Codice Fiscale

Massimo PISTOLESI - Curriculum Vitae

1. PERSONAL INFORMATION

  Date of birth: August 1, 1948

Place of birth: Pisa, Italy

Home address: via delle Mantellate, 4  50129 Firenze (Italy) tel. +39 055 496875

  Present appointment:     Professor of Respiratory Medicine,

                                      Department of Experimental and Clinical Medicine,

                                      University of Florence (from 1997)

  Past appointments:        Career Investigator,  National Research Council (CNR),

                                      Pulmonary Unit, Institute of Clinical Physiology, Pisa (1975-87)                                    

                                      Associate Professor of Respiratory Pathophysiology,

                                      Department of Internal Medicine,

                                      University of Rome (1988-91)

                                      Associate Professor of Respiratory Pathophysiology,

                                      Cardio-Thoracic Department,

                                      University of Pisa (1991-97)

Address: Section of Respiratory Medicine,

                Department of Internal Medicine,

                University of Florence

                Viale Morgagni, 85

                50134 Firenze (Italy)

tel: +39 055 413183 - +39 055 4277516  fax: +39 055 4223202   portable: +39 329 6117036

e-mail: massimo.pistolesi@unifi.it

2. EDUCATION, DEGREES, AND ACADEMIC CAREER 

1963-67        Scientific High School "G. Marconi", San Miniato (Pisa).

1967-73        School of Medicine and Surgery, Catholic University, Rome.

                     Student internships:

                     Physiology (1970-71)

                     Respiratory Medicine (1971-73)

                     M.D. graduation with honours

M.D. Graduation thesis: Effects of bronchodilators on the ventilation/perfusion ratio in asthma and COPD.

1973-75        EURATOM Research Fellowship, Pulmonary Unit, National Research Council (CNR) Institute of Clinical Physiology, Pisa.

                       Postgraduated School of Pulmonary Diseases, University of Pisa.

                     Board certified in Pulmonary Diseases (1975).

1975-87        Career Investigator of the National Research Council (CNR), Pulmonary Unit,             Institute of Clinical Physiology, Pisa.

                       Postgraduated School of Nuclear Medicine, University of Pisa.

                     Board certified in Nuclear Medicine (1977).

                     Visiting Associate Professor, Department of Radiological Sciences, University of             California, Irvine, USA (1982). 

1987-91        Associate Professor of Respiratory Pathophysiology, Department of Internal                      Medicine, University of Rome.

1991-97        Associate Professor of Respiratory Pathophysiology, Cardio-Thoracic Department, University of Pisa.

 from 1997    Professor of Respiratory Medicine, Department of Experimental and Clinical Medicine,

                    University of Florence.

3. TEACHING ACTIVITY

1978-87          Lecturer of Respiratory Medicine and Chest Imaging,

                   School of Medicine and Postgraduate School of Respiratory Diseases,

                   University of Pisa.

                   Lecturer in Chest Radiology, Departments of Radiological Sciences and Medicine, University of California, Irvine, USA (1982).

1988-91     Course of Respiratory Medicine, School of Medicine, University of Rome.

1989-97     Ph.D. Course of Cardiorespiratory Pathophysiology, Universities of Rome,                    L'Aquila, and Pisa.                              

1991-97     Course of Respiratory Pathophysiology, School of Medicine, University of Pisa.

Lecturer, Postgraduate Schools of

Respiratory Diseases,

Anesthesiology and Intensive Care, 

Endocrinology,

University of Pisa.

from 1997  Course of Respiratory Medicine,

School of Medicine,

School of Obstetrics,

School of Biotechnology,

School of Sciences and Techniques of Sports,

School of Neurophysiopathology

University of Florence.

Lecturer, Postgraduate Schools of

Respiratory Diseases,

Internal Medicine,

Cardiology,

Thoracic Surgery,

Anesthesiology

Gastroenterology,

Sports Medicine,

Endocrinology,

Physical Therapy,

University of Florence.

Coordinator of the Cardiovascular and Pulmonary (medical and surgical)

teaching programs, School of Medicine, University of Florence.

                     Ph.D. Course of Applied Pathophysiology, University of Florence.

                    Lecturer, Postgraduate School of Respiratory Diseases, University of Pisa.

from 2008  Director of the Postgraduate School of Respiratory Medicine, University of Florence,

                    Pisa and Siena.

4. CLINICAL ACTIVITY

1973-78                        Internship in the wards and diagnostic laboratories of the Pulmonary Unit,

CNR  Institute of Clinical Physiology and in the Service of Respiratory Pathophysiology,   Medical Clinics, University of Pisa.

1978-88                        Associate Director of the wards (above institutions).

                           Consultant of Respiratory Medicine and Chest Radiology,

                           Medical and Surgical Intensive Care Units,

                           University of California Irvine Medical Center, California, USA (1982).

1988-91                        Director of the Service of Respiratory Pathophysiology,

                           Department of Internal Medicine, University of Rome.

1991-97                        Director of the Pulmonary Intensive Care Unit,

                           CNR Institute of Clinical Physiology, Pisa.

                           Associate Director of the Respiratory wards, Cardio-Thoracic Department,          University of Pisa.

                           Director of the Service of Respiratory Emergencies,

                           University Hospital of Pisa.

from 1997         Director of the Section of Respiratory Medicine,

                           Department of Internal Medicine, University of Florence.

                           Head of the Pulmonology and Respiratory Pathophysiology

                           Careggi University Hospital, Florence

5. SCIENTIFIC ACTIVITY

A)   Research fields

                           1) Diagnosis and pathophysiology of pulmonary edema

                           2) Diagnosis and pathophysiology of COPD and asthma

                           3) Functional interpretation of chest radiography

                           4) Physiology and pathophysiology of pleural liquid exchange

                           5) Non-respiratory (metabolic) functions of the lung

                           6) Diagnosis of pulmonary embolism

                           7) Noninvasive measurement of cardiac output

                           8) Defense mechanisms of the airways

B)    Research grants

1973-1980      Research projects "Application of radioisotopes to the study of the central                        circulation" and "Exposure to radiations in pulmonary diagnostic procedures"   founded by Euratom, Free University of Bruxelles, Royal Postgraduate Medical          School of London, and University of Pisa.

1980-1991      Research projects "Hydrostatic and injury lung edema", "Compton-scattering       tomography", and "Metabolic functions of the lung" founded by the National         Research Council of Italy (CNR).

                       Research project "Evaluation of Pulmonary Edema" founded by the National Science      Foundation of USA and the University of California, Irvine, USA.

1991-1998      Research projects "Chest radiography in the early detection of airways obstruction in           a sample of the general population", "Noninvasive indicators of lung cellular damage", and "Urinary escretion of desmosine to evaluate lung elastine turnover in     patients with COPD" founded by the National Research Council of Italy (CNR).

Research project "Diagnosis of pulmonary embolism" founded by the Ministry of Health and the Ministry of Education of Italy.

                       Research project "Evaluation of Aminosteroids in the therapy of injury lung edema" founded by the Ministry of Education of Italy and the Upjohn Co.

1995-2005       Research project "Surgical treatment of emphysema" founded by the Paola Piaggio   Foundation.

1997-2001       Research project "Defense mechanisms of the airways" founded by the Ministry

of Education of Italy.

2001-2003    National coordinator of the research project "Mechanics and control of respiration

in physiologic and pathophysiologic conditions" founded by the Ministry of Education of Italy.

  2004-2008   Research project "Predominant phenotypes of smokers with COPD: functional,  biological, and radiological characterization" founded by the Ministry of Education of Italy".

                        Research project " Smoking, cough, and COPD" and "Bayesan approach to the diagnosis of pulmonary embolism" founded by the Ministry of Health of Italy.

                        Research project "Clinical phenotypes of COPD" founded by the Ministry of Health of Italy.

 2009-2010  Research project "Ottimizzazione delle strategie preventive, diagnostiche e terapeutiche nella broncopneumopatia cronica ostruttiva (BPCO) "  founded by the Ministry of Health of Italy.

2012-2014   Research Project "Ambulung" in cooperation with Novalung (Germany), Imperial College (UK), Karolinska Institute (Sweden) founded by the European Commission  

C) Assignments

1983-87          Member of the Scientific Council of the CNR Institute of Clinical Physiology, Pisa.

1983-91          Secretary of the Advisory Committee on Cardiopulmonary Research of the National         Research Council of Italy.

1985-98          Member of the Editorial Board of the "Journal of Thoracic Imaging".

1986-90          Member of the Scientific Council of the CNR Institute for the Study of the                        Pathophysiology of Shock, Rome.

1987-91          Member of the Council and Secretary-Treasurer of the Italian Society of Nuclear          Medicine and Biology.

1992, 1997     Chairman of the Committee for the selection of new members of the Fleischner      Society for Chest Diagnosis.

from 1990      Reviewer for the

                       American Journal of Respiratory and Critical Care Medicine,

                       Chest,

                       European Respiratory Journal,

                       Thorax,

                       Respiration,

                       Respiratory Research,

                       Monaldi Archives for Chest Diseases,

                       Journal of Applied Physiology

                       Journal of Internal Medicine,

                       Internal and Emergency Medicine

                       Quarterly Journal of Nuclear Medicine,

                       Clinical Physiology and Functional Imaging,

                       Journal of Nuclear Medicine

                       Radiology.

2005               Chairman of the Organizing Committee of the 1^st World Congress of Thoracic Imaging and Diagnosis of Chest Disease (Florence, May 7-10, 2005).

from 2005      Chairman of the Committee of Academic Development of the Fleischner Society.

from 2010      Member of  the National Commission of Health Research of the Ministry of Health of Italy

2010-11          President of the Fleischner Society

from 2011      member of the Administrative Council of the Gabriele Monasterio Foundation, Pisa  (Tuscany region health system and National Research Council (CNR) of Italy).

from 2013-     Vice-Director of the Department of Experimental and Clinical Medicine of the University of Florence    

   D) Honors and Awards

1983                    Cum laude citation Scientific Exhibit, Annual Meeting of the Radiological Society           of North America, Chicago, USA.

1986                    Election to membership of the Fleischner Society for Chest Diagnosis.

                            Scientific Society, founded in 1969 in Boston in the memory of the chest radiologist Felix       Fleischner of the Harvard University Medical School. The Society is composed by 60 members              (chest radiologists, pulmonologists, thoracic surgeons, intensive care physicians). The members            are elected on the basis of the international recognition of their significant and continuing                 contributions to the diagnosis of chest diseases with particular emphasis on imaging.

1987                    "Luigi Pigorini" Award of the Italian Society of Medical Radiology.

1988                    "Manfredi del Buono" Award and Memorial Lecture, University of Zurich, Switzerland

E) Scientific Societies

-  Fleischner Society for Chest Diagnosis

-  American Thoracic Society

-  European Respiratory Society

-  Associazione Italiana di Medicina Nucleare

-  Società Italiana di Medicina Respiratoria

-  Associazione Italiana Pneumologi Ospedalieri

-  Associazione Interdisciplinare Malattie Apparato Respiratorio

-  Fellow of the American College of Chest Physician

G) SCIENTIFIC PUBLICATIONS

Co-author of more than 400 publications in domestic and foreign journals, books, book chapters, and proceedings of congresses.

Publications in journals with editorial board, books, and chapters in international books (selection listed in chronological order) 

1) Giuntini C, Santolicandro A, Pistelli G, Pistolesi M, Ianni A, Angeletti CA: Evolution of physiologic findings in a patient with bronchial adenoma treated by conservative bronchial surgery. Journal of Nuclear Biology and Medicine 1975; 19:105-111.

2) Pollastri A, Pistolesi M, Giuntini C: A method for computing frequency functions from input-output vascular dilution curves. Journal of Nuclear Medicine and Allied Sciences 1977; 21:165-172.

3) Pistolesi M, Guzzardi R, Solfanelli S, Mey M, Giuntini C: Regional lung density imaging by 90° scattering of an external gamma ray source. In: Proceedings of the San Diego Biomedical Symposium, Martin JI, ed., New York,  USA, Academic Press, 1977, pp. 45-54.

4) Pistolesi M, Solfanelli S, Guzzardi R, Mey M, Giuntini C: Chest tomography by gamma-camera and external gamma-source. Journal of Nuclear Medicine 1978; 19:94-97.

5) Guzzardi R, Mey M, Pistolesi M, Solfanelli S, Giuntini C: The 90° Compton scattering tomography of the lung. Journal of Nuclear Medicine and Allied Sciences 1978; 22:11-19.

6) Pistolesi M, Giuntini C: Assessment of extravascular lung water. Radiologic Clinics of North America 1978; 16:551-574.

7) Giuntini C, Guzzardi R, Pistolesi M, Mey M, Solfanelli S: Evaluation of a system for 90° Compton scattering in lung tomography. Progress in Respiration Research 1979; 11:76-85.

8) Ballestra AM, Pistolesi M, Maseri A, Giuntini C: Mechanisms of arterial hypoxemia in acute myocardial infarction. In: Cardiac Lung, Giuntini C, Panuccio P, eds., Padova, Piccin Medical Books, 1979, pp. 301-316.

9) Giuntini C, Pistolesi M, Pollastri A, Begliomini E, Ballestra AM, Maseri A: Chest x-ray versus dilution method in the assessment of pulmonary edema in patients with coronary artery disease. In: Cardiac Lung, Giuntini C, Panuccio P, eds., Padova, Piccin Medical Books, 1979, pp. 251-262.

10) Pistolesi M, Miniati M, Ravelli V, Giuntini C: Injury versus hydrostatic lung edema: detection by chest x-ray. Annals of the New York Academy of Sciences 1982; 384:364-380.

11) Pistolesi M, Miniati M, Solfanelli S, Giuntini C, Azzarelli L, Chimenti M, Denoth F, Fabbrini F: Tomographic imaging of regional lung density by 90° Compton scattering. In: Computers in Critical Care and Pulmonary Medicine, Prakash O, ed, New York, USA, Plenum Press Corp.,1982, pp. 41-43.

12) Miniati M, Pistolesi M, Solfanelli S, Giuntini C, Azzarelli L, Chimenti M, Denoth F, Fabbrini F: Lung density imaging in pulmonary edema: chest x-ray versus Compton scatter tomography. In: Computers in Cardiology 1981, Long Beach,  USA, IEEE Computers Society, 1982, pp. 69-74.

13) Azzarelli L, Chimenti M, Denoth F, Fabbrini F, Pistolesi M, Miniati M, Solfanelli S, Giuntini C: Computer analysis of Compton scattering images: acquisition, restoration and application in patients with pulmonary oedema. In: Optics in Biomedical Sciences, von Bally G, Greggus P, eds., New York, USA, Springer, 1982, pp. 62-65.

14) Giuntini C, Miniati M, Pistolesi M, Gerundini P, Gilardi MC, Fazio F: Differential diagnosis of lung injury and hydrostatic oedema. European Journal of Respiratory Diseases 1983; 64 (suppl 126): 159-165.

15) Giuntini C, Pistolesi M, Miniati M: Chest radiographic patterns of R.D.S. in adult patients. In Pulmonary Surfactant System, Cosmi EV, Scarpelli EN, eds., Amsterdam,  Holland, Elsevier Biomedical Press, 1983, pp. 273-286. 

16) Miserocchi G, Pistolesi M, Miniati M, Bellina CR, Negrini D, Giuntini C: Pleural liquid pressure gradients and intrapleural distribution of injected bolus. Journal of Applied Physiology 1984; 56: 526-532.

17) Milne ENC, Pistolesi M, Miniati M, Giuntini C: The vascular pedicle of the heart and the vena azygos. Part I: the normal subject. Radiology 1984; 152:1-8.

18) Pistolesi M, Milne ENC, Miniati M, Giuntini C: The vascular pedicle of the heart and the vena azygos. Part II: acquired heart disease. Radiology 1984; 152:9-17.

19) Milne ENC, Imray TJ, Pistolesi M, Miniati M, Giuntini C: The vascular pedicle and the vena azygos. Part III: in trauma- the vanishing azygos. Radiology 1984; 153:25-31.

20) Ruschi S, Pedreschi M, Pistolesi M, Miniati M, Santolicandro A: Evaluation of regional lung function by radioisotopic techniques in the follow-up of chronic bronchitis. Journal of Nuclear Medicine and Allied Sciences 1984; 28:136-141.

21) Miniati M, Pistolesi M, Pollastri A, Begliomini E, Giuntini C: Special procedures in the determination of extravascular lung water: input-output sampling, computer analysis and modelling. Beitrage zur Anaesthesiologie und Intensivmedizin 1984; 6:60-70.

22) Pistolesi M, Miniati M, Milne ENC, Ravelli V, Lutzemberger L, Giuntini C: La radiographie du thorax dans les cas de detresse respiratoire chez l'adulte. Radiologie J CEPUR 1985; 5:143-149.   

23) Mussi A, Janni A, Pistolesi M, Ravelli V, Buonaguidi R, Angeletti CA: Surgical treatment of primary lung cancer and solitary brain metastasis. Thorax 1985; 40:191-193.

24) Milne ENC, Pistolesi M, Miniati M, Giuntini C: The radiologic distinction of cardiogenic and non cardiogenic edema. American Journal of Roentgenology 1985; 144:879-894.

25) Negrini D, Pistolesi M, Miniati M, Bellina CR, Giuntini C, Miserocchi G: Regional protein absorption rates from the pleural cavity in dogs. Journal of Applied Physiology 1985; 56:2062-2067.

26) Pistolesi M, Miniati M, Milne ENC, Giuntini C: The chest roentgenogram in pulmonary edema. Clinics in Chest Medicine 1985; 6:315-344.

27) Sarnelli R, Pistolesi M, Petruzzelli S, Miniati M, Santolicandro A, Giuntini C: Fatal peripheral airway cystic disease in a young woman. American Journal of Medicine 1986; 80:541-544.

28) Paoletti P, Fornai E, Pistolesi M, Giannella A, Marini C, Di Ricco G, Ruschi S, Prediletto R, Miniati M, Begliomini E, Giuntini C: Monitoring of gas exchange in severely ill patients. Progress in Respiration Research 1986; 21:207-210.

29) Pistolesi M, Miniati M, Di Ricco G, Marini C, Giuntini C: Perfusion lung imaging in the adult respiratory distress syndrome. Journal of Thoracic Imaging 1986; 1:11-24.

30) Miserocchi G, Negrini D, Fogliopara A, Pistolesi M, Miniati M, Bellina CR, Giuntini C: Kinetics of intrapleural distribution of a radioactive bolus. Respiration Physiology 1986; 65:13-27.

31) Pistolesi M, Milne ENC, Miniati M, Giuntini C: Detection and measurement of pulmonary edema: the chest radiographic approach. Intensive & Critical Care Digest 1986; 5:34-36.

32) Giuntini C, Pistolesi M, Miniati M, Fazio F: Extravascular lung water. European Journal of Nuclear Medicine 1987; 13:S63-S69.

33) Miniati M, Pistolesi M, Milne ENC, Giuntini C: Detection of lung edema. (Review Article). Critical Care Medicine 1987; 15:1146-1155.

34) Miniati M, Pistolesi M, Paoletti P, Giuntini C, Lebowitz MD, Taylor AE, Milne ENC: Objective radiographic criteria to differentiate cardiac, renal, and injury lung edema. Investigative Radiology 1988; 23:433-440.

35) Pistolesi M, Miniati M, Giuntini C: A radiographic score for clinical use in the adult respiratory distress syndrome. Intensive & Critical Care Digest 1988; 7:2-4.

36) Miserocchi G, Negrini D, Pistolesi M, Bellina CR, Gilardi MC, Bettinardi V, Rossitto F: Intrapleural liquid flow down a gravity-dependent hydraulic pressure gradient. Journal of Applied Physiology 1988; 64:577-584.

37) Pistolesi M, Miniati M, Bonsignore MR, Andreotti F, Di Ricco G, Marini C, Rindi M, Biagini A, Milne ENC, Giuntini C: Factors affecting regional pulmonary blood flow in chronic ischemic heart disease. Journal of Thoracic Imaging 1988; 3:65-72.

38) Pistolesi M, Miniati M, Giuntini C: Lung water measurement in intensive care units. (Letter to the Editor). American Review of Respiratory Disease 1988; 137:747-748.

39) Giuntini C, Pistolesi M, Miniati M, Fazio F: Theoretical and practical considerations of measuring extravascular lung water. Journal of Thoracic Imaging 1988; 3:36-43.

40) Miniati M, Parker JC, Pistolesi M, Cartledge JT, Martin D, Giuntini C, Taylor AE: Reabsorption kinetics of albumin from the pleural space of dogs. American Journal of Physiology 1988; 255:H375-H385.

41) Pistolesi M, Miniati M, Petruzzelli S, Carrozzi L, Giani L, Bellina CR, Gerundini P, Fazio F, Giuntini C: Pulmonary retention of iodobenzyl-propanediamine in humans. Effect of cigarette smoking. American Review of Respiratory Disease 1988; 138:1429-1433.

42) Pistolesi M, Miniati M, Milne ENC, Giuntini C: Measurement of pulmonary edema: the radiographic approach. Applied Cardiopulmonary Pathophysiology 1988; 2:141-150.

43) Pistolesi M, Miniati M, Bonsignore MR: Bedside measurement of extravascular lung water. In: Update in Intensive Care and Emergency Medicine, JL Vincent, ed., Berlin,  Germany, Springer-Verlag, 1989, pp. 65-71.

44) Giuntini C, Pistolesi M, Miniati M: Mechanisms and consequences of pulmonary venous hypertension. In: Pulmonary Circulation: Advances and Controversies, Wagenvoort CA, ed., New York, USA, Elsevier Science Publishers, 1989, pp. 131-147.

45) Pistolesi M, Miniati M, Bonsignore MR, Andreotti F, Di Ricco G, Marini C, Rindi M, Biagini A, Milne ENC, Giuntini C: Pulmonary circulation in patients with chronic left heart failure and pulmonary edema. In: Interaction between Heart and Lung, Daum S, ed., Stuttgart,  Germany, Georg Thieme Verlag, 1989, pp. 102-105.

46) Petruzzelli S, Palla A, Prediletto R, Mazzuca N, Pistolesi M, Giuntini C: SPECT perfusion imaging with 123I-HIPDM in a patient with pulmonary embolism. Journal of Nuclear Medicine and Allied Sciences 1989; 33:45-48.

47) Pistolesi M, Miniati M, Giuntini C: Pleural liquid and solute exchange. (State of the Art Review). American Review of Respiratory Disease 1989; 140:825-847.         

48) Paci A, Ciarimboli G, Miniati M, Cocci F, Piras F, Pistolesi M: Lung tissue binding of iodobenzyl-propanediamine: involvement of beta-adrenergic receptors. Journal of Pharmaceutical and Biomedical Analysis 1989; 7:1467-1472.

49) Pistolesi M, Miniati M, Milne ENC, Giuntini C: Pulmonary Edema. In: Radiologic Diagnosis of Chest Diseases, Sperber M, ed., New York, USA, Springer, 1990, pp. 355-373.  

50) Milne ENC, Pistolesi M: Pulmonary edema. Cardiac and non cardiac. In: Diagnostic Imaging of the Lung, Putman CE, ed., New York,  USA, Marcel Dekker, 1990, pp. 253-336.    

51) Pistolesi M, Miniati M, Monti S, Giuntini C, Milne ENC: Scientific use of the chest radiograph in intensive care unit. In: Intensive and Critical Care Medicine, Aochi O, Amaha K, Takeshita H, eds., Amsterdam,  Holland, Excerpta Medica, 1990, pp. 91-96.

52) Miniati M, Pistolesi M, Giani L, Paci A, Cocci F, Monti S, Giuntini C: Evaluation of nonrespiratory function of the human lung in health and disease by external detection of HIPDM. In: Endothelial and Mucus Secreting Cells, Junod AF, Olivieri D, Pozzi E, eds., Milano, Masson, 1991, pp 133-144.

53) Miniati M, Pistolesi M, Milne ENC, Giuntini C: Cardiogenic and non-cardiogenic oedema. In: Imaging of the Chest: An Update, Lissner J, ed., Berlin,  Germany, Springer Productions, 1991, pp. 133-139.

54) Balbarini A, Limbruno U, Bertoli D, Tartarini G, Baglini R, Mariotti R, Pistolesi M, Mariani M: Evaluation of pulmonary vascular pressures in cardiac patients: the role of the chest roentgenogram. Journal of Thoracic Imaging 1991; 6:62-68.

55) Pistolesi M, Miniati M, Milne ENC, Giuntini C:  Measurement of extravascular lung water.  Intensive Care World 1991;  8:16-21.

56) Bombino M, Gattinoni L, Pesenti A, Pistolesi M, Miniati M: The value of portable chest roentgenography in adult respiratory distress syndrome: comparison with computed tomography. Chest 1991; 100:762-769.

57) Miniati M, Pistolesi M, Monti S, Giuntini C: Nuclear medicine in ARDS: clinical applications. Applied Cardiopulmonary Pathophysiology 1991; 4:55-62.

58) Pistolesi M, Miniati M, Milne ENC, Giuntini C.  Radiologie de l'oedème pulmonaire.  In : Oedèmes pulmonaires, Lemaire F, Zelter M, eds., Paris,  France, Masson, 1992, pp. 113-124.

59) Miniati M, Cocci F, Paci A, Giani L, Pistolesi M: Evaluation of nonrespiratory function of the human lung by HIPDM lung scanning. Clinical Physiology 1992; 12:303-311.

60) Miniati M, Pistolesi M: Imaging strategies in the detection and evaluation of ARDS. Schweizerische Medizinische Wochenschrift 1993; 123:464-472.

61) Prediletto R, Formichi B, Allescia G, Paoletti P, Begliomini E, Fornai E, Pistolesi M, Giuntini C: The application of techniques for the assessment of respiratory function in a patient with dispnoea and severe hypoxemia. Monaldi Archives for Chest Disease 1993; 48:213-220.

62) Milne ENC, Pistolesi M: Radiology of Pulmonary Edema. In: Pulmonary Radiology, Potchen EJ, Grainger R, Greene R, eds., Philadelphia, USA, W.B. Saunders, 1993, pp. 113-124.

63) Pistolesi M, Miniati M, Milne ENC: Formation and Absorption of Pleural Liquid: Physiological and Pathophysiological Aspects and Radiologic Significance. In: Pulmonary Radiology, Potchen EJ, Grainger R, Greene R, eds., Philadelphia,  USA, W.B. Saunders, 1993, pp. 141-155.

64) Milne ENC, Pistolesi M: Reading the Chest Radiograph. A Physiologic Approach. St Louis, USA, Mosby, 1993. (383 pages with 623 illustrations).

Chapters: 1) Reading the chest radiograph. The value of adding a physiologic approach. - 2) Radiologic appearances of pulmonary edema. Anatomic and physiologic basis. - 3) Detection and quantification of pulmonary edema. - 4) Assessing systemic intra-and extravascular water. - 5) Pleural effusion. Normal physiology, pathophysiology, and diagnosis. - 6) Quantification of pulmonary blood volume, flow, and pressure. Principles. - 7) Quantification of pulmonary blood volume, flow, and pressure. Practice. - 8) Differentiating increased pressure from injury pulmonary edema. - 9) Detecting and quantifying chronic bronchitis and emphysema. - 10) Intensive care unit radiology. - 11) Compendium of pathophysiologic patterns.

65) Angeletti CA, Mussi A, Chella A, Janni A, Parenti G, Pistolesi M: Surgical treatment of non small- cell lung cancer and solitary brain metastasis. In: Lung cancer. Frontiers in Science and Treatment, Motta G, ed., Genova, Grafica L.P., 1994, pp. 549-556.

66) Hansson L, Wollmer P, Willen H, Jeppsson B, Pistolesi M: Pulmonary disposition of radioactive iodobenzyl-propanediamine in septic rats. Applied Cardiopulmonary Pathophysiology 1994;  5:111-115.

67) The PISA-PED Investigators ( in alphabetical order: Allescia G, Di Ricco G, Formichi B, Giuntini C, Marini C, Miniati M, Pistolesi M, Prediletto R, Sostman HD): Invasive and noninvasive diagnosis of pulmonary embolism. Chest 1995; 107:33S-38S.

68) Miniati M, Filippi E, Falaschi F, Carrozzi L, Milne ENC, Sostman HD, Pistolesi M: Radiologic evaluation of emphysema in patients with COPD. Chest radiography versus high resolution computed tomography. American Journal of Respiratory and Critical Care Medicine 1995; 151:1359-1367.

69) Miniati M, Cocci F, Monti S, Filippi E, Sarnelli R, Ferdeghini M, Gattai V, Pistolesi M: Lazaroid U-7439F attenuates phorbol-ester-induced lung injury in rabbits. European Respiratory Journal 1996; 9:758-764.

70) Miniati M, Pistolesi M, Marini C, Di Ricco G, Formichi B, Prediletto R, Allescia G, Tonelli L, Sostman HD, Giuntini C (The PISA-PED Investigators): Value of perfusion lung scan in the diagnosis of pulmonary embolism. Results of the Prospective Investigative Study of Acute Pulmonary Embolism Diagnosis (PISA-PED). American Journal of Respiratory and Critical Care Medicine 1996; 154:1387-1393.

71) Miniati M, Paci A, Cocci F, Ciarimboli G, Monti S, Pistolesi M: Mitochondria act as reservoir for the basic amine HIPDM in the lung. European Respiratory Journal 9:2306-2312, 1996.

72) Mussi A, Pistolesi M, Lucchi M, Janni A, Chella A, Parenti G, Rossi G, Angeletti CA: Resection of single brain metastasis in non-small-cell lung cancer: prognostic factors. Journal of Thoracic and Cardiovascular Surgery 1996; 112:146-153.

73) Miniati M, Marini C, Allescia G, Tonelli L, Formichi B, Prediletto R, Di Ricco G, Bauleo C, Pistolesi M. Non-invasive diagnosis of pulmonary embolism. International Journal of Cardiology 1998; 65 (Suppl 1):S83-S86.

74) Pistolesi M, Milne ENC. Radiology of Cardio-Pulmonary Hemodynamic Disturbances. In: 1999 Edition of Taveras and Ferrucci's "Radiology: Diagnosis, Imaging, Intervention", Philadelphia, USA, Lippincott Williams & Wilkins, 1999 (chapter 71- CD edition).

75) Prediletto R, Miniati M, Tonelli L, Formichi B, Di Ricco G, Marini C, Bauleo C, Allescia G, Cocci F, Monti S, Pistolesi M, Giuntini C. Diagnostic value of gas exchange tests in patients with clinical suspicion of pulmonary embolism. Critical Care 1999; 3:111-116.

76) Fontana GA, Pantaleo T, Lavorini F, Maluccio NM, Mutolo D, Pistolesi M. Repeatability of cough-related variables during fog challenges at threshold and suprathreshold stimulus intensity in humans. European Respiratory Journal 1999; 13:1447-1450.

77) Camiciottoli G, Trapani S, Ermini M, Falcini F, Pistolesi M. Pulmonary function in children affected by juvenile spondyloarthropathy. Journal of Rheumatology 1999; 26:1382-1386.

78) Fontana GA, Lavorini F, Chiostri M, Castellani W, Boddi V, Pistolesi M. Large and small airway responses to procaterol hydrochloride administered through different extension devices in asthmatic patients. Journal of Aerosol Medicine 1999; 12:177-185.

79) Pistolesi M. Pulmonary embolism: opinions and facts (editorial comment). Cardiologia 1999; 44:743-745.

80) Miniati M, Prediletto R, Formichi B, Marini C, Di Ricco G, Tonelli L, Allescia G, Pistolesi M. Accuracy of clinical assessment in the diagnosis of pulmonary embolism. American Journal of Respiratory and Critical Care Medicine 1999; 159:864-871.

81) Fontana GA, Pantaleo T, Lavorini F, Polli G, Pistolesi M. Coughing in laryngectomized patients. American Journal of Respiratory and Critical Care Medicine 1999; 160:1578-1584.

82) Pistolesi M, Lavorini F, Fontana G, Mascalchi M, Milne ENC. Pulmonary Edema. In: Radiologic Diagnosis of Chest Disease (2^nd  Edition), Sperber M, ed., London, UK, Springer Verlag Publisher London, 2000 (chapter 25, pp. 347-367).

83) Lavorini F, Fontana GA, Pantaleo T, Camiciottoli G, Castellani W, Maluccio NM, and Pistolesi M. Fog-induced respiratory responses are attenuated by nedocromil sodium in humans. American Journal of Respiratory and Critical Care Medicine 2001; 163:1117-1120.

84) Trapani S, Camiciottoli G, Vierucci A, Pistolesi M, Falcini F. Pulmonary involvement in juvenile dermatomyositis: a two year longitudinal study. Rheumatology 2001; 40:216-220.

85) Miniati M, Monti S, Pratali L, Di Ricco G, Marini C, Formichi B, Prediletto R, Michelassi C, Di Lorenzo M, Tonelli L, Pistolesi M. Value of thansthoracic echocardiography in the diagnosis of pulmonary embolism: results of a prospective study in unselected patients. American Journal of Medicine 2001; 110:528-535.

86) Pistolesi M, Pupi A. Pulmonary embolism diagnosis. What role for nuclear medicine? Quarterly Journal of Nuclear Medicine 2001; 45:277-280.

87) Miniati M, Pistolesi M. Assessing the clinical probability of pulmonary embolism. Quarterly Journal of Nuclear Medicine 2001; 45:287-293, 2001.

88) Pistolesi M, Miniati M. Imaging techniques in treatment algorithms of pulmonary embolism. European Respiratory Journal 2002; 19(Suppl 35):28s-39s.

89) Romano MS, Pistolesi M. Assessment of cardiac output from systemic arterial pressure in humans. Critical Care Medicine 2002; 30:1834-1841.

90) Fontana GA, Pantaleo T, Lavorini F, Bongianni F, Mannelli M, Bridge PD, Pistolesi M. Handgrip induced airway dilation in asthmatic patients with bronchocostriction induced by Mch inhalation. Journal of Applied Physiology 2002; 93:1723-1730.

91) Fontana GA, Lavorini F, Pistolesi M. Water aerosols and cough. Pulmonary Pharmacology and Therapeutics 2002; 15:205-211.

92) Romano SM, Lazzeri C, Chiostri M, Toso A, Foschi M, Pistolesi M, Di Donato M, Franchi F. Continuous recording of dicrotic and pulse pressures during head-up tilting test: the vasodepressive profile. Preliminary data. Italian Heart Journal 2002; 3:665-672.

93) Franchi F, Lazzeri C, Romano SM, Toso A, Chiostri M, Foschi M, Pistolesi M, Di Donato M. Baroreflex function in vasodepressive syncope: detection of early impairment. Medical Science Monitor 2003;  9:125-130.

94) Moroni C, Mascalchi M, Camiciottoli G, Bartolucci M, Falaschi F, Battolla L, Orlandi I, Pistolesi M, Villari N. Comparison of spirometric-gated and -ungated HRCT in COPD. Journal of Computer Assisted Tomography 2003; 27: 375-379.

95) Fontana GA, Pistolesi M. Chronic cough and gastro-oesophageal reflux. Thorax 2003; 58:1092-1095.

96) Lavorini F, Geri P, Luperini M, Maluccio NM, Mariani L, Marmai C, Pistolesi M, Fontana GA. Clinical and functional responses to salbutamol inhaled via different devices in asthmatic patients with induced bronchoconstriction. British Journal of  Clinical  Pharmacology 2004; 58:512-520.

  97) Pistolesi M, Lavorini F, Allescia G, Miniati M. Diagnostic strategies for suspected pulmonary    embolism. European Respiratory Monograph 2004; 30:89-105.

98) Pistolesi M, Rusthoven J. Malignant pleural mesothelioma: update, current management, and  newer therapeutic options. Chest 2004; 126:1318-1329.

   99) Morice AH, Fontana GA, Sovijarvi AR, Pistolesi M, Chung KF, Widdicombe J, O'Connell F,  Geppetti P, Gronke L, De Jongste J, Belvisi M, Dicpinigaitis P, Fischer A, McGarvey L, Fokkens WJ, Kastelik J; ERS Task Force. The diagnosis and management of chronic cough. European Respiratory Journal 2004; 24:481-492.

100) O'Byrne PM, Bisgaard H, Godard PP, Pistolesi M, Palmqvist M, Zhu Y, Ekstrom T, Bateman  ED. Budesonide/Formoterol combination therapy as both maintenance and reliever medication in asthma. American Journal of Respiratory and Critical Care Medicine 2005; 171:129-136.

101) Orlandi I, Moroni C, Camiciottoli G, Bartolucci M, Pistolesi M, Villari N, Mascalchi A. Chronic obstructive pulmonary disease: thin-section CT measurement of airway wall thickness and lung attenuation. Radiology 2005; 234:604-610.   

102) Camiciottoli G, Bartolucci M, Maluccio NM, Moroni C, Mascalchi M, Giuntini G, Pistolesi M. Spirometrically-gated high-resolution CT findings in COPD: lung attenuation versus lung function and dyspnea severity. Chest 2006; 129:558-64.

103) Lavorini F, Geri P, Mariani L, Marmai C, Maluccio NM, Pistolesi M, Fontana GA. Speed of onset of bronchodilator response to salbutamol inhaled via different devices in asthmatics: a bioassay based on functional antagonism.British Journal of Clininical Pharmacology 2006; 62:403-11.

104) Lavorini F, Pantaleo T, Geri P, Mutolo D, Pistolesi M, Fontana GA. Cough and ventilatory  adjustments evoked by aerosolised capsaicin and distilled water (fog) in man. Respiration Physiology and Neurobiology 2007;156:331-9.

105) Luciani D, Cavuto S, Antiga L, Miniati M, Monti S, Pistolesi M, Bertolini G. Bayes pulmonary embolism assisted diagnosis: a new expert system for clinical use. Emergency Medicine Journal 2007; 24:157-64.

106) Camiciottoli G, Orlandi I, Bartolucci M, Meoni E, Nacci F, Diciotti S, Barcaroli C, Conforti ML, Pistolesi M, Matucci-Cerinic M, Mascalchi M. Lung CT densitometry in systemic sclerosis: correlation with lung function, exercise testing, and quality of life. Chest 2007; 131:672-81.

107) Lavorini F, Fontana GA, Pantaleo T, Geri P, Piumelli R, Pistolesi M, Widdicombe J. Fog-induced cough with impaired respiratory sensation in congenital central hypoventilation syndrome. American Journal of Respiratory and Critical Care Medicine 2007; 176:825-32.

108) Giuntini C, Camiciottoli G, Maluccio NM, Mariani L, Lavorini F, Pistolesi M. Chronic effort dyspnea explained by lung function tests and by HRCT and CRX radiographic patterns in COPD: a post-hoc analysis in 51 patients.COPD. Journal of Chronic Obstructive Pulmonary Disease 2007;4:169-76.

109) Remy-Jardin M, Pistolesi M, Goodman LR, Gefter WB, Gottschalk A, Mayo JR, Sostman HD. Management of suspected acute pulmonary embolism in the era of CT angiography: a statement from the Fleischner Society. Radiology 2007; 245:315-29.

110) Lavorini F, Geri P, Camiciottoli G, Pistolesi M, Fontana GA. Agreement between two methods for assessing bioequivalence of inhaled salbutamol. Pulmonary Pharmacology and Therapeutics 2008; 21:380-4.

111) Cazzola M, MacNee W, Martinez FJ, Rabe KF, Franciosi LG, Barnes PJ, Brusasco V, Burge PS, Calverley PM, Celli BR, Jones PW, Mahler DA, Make B, Miravitlles M, Page CP, Palange P, Parr D, Pistolesi M, Rennard SI, Rutten-van Mölken MP, Stockley R, Sullivan SD, Wedzicha JA, Wouters EF; American Thoracic Society; European Respiratory Society Task Force on outcomes of COPD.Outcomes for COPD pharmacological trials: from lung function to biomarkers. European Respiratory Journal 2008; 31:416-69.

112) Pistolesi M, Camiciottoli G, Paoletti M, Marmai C, Lavorini F, Meoni E, Marchesi C, Giuntini C. Identification of a predominant COPD phenotype in clinical practice. Respiratory Medicine. 2008; 102:367-76.

113) Stein PD, Sostman HD, Bounameaux H, Buller HR, Chenevert TL, Dalen JE, Goodman LR, Gottschalk A, Hull RD, Leeper KV Jr, Pistolesi M, Raskob GE, Wells PS, Woodard PK.Challenges in the diagnosis of acute pulmonary embolism. American Journal of Medicine 2008; 121:565-71.

115) Sostman HD, Miniati M, Gottschalk A, Matta F, Stein PD, Pistolesi M. Sensitivity and Specificity of Perfusion Scintigraphy Combined with Chest Radiography for Acute Pulmonary Embolism in PIOPED II. Journal of Nuclear Medicine 2008;49:1741-1748.

116) Miniati M, Sostman HD, Gottschalk A, Monti S, Pistolesi M. Perfusion Lung Scintigraphy for the

Diagnosis of Pulmonary Embolism: A Reappraisal and Review of the Prospective Investigative Study of Acute Pulmonary Embolism Diagnosis Methods. Seminars in Nuclear Medicine 2008; 38:450-461.

117) Damjanov N, Ostojic P, Kaloudi O, Alari S, Guiducci S, Stanflin N, Nestorovic B, Knezevic J, Camiciottoli G, Porta F, Pistolesi M, Ibba-Manneschi L, Conforti ML, Candelieri A, Matucci Cerinic M. Induced Sputum in Systemic Sclerosis Interstitial Lung Disease: Comparison to Healthy Controls and Bronchoalveolar Lavage. Respiration 2009;78:56-62.

118) Cavigli E, Camiciottoli G, Diciotti S, Orlandi I, Spinelli C, Meoni E, Grassi L, Farfalla C, Pistolesi M, Falaschi F, Mascalchi M. Whole-lung densitometry versus visual assessment of emphysema. European  Radiology 2009;19:1686-1692.

119) Lucignani G, Pistolesi M. Diagnosing pulmonary embolism: clinical problem or methodological issue? European Journal of Nuclear Medicine and Molecular Imaging. 2009;36:522-528.

120) Pistolesi M. Beyond airflow limitation: another look at COPD. Thorax. 2009;64:2-4.

121) Paoletti M, Camiciottoli G, Meoni E, Bigazzi F, Cestelli L, Pistolesi M, Marchesi C. Explorative data analysis techniques and unsupervised clustering methods to support clinical assessment of Chronic Obstructive Pulmonary Disease (COPD) phenotypes. Journal of Biomedical Informatics. 2009;42:1013-1021.

122) Pistolesi M. Pulmonary CT angiography in patients suspected of having pulmonary embolism: case finding or screening procedure? Radiology 2010; 256:334-337.

123) Lavorini F, Fontana GA, Chellini E, Magni C, Pistolesi M, Widdicombe J. Respiratory Expulsive Efforts Evoked by Maximal Lung Emptying. Chest 2011;140:690-696.

124) Lavorini F, Fontana G, Chellini E, Magni C, Pistolesi M, Widdicombe J. The fontana paradoxical reflex? Chest 2011;140:586-88.

125) Stein PD, Sostman HD, Dalen JE, Bailey DL, Bajc M, Goldhaber SZ, Goodman LR, Gottschalk A, Hull RD, Matta F, Pistolesi M, Tapson VF, Weg JG, Wells PS, Woodard PK; Consensus Group. Controversies in diagnosis of pulmonary embolism. Clinical Applied Thrombosis and Hemostasis 2011;17:140-9.

126) Sostman HD, Pistolesi M. Scintigraphy for Pulmonary Embolism: Too Old to Rock 'n' Roll, Too Young to Die? Journal of  Nuclear Medicine 2011;52:1505-57.

127) Rowan C, Hansell DM, Renzoni E, Maher TM, Wells AU, Polkey MI, Rehal PK, Ibrahim WH, Kwong GN, Colby TV, Pistolesi M, Bigazzi F, Comin CE, Nicholson AG. Diffuse cystic lung disease of unexplained cause with coexistent small airway disease: a possible causal relationship? American Journal of Surgical Patholology 2012;36:228-234.

128) Palla A, Rossi G, Falaschi F, Marconi L, Pistolesi M, Prandoni P. Is incidentally detected pulmonary embolism in cancer patients less severe? A case-control Study. Cancer Investigation 2012; 30:131-134.

129)  Camiciottoli G, Bigazzi F, Bartolucci M, Cestelli L, Paoletti M, Diciotti S, Cavigli E, Magni C, Buonasera L, Mascalchi M, Pistolesi M. BODE-index, modified BODE-index and ADO-score in Chronic Obstructive Pulmonary Disease: relationship with COPD phenotypes and CT lung density changes. COPD 2012;297-304.

130) Barr CC, Berkowitz EA, Bigazzi F, Bode F, Bon J, Bowler RP, Chiles C, Crapo JD, Criner GJ, Curtis JL, Dass C, Dirksen A, Dransfield MT, Edula G, Erikkson L, Friedlander A, Galperin-Aizenberg M, Gefter WB, Gierada DS, Grenier PA, Goldin J, Han MK, Hanania NA, Hansel NN, Jacobson FL, Kauczor HU, Kinnula VL, Lipson DA, Lynch DA, Macnee W, Make BJ, Mamary AJ, Mann H, Marchetti N, Mascalchi M, McLennan G, Murphy JR, Naidich D, Nath H, Newell JD Jr, Pistolesi M, Regan EA, Reilly JJ, Sandhaus R, Schroeder JD, Sciurba F, Shaker S, Sharafkhaneh A, Silverman EK, Steiner RM, Strange C, Sverzellati N, Tashjian JH, Beek EJ, Washington L, Washko GR, Westney G, Wood SA, Woodruff PG. A Combined Pulmonary-Radiology Workshop for Visual Evaluation of COPD: Study Design, Chest CT Findings and Concordance with Quantitative Evaluation.COPD 2012;9:151-159.

131) Polverino F, Ricciardi M, Polverino M, Santoriello C, Palladino R, Pistolesi M. Voice box symptoms: a hitherto unknown presentation of pulmonary embolism. American Journal of Respiratory and Critical Medicine 2013;187:108-110.

132) Cerveri I, Corsico AG, Grosso A, Albicini F, Ronzoni V, Tripon B, Imberti F, Galasso T, Klersy C, Luisetti M, Pistolesi M. The Rapid FEV(1) Decline in chronic obstructive pulmonary disease is associated with predominant emphysema: a longitudinal study. COPD 2013;10:55-61.

133) Naidich DP, Bankier AA, MacMahon H, Schaefer-Prokop CM, Pistolesi M, Goo JM, Macchiarini P, Crapo JD, Herold CJ, Austin JH, Travis WD. Recommendations for the management of subsolid pulmonary nodules detected at CT: a statement from the Fleischner Society. Radiology 2013;266:304-317.

134) Camiciottoli G, Bigazzi F, Paoletti M, Cestelli L, Lavorini F, Pistolesi M. Pulmonary function and sputum characteristics predict CT phenotype and severity of COPD. European Respiratory Journal 2013, in press.

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