Micheli, Laura; Balayssac, David; Busserolles, Jérôme; Dalbos, Cristelle; Prival, Laetitia; Richard, Damien; Quintana, Mercedes; Di Cesare Mannelli, Lorenzo; Toti, Alessandra; Ciampi, Clara; Ghelardini, Carla; Vlasakova, Katerina; Glaab, Warren E.; Hu, Yang; Loryan, Irena; Perrault, Olivier; Slaoui, Mohamed; Wuersch, Kuno; Johnson, Eric; Frieauff, Wilfried; Penraat, Kelley; Brees, Dominique; Dubost, Valérie; Theil, Diethilde (2025). The challenge to identify sensitive safety biomarkers of peripheral neurotoxicity in the rat: A collaborative effort across industry and academia (IMI NeuroDeRisk project). TOXICOLOGY, vol. 510, pp. 0-0, ISSN:0300-483X DOI  

  Micheli Laura, Vasarri Marzia, Degl'Innocenti Donatella , Di Cesare Mannelli Lorenzo, Ghelardini Carla , Emiliano Antiga, Verdelli Alice , Caproni Marzia, Barletta Emanuela (2024). Posidonia oceanica (L.) Delile Is a Promising Marine Source Able to Alleviate Imiquimod-Induced Psoriatic Skin Inflammation. MARINE DRUGS, vol. 22, pp. 0-0, ISSN:1660-3397 DOI   Accesso ONLINE all'editore

  Micheli, Laura; Muraglia, Marilena; Corbo, Filomena; Venturi, Daniel; Clodoveo, Maria Lisa; Tardugno, Roberta; Santoro, Valentina; Piccinelli, Anna Lisa; Di Cesare Mannelli, Lorenzo; Nobili, Stefania; Ghelardini, Carla (2024). The Unripe Carob Extract (Ceratonia siliqua L.) as a Potential Therapeutic Strategy to Fight Oxaliplatin-Induced Neuropathy. NUTRIENTS, vol. 17, pp. 0-0, ISSN:2072-6643 DOI  

  Micheli, Laura; Toti, Alessandra; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Crocetti, Letizia; Farina, Carlo; Scherz, Michael (2024). Synthesis and Anti‐Hyperalgesic Efficacy of MP‐103, a Non‐Racemic Enantiomeric Mixture of a New 1,4‐Diazabicyclo[4.3.0]nonan‐9‐one. CHEMISTRYSELECT, vol. 9, pp. 0-0, ISSN:2365-6549 DOI  

  Margiotta, Francesco; Di Cesare Mannelli, Lorenzo; Morabito, Antonino; Ghelardini, Carla; Lucarini, Elena (2024). Investigating epithelial-neuronal signaling contribution in visceral pain through colon organoid-dorsal root ganglion neuron co-cultures. NEURAL REGENERATION RESEARCH, vol. 19, pp. 1199-1200, ISSN:1673-5374 DOI  

  Hugo R. Arias, Laura Micheli, Deborah Rudin, Ophelie Bento, Saskia Borsdorf, Clara Campi, Philippe Marin, Evgeni Ponimaskin, Dina Manetti, Maria Novella Romanelli, Carla Ghelardini, Matthias E. Liechti, Lorenzo Di Cesare Mannelli (2024). Non-hallucinogenic compounds derived from iboga alkaloids alleviate neruopathic and visceral pain in mice through a mechanism involving 5-HT2A receptor activation. BIOMEDICINE & PHARMACOTHERAPY, vol. 177, pp. 1-14, ISSN:1950-6007 DOI  

  Libero, Maria Loreta; Lucarini, Elena; Recinella, Lucia; Ciampi, Clara; Veschi, Serena; Piro, Anna; Chiavaroli, Annalisa; Acquaviva, Alessandra; Nilofar, Nilofar; Orlando, Giustino; Generali, Daniele; Ghelardini, Carla; di Cesare Mannelli, Lorenzo; Montero‐Hidalgo, Antonio J.; Luque, Raúl M.; Ferrante, Claudio; Menghini, Luigi; di Simone, Simonetta Cristina; Brunetti, Luigi; Leone, Sheila (2024). Anti‐inflammatory and anti‐hyperalgesic effects induced by an aqueous aged black garlic extract in rodent models of ulcerative colitis and colitis‐associated visceral pain. PHYTOTHERAPY RESEARCH, vol. 38, pp. 4177-4188, ISSN:0951-418X DOI  

  Lucarini, Elena; D'Antogiovanni, Vanessa; Antonioli, Luca; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo; Ferraroni, Marta; Locuoco, Maria; Capperucci, Antonella; Tanini, Damiano; Angeli, Andrea; Supuran, Claudiu T. (2024). Study of Chalcogen Aspirin Derivatives with Carbonic Anhydrase Inhibitory Properties for Treating Inflammatory Pain. ACS MEDICINAL CHEMISTRY LETTERS, pp. 0-0, ISSN:1948-5875 DOI  

  Micheli, Laura; Nobili, Stefania; Lucarini, Elena; Toti, Alessandra; Margiotta, Francesco; Ciampi, Clara; Venturi, Daniel; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla (2024). New insights in the mechanisms of opioid analgesia and tolerance: Ultramicronized palmitoylethanolamide down-modulates vascular endothelial growth factor-A in the nervous system. PHARMACOLOGICAL RESEARCH, vol. 209, pp. 0-0, ISSN:1043-6618 DOI  

  Nobili, Stefania; Micheli, Laura; Lucarini, Elena; Toti, Alessandra; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo (2024). Ultramicronized N-palmitoylethanolamine associated with analgesics: Effects against persistent pain. PHARMACOLOGY & THERAPEUTICS, vol. 258, pp. 0-0, ISSN:0163-7258 DOI  

  Vanti, Giulia; Micheli, Laura; Berrino, Emanuela; Mannelli, Lorenzo Di Cesare; Bogani, Irene; Carta, Fabrizio; Bergonzi, Maria Camilla; Supuran, Claudiu T; Ghelardini, Carla; Bilia, Anna Rita (2023). Escinosome thermosensitive gel optimizes efficacy of CAI-CORM in a rat model of rheumatoid arthritis. JOURNAL OF CONTROLLED RELEASE, vol. 358, pp. 171-189, ISSN:0168-3659 DOI   Accesso ONLINE all'editore

  Berrino, Emanuela; Micheli, Laura; Carradori, Simone; di Cesare Mannelli, Lorenzo; Guglielmi, Paolo; De Luca, Alessandro; Carta, Fabrizio; Ghelardini, Carla; Secci, Daniela; Supuran, Claudiu T (2023). Novel Insights on CAI-CORM Hybrids: Evaluation of the CO Releasing Properties and Pain-Relieving Activity of Differently Substituted Coumarins for the Treatment of Rheumatoid Arthritis. JOURNAL OF MEDICINAL CHEMISTRY, vol. 66, pp. 0-0, ISSN:0022-2623 DOI  

  Angeli A.; Micheli L.; Carta F.; Ferraroni M.; Pirali T.; Fernandez Carvajal A.; Ferrer Montiel A.; Di Cesare Mannelli L.; Ghelardini C.; Supuran C.T. (2023). First-in-Class Dual Hybrid Carbonic Anhydrase Inhibitors and Transient Receptor Potential Vanilloid 1 Agonists Revert Oxaliplatin-Induced Neuropathy. JOURNAL OF MEDICINAL CHEMISTRY, vol. 66, pp. 1616-1633, ISSN:0022-2623 DOI  

  Delprete, C.; Rimondini Giorgini, R.; Lucarini, E.; Bastiaanssen, T.F.S.; Scicchitano, D.; Interino, N.; Formaggio, F.; Uhlig, F.; Ghelardini, C.; Hyland, N.P.; Cryan, J.F.; Liguori, R.; Candela, M.; Fiori, J.; Turroni, S.; Di Cesare Mannelli, L.; Caprini, M. (2023). Disruption of the microbiota-gut-brain axis is a defining characteristic of the α-Gal A (-/0) mouse model of Fabry disease. GUT MICROBES, vol. 15, pp. 0-0, ISSN:1949-0976 DOI  

  Lucarini, Elena; Micheli, Laura; Rajagopalan, Raghavan; Ciampi, Clara; Branca, Jacopo Junio Valerio; Pacini, Alessandra; Leandri, Massimo; Rajagopalan, Parthasarathi; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo (2023). Broad-spectrum neuroprotection exerted by DDD-028 in a mouse model of chemotherapy-induced neuropathy. PAIN, vol. 00, pp. 0-0, ISSN:0304-3959 DOI   Accesso ONLINE all'editore

  Ferrara V.; Toti A.; Lucarini E.; Parisio C.; Micheli L.; Ciampi C.; Margiotta F.; Crocetti L.; Vergelli C.; Giovannoni M.P.; Di Cesare Mannelli L.; Ghelardini C. (2023). Protective and Pain-Killer Effects of AMC3, a Novel N-Formyl Peptide Receptors (FPRs) Modulator, in Experimental Models of Rheumatoid Arthritis. ANTIOXIDANTS, vol. 12, pp. 1207-1226, ISSN:2076-3921 DOI  

  Micheli L.; Rajamoni J.; Di Cesare Mannelli L.; Rajagopalan P.; Ghelardini C.; Rajagopalan R. (2023). DDD-028: A potent, neuroprotective, non-opioid compound for the treatment of diabetic neuropathy. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 95, pp. 0-0, ISSN:1464-3405 DOI  

  Lucarini E.; Micheli L.; Toti A.; Ciampi C.; Margiotta F.; Di Cesare Mannelli L.; Ghelardini C. (2023). Anti-Hyperalgesic Efficacy of Acetyl L-Carnitine (ALCAR) Against Visceral Pain Induced by Colitis: Involvement of Glia in the Enteric and Central Nervous System. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 24, pp. 0-0, ISSN:1422-0067 DOI  

  Angeli A.; Micheli L.; Turnaturi R.; Pasquinucci L.; Parenti C.; Alterio V.; Di Fiore A.; De Simone G.; Monti S.M.; Carta F.; Di Cesare Mannelli L.; Ghelardini C.; Supuran C.T. (2023). Discovery of a novel series of potent carbonic anhydrase inhibitors with selective affinity for μ Opioid receptor for Safer and long-lasting analgesia. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 260, pp. 0-0, ISSN:0223-5234 DOI  

  Laura Micheli, Lorenzo Di Cesare Mannelli, Elena Mosti, Carla Ghelardini, Anna Rita Bilia, Maria Camilla Bergonzi (2023). Antinociceptive Action of Thymoquinone-Loaded Liposomes in an In Vivo Model of Tendinopathy. PHARMACEUTICS, pp. 0-0, ISSN:1999-4923

  Arias, Hugo R; Tae, Han-Shen; Micheli, Laura; Yousuf, Arsalan; Manetti, Dina; Romanelli, Maria Novella; Ghelardini, Carla; Adams, David J; Di Cesare Mannelli, Lorenzo (2023). The Antinociceptive Activity of (E)-3-(thiophen-2-yl)- N -(p-tolyl)acrylamide in Mice Is Reduced by (E)-3-(furan-2-yl)- N -methyl- N -(p-tolyl)acrylamide Through Opposing Modulatory Mechanisms at the α7 Nicotinic Acetylcholine Receptor. ANESTHESIA AND ANALGESIA, vol. 137, pp. 691-701, ISSN:0003-2999 DOI  

  Balayssac D.; Busserolles J.; Broto C.; Dalbos C.; Prival L.; Lamoine S.; Richard D.; Quintana M.; Herbet A.; Hilairet S.; Hu Y.; Loryan I.; Glaab W.E.; Micheli L.; Ghelardini C.; Di Cesare Mannelli L.; Perrault O.; Slaoui M. (2023). Neurofilament light chain in plasma as a sensitive diagnostic biomarker of peripheral neurotoxicity: In Vivo mouse studies with oxaliplatin and paclitaxel - NeuroDeRisk project. BIOMEDICINE & PHARMACOTHERAPY, vol. 167, pp. 0-0, ISSN:1950-6007 DOI  

  Micheli, Laura; Lucarini, Elena; Nobili, Stefania; Bartolucci, Gianluca; Pallecchi, Marco; Toti, Alessandra; Ferrara, Valentina; Ciampi, Clara; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo (2022). Ultramicronized N-palmitoylethanolamine contributes to morphine efficacy against neuropathic pain: implication of mast cells and glia. CURRENT NEUROPHARMACOLOGY, vol. 21, pp. 0-0, ISSN:1570-159X DOI  

  Micheli L.; Parisio C.; Lucarini E.; Carrino D.; Ciampi C.; Toti A.; Ferrara V.; Pacini A.; Ghelardini C.; Di Cesare Mannelli L. (2022). Restorative and pain-relieving effects of fibroin in preclinical models of tendinopathy. BIOMÉDECINE & PHARMACOTHÉRAPIE, vol. 148, pp. 112693-112693, ISSN:0753-3322 DOI  

  Avagliano, Carmen; De Caro, Carmen; Cuozzo, Mariarosaria; Liguori, Fabrizio Maria; La Rana, Giovanna; Micheli, Laura; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Paciello, Orlando; Russo, Roberto (2022). Phaseolus vulgaris extract ameliorates high-fat diet-induced colonic barrier dysfunction and inflammation in mice by regulating peroxisome proliferator-activated receptor expression and butyrate levels. FRONTIERS IN PHARMACOLOGY, vol. 13, pp. 0-0, ISSN:1663-9812 DOI  

  Micheli, Laura; Maramai, Samuele; Toti, Alessandra; Ferrara, Valentina; Ciampi, Clara; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla (2022). Inhibition of Monoacylglycerol Lipase by NSD1819 as an Effective Strategy for the Endocannabinoid System Modulation against Neuroinflammation-Related Disorders. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, pp. 0-0, ISSN:1422-0067 DOI  

  Micheli, Laura; Toti, Alessandra; Lucarini, Elena; Ferrara, Valentina; Ciampi, Clara; Olivero, Guendalina; Pittaluga, Anna; Mattoli, Luisa; Pelucchini, Caroline; Burico, Michela; Lucci, Jacopo; Carrino, Donatello; Pacini, Alessandra; Pallanti, Stefano; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla (2022). Efficacy of a vegetal mixture composed of Zingiber officinale, Echinacea purpurea, and Centella asiatica in a mouse model of neuroinflammation: In vivo and ex vivo analysis. FRONTIERS IN NUTRITION, vol. 9, pp. 0-0, ISSN:2296-861X DOI  

  Lucarini E.; Micheli L.; Pagnotta E.; Toti A.; Ferrara V.; Ciampi C.; Margiotta F.; Martelli A.; Testai L.; Calderone V.; Matteo R.; Suriano S.; Troccoli A.; Pecchioni N.; Manera C.; Di Cesare Mannelli L.; Ghelardini C. (2022). The Efficacy of Camelina sativa Defatted Seed Meal against Colitis-Induced Persistent Visceral Hypersensitivity: The Relevance of PPAR α Receptor Activation in Pain Relief. NUTRIENTS, vol. 14, pp. 3137-3137, ISSN:2072-6643 DOI  

  Crocetti, Letizia; Guerrini, Gabriella; Giovannoni, Maria Paola; Melani, Fabrizio; Lamanna, Silvia; Di Cesare Mannelli, Lorenzo; Lucarini, Elena; Ghelardini, Carla; Wang, Junjie; Dahl, Gerhard (2022). New Panx-1 Blockers: Synthesis, Biological Evaluation and Molecular Dynamic Studies. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, pp. 4827-4855, ISSN:1422-0067 DOI  

  Coppi E.; Cherchi F.; Venturini M.; Lucarini E.; Corradetti R.; Mannelli Di Cesare Lorenzo.; Ghelardini C.; Pedata F.; Pugliese A.M. (2022). Therapeutic Potential of Highly Selective A3 Adenosine Receptor Ligands in the Central and Peripheral Nervous System. MOLECULES, vol. 27, pp. 1890-1904, ISSN:1420-3049 DOI  

  Gado F.; Ferrisi R.; Polini B.; Mohamed K.A.; Ricardi C.; Lucarini E.; Carpi S.; Domenichini F.; Stevenson L.A.; Rapposelli S.; Saccomanni G.; Nieri P.; Ortore G.; Pertwee R.G.; Ghelardini C.; Di Cesare Mannelli L.; Chiellini G.; Laprairie R.B.; Manera C. (2022). Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: From Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands. JOURNAL OF MEDICINAL CHEMISTRY, vol. 65, pp. 9918-9938, ISSN:1520-4804 DOI  

  Micheli, Laura; Mitidieri, Emma; Turnaturi, Carlotta; Vanacore, Domenico; Ciampi, Clara; Lucarini, Elena; Cirino, Giuseppe; Ghelardini, Carla; Sorrentino, Raffaella; Di Cesare Mannelli, Lorenzo; d'Emmanuele di Villa Bianca, Roberta (2022). Beneficial Effect of H2S-Releasing Molecules in an In Vitro Model of Sarcopenia: Relevance of Glucoraphanin. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, pp. 5955-5955, ISSN:1422-0067 DOI  

  Bonardi, Alessandro; Micheli, Laura; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Gratteri, Paola; Nocentini, Alessio; Supuran, Claudiu T (2022). Development of Hydrogen Sulfide-Releasing Carbonic Anhydrases IX- and XII-Selective Inhibitors with Enhanced Antihyperalgesic Action in a Rat Model of Arthritis. JOURNAL OF MEDICINAL CHEMISTRY, vol. 65, pp. 13143-13157, ISSN:1520-4804 DOI  

  Branca, Jacopo Junio Valerio; Carrino, Donatello; Paternostro, Ferdinando; Morucci, Gabriele; Fiorillo, Claudia; Nicoletti, Claudio; Gulisano, Massimo; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo; Becatti, Matteo; Pacini, Alessandra (2022). The Protection of Zinc against Acute Cadmium Exposure: A Morphological and Molecular Study on a BBB In Vitro Model. CELLS, vol. 11, pp. 0-0, ISSN:2073-4409 DOI  

  Bonardi, Alessandro; Bua, Silvia; Combs, Jacob; Lomelino, Carrie; Andring, Jacob; Osman, Sameh Mohamed; Toti, Alessandra; Di Cesare Mannelli, Lorenzo; Gratteri, Paola; Ghelardini, Carla; McKenna, Robert; Nocentini, Alessio; Supuran, Claudiu T (2022). The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 930-939-939, ISSN:1475-6366 DOI  

  Vanti, Giulia; Capizzi, Michela; Mannelli, Lorenzo Di Cesare; Lucarini, Elena; Bergonzi, Maria Camilla; Ghelardini, Carla; Bilia, Anna Rita (2022). Escinosomes: Safe and Successful Nanovesicles to Deliver Andrographolide by a Subcutaneous Route in a Mice Model of Oxaliplatin-Induced Neuropathy. PHARMACEUTICS, vol. 14, pp. 493-493, ISSN:1999-4923 DOI   Accesso ONLINE all'editore

  Micheli L.; Lucarini E.; Toti A.; Ferrara V.; Ciampi C.; Parisio C.; Bartolucci G.; Di Cesare Mannelli L.; Ghelardini C. (2022). Effects of Ultramicronized N-Palmitoylethanolamine Supplementation on Tramadol and Oxycodone Analgesia and Tolerance Prevention. PHARMACEUTICS, vol. 14, pp. 403-403, ISSN:1999-4923 DOI  

  Lucarini E.; Micheli L.; Pagnotta E.; Matteo R.; Parisio C.; Toti A.; Ferrara V.; Ciampi C.; Martelli A.; Testai L.; Calderone V.; Savino M.; Russo M.; Pecchioni N.; Ghelardini C.; Di Cesare Mannelli L. (2022). Beneficial Effects of Eruca sativa Defatted Seed Meal on Visceral Pain and Intestinal Damage Resulting from Colitis in Rats. FOODS, vol. 11, pp. 580-580, ISSN:2304-8158 DOI  

  Vallarino G.; Salis A.; Lucarini E.; Turrini F.; Olivero G.; Roggeri A.; Damonte G.; Boggia R.; Di Cesare Mannelli L.; Ghelardini C.; Pittaluga A. (2022). Healthy Properties of a New Formulation of Pomegranate‐Peel Extract in Mice Suffering from Experimental Autoimmune Encephalomyelitis. MOLECULES, vol. 27, pp. 914-914, ISSN:1420-3049 DOI  

  Di Cesare Mannelli, Lorenzo; Micheli, Laura; Cervetto, Chiara; Toti, Alessandra; Lucarini, Elena; Parisio, Carmen; Marcoli, Manuela; Ghelardini, Carla (2022). Neuronal alarmin IL-1α evokes astrocyte-mediated protective signals: Effectiveness in chemotherapy-induced neuropathic pain. NEUROBIOLOGY OF DISEASE, vol. 168, pp. 105716-105716, ISSN:0969-9961 DOI  

  Lucarini E.; Micheli L.; Di Cesare Mannelli L.; Ghelardini C. (2022). Naturally occurring glucosinolates and isothiocyanates as a weapon against chronic pain: potentials and limits. PHYTOCHEMISTRY REVIEWS, vol. 21, pp. 647-665, ISSN:1568-7767 DOI  

  D'Antongiovanni, Vanessa; Pellegrini, Carolina; Benvenuti, Laura; Fornai, Matteo; Di Salvo, Clelia; Natale, Gianfranco; Ryskalin, Larisa; Bertani, Lorenzo; Lucarini, Elena; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Nemeth, Zoltan H; Haskó, György; Antonioli, Luca (2022). Anti-inflammatory Effects of Novel P2X4 Receptor Antagonists, NC-2600 and NP-1815-PX, in a Murine Model of Colitis. INFLAMMATION, vol. 45, pp. 1829-1847, ISSN:0360-3997 DOI  

  Margiotta, Francesco; Micheli, Laura; Ciampi, Clara; Ghelardini, Carla; McIntosh, J. Michael; Di Cesare Mannelli, Lorenzo (2022). Conus regius-Derived Conotoxins: Novel Therapeutic Opportunities from a Marine Organism. MARINE DRUGS, vol. 20, pp. 0-0, ISSN:1660-3397 DOI  

  Lucarini E, Di Pilato V, Parisio C, Micheli L, Toti A, Pacini A, Bartolucci G, Baldi S, Niccolai E, Amedei A, Rossolini GM, Nicoletti C, Cryan JF, O'Mahony SM, Ghelardini C, Di Cesare Mannelli L. (2022). Visceral sensitivity modulation by faecal microbiota transplantation: the active role of gut bacteria in pain persistence. PAIN, pp. 1-17, ISSN:1872-6623

  Akande, Titilayo; Khatib, Mohamad; Ola Salawu, Sule; Afolabi Akindahunsi, Akintunde; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Balli, Diletta; Cecchi, Lorenzo; Mulinacci, Nadia (2022). 1H NMR and HPLC-DAD-MS for the characterization of ellagitannins and triterpenoids of less investigated Anogeissus leiocarpus DC (Combretaceae) stem bark. FOOD CHEMISTRY, vol. 375, pp. 0-0, ISSN:0308-8146 DOI   Accesso ONLINE all'editore

  Morgese M.G.; Bove M.; Di Cesare Mannelli L.; Schiavone S.; Colia A.L.; Dimonte S.; Mhillaj E.; Sikora V.; Tucci P.; Ghelardini C.; Trabace L. (2022). Precision Medicine in Alzheimer’s Disease: Investigating Comorbid Common Biological Substrates in the Rat Model of Amyloid Beta-Induced Toxicity. FRONTIERS IN PHARMACOLOGY, vol. 12, pp. 799561-799561, ISSN:1663-9812 DOI  

  Battaglia, Luigi S; Dorati, Rossella; Maestrelli, Francesca; Conti, Bice; Gabriele, Mirko; Di Cesare Mannelli, Lorenzo; Selmin, Francesca; Cosco, Donato (2022). Repurposing of parentally administered active substances used to treat pain both systemically and locally. DRUG DISCOVERY TODAY, pp. 0-0, ISSN:1359-6446 DOI  

  Branca, Jacopo Junio Valerio; Carrino, Donatello; Paternostro, Ferdinando; Gulisano, Massimo; Becatti, Matteo; Di Cesare Mannelli, Lorenzo; Pacini, Alessandra (2021). Antioxidant support to ameliorate the oxaliplatin-dependent microglial alteration: morphological and molecular study. EUROPEAN JOURNAL OF HISTOCHEMISTRY, vol. 65, pp. 0-0, ISSN:2038-8306 DOI  

  Varano, Flavia; Catarzi, Daniela; Vigiani, Erica; Dal Ben, Diego; Buccioni, Michela; Marucci, Gabriella; Di Cesare Mannelli, Lorenzo; Lucarini, Elena; Ghelardini, Carla; Volpini, Rosaria; Colotta, Vittoria (2021). Design and Synthesis of Novel Thiazolo[5,4-d]pyrimidine Derivatives with High Affinity for Both the Adenosine A1 and A2A Receptors, and Efficacy in Animal Models of Depression. PHARMACEUTICALS, vol. 14, pp. 0-0, ISSN:1424-8247 DOI  

  Carrino, Donatello; Branca, Jacopo Junio Valerio; Becatti, Matteo; Paternostro, Ferdinando; Morucci, Gabriele; Gulisano, Massimo; Di Cesare Mannelli, Lorenzo; Pacini, Alessandra (2021). Alcohol-Induced Blood-Brain Barrier Impairment: An In Vitro Study. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, vol. 18, pp. 0-0, ISSN:1660-4601 DOI  

  Mariaconcetta Durante 1 2, Silvia Squillace 1 3 4, Filomena Lauro 1 3 5, Luigino Antonio Giancotti 1 3, Elisabetta Coppi, Federica Cherchi, Lorenzo Di Cesare Mannelli, Carla Ghelardini , Grant Kolar 3 6, Carrie Wahlman 1, Adeleye Opejin 7, Cuiying Xiao 8, Marc L Reitman 8, Dilip K Tosh 8, Daniel Hawiger 7, Kenneth A Jacobson 8, Daniela Salvemini 1 3 (2021). Adenosine A3 agonists reverse neuropathic pain via T cell-mediated production of IL-10. THE JOURNAL OF CLINICAL INVESTIGATION, pp. 0-0, ISSN:1558-8238

  Mura P.; Maestrelli F.; Cirri M.; Nerli G.; Di Cesare Mannelli L.; Ghelardini C.; Mennini N. (2021). Improvement of butamben anesthetic efficacy by the development of deformable liposomes bearing the drug as cyclodextrin complex. PHARMACEUTICS, vol. 13, pp. 0-0, ISSN:1999-4923 DOI  

  Micheli L.; Vasarri M.; Barletta E.; Lucarini E.; Ghelardini C.; Degl'Innocenti D.; Di Cesare Mannelli L. (2021). Efficacy of Posidonia oceanica Extract against Inflammatory Pain: In Vivo Studies in Mice. MARINE DRUGS, vol. 19, pp. 48-62, ISSN:1660-3397 DOI   Accesso ONLINE all'editore

  Angeli A.; Pinteala M.; Maier S.S.; Toti A.; Di Cesare Mannelli L.; Ghelardini C.; Selleri S.; Carta F.; Supuran C.T. (2021). Tellurides bearing benzensulfonamide as carbonic anhydrase inhibitors with potent antitumor activity. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 45, pp. 0-0, ISSN:0960-894X DOI  

  Branca, Jacopo Junio Valerio; Carrino, Donatello; Gulisano, Massimo; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo; Pacini, Alessandra (2021). Oxaliplatin-Induced Neuropathy: Genetic and Epigenetic Profile to Better Understand How to Ameliorate This Side Effect. FRONTIERS IN MOLECULAR BIOSCIENCES, vol. 8, pp. 0-0, ISSN:2296-889X DOI   Accesso ONLINE all'editore

  Nobili S.; Lucarini E.; Murzilli S.; Vanelli A.; Di Cesare Mannelli L.; Ghelardini C. (2021). Efficacy evaluation of plant products in the treatment of erectile dysfunction related to diabetes. NUTRIENTS, vol. 13, pp. 4520-4520, ISSN:2072-6643 DOI  

  Micheli L.; Durante M.; Lucarini E.; Sgambellone S.; Lucarini L.; Di Cesare Mannelli L.; Ghelardini C.; Masini E. (2021). The histamine h4 receptor participates in the anti-neuropathic effect of the adenosine a3 receptor agonist ib-meca: Role of cd4+ t cells. BIOMOLECULES, vol. 11, pp. 1447-1447, ISSN:2218-273X DOI  

  Congiu M.; Micheli L.; Santoni M.; Sagheddu C.; Muntoni A.L.; Makriyannis A.; Malamas M.S.; Ghelardini C.; Di Cesare Mannelli L.; Pistis M. (2021). N-Acylethanolamine Acid Amidase Inhibition Potentiates Morphine Analgesia and Delays the Development of Tolerance. NEUROTHERAPEUTICS, pp. 0-0, ISSN:1933-7213 DOI  

  Lucarini E.; Seguella L.; Vincenzi M.; Parisio C.; Micheli L.; Toti A.; Corpetti C.; Del Re A.; Squillace S.; Maftei D.; Lattanzi R.; Ghelardini C.; Di Cesare Mannelli L.; Esposito G. (2021). Role of enteric glia as bridging element between gut inflammation and visceral pain consolidation during acute colitis in rats. BIOMEDICINES, vol. 9, pp. 1671-1671, ISSN:2227-9059 DOI  

  Micheli L., Parisio C., Lucarini E., Vona A., Toti A., Pacini A., Mello T., Boccella S., Ricciardi F., Maione S., Graziani G., Lacal P.M., Failli P., Ghelardini C., Di Cesare Mannelli L. (2021). VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, pp. 1-19, ISSN:1756-9966 DOI  

  Micheli L., Rajagopalan R., Lucarini E., Toti A., Parisio C., Carrino D., Pacini A., Ghelardini C., Rajagopalan P., Di Cesare Mannelli L. (2021). Pain Relieving and Neuroprotective Effects of Non-opioid Compound, DDD-028, in the Rat Model of Paclitaxel-Induced Neuropathy. NEUROTHERAPEUTICS, pp. 1-13, ISSN:1933-7213 DOI  

  Crocetti, Letizia; Guerrini, Gabriella; Puglioli, Sara; Giovannoni, Maria Paola; Di Cesare Mannelli, Lorenzo; Lucarini, Elena; Ghelardini, Carla; Wang, Junjie; Dahl, Gerhard (2021). Design and synthesis of the first indole-based blockers of Panx-1 channel. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 223, pp. 113650-113660, ISSN:0223-5234 DOI  

  Branca Jacopo Junio Valerio; Carrino Donatello; Bruno Gaia; Paternostro Ferdinando; Di Cesare Mannelli Lorenzo; Becatti Matteo; Gulisano Massimo; Pacini Alessandra (2021). Zinc prevents Cadmium-induced glial stress and activation. EUROPEAN JOURNAL OF HISTOCHEMISTRY, vol. 65, pp. 8-9, ISSN:2038-8306 DOI  

  Crocetti, Letizia; Vergelli, Claudia; Guerrini, Gabriella; Giovannoni, Maria Paola; Kirpotina, Liliya N.; Khlebnikov, Andrei I.; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo; Lucarini, Elena; Schepetkin, Igor A.; Quinn, Mark T. (2021). Pyridinone Derivatives as Interesting Formyl Peptide Receptor (FPR) Agonists for the Treatment of Rheumatoid Arthritis. MOLECULES, vol. 26, pp. 6583-6583, ISSN:1420-3049 DOI   Accesso ONLINE all'editore

  Vanti, Giulia; Di Cesare Mannelli, Lorenzo; Micheli, Laura; Cinci, Lorenzo; Grifoni, Lucia; Bergonzi, Maria Camilla; Ghelardini, Carla; Bilia, Anna Rita (2021). The Anti-Arthritic Efficacy of Khellin Loaded in Ascorbyl Decanoate Nanovesicles after an Intra-Articular Administration. PHARMACEUTICS, vol. 13, pp. 1275-1275, ISSN:1999-4923 DOI  

  Lucrezia Caselli, Marco Mendozza, Beatrice Muzzi, Alessandra Toti, Costanza Montis, Tommaso Mello, Lorenzo Di Cesare Mannelli, Carla Ghelardini,Claudio Sangregorio, Debora Berti (2021). Lipid Cubic Mesophases Combined with Superparamagnetic Iron Oxide Nanoparticles: A Hybrid Multifunctional Platform with Tunable Magnetic Properties for Nanomedical Applications. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, pp. 9268-9268, ISSN:1661-6596 DOI  

  Coppi E.; Cherchi F.; Lucarini E.; Ghelardini C.; Pedata F.; Jacobson K.A.; Mannelli L.D.C.; Pugliese A.M.; Salvemini D. (2021). Uncovering the mechanisms of adenosine receptor-mediated pain control: Focus on the a3 receptor subtype. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, pp. 7952-7964, ISSN:1661-6596 DOI  

  Giuseppe Giannaccare 1, Carla Ghelardini, Alessandra Mancini 1, Vincenzo Scorcia 1, Lorenzo Di Cesare Mannelli (2021). New Perspectives in the Pathophysiology and Treatment of Pain in Patients with Dry Eye Disease. JOURNAL OF CLINICAL MEDICINE, pp. 108-108, ISSN:2077-0383

  Di Cesare Mannelli L.; Esposito F.P.; Sangiovanni E.; Pagano E.; Mannucci C.; Polini B.; Ghelardini C.; Dell'agli M.; Izzo A.A.; Calapai G.; de Pascale D.; Nieri P. (2021). Pharmacological Activities of Extracts and Compounds Isolated from Mediterranean Sponge Sources. PHARMACEUTICALS, vol. 14, pp. 1329-1329, ISSN:1424-8247 DOI  

  Alma Martelli 1 2 3, Eugenia Piragine 1, Era Gorica 1, Valentina Citi 1, Lara Testai , Eleonora Pagnotta 4, Luca Lazzeri 4, Nicola Pecchioni 5, Valerio Ciccone 6, Rosangela Montanaro 7, Lorenzo Di Cesare Mannelli , Carla Ghelardini , Vincenzo Brancaleone 7, Lucia Morbidelli 6, Vincenzo Calderone (2021). The H 2 S-Donor Erucin Exhibits Protective Effects against Vascular Inflammation in Human Endothelial and Smooth Muscle Cells. ANTIOXIDANTS, pp. 961-961, ISSN:2076-3921

  Martinelli I.; Tomassoni D.; Roy P.; Di Cesare Mannelli L.; Amenta F.; Tayebati S.K. (2021). Antioxidant properties of alpha-lipoic (Thioctic) acid treatment on renal and heart parenchyma in a rat model of hypertension. ANTIOXIDANTS, vol. 10, pp. 1006-1006, ISSN:2076-3921 DOI  

  Di Cesare Mannelli L.; Ceruti S.; Orellana J.A. (2021). Editorial: Astrocytes, a Kaleidoscope of Diversities, a Pharmacological Horizon. FRONTIERS IN PHARMACOLOGY, vol. 12, pp. 638239-638239, ISSN:1663-9812 DOI  

  Pacini A., Tomassoni D., Trallori E., Micheli L., Amenta F., Gherlardini C., Di Cesare Mannelli L., Traini E (2021). Comparative assessment of the activity of racemic and dextrorotatory forms of thioctic (alpha-lipoic) acid in low back pain: preclinical and clinical evidences, from an open randomized trial.. FRONTIERS IN PHARMACOLOGY, vol. 12, pp. 607572-607587, ISSN:1663-9812 DOI  

  Lucarini E., Nocentini A., Bonardi A., Chiaramonte N., Parisio C., Micheli L., Toti A., Ferrara V., Carrino D., Pacini A., Romanelli M.N., Supuran C.T., Ghelardini C., Di Cesare Mannelli L. (2021). Carbonic Anhydrase IV Selective Inhibitors Counteract the Development of Colitis-Associated Visceral Pain in Rats. CELLS, vol. 10, pp. 2540-2555, ISSN:2073-4409 DOI  

  Biagiotti G.; Angeli A.; Giacomini A.; Toniolo G.; Landini L.; Salerno G.; Di Cesare Mannelli L.; Ghelardini C.; Mello T.; Mussi S.; Ravelli C.; Marelli M.; Cicchi S.; Menna E.; Ronca R.; Supuran C.T.; Richichi B. (2021). Glyco-Coated CdSe/ZnS Quantum Dots as Nanoprobes for Carbonic Anhydrase IX Imaging in Cancer Cells. ACS APPLIED NANO MATERIALS, vol. 4, pp. 14153-14160, ISSN:2574-0970 DOI   Accesso ONLINE all'editore

  Bulli I.; Dettori I.; Coppi E.; Cherchi F.; Venturini M.; Mannelli L.D.C.; Ghelardini C.; Nocentini A.; Supuran C.T.; Pugliese A.M.; Pedata F. (2021). Role of carbonic anhydrase in cerebral ischemia and carbonic anhydrase inhibitors as putative protective agents. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, pp. 5029-5038, ISSN:1661-6596 DOI  

  Dettori I.; Fusco I.; Bulli I.; Gaviano L.; Coppi E.; Cherchi F.; Venturini M.; Di Cesare Mannelli L.; Ghelardini C.; Nocentini A.; Supuran C.T.; Pugliese A.M.; Pedata F. (2021). Protective effects of carbonic anhydrase inhibition in brain ischaemia in vitro and in vivo models. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 36, pp. 964-976, ISSN:1475-6366 DOI  

  Di Cesare Mannelli L.; Micheli L.; Lucarini E.; Parisio C.; Toti A.; Tenci B.; Zanardelli M.; Branca J.J.V.; Pacini A.; Ghelardini C. (2020). Effects of the combination of β-hydroxy-β-methyl butyrate and R(+) lipoic acid in a cellular model of sarcopenia. MOLECULES, vol. 25, pp. 1-18, ISSN:1420-3049 DOI  

  Luca Antonioli 1, Elena Lucarini , Catia Lambertucci 3, Matteo Fornai 1, Carolina Pellegrini 4, Laura Benvenuti 1, Lorenzo Di Cesare Mannelli, Andrea Spinaci 3, Gabriella Marucci 3, Corrado Blandizzi 1, Carla Ghelardini, Rosaria Volpini 3, Diego Dal Ben 3 (2020). The Anti-Inflammatory and Pain-Relieving Effects of AR170, an Adenosine A 3 Receptor Agonist, in a Rat Model of Colitis. CELLS, pp. 1509-1509, ISSN:2073-4409

  Nocentini A.; Alterio V.; Bua S.; Micheli L.; Esposito D.; Buonanno M.; Bartolucci G.; Osman S.M.; Alothman Z.A.; Cirilli R.; Pierini M.; Monti S.M.; Di Cesare Mannelli L.; Gratteri P.; Ghelardini C.; De Simone G.; Supuran C.T. (2020). Phenyl(thio)phosphon(amid)ate Benzenesulfonamides as Potent and Selective Inhibitors of Human Carbonic Anhydrases II and VII Counteract Allodynia in a Mouse Model of Oxaliplatin-Induced Neuropathy. JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, pp. 5185-5200, ISSN:0022-2623 DOI  

  Lucarini E., Trallori E., Tomassoni D., Amenta F., Ghelardini C., Pacini A.*, Di Cesare Mannelli L. (2020). Toxicological profile of the pain-relieving antioxidant compound thioctic acid in its racemic and enantiomeric forms.. ANTIOXIDANTS, vol. 9, pp. 749-764, ISSN:2076-3921 DOI  

  Parisio C.; Lucarini E.; Micheli L.; Toti A.; Bellumori M.; Cecchi L.; Calosi L.; Bani D.; Di Cesare Mannelli L.; Mulinacci N.; Ghelardini C. (2020). Extra virgin olive oil and related by-products (: Olea europaea L.) as natural sources of phenolic compounds for abdominal pain relief in gastrointestinal disorders in rats. FOOD & FUNCTION, vol. 11, pp. 10423-10435, ISSN:2042-6496 DOI   Accesso ONLINE all'editore

  De Caro, Carmen; Di Cesare Mannelli, Lorenzo; Branca, Jacopo Junio Valerio; Micheli, Laura; Citraro, Rita; Russo, Emilio; De Sarro, Giovambattista; Ghelardini, Carla; Calignano, Antonio; Russo, Roberto (2020). Pain Modulation in WAG/Rij Epileptic Rats (A Genetic Model of Absence Epilepsy): Effects of Biological and Pharmacological Histone Deacetylase Inhibitors. FRONTIERS IN PHARMACOLOGY, vol. 11, pp. 0-0, ISSN:1663-9812 DOI  

  Piragine E.; Flori L.; Di Cesare Mannelli L.; Ghelardini C.; Pagnotta E.; Matteo R.; Lazzeri L.; Martelli A.; Miragliotta V.; Pirone A.; Testai L.; Calderone V. (2020). Eruca sativa Mill. seed extract promotes anti-obesity and hypoglycemic effects in mice fed with a high-fat diet. PHYTOTHERAPY RESEARCH, pp. 0-0, ISSN:0951-418X DOI  

  Consalvi S.; Poce G.; Ghelardini C.; Di Cesare Mannelli L.; Patrignani P.; Bruno A.; Anzini M.; Calderone V.; Martelli A.; Testai L.; Giordani A.; Biava M. (2020). Therapeutic potential for coxibs-nitric oxide releasing hybrids in cystic fibrosis. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, pp. 0-0, ISSN:0223-5234 DOI  

  Arias H.R.; Ghelardini C.; Lucarini E.; Tae H.-S.; Yousuf A.; Marcovich I.; Manetti D.; Romanelli M.N.; Elgoyhen A.B.; Adams D.J.; Di Cesare Mannelli L. (2020). (E)-3-Furan-2-yl- N- p-tolyl-acrylamide and its Derivative DM489 Decrease Neuropathic Pain in Mice Predominantly by α7 Nicotinic Acetylcholine Receptor Potentiation. ACS CHEMICAL NEUROSCIENCE, vol. 11, pp. 3603-3614-3614, ISSN:1948-7193 DOI  

  Testai L.; Piragine E.; Piano I.; Flori L.; Da Pozzo E.; Miragliotta V.; Pirone A.; Citi V.; Di Cesare Mannelli L.; Brogi S.; Carpi S.; Martelli A.; Nieri P.; Martini C.; Ghelardini C.; Gargini C.; Calderone V. (2020). The Citrus Flavonoid Naringenin Protects the Myocardium from Ageing-Dependent Dysfunction: Potential Role of SIRT1. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, vol. 2020, pp. 1-15, ISSN:1942-0900 DOI  

  Maestrelli, Francesca; González-Rodríguez, María Luisa; Fernández-Romero, Ana-María; Mura, Paola Angela; Rabasco, Antonio M.; Micheli, Laura; Mannelli, Lorenzo Di Cesare; Ghelardini, Carla (2020). Curcumin-in-Cyclodextrins-in-Liposomes: An Alternative for Osteoarthritis Treatment. PROCEEDINGS, vol. 78, pp. 0-0, ISSN:2504-3900 DOI   Accesso ONLINE all'editore

  Lucarini, E; Coppi, E; Micheli, L; Parisio, C; Vona, A; Cherchi, F; Pugliese, AM; Pedata, F; Failli, P; Palomino, S; Wahl, J; Largent-Milnes, TM; Vanderah, TW; Tosh, DK; Jacobson, KA; Salvemini, D; Ghelardini, C; Mannelli, LD (2020). Acute visceral pain relief mediated by A(3)AR agonists in rats: involvement of N-type voltage-gated calcium channels. PAIN, vol. 161, pp. 2179-2190, ISSN:0304-3959 DOI  

  Cirri, Marzia; Maestrelli, Francesca; Mennini, Natascia; Di Cesare Mannelli, Lorenzo; Micheli, Laura; Ghelardini, Carla; Mura, Paola (2020). Development of a stable oral pediatric solution of hydrochlorothiazide by the combined use of cyclodextrins and hydrophilic polymers. INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 587, pp. 119692-119692, ISSN:0378-5173 DOI   Accesso ONLINE all'editore

  Parisio C.; Lucarini E.; Micheli L.; Toti A.; Mannelli L.D.C.; Antonini G.; Panizzi E.; Maidecchi A.; Giovagnoni E.; Lucci J.; Ghelardini C. (2020). Researching new therapeutic approaches for abdominal visceral pain treatment: Preclinical effects of an assembled system of molecules of vegetal origin. NUTRIENTS, vol. 12, pp. 0-0, ISSN:2072-6643 DOI  

  Bedini A.; Di Cesare Mannelli L.; Micheli L.; Baiula M.; Vaca G.; De Marco R.; Gentilucci L.; Ghelardini C.; Spampinato S. (2020). Functional Selectivity and Antinociceptive Effects of a Novel KOPr Agonist. FRONTIERS IN PHARMACOLOGY, vol. 11, pp. 0-0, ISSN:1663-9812 DOI  

  Micheli L.; Spitoni S.; Di Cesare Mannelli L.; Bilia A.R.; Ghelardini C.; Pallanti S. (2020). Bacopa monnieri as augmentation therapy in the treatment of anhedonia, preclinical and clinical evaluation. PHYTOTHERAPY RESEARCH, vol. 34, pp. 2331-2340, ISSN:0951-418X DOI  

  Parisio C.; Lucarini E.; Micheli L.; Toti A.; Khatib M.; Mulinacci N.; Calosi L.; Bani D.; Mannelli L.D.C.; Ghelardini C. (2020). Pomegranate mesocarp against colitis-induced visceral pain in rats: Effects of a decoction and its fractions. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, pp. 1-16, ISSN:1661-6596 DOI  

  Laura Micheli, Lorenzo Di Cesare Mannelli, Elena Lucarini, Carmen Parisio, Alessandra Toti, Bruno Fiorentino, Maria Adele Rigamonti, Laura Calosi, and Carla Ghelardini (2020). Intranasal Low-Dose Naltrexone Against Opioid Side Effects: A Preclinical Study. FRONTIERS IN PHARMACOLOGY, pp. 0-0, ISSN:1663-9812 DOI  

  Arias H.R.; Tae H.-S.; Micheli L.; Yousuf A.; Ghelardini C.; Adams D.J.; Di Cesare Mannelli L. (2020). Coronaridine congeners decrease neuropathic pain in mice and inhibit α9α10 nicotinic acetylcholine receptors and CaV2.2 channels. NEUROPHARMACOLOGY, vol. 175, pp. 0-0, ISSN:0028-3908 DOI  

  Caputi F.F.; Di Cesare Mannelli L.; Rullo L.; Micheli L.; Stamatakos S.; Posa L.; Ghelardini C.; Romualdi P.; Candeletti S. (2020). The active second-generation proteasome inhibitor oprozomib reverts the oxaliplatin-induced neuropathy symptoms. BIOCHEMICAL PHARMACOLOGY, vol. 182, pp. 0-0, ISSN:0006-2952 DOI  

  Micheli L.; Di Cesare Mannelli L.; Del Bello F.; Giannella M.; Piergentili A.; Quaglia W.; Carrino D.; Pacini A.; Ghelardini C. (2020). The Use of the Selective Imidazoline I1 Receptor Agonist Carbophenyline as a Strategy for Neuropathic Pain Relief: Preclinical Evaluation in a Mouse Model of Oxaliplatin-Induced Neurotoxicity. NEUROTHERAPEUTICS, pp. 0-0, ISSN:1933-7213 DOI  

  D. Carrino, JJV Branca, L. Di Cesare Mannelli, F. Paternostro, S. Bonechi, G. Morucci, M. Gulisano, A. Pacini (2020). Update on zinc protection against Cd-induced BBB impairment. In: 30th National Conference of the Italian Group for the Study of Neuromorphology “Gruppo Italiano per lo Studio della Neuromorfologia” G.I.S.N. PROCEEDINGS, Torino (Virtual event), November 12-14, 2020, PAGEPress, Pavia, Italy, pp. 12-12.

  JJV. Branca,D. Carrino, F. Paternostro,M. Gulisano, M.Becatti, L. Di Cesare Mannelli, A. Pacini (2020). Mn and Mg protect against the oxaliplatindependent NVU impairment. In: 30th National Conference of the Italian Group for the Study of Neuromorphology “Gruppo Italiano per lo Studio della Neuromorfologia” G.I.S.N. PROCEEDINGS, Torino (Virtual event), November 12-14, 2020, PAGEPress, Pavia, Italy, pp. 18-18. DOI  

  Arena C.; Gado F.; Di Cesare Mannelli L.; Cervetto C.; Carpi S.; Reynoso-Moreno I.; Polini B.; Vallini E.; Chicca S.; Lucarini E.; Bertini S.; D'Andrea F.; Digiacomo M.; Poli G.; Tuccinardi T.; Macchia M.; Gertsch J.; Marcoli M.; Nieri P.; Ghelardini C.; Chicca A.; Manera C. (2020). The endocannabinoid system dual-target ligand N-cycloheptyl-1,2-dihydro-5-bromo-1-(4-fluorobenzyl)-6-methyl-2-oxo-pyridine-3-carboxamide improves disease severity in a mouse model of multiple sclerosis. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 208, pp. 112858-112858, ISSN:0223-5234 DOI  

  Alfonsina D’Amato, Lorenzo Di Cesare-Mannelli, Elena Lucarini, Angela L. Man, Gwenaelle Le Gall, Jacopo Branca, Carla Ghelardini, Amedeo Amedei, Eugenio Bertelli, Mari Regoli, Alessandra Pacini, Giulia Luciani, Pasquale Gallina, Annalisa Altera, Arjan Narbad, Massimo Gulisano, Lesley Hoyles, David Vauzour4, Claudio Nicoletti (2020). Faecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients. MICROBIOME, vol. 8, pp. 1-19, ISSN:2049-2618 DOI  

  Crocetti L.; Vergelli C.; Guerrini G.; Cantini N.; Kirpotina L.N.; Schepetkin I.A.; Quinn M.T.; Parisio C.; Di Cesare Mannelli L.; Ghelardini C.; Giovannoni M.P. (2020). Novel formyl peptide receptor (FPR) agonists with pyridinone and pyrimidindione scaffolds that are potentially useful for the treatment of rheumatoid arthritis. BIOORGANIC CHEMISTRY, vol. 100, pp. 1-12, ISSN:0045-2068 DOI  

  Soleimanian, Yasamin; Goli, Sayed Amir Hossein; Varshosaz, Jaleh; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Cirri, Marzia; Maestrelli, Francesca (2020). β-Sitosterol Loaded Nanostructured Lipid Carrier: Physical and Oxidative Stability, In Vitro Simulated Digestion and Hypocholesterolemic Activity. PHARMACEUTICS, vol. 12, pp. 0-0, ISSN:1999-4923 DOI   Accesso ONLINE all'editore

  Laura Micheli, Alessandra Pacini, Lorenzo Di Cesare Mannelli, Elena Trallori, Carla Ghelardini (2020). Treatment of Non-Alcoholic Steatosis: Preclinical Study of a New Nutraceutical Multitarget Formulation.. NUTRIENTS, vol. 12, pp. 1819-1842, ISSN:2072-6643 DOI  

  Lucarini E.; Parisio C.; Branca J.J.V.; Segnani C.; Ippolito C.; Pellegrini C.; Antonioli L.; Fornai M.; Micheli L.; Pacini A.; Bernardini N.; Blandizzi C.; Ghelardini C.; Di Cesare Mannelli L. (2020). Deepening the Mechanisms of Visceral Pain Persistence: An Evaluation of the Gut-Spinal Cord Relationship. CELLS, vol. 9, pp. 0-0, ISSN:2073-4409 DOI  

  Bua S.; Lucarini L.; Micheli L.; Menicatti M.; Bartolucci G.; Selleri S.; Di Cesare Mannelli L.; Ghelardini C.; Masini E.; Carta F.; Gratteri P.; Nocentini A.; Supuran C.T. (2020). Bioisosteric Development of Multitarget Nonsteroidal Anti-Inflammatory Drug-Carbonic Anhydrases Inhibitor Hybrids for the Management of Rheumatoid Arthritis. JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, pp. 2325-2342, ISSN:0022-2623 DOI   Accesso ONLINE all'editore

  Di Capua A, Reale A, Paolino M, Chemi G, Brogi S, Cappelli A, Giorgi G, Grande F, Di Cesare Mannelli L, Ghelardini C, Matucci R, Garofalo A, Anzini M. (2020). Design, synthesis and biological evaluation of 7-substituted 4-phenyl-6H-imidazo[1,5-a]thieno[3,2-f] [1,4]diazepines as safe anxiolytic agents.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 200, pp. 1-11, ISSN:1768-3254 Accesso ONLINE all'editore

  Micheli L, Lucarini E, Trallori E, Avagliano C, De Caro C, Russo R, Calignano A, Ghelardini C, Pacini A, Di Cesare Mannelli L. (2019). Phaseolus vulgaris L. Extract: Alpha-Amylase Inhibition against Metabolic Syndrome in Mice .. NUTRIENTS, vol. 11, pp. 1778-1797, ISSN:2072-6643 DOI  

  Falsini, Matteo; Catarzi, Daniela; Varano, Flavia; Dal Ben, Diego; Marucci, Gabriella; Buccioni, Michela; Volpini, Rosaria; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Colotta, Vittoria* (2019). Novel 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives as potent human adenosine A 1 and A 2A receptor antagonists. Evaluation of their protective effect against β-amyloid-induced neurotoxicity in SH-SY5Y cells. BIOORGANIC CHEMISTRY, vol. 87, pp. 380-394, ISSN:0045-2068 DOI   Accesso ONLINE all'editore

  Reale A, Brogi S, Chelini A, Paolino M1, Di Capua A, Giuliani G, Cappelli A, Giorgi G, Chemi G, Grillo A, Valoti M, Sautebin L, Rossi A, Pace S, La Motta C, Di Cesare Mannelli L, Lucarini E, Ghelardini C, Anzini M (2019). Synthesis, biological evaluation and molecular modeling of novel selective COX-2 inhibitors: sulfide, sulfoxide, and sulfone derivatives of 1,5-diarylpyrrol-3-substituted scaffold. BIOORGANIC & MEDICINAL CHEMISTRY, pp. 0-0, ISSN:0968-0896 DOI  

  Recinella L, Chiavaroli A, Orlando G, Menghini L, Ferrante C, Di Cesare Mannelli L, Ghelardini C, Brunetti L, Leone S (2019). Protective Effects Induced by Two Polyphenolic Liquid Complexes from Olive (Olea europaea, mainly Cultivar Coratina) Pressing Juice in Rat Isolated Tissues Challenged with LPS.. MOLECULES, pp. 0-0, ISSN:1420-3049 DOI  

  Carmen De Caro, Antonio Leo, Valentina Nesci, Carla Ghelardini, Lorenzo di Cesare Mannelli, Pasquale Striano, Carmen Avagliano, Antonio Calignano, Paolo Mainardi, Andrew Constanti, Rita Citraro, Giovambattista De Sarro, and Emilio Russo (2019). Intestinal inflammation increases convulsant activity and reduces antiepileptic drug efficacy in a mouse model of epilepsy.. SCIENTIFIC REPORTS, vol. 9, pp. 0-0, ISSN:2045-2322 DOI  

  Andrea Angeli; Lorenzo Di Cesare Mannelli; Carla Ghelardini; Thomas S. Peat; Gianluca Bartolucci; Marta Menicatti; Fabrizio Carta; Claudiu T. Supuran (2019). Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases {II} and {VII} and show neuropathic pain attenuating effects. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 177, pp. 188-197, ISSN:1768-3254 DOI  

  Gado F, Di Cesare Mannelli L, Lucarini E, Bertini S, Cappelli E, Digiacomo M, Stevenson LA, Macchia M, Tuccinardi T, Ghelardini C, Pertwee RG, Manera C (2019). Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief. JOURNAL OF MEDICINAL CHEMISTRY, vol. 62, pp. 276-287, ISSN:0022-2623 DOI  

  Micheli L.; Bozdag M.; Akgul O.; Carta F.; Guccione C.; Bergonzi M.C.; Bilia A.R.; Cinci L.; Lucarini E.; Parisio C.; Supuran C.T.; Ghelardini C.; Di Cesare Mannelli L. (2019). Pain relieving effect of-NSAIDS-CAIs hybrid molecules: Systemic and intra-articular treatments against rheumatoid arthritis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 20, pp. 1923-1938, ISSN:1422-0067 DOI   Accesso ONLINE all'editore

  Angeli A.; Di Cesare Mannelli L.; Ghelardini C.; Peat T.S.; Bartolucci G.; Menicatti M.; Carta F.; Supuran C.T. (2019). Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 177, pp. 188-197, ISSN:1768-3254 DOI   Accesso ONLINE all'editore

  Dina Manetti*† , Alexandra Garifulina‡, Gian Luca Bartolucci , Carla Bazzicalupi§ , Cristina Bellucci†, Niccolò Chiaramonte†, Silvia Dei†, Lorenzo Di Cesare Mannelli∥, Carla Ghelardini∥, Paola Gratteri⊥ , Ekaterina Spirova‡, Irina Shelukhina‡, Elisabetta Teodori†, Katia Varani#, Victor Tsetlin‡, Maria Novella Romanelli† (2019). New Rigid Nicotine Analogues, Carrying a Norbornane Moiety, Are Potent Agonists of α7 and α3∗ Nicotinic Receptors. JOURNAL OF MEDICINAL CHEMISTRY, vol. 62, pp. 1887-1901, ISSN:0022-2623 DOI   Accesso ONLINE all'editore

  Domazetovic V, Marcucci G, Pierucci F, Bruno G, Di Cesare Mannelli L, Ghelardini C, Brandi ML, Iantomasi T, Meacci E, Vincenzini MT. (2019). Blueberry juice protects osteocytes and bone precursor cells against oxidative stress partly through SIRT1. FEBS OPEN BIO, vol. 9 (6), pp. 1082-1096, ISSN:2211-5463, Wiley Blackwell: DOI   Accesso ONLINE all'editore

  Bozdag M.; Poli G.; Angeli A.; Lucarini E.; Tuccinardi T.; Di Cesare Mannelli L.; Selleri S.; Ghelardini C.; Winum J.-Y.; Carta F.; Supuran C.T. (2019). N-aryl-N’-ureido-O-sulfamates: Potent and selective inhibitors of the human Carbonic Anhydrase VII isoform with neuropathic pain relieving properties. BIOORGANIC CHEMISTRY, vol. 89, pp. 103033-103043, ISSN:0045-2068 DOI   Accesso ONLINE all'editore

  Tanini, Damiano; Ricci, Lorenzo; Capperucci, Antonella; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Peat, Thomas S; Carta, Fabrizio; Angeli, Andrea; Supuran, Claudiu T (2019). Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 181, pp. 111586-111594, ISSN:1768-3254 DOI  

  Berrino E.; Milazzo L.; Micheli L.; Vullo D.; Angeli A.; Bozdag M.; Nocentini A.; Menicatti M.; Bartolucci G.; Di Cesare Mannelli L.; Ghelardini C.; Supuran C.T.; Carta F. (2019). Synthesis and evaluation of carbonic anhydrase inhibitors with carbon monoxide releasing properties for the management of rheumatoid arthritis. JOURNAL OF MEDICINAL CHEMISTRY, vol. 62, pp. 7233-7249, ISSN:1520-4804 DOI  

  Laura Micheli, Murat Bozdag , Ozlem Akgul , Fabrizio Carta , Clizia Guccione, Maria Camilla Bergonzi, Anna Rita Bilia, Lorenzo Cinci, Elena Lucarini, Carmen Parisio, Claudiu T. Supuran , Carla Ghelardini, Lorenzo Di Cesare Mannelli (2019). Pain Relieving Eect of-NSAIDs-CAIs Hybrid Molecules: Systemic and Intra-Articular Treatments against Rheumatoid Arthritis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, pp. 0-0, ISSN:1422-0067

  Branca J.J.V.; Morucci G.; Becatti M.; Carrino D.; Ghelardini C.; Gulisano M.; Di Cesare Mannelli L.; Pacini A. (2019). Cannabidiol protects dopaminergic neuronal cells from cadmium. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, vol. 16, pp. 0-0, ISSN:1660-4601 DOI   Accesso ONLINE all'editore

  Bonfiglio T, Olivero G, Vergassola M, Di Cesare Mannelli L, Pacini A, Iannuzzi F, Summa M, Bertorelli R, Feligioni M, Ghelardini C, Pittaluga A. (2019). Environmental training is beneficial to clinical symptoms and cortical presynaptic defects in mice suffering from experimental autoimmune encephalomyelitis.. NEUROPHARMACOLOGY, vol. 145, pp. 75-86, ISSN:0028-3908 DOI   Accesso ONLINE all'editore

  Coppi, Elisabetta; Cherchi, Federica; Fusco, Irene; Failli, Paola; Vona, Alessia; Dettori, Ilaria; Gaviano, Lisa; Lucarini, Elena; Jacobson, Kenneth A; Tosh, Dilip K; Salvemini, Daniela; Ghelardini, Carla; Pedata, Felicita; Di Cesare Mannelli, Lorenzo; Pugliese, Anna Maria (2019). Adenosine A3 receptor activation inhibits pro-nociceptive N-type Ca2+ currents and cell excitability in dorsal root ganglion neurons. PAIN, pp. 1-16, ISSN:0304-3959 DOI  

  Lucarini E, Pagnotta E, Micheli L, Parisio C, Testai L, Martelli A, Calderone V, Matteo R, Lazzeri L, Di Cesare Mannelli L, Ghelardini C (2019). Eruca sativa Meal against Diabetic Neuropathic Pain: An H2S-Mediated Effect of Glucoerucin. MOLECULES, pp. 0-0, ISSN:1420-3049 DOI  

  Elena Trallori, Carla Ghelardini, Lorenzo Di Cesare Mannelli (2019). Mesenchymal stem cells, implications for pain therapy.. NEURAL REGENERATION RESEARCH, pp. 0-0, ISSN:1673-5374 DOI  

  Branca J.J.V. , Maresca M. , Morucci G. , Mello T. , Becatti M. , Pazzagli L. , Colzi I. , Gonnelli C. , Carrino D. , Paternostro F. , Nicoletti C. , Ghelardini C. , Gulisano M. , Di Cesare Mannelli L. , Pacini A. (2019). Effects of Cadmium on ZO-1 Tight Junction Integrity of the Blood Brain Barrier.. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 20, pp. 1-19, ISSN:1422-0067 DOI  

  Piazzini, Vieri; Micheli, Laura; Luceri, Cristina; D'Ambrosio, Mario; Cinci, Lorenzo; Ghelardini, Carla; Rita Bilia, Anna; Di Cesare Mannelli, Lorenzo; Camilla Bergonzi, Maria (2019). Nanostructured lipid carriers for oral delivery of silymarin: improving its absorption and in vivo efficacy in type 2 diabetes and metabolic syndrome model. INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. ---, pp. 0-0, ISSN:0378-5173 DOI   Accesso ONLINE all'editore

  Martelli A, Piragine E, Citi V, Testai L, Pagnotta E, Ugolini L, Lazzeri L, Di Cesare Mannelli L, Manzo OL, Bucci M, Ghelardini C, Breschi MC, Calderone V (2019). Erucin exhibits vasorelaxing effects and antihypertensive activity by H2 S-releasing properties. BRITISH JOURNAL OF PHARMACOLOGY, pp. 0-0, ISSN:0007-1188 DOI  

  Citi V, Piragine E, Pagnotta E, Ugolini L, Di Cesare Mannelli L, Testai L, Ghelardini C, Lazzeri L, Calderone V, Martelli A (2019). Anticancer properties of erucin, an H2 S-releasing isothiocyanate, on human pancreatic adenocarcinoma cells (AsPC-1).. PHYTOTHERAPY RESEARCH, pp. 0-0, ISSN:0951-418X DOI  

  Micheli L, Ghelardini C, Lucarini E, Parisio C, Trallori E, Cinci L, Di Cesare Mannelli L (2019). Intra-articular mucilages: behavioural and histological evaluations for a new model of articular pain.. JOURNAL OF PHARMACY AND PHARMACOLOGY, pp. 971-981, ISSN:0022-3573 DOI  

  Falsini M.; Catarzi D.; Varano F.; Ceni C.; Dal Ben D.; Marucci G.; Buccioni M.; Volpini R.; Di Cesare Mannelli L.; Lucarini E.; Ghelardini C.; Bartolucci G.; Menicatti M.; Colotta V. (2019). Antioxidant-Conjugated 1,2,4-Triazolo[4,3-a]pyrazin-3-one Derivatives: Highly Potent and Selective Human A2A Adenosine Receptor Antagonists Possessing Protective Efficacy in Neuropathic Pain. JOURNAL OF MEDICINAL CHEMISTRY, vol. 62, pp. 8511-8531, ISSN:1520-4804 DOI  

  Betti, Marco; Catarzi, Daniela; Varano, Flavia; Falsini, Matteo; Varani, Katia; Vincenzi, Fabrizio; Pasquini, Silvia; di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Lucarini, Elena; Dal Ben, Diego; Spinaci, Andrea; Bartolucci, Gian Luca; Menicatti, Marta; Colotta, Vittoria (2019). Modifications on the Amino-3,5-dicyanopyridine Core To Obtain Multifaceted Adenosine Receptor Ligands with Antineuropathic Activity. JOURNAL OF MEDICINAL CHEMISTRY, vol. 62, pp. 6894-6912, ISSN:0022-2623 DOI  

  Micheli L, Cialdai F, Pacini A, Branca JJV, Morbidelli L, Ciccone V, Lucarini E, Ghelardini C, Monici M, Di Cesare Mannelli L (2019). Effect of NIR laser therapy by MLS-MiS source against neuropathic pain in rats: in vivo and ex vivo analysis.. SCIENTIFIC REPORTS, vol. 9, pp. 9297-9306, ISSN:2045-2322 DOI  

  Marzia Cirri, Francesca Maestrelli , Paola Mura, Carla Ghelardini, Lorenzo Di Cesare Mannelli (2018). Combined Approach of Cyclodextrin Complexation and Nanostructured Lipid Carriers for the Development of a Pediatric Liquid Oral Dosage Form of Hydrochlorothiazide. PHARMACEUTICS, vol. 10, pp. 0-0, ISSN:1999-4923 DOI  

  Bonardi, Alessandro; Falsini, Matteo; Catarzi, Daniela; Varano, Flavia; Di Cesare Mannelli, Lorenzo; Tenci, Barbara; Ghelardini, Carla; Angeli, Andrea; Supuran, Claudiu T.; Colotta, Vittoria* (2018). Structural investigations on coumarins leading to chromeno[4,3-c]pyrazol-4-ones and pyrano[4,3-c]pyrazol-4-ones: New scaffolds for the design of the tumor-associated carbonic anhydrase isoforms IX and XII. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 146, pp. 47-59, ISSN:0223-5234 DOI   Accesso ONLINE all'editore

  Dini, Leonardo; Del Lungo, Martina; Resta, Francesco; Melchiorre, Michele; Spinelli, Valentina; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Laurino, Annunziatina; Sartiani, Laura; Coppini, Raffaele; Mannaioni, Guido; Cerbai, Elisabetta; Romanelli, Maria Novella (2018). Selective Blockade of HCN1/HCN2 Channels as a Potential Pharmacological Strategy Against Pain. FRONTIERS IN PHARMACOLOGY, vol. 9, pp. 1252-1252, ISSN:1663-9812 DOI  

  Aghazadeh Tabrizi, M; Baraldi, Pg; Baraldi, S; Ruggiero, E; De Stefano, L; Rizzolio, F; Di Cesare Mannelli, L; Ghelardini, C; Chicca, A; Lapillo, M; Gertsch, J; C, Manera; Macchia, M; Martinelli, A; Granchi, C; Minutolo, F; Tuccinardi, T. (2018). Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY, pp. .1340-.1354, ISSN:0022-2623 DOI  

  Francesca Cantini, Vito Calderone, Lorenzo Di Cesare Mannelli, Magdalena Korsak, Leonardo Gonnelli, Oscar Francesconi, Carla Ghelardini, Lucia Banci, and Cristina Nativi (2018). Interaction of Half Oxa-/Half cis-Platin Complex with Human Superoxide Dismutase and Induced Reduction of Neurotoxicity. ACS MEDICINAL CHEMISTRY LETTERS, vol. 9, pp. 1094-1098, ISSN:1948-5875 DOI  

  Micheli L., Mattoli L., Maidecchi A., Pacini A., Ghelardini C., Di Cesare Mannelli L. (2018). Effect of Vitis vinifera hydroalcoholic extract against oxaliplatin neurotoxicity: in vitro and in vivo evidence. SCIENTIFIC REPORTS, vol. 8, pp. 14364-14377, ISSN:2045-2322 DOI   Accesso ONLINE all'editore

  Di Cesare Mannelli L, Piccolo M, Maione F, Ferraro MG, Irace C, De Feo V, Ghelardini C, Mascolo N (2018). Tanshinones from Salvia miltiorrhiza Bunge revert chemotherapy-induced neuropathic pain and reduce glioblastoma cells malignancy. BIOMÉDECINE & PHARMACOTHÉRAPIE, pp. 1042-1049, ISSN:0753-3322 DOI  

  Marzia Cirri , Lavinia Maestrini , Francesca Maestrelli , Natascia Mennini , Paola Mura , Carla Ghelardini, Lorenzo Di Cesare Mannelli (2018). Design, characterization and in vivo evaluation of nanostructured lipid carriers (NLC) as a new drug delivery system for hydrochlorothiazide oral administration in pediatric therapy. DRUG DELIVERY, vol. 25, pp. 1910-1921, ISSN:1521-0464 DOI   Accesso ONLINE all'editore

  Angeli A, di Cesare Mannelli L, Lucarini E, Peat TS, Ghelardini C, Supuran CT (2018). Design, synthesis and X-ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, pp. 210-219, ISSN:0223-5234 DOI  

  Nocentini A, Trallori E, Singh S, Lomelino CL, Bartolucci G, Di Cesare Mannelli L, Ghelardini C, McKenna R, Gratteri P, Supuran CT (2018). 4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII showing hypoxia-enhanced anti-proliferative profiles.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 61, pp. 10860-10874, ISSN:0022-2623 DOI   Accesso ONLINE all'editore

  Di Cesare Mannelli L, Micheli L, Lucarini E, Ghelardini C (2018). Ultramicronized N-Palmitoylethanolamine Supplementation for Long-Lasting, Low-Dosed Morphine Antinociception. FRONTIERS IN PHARMACOLOGY, pp. 0-0, ISSN:1663-9812 DOI  

  Lucarini E, Micheli L, Trallori E, Citi V, Martelli A, Testai L, De Nicola G, Iori R, Calderone V, Ghelardini C, Di Cesare Mannelli L (2018). Effect of glucoraphanin and sulforaphane against chemotherapy-induced neuropathic pain: Kv7 potassium channels modulation by H2 S release in vivo.. PHYTOTHERAPY RESEARCH, pp. 2226-2234, ISSN:1099-1573 DOI  

  Brindisi M, Borrelli G, Brogi S, Grillo A, Maramai S, Paolino M, Benedusi M, Pecorelli A, Valacchi G, Di Cesare Mannelli L, Ghelardini C, Allarà M, Ligresti A, Minetti P, Campiani G, di Marzo V, Butini S, Gemma S (2018). Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain. CHEMMEDCHEM, pp. 2090-2103, ISSN:1860-7187 DOI  

  Bragagni M, Gil-Alegre ME, Mura P, Cirri M, Ghelardini C, Di Cesare Mannelli L (2018). Improving the therapeutic efficacy of prilocaine by PLGA microparticles: Preparation, characterization and in vivo evaluation.. INTERNATIONAL JOURNAL OF PHARMACEUTICS, pp. 24-30, ISSN:0378-5173 DOI  

  Angeli, Andrea; Di Cesare Mannelli, Lorenzo; Trallori, Elena; Peat, Thomas S.; Ghelardini, Carla; Carta, Fabrizio; Supuran, Claudiu T.* (2018). Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology. ACS MEDICINAL CHEMISTRY LETTERS, vol. 9, pp. 462-467, ISSN:1948-5875 DOI   Accesso ONLINE all'editore

  Angeli, Andrea; Trallori, Elena; Ferraroni, Marta; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Supuran, Claudiu T.* (2018). Discovery of new 2, 5-disubstituted 1,3-selenazoles as selective human carbonic anhydrase IX inhibitors with potent anti-tumor activity. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 157, pp. 1214-1222, ISSN:0223-5234 DOI   Accesso ONLINE all'editore

  Branca J.J.V. , Maresca M., Morucci G., Becatti M., Paternostro F., Gulisano M., Ghelardini C., Salvemini D., Di Cesare Mannelli L., Pacini A. (2018). OXALIPLATIN-INDUCED BLOOD BRAIN BARRIER LOOSENING: A NEW POINT OF VIEW ON CHEMOTHERAPY-INDUCED NEUROTOXICITY. ONCOTARGET, vol. 9, pp. 23426-23438, ISSN:1949-2553 DOI  

  Menicatti, Marta; Pallecchi, Marco; Bua, Silvia; Vullo, Daniela; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Carta, Fabrizio; Supuran, Claudiu T.; Bartolucci, Gianluca* (2018). Resolution of co-eluting isomers of anti-inflammatory drugs conjugated to carbonic anhydrase inhibitors from plasma in liquid chromatography by energy-resolved tandem mass spectrometry. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 33, pp. 671-679, ISSN:1475-6366 DOI  

  Akgul, Ozlem; Di Cesare Mannelli, Lorenzo; Vullo, Daniela; Angeli, Andrea; Ghelardini, Carla; Bartolucci, Gianluca; Altamimi, Abdulmalik Saleh Alfawaz; Scozzafava, Andrea; Supuran, Claudiu T; Carta, Fabrizio (2018). Discovery of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Management of Rheumatoid Arthritis. JOURNAL OF MEDICINAL CHEMISTRY, pp. 1-60, ISSN:0022-2623 DOI  

  Tomassoni D, Di Cesare Mannelli L, Bramanti V, Ghelardini C, Amenta F, Pacini A (2018). TREATMENT WITH ACETYL-L-CARNITINE EXERTS A NEUROPROTECTIVE EFFECT IN THE SCIATIC NERVE FOLLOWING LOOSE LIGATION: A FUNCTIONAL AND MICROANATOMICAL STUDY. NEURAL REGENERATION RESEARCH, vol. 13, pp. 692-698, ISSN:1673-5374 DOI  

  Resta, F.*; Micheli, L.; Laurino, A.; Spinelli, V.; Mello, T.; Sartiani, L.; Di Cesare Mannelli, L.; Cerbai, E.; Ghelardini, C.; Romanelli, M.N.; Mannaioni, G.; Masi, A. (2018). Selective HCN1 block as a strategy to control oxaliplatin-induced neuropathy. NEUROPHARMACOLOGY, vol. 131, pp. 403-413, ISSN:0028-3908 DOI   Accesso ONLINE all'editore

  Branca, Jacopo J V; Morucci, Gabriele; Maresca, Mario; Tenci, Barbara; Cascella, Roberta; Paternostro, Ferdinando; Ghelardini, Carla; Gulisano, Massimo; Di Cesare Mannelli, Lorenzo; Pacini, Alessandra (2018). Selenium and zinc: Two key players against cadmium-induced neuronal toxicity.. TOXICOLOGY IN VITRO, vol. 48, pp. 159-169, ISSN:0887-2333 DOI  

  Guida F.; Luongo L.; Di Cesare Mannelli L. (2018). New targets for treating chronic pain and inflammation. CURRENT MEDICINAL CHEMISTRY, vol. 25, pp. 3828-3829, ISSN:0929-8673 DOI  

  Angeli, Andrea; Trallori, Elena; Carta, Fabrizio; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Supuran, Claudiu T.* (2018). Heterocoumarins Are Selective Carbonic Anhydrase IX and XII Inhibitors with Cytotoxic Effects against Cancer Cells Lines. ACS MEDICINAL CHEMISTRY LETTERS, vol. 9, pp. 947-951, ISSN:1948-5875 DOI   Accesso ONLINE all'editore

  Lucarini E, Micheli L, Martelli A, Testai L, Calderone V, Ghelardini C, Di Cesare Mannelli L (2018). Efficacy of isothiocyanate-based compounds on different forms of persistent pain.. JOURNAL OF PAIN RESEARCH, pp. 2905-2913, ISSN:1178-7090 DOI  

  Micheli L, Lucarini E, Corti F, Ciccocioppo r, Calò G, Rizzi A, Ghelardini C, Di Cesare Mannelli L. (2018). Involvement of the N/OFQ-NOP system in rat morphine antinociceptive tolerance: Are astrocytes the crossroad?. EUROPEAN JOURNAL OF PHARMACOLOGY, pp. 79-86, ISSN:0014-2999 DOI  

  Angeli, Andrea; Tanini, Damiano; Peat, Thomas S. ; Di Cesare Mannelli,Lorenzo; Bartolucci, Gian Luca; Capperucci, Antonella; Ghelardini, Carla; Supuran, Claudiu T.; and Carta, Fabrizio (2017). Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors. ACS MEDICINAL CHEMISTRY LETTERS, vol. 8, pp. 963-968, ISSN:1948-5875 DOI   Accesso ONLINE all'editore

  Gabriella, Guerrini; Ciciani, Giovanna; Daniele, Simona; lorenzo di cesare mannelli, ; Ghelardini, Carla; Martini, Claudia; Silvia, Selleri (2017). Synthesis and pharmacological evaluation of pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives as potential GABAA-R ligands. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 25, pp. 1901-1906, ISSN:0968-0896 DOI  

  Di Cesare Mannelli, L; Pacini, A; Micheli, L; Femia, Ap; Maresca, M; Zanardelli, M; Vannacci, A; Gallo, E; Bilia, Ar; Caderni, G; Firenzuoli, F; Mugelli, A; Ghelardini, C (2017). Astragali radix: could it be an adjuvant for oxaliplatin-induced neuropathy?. SCIENTIFIC REPORTS, vol. 7, pp. 1-13, ISSN:2045-2322 DOI  

  Bonfiglio, T; Olivero, G; Merega, E; Di Prisco, S; Padolecchia, C; Grilli, M; Milanese, M; Di Cesare Mannelli, L; Ghelardini, C; Bonanno, G; Marchi, M; Pittaluga, A. (2017). Prophylactic versus Therapeutic Fingolimod: Restoration of Presynaptic Defects in Mice Suffering from Experimental Autoimmune Encephalomyelitis. PLOS ONE, pp. e0170825-e0170825, ISSN:1932-6203 DOI  

  Maresca, M; Micheli, L; Cinci, L; Bilia, Ar; Ghelardini, C; Di Cesare Mannelli, L. (2017). Pain relieving and protective effects of Astragalus hydroalcoholic extract in rat arthritis models. JOURNAL OF PHARMACY AND PHARMACOLOGY, pp. 1858-1870, ISSN:0022-3573 DOI  

  Maestrelli, Francesca; Mura, Paola; Cirri, Marzia; Mennini, Natascia; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo (2017). Development and characterization of fast dissolving tablets of oxaprozin based on hybrid systems of the drug with cyclodextrins and nanoclays. INTERNATIONAL JOURNAL OF PHARMACEUTICS, pp. 0-0, ISSN:0378-5173 DOI   Accesso ONLINE all'editore

  Angeli, Andrea; Tanini, Damiano; Peat, Thomas S. ; Di Cesare Mannelli,Lorenzo; Bartolucci, Gian Luca; Capperucci, Antonella; Ghelardini, Carla; Supuran, Claudiu T.; and Carta, Fabrizio (2017). Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors. ACS MEDICINAL CHEMISTRY LETTERS, vol. 8, pp. 963-968, ISSN:1948-5875 DOI   Accesso ONLINE all'editore

  Nocentini, Alessio; Bua, Silvia; Lomelino, Carrie L.; Mckenna, Robert; Menicatti, Marta; Bartolucci, Gianluca; Tenci, Barbara; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Gratteri, Paola; Supuran, Claudiu T. (2017). Discovery of New Sulfonamide Carbonic Anhydrase IX Inhibitors Incorporating Nitrogenous Bases. ACS MEDICINAL CHEMISTRY LETTERS, vol. 8, pp. 1314-1319, ISSN:1948-5875 DOI   Accesso ONLINE all'editore

  Branca, Jacopo J. V.; DI CESARE MANNELLI, Lorenzo; Maresca, Mario; Paternostro, Ferdinando; Sofia, Bonechi; Morucci, Gabriele; Gulisano, Massimo; Pacini, Alessandra (2017). Zinc protection in cadmium-induced Blood Brain Barrier permeability: a metabolic and morphological in vitro study. In: 71 th Meeting of the Italian Society of Anatomy and Histology, Messina - Taormina, Settembre 2017, FUP, vol. Vol. 119,, pp. 33-33. Accesso ONLINE all'editore

  Branca, Jacopo J. V.; Maresca, Mario; Morucci, Gabriele; Paternostro, Ferdinando; DI CESARE MANNELLI, Lorenzo; Gulisano, Massimo; Pacini, Alessandra (2017). Effects of the endoplasmic reticulum signaling pathway on cadmium-induced impairment of the blood brain barrier. In: 71 th Meeting of the Italian Society of Anatomy and Histology, Messina - Taormina, settembre 2017, FUP, vol. Vol. 119, pp. 32-32. Accesso ONLINE all'editore

  Guerrini, Gabriella; Ciciani, Giovanna; Crocetti, Letizia; Daniele, Simona; Ghelardini, Carla; Giovannoni, MARIA PAOLA; Iacovone, Antonella; DI CESARE MANNELLI, Lorenzo; Martini, Claudia; Vergelli, Claudia (2017). Identification of a new pyrazolo[1,5-a]quinazoline ligand highly affine to γ-aminobutyric type A (GABAA) receptor subtype with anxiolytic-like and antihyperalgesic activity. JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, pp. 9691-9702, ISSN:0022-2623 DOI  

  Fragai, Marco; Comito, Giuseppina; Di Cesare Mannelli, Lorenzo; Gualdani, Roberta; Calderone, Vito; Louka, Alexandra; Richichi, Barbara; Francesconi, Oscar; Angeli, Andrea; Nocentini, Alessio; Gratteri, Paola; Chiarugi, Paola; Ghelardini, Carla; Tadini-Buoninsegni, Francesco; Supuran, Claudiu T; Nativi, Cristina (2017). Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX). JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, pp. 9003-9011, ISSN:1520-4804 DOI  

  Cinci, L; Di Cesare Mannelli, L; Maidecchi, A; Mattoli, L; Ghelardini, C. (2017). Effects of Hypericum perforatum extract on oxaliplatin-induced neurotoxicity: in vitro evaluations. ZEITSCHRIFT FÜR NATURFORSCHUNG. C, A JOURNAL OF BIOSCIENCES, pp. 219-226, ISSN:0939-5075 DOI  

  Romero, Hk; Christensen, Sb; Di Cesare Mannelli, L; Gajewiak, J; Ramachandra, R; Elmslie, Ks; Vetter, De; Ghelardini, C; Iadonato, Sp; Mercado, Jl; Olivera, Bm; Mcintosh, Jm (2017). Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, pp. 1825-1832, ISSN:0027-8424 DOI  

  Di Cesare Mannelli, L; Lucarini, E; Micheli, L; Mosca, I; Ambrosino, P; Soldovieri, Mv; Martelli, A; Testai, L; Taglialatela, M; Calderone, V; Ghelardini, C. (2017). Effects of natural and synthetic isothiocyanate-based H2S-releasers against chemotherapy-induced neuropathic pain: Role of Kv7 potassium channels. NEUROPHARMACOLOGY, pp. 49-59, ISSN:1873-7064 DOI  

  Di Cesare Mannelli, L; Ghelardini, C. (2017). Neurorestoration from medicinal plants: an opportunity to treat painful neuropathies. NEURAL REGENERATION RESEARCH, pp. 403-404, ISSN:1673-5374 DOI  

  Chelini, A; Brogi, S; Paolino, M; Di Capua, A; Cappelli, A; Giorgi, G; Farzad, M; Di Cesare Mannelli, L; Micheli, L; Ghelardini, C; Anzini, (2017). Synthesis and Biological Evaluation of Novel Neuroprotective Pyridazine Derivatives as Excitatory Amino Acid Transporter 2 (EAAT2) Activators. JOURNAL OF MEDICINAL CHEMISTRY, pp. 5216-5221, ISSN:0022-2623 DOI  

  Di Cesare Mannelli, L; Ghelardini, C; Micheli, L; Del Bello, F; Giannella, M; Piergentili, A; Pigini, M; Quaglia, W. (2017). Synergic stimulation of serotonin 5-HT1A receptor and α2-adrenoceptors for neuropathic pain relief: Preclinical effects of 2-substituted imidazoline derivatives. EUROPEAN JOURNAL OF PHARMACOLOGY, pp. 128-133, ISSN:0014-2999 DOI  

  Micheli, L; Di Cesare Mannelli, L; Lucarini, E; Cialdai, F; Vignali, L; Ghelardini, C; Monici, M. (2017). Photobiomodulation therapy by NIR laser in persistent pain: an analytical study in the rat. LASERS IN MEDICAL SCIENCE, pp. 1835-1846, ISSN:1435-604X DOI  

  Tenci, B; Di Cesare Mannelli, L; Maresca, M; Micheli, L; Pieraccini, G; Mulinacci, N; Ghelardini, C. (2017). Effects of a water extract of Lepidium meyenii root in different models of persistent pain in rats. ZEITSCHRIFT FUR NATURFORSCHUNG. C, A JOURNAL OF BIOSCIENCES, pp. 449-457, ISSN:1865-7125 DOI  

  Di Cesare Mannelli, L; Tenci, B; Micheli, L; Vona, A; Corti, F; Zanardelli, M; Lapucci, A; Clemente, Am; Failli, P; Ghelardini, C. (2017). Adipose-derived stem cells decrease pain in a rat model of oxaliplatin-induced neuropathy: Role of VEGF-A modulation. NEUROPHARMACOLOGY, pp. 166-175, ISSN:1873-7064 DOI  

  Martino, Maria Vittoria; Guandalini, Luca; Di Cesare Mannelli, Lorenzo; Menicatti, Marta; Bartolucci, Gianluca; Dei, Silvia; Manetti, Dina; Teodori, Elisabetta; Ghelardini, Carla; Romanelli, Maria Novella (2017). Piperazines as nootropic agents: New derivatives of the potent cognition-enhancer DM235 carrying hydrophilic substituents. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 25, pp. 1795-1803, ISSN:0968-0896 DOI   Accesso ONLINE all'editore

  Cirri, Marzia; Mennini, Natascia; Maestrelli, Francesca; Mura, Paola; Ghelardini, Carla; di Cesare Mannelli, Lorenzo (2017). Development and in vivo evaluation of an innovative “Hydrochlorothiazide-in Cyclodextrins-in Solid Lipid Nanoparticles” formulation with sustained release and enhanced oral bioavailability for potential hypertension treatment in pediatrics. INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 521, pp. 73-83, ISSN:0378-5173 DOI   Accesso ONLINE all'editore

  Bua, Silvia; Di Cesare Mannelli, Lorenzo; Vullo, Daniela; Ghelardini, Carla; Bartolucci, Gianluca; Scozzafava, Andrea; Supuran, Claudiu T; Carta, Fabrizio (2017). Design and Synthesis of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Treatment of Rheumatoid Arthritis. JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, pp. 1159-1170, ISSN:0022-2623 DOI   Accesso ONLINE all'editore

  Guerrini, Gabriella; Ciciani, Giovanna; Crocetti, Letizia; Daniele, Simona; Ghelardini, Carla; Giovannoni, Maria Paola; Lorenzo Di Cesare Mannelli, ; Martini, Claudia; Vergelli, Claudia (2017). Synthesis and pharmacological evaluation of novel GABAA subtype receptor ligands with potential anxiolytic-like and anti-hyperlagesic effect. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 54, pp. 2788-2799, ISSN:1943-5193 DOI  

  Maestrelli, F; Mura, P; González-Rodríguez, Ml; Cózar-Bernal, Mj; Rabasco, Am; Di Cesare Mannelli, L; Ghelardini, C. (2017). Calcium alginate microspheres containing metformin hydrochloride niosomes and chitosomes aimed for oral therapy of type 2 diabetes mellitus. INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 530, pp. 430-439, ISSN:0378-5173 DOI   Accesso ONLINE all'editore

  Lorenzo Di Cesare Mannelli, ; Mario, Maresca; Laura, Micheli; Carlo, Farina; Michael, W; Carla, Ghelardini (2017). A rat model of FOLFOX-induced neuropathy: effects of oral dimiracetam in comparison with duloxetine and pregabalin. CANCER CHEMOTHERAPY AND PHARMACOLOGY, pp. 1091-1103, ISSN:0344-5704 DOI  

  Di Cesare Mannelli, Lorenzo; Micheli, Laura; Crocetti, Letizia; Giovannoni, Maria Paola; Vergelli, Claudia; Ghelardini, Carla (2017). α2 Adrenoceptor: a Target for Neuropathic Pain Treatment. MINI-REVIEWS IN MEDICINAL CHEMISTRY, vol. 16, pp. 95-107, ISSN:1875-5607 DOI  

  Falsini, Matteo; Squarcialupi, Lucia; Catarzi, Daniela; Varano, Flavia; Betti, Marco; Di Cesare Mannelli, Lorenzo; Tenci, Barbara; Ghelardini, Carla; Tanc, Muhammet; Angeli, Andrea; Supuran, Claudiu T.; Colotta, Vittoria (2017). 3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold to Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII. JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, pp. 6428-6439, ISSN:0022-2623 DOI   Accesso ONLINE all'editore

  Di Cesare Mannelli, Lorenzo; Zanardelli, Matteo; Landini, Ida; Pacini, Alessandra; Ghelardini, Carla; Mini, Enrico; Bencini, Andrea; Valtancoli, Barbara; Failli, Paola (2016). Effect of the SOD mimetic MnL4 on in vitro and in vivo oxaliplatin toxicity: Possible aid in chemotherapy induced neuropathy. FREE RADICAL BIOLOGY & MEDICINE, vol. 93, pp. 67-76, ISSN:0891-5849 DOI  

  Consalvi, Sara; Poce, Giovanna; Ragno, Rino; Sabatino, Manuela; Lamotta, Concettina; Sartini, Stefania; Calderone, Vincenzo; Martelli, Alma; Ghelardini, Carla; DI CESARE MANNELLI, Lorenzo; Biava, Mariangela (2016). A Series of COX-2 Inhibitors Endowed with NO-Releasing Properties: Synthesis, Biological Evaluation, and Docking Analysis. CHEMMEDCHEM, vol. 11, pp. 1804-1811, ISSN:1860-7179 DOI   Accesso ONLINE all'editore

  Roselli, Mariagrazia; Carocci, Alessia; Budriesi, Roberta; Micucci, Matteo; Toma, Maddalena; Di Cesare Mannelli, Lorenzo; Lovece, Angelo; Catalano, Alessia; Cavalluzzi, Maria Maddalena; Bruno, Claudio; De Palma, Annalisa; Contino, Marialessandra; Perrone, Maria Grazia; Colabufo, Nicola Antonio; Chiarini, Alberto; Franchini, Carlo; Ghelardini, Carla; Habtemariam, Solomon; Lentini, Giovanni (2016). Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 121, pp. 300-307, ISSN:0223-5234 DOI  

  Pacini, A; Micheli, L; Maresca, M; Branca, Jj; Mcintosh, Jm; Ghelardini, C; Di Cesare Mannelli, L. (2016). The α9α10 nicotinic receptor antagonist α-conotoxin RgIA prevents neuropathic pain induced by oxaliplatin treatment.. EXPERIMENTAL NEUROLOGY, vol. 282, pp. 37-48, ISSN:0014-4886 DOI  

  Brindisi, Margherita; Maramai, Samuele; Gemma, Sandra; Brogi, Simone; Grillo, Alessandro; Di Cesare Mannelli, Lorenzo; Gabellieri, Emanuele; Lamponi, Stefania; Saponara, Simona; Gorelli, Beatrice; Tedesco, Daniele; Bonfiglio, Tommaso; Landry, Christophe; Jung, Kwang-Mook; Armirotti, Andrea; Luongo, Livio; Ligresti, Alessia; Piscitelli, Fabiana; Bertucci, Carlo; Dehouck, Marie-Pierre; Campiani, Giuseppe; Maione, Sabatino; Ghelardini, Carla; Pittaluga, Anna; Piomelli, Daniele; Di Marzo, Vincenzo; Butini, Stefania (2016). Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain. JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, pp. 2612-2632, ISSN:0022-2623 DOI   Accesso ONLINE all'editore

  Di Cesare Mannelli, Lorenzo; Micheli, Laura; Maresca, Mario; Cravotto, Giancarlo; Bellumori, Maria; Innocenti, Marzia; Mulinacci, Nadia; Ghelardini, Carla (2016). Anti-neuropathic effects of Rosmarinus officinalis L. terpenoid fraction: Relevance of nicotinic receptors. SCIENTIFIC REPORTS, vol. 6, pp. 1-15, ISSN:2045-2322 DOI  

  Betti, M.; Colotta, V.; Varano, F.; Falsini, M.; Varani, K.; Vincenzi, F.; Dal Ben, D.; Di Cesare Mannelli, L.; Zanardelli, M.; Bartolucci, G.; Menicatti, M.; Catarzi, D. (2016). Aminopyridine-3,5-carbonitrile core for the design of new adenosine receptor agonists: structural exploration to target the A1 subtype. In: XXIV National Meeting on Medicinal Chemistry, 10th Young Medicinal Chemists’ Symposium, 11-14 settembre 2016, Perugia., d, pp. 108-108.

  Gonçalves, L.M.D.; Maestrelli, F; Di Cesare Mannelli, L.; Ghelardini, C.; Almeida, A.J.; Mura, P. (2016). Development of solid lipid nanoparticles as carriers for improving oral bioavailability of glibenclamide. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 102, pp. 41-50, ISSN:0939-6411 DOI   Accesso ONLINE all'editore

  Bird, Mark F.; Camilla Cerlesi, Maria; Brown, Mark; Malfacini, Davide; Vezzi, Vanessa; Molinari, Paola; Micheli, Laura; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Guerrini, Remo; Calò, Girolamo; Lambert, David G. (2016). Characterisation of the novel mixed Mu-NOP peptide ligand dermorphin-N/OFQ (DeNo). PLOS ONE, vol. 11 - e0156897, pp. 1-22, ISSN:1932-6203 DOI   Accesso ONLINE all'editore

  Bianchi, Enrica; Di Cesare Mannelli, Lorenzo; Micheli, Laura; Farzad, Mersedez; Aglianò, Margherita; Ghelardini, Carla (2016). Apoptotic Process Induced by Oxaliplatin in Rat Hippocampus Causes Memory Impairment. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, pp. 1-8, ISSN:1742-7835 DOI   Accesso ONLINE all'editore

  Del Bello, Fabio; Cilia, Antonio; Carrieri, Antonio; Fasano, Domenico Claudio; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo; Micheli, Laura; Santini, Carlo; Diamanti, Eleonora; Giannella, Mario; Giorgioni, Gianfabio; Mammoli, Valerio; Paoletti, Corinne Dalila; Petrelli, Riccardo; Piergentili, Alessandro; Quaglia, Wilma; Pigini, Maria (2016). The Versatile 2-Substituted Imidazoline Nucleus as a Structural Motif of Ligands Directed to the Serotonin 5-HT1A Receptor. CHEMMEDCHEM, vol. 11, pp. 2287-2298, ISSN:1860-7179 DOI   Accesso ONLINE all'editore

  Maresca, Mario; Micheli, Laura; Di Cesare Mannelli, Lorenzo; Tenci, Barbara; Innocenti, Marzia; Khatib, Mohamad; Mulinacci, Nadia; Ghelardini, Carla (2016). Acute effect of Capparis spinosa root extracts on rat articular pain. JOURNAL OF ETHNOPHARMACOLOGY, vol. 193, pp. 456-465, ISSN:0378-8741 DOI   Accesso ONLINE all'editore

  Grassi, Giacomo; Laura, Micheli; Lorenzo, Di Cesare Mannelli; Elisa, Compagno; Lorenzo, Righi; Carla, Ghelardini; Stefano, Pallanti (2016). Atomoxetine for hoarding disorder: A pre-clinical and clinical investigation. JOURNAL OF PSYCHIATRIC RESEARCH, vol. 83, pp. 240-248, ISSN:0022-3956 DOI   Accesso ONLINE all'editore

  Testai, Lara; Marino, Alice; Piano, Ilaria; Brancaleone, Vincenzo; Tomita, Kengo; Di Cesare Mannelli, Lorenzo; Martelli, Alma; Citi, Valentina; Breschi, Maria C.; Levi, Roberto; Gargini, Claudia; Bucci, Mariarosaria; Cirino, Giuseppe; Ghelardini, Carla; Calderone, Vincenzo (2016). The novel H2S-donor 4-carboxyphenyl isothiocyanate promotes cardioprotective effects against ischemia/reperfusion injury through activation of mitoKATP channels and reduction of oxidative stress. PHARMACOLOGICAL RESEARCH, vol. 113, pp. 290-299, ISSN:1043-6618 DOI   Accesso ONLINE all'editore

  Di Cesare Mannelli, L; Micheli, L; Cinci, L; Maresca, M; Vergelli, C; Pacini, A; Quinn, M.T.; Giovannoni, M. P.; Ghelardini, C. (2016). Effects of the neutrophil elastase inhibitor EL-17 in rat adjuvant-induced arthritis.. RHEUMATOLOGY, vol. 55, pp. 1285-1294, ISSN:1462-0332 DOI  

  Di Capua, Angela; Sticozzi, Claudia; Brogi, Simone; Brindisi, Margherita; Cappelli, Andrea; Sautebin, Lidia; Rossi, Antonietta; Pace, Simona; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo; Valacchi, Giuseppe; Giorgi, Gianluca; Giordani, Antonio; Poce, Giovanna; Biava, Mariangela; Anzini, Maurizio (2016). Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 109, pp. 99-106, ISSN:0223-5234 DOI   Accesso ONLINE all'editore

  Tayebati, Seyed Khosrow; Tomassoni, Daniele; Di Cesare Mannelli, Lorenzo; Amenta, Francesco (2016). Effect of treatment with the antioxidant alpha-lipoic (thioctic) acid on heart and kidney microvasculature in spontaneously hypertensive rats. CLINICAL AND EXPERIMENTAL HYPERTENSION, vol. 38, pp. 30-38, ISSN:1064-1963 DOI  

  Cappelli, Andrea; Anzini, Maurizio; Castriconi, Federica; Grisci, Giorgio; Paolino, Marco; Braile, Carlo; Valenti, Salvatore; Giuliani, Germano; Vomero, Salvatore; Di Capua, Angela; Betti, Laura; Giannaccini, Gino; Lucacchini, Antonio; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo; Frosini, Maria; Ricci, Lorenzo; Giorgi, Gianluca; Mascia, Maria Paola; Biggio, Giovanni (2016). Design, Synthesis, and Biological Evaluation of Imidazo[1,5-a]quinoline as Highly Potent Ligands of Central Benzodiazepine Receptors. JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, pp. 3353-3372, ISSN:0022-2623 DOI   Accesso ONLINE all'editore

  Di Cesare Mannelli, Lorenzo; Marcoli, Manuela; Micheli, Laura; Zanardelli, Matteo; Maura, Guido; Ghelardini, Carla; Cervetto, Chiara (2015). Oxaliplatin evokes P2X7-dependent glutamate release in the cerebral cortex: A pain mechanism mediated by Pannexin 1. NEUROPHARMACOLOGY, vol. 97, pp. 133-41-141, ISSN:0028-3908 DOI  

  Ghelardini, Carla; Di Cesare Mannelli, Lorenzo; Bianchi, Enrica (2015). The pharmacological basis of opioids. CLINICAL CASES IN MINERAL AND BONE METABOLISM, vol. 12, pp. 219-221, ISSN:1724-8914 DOI  

  Micheli, Laura; Di Cesare Mannelli, Lorenzo; Rizzi, Anna; Guerrini, Remo; Trapella, Claudio; Calò, Girolamo; Ghelardini, Carla (2015). Intrathecal administration of nociceptin/orphanin FQ receptor agonists in rats: A strategy to relieve chemotherapy-induced neuropathic hypersensitivity. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 766, pp. 155-162, ISSN:0014-2999 DOI   Accesso ONLINE all'editore

  Di Cesare Mannelli, Lorenzo; Micheli, Laura; Carta, Fabrizio; Cozzi, Andrea; Ghelardini, Carla; Supuran, Claudiu T (2015). Carbonic anhydrase inhibition for the management of cerebral ischemia: in vivo evaluation of sulfonamide and coumarin inhibitors. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, pp. 1-6, ISSN:1475-6366 DOI  

  Di Cesare Mannelli, Lorenzo; Tenci, Barbara; Zanardelli, Matteo; Maidecchi, Anna; Lugli, Andrea; Mattoli, Luisa; Ghelardini, Carla (2015). Widespread pain reliever profile of a flower extract of Tanacetum parthenium. PHYTOMEDICINE, vol. 22, pp. 752-758, ISSN:0944-7113 DOI   Accesso ONLINE all'editore

  Mennini, Natascia; Mura, Paola; Nativi, Cristina; Richichi, Barbara; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla (2015). Injectable liposomal formulations of opiorphin as a new therapeutic strategy in pain management. FUTURE SCIENCE OA, vol. 1, pp. 1-10, ISSN:2056-5623 Accesso ONLINE all'editore

  Gualdani, R.; Cerruti, S.; Magni, G.; Merli, D.; Di Cesare Mannelli, L.; Francesconi, O.; Richichi, B.; la Marca, G.; Ghelardini, C.; Moncelli, M.R.; Nativi, C. (2015). Lipoic-Based TRPA1/TRPV1 Antagonist to Treat Orofacial Pain. ACS CHEMICAL NEUROSCIENCE, vol. 6, pp. 380-385, ISSN:1948-7193 DOI  

  Nistri, S; Di Cesare Mannelli, L; Ghelardini, C; Zanardelli, M; Bani, D; Failli, P. (2015). Pretreatment with relaxin does not restore no-mediated modulation of calcium signal in coronary endothelial cells isolated from spontaneously hypertensive rats. MOLECULES, vol. 20, pp. 9524-9535, ISSN:1420-3049 DOI   Accesso ONLINE all'editore

  Cinci, Lorenzo; Corti, Francesca; Di Cesare Mannelli, Lorenzo; Micheli, Laura; Zanardelli, Matteo; Ghelardini, Carla (2015). Oxidative, Metabolic, And Apoptotic Responses of Schwann Cells to High Glucose Levels. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, vol. 29, pp. 274-279, ISSN:1095-6670 DOI   Accesso ONLINE all'editore

  Nistri, Silvia; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Zanardelli, Matteo; Bani, Daniele; Failli, Paola (2015). Pretreatment with Relaxin Does Not Restore NO-Mediated Modulation of Calcium Signal in Coronary Endothelial Cells Isolated from Spontaneously Hypertensive Rats. MOLECULES, vol. 20, pp. 9524-9535, ISSN:1420-3049 DOI  

  Di Cesare Mannelli, Lorenzo; Micheli, Laura; Ghelardini, Carla (2015). Nociceptin/orphanin FQ receptor and pain: Feasibility of the fourth opioid family member. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 766, pp. 151-4-154, ISSN:0014-2999 DOI  

  Di Cesare Mannelli, Lorenzo; Zanardelli, Matteo; Bartolucci, Gianluca; Karioti, Anastasia; Bilia, Anna Rita; Vannacci, Alfredo; Mugelli, Alessandro; Ghelardini, Carla (2015). In Vitro Evidence for the Use of Astragali Radix Extracts as Adjuvant against Oxaliplatin-Induced Neurotoxicity. PLANTA MEDICA, vol. 81, pp. 1045-1055, ISSN:0032-0943 DOI   Accesso ONLINE all'editore

  Morucci G; Branca JJV; Gulisano M; Ruggiero M; Paternostro F; Pacini A; Di Cesare Mannelli L; Pacini S (2015). Gc-protein-derived macrophage activating factor counteracts the neuronal damage induced by oxaliplatin. ANTI-CANCER DRUGS, vol. 26(2), pp. 197-209, ISSN:0959-4973 DOI  

  Di Cesare Mannelli, Lorenzo; Pacini, Alessandra; Corti, Francesca; Boccella, Serena; Luongo, Livio; Esposito, Emanuela; Cuzzocrea, Salvatore; Maione, Sabatino; Calignano, Antonio; Ghelardini, Carla (2015). Antineuropathic profile of N-palmitoylethanolamine in a rat model of oxaliplatin-induced neurotoxicity. PLOS ONE, vol. 10, pp. e0128080-e128104, ISSN:1932-6203 DOI  

  Di Cesare Mannelli, Lorenzo; Corti, Francesca; Micheli, Laura; Zanardelli, Matteo; Ghelardini, Carla (2015). Delay of morphine tolerance by palmitoylethanolamide. BIOMED RESEARCH INTERNATIONAL, vol. 2015, pp. 1-12, ISSN:2314-6133 DOI   Accesso ONLINE all'editore

  Carta, Fabrizio; Di Cesare Mannelli, Lorenzo; Pinard, Melissa; Ghelardini, Carla; Scozzafava, Andrea; Mckenna, Robert; Supuran, Claudiu T. (2015). A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 23, pp. 1828-1840, ISSN:0968-0896 DOI   Accesso ONLINE all'editore

  Guandalini, Luca; Martino, Maria Vittoria; Di Cesare Mannelli, Lorenzo; Bartolucci, Gianluca; Melani, Fabrizio; Malik, Ruchi; Dei, Silvia; Floriddia, Elisa; Manetti, Dina; Orlandi, Francesca; Teodori, Elisabetta; Ghelardini, Carla; Romanelli, Maria Novella (2015). Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the cognition-enhancer DM235. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 25, pp. 1700-1704, ISSN:0960-894X DOI  

  Grandane, Aiga; Tanc, Muhammet; Di Cesare Mannelli, Lorenzo; Carta, Fabrizio; Ghelardini, Carla; Žalubovskis, Raivis; Supuran, Claudiu T. (2015). 6-substituted sulfocoumarins are selective carbonic anhdydrase IX and XII Inhibitors with significant cytotoxicity against colorectal cancer cells. JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, pp. 3975-3983, ISSN:0022-2623 DOI   Accesso ONLINE all'editore

  Squarcialupi, L.; Falsini, M.; Catarzi, D.; Varano, F.; Betti, M.; Di Cesare Mannelli, L.; Zanardelli, M.; Ghelardini, C.; Tanc, M.; Supuran, C.T.; Colotta, V. (2015). 3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new potent and selective inhibitors of the tumor-associated carbonic anhydrase IX and XII.. In: XXIII National Meeting on Medicinal Chemistry, 6-9 settembre 2015, Salerno., d, pp. 131-131.

  Martino, M. V.; DI CESARE MANNELLI, L. ; Bartolucci, G.; S, . DEI; Manetti, D.; Ghelardini, C.; Teodori, E.; Romanelli, M. N. (2015). 2- or 3-Substituted piperazines as nootropic agents: carbethoxy and hydroxymethyl analogues of the cognition-enhancer DM235. In: XXIII National Meeting on Medicinal Chemistry and 9th Young Medicinal Chemists Symposium (XXIII NMMC – 9th NPCF), Salerno, 6-9 settembre 2015, Edizioni Ziino, pp. 136-136.

  Di Cesare Mannelli, Lorenzo; Tenci, Barbara; Zanardelli, Matteo; Failli, Paola; Ghelardini, Carla (2015). α7 Nicotinic Receptor Promotes the Neuroprotective Functions of Astrocytes against Oxaliplatin Neurotoxicity. NEURAL PLASTICITY, vol. 2015, pp. 396908-396917, ISSN:2090-5904 DOI   Accesso ONLINE all'editore

  Betti, Marco; Catarzi, Daniela; Varano, Flavia; Varani, Katia; Lorenzo Di Cesare Mannelli, ; Zanardelli, M.; Ghelardini, Carla; Colotta, Vittoria . (2015). Aminopyridine-3,5-dicarbonitriles as non-nucleoside adenosine A1 receptor agonists.. In: XXIII National Meeting on Medicinal Chemistry, 6-9 settembre 2015, Salerno., d, pp. 132-132.

  Di Cesare Mannelli, Lorenzo; Maresca, Mario; Farina, Carlo; Scherz, Michael W; Ghelardini, Carla (2015). A model of neuropathic pain induced by sorafenib in the rat: Effect of dimiracetam. NEUROTOXICOLOGY, vol. 50, pp. 101-7-107, ISSN:0161-813X DOI   Accesso ONLINE all'editore

  Ghelardini, C; Di Cesare Mannelli, L.; Cerretani, D.; Bianchi, E. (2015). GLUTAMATERGIC SYSTEM MODULATORS AS AGENTS IN PREVENTION AND MANAGEMENT OF CHEMOTHERAPY- INDUCED POLYNEUROPATHY. THERAPEUTIC TARGETS FOR NEUROLOGICAL DISEASES, vol. 2:e672, pp. 1-3, ISSN:2376-0478 DOI  

  Zanardelli, Matteo; Micheli, Laura; Nicolai, Raffaella; Failli, Paola; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo (2015). Different apoptotic pathways activated by oxaliplatin in primary astrocytes vs. colo-rectal cancer cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 16, pp. 5386-5399, ISSN:1661-6596 DOI   Accesso ONLINE all'editore

  Micheli, Laura; Di Cesare Mannelli, Lorenzo; Guerrini, Remo; Trapella, Claudio; Zanardelli, Matteo; Ciccocioppo, Roberto; Rizzi, Anna; Ghelardini, Carla; Calò, Girolamo (2015). Acute and subchronic antinociceptive effects of nociceptin/orphanin FQ receptor agonists infused by intrathecal route in rats. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 754, pp. 73-81, ISSN:0014-2999 DOI   Accesso ONLINE all'editore

  Consalvi, Sara; Alfonso, Salvatore; Di Capua, Angela; Poce, Giovanna; Pirolli, Adele; Sabatino, Manuela; Ragno, Rino; Anzini, Maurizio; Sartini, Stefania; La Motta, Concettina; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Biava, Mariangela (2015). Synthesis, biological evaluation and docking analysis of a new series of methylsulfonyl and sulfamoyl acetamides and ethyl acetates as potent COX-2 inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 23, pp. 810-820, ISSN:0968-0896 DOI   Accesso ONLINE all'editore

  M. P. Giovannoni;G. Ciciani;A. Cilibrizzi;L. Crocetti;S. Daniele;L. Di Cesare Mannelli;C. Ghelardini;C. Giacomelli;G. Guerrini;C. Martini;M. L. Trincavelli;C. Vergelli (2015). Further studies on pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective human A1 adenosine receptor antagonists.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 89, pp. 32-41, ISSN:0223-5234 DOI   Accesso ONLINE all'editore

  Ghelardini, Carla; Di Cesare Mannelli, Lorenzo (2015). Composizioni atte a favorire il miglioramento delle prestazioni intellettuali. Numero: MI2015A000549 Ghelardini Carla, Di Cesare Mannelli Lorenzo

  Gualdani, Roberta; Ceruti, Stefania; Magni, Giulia; Merli, Davide; di Cesare Mannelli, Lorenzo; Francesconi, Oscar; Richichi, Barbara; la Marca, Giancarlo; Ghelardini, Carla; Moncelli, Maria Rosa; Nativi, Cristina (2015). The Role of TRPA1 and TRPV1 Channels in Orofacial Pain. BIOPHYSICAL JOURNAL, vol. 108, pp. 123a-123a, ISSN:0006-3495 DOI  

  Claudia Vergelli; Giovanna Ciciani; Agostino Cilibrizzi; Letizia Crocetti; Lorenzo Di Cesare Mannelli; Carla Ghelardini; Gabriella Guerrini; Antonella Iacovone; Maria Paola Giovannoni (2015). Synthesis of five and six-membered heterocycles bearing an arylpiperazinylalkyl side chain as orally active antinociceptive agents. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 23, pp. 6237-6245, ISSN:0968-0896

  Zanardelli, M; Micheli, L; Cinci, L; Failli, P; Ghelardini, C; Di Cesare Mannelli, L (2014). Oxaliplatin Neurotoxicity Involves Peroxisome Alterations. PPARc Agonism as Preventive Pharmacological Approach. PLOS ONE, vol. 9, pp. 0-0, ISSN:1932-6203 DOI  

  Di Cesare Mannelli L; Cinci L; Micheli L; Zanardelli M; Pacini A; McIntosh JM; Ghelardini C (2014). alpha-Conotoxin RgIA protects against the development of nerve injury-induced chronic pain and prevents both neuronal and glial derangement.. PAIN, vol. 155, pp. 1986-1995, ISSN:0304-3959 DOI  

  Biava M; Battilocchio C; Poce G; Alfonso S; Consalvi S; Di Capua A; Calderone V; Martelli A; Testai L; Sautebin L; Rossi A; Ghelardini C; Di Cesare Mannelli L; Giordani A; Persiani S; Colovic M; Dovizio M; Patrignani P; Anzini M (2014). Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 22, pp. 772-786, ISSN:0968-0896 DOI  

  Pacini A; Micheli L; Di Cesare Mannelli L; Mugelli A; Ghelardini C (2014). Astragalus membranaceus and oxaliplatin-induced neuropathy: pain relief and prevention of nervous tissue modifications.. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 119, pp. 147-147, ISSN:1122-6714

  Jacopo J.V. Branca; Gabriele Morucci; Massimo Gulisano; Marco Ruggiero; Ferdinando Paternostro; Alessandra Pacini; Lorenzo Di Cesare Mannelli; Stefania Pacini (2014). Human and murine microglial cell lines: two experimental models to deeply understand the mechanism of microglia involvement in human brain diseases. In: 68° Congresso della Società Italiana di Anatomia e Istologia, Ancona, 18-20 Settembre, Firenze University Press, vol. 119 (1 Supplement), pp. 21-21.

  Pallanti, Stefano; Tofani, Tommaso; Zanardelli, Matteo; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla (2014). BDNF and ARTEMIN are increased in drug-naïve non-depressed GAD patients: Preliminary data. INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE, vol. 18, pp. 255-260, ISSN:1365-1501 DOI   Accesso ONLINE all'editore

  Fariello RG; Ghelardini C; Di Cesare Mannelli L; Bonanno G; Pittaluga A; Milanese M; Misiano P; FArina C (2014). Broad spectrum and prolonged efficacy of dimiracetam in models of neuropathic pain. NEUROPHARMACOLOGY, vol. 81, pp. 85-94, ISSN:0028-3908 DOI  

  Bianchi E; Di Cesare Mannelli L; Menicacci C; Lorenzoni P; Aglianò M; Ghelardini C (2014). Prophylactic role of acetyl-L-carnitine on knee lesions and associated pain in a rat model of osteoarthritis. LIFE SCIENCES, vol. 106, pp. 32-39, ISSN:0024-3205 DOI  

  Gabriele Morucci; Jacopo J.V. Branca; Massimo Gulisano; Marco Ruggiero; Ferdinando Paternostro; Alessandra Pacini; Lorenzo Di Cesare Mannelli; Stefania Pacini (2014). Gc-protein derived macrophage activating factor (GcMAF) counteracts the neuronal damage induced by oxaliplatin. In: 68° Congresso della Società Italiana di Anatomia e Istologia, Ancona, 18-20 Settembre 2014, Firenze University Press, vol. 119 (1 Supplement), pp. 135-135.

  Baptista-De Souza D; Di Cesare Mannelli L; Zanardelli M; Micheli L; Nunes-De Souza RL; Canto-De Souza A; Ghelardini C (2014). Serotonergic modulation in neuropathy induced by oxaliplatin: Effect on the 5HT2C receptor. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 735, pp. 141-149, ISSN:0014-2999 DOI  

  Natascia Mennini; Sandra Furlanetto; Marco Bragagni; Carla Ghelardini; Lorenzo Di Cesare Mannelli; Paola Mura (2014). Development of a chitosan-derivative micellar formulation to improve celecoxib asolubility and bioavailability. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, vol. 40, pp. 1494-1502, ISSN:0363-9045 DOI   Accesso ONLINE all'editore

  L. Cinci;L. Di Cesare Mannelli;M. Zanardelli;L. Micheli;D. Guasti;C. Ghelardini (2014). Peroxisome determination in optical microscopy: a useful tool derived by a simplification of an old ultrastructural technique.. ACTA HISTOCHEMICA, vol. 116, pp. 863-870, ISSN:0065-1281 DOI   Accesso ONLINE all'editore

  Elvira Fantechi;Claudia Innocenti;Matteo Zanardelli;Maria Fittipaldi;Elisabetta Falvo;Miriam Carbo;Valbona Shullani;Lorenzo Di Cesare Mannelli;Carla Ghelardini;Anna Maria Ferretti;Alessandro Ponti;Claudio Sangregorio;Pierpaolo Ceci (2014). A Smart Platform for Hyperthermia Application in Cancer Treatment: Cobalt-Doped Ferrite Nanoparticles Mineralized in Human Ferritin Cages. ACS NANO, vol. 8, pp. 4705-4719, ISSN:1936-0851 DOI  

  Bellumori Maria; Marzia Innocenti; Giancarlo Cravotto; Lorenzo Di Cesare Mannelli; Carla Ghelardini; Nadia Mulinacci (2014). Protective action of Rosemary extracts obtained by green innovative techniques on neuropathic pain. In: X Congresso Nazioanle di Chimica degli Alimenti, Firenze, 6-10 Luglio 2014, Nadia Mulinacci,Marzia Innocenti, vol. 1, pp. 35-35, ISBN:9788894004304

  Di Cesare Mannelli, Lorenzo; Ghelardini, Carla (2014). Using palmitoylethanolamide in combination with opioids. Numero: Italia: MI2014A000876; USA: US 2015/0328173 A1 F. DELLA VALLE, M.F. DELLA VALLE, L. DI CESARE MANNELLI, C. GHELARDINI. EPITECH

  Di Cesare Mannelli L.; Pacini A.; Micheli L.; Tani A.; Zanardelli M.; Ghelardini C. (2014). Glia role in oxaliplatin-induced neuropathic pain.. EXPERIMENTAL NEUROLOGY, vol. 261C, pp. 22-33, ISSN:0014-4886 DOI  

  Di Cesare Mannelli L.; Pacini A.; De Amici M.; Matera C:; Zanardelli M.; Mello T.; Dallanoce C.; Ghelardini C. (2014). Involvement of alpha7 nAChR subtype in rat oxaliplatin-induced neuropathy: effects of selective activation.. NEUROPHARMACOLOGY, vol. 79, pp. 37-48, ISSN:0028-3908 DOI  

  Di Cesare Mannelli, L; Zanardelli, M; Micheli, L; Ghelardini, C (2014). PPAR-γ Impairment Alters Peroxisome Functionality in Primary Astrocyte Cell Cultures. BIOMED RESEARCH INTERNATIONAL, pp. 0-0, ISSN:2314-6141 DOI  

  Nativi, Cristina; Gualdani, R; Dragoni, Elisa; DI CESARE MANNELLI, Lorenzo; Sostegni, S; Norcini, M; Gabrielli, G; LA MARCA, Giancarlo; Richichi, Barbara; Francesconi, Oscar; Moncelli, MARIA ROSA; Ghelardini, Carla; Roelens, Stefano (2013). A TRPA1 antagonist reverts oxaliplatin-induced neuropathic pain. SCIENTIFIC REPORTS, vol. 3, pp. 1-10, ISSN:2045-2322 DOI  

  Tomassoni D.; Amenta F.; Di cesare Mannelli L.; Ghelardini C.; Nwankwo IE.; Pacini A.; Tayebaty SK. (2013). Neuroprotective activity of thioctic acid in central nervous system lesions consequent to peripheral nerve injury.. BIOMED RESEARCH INTERNATIONAL, vol. 2013 Article ID985093, pp. 1-14, ISSN:2314-6133 DOI   Accesso ONLINE all'editore

  Battilocchio C; Guetzoyan L; Cervetto C; Di Cesare Mannelli L; Frattaroli D; Baxendale IR; Maura G; Rossi A; Sautebin L; Biava M; Ghelardini C; Marcoli M; Ley SV (2013). Flow Synthesis and Biological Studies of an Analgesic Adamantane Derivative That Inhibits P2X7‐Evoked Glutamate Release. ACS MEDICINAL CHEMISTRY LETTERS, vol. 4, pp. 704-709, ISSN:1948-5875 DOI  

  D. Catarzi; F. Varano; V. Colotta; L. Squarcialupi; R. Matucci; L. di Cesare Mannelli; M.Zanardelli (2013). Synthesis and Pharmacological evaluation of some new 8-substitute-7-trifluoromethyl-4,5-dihydro-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates as AMPA/Kainate receptor antagonists. In: 22st National Meeting on Medicinal Chemistry, Roma, 10-13 september 20013, d, pp. P.CD.03-P. CD. 03.

  Di Cesare Mannelli L; Zanardelli M; Failli P; Ghelardini C (2013). Oxaliplatin-induced oxidative stress in nervous system-derived cellular models: Could it correlate with in vivo neuropathy?. FREE RADICAL BIOLOGY & MEDICINE, vol. 61, pp. 143-150, ISSN:0891-5849 DOI  

  Battilocchio C; Poce G; Alfonso S; Porretta GC; Consalvi S; Sautebin L; Pace S; Rossi A; Ghelardini C; Di Cesare Mannelli L; Schenone S; Giordani A; Di Francesco L; Patrignani P; Biava M (2013). A class of pyrrole derivatives endowed with analgesic/anti- inflammatory activity. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, pp. 3695-3701, ISSN:0968-0896 DOI  

  Di Cesare Mannelli L; Micheli L; Zanardelli M; Ghelardini C (2013). Low dose native type II collagen prevents pain in a rat osteoarthritis model. BMC MUSCULOSKELETAL DISORDERS, vol. 14, pp. 228-235, ISSN:1471-2474 DOI  

  Carrino D; Tani A; Di Cesare Mannelli L; Sgambati E; Ghelardini C; Pacini A (2013). Glia inhibition suppress chemotherapy-induced neuropathic pain in the rat.. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 118, pp. 48-48, ISSN:1122-6714

  Di Cesare Mannelli L; Zanardelli M; Ghelardini C (2013). Nicotine is a pain reliever in trauma- and chemotherapy-induced neuropathy models. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 711, pp. 87-94, ISSN:0014-2999 DOI  

  Anzini M; Di Capua A; Valenti S; Brogi S; Rovini M; Giuliani G; Cappelli A; Vomero S; Chiasserini L; Sega A; Poce G; Giorgi G; Calderone V; Martelli A; Testai L; Sautebin L; Rossi A; Pace G; Ghelardini C; Di Cesare Mannelli L; Benetti V; Giordani A; Anzellotti P; Dovizio M; Patrignani P; Biava M (2013). Novel Analgesic/Anti-Inflammatory Agents: 1,5-Diarylpyrrole Nitrooxyalkyl Ethers and Related Compounds as Cyclooxygenase‐2 Inhibiting Nitric Oxide Donors. JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, pp. 3191-3206, ISSN:1520-4804 DOI  

  Tomassoni, Daniele; Amenta, Francesco; Amantini, Consuelo; Farfariello, Valerio; Di Cesare Mannelli, Lorenzo; Nwankwo, Innocent E; Marini, Carlotta; Tayebati, Seyed Khosrow (2013). Brain activity of thioctic Acid enantiomers: in vitro and in vivo studies in an animal model of cerebrovascular injury. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 14, pp. 4580-4595, ISSN:1422-0067 DOI  

  L. Di Cesare Mannelli; D. Bani; A. Bencini; M.L. Brandi; L. Calosi; M. Cantore; A.M. Carossino; C. Ghelardini; B. Valtancoli; P. Failli (2013). Therapeutic Effects of the Superoxide Dismutase Mimetic Compound Mn(II)Me2DO2A on Experimental Articular Pain in Rats.. MEDIATORS OF INFLAMMATION, vol. 2013, pp. 1-12, ISSN:0962-9351 DOI   Accesso ONLINE all'editore

  R. Smith; L. Thyer; E. Ward; E. Meacci; J.J.V. Branca; G. Morucci; M. Gulisano; M. Ruggiero; A. Pacini; F. Paternostro;L. Di Cesare Mannelli; D. Noakes; S. Pacini (2013). Effects of Gc-macrophage activating factor in human neurons: implications for treatment of chronic fatigue syndrome. AMERICAN JOURNAL OF IMMUNOLOGY, vol. 9, pp. 120-129, ISSN:1553-619X DOI  

  Di Cesare Mannelli L.; Pacini A.; Bonaccini L.; Zanardelli M.; Mello T.; Ghelardini C. (2013). Morphological features and glial activation in oxaliplatin-dependent neuropathic pain.. THE JOURNAL OF PAIN, vol. 14, pp. 1585-1600, ISSN:1526-5900 DOI  

  Gabriella Guerrini; Giovanna Ciciani; Annarella Costanzo; Simona Daniele; Caludia Martini; Carla Ghelardini; Lorenzo Di Cesare Mannelli. (2013). Synthesis of novel cognition enhancer with pyrazolo[5,1-c][1,2,4]benzotriazine core acting at gamma-aminobutyric acid type A (GABAA) receptor.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, pp. 2186-2198, ISSN:1464-3391 DOI  

  Lucia Squarcialupi;Vittoria Colotta;Daniela Catarzi;Flavia Varano;Guido Filacchioni;Katia Varani;Carmen Corciulo;Fabrizio Vincenzi;Pier Andrea Borea;Carla Ghelardini;Lorenzo Di Cesare Mannelli;Antonella Ciancetta;Stefano Moro (2013). 2-Arylpyrazolo[4,3-d]pyrimidin-7-amino Derivatives As New Potent and Selective Human A3Adenosine Receptor Antagonists. Molecular Modeling Studies and Pharmacological Evaluation. JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, pp. 2256-2269, ISSN:0022-2623 DOI  

  Di Cesare Mannelli L.; D'Agostino G.; Pacini A.; Russo R.; Zanardelli M.; Ghelardini C.; Calignano A. (2013). Palmitoylthanolamide is a disease-modifying agent in peripheral neuropathy: pain relief and neuroprotection share a PPAR-apha-mediated mechanism.. MEDIATORS OF INFLAMMATION, vol. Article ID 328797, pp. 1-12, ISSN:1466-1861 DOI  

  L. Squarcialupi; V. Colotta; D. Catarzi; F. Varano; K. Varani; C. Corciulo; F. Vincenzi; A. Ciancetta; L. Di Cesare Mannelli; C. Ghelardini; S. Moro (2013). Arilpirazolo[4,3-d]pirimidin-7-ammino derivati quali nuovi antagonisti potenti e selettivi del recettore umano A3 dell’adenosina. In: TUMA 2013, Sesto Fiorentino (FI), 1-2-Luglio 2013, d, pp. 60-60.

  C. Nativi; O. Francesconi; G. Gabrielli; I. De Simone; B. Turchetti; T. Mello; L. Di Cesare Mannelli; C. Ghelardini; P. Buzzini; S. Roelens (2012). Aminopyrrolic synthetic receptors for monosaccharides: A class of carbohydrate-binding agents endowed with antibiotic activity versus pathogenic yeasts. CHEMISTRY, vol. 18, pp. 5064-5072, ISSN:1521-3765 DOI   Accesso ONLINE all'editore

  L. Di Cesare Mannelli; L. Bonaccini; M. Zanardelli; T. Mello; A. Pacini; C. Ghelardini (2012). Involvement of alpha7 nAChR downregulation in rat oxaliplatin-induced neuropathy. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 117, pp. 57-57, ISSN:1122-6714

  L. Guandalini; E. Martini; L. Di Cesare Mannelli; S. Dei; D. Manetti; S. Scapecchi; E. Teodori; C. Ghelardini; M.N. Romanelli (2012). Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22, pp. 1936-1939, ISSN:0960-894X DOI   Accesso ONLINE all'editore

  V. Colotta; L. Squarcialupi; D. Catarzi; F. Varano; K. Varani; F. Vincenzi; M. Zanardelli; L. Di Cesare Mannelli; C. Ghelardini; S. Paoletta; S. Moro (2012). 2-Arylpyrazolo[4,3-d]pyrimidin-7-amino derivatives, new potent and selective human A3 adenosine receptor antagonists endowed with protective effect against oxaliplatin-induced apoptosis in rat astrocyte cell cultures. In: 21st National Meeting on Medicinal Chemistry, Palermo, 17-20 Luglio 2012, d, pp. 0-0.

  Luca Guandalini; Maria Vittoria Martino; Lorenzo Di Cesare Mannelli; Cristina Bellucci; Silvia Dei; Dina Manetti; Serena Scapecchi; Elisabetta Teodori; Carla Ghelardini; Maria Novella Romanelli (2012). New analogues of the potent nootropic drug DM235: 2-or 3-phenylpiperazines with limited conformational flexibility. In: 21 th National Meeting on Medicinal Chemistry, Palermo, 17-20 Luglio 2012, Società Chimica Italiana Divisione di Chimica Farmaceutica, pp. 74-74.

  Nistri S; Di Cesare Mannelli L; Mazzetti L; Feil R; Bani D; Failli P (2012). Restoring nitric oxide cytosolic calcium regulation by cyclic GMP protein kinase Ialpha transfection in coronary endothelial cells of spontaneously hypertensive rats. JOURNAL OF VASCULAR RESEARCH, vol. 49, pp. 221-230, ISSN:1018-1172 Accesso ONLINE all'editore

  Biava M; Battilocchio C; Poce G; Alfonso S; Porretta GC; Schenone S; Calderone V; Martelli A; Testai L; Ghelardini C; Di Cesare Mannelli L; Sautebin L; Rossi A; Giordani A; Patrignani P; Anzini M; Consalvi S (2012). Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, pp. 287-298, ISSN:0223-5234 DOI  

  A. Pacini; P.P. Duchini; L. Bonaccini; L. Di Cesare Mannelli; V. Selmi; C. adembri; L. Vitali; E. Sgambati (2012). Sepsis worsen the neurological outcome of traumatic brain injury: role of sialic acids related to glial activation. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 117, pp. 142-142, ISSN:1122-6714

  P. Failli; A. Vannacci; L. Di Cesare Mannelli; R. Motterlini; E. Masini (2012). RELAXANT EFFECT OF A WATER SOLUBLE CARBON MONOXIDE-RELEASING MOLECULE (CORM-3) ON SPONTANEOUSLY HYPERTENSIVE RAT AORTAS. CARDIOVASCULAR DRUGS AND THERAPY, vol. 26, pp. 285-292, ISSN:0920-3206 Accesso ONLINE all'editore

  L. Di Cesare Mannelli; M. Zanardelli; P. Failli; C. Ghelardini (2012). Oxaliplatin-induced neuropathy: oxidative stress as pathological mechanism. Protective effect of silibinin. THE JOURNAL OF PAIN, vol. 13, pp. 276-284, ISSN:1526-5900 Accesso ONLINE all'editore

  E. Martini; L. Di Cesare Mannelli; G. Bartolucci; C. Bertucci; S. Dei; C. Ghelardini; L. Guandalini; D. Manetti; S. Scapecchi; E. Teodori; M. N. Romanelli (2011). Synthesis and Biological Evaluation of 3,7-Diazabicyclo[4.3.0]2 nonan-8-ones as Potential Nootropic and Analgesic Drugs. JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, pp. 2512-2516, ISSN:0022-2623 DOI   Accesso ONLINE all'editore

  Lorenzo Di Cesare Mannelli;Elisa Vivoli;Alberto Salvicchi;Nicola Schiavone;Aleardo Koverech;Masa Messano;Raffaella Nicolai;Paola Benatti;Alessandro Bartolini;Carla Ghelardini (2011). Antidepressant-like effect of artemin in mice: a mechanism for acetyl-l-carnitine activity on depression. PSYCHOPHARMACOLOGY, vol. 218, pp. 347-356, ISSN:0033-3158 DOI  

  C. Ghelardini; L. Di Cesare Mannelli; M. Zanardelli; L. Bonaccini; A. Pacini (2011). Neuropathic pain: looking for a disease modifyng agent. In: XXI Convegno Nazionale del Gruppo Italiano per lo Studio della Neuromorfologia (GISN), San Benedetto del Tronto, 9-10 Giugno, pp. 0-0.

  L. Guandalini; E. Martini; L. Di Cesare Mannelli; S. Dei; D. Manetti; S. Scapecchi; E. Teodori; C. Ghelardini; M. Novella Romanelli (2011). Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs. In: XXIV Congresso Nazionale della Società Chimica Italiana, Lecce, 11-16 Settembre 2011, società chimica italiana, pp. 442-442.

  L. Di Cesare Mannelli; M. Zanardelli; A. pacini; C. Ghelardini (2011). Involvement of alpha7 nAChR downregulation in the rat oxaliplatin-induced neuropathy.. In: 35° Congresso Società Italiana di Farmacologia (SIF), Bologna, 14-17 Settembre, pp. 0-0.

  E.I. Nwankwo; F. Amenta; L. Di Cesare Mannelli; A. Pacini; L. Bonaccini; C. Ghelardini; S.K. Tayebati; D. Tomassoni (2011). Central nervous system changes in a model of compressive neuropathy: thioctic acid enantiomers activity.. In: XXI Convegno Nazionale del Gruppo perlo Studio della Neuromorfologia (GISN), San benedetto del Tronto, 9-10 Giugno, pp. 0-0.

  E.I. Nwankow; F. Amenta; L. Di Cesare Mannelli; A. Pacini; L. Bonaccini; C. Ghelardini; S.K. Tayebati; D. Tomassoni (2011). Thioctic acid enantiomers prevent central nervous system changes occurring in a model of compressive neuropathy. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 116, pp. 94-94, ISSN:1122-6714

  Biava M; Porretta GC; Poce G; Battilocchio C; Alfonso S; Rovini M; Valenti S; Giorgi G; Calderone V; Martelli A; Testai L; Sautebin L; Rossi A; Papa G; Ghelardini C; Di Cesare Mannelli L; Giordani A; Anzellotti P; Bruno A; Patrignani P; Anzini M (2011). Novel Analgesic/Anti-Inflammatory Agents: Diarylpyrrole Acetic Esters Endowed with Nitric Oxide Releasing Properties. JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, pp. 7759-7771, ISSN:1520-4804 DOI  

  L. Di Cesare Mannelli; L. Bonaccini; T. Mello; M. Zanardelli; A. Pacini; C. Ghelardini (2011). Oxaliplain-induced neruopathic pain: glial involvement in spinal cord and brain.. In: 34° Congresso Associazione Italiana per lo Studio del Dolore, Riccione, 29-31 Maggio, pp. 0-0.

  Anzini M; Valenti S; Braile C; Cappelli A; Vomero S; Alcaro S; Ortuso F; Marinelli L; Limongelli V; Novellino E; Betti L; Giannaccini G; Lucacchini A; Daniele S; Martini C; Ghelardini C; Di Cesare Mannelli L; Giorgi G; Mascia MP; Biggio G (2011). New insight into the central benzodiazepine receptor-ligand interactions: design, synthesis, biological evaluation, and molecular modeling of 3-substituted 6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and related compounds. JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, pp. 5694-5711, ISSN:1520-4804 DOI  

  Cappelli A; Bini G; Valenti S; Giuliani G; Paolino M; Anzini M; Vomero S; Giorgi G; Giordani A; Stasi LP; Makovec F; Ghelardini C; Di Cesare Mannelli L; Concas A; Porcu P; Biggio G (2011). Synthesis and structure-activity relationship studies in translocator protein ligands based on a pyrazolo[3,4-b]quinoline scaffold. JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, pp. 7165-7175, ISSN:1520-4804 DOI  

  L. Di Cesare Mannelli; C. dallanoce; C. Matera; M. Zanardelli; A. Pacini; C. De Micheli; M. De Amici; C. Ghelardini (2011). Chemotherapy-induced neuropathy: involvement of the alpha7 nAChR subtype.. In: New insights in the pharmacological control of pain, Milano, 30 settembre, pp. 0-0.

  L. Di Cesare Mannelli; L. Bonaccini; T. Mello; M. Zanardelli; A. Pacini; C. Ghelardini (2011). Glia activation along the nervous system during oxaliplatin-dependent neuropathic pain.. In: 8th IBRO World Congress of Neuroscience, Firenze, 14-18 Luglio, pp. 0-0.

  Bartolini, Alessandro; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla (2011). Analgesic and antineuropathic drugs acting through central cholinergic mechanisms. RECENT PATENTS ON CNS DRUG DISCOVERY, vol. 6, pp. 119-140, ISSN:2212-3954 DOI  

  A.R. Bilia; L. Di Cesare Mannelli; F. Firenzuoli; E. Gallo; C. Ghelardini; A. Karioti; A. Mugelli; A. Pacini; A. Vannacci; M. Zanardelli (2011). Estratti di Astragalus membranaceus loro preparazione ed uso come antiperalgesici ed antiallodinici. Numero: 1145PTIT A. MUGELLI

  G. Guerrini; G. Ciciani; F. Bruni; S. Selleri; C. Martini; S. Daniele; C. Ghelardini; L. Di Cesare Mannelli; A. Costanzo (2011). Development of ligands at gamma aminobutyrric acid type A (GABAA) receptor subtype as new agent for pain relief.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, pp. 7441-7452, ISSN:1464-3391 DOI  

  L. Bonaccini; L. Di Cesare Mannelli; M. Zanardelli; E. Sgambati; C. Ghelardini; A. Pacini (2011). An in vivo sudy on oxaliplatin-induced neuropathic pain: the protective effects of antioxidant compounds. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 116, pp. 26-26, ISSN:1122-6714

  C. Ghelardini; L. Di Cesare Mannelli; L. Bonaccini; A. Pacini; A. Bartolini (2010). Oxaliplatin-induced neuropathy: glial activation in spinal cord and brain.. In: 16th World Congress of Basic and Clinical Pharmacology, Copenaghen - Danimarca, 17-23 Luglio, pp. 0-0.

  Vivoli E; Di Cesare Mannelli L; Salvicchi A; Bartolini A; Koverech A; nicolai R; Benatti P; Ghelardini C (2010). Acetyl-L-carnitine increases artemin level and prevents neurotrophic factor alterations during neuropathy. NEUROSCIENCE, vol. 167, pp. 1168-1174, ISSN:0306-4522 DOI  

  L. Di Cesare Mannelli; L. Bonaccini; A. Pacini; C. Ghelardini; A. Bartolini (2010). Oxaliplatin-dependent neuropathy in the rat: pain behaviour and peripheral nervous system alterations.. In: 16th World Congress of Basic and Clinical Pharmacology, Copenhagen - Danimarca, 17-23 Luglio, pp. 0-0.

  D. Tomassoni; L. Di Cesare Mannelli; A. Pacini; L. Bonaccini; C. Ghelardini; E. Traini; F. Amenta (2010). Morpho-functional evaluation of the activity of stereoisomers of the antioxidant alpha-lipoic (tioctic) acid in a model of compressive neuropathy. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 115, pp. 166-166, ISSN:1122-6714

  A.Pacini; L.Di Cesare Mannelli; L.Bonaccini; S.Ronzoni; A.Bartolini; C.Ghelardini (2010). Protective effect of alpha7 nAChR: behavioural and morphological features on neuropathy. PAIN, vol. 150, pp. 542-549, ISSN:0304-3959 DOI  

  L. Bonaccini; T. Mello; C. Ghelardini; E. Sgambati; L. Di Cesare Mannelli; A. Pacini (2010). Oxaliplatin-induced neuropathy: glial activation in spinal cord and brain. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 115, pp. 23-23, ISSN:1122-6714

  D. Tomassoni; L. Di Cesare Mannelli; L. Bonaccini; A. Pacini; D. Alagna; C. Ghelardini; F. Amenta (2010). Valutazione comparativa dell'efficacia dell'acido tioctico enantiomero (+) e racemo (+/-) in modelli di aumentato stress ossidativo.. In: R (+) dalla ricerca di base alle applicazioni cliniche dell'enantiomero naturale di un antiossidante multifunzionale, Roma, 14 Settembre, pp. 0-0.

  L. Di Cesare Mannelli; L. Bonaccini; A. Pacini; C. Ghelardini (2010). Alteration in neuron and glia gene expression profile as actors involved in the bmechanism of oxaliplatin-dependen neuropathy.. In: 3rd International Congress on Neuropathic Pain (NeuPSIG), Atene - Grecia, 27-30 Maggio, pp. 0-0.

  Di Cesare Mannelli L.; Ghelardini C.; Toscano A.; Pacini A.; Bartolini A. (2010). The neuropathy-protective agent acetyl-L-carnitine actives PKC-gamma and MAPKs in a rat model of neuropathic pain.. NEUROSCIENCE, vol. 165, pp. 1345-1352, ISSN:0306-4522 DOI  

  A. Pacini; L. Di Cesare Mannelli; L. Bonaccini; A. Toscano; C. Ghelardini; P. Pacini (2009). Glial activation and nervous tissue alteration: oxaliplatin-induced neuropathy. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 114, pp. 168-168, ISSN:1122-6714

  L. Di Cesare Mannelli; A. Pacini; C. carovani; C. Ghelardini; A. Bartolini (2009). Oxaliplatin-induced neuropathic pain: glial activation and characteristic nervous tiossue alteration.. In: 34° Congresso della Società Italiana di Farmacologia, Rimini, 14-17 Ottobre, pp. 0-0.

  L. Bonaccini; L. Di Cesare Mannelli; C. Ghelardini; A. Pacini (2009). Morphological and functional modifications of the nervous system in a rat model of oxaliplatin-dependent neuropathy.. In: National Symposium on peripheral nerve repair and regeneration, Torino, 4-5 Dicembre, pp. 0-0.

  Dina Manetti; Lorenzo Di Cesare Mannelli; Silvia Dei; Luca Guandalini; Elisabetta Martini; Martina Banchelli; Carla Ghelardini (2009). [35S]GTPgammaS binding studies of amphiphilic drugs-activated Gi proteins: A caveat. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, pp. 2224-2229, ISSN:0960-894X DOI  

  L. Di Cesare Mannelli; C. Ghelardini; M. Calvani; R. Nicolai; L. Mosconi; A. Toscano; A. Pacini; A. Bartolini (2009). Neuroprotective effects of acetyl-L-carnitine on neuropathic pain and apoptosis: A role for the nicotinic receptor. JOURNAL OF NEUROSCIENCE RESEARCH, vol. 87, pp. 200-207, ISSN:0360-4012 DOI  

  F. Amenta; D. Tomassoni; L. Di Cesare Mannelli; A. Pacini; K. Tayebaty; E. Traini; C. Ghelardini (2009). Tioctic acid as a possible neuroprotective agent in an animal model of neuropathy. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 114, pp. 17-17, ISSN:1122-6714

  Di Cesare Mannelli, Lorenzo; Bartolini, A.; Ghelardini, C. (2009). Neuropathy-induced apoptosis: Protective effect of physostigmine. JOURNAL OF NEUROSCIENCE RESEARCH, vol. 87, pp. 1871-1876, ISSN:0360-4012 DOI   Accesso ONLINE all'editore

  L. DI CESARE MANNELLI ; S. NISTRI; L. MAZZETTI; D. BANI; R. FEIL; P. FAILLI (2009). Altered nitric oxide calcium responsiveness of aortic smooth muscle cells in spontaneously hypertensive rats depends on low expression of cyclic guanosine monophosphate-dependent protein kinase type I. JOURNAL OF HYPERTENSION, vol. 27, pp. 1258-1267, ISSN:0263-6352 DOI   Accesso ONLINE all'editore

  P. Luciani; D. Berti; M. Fortini; P. Baglioni; C. Ghelardini; A. Pacini; D. Manetti; F. Gualtieri; A. Bartolini; L. Di Cesare Mannelli (2009). Receptor-independent modulation of reconstituted Galphai protein mediated by liposomes. MOLECULAR BIOSYSTEMS, vol. 5, pp. 356-367, ISSN:1742-206X DOI  

  Failli P; Bani D; Cantore M; Di Cesare Mannelli L; Ghelardini C; Giorgi C; Innocenti M; Udisti R; Rugi F; Spepi A;Valtancoli B; Bencini A. (2009). A novel manganese complex effective as superoxide anion scavenger and therapeutic agent against cell and tissue oxidative injury.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, pp. 7273-7283, ISSN:0022-2623 DOI   Accesso ONLINE all'editore

  D. Tomassoni; L. Di Cesare Mannelli; A. Pacini; A. Toscano; C. Ghelardini; F. Amenta (2008). Morphological changes of sciatic nerve following loose ligation: protective effects of acetyl-L-carnitine. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 113, pp. 273-273, ISSN:1122-6714

  A. Pacini; A. Toscano; L. Bonaccini; P. Pacini; Ghelardini C.; L. Di Cesare Mannelli (2008). Protective effect of alpha7 NACHR: morphological features on neuropathy.. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 113, pp. 216-216, ISSN:1122-6714

  L. Di Cesare Mannelli; A. Pacini; L. Bonaccini; M. Bercigli; A. Toscano; A. Bartolini; C. Ghelardini; (2008). Alpha7 nAChR agonists: anti-hyperalgesic and neuroprotective role on neuropathy.. In: XVIII Convegno Nazionale del Gruppo Italiano per lo Studio della Neuromorfologia (GISN), Bologna, 21-22 Novembre, pp. 0-0.

  D. Tomassoni; L. Di Cesare Mannelli; A. Pacini; A. Toscano; E. Baldoni; C. Ghelardini; F. Amenta (2008). Protective effects of acetyl-L-carnitine in sciatic nerve following loose ligation: a functional and morphological study.. In: XVIII Convegno Nazionale del Gruppo Italiano per lo Studio della Neuromorfologia (GISN), Bologna, 21-22 Novembre, pp. 0-0.

  L. Di Cesare Mannelli; C. Ghelardini; M. Calvani; R. Nicolai; L. Mosconi; E. Vivoli; A. Pacini; A. Bartolini (2007). Protective effect of Acetyl-L-Carnitine on the apoptotic pathway of peripheral neuropathy. EUROPEAN JOURNAL OF NEUROSCIENCE, vol. 26, pp. 820-827, ISSN:0953-816X DOI  

  L. Di Cesare Mannelli; A. Pacini; A. Toscano; C. Ghelardini; A. Bartolini (2007). Neuroprotective effects of acetyl-L-carnitine on neuropathic pain and apoptosis: nicotinic receptor role.. In: XVII Convegno Nazionale del Gruppo Italiano per lo Studio della Neuromorfologia (GISN), Catania, 16-17 Novembre, pp. 0-0.

  L. Di Cesare Mannelli; A. Pacini; A. Toscano; C. Ghelardini; A. Bartolini (2006). Antiapoptotic effect of physostigmine in a peripheral neuropathy model.. In: XVI Convegno Nazionale del Gruppo Italiano per lo Studio della Neuromorfologia (GISN), Bologna, 23-24 Novembre, pp. 0-0.

  Di Cesare Mannelli, L.; Pacini, A.; Toscano, A.; Fortini, M.; Berti, D.; Ghelardini, C.; Galeotti, N.; Baglioni, P.; Bartolini, A. (2006). Gi/o proteins: expression for direct activation enquiry. PROTEIN EXPRESSION AND PURIFICATION, vol. 47, pp. 303-310, ISSN:1046-5928, Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445 ACADEMIC PRESS INC ELSEVIER SCIENCE, 525 B ST, STE 1900, SAN DIEGO, USA, CA, 92101-4495: DOI  

  L. DI CESARE MANNELLI; A. PACINI; A. TOSCANO; C. GHELARDINI; D. MANETTI; F. GUALTIERI; T. PATEL; A. BARTOLINI (2006). A recombinant transductor-effector system: in vitro study of G inhibitor protein (G-alfa-i1)direct activators. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 453, pp. 151-160, ISSN:0003-9861 DOI  

  D. Manetti; L. Di Cesare Mannelli; S. Dei; N. Galeotti; C. Ghelardini; M. Romanelli; S. Scapecchi; E. Teodori; A. Pacini; A. Bartolini; F. Gualtieri (2005). Design, synthesis and preliminary pharmacological evaluation of a set of small molecules that directly activate Gi proteins.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, pp. 6491-6503, ISSN:0022-2623 DOI  

  A. Pacini; A. Toscano; V. Cesati; A. Cozzi; E. Meli; L. Di Cesare Mannelli; F. Paternostro ; P. Pacini; D.E. Pellegrini Giampietro (2005). NAPOR-3 RNA binding protein is required for apoptosis in hippocampus. MOLECULAR BRAIN RESEARCH, vol. 140, pp. 34-44, ISSN:0169-328X DOI  

  L. Di Cesare Mannelli; A. Pacini; A. Toscano; D. Manetti; F. Gualtieri; A. Bartolini (2005). Piperazine derivatives as direct activator of Gi/o proteins.. In: 32° Congresso della Società Italiana di farmacologia (SIF), Napoli, 1-4 Giugno 2005, Società Italiana di farmacologia (SIF), pp. 6-6.

  A. Toscano; L. Di Cesare Mannelli; C. Ghelardini; N. galeotti; A. bartolini; A. Pacini (2005). Transductor-effector system as model for the study of Gi protein dysfunction treatment.. In: XV Convegno Nazionale del Gruppo Italiano per lo Studio della Neuromorfologia (GISN), Bologna, 24-25 Novembre, Gruppo Italiano per lo Studio della Neuromorfologia (GISN), pp. 0-0.

  D. Manetti; L.Di Cesare Mannelli; S. Dei; N. Galeotti; C. Ghelardini; M.N. Romanelli; S. Scapecchi; E. Teodori; A. Bartolini; F. Gualtieri (2004). Progettazione, sintesi e valutazione farmacologica preliminare di attivatori diretti delle proteine Gi. In: XVII Convegno Nazionale della Divisione di Chimica Farmaceutica della Società Chimica Italiana, Pisa, 6-10 Settembre 2004, Società Chimica Italiana, pp. 249-249.

  L. Di Cesare Mannelli; A. Pacini; A. Bartolini (2003). Gi proteins: a recombinant DNA approach.. In: 31° Congresso Nazionale della Società Italiana di Farmacologia (SIF), Trieste, 26-29 Giugno, pp. 0-0.

  A. Pacini ; V. Cesati ;C. Sassoli ;A. Bartolini ;P. Pacini;L. Di Cesare Mannelli (2003). Gi proteins activators: new therapeutic perspectives?. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, pp. 151-151, ISSN:1122-6714

  L. Di Cesare Mannelli; C. Sassoli; V. Cesati; A. Pacini (2003). Gi proteins signalling pathway: receptor-independent mechanisms.. In: XIII Convegno Nazionale del Gruppo Italiano per lo Studio della Neuromorfologia (GISN), Bologna, 5-6 Dicembre, pp. 0-0.

  N. GALEOTTI; L. DI CESARE MANNELLI; G. MAZZANTINI; A. BARTOLINI; C. GHELARDINI (2002). MENTHOL: A NATURAL ANALGESIC COMPOUND. NEUROSCIENCE LETTERS, vol. 322, pp. 145-148, ISSN:0304-3940 DOI   Accesso ONLINE all'editore

  C. Ghelardini;N. Galeotti;L. Di Cesare Mannelli;G. Mazzanti;A. Bartolini (2001). Local anaesthetic activity of beta-caryophyllene.. IL FARMACO, vol. 56, pp. 387-389, ISSN:0014-827X DOI  

  C. GHELARDINI; N. GALEOTTI; L. DI CESARE MANNELLI; A. CAPPELLI; M. ANZINI; A. BARTOLINI (2001). ANTIAMNESIC EFFECT OF THE TWO NOVEL K-OPIOID AGONISTS, VA-100 AND VA-101, IN THE MOUSE PASSIVE AVOIDANCE TEST. DRUG DEVELOPMENT RESEARCH, vol. 54, pp. 12-18, ISSN:0272-4391 DOI  

  N. GALEOTTI; C. GHELARDINI; L. DI CESARE MANNELLI; G. MAZZANTI; L. BAGHIROLI; A. BARTOLINI (2001). LOCAL ANAESTHETIC ACTIVITY OF (+) AND (-) MENTHOL. PLANTA MEDICA, vol. 67, pp. 174-176, ISSN:0032-0943 DOI   Accesso ONLINE all'editore

  N. GALEOTTI; C. GHELARDINI; L. DI CESARE MANNELLI; A. BARTOLINI (2001). ANTINOCICEPTIVE PROFILE OF THE NATURAL CHOLINESTERASE INHIBITOR HUPERZINE A. DRUG DEVELOPMENT RESEARCH, vol. 54, pp. 19-26, ISSN:0272-4391 DOI   Accesso ONLINE all'editore

  C Ghelardini; N Galeotti; L Di Cesare Mannelli; M Nicolodi; F Sicuteri; C Uslenghi; I Grazioli; A Bartolini (2000). Effetto antiiperalgico della proclorperazina. In: V. Gallai, G. Mazzotta, P. Sarchielli, A. Alberti. Nuove prospettive nella terapia delle Cefalee, pp. 379-381, Firenze: V. Gallai, G. Mazzotta, P. Sarchielli, A. Alberti.

  A Bartolini; L Di Cesare Mannelli; N Galeotti; C Lelli; S Livi; C Uslenghi; I Grazioli; C Ghelardini (2000). Un’aumentata liberazione di acetilcolina alla base dell’effetto analgesico indotto da proclorperazina. In: V. Gallai, G. Mazzotta, P. Sarchielli, A. Alberti. : Nuove prospettive nella terapia delle Cefalee, pp. 357-359, Firenze: V. Gallai, G. Mazzotta, P. Sarchielli, A. Alberti.

  C. GHELARDINI; N. GALEOTTI; L. DI CESARE MANNELLI; S. DEI; F. GUALTIERI; A. BARTOLINI (2000). AG-4:A NICOTINIC AGONIST ENDOWED WITH ANTIAMNESIC PROPERTIES. DRUG DEVELOPMENT RESEARCH, vol. 51, pp. 191-196, ISSN:0272-4391 DOI