COLOTTA; D. CATARZI; F. VARANO; L. CECCHI; G. FILACCHIONI; C. MARTINI; L. TRINCAVELLI; A. LUCACCHINI (1999). 4-Amino-6-benzylamino-1,2-dihydro-2-phenyl-1,2,4-triazolo[4,3-a] quinoxalin-1-one: a new A2A adenosine receptor antagonist with high selectivity versus A1 receptors.. ARCHIV DER PHARMAZIE, vol. 332, pp. 39-41, ISSN:0365-6233

F. VARANO; D. CATARZI; V. COLOTTA; L. CECCHI; G.FILACCHIONI; A. GALLI; C. COSTAGLI (1998). Synthesis of 2-substituted-3,4-dihydro-3-oxo-6,8-dichloro-2H-1,4-benzothiazin-1,1-dioxides and 1-oxides as glycine-NMDA receptor antagonists.. IL FARMACO, vol. 53, pp. 752-757, ISSN:0014-827X

V. COLOTTA; D. CATARZI; F. VARANO; L. CECCHI; G. FILACCHIONI; C. MARTINI; L. GIUSTI; A. LUCACCHINI (1998). Tricyclic heteroaromatic systems. Synthesis and benzodiazepine receptor affinity of 2-substituted-1-benzopyrano[3,4-d]oxazol-4-ones, -thiazol-4-ones, and –imidazol-4-ones.. IL FARMACO, vol. 53, pp. 375-381, ISSN:0014-827X

V. COLOTTA; D. CATARZI; F. VARANO; F. MELANI; G.FILACCHIONI; L. CECCHI; L. TRINCAVELLI; C. MARTINI; A. LUCACCHINI (1998). Synthesis and A1 and A2A binding activity of some pyrano[2,3-c]pyrazol-4-ones.. IL FARMACO, vol. 53, pp. 189-196, ISSN:0014-827X

D. CATARZI; V. COLOTTA; F. VARANO; L. CECCHI; G.FILACCHIONI; A. GALLI; C. COSTAGLI (1997). Tricyclic heteroaromatic systems. Pyrazolo[3,4-c]quinolin-4-ones and pyrazolo[3,4-c]quinoline-1,4-diones: synthesis and benzodiazepine receptor activity.. ARCHIV DER PHARMAZIE, vol. 330, pp. 383-386, ISSN:0365-6233

F. VARANO; D. CATARZI; V. COLOTTA; L. CECCHI; G. FILACCHIONI; A. GALLI; C. COSTAGLI. (1997). Tricyclic Heteroaromatic systems. 3-Substituted 1,2,3,5,6,7-hexahydro-2,5,6-trioxopyrazino[1,2,3-de]quinoxalines as novel antagonists at the glycine-NMDA site.. IL FARMACO, vol. 52, pp. 179-182, ISSN:0014-827X

V. COLOTTA; D. CATARZI; F. VARANO; L. CECCHI; G.FILACCHIONI; A. GALLI; C. COSTAGLI (1997). Synthesis and biological evaluation of a series of quinazoline-2-carboxylic acids and quinazolin-2,4-diones as glycine-NMDA antagonists: a pharmacophore model based approach.. ARCHIV DER PHARMAZIE, vol. 330, pp. 129-134, ISSN:0365-6233

V. COLOTTA; D. CATARZI; F. VARANO; L. CECCHI; G. FILACCHIONI; A. GALLI; C. COSTAGLI. (1997). Tricyclic heteroaromatic systems. 1,2,4-triazolo[4,3-a]quinoxalines and 1,2,4-triazino[4,3-a]quinoxalines: synthesis and central benzodiazepine receptor activity.. ARCHIV DER PHARMAZIE, vol. 330, pp. 387-391, ISSN:0365-6233

F. VARANO; D. CATARZI; V. COLOTTA; L. CECCHI; G.FILACCHIONI; A. GALLI; C. COSTAGLI (1996). Structure-activity relationship studies of novel pyrazolo[1,5-c][1,3]benzoxazines: synthesis and benzodiazepine receptor affinity.. ARCHIV DER PHARMAZIE, vol. 329, pp. 529-534, ISSN:0365-6233

V. COLOTTA; D. CATARZI; F. VARANO; L. CECCHI; G.FILACCHIONI; A. GALLI; C. COSTAGLI (1996). Synthesis and binding activity of some pyrazolo[1,5-c]quinazolines as tools to verify an optional binding site of a benzodiazepine receptor ligand.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 39, pp. 2915-2921, ISSN:0022-2623

V. COLOTTA; D. CATARZI; F. VARANO; F. MELANI; G.FILACCHIONI; L. CECCHI; A. GALLI; C. COSTAGLI (1996). Benzodiazepine binding activity of some tricyclic heteroarometic systems to define the hydrogen bonding strength of the proton donors of the receptor site.. IL FARMACO, vol. 51, pp. 223-229, ISSN:0014-827X

Daniela Catarzi; Lucia Cecchi; Vittoria Colotta; Guido Filacchioni; Flavia Varano (1995). Hydrogen bonding power and benzodiazepine receptor affinity relationships of 2-phenyl and 2-carbethoxy- tricyclic derivatives. In: 10th Camerino-Noordwijkerhout Symposium, Camerino, 10-14 settembre 1995, Università di Camerino, pp. 191-192.

D. CATARZI; L. CECCHI; V. COLOTTA; G. FILACCHIONI; F. VARANO; C. MARTINI; L. GIUSTI; A. LUCACCHINI (1995). SYNTHESIS OF SOME 2-ARYL-1,2,4-TRIAZOLO[1,5-C][1,3]BENZOXAZIN-5-ONES AS TOOLS TO DEFINE THE ESSENTIAL PHARMACOPHORIC DESCRIPTORS OF A BENZODIAZEPINE RECEPTOR LIGAND.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 38, pp. 2196-2201, ISSN:0022-2623