Elisa GIANNONI

Ruolo attuale:: Professore Ordinario
SSD:: BIOS-07/A - Biochimica
Afferenza organizzativa:: Dipartimento di Scienze Biomediche, Sperimentali e Cliniche 'Mario Serio'

Recapiti

	0552751236
	elisa.giannoni(AT)unifi.it

Elisa GIANNONI

Orario di ricevimento (aggiornato al 04/05/2017)

Giorni e orari vengono fissati accordandosi direttamente con il docente

Elisa GIANNONI

Biografia

1) Magherini F., Giannoni E., Raugei G., Cirri P., Paoli P., Modesti A., Camici G., Ramponi G. “Cloning of murine low molecular weight phosphotyrosine protein phosphatase cDNA: identification of a new isoform”, FEBS Letters (1998), 437: 263-266. IF: 3.864

2) Chiti F., Taddei N., Giannoni E., van Nuland N.A.J., Ramponi G., Dobson C.M. “Development of enzymatic activity during protein folding. Detection of a spectroscopically silent native-like intermediate of muscle acylphosphatase.” J. Biol. Chem. (1999), 274: 20151-20158. IF: 5.485

3) Chiarugi P., Cirri P., Taddei L., Giannoni E., Camici G., Manao G., Raugei G., Ramponi G. “The low M(r) protein-tyrosine phosphatase is involved in Rho-mediated cytoskeleton rearrangement after integrin and platelet-derived growth factor stimulation” J. Biol. Chem. (2000), 275(7): 4640-6. IF: 5.485

4) Paoli P., Camici G., Manao G., Giannoni E., Ramponi G. “Acylphosphatase possesses nucleoside triphosphatase and nucleotide diphosphatase activities”, Biochem. J. (2000), 349 (Pt 1): 43-49. IF: 3.766

5) Giannoni E., Cirri P., Paoli P., Fiaschi T., Camici G., Manao G., Raugei G., Ramponi G. “Acylphosphatase is a strong apoptosis inducer in HeLa cell line”, Mol. Cell. Biol. Res. Commun. (2000), 3(5): 264-70.IF: ND

6) Chiarugi P., Fiaschi T., Taddei M.L., Talini D. Giannoni E., Raugei G., Ramponi G. “Two vicinal cysteines confer a peculiar redox regulation to low molecular weight protein tyrosine phosphatase in response to platelet-derived growth factor receptor stimulation.” J. Biol. Chem.(2001), 276(36): 33478-87. IF: 5.485

7) Paoli P., Giannoni E., Pescitelli R., Camici G., Manao G., Ramponi G. “Hydrogen peroxide triggers the formation of a disulfide dimer of muscle acylphosphatase and modifies some functional properties of the enzyme.” J. Biol. Chem. (2001) 276(45): 41862-9. IF: 5.485

8) Fiaschi T., Chiarugi P., Buricchi F., Giannoni E., Taddei M.L., Talini D., Cozzi G., Zecchi-Orlandini S., Raugei G., Ramponi G. “LMW-PTP is involved in growth inhibition during cell differentiation” J. Biol. Chem. (2001), 276(52): 49156-63. IF: 5.485

9) Bucciantini M.*, Giannoni E.*, Chiti F., Baroni F., Formigli L., Zurdo J., Taddei N., Dobson C.M., Stefani M. “Inherent toxicity of polypeptide aggregates suggests a common origin of protein misfolding disease” Nature (2002), 416(6880): 507-11. IF: 69.504

10) Chiarugi P., Cirri P., Taddei M.L., Talini D., Doria L., Fiaschi T., Buricchi F., Giannoni E., Camici G., Raugei G., Ramponi G. “New perspectives in PDGF receptor downregulation: the main role of phosphotyrosine phosphatases” J. Cell. Sci. (2002), 115(Pt 10): 2219-32. IF: 5.235

11) Chiarugi P., Cirri P., Taddei M.L., Giannoni E., Fiaschi T., Buricchi F., Camici G., Raugei G., Ramponi G. “Insight into the role of low molecular weight phosphotyrosine phosphatase (LMW-PTP) on platelet-derived growth factor receptor (PDGF-r) signaling. LMW-PTP controls PDGF-r kinase activity through TYR-857 dephosphorylation” J. Biol. Chem. 2002 Oct 4;277(40):37331-8 IF: 5.485

12) Taddei M.L., Chiarugi P., Cirri P., Buricchi F., Fiaschi T., Giannoni E., Talini D., Cozzi G., Formigli L., Raugei G., Ramponi G. “Beta-catenin interacts with Low-Molecular-Weight Protein Tyrosine Phosphatase leading to cadherin-mediated cell-cell adhesion increase” Cancer Res 2002 Nov 15;62(22):6489-99. IF: 13.312

13) Paoli P., Pazzagli L., Giannoni E., Caselli A., Manao G., Camici G., Ramponi G. “A Nucleophilic Catalysis Step is Involved in the Hydrolysis of Aryl Phosphate Monoesters by Human CT Acylphosphatase.” J. Biol. Chem. 2003 Jan 3; 278(1): 194-9 IF: 5.485

14) Iantomasi T., Favilli F., Catarzi S., Giannoni E., Biagioni C., Vincenzini MT. “Involvement of the tyrosine phosphorylation on GSH transport in NIH3T3 fibroblasts.” IUBMB Life. 2003 Mar;55(3):159-65. IF: 4.709

15) Chiarugi P., Pani G., GiannoniE., Taddei M.L., Colavitti R., Raugei G., Symons M., Borrello S., Galeotti T., Ramponi G. “Reactive oxygen species as essential mediators of cell

adhesion: the oxidative inhibition of a FAK tyrosine phosphatase is required for cell adhesion” J. Cell. Biol. 2003 Jun 9;161(5):933-44 IF: 8.077

16) Giannoni E., Chiarugi P., Cozzi G., Magnelli L., Taddei M. L., Fiaschi T., Buricchi F., Raugei G., Ramponi G. “LFA-1 mediated T cell adhesion is impaired by Low Molecular Weight phosphotyrosine phosphatase-dependent inhibition of FAK activity” J. Biol. Chem. 2003 Sep 19;278(38):36763-76. IF: 5.485

17) Fiaschi T., Chiarugi P., Buricchi F., Giannoni E., Taddei M. L., Magnelli L., Cozzi G., Raugei G., Ramponi G. “Down-regulation of PDGF receptor signaling during myogenesis.” Cell. Mol. Life. Sc. 2003 Dec;60(12):2721-35 IF: 9.234

18) Chiarugi P., Taddei M. L., Schiavone N., Papucci L., Giannoni E., Capaccioli S., Raugei G., Ramponi G. “LMW-PTP is a positive regulator of tumor onset and growth” Oncogene 2004 May 13;23(22):3905-14. IF: 8.756

19) Ventura S., Zurdo J., Narayanan S., Parreno M., Mangues R., Reif B., Chiti F., Giannoni E., Dobson C.M., Aviles F.X., Serrano L. “Short amino acid stretches can mediate amyloid formation in globular proteins: the Src homology 3 (SH3) case.”Proc Natl Acad Sci U S A. 2004 May 11;101(19):7258-63 IF: 12.779

20) Cecchi C., Liguri G., Fiorillo C., Bogani F., Gambassi M., Giannoni E., Cirri P., Baglioni S., Ramponi G. “Acylphosphatase overexpression triggers SH-SY5Y differentiation towards neuronal phenotype.” Cell. Mol. Life Sci. 2004 Jul;61(14):1775-84. IF: 9.234

21)Cirri P., Taddei M.L., Chiarugi P., Buricchi F., Caselli A., Paoli P., Giannoni E., Camici G., Manao G., Raugei G., Ramponi G. “Insulin inhibits PDGF-induced cell proliferation” Mol Biol Cell. 2005 Jan;16(1):73-83. IF: 3.612

22) Chiarugi P. and Giannoni E. “Anchorage-dependent cell growth: tyrosine kinases and phosphatases meet redox regulation” Antioxid Redox Signal. 2005 May-Jun;7(5-6):578-92. IF: 7.468

23) Giannoni E., Buricchi F., Raugei G., Ramponi G., Chiarugi P. “Intracellular Reactive Oxygen Species Activate Src Tyrosine Kinase during Cell Adhesion and Anchorage-Dependent Cell Growth.” Mol Cell Biol. 2005 Aug;25(15):6391-403. IF: 5.094

24) Parri M, Buricchi F, Taddei ML, Giannoni E, Raugei G, Ramponi G, Chiarugi P. " EphrinA1 repulsive response is regulated by an EphA2 tyrosine phosphatase." J. Biol. Chem. 2005 Oct 7;280(40):34008-18. IF: 5.485

25) Catarzi S, Biagioni C, Giannoni E, Favilli F, Marcucci T, Iantomasi T, Vincenzini MT. "Redox regulation of platelet-derived-growth-factor-receptor: role of NADPH-oxidase and c-Src tyrosine kinase." Biochim Biophys Acta. - Molecular Cell Research 2005 Sep 10;1745(2):166-75. IF: 5.011

26) Buricchi F, Chiarugi P, Fiaschi T, Giannoni E, Magnelli L, Fanti E, Raugei G, Ramponi G. "During muscle ageing the activation of the mitogenic signalling is not sufficient to guarantee cellular duplication." Ital J Biochem. 2005 Sep-Dec;54(3-4):258-67. IF: ND

27) Giannoni E, Raugei G, Chiarugi P, Ramponi G. "A novel redox-based switch: LMW-PTP oxidation enhances Grb2 binding and leads to ERK activation." Biochem Biophys Res Commun. 2006 Sep 22;348(2):367-73. IF: 3.322

28) Catarzi S, Giannoni E, Favilli F, Meacci E, Iantomasi T, Vincenzini MT. "Sphingosine 1-phosphate stimulation of NADPH oxidase activity: Relationship with platelet-derived growth factor receptor and c-Src kinase." Biochim Biophys Acta. - General Subjects 2007 Jun;1770(6):872-83. IF: 4.117

29) Parri M, Buricchi F, Giannoni E, Grimaldi G, Mello T, Raugei G, Ramponi G, Chiarugi P. "Ephrin-A1 activates a SRC/FAK-mediated motility response leading to RHO-dependent ACTINO/MYOSIN contractility." J. Biol. Chem. 2007 Apr 22 IF: 5.485

30) Buricchi F, Giannoni E., Grimaldi G., Parri M., Raugei G, Ramponi G, Chiarugi P. " Redox regulation of Ephrin/Integrin cross-talk" Cell Adhesion & Migration 1:1, 33-42; January/February/March 2007 IF: 3.255

31) Giannoni E, Buricchi F, Grimaldi G, Parri M, Cialdai F, Taddei ML, Raugei G, Ramponi G, Chiarugi P.“Redox regulation of anoikis: reactive oxygen species as essential mediators of cell survival.” Cell Death Differ. 2008 May;15(5):867-78. IF: 12.073

32)Chiarugi P. Giannoni E. “Anoikis: a necessary death program for anchorage-dependent cells.” Biochem Pharmacol. 2008 Dec 1;76(11):1352-64. IF: 6.100

33) Taddei ML, Parri M, Angelucci A, Onnis B, Bianchini F, Giannoni E, Raugei G, Calorini L, Rucci N, Teti A, Bologna M, Chiarugi P. "Kinase-dependent and -independent roles of EphA2 in the regulation of prostate cancer invasion and metastasis.” Am J Pathol. 2009 Apr;174(4):1492-503. IF: 5.770

34) Giannoni E, Fiaschi T, Ramponi G, Chiarugi P. “Redox regulation of anoikis resistance of metastatic prostate cancer cells: key role for Src and EGFR-mediated pro-survival signals.” Oncogene. 2009 May 21;28(20):2074-86. IF: 8.756

35) Pani G, Giannoni E, Galeotti T, Chiarugi P. “Redox-based escape mechanism from death: the cancer lesson.” Antioxid Redox Signal. 2009 Nov;11(11):2791-806. IF: 7.468

36) Fiaschi T, Tedesco FS, Giannoni E, Diaz-Manera J, Parri M, Cossu G, Chiarugi P. “Globular adiponectin as a complete mesangioblast regulator: role in proliferation, survival, motility and skeletal muscle differentiation.” Mol Biol Cell. 2010 Mar;21(6):848-59. IF: 3.612

37) Giannoni E, Taddei ML, Chiarugi P. “Src redox regulation: again in the front line.” Free Radic Biol Med. 2010 Aug 15;49(4):516-27. IF: 8.101

38) Giannoni E, Bianchini F, Masieri L, Serni S, Torre E, Calorini L, Chiarugi P. “Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness.” Cancer Res. 2010 Sep 1;70(17):6945-56. IF: 13.312

39) Taddei ML, Parri M, Angelucci A, Bianchini F, Marconi C, Giannoni E, Raugei G, Bologna M, Calorini L, Chiarugi P. “EphA2 induces metastatic growth regulating amoeboid motility and clonogenic potential in prostate carcinoma cells.” Mol Cancer Res. 2011 Feb;9(2):149-60. IF: 6.333

40) Giannoni E, Bianchini F, Calorini L, Chiarugi P. “Cancer associated fibroblasts exploit reactive oxygen species through a proinflammatory signature leading to epithelial mesenchymal transition and stemness.” Antioxid Redox Signal. 2011 Jun 15;14(12):2361-71. IF: 7.468

41) Comito G, Calvani M, Giannoni E, Bianchini F, Calorini L, Torre E, Migliore C, Giordano S, Chiarugi P. “HIF-1α stabilization by mitochondrial ROS promotes Met-dependent invasive growth and vasculogenic mimicry in melanoma cells.” Free Radic Biol Med. 2011 Aug 15;51(4):893-904. IF: 8.101

42) Taddei ML, Giannoni E, Fiaschi T, Chiarugi P. “Anoikis: an emerging hallmark in health and diseases. J Pathol. 2012 Jan;226(2):380-93. IF: 9.883

43) Giannoni E, Parri M, Chiarugi P. “EMT and Oxidative Stress: A Bidirectional Interplay Affecting Tumor Malignancy.” Antioxid Redox Signal. 2012 Jun 1;16(11):1248-63. IF: 7.468

44) Taddei ML, Giannoni E, Raugei G, Scacco S, Sardanelli AM, Papa S, Chiarugi P. “Mitochondrial Oxidative Stress due to Complex I Dysfunction Promotes Fibroblast Activation and Melanoma Cell Invasiveness.” J Signal Transduct. 2012;2012:684592. IF 2016: 2.2

45) Bianchini F, Giannoni E, Serni S, Chiarugi P, Calorini L. “22:6n-3 DHA inhibits differentiation of prostate fibroblasts into myofibroblasts and tumorigenesis.” Br J Nutr. 2012 Mar 6:1-9. IF: 4.125

46) Fiaschi T, Giannoni E, Taddei ML, Chiarugi P. “Globular adiponectin activates motility and regenerative traits of muscle satellite cells.” PLoS One. 2012;7(5):e34782. IF: 3.752

47) Comito G, Giannoni E, Di Gennaro P, Segura CP, Gerlini G, Chiarugi P. “Stromal fibroblasts synergize with hypoxic oxidative stress to enhance melanoma aggressiveness.” Cancer Lett. 2012 Nov 1;324(1):31-41. IF: 9.756

48) Fiaschi T, Marini A, Giannoni E, Taddei ML, Gandellini P, De Donatis A, Lanciotti M, Serni S, Cirri P, Chiarugi P. “Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay.” Cancer Res. 2012 Oct 1;72(19):5130-40. IF: 13.312

49) Giannoni E, Taddei ML, Parri M, Bianchini F, Santosuosso M, Grifantini R, Fibbi G, Mazzanti B, Calorini L, Chiarugi P. “EphA2-mediated mesenchymal-amoeboid transition induced by endothelial progenitor cells enhances metastatic spread due to cancer-associated fibroblasts.” J Mol Med (Berl). 2013 Jan;91(1):103-15. IF: 5.606

50) Pitozzi V, Mocali A, Laurenzana A, Giannoni E, Cifola I, Battaglia C, Chiarugi P, Dolara P, Giovannelli L. “Chronic Resveratrol Treatment Ameliorates Cell Adhesion and Mitigates the Inflammatory Phenotype in Senescent Human Fibroblasts.” J Gerontol A Biol Sci Med Sci. 2012 Aug 29. IF: 6.591

51) Serratì S, Chillà A, Laurenzana A, Margheri F, Giannoni E, Magnelli L, Chiarugi P, Dotor J, Feijoo E, Bazzichi L, Bombardieri S, Kahaleh B, Fibbi G, Del Rosso M. “Systemic sclerosis endothelial cells recruit and activate dermal fibroblasts by induction of a connective tissue growth factor (CCN2)/transforming growth factor β-dependent mesenchymal-to-mesenchymal transition.” Arthritis Rheum. 2013 Jan;65(1):258-69. IF: 15.483

52) Calvani M, Comito G, Giannoni E, Chiarugi P. “Time-dependent stabilization of hypoxia inducible factor-1α by different intracellular sources of reactive oxygen species.” PLoS One. 2012;7(10):e38388. IF: 3.752

53) Taddei ML, Giannoni E, Comito G, Chiarugi P. “Microenvironment and tumor cell plasticity: An easy way out.” Cancer Lett. 2013 Nov 28;341(1):80-96. IF: 9.756

54) Fiaschi T, Giannoni E, Taddei ML, Cirri P, Marini A, Pintus G, Nativi C, Richichi B, Scozzafava A, Carta F, Torre E, Supuran CT, Chiarugi P. “Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells”. Cell Cycle. 2013 May 8;12(11). IF: 5.173

55) Comito G, Giannoni E, Pons Segura C, Barcellos-de-Souza P, Raspollini MR, Baroni G, Lanciotti M, Serni S and Chiarugi P “Cancer associated fibroblasts and M2 polarized macrophages synergize during prostate carcinoma progression” Oncogene. 2014 May 8;33(19):2423-31. IF: 8.756

56) Gandellini P*, Giannoni E*, Casamichele A, TaddeiML, Callari C, Valdagni R, Pierotti MA, Zaffaroni N and Chiarugi P “miR-205 hinders the malignant interplay between prostate cancer cells and associated fibroblasts” Antioxid Redox Signal. 2014 Mar 1;20(7):1045-59. IF: 7.468

57) Giannoni E and Chiarugi P “Redox circuitries during cell motility: Src at the leading edge” Antioxid Redox Signal. 2014 May 1;20(13):2011-25. IF: 7.468

58) Paoli P, Giannoni E and Chiarugi P “Anoikis molecular pathways and their role in cancer progression” Biochim Biophys Acta. - Molecular Cell Research 2013 Dec;1833(12):3481-98. IF: 5.011

59) Rapizzi E, Ercolino T, Fucci R, Zampetti B, Felici R, Guasti D, Morandi A, Giannoni E, Giaché V, Bani D, Chiarugi A, Mannelli M. “Succinate dehydrogenase subunit B mutations modify human neuroblastoma cell metabolism and proliferation.” Horm Cancer. 2014 Jun;5(3):174-84. IF: 4.667

60) Margheri F, Luciani C, Taddei ML, Giannoni E, Laurenzana A, Biagioni A, Chillà A, Chiarugi P, Fibbi G, Del Rosso M. “The receptor for urokinase-plasminogen activator (uPAR) controls plasticity of cancer cell movement in mesenchymal and amoeboid migration style.” Oncotarget. 2014 Mar 30;5(6):1538-53. IF 2016: 5.168

61) Taddei ML, Giannoni E, Morandi A, Ippolito L, Ramazzotti M, Callari M, Gandellini P, Chiarugi P. “Mesenchymal to amoeboid transition is associated with stem-like features of melanoma cells.” Cell Commun Signal. 2014 Apr 1;12:24. IF: 7.540

62) Lanciotti M, Masieri L, Raspollini MR, Minervini A, Mari A, Comito G, Giannoni E, Carini M, Chiarugi P, Serni S. “The role of M1 and M2 macrophages in prostate cancer in relation to extracapsular tumor extension and biochemical recurrence after radical prostatectomy.” Biomed Res Int. 2014;2014:486798. IF: 3.246

63) Taddei ML, Cavallini L, Comito G, Giannoni E, Folini M, Marini A, Gandellini P, Morandi A, Pintus G, Raspollini MR, Zaffaroni N, Chiarugi P. “Senescent stroma promotes prostate cancer progression: the role of miR-210.” Mol Oncol. 2014 Dec;8(8):1729-46. IF: 7.449

64) Calvani M, Pelon F, Comito G, Taddei ML, Moretti S, Innocenti S, Nassini R, Gerlini G, Borgognoni L, Bambi F, Giannoni E, Filippi L, Chiarugi P. “Norepinephrine promotes tumor microenvironment reactivity through β3-adrenoreceptors during melanoma progression.” Oncotarget. 2015 Mar 10;6(7):4615-32. IF 2016: 5.168

65) Rapizzi E, Fucci R, Giannoni E, Canu L, Richter S, Cirri P, Mannelli M. “Role of microenvironment on neuroblastoma SK-N-AS SDHB silenced cell metabolism and function.” Endocr Relat Cancer. 2015 Mar 25. IF: 5.905

66) Giannoni E, Taddei ML, Morandi A, Comito G, Calvani M, Bianchini F, Richichi B, Raugei G, Wong N, Tang D, Chiarugi P. “Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread.” Oncotarget. 2015 Sep 15;6(27):24061-74. IF 2016: 5.168

67) Maraldi T, Angeloni C, Giannoni E, Sell C “Reactive Oxygen Species in Stem Cells.” Oxid Med Cell Longev. 2015;2015:159080. doi: 10.1155/2015/159080. IF: 7.310

68) Doldi V, Callari M, Giannoni E, D'Aiuto F, Maffezzini M, Valdagni R, Chiarugi P, Gandellini P, Zaffaroni N. “Integrated gene and miRNA expression analysis of prostate cancer associated fibroblasts supports a prominent role for interleukin-6 in fibroblast activation.” Oncotarget. 2015 Oct 13;6(31):31441-60. IF 2016: 5.168

69) Corti D, Paoli P, Calvani M, Taddei ML, Giannoni E, Kopetz S, Kazmi SM, Pia MM, Pettazzoni P, Sacco E, Caselli A, Vanoni M, Landriscina M, Cirri P, Chiarugi P. “5-fluorouracil resistant colon cancer cells are addicted to OXPHOS to survive and enhance stem-like traits.” Oncotarget. 2015 Dec 8;6(39):41706-21. IF 2016: 5.168

70) Bacci M, Giannoni E, Fearns A, Ribas R, Gao Q, Taddei ML, Pintus G, Dowsett M, Isacke CM, Martin LA, Chiarugi P, Morandi A. “miR-155 Drives Metabolic Reprogramming of ER+ Breast Cancer Cells Following Long-Term Estrogen Deprivation and Predicts Clinical Response to Aromatase Inhibitors.” Cancer Res. 2016 Mar 15;76(6):1615-26. IF: 13.312

71) Comito G, Segura CP, Taddei ML, Lanciotti M, Serni S, Morandi A, Chiarugi P, Giannoni E. “Zoledronic acid impairs stromal reactivity by inhibiting M2-macrophages polarization and prostate cancer-associated fibroblasts.” Oncotarget. 2017 Jan 3;8(1):118-132. IF 2016: 5.168

72) Peppicelli S, Toti A, Giannoni E, Bianchini F, Margheri F, Del Rosso M, Calorini L. “Metformin is also effective on lactic acidosis-exposed melanoma cells switched to oxidative phosphorylation.” Cell Cycle. 2016 Jul 17;15(14):1908-18. IF: 5.173

73) Calvani M, Bianchini F, Taddei ML, Becatti M, Giannoni E, Chiarugi P, Calorini L. “Etoposide-Bevacizumab a new strategy against human melanoma cells expressing stem-like traits.” Oncotarget. 2016 Aug 9;7(32):51138-51149. IF 2016: 5.168

74) Ippolito L, Marini A, Cavallini L, Morandi A, Pietrovito L, Pintus G, Giannoni E, Schrader T, Puhr M, Chiarugi P, Taddei ML. “Metabolic shift toward oxidative phosphorylation in docetaxel resistant prostate cancer cells.” Oncotarget. 2016 Sep 20;7(38):61890-61904. IF 2016: 5.168

75) Morandi A, Giannoni E and Chiarugi P. “Nutrient Exploitation within the Tumor-Stroma Metabolic Crosstalk” Trends in Cancer, 2016 Dec;2(12):736-746. IF: 19.161

76) Pistore C*, Giannoni E*, Colangelo T, Rizzo F, Magnani E, Muccillo L, Giurato G, Mancini M, Rizzo S, Riccardi M, Sahnane N, Del Vescovo V, Kishore K, Mandruzzato M, Macchi F, Pelizzola M, Denti MA, Furlan D, Weisz A, Colantuoni V, Chiarugi P, Bonapace IM. “DNA methylation variations are required for epithelial-to-mesenchymal transition induced by cancer-associated fibroblasts in prostate cancer cells.” Oncogene. 2017 Jun 5. IF: 8.756

77) Morandi A, Taddei ML, Chiarugi P, Giannoni E “Targeting the Metabolic Reprogramming That Controls Epithelial-to-Mesenchymal Transition in Aggressive Tumors” Front Oncol.2017 Mar 14;7:40. IF: 5.738

78) Apicella M, Giannoni E, Fiore S, Ferrari KJ, Fernández-Pérez D, Isella C, Granchi C, Minutolo F, Sottile A, Comoglio PM, Medico E, Pietrantonio F, Volante M, Pasini D, Chiarugi P, Giordano S, Corso S. “Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies.” Cell Metab. 2018 Dec 4;28(6):848-865.e6. doi: 10.1016/j.cmet.2018.08.006. IF: 31.373

79) Taddei ML, Cavallini L, Ramazzotti M, Comito G, Pietrovito L, Morandi A, Giannoni E, Raugei G, Chiarugi P. “Stromal-induced downregulation of miR-1247 promotes prostate cancer malignancy.” J Cell Physiol. 2018 Oct 30. doi: 10.1002/jcp.27679. IF: 6.513

80) Ippolito L, Morandi A, Giannoni E, Chiarugi P “Lactate: A Metabolic Driver in the Tumour Landscape.” Trends Biochem Sci. 2019 Feb;44(2):153-166. doi: 10.1016/j.tibs.2018.10.011 IF: 14.264

81) Pietrovito L, Comito G, Parri M, Giannoni E, Chiarugi P, Taddei ML. “Zoledronic Acid Inhibits the RhoA-mediated Amoeboid Motility of Prostate Cancer Cells.” Curr Cancer Drug Targets. 2019 Jan 15. doi: 10.2174/1568009619666190115142858. IF: 2.907

82) Comito G, Iscaro A, Bacci M, Morandi A, Ippolito L, Parri M, Montagnani I, Raspollini MR, Serni S, Simeoni L, Giannoni E, Chiarugi P. “Lactate modulates CD4+ T-cell polarization and induces an immunosuppressive environment, which sustains prostate carcinoma progression via TLR8/miR21 axis.” Oncogene. 2019 Jan 21. doi: 10.1038/s41388-019-0688-7. IF: 8.756

83) Ippolito L, Morandi A, Taddei ML, Parri M, Comito G, Iscaro A, Raspollini MR, Magherini F, Rapizzi E, Masquelier J, Muccioli GG, Sonveaux P, Chiarugi P, Giannoni E. “Cancer-associated fibroblasts promote prostate cancer malignancy via metabolic rewiring and mitochondrial transfer.” Oncogene. 2019 Apr 1. doi: 10.1038/s41388-019-0805-7. IF: 8.756

84) Bacci M, Ippolito L, Magnelli L, Giannoni E, Chiarugi P. "Stromal-induced mitochondrial re-education: Impact on epithelial-to-mesenchymal transition and cancer aggressiveness.” Semin Cell Dev Biol. 2019 May 21. pii: S1084-9521(18)30218-0. doi: 10.1016/j.semcdb.2019.05.009. IF: 7.499

85) Bacci M, Lorito N, Ippolito L, Ramazzotti M, Luti S, Romagnoli S, Parri M, Bianchini F, Cappellesso F, Virga F, Gao Q, Simões BM, Marangoni E, Martin LA, Comito G, Ferracin M, Giannoni E, Mazzone M, Chiarugi P, Morandi A. “Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer.” Cell Rep. 2019 Jul 2;28(1):104-118.e8. doi: 10.1016/j.celrep.2019.06.010. IF: 9.995

86) Pietrovito L, Iozzo M, Bacci M, Giannoni E, Chiarugi P. “Treatment with Cannabinoids as a Promising Approach for Impairing Fibroblast Activation and Prostate Cancer Progression.” Int J Mol Sci. 2020 Jan 25;21(3). pii: E787. doi: 10.3390/ijms21030787. IF: 6.208

87) Lorito N, Bacci M, Smiriglia A, Mannelli M, Parri M, Comito G, Ippolito L, Giannoni E, Bonechi M, Benelli M, Migliaccio I, Malorni L, Chiarugi P, Morandi A. “Glucose Metabolic Reprogramming of ER Breast Cancer in Acquired Resistance to the CDK4/6 Inhibitor Palbociclib.” Cells. 2020 Mar 10;9(3). pii: E668. doi: 10.3390/cells9030668. IF: 7.666

88) Ippolito L, Giannoni E, Chiarugi P, Parri M. “Mitochondrial Redox Hubs as Promising Targets for Anticancer Therapy.” Front Oncol. 2020 Feb 28;10:256. doi:10.3389/fonc.2020.00256. IF: 5.738

89) Iozzo M, Sgrignani G, Comito G, Chiarugi P, Giannoni E. Endocannabinoid System and Tumour Microenvironment: New Intertwined Connections for Anticancer Approaches. Cells. 2021 Dec 2;10(12):3396. doi: 10.3390/cells10123396 IF: 7.666

90) Ippolito L, Comito G, Parri M, Iozzo M, Duatti A, Virgilio F, Lorito N, Bacci M, Pardella E, Sandrini G, Bianchini F, Damiano R, Ferrone L, la Marca G, Serni S, Spatafora P, Catapano CV, Morandi A, Giannoni E, Chiarugi P. Lactate Rewires Lipid Metabolism and Sustains a Metabolic-Epigenetic Axis in Prostate Cancer. Cancer Res. 2022 Apr 1;82(7):1267-1282. doi: 10.1158/0008-5472.CAN-21-0914 IF: 13.312

91) Pardella E, Ippolito L, Giannoni E, Chiarugi P. Nutritional and metabolic signalling through GPCRs. FEBS Lett. 2022 Sep;596(18):2364-2381. doi: 10.1002/1873-3468.14441 IF: 3.864

5) Giannoni E., Cirri P., Paoli P., Fiaschi T., Camici G., Manao G., Raugei G., Ramponi G. “Acylphosphatase is a strong apoptosis inducer in HeLa cell line”, Mol. Cell. Biol. Res. Commun. (2000), 3(5): 264-70. IF: ND

6) Chiarugi P., Fiaschi T., Taddei M.L., Talini D. Giannoni E., Raugei G., Ramponi G. “Two vicinal cysteines confer a peculiar redox regulation to low molecular weight protein tyrosine phosphatase in response to platelet-derived growth factor receptor stimulation.” J. Biol. Chem. (2001), 276(36): 33478-87. IF: 5.157

7) Paoli P., Giannoni E., Pescitelli R., Camici G., Manao G., Ramponi G. “Hydrogen peroxide triggers the formation of a disulfide dimer of muscle acylphosphatase and modifies some functional properties of the enzyme.” J. Biol. Chem. (2001) 276(45): 41862-9. IF: 5.157

8) Fiaschi T., Chiarugi P., Buricchi F., Giannoni E., Taddei M.L., Talini D., Cozzi G., Zecchi-Orlandini S., Raugei G., Ramponi G. “LMW-PTP is involved in growth inhibition during cell differentiation” J. Biol. Chem. (2001), 276(52): 49156-63. IF: 5.157

9) Bucciantini M.*, Giannoni E.*, Chiti F., Baroni F., Formigli L., Zurdo J., Taddei N., Dobson C.M., Stefani M. “Inherent toxicity of polypeptide aggregates suggests a common origin of protein misfolding disease” Nature (2002), 416(6880): 507-11. IF: 49.962

10) Chiarugi P., Cirri P., Taddei M.L., Talini D., Doria L., Fiaschi T., Buricchi F., Giannoni E., Camici G., Raugei G., Ramponi G. “New perspectives in PDGF receptor downregulation: the main role of phosphotyrosine phosphatases” J. Cell. Sci. (2002), 115(Pt 10): 2219-32. IF: 5.285

11) Chiarugi P., Cirri P., Taddei M.L., Giannoni E., Fiaschi T., Buricchi F., Camici G., Raugei G., Ramponi G. “Insight into the role of low molecular weight phosphotyrosine phosphatase (LMW-PTP) on platelet-derived growth factor receptor (PDGF-r) signaling. LMW-PTP controls PDGF-r kinase activity through TYR-857 dephosphorylation” J. Biol. Chem. 2002 Oct 4;277(40):37331-8 IF: 5.157

12) Taddei M.L., Chiarugi P., Cirri P., Buricchi F., Fiaschi T., Giannoni E., Talini D., Cozzi G., Formigli L., Raugei G., Ramponi G. “Beta-catenin interacts with Low-Molecular-Weight Protein Tyrosine Phosphatase leading to cadherin-mediated cell-cell adhesion increase” Cancer Res 2002 Nov 15;62(22):6489-99. IF: 12.701

13) Paoli P., Pazzagli L., Giannoni E., Caselli A., Manao G., Camici G., Ramponi G. “A Nucleophilic Catalysis Step is Involved in the Hydrolysis of Aryl Phosphate Monoesters by Human CT Acylphosphatase.” J. Biol. Chem. 2003 Jan 3; 278(1): 194-9 IF: 5.157

14) Iantomasi T., Favilli F., Catarzi S., Giannoni E., Biagioni C., Vincenzini MT. “Involvement of the tyrosine phosphorylation on GSH transport in NIH3T3 fibroblasts.” IUBMB Life. 2003 Mar;55(3):159-65. IF: 3.885

15) Chiarugi P., Pani G., Giannoni E., Taddei M.L., Colavitti R., Raugei G., Symons M., Borrello S., Galeotti T., Ramponi G. “Reactive oxygen species as essential mediators of cell
adhesion: the oxidative inhibition of a FAK tyrosine phosphatase is required for cell adhesion” J. Cell. Biol. 2003 Jun 9;161(5):933-44 IF: 10.539

16) Giannoni E., Chiarugi P., Cozzi G., Magnelli L., Taddei M. L., Fiaschi T., Buricchi F., Raugei G., Ramponi G. “LFA-1 mediated T cell adhesion is impaired by Low Molecular Weight phosphotyrosine phosphatase-dependent inhibition of FAK activity” J. Biol. Chem. 2003 Sep 19;278(38):36763-76. IF: 5.157

17) Fiaschi T., Chiarugi P., Buricchi F., Giannoni E., Taddei M. L., Magnelli L., Cozzi G., Raugei G., Ramponi G. “Down-regulation of PDGF receptor signaling during myogenesis.” Cell. Mol. Life. Sc. 2003 Dec;60(12):2721-35 IF: 9.261

18) Chiarugi P., Taddei M. L., Schiavone N., Papucci L., Giannoni E., Capaccioli S., Raugei G., Ramponi G. “LMW-PTP is a positive regulator of tumor onset and growth” Oncogene 2004 May 13;23(22):3905-14. IF: 9.867

19) Ventura S., Zurdo J., Narayanan S., Parreno M., Mangues R., Reif B., Chiti F., Giannoni E., Dobson C.M., Aviles F.X., Serrano L. “Short amino acid stretches can mediate amyloid formation in globular proteins: the Src homology 3 (SH3) case.” Proc Natl Acad Sci U S A. 2004 May 11;101(19):7258-63 IF: 11.205

20) Cecchi C., Liguri G., Fiorillo C., Bogani F., Gambassi M., Giannoni E., Cirri P., Baglioni S., Ramponi G. “Acylphosphatase overexpression triggers SH-SY5Y differentiation towards neuronal phenotype.” Cell. Mol. Life Sci. 2004 Jul;61(14):1775-84. IF: 9.261

21) Cirri P., Taddei M.L., Chiarugi P., Buricchi F., Caselli A., Paoli P., Giannoni E., Camici G., Manao G., Raugei G., Ramponi G. “Insulin inhibits PDGF-induced cell proliferation” Mol Biol Cell. 2005 Jan;16(1):73-83. IF: 4.138

22) Chiarugi P. and Giannoni E. “Anchorage-dependent cell growth: tyrosine kinases and phosphatases meet redox regulation” Antioxid Redox Signal. 2005 May-Jun;7(5-6):578-92. IF: 8.401

23) Giannoni E., Buricchi F., Raugei G., Ramponi G., Chiarugi P. “Intracellular Reactive Oxygen Species Activate Src Tyrosine Kinase during Cell Adhesion and Anchorage-Dependent Cell Growth.” Mol Cell Biol. 2005 Aug;25(15):6391-403. IF: 4.272

24) Parri M, Buricchi F, Taddei ML, Giannoni E, Raugei G, Ramponi G, Chiarugi P. " EphrinA1 repulsive response is regulated by an EphA2 tyrosine phosphatase." J. Biol. Chem. 2005 Oct 7;280(40):34008-18. IF: 5.157

25) Catarzi S, Biagioni C, Giannoni E, Favilli F, Marcucci T, Iantomasi T, Vincenzini MT. "Redox regulation of platelet-derived-growth-factor-receptor: role of NADPH-oxidase and c-Src tyrosine kinase." Biochim Biophys Acta. - Molecular Cell Research 2005 Sep 10;1745(2):166-75. IF: 4.739

26) Buricchi F, Chiarugi P, Fiaschi T, Giannoni E, Magnelli L, Fanti E, Raugei G, Ramponi G. "During muscle ageing the activation of the mitogenic signalling is not sufficient to guarantee cellular duplication." Ital J Biochem. 2005 Sep-Dec;54(3-4):258-67. IF: ND

27) Giannoni E, Raugei G, Chiarugi P, Ramponi G. "A novel redox-based switch: LMW-PTP oxidation enhances Grb2 binding and leads to ERK activation." Biochem Biophys Res Commun. 2006 Sep 22;348(2):367-73. IF: 3.575

28) Catarzi S, Giannoni E, Favilli F, Meacci E, Iantomasi T, Vincenzini MT. "Sphingosine 1-phosphate stimulation of NADPH oxidase activity: Relationship with platelet-derived growth factor receptor and c-Src kinase." Biochim Biophys Acta. - General Subjects 2007 Jun;1770(6):872-83. IF: 3.770

29) Parri M, Buricchi F, Giannoni E, Grimaldi G, Mello T, Raugei G, Ramponi G, Chiarugi P. "Ephrin-A1 activates a SRC/FAK-mediated motility response leading to RHO-dependent ACTINO/MYOSIN contractility." J. Biol. Chem. 2007 Apr 22 IF: 5.157

30) Buricchi F, Giannoni E., Grimaldi G., Parri M., Raugei G, Ramponi G, Chiarugi P. " Redox regulation of Ephrin/Integrin cross-talk" Cell Adhesion & Migration 1:1, 33-42; January/February/March 2007 IF: 3.405

31) Giannoni E, Buricchi F, Grimaldi G, Parri M, Cialdai F, Taddei ML, Raugei G, Ramponi G, Chiarugi P. “Redox regulation of anoikis: reactive oxygen species as essential mediators of cell survival.” Cell Death Differ. 2008 May;15(5):867-78. IF: 15.828

32) Chiarugi P. Giannoni E. “Anoikis: a necessary death program for anchorage-dependent cells.” Biochem Pharmacol. 2008 Dec 1;76(11):1352-64. IF: 5.858

33) Taddei ML, Parri M, Angelucci A, Onnis B, Bianchini F, Giannoni E, Raugei G, Calorini L, Rucci N, Teti A, Bologna M, Chiarugi P. "Kinase-dependent and -independent roles of EphA2 in the regulation of prostate cancer invasion and metastasis.” Am J Pathol. 2009 Apr;174(4):1492-503. IF: 4.307

34) Giannoni E, Fiaschi T, Ramponi G, Chiarugi P. “Redox regulation of anoikis resistance of metastatic prostate cancer cells: key role for Src and EGFR-mediated pro-survival signals.” Oncogene. 2009 May 21;28(20):2074-86. IF: 9.867

35) Pani G, Giannoni E, Galeotti T, Chiarugi P. “Redox-based escape mechanism from death: the cancer lesson.” Antioxid Redox Signal. 2009 Nov;11(11):2791-806. IF: 8.401

36) Fiaschi T, Tedesco FS, Giannoni E, Diaz-Manera J, Parri M, Cossu G, Chiarugi P. “Globular adiponectin as a complete mesangioblast regulator: role in proliferation, survival, motility and skeletal muscle differentiation.” Mol Biol Cell. 2010 Mar;21(6):848-59. IF: 4.138

37) Giannoni E, Taddei ML, Chiarugi P. “Src redox regulation: again in the front line.” Free Radic Biol Med. 2010 Aug 15;49(4):516-27. IF: 7.376

38) Giannoni E, Bianchini F, Masieri L, Serni S, Torre E, Calorini L, Chiarugi P. “Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness.” Cancer Res. 2010 Sep 1;70(17):6945-56. IF: 12.701

39) Taddei ML, Parri M, Angelucci A, Bianchini F, Marconi C, Giannoni E, Raugei G, Bologna M, Calorini L, Chiarugi P. “EphA2 induces metastatic growth regulating amoeboid motility and clonogenic potential in prostate carcinoma cells.” Mol Cancer Res. 2011 Feb;9(2):149-60. IF: 5.852

40) Giannoni E, Bianchini F, Calorini L, Chiarugi P. “Cancer associated fibroblasts exploit reactive oxygen species through a proinflammatory signature leading to epithelial mesenchymal transition and stemness.” Antioxid Redox Signal. 2011 Jun 15;14(12):2361-71. IF: 8.401

41) Comito G, Calvani M, Giannoni E, Bianchini F, Calorini L, Torre E, Migliore C, Giordano S, Chiarugi P. “HIF-1α stabilization by mitochondrial ROS promotes Met-dependent invasive growth and vasculogenic mimicry in melanoma cells.” Free Radic Biol Med. 2011 Aug 15;51(4):893-904. IF: 7.376

42) Taddei ML, Giannoni E, Fiaschi T, Chiarugi P. “Anoikis: an emerging hallmark in health and diseases. J Pathol. 2012 Jan;226(2):380-93. IF: 7.996

43) Giannoni E, Parri M, Chiarugi P. “EMT and Oxidative Stress: A Bidirectional Interplay Affecting Tumor Malignancy.” Antioxid Redox Signal. 2012 Jun 1;16(11):1248-63. IF: 8.401

44) Taddei ML, Giannoni E, Raugei G, Scacco S, Sardanelli AM, Papa S, Chiarugi P. “Mitochondrial Oxidative Stress due to Complex I Dysfunction Promotes Fibroblast Activation and Melanoma Cell Invasiveness.” J Signal Transduct. 2012;2012:684592. IF 2016: 2.2

45) Bianchini F, Giannoni E, Serni S, Chiarugi P, Calorini L. “22:6n-3 DHA inhibits differentiation of prostate fibroblasts into myofibroblasts and tumorigenesis.” Br J Nutr. 2012 Mar 6:1-9. IF: 3.718

46) Fiaschi T, Giannoni E, Taddei ML, Chiarugi P. “Globular adiponectin activates motility and regenerative traits of muscle satellite cells.” PLoS One. 2012;7(5):e34782. IF: 3.240

47) Comito G, Giannoni E, Di Gennaro P, Segura CP, Gerlini G, Chiarugi P. “Stromal fibroblasts synergize with hypoxic oxidative stress to enhance melanoma aggressiveness.” Cancer Lett. 2012 Nov 1;324(1):31-41. IF: 8.679

48) Fiaschi T, Marini A, Giannoni E, Taddei ML, Gandellini P, De Donatis A, Lanciotti M, Serni S, Cirri P, Chiarugi P. “Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay.” Cancer Res. 2012 Oct 1;72(19):5130-40. IF: 12.701

49) Giannoni E, Taddei ML, Parri M, Bianchini F, Santosuosso M, Grifantini R, Fibbi G, Mazzanti B, Calorini L, Chiarugi P. “EphA2-mediated mesenchymal-amoeboid transition induced by endothelial progenitor cells enhances metastatic spread due to cancer-associated fibroblasts.” J Mol Med (Berl). 2013 Jan;91(1):103-15. IF: 4.599

50) Pitozzi V, Mocali A, Laurenzana A, Giannoni E, Cifola I, Battaglia C, Chiarugi P, Dolara P, Giovannelli L. “Chronic Resveratrol Treatment Ameliorates Cell Adhesion and Mitigates the Inflammatory Phenotype in Senescent Human Fibroblasts.” J Gerontol A Biol Sci Med Sci. 2012 Aug 29. IF: 6.053

51) Serratì S, Chillà A, Laurenzana A, Margheri F, Giannoni E, Magnelli L, Chiarugi P, Dotor J, Feijoo E, Bazzichi L, Bombardieri S, Kahaleh B, Fibbi G, Del Rosso M. “Systemic sclerosis endothelial cells recruit and activate dermal fibroblasts by induction of a connective tissue growth factor (CCN2)/transforming growth factor β-dependent mesenchymal-to-mesenchymal transition.” Arthritis Rheum. 2013 Jan;65(1):258-69. IF: 10.995

52) Calvani M, Comito G, Giannoni E, Chiarugi P. “Time-dependent stabilization of hypoxia inducible factor-1α by different intracellular sources of reactive oxygen species.” PLoS One. 2012;7(10):e38388. IF: 3.240

53) Taddei ML, Giannoni E, Comito G, Chiarugi P. “Microenvironment and tumor cell plasticity: An easy way out.” Cancer Lett. 2013 Nov 28;341(1):80-96. IF: 8.679

54) Fiaschi T, Giannoni E, Taddei ML, Cirri P, Marini A, Pintus G, Nativi C, Richichi B, Scozzafava A, Carta F, Torre E, Supuran CT, Chiarugi P. “Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells”. Cell Cycle. 2013 May 8;12(11). IF: 4.534

55) Comito G, Giannoni E, Pons Segura C, Barcellos-de-Souza P, Raspollini MR, Baroni G, Lanciotti M, Serni S and Chiarugi P “Cancer associated fibroblasts and M2 polarized macrophages synergize during prostate carcinoma progression” Oncogene. 2014 May 8;33(19):2423-31. IF: 9.867

56) Gandellini P*, Giannoni E*, Casamichele A, Taddei ML, Callari C, Valdagni R, Pierotti MA, Zaffaroni N and Chiarugi P “miR-205 hinders the malignant interplay between prostate cancer cells and associated fibroblasts” Antioxid Redox Signal. 2014 Mar 1;20(7):1045-59. IF: 8.401

57) Giannoni E and Chiarugi P “Redox circuitries during cell motility: Src at the leading edge” Antioxid Redox Signal. 2014 May 1;20(13):2011-25. IF: 8.401

58) Paoli P, Giannoni E and Chiarugi P “Anoikis molecular pathways and their role in cancer progression” Biochim Biophys Acta. - Molecular Cell Research 2013 Dec;1833(12):3481-98. IF: 4.739

59) Rapizzi E, Ercolino T, Fucci R, Zampetti B, Felici R, Guasti D, Morandi A, Giannoni E, Giaché V, Bani D, Chiarugi A, Mannelli M. “Succinate dehydrogenase subunit B mutations modify human neuroblastoma cell metabolism and proliferation.” Horm Cancer. 2014 Jun;5(3):174-84. IF: 3.869

60) Margheri F, Luciani C, Taddei ML, Giannoni E, Laurenzana A, Biagioni A, Chillà A, Chiarugi P, Fibbi G, Del Rosso M. “The receptor for urokinase-plasminogen activator (uPAR) controls plasticity of cancer cell movement in mesenchymal and amoeboid migration style.” Oncotarget. 2014 Mar 30;5(6):1538-53. IF 2016: 5.168

61) Taddei ML, Giannoni E, Morandi A, Ippolito L, Ramazzotti M, Callari M, Gandellini P, Chiarugi P. “Mesenchymal to amoeboid transition is associated with stem-like features of melanoma cells.” Cell Commun Signal. 2014 Apr 1;12:24. IF: 5.712

62) Lanciotti M, Masieri L, Raspollini MR, Minervini A, Mari A, Comito G, Giannoni E, Carini M, Chiarugi P, Serni S. “The role of M1 and M2 macrophages in prostate cancer in relation to extracapsular tumor extension and biochemical recurrence after radical prostatectomy.” Biomed Res Int. 2014;2014:486798. IF: 3.411

63) Taddei ML, Cavallini L, Comito G, Giannoni E, Folini M, Marini A, Gandellini P, Morandi A, Pintus G, Raspollini MR, Zaffaroni N, Chiarugi P. “Senescent stroma promotes prostate cancer progression: the role of miR-210.” Mol Oncol. 2014 Dec;8(8):1729-46. IF: 6.603

64) Calvani M, Pelon F, Comito G, Taddei ML, Moretti S, Innocenti S, Nassini R, Gerlini G, Borgognoni L, Bambi F, Giannoni E, Filippi L, Chiarugi P. “Norepinephrine promotes tumor microenvironment reactivity through β3-adrenoreceptors during melanoma progression.” Oncotarget. 2015 Mar 10;6(7):4615-32. IF 2016: 5.168

65) Rapizzi E, Fucci R, Giannoni E, Canu L, Richter S, Cirri P, Mannelli M. “Role of microenvironment on neuroblastoma SK-N-AS SDHB silenced cell metabolism and function.” Endocr Relat Cancer. 2015 Mar 25. IF: 5.678

66) Giannoni E, Taddei ML, Morandi A, Comito G, Calvani M, Bianchini F, Richichi B, Raugei G, Wong N, Tang D, Chiarugi P. “Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread.” Oncotarget. 2015 Sep 15;6(27):24061-74. IF 2016: 5.168

67) Maraldi T, Angeloni C, Giannoni E, Sell C “Reactive Oxygen Species in Stem Cells.” Oxid Med Cell Longev. 2015;2015:159080. doi: 10.1155/2015/159080. IF: 6.543

68) Doldi V, Callari M, Giannoni E, D'Aiuto F, Maffezzini M, Valdagni R, Chiarugi P, Gandellini P, Zaffaroni N. “Integrated gene and miRNA expression analysis of prostate cancer associated fibroblasts supports a prominent role for interleukin-6 in fibroblast activation.” Oncotarget. 2015 Oct 13;6(31):31441-60. IF 2016: 5.168

69) Corti D, Paoli P, Calvani M, Taddei ML, Giannoni E, Kopetz S, Kazmi SM, Pia MM, Pettazzoni P, Sacco E, Caselli A, Vanoni M, Landriscina M, Cirri P, Chiarugi P. “5-fluorouracil resistant colon cancer cells are addicted to OXPHOS to survive and enhance stem-like traits.” Oncotarget. 2015 Dec 8;6(39):41706-21. IF 2016: 5.168

70) Bacci M, Giannoni E, Fearns A, Ribas R, Gao Q, Taddei ML, Pintus G, Dowsett M, Isacke CM, Martin LA, Chiarugi P, Morandi A. “miR-155 Drives Metabolic Reprogramming of ER+ Breast Cancer Cells Following Long-Term Estrogen Deprivation and Predicts Clinical Response to Aromatase Inhibitors.” Cancer Res. 2016 Mar 15;76(6):1615-26. IF: 12.701

71) Comito G, Segura CP, Taddei ML, Lanciotti M, Serni S, Morandi A, Chiarugi P, Giannoni E. “Zoledronic acid impairs stromal reactivity by inhibiting M2-macrophages polarization and prostate cancer-associated fibroblasts.” Oncotarget. 2017 Jan 3;8(1):118-132. IF 2016: 5.168

72) Peppicelli S, Toti A, Giannoni E, Bianchini F, Margheri F, Del Rosso M, Calorini L. “Metformin is also effective on lactic acidosis-exposed melanoma cells switched to oxidative phosphorylation.” Cell Cycle. 2016 Jul 17;15(14):1908-18. IF: 4.534

73) Calvani M, Bianchini F, Taddei ML, Becatti M, Giannoni E, Chiarugi P, Calorini L. “Etoposide-Bevacizumab a new strategy against human melanoma cells expressing stem-like traits.” Oncotarget. 2016 Aug 9;7(32):51138-51149. IF 2016: 5.168

74) Ippolito L, Marini A, Cavallini L, Morandi A, Pietrovito L, Pintus G, Giannoni E, Schrader T, Puhr M, Chiarugi P, Taddei ML. “Metabolic shift toward oxidative phosphorylation in docetaxel resistant prostate cancer cells.” Oncotarget. 2016 Sep 20;7(38):61890-61904. IF 2016: 5.168

75) Morandi A, Giannoni E and Chiarugi P. “Nutrient Exploitation within the Tumor-Stroma Metabolic Crosstalk” Trends in Cancer, 2016 Dec;2(12):736-746. IF: 14.226

76) Pistore C*, Giannoni E*, Colangelo T, Rizzo F, Magnani E, Muccillo L, Giurato G, Mancini M, Rizzo S, Riccardi M, Sahnane N, Del Vescovo V, Kishore K, Mandruzzato M, Macchi F, Pelizzola M, Denti MA, Furlan D, Weisz A, Colantuoni V, Chiarugi P, Bonapace IM. “DNA methylation variations are required for epithelial-to-mesenchymal transition induced by cancer-associated fibroblasts in prostate cancer cells.” Oncogene. 2017 Jun 5. IF: 9.867

77) Morandi A, Taddei ML, Chiarugi P, Giannoni E “Targeting the Metabolic Reprogramming That Controls Epithelial-to-Mesenchymal Transition in Aggressive Tumors” Front Oncol. 2017 Mar 14;7:40. IF: 6.244

78) Apicella M, Giannoni E, Fiore S, Ferrari KJ, Fernández-Pérez D, Isella C, Granchi C, Minutolo F, Sottile A, Comoglio PM, Medico E, Pietrantonio F, Volante M, Pasini D, Chiarugi P, Giordano S, Corso S. “Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies.” Cell Metab. 2018 Dec 4;28(6):848-865.e6. doi: 10.1016/j.cmet.2018.08.006. IF: 27.287

79) Taddei ML, Cavallini L, Ramazzotti M, Comito G, Pietrovito L, Morandi A, Giannoni E, Raugei G, Chiarugi P. “Stromal-induced downregulation of miR-1247 promotes prostate cancer malignancy.” J Cell Physiol. 2018 Oct 30. doi: 10.1002/jcp.27679. IF: 6.384

80) Ippolito L, Morandi A, Giannoni E, Chiarugi P “Lactate: A Metabolic Driver in the Tumour Landscape.” Trends Biochem Sci. 2019 Feb;44(2):153-166. doi: 10.1016/j.tibs.2018.10.011 IF: 13.807

81) Pietrovito L, Comito G, Parri M, Giannoni E, Chiarugi P, Taddei ML. “Zoledronic Acid Inhibits the RhoA-mediated Amoeboid Motility of Prostate Cancer Cells.” Curr Cancer Drug Targets. 2019 Jan 15. doi: 10.2174/1568009619666190115142858. IF: 3.428

82) Comito G, Iscaro A, Bacci M, Morandi A, Ippolito L, Parri M, Montagnani I, Raspollini MR, Serni S, Simeoni L, Giannoni E, Chiarugi P. “Lactate modulates CD4+ T-cell polarization and induces an immunosuppressive environment, which sustains prostate carcinoma progression via TLR8/miR21 axis.” Oncogene. 2019 Jan 21. doi: 10.1038/s41388-019-0688-7. IF: 9.867

83) Ippolito L, Morandi A, Taddei ML, Parri M, Comito G, Iscaro A, Raspollini MR, Magherini F, Rapizzi E, Masquelier J, Muccioli GG, Sonveaux P, Chiarugi P, Giannoni E. “Cancer-associated fibroblasts promote prostate cancer malignancy via metabolic rewiring and mitochondrial transfer.” Oncogene. 2019 Apr 1. doi: 10.1038/s41388-019-0805-7. IF: 9.867

84) Bacci M, Ippolito L, Magnelli L, Giannoni E, Chiarugi P. "Stromal-induced mitochondrial re-education: Impact on epithelial-to-mesenchymal transition and cancer aggressiveness.” Semin Cell Dev Biol. 2019 May 21. pii: S1084-9521(18)30218-0. doi: 10.1016/j.semcdb.2019.05.009. IF: 7.727

85) Bacci M, Lorito N, Ippolito L, Ramazzotti M, Luti S, Romagnoli S, Parri M, Bianchini F, Cappellesso F, Virga F, Gao Q, Simões BM, Marangoni E, Martin LA, Comito G, Ferracin M, Giannoni E, Mazzone M, Chiarugi P, Morandi A. “Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer.” Cell Rep. 2019 Jul 2;28(1):104-118.e8. doi: 10.1016/j.celrep.2019.06.010. IF: 9.423

86) Pietrovito L, Iozzo M, Bacci M, Giannoni E, Chiarugi P. “Treatment with Cannabinoids as a Promising Approach for Impairing Fibroblast Activation and Prostate Cancer Progression.” Int J Mol Sci. 2020 Jan 25;21(3). pii: E787. doi: 10.3390/ijms21030787. IF: 5.923

87) Lorito N, Bacci M, Smiriglia A, Mannelli M, Parri M, Comito G, Ippolito L, Giannoni E, Bonechi M, Benelli M, Migliaccio I, Malorni L, Chiarugi P, Morandi A. “Glucose Metabolic Reprogramming of ER Breast Cancer in Acquired Resistance to the CDK4/6 Inhibitor Palbociclib.” Cells. 2020 Mar 10;9(3). pii: E668. doi: 10.3390/cells9030668. IF: 6.600

88) Ippolito L, Giannoni E, Chiarugi P, Parri M. “Mitochondrial Redox Hubs as Promising Targets for Anticancer Therapy.” Front Oncol. 2020 Feb 28;10:256. doi:10.3389/fonc.2020.00256. IF: 6.244

Elisa GIANNONI

Curriculum

Elisa Giannoni è Professore Ordinario di Biochimica (BIO/10) presso la Scuola di Scienze della Salute Umana dell’Università di Firenze ed afferente al Dipartimento di Scienze Biomediche Sperimentali e Cliniche.

1997- consegue la Laurea in Scienze Biologiche presso l'Università degli Studi di Firenze.

1997-1998- svolge il tirocinio post-laurea presso il Dipartimento di Scienze Biochimiche dell'Università degli Studi di Firenze.

1998- sostiene e supera l’Esame di Stato per il conseguimento dell’Abilitazione alla professione di Biologo.

2002- ottiene il titolo di Dottorato di Ricerca in Biochimica.

2002-2005- ottiene un assegno di ricerca da svolgersi presso il Dipartimento di Scienze Biochimiche dell'Università degli Studi di Firenze.

2005- prende servizio come Professore Associato nel settore scientifico disciplinare M-EDF/01 Metodi e Didattiche delle Attività Motorie e prende afferenza presso il Dipartimento di Scienze Biochimiche.

2013- ottiene il passaggio di SSD da M-EDF/01 (Metodi e Didattiche delle Attività Motorie) a BIO/10 (Biochimica) e si incardina nel ruolo di Professore Associato nel settore scientifico disciplinare BIO/10.

2023- ottiene la progressione di carriiera a Professore Odinario nel settore scientifico disciplinare BIO/10.

Elisa GIANNONI

Interessi

Elisa Giannoni ha una solida esperienza nel campo della ricerca oncologica. Ha studiato per 5 anni il ruolo dello stress ossidativo nel cancro, portando all'identificazione delle proteine regolate dalla generazione di stresso ossidativo durante la proliferazione cellulare e l'adesione cellulare alla matrice extracellulare. Ha inoltre contribuito agli studi sulla proliferazione ancoraggio-indipendente e sulla resistenza all'anoikis delle cellule tumorali e sulla delucidazione dei mediatori di segnalazione che contribuiscono al raggiungimento di queste capacità. Nell'ultimo decennio, il suo interesse si è concentrato sullo studio del microambiente tumorale, concentrandosi in particolare sui fibroblasti associati al cancro, sulle cellule endoteliali e sulle cellule immunitarie (macrofagi associati al cancro e linfociti infiltranti il tumore). In particolare, ha studiato la plasticità della motilità delle cellule tumorali (come transizione epiteliale-mesenchimale o transizione mesenchimale-ameboide), identificando importanti processi molecolari che guidano questo processo. Più recentemente, ha concentrato i suoi studi sulla plasticità metabolica delle cellule tumorali dovuta all'interazione con il microambiente tumorale, con un interesse particolare all'impatto della riprogrammazione metabolica indotta dallo stroma sulla regolazione epigenetica della malignità delle cellule tumorali.

L'obiettivo generale della ricerca condotta dal suo team è la scoperta di strategie innovative per il trattamento del cancro basate su una profonda conoscenza della complessa interazione tra i processi epigenetici, trascrizionali e metabolici alla base dello sviluppo del cancro.

I risultati rilevanti dei suoi studi sono stati pubblicati su riviste internazionali e contribuiscono a migliorare la conoscenza sui meccanismi molecolari che sono alla base della patogenesi e della progressione dei tumori umani.

Elisa GIANNONI

Note

Elisa Giannoni è membro del comitato editoriale di riviste internazionali tra cui Frontiers in Cell and Developmental Biology, Frontiers in Oncology, Cells and Cancers. È stata anche redattrice per Hindawi Publishing Corporation, “Oxidative Medicine and Cellular Longevity” - Numero speciale “ROS and Stem Cell”.

Svolge anche il ruolo di revisore per riviste scientifiche internazionali (tra cui Cancer Research, eLife, Journal of Cell Biology, Science Signaling, Frontiers in Cell and Developmental Biology, Frontiers in Oncology, Cells and Cancers).

Elisa Giannoni è membro della Società Italiana di Biochimica (SIB), della Società Italiana di Cancerologia (SIC), dell'Associazione Europea di Ricerca sul Cancro (EACR) e dell'America Association of Cancer Research (AACR). È inoltre membro del comitato scientifico dell'Università di Firenze per le borse di studio dal 2017 e membro del comitato scientifico per la valutazione delle Sir Henry Wellcome Postdoctoral Fellowships (UK).

Elisa Giannoni ha ricevuto finanziamenti da enti finanziatori nazionali e tra i recenti:

- MIUR (PRIN2022 PNRR): “Role of lactate as a metabolic regulator of ferroptosis sensitivity and metastatic dissemination in cancer cells” (2023-2025) - RESPONSABILE DELL'UNITÀ DI RICERCA

- MIUR (PRIN2022): “Metabolic alterations and immune escape in colorectal cancer: activity metabolomics as a novel therapeutic approach” (2023-2025) - RESPONSABILE DELL'UNITÀ DI RICERCA

- MUR Piano Nazionale di Ripresa e Resilienza, Missione 4 Componente 2 - Investimento 1.4 Potenziamento strutture di ricerca e creazione di "campioni nazionali di R&S" su alcune Key Enabling Technologies - finanziato dall’Unione europea – NextGenerationEU - Spoke 2 - Cancer - CN 3 - Centro nazionale di Ricerca Sviluppo di terapia genica e farmaci con tecnologia a RNA (2022-2025) – COORDINATORE DEL PROGETTO DI RICERCA

- Progetti di ricerca competitivi della durata di 30 mesi nell'ambito delle tematiche del PNR 2021-2027 Bando di Ateneo (2023-2026) PARTECIPANTE

- MUR - Excellent Departments- Gender Medicine Program: “Gender impact on the metabolic-related immune surveillance in melanoma” (2020-2022) - COORDINATORE DEL PROGETTO DI RICERCA

- Associazione Italiana Ricerca contro il Cancro (AIRC - Investigator Grant 2020): “Deciphering the lactate-driven metabolic and epigenetic reprogramming in prostate cancer” (2020-2025) PARTECIPANTE

- MIUR (PRIN2017): “Role of nutrients in the epigenetic control of prostate cancer progression” (2018-2022) PARTECIPANTE

- Associazione Italiana Ricerca contro il Cancro (AIRC - Investigator Grant 2015) “Metabolic deregulation towards OXPHOS in malignant cancers: role of miRNAs” (2016-2019) PARTECIPANTE

- Fondazione Umberto Veronesi: RESPONSABILE SCIENTIFICO per un Contratto di Ricerca conferito alla Dr. Comito Giuseppina sul progetto: “Role of tumor microenvironment in immune modulation during prostate carcinoma progression”.

Ad oggi Elisa Giannoni conta 91 pubblicazioni su riviste peer-review, con un Impact Factor (IF) totale di 695.8 (IF medio per pubblicazione: 7,64), un numero totale di citazioni di 10.705 e un H-index di 48 (Scopus).

Elisa GIANNONI

Pubblicazioni

Legenda

Contributo su rivista |

Articolo su libro |

Libro |

Contributo in atti di convegno (proceeding) |

Brevetto |

Curatela | Altro

Altro |

Tesi di Dottorato

Ippolito, Luigi; Duatti, Assia; Iozzo, Marta; Comito, Giuseppina; Pardella, Elisa; Lorito, Nicla; Bacci, Marina; Pranzini, Erica; Santi, Alice; Sandrini, Giada; Catapano, Carlo V; Serni, Sergio; Spatafora, Pietro; Morandi, Andrea; Giannoni, Elisa; Chiarugi, Paola (2024). Lactate supports cell-autonomous ECM production to sustain metastatic behavior in prostate cancer. EMBO REPORTS, pp. 0-0, ISSN:1469-3178 DOI

Lorito, Nicla; Subbiani, Angela; Smiriglia, Alfredo; Bacci, Marina; Bonechi, Francesca; Tronci, Laura; Romano, Elisabetta; Corrado, Alessia; Longo, Dario Livio; Iozzo, Marta; Ippolito, Luigi; Comito, Giuseppina; Giannoni, Elisa; Meattini, Icro; Avgustinova, Alexandra; Chiarugi, Paola; Bachi, Angela; Morandi, Andrea (2024). FADS1/2 control lipid metabolism and ferroptosis susceptibility in triple-negative breast cancer. EMBO MOLECULAR MEDICINE, pp. 0-0, ISSN:1757-4684 DOI

Bacci, Marina; Lorito, Nicla; Smiriglia, Alfredo; Subbiani, Angela; Bonechi, Francesca; Comito, Giuseppina; Morriset, Ludivine; El Botty, Rania; Benelli, Matteo; López-Velazco, Joanna I; Caffarel, Maria M; Urruticoechea, Ander; Sflomos, George; Malorni, Luca; Corsini, Michela; Ippolito, Luigi; Giannoni, Elisa; Meattini, Icro; Matafora, Vittoria; Havas, Kristina; Bachi, Angela; Chiarugi, Paola; Marangoni, Elisabetta; Morandi, Andrea (2024). Acetyl-CoA carboxylase 1 controls a lipid droplet-peroxisome axis and is a vulnerability of endocrine-resistant ER+ breast cancer. SCIENCE TRANSLATIONAL MEDICINE, vol. 16, pp. 0-0, ISSN:1946-6242 DOI

Pranzini, Erica; Ippolito, Luigi; Pardella, Elisa; Giannoni, Elisa; Chiarugi, Paola (2024). Adapt and shape: metabolic features within the metastatic niche. TRENDS IN ENDOCRINOLOGY AND METABOLISM, pp. 0-0, ISSN:1043-2760 DOI

Elisa Pardella, Luigi Ippolito, Elisa Giannoni, Paola Chiarugi (2022). Nutritional and metabolic signalling through GPCRs. FEBS LETTERS, vol. 596, pp. 2364-2381, ISSN:0014-5793 DOI

Ippolito, Luigi; Comito, Giuseppina; Parri, Matteo; Iozzo, Marta; Duatti, Assia; Virgilio, Francesca; Lorito, Nicla; Bacci, Marina; Pardella, Elisa; Sandrini, Giada; Bianchini, Francesca; Damiano, Roberta; Ferrone, Lavinia; la Marca, Giancarlo; Serni, Sergio; Spatafora, Pietro; Catapano, Carlo V; Morandi, Andrea; Giannoni, Elisa; Chiarugi, Paola (2022). Lactate rewires lipid metabolism and sustains a metabolic-epigenetic axis in prostate cancer. CANCER RESEARCH, pp. canres.0914.2021-canres.0914.2021, ISSN:0008-5472 DOI

Iozzo M.; Sgrignani G.; Comito G.; Chiarugi P.; Giannoni E. (2021). Endocannabinoid system and tumour microenvironment: New intertwined connections for anticancer approaches. CELLS, vol. 10, pp. 3396-3430, ISSN:2073-4409 DOI

Lorito, Nicla; Bacci, Marina; Smiriglia, Alfredo; Mannelli, Michele; Parri, Matteo; Comito, Giuseppina; Ippolito, Luigi; Giannoni, Elisa; Bonechi, Martina; Benelli, Matteo; Migliaccio, Ilenia; Malorni, Luca; Chiarugi, Paola; Morandi, Andrea (2020). Glucose Metabolic Reprogramming of ER Breast Cancer in Acquired Resistance to the CDK4/6 Inhibitor Palbociclib. CELLS, vol. 9, pp. 0-0, ISSN:2073-4409 DOI

Pietrovito L.; Iozzo M.; Bacci M.; Giannoni E.; Chiarugi P. (2020). Treatment with Cannabinoids as a Promising Approach for Impairing Fibroblast Activation and Prostate Cancer Progression. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, pp. 787-803, ISSN:1422-0067 DOI

Ippolito L.; Giannoni E.; Chiarugi P.; Parri M. (2020). Mitochondrial Redox Hubs as Promising Targets for Anticancer Therapy. FRONTIERS IN ONCOLOGY, vol. 10, pp. 256-268, ISSN:2234-943X DOI

BACCI M, IPPOLITO L, MAGNELLI L, GIANNONI E, CHIARUGI P (2019). Stromal-induced mitochondrial re-education: Impact on epithelial-to-mesenchymal transition and cancer aggressiveness.. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, vol. xx, pp. 0-0, ISSN:1084-9521 DOI Accesso ONLINE all'editore

Comito, G.; Iscaro, A.; Bacci, M.; Morandi, A.; Ippolito, L.; Parri, M.; Montagnani, I.; Raspollini, M.R.; Serni, S.; Simeoni, L.; Giannoni, E.*; Chiarugi, P. (2019). Lactate modulates CD4 + T-cell polarization and induces an immunosuppressive environment, which sustains prostate carcinoma progression via TLR8/miR21 axis. ONCOGENE, vol. 38 (19), pp. 3681-3695, ISSN:0950-9232, Nature Publishing Group: DOI Accesso ONLINE all'editore

Ippolito, Luigi; Morandi, Andrea; Taddei, Maria Letizia; Parri, Matteo; Comito, Giuseppina; Iscaro, Alessandra; Raspollini, Maria Rosaria; Magherini, Francesca; Rapizzi, Elena; Masquelier, Julien; Muccioli, Giulio G; Sonveaux, Pierre; Chiarugi, Paola; Giannoni, Elisa (2019). Cancer-associated fibroblasts promote prostate cancer malignancy via metabolic rewiring and mitochondrial transfer. ONCOGENE, vol. 38, pp. 5339-5355, ISSN:0950-9232 DOI Accesso ONLINE all'editore

Bacci M.; Lorito N.; Ippolito L.; Ramazzotti M.; Luti S.; Romagnoli S.; Parri M.; Bianchini F.; Cappellesso F.; Virga F.; Gao Q.; Simoes B.M.; Marangoni E.; Martin L.-A.; Comito G.; Ferracin M.; Giannoni E.; Mazzone M.; Chiarugi P.; Morandi A. (2019). Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer. CELL REPORTS, vol. 28, pp. 104-118.e8, ISSN:2211-1247 DOI Accesso ONLINE all'editore

Pietrovito L, Comito G, Parri M, Giannoni E, Chiarugi P, Taddei ML. (2019). Zoledronic Acid Inhibits the RhoA-mediated Amoeboid Motility of Prostate Cancer Cells.. CURRENT CANCER DRUG TARGETS, vol. 19, pp. 807-816, ISSN:1873-5576 DOI

Ippolito, Luigi; Morandi, Andrea; Giannoni, Elisa; Chiarugi, Paola (2018). Lactate: A Metabolic Driver in the Tumour Landscape. TRENDS IN BIOCHEMICAL SCIENCES, pp. 153-166, ISSN:0968-0004 DOI

Taddei, Maria Letizia*; Cavallini, Lorenzo; Ramazzotti, Matteo; Comito, Giuseppina; Pietrovito, Laura; Morandi, Andrea; Giannoni, Elisa; Raugei, Giovanni; Chiarugi, Paola (2018). Stromal-induced downregulation of miR-1247 promotes prostate cancer malignancy. JOURNAL OF CELLULAR PHYSIOLOGY, vol. 6, pp. 8274-8285, ISSN:0021-9541 DOI Accesso ONLINE all'editore

Apicella, Maria; Giannoni, Elisa; Fiore, Stephany; Ferrari, Karin Johanna; Fernández-Pérez, Daniel; Isella, Claudio; Granchi, Carlotta; Minutolo, Filippo; Sottile, Antonino; Comoglio, Paolo Maria; Medico, Enzo; Pietrantonio, Filippo; Volante, Marco; Pasini, Diego; Chiarugi, Paola; Giordano, Silvia; Corso, Simona (2018). Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies. CELL METABOLISM, vol. 28, pp. 848-865.e6-865.e6, ISSN:1550-4131 DOI

Morandi, Andrea; Taddei, Maria Letizia; Chiarugi, Paola; Giannoni, Elisa (2017). Targeting the Metabolic Reprogramming That Controls Epithelial-to-Mesenchymal Transition in Aggressive Tumors. FRONTIERS IN ONCOLOGY, vol. 7:40, pp. 1-19, ISSN:2234-943X DOI Accesso ONLINE all'editore

Pistore C, Giannoni E, Colangelo T, Rizzo F, Magnani E, Muccillo L, Giurato G, Mancini M, Rizzo S, Riccardi M, Sahnane N, Del Vescovo V, Kishore K, Mandruzzato M, Macchi F, Pelizzola M, Denti MA, Furlan D, Weisz A, Colantuoni V, Chiarugi P, Bonapace IM (2017). DNA methylation variations are required for epithelial-to-mesenchymal transition induced by cancer-associated fibroblasts in prostate cancer cells.. ONCOGENE, vol. 36, pp. 5551-5566, ISSN:1476-5594 DOI Accesso ONLINE all'editore

Calvani, M; Bianchini, F; Taddei, Ml; Becatti, M; Giannoni, E; Chiarugi, P; Calorini, L1. (2016). Etoposide-Bevacizumab a new strategy against human melanoma cells expressing stem-like traits. ONCOTARGET, vol. 7(33), pp. 51138-51149, ISSN:1949-2553 DOI Accesso ONLINE all'editore

Comito, G; Segura, Cp; Taddei, Ml; Lanciotti, M; Serni, S; Morandi, A; Chiarugi, P; Giannoni, E (2016). Zoledronic acid impairs stromal reactivity by inhibiting M2-macrophages polarization and prostate cancer-associated fibroblasts.. ONCOTARGET, vol. ..8, pp. 118-132, ISSN:1949-2553 DOI Accesso ONLINE all'editore

Morandi, A; Giannoni, E.; Chiarugi, P (2016). Nutrient Exploitation within the Tumor–Stroma Metabolic Crosstalk. TRENDS IN CANCER, vol. 2, pp. 736-746, ISSN:2405-8033 DOI Accesso ONLINE all'editore

Peppicelli, Silvia; Toti, Alessandra; Giannoni, Elisa; Bianchini, Francesca; Margheri, Francesca; Del Rosso, Mario; Calorini, Lido (2016). Metformin is also effective on lactic acidosis-exposed melanoma cells switched to oxidative phosphorylation. CELL CYCLE, vol. 15, pp. 1908-1918, ISSN:1538-4101 DOI

Ippolito, Luigi; Marini, Alberto; Cavallini, Lorenzo; Morandi, Andrea; Pietrovito, Laura; Pintus, Gianfranco; Giannoni, Elisa; Schrader, Thomas; Puhr, Martin; Chiarugi, Paola; Taddei, Maria Letizia (2016). Metabolic shift toward oxidative phosphorylation in docetaxel resistant prostate cancer cells.. ONCOTARGET, vol. 7, pp. 61890-61904, ISSN:1949-2553 DOI Accesso ONLINE all'editore

Bacci, M; Giannoni, E; Fearns, A; Ribas, R; Gao, Q; Taddei, Ml; Pintus, G; Dowsett, M; Isacke, Cm; Martin, La; Chiarugi, P; Morandi, A (2016). miR-155 Drives Metabolic Reprogramming of ER+ Breast Cancer Cells Following Long-Term Estrogen Deprivation and Predicts Clinical Response to Aromatase Inhibitors.. CANCER RESEARCH, vol. 76(6), pp. 1615-1626, ISSN:0008-5472 DOI Accesso ONLINE all'editore

Fedeli, S.; Brandi, A.; Venturini, L.; Chiarugi, P.; Giannoni, E.; Paoli, P.; Corti, D.; Giambastiani, G.; Tuci, G.; Cicchi, S. (2016). The ”click-on-tube” approach for the production of efficient drug carriers based on oxidize multiwalled carbon nanotubes. JOURNAL OF MATERIALS CHEMISTRY. B, vol. 4, pp. 3823-3831, ISSN:2050-7518 DOI Accesso ONLINE all'editore

Rapizzi, Elena; Fucci, Rossella; Giannoni, Elisa; Canu, Letizia; Richter, Susan; Cirri, Paolo; Mannelli, Massimo (2015). Role of microenvironment on neuroblastoma SK-N-AS SDHB-silenced cell metabolism and function. ENDOCRINE-RELATED CANCER, vol. 22, pp. 409-417, ISSN:1351-0088 DOI Accesso ONLINE all'editore

Denise, Corti; Paolo, Paoli; Maura, Calvani; Maria Letizia, Taddei; Elisa, Giannoni; Scott, Kopetz; Syed Mohammad Ali, Kazmi; Maria Pia, Morelli; Piergiorgio, Pettazzoni; Elena, Sacco; Anna, Caselli; Marco, Vanoni; Matteo, Landriscina; Paolo, Cirri; Paola, Chiarugi. (2015). 5-Fluorouracil resistant colon cancer cells are addicted to OXPHOS to survive and enhance stem-like trait. ONCOTARGET, vol. 6, pp. 41706-41721, ISSN:1949-2553 DOI Accesso ONLINE all'editore

Maraldi, T; Angeloni, C; Giannoni, E; Sell, C. (2015). Reactive Oxygen Species in stem cells.. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, pp. 0-0, ISSN:1942-0994 DOI

Giannoni, E; Taddei, Ml; Morandi, A; Comito, G; Calvani, M; Bianchini, F; Richichi, B; Raugei, G; Wong, N; Tang, D; Chiarugi, P. (2015). Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs OXPHOS and prostate cancer metastatic spread. ONCOTARGET, vol. 6(27), pp. 24061-24074, ISSN:1949-2553 DOI Accesso ONLINE all'editore

Calvani M, Pelon F, Comito G, Taddei ML, Moretti S, Innocenti S, Nassini R, Gerlini S, Borgognoni, Bambi F, Giannoni E, Filippi L, Chiarugi P. (2015). Norepinephrine promotes tumor microenvironment reactivity through β3-adrenoreceptors during melanoma progression.. ONCOTARGET, vol. 6, pp. 4615-4632, ISSN:1949-2553 DOI Accesso ONLINE all'editore

Doldi, V; Callari, M; Giannoni, E; D'Aiuto, F; Maffezzini, M; Valdagni, R; Chiarugi, P; Gandellini, P; Zaffaroni, N. (2015). Integrated gene and miRNA expression analysis of prostate cancer associated fibroblasts supports a prominent role for interleukin-6 in fibroblast activation.. ONCOTARGET, vol. 6(31), pp. 31441-31460, ISSN:1949-2553 DOI

Margheri F; Luciani C; Taddei ML; Giannoni E; Laurenzana A; Biagioni A; Chillà A; Chiarugi P; Fibbi G; Del Rosso M (2014). The receptor for urokinase-plasminogen activator (uPAR) controls plasticity of cancer cell movement in mesenchymal and amoeboid migration style.. ONCOTARGET, vol. 5(6), pp. 1538-1553, ISSN:1949-2553

Lanciotti M; Masieri L; Raspollini MR; Minervini A; Mari A; Comito G; Giannoni E; Carini M; Chiarugi P; Serni S (2014). The role of M1 and M2 macrophages in prostate cancer in relation to extracapsular tumor extension and biochemical recurrence after radical prostatectomy. BIOMED RESEARCH INTERNATIONAL, vol. 3, pp. 20-31, ISSN:2314-6133 DOI

Giannoni E; Chiarugi P. (2014). Redox Circuitries Driving Src Regulation.. ANTIOXIDANTS & REDOX SIGNALING, vol. 20(13), pp. 2011-2025, ISSN:1523-0864

Rapizzi E; Ercolino T; Fucci R; Zampetti B; Felici R; Guasti D; Morandi A; Giannoni E; Giaché V; Bani D; Chiarugi A; Mannelli M (2014). Succinate dehydrogenase subunit B mutations modify human neuroblastoma cell metabolism and proliferation. HORMONES & CANCER, vol. 5(3), pp. 174-184, ISSN:1868-8497

Taddei ML; Giannoni E; Morandi A; Ippolito L; Ramazzotti M; Callari M; Gandellini P; Chiarugi P (2014). Mesenchymal to amoeboid transition is associated with stem-like features of melanoma cells. CELL COMMUNICATION AND SIGNALING, vol. 24, pp. 1-12, ISSN:1478-811X DOI

Taddei ML; Cavallini L; Comito G; Giannoni E; Folini M; Marini A; Gandellini P; Morandi A; Pintus G; Raspollini MR; Zaffaroni N; Chiarugi P. (2014). Senescent stroma promotes prostate cancer progression: The role of miR-210. MOLECULAR ONCOLOGY, pp. 1729-1746, ISSN:1574-7891 DOI

Comito G; Giannoni E; Segura CP; Barcellos-de-Souza P; Raspollini MR; Baroni G; Lanciotti M; Serni S; Chiarugi P. (2014). Cancer-associated fibroblasts and M2-polarized macrophages synergize during prostate carcinoma progression.. ONCOGENE, vol. 33(19), pp. 2423-2431, ISSN:0950-9232 DOI

Gandellini P; Giannoni E; Casamichele A; Taddei ML; Callari M; Piovan C; Valdagni R; Pierotti MA; Zaffaroni N; Chiarugi P. (2014). miR-205 Hinders the Malignant Interplay Between Prostate Cancer Cells and Associated Fibroblasts. ANTIOXIDANTS & REDOX SIGNALING, vol. 20(7), pp. 1045-1059, ISSN:1523-0864

Taddei ML; Giannoni E; Comito G; Chiarugi P. (2013). Microenvironment and tumor cell plasticity: An easy way out.. CANCER LETTERS, pp. ?-?, ISSN:0304-3835

Paoli P; Giannoni E; Chiarugi P. (2013). Anoikis molecular pathways and its role in cancer progression.. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, vol. 1833, pp. 3481-3498, ISSN:0167-4889 DOI Accesso ONLINE all'editore

Tania Fiaschi;Elisa Giannoni;Maria Letizia Taddei;Paolo Cirri;Alberto Marini;Gianfranco Pintus;Cristina Nativi;Barbara Richichi;Andrea Scozzafava;Fabrizio Carta;Eugenio Torre;Claudiu T. Supuran;Paola Chiarugi (2013). Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells. CELL CYCLE, vol. 12, pp. 1791-1801, ISSN:1538-4101 DOI

Pitozzi, Vanessa; Mocali, Alessandra; Laurenzana, Anna; Giannoni, Elisa; Cifola, I.; Battaglia, C.; Chiarugi, Paola; Dolara, Piero; Giovannelli, Lisa (2013). Chronic Resveratrol Treatment Ameliorates Cell Adhesion and Mitigates the Inflammatory Phenotype in Senescent Human Fibroblasts. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, vol. 68, pp. 371-381, ISSN:1079-5006 DOI

S. Serratì; A. Chillà; A. Laurenzana; F. Margheri; E. Giannoni; L. Magnelli; P. Chiarugi ; J. Dotor; E. Feijoo; L. Bazzichi; S. Bombardieri; B. Kahaleh; G. Fibbi; M. Del Rosso (2013). Systemic sclerosis endothelial cells recruit and activate dermal fibroblasts by induction of a CTGF(CCN2)/TGF-beta-dependent mesechymal-to mesenchymal transition. ARTHRITIS AND RHEUMATISM, vol. 65(1), pp. 258-269, ISSN:1529-0131 DOI

Giannoni E; Taddei ML; Parri M; Bianchini F; Santosuosso M; Grifantini R; Fibbi G; Mazzanti B; Calorini L; Chiarugi P. (2013). EphA2-mediated mesenchymal-amoeboid transition induced by endothelial progenitor cells enhances metastatic spread due to cancer-associated fibroblasts.. JOURNAL OF MOLECULAR MEDICINE, vol. 91(1), pp. 103-115, ISSN:0946-2716

ML.Taddei; E.Giannoni; T. Fiaschi; P.Chiarugi (2012). Anoikis: an emerging hallmark in health and diseases.. JOURNAL OF PATHOLOGY, vol. 226, pp. 380-393, ISSN:0022-3417 DOI

Bianchini F; Giannoni E; Serni S; Chiarugi P; Calorini L. (2012). 22 : 6n-3 DHA inhibits differentiation of prostate fibroblasts into myofibroblasts and tumorigenesis.. BRITISH JOURNAL OF NUTRITION, vol. 108, pp. 2129-2137, ISSN:1475-2662 DOI

Fiaschi T; Giannoni E; Taddei ML; Chiarugi P (2012). Globular adiponectin activates motility and regenerative traits of muscle satellite cells.. PLOS ONE, vol. 7, pp. -----, ISSN:1932-6203

Fiaschi T; Marini A; Giannoni E; Taddei ML; Gandellini P; De Donatis A; Lanciotti M; Serni S; Cirri P; Chiarugi P. (2012). RECIPROCAL METABOLIC REPROGRAMMING THROUGH LACTATE SHUTTLE COORDINATELY INFLUENCES TUMOR-STROMA INTERPLAY.. CANCER RESEARCH, vol. 72, pp. 5130-5140, ISSN:0008-5472

Maria Letizia Taddei, Elisa Giannoni, Giovanni Raugei, Salvatore Scacco, AnnaMaria Sardanelli, Sergio Papa, Paola Chiarugi (2012). Mitochondrial oxidative stress due to complex I dysfunction promotes fibroblast activation and melanoma cell invasiveness. JOURNAL OF SIGNAL TRANSDUCTION (ONLINE), pp. 0-0, ISSN:2090-1747 DOI

Giannoni E; Parri M; Chiarugi P (2012). EMT and Oxidative Stress: A Bidirectional Interplay Affecting Tumor Malignancy. ANTIOXIDANTS & REDOX SIGNALING, vol. ---, pp. ---, ISSN:1523-0864

Comito G; Giannoni E; Gennaro PD; Segura CP; Gerlini G; Chiarugi P. (2012). Stromal fibroblasts synergize with hypoxic oxidative stress to enhance melanoma aggressiveness.. CANCER LETTERS, vol. ----, pp. ----------, ISSN:0304-3835

Maria Letizia Taddei; Elisa Giannoni; Giovanni Raugei; Salvatore Scacco; Anna Maria Sardanelli; Sergio Papa; Paola Chiarugi (2012). Mitochondrial Oxidative Stress due to Complex I Dysfunction Promotes Fibroblast Activation and Melanoma Cell Invasiveness. JOURNAL OF SIGNAL TRANSDUCTION (ONLINE), vol. 2012, pp. 1-10, ISSN:2090-1747 DOI

Calvani M; Comito G; Giannoni E; Chiarugi P. (2012). Time-dependent stabilization of hypoxia inducible factor-1α by different intracellular sources of reactive oxygen species.. PLOS ONE, vol. 7(10), pp. 1-11, ISSN:1932-6203

Taddei ML; Parri M; Angelucci A; Bianchini F; Marconi C; Giannoni E; Raugei G; Bologna M; Calorini L; Chiarugi P (2011). EphA2 induces metastatic growth regulating amoeboid motility and clonogenic potential in prostate carcinoma cells. MOLECULAR CANCER RESEARCH, vol. 9(2), pp. 149-160, ISSN:1541-7786

G. Comito; M. Calvani; E. Giannoni; F. Bianchini; L. Calorini; E. Torre; C. Migliore; S. Giordano; P. Chiarugi (2011). HIF-1α stabilization by mitochondrial ROS promotes Met-dependent invasive growth and vasculogenic mimicry in melanoma cells.. FREE RADICAL BIOLOGY & MEDICINE, vol. 51(4), pp. 893-904, ISSN:0891-5849 DOI

E. Giannoni; F. Bianchini; L. Calorini; P. Chiarugi (2011). Cancer associated fibroblasts exploit reactive oxygen species through a proinflammatory signature leading to epithelial mesenchymal transition and stemness.. ANTIOXIDANTS & REDOX SIGNALING, vol. 14(12), pp. 2361-2371, ISSN:1523-0864

Giannoni E; Taddei ML; Chiarugi P. (2010). SRC redox regulation: Again in the frontline.. FREE RADICAL BIOLOGY & MEDICINE, vol. 49, pp. 516-527, ISSN:0891-5849

E. Giannoni; F. Bianchini; L. Masieri;S. Serni; E. Torre; L. Calorini; P. Chiarugi (2010). Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness.. CANCER RESEARCH, vol. 70(17), pp. 6945-6956, ISSN:0008-5472 DOI

Fiaschi T; Tedesco FS; Giannoni E; Diaz-Manera J; Parri M; Cossu G; Chiarugi P. (2010). Globular adiponectin as a complete mesoangioblast regulator: role in proliferation, survival, motility, and skeletal muscle differentiation.. MOLECULAR BIOLOGY OF THE CELL, vol. 21, pp. 848-859, ISSN:1059-1524

ML.Taddei; M.Parri; A.Angelucci; B.Onnis; F.Bianchini; E.Giannoni; G.Raugei; L.Calorini; N.Rucci; A.Teti; M.Bologna; P.Chiarugi. (2009). Kinase-dependent and -independent roles of EphA2 in the regulation of prostate cancer invasion and metastasis. THE AMERICAN JOURNAL OF PATHOLOGY, vol. 174, pp. 1492-1503, ISSN:0002-9440

Pani G.; Giannoni E.; Galeotti T.; Chiarugi P. (2009). Redox-based escape mechanism from death: the cancer lesson.. ANTIOXIDANTS & REDOX SIGNALING, vol. 11, pp. 2791-2806, ISSN:1523-0864

Giannoni E.; Fiaschi T.; Ramponi G.; Chiarugi P. (2009). Redox regulation of anoikis resistance of metastatic prostate cancer cells: key role for Src and EGFR-mediated pro-survival signals.. ONCOGENE, vol. 28, pp. 2074-2086, ISSN:0950-9232

P. Chiarugi; E. Giannoni (2008). Anoikis: A necessary death program for anchorage-dependent cells.. BIOCHEMICAL PHARMACOLOGY, vol. 76(11), pp. 1352-1364, ISSN:0006-2952

E. Giannoni; F. Buricchi; G. Grimaldi; M. Parri; F. Cialdai; L. Taddei; G. Raugei; G. Ramponi; P. Chiarugi (2008). Redox regulation of anoikis: reactive oxygen species as essential mediators of cell survival.. CELL DEATH AND DIFFERENTIATION, vol. 15(5), pp. 867-878, ISSN:1350-9047

M. PARRI; F. BURICCHI; E. GIANNONI; G. GRIMALDI; T. MELLO; G. RAUGEI; G. RAMPONI; P. CHIARUGI (2007). EphrinA1 activates a Src/focal adhesion kinase-mediated motility response leading to rho-dependent actino/myosin contractility. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 282(27), pp. 19619-19628, ISSN:0021-9258, American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824:

F. Buricchi; E. Giannoni; G. Grimaldi; M. Parri; G. Raugei; G. Ramponi; P. Chiarugi (2007). Redox regulation of ephrin/integrin cross-talk. CELL ADHESION & MIGRATION, vol. 1, pp. 33-42, ISSN:1933-6918

S. Catarzi; E. Giannoni; F. Favilli; E. Meacci; T. Iantomasi; MT. Vincenzini (2007). Sphingosine 1-phosphate stimulation of NADPH oxidase activity: relationship with platelet-derived growth factor receptor and c-Src kinase. BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1770, pp. 872-883, ISSN:0006-3002 DOI

E. GIANNONI; G. RAUGEI; P. CHIARUGI; G. RAMPONI (2006). A novel redox-based switch: LMW-PTP oxidation enhances Grb2 binding and leads to ERK activation.. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 348(2), pp. 367-373, ISSN:0006-291X

S.CATARZI; C.BIAGIONI; E.GIANNONI; F.FAVILLI; T.MARCUCCI; T.IANTOMASI; MT.VINCENZINI (2005). Redox regulation of Platelet-Derived-Growth-Factor-Receptor: role of NADPH-oxidase and c-Src tyrosine kinase. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, vol. 1745, pp. 166-175, ISSN:0167-4889 DOI

P. CIRRI; M. TADDEI; P. CHIARUGI; F. BURICCHI; A. CASELLI; P. PAOLI; E. GIANNONI; G. CAMICI; G. MANAO; G. RAUGEI; G. RAMPONI (2005). INSULIN INHIBITS PLATELET-DERIVED GROWTH FACTOR-INDUCED CELL PROLIFERATION. MOLECULAR BIOLOGY OF THE CELL, vol. 16, pp. 73-83, ISSN:1059-1524 DOI

P. Chiarugi; E. Giannoni (2005). Anchorage-dependent cell growth: tyrosine kinases and phosphatases meet redox regulation.. ANTIOXIDANTS & REDOX SIGNALING, vol. 7(5-6), pp. 578-592, ISSN:1523-0864

E. GIANNONI; F. BURICCHI; G. RAUGEI; G. RAMPONI; P. CHIARUGI (2005). Intracellular reactive oxygen species activate Src tyrosine kinase during cell adhesion and anchorage-dependent cell growth.. MOLECULAR AND CELLULAR BIOLOGY, vol. 25(15), pp. 6391-6403, ISSN:0270-7306, American Society for Microbiology / DC:1752 N Street Northwest:Washington, DC 20036:(202)737-3600, EMAIL: jadelman@asmusa.org, INTERNET: http://www.asmusa.org/asm.htm, Fax: (202)942-9342:

M. PARRI; F. BURICCHI; L. TADDEI; E. GIANNONI; G. RAUGEI; G. RAMPONI; P. CHIARUGI (2005). EphrinA1 repulsive response is regulated by an EphA2 tyrosine phosphatase. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 280(40), pp. 34008-34018, ISSN:0021-9258, American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824:

F. BURICCHI; P. CHIARUGI; T. FIASCHI; E. GIANNONI; L. MAGNELLI; E. FANTI; G. RAUGEI; G. RAMPONI (2005). DURING MUSCLE AGEING THE ACTIVATION OF THE MITOGENIC SIGNALLING IS NOT SUFFICIENT TO GUARANTEE CELLULAR DUPLICATION.. ITALIAN JOURNAL OF BIOCHEMISTRY, vol. 54, pp. 458-467, ISSN:0021-2938

S. VENTURA, J. ZURDO, S. NARAYANAN, M. PARRENO, R. MANGUES, B. REIF, F. CHITI; E. GIANNONI, C.M. DOBSON, F.X. AVILES, L. SERRANO (2004). Short amino acid stretches can mediate amyloid formation in globular proteins: the Src homology 3 (SH3) case.. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 101, pp. 7258-7263, ISSN:0027-8424 DOI

P. CHIARUGI; ML. TADDEI; N. SCHIAVONE; L. PAPUCCI; E. GIANNONI; T FIASCHI; S. CAPACCIOLI; G. RAUGEI; G. RAMPONI (2004). LMW-PTP is a positive regulator of tumor onset and growth. ONCOGENE, vol. 23, pp. 3905-3914, ISSN:0950-9232 DOI Accesso ONLINE all'editore

C. CECCHI; G. LIGURI ;C. FIORILLO ; F. BOGANI ; M. GAMBASSI ; E. GIANNONI; P. CIRRI ; S. BAGLIONI S; G. RAMPONI (2004). Acylphosphatase overexpression triggers SH-SY5Y differentiation towards neuronal phenotype.. CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 61, pp. 1775-1784, ISSN:1420-682X

T. FIASCHI; P. CHIARUGI; F. BURICCHI; E. GIANNONI; L. TADDEI; L. MAGNELLI; G. COZZI; G. RAUGEI; G. RAMPONI (2003). Down-regulation of platelet-derived growth factor receptor signaling during myogenesis.. CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 60(12), pp. 2721-2735, ISSN:1420-682X DOI Accesso ONLINE all'editore

P. Paoli; L. Pazzagli; E. Giannoni; A. Caselli; G. Manao; G. Camici; G. Ramponi (2003). A nucleophilic catalysis step is involved in the hydrolysis of aryl phosphate monoesters by human CT acylphosphatase. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, pp. 194-199, ISSN:0021-9258 DOI Accesso ONLINE all'editore

T.IANTOMASI; F.FAVILLI; S.CATARZI; E.GIANNONI; C.BIAGIONI; MT.VINCENZINI (2003). Involvement of tyrosine phosphorylation on GSH transport in NIH3T3 fibroblasts. IUBMB LIFE, vol. 55, pp. 159-165, ISSN:1521-6543 DOI

P. CHIARUGI; G. PANI; E. GIANNONI; L. TADDEI; R. COLAVITTI; G. RAUGEI; M. SYMONS; S. BORRELLO; T. GALEOTTI; G. RAMPONI (2003). Reactive oxygen species as essential mediators of cell adhesion: the oxidative inhibition of a FAK tyrosine phosphatase is required for cell adhesion.. THE JOURNAL OF CELL BIOLOGY, vol. 161(5), pp. 933-944, ISSN:0021-9525

E. GIANNONI; P. CHIARUGI; G. COZZI; L. MAGNELLI; L. TADDEI; T. FIASCHI; F. BURICCHI; G. RAUGEI; G. RAMPONI (2003). Lymphocyte function-associated antigen-1-mediated T cell adhesion is impaired by low molecular weight phosphotyrosine phosphatase-dependent inhibition of FAK activity. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278(38), pp. 36763-36776, ISSN:0021-9258 DOI Accesso ONLINE all'editore

ML. TADDEI ; P. CHIARUGI ; P. CIRRI; F. BURICCHI ; T. FIASCHI ; E. GIANNONI ; D. TALINI ; G. COZZI ; L. FORMIGLI ; G. RAUGEI ; G. RAMPONI (2002). Beta-catenin interacts with low-molecular-weight protein tyrosine phosphatase leading to cadherin-mediated cell-cell adhesion increase.. CANCER RESEARCH, vol. 62, pp. 6489-6499, ISSN:0008-5472

P. CHIARUGI; P. CIRRI; M. TADDEI; D. TALINI; F. BURICCHI; E. GIANNONI; G. CAMICI; G. RAUGEI; G. RAMPONI; L. DORIA; T. FIASCHI (2002). New perspectives in PDGF receptor downregulation: the main role of phosphotyrosine phosphatases. JOURNAL OF CELL SCIENCE, vol. 115, pp. 2219-2232, ISSN:0021-9533 Accesso ONLINE all'editore

M. BUCCIANTINI; E. GIANNONI; F. CHITI; F. BARONI; L. FORMIGLI; J. ZURDO; N. TADDEI; G. RAMPONI; C. DOBSON; M. STEFANI (2002). Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases. NATURE, vol. 416(6880), pp. 507-511, ISSN:0028-0836, Nature America Incorporated:345 Park Avenue South, 6th Floor:New York, NY 10010:(888)331-6288, EMAIL: institutions@natureny.com, INTERNET: http://www.nature.com, Fax: (212)689-9108: DOI

P. Chiarugi; P. Cirri; ML. Taddei.; E. Giannoni; T. Fiaschi; F. Buricchi; G. Camici; G. Raugei; G. Ramponi (2002). Insight into the role of low molecular weight phosphotyrosine phosphatase (LMW-PTP) on platelet-derived growth factor receptor (PDGF-r) signaling. LMW-PTP controls PDGF-r kinase activity through TYR-857 dephosphorylation. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, pp. 37331-37338, ISSN:0021-9258 DOI Accesso ONLINE all'editore

P. PAOLI; E. GIANNONI; R. PESCITELLI; G. CAMICI; G. MANAO; G. RAMPONI. (2001). HYDROGEN PEROXIDE TRIGGERS THE FORMATION OF A DISULFIDE DIMER OF MUSCLE ACYLPHOSPHATASE AND MODIFIES SOME FUNCTIONAL PROPERTIES OF THE ENZYME. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, pp. 41862-41869, ISSN:0021-9258 DOI Accesso ONLINE all'editore

P. CHIARUGI; T. FIASCHI; L. TADDEI; D. TALINI; E. GIANNONI; G. RAUGEI; G. RAMPONI (2001). Two vicinal cysteines confer a peculiar redox regulation to low molecular weight protein tyrosine phosphatase in response to platelet-derived growth factor receptor stimulation.. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276(36), pp. 33478-33487, ISSN:0021-9258

T. FIASCHI; P. CHIARUGI; F. BURICCHI; E. GIANNONI; L. TADDEI; D. TALINI; G. COZZI; S. ZECCHI; G. RAUGEI; G. RAMPONI (2001). Low molecular weight protein-tyrosine phosphatase is involved in growth inhibition during cell differentiation.. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276(52), pp. 49156-49163, ISSN:0021-9258

P. Paoli; G. Camici; G. Manao; E. Giannoni; G. Ramponi (2000). Acylphosphatase possesses nucleoside triphosphatase and nucleoside diphosphatase activities. BIOCHEMICAL JOURNAL, vol. 349, pp. 43-49, ISSN:0264-6021 Accesso ONLINE all'editore

P. CHIARUGI; P. CIRRI; M. TADDEI; E. GIANNONI; G. CAMICI; G. MANAO; G. RAUGEI; G. RAMPONI (2000). The low M(r) protein-tyrosine phosphatase is involved in Rho-mediated cytoskeleton rearrangement after integrin and platelet-derived growth factor stimulation.. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, pp. 4640-4646, ISSN:0021-9258 Accesso ONLINE all'editore

E. Giannoni; P. Cirri; P. Paoli; T. Fiaschi; G. Camici; G. Manao; G. Raugei; G. Ramponi (2000). Acylphosphatase Is a Strong Apoptosis Inducer in HeLa Cell Line. MOLECULAR CELL BIOLOGY RESEARCH COMMUNICATIONS, vol. 3, pp. 264-270, ISSN:1522-4724 DOI Accesso ONLINE all'editore

F. CHITI; N. TADDEI; E. GIANNONI; N. VAN NULAND; G. RAMPONI; C. DOBSON (1999). Development of enzymatic activity during protein folding. Detection of a spectroscopically silent native-like intermediate of muscle acylphosphatase.. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274(29), pp. 20151-20158, ISSN:0021-9258, American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824:

F. Magherini; E. Giannoni;G. Raugei; P. Cirri; P. Paoli; A. Modesti; G. Camici; G. Ramponi (1998). Cloning of murine low molecular weight phosphotyrosine protein phosphatase cDNA: identification of a new isoform. FEBS LETTERS, vol. 437, pp. 263-266, ISSN:0014-5793 Accesso ONLINE all'editore

Elisa GIANNONI

Biography