Maria Paola GIOVANNONI

Ruolo attuale:: Professore Associato
SSD:: CHEM-07/A - Chimica farmaceutica
Afferenza organizzativa:: Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino (NEUROFARBA)

Recapiti

	0554573682
	mariapaola.giovannoni(AT)unifi.it

Avvisi

INIZIO corso ANALISI DEI FARMACI III

Il corso di ANALISI DEI FARMACI III a FREQUENZA OBBLIGATORIA inizierà lunedì 21 settembre alle ore 11.15, aula 103 del plesso didattico di Viale Morgagni. E' obbligatorio scriversi su MOODLE e su SOL per accedere al laboratorio.

INIZIO corso CHIMICA FARMACEUTICA E TOSSICOLOGICA I

Il corso di CHIMICA FARMACEUTICA E TOSSICOLOGICA I, a frequenza obbligatoria, inizierà il giorno MARTEDI' 22 SETTEMBRE alle ore 8.30 nell'aula 01 della tendostruttura Franklin, via del Guado SESTO FIORENTINO. Gli studenti devono iscriversi su MOODLE

Maria Paola GIOVANNONI

Orario di ricevimento (aggiornato al 03/06/2013) Tutti i giorni previo appuntamento telefonico o per e-mail.

Maria Paola GIOVANNONI

Biografia

Laurea in Chimica e Tecnologia Farmaceutiche presso l'Università degli Studi di Firenze, con votazione 110/110 e lode
Laurea in Farmacia presso l'Università degli Studi di Firenze, con votazione 110/110 e lode (1991)
Titolo di Dottore di Ricerca in Chimica del Farmaco, presso l'Università di Firenze (1995)
Ricercatore (SSD CHIM/08), presso l'Università di Firenze (1996-2015)
Professore associato (SSD CHIM/08 ora CHEM-07/A), presso l'Università di Firenze (dal 2015)

Maria Paola GIOVANNONI

Curriculum

Formazione e progressione di carriera

Laurea in Chimica e Tecnologia Farmaceutiche presso l'Università degli Studi di Firenze, con votazione 110/110 e lode
Laurea in Farmacia presso l'Università degli Studi di Firenze, con votazione 110/110 e lode (1991)
Titolo di Dottore di Ricerca in Chimica del Farmaco, presso l'Università di Firenze (1995).
Ricercatore (SSD CHIM/08), presso l'Università di Firenze (1996-2015).
Professore associato (SSD CHIM/08 ora CHEM-07/A), presso l'Università di Firenze (dal 2015).

Principali attività

Titolare dei fondi ministeriali ex 60% (dal 2010)
Responsabile di convenzioni stipulate con l’industria (2010-2015 CHIESI SpA)
PI finanziamento da Ente Cassa di Risparmio (2015)
Tutor universitario per stage in riferimento alla convenzione stipulata tra l’Università di Firenze e le aziende ELI LILLY ITALIA SpA e GSK Vaccines SRL (dal 2015 ad oggi)
Tutor scientifico di tesi di Dottorato (dal 2014 ad oggi)
Membro effettivo della Commissione per gli Esami di Stato per l’abilitazione alla professione di Farmacista (2017-2019)
Referente PCTO Scuola Scienze Salute Umana (SSSU) – Area Farmaco (dal 2019 ad oggi)

Attività didattica

L’attività didattica è stata svolta presso l’Università di Firenze, nei vari Corsi di Laurea della ex Facoltà di Farmacia e attuale Scuola di Scienze della Salute Umana

Corso di Studio in Chimica e Tecnologia Farmaceutiche

Assistenza di laboratorio e codocenza sul corso Analisi dei Medicinali (1996-2009)
Titolare del corso Analisi dei farmaci II (attualmente Analisi dei farmaci III) (dal 2009 ad oggi)

Corso di Studio in Farmacia

Titolare di un modulo di 2 CFU per il corso di Chimica Farmaceutica I (attualmente Chimica Farmaceutica e Tossicologica I) (dal 2000 ad oggi)

Corso di Studio in Tecniche Erboristiche

Titolare del corso Analisi II (2005-2009)

Corso di Studio in Scienze Farmaceutiche Applicate

Titolare del corso Analisi dei Prodotti Erboristici II (2009-2011)

Attività di ricerca

E’ autore di più di 110 pubblicazioni su riviste internazionali.

L’attività di ricerca riguarda principalmente la progettazione, la sintesi e lo studio di composti che agiscono su macromolecole biologiche quali enzimi, recettori e proteine canale. I principali campi di investigazione sono:

Inibitori dell’Elastasi dei Neutrofili Umani (HNE)
Ligandi dei Recettori dei Peptidi Formilati (FPRs)
Antagonisti dei recettori dell’adenosina (A₁/A₃)
Inibitori delle Fosfodiesterasi IV (PDEIV)
Bloccanti del canale Pannexina 1 (Panx1)

Maria Paola GIOVANNONI

Interessi

Attività di ricerca

Autore di più di 110 pubblicazioni su riviste internazionali.

L’attività di ricerca riguarda principalmente la progettazione, la sintesi e lo studio di composti che agiscono su macromolecole biologiche quali enzimi, recettori e proteine canale. I principali campi di investigazione sono:

Inibitori dell’Elastasi dei Neutrofili Umani (HNE)
Ligandi dei Recettori dei Peptidi Formilati (FPRs)
Antagonisti dei recettori dell’adenosina (A₁/A₃)
Inibitori delle Fosfodiesterasi IV (PDEIV)
Bloccanti del canale Pannexina 1 (Panx1)

Maria Paola GIOVANNONI

Pubblicazioni

Legenda

Contributo su rivista |

Articolo su libro |

Libro |

Contributo in atti di convegno (proceeding) |

Brevetto |

Curatela | Altro

Altro |

Tesi di Dottorato

Guerrini, Gabriella; Giovannoni, Maria Paola (2026). Special Issue “Ion Channels as a Therapeutic Target: Drug Design and Pharmacological Investigation 2.0. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 27, pp. 1-5, ISSN:1422-0067 DOI

Vergelli, Claudia; Crocetti, Letizia; Guerrini, Gabriella; Melani, Fabrizio; Gracia, Jordi; Buil, Maria Antonia; Garrido, Yolanda; Pagès, Lluis; Taltavull, Joan; Gavaldà, Amadeu; Calama, Elena; Giovannoni, Maria Paola (2026). Discovery of Potent PDE4 Inhibitors with 3(2H)-Pyridazinone Scaffold: Synthesis, In Silico Studies and In Vitro/Vivo Evaluation. MOLECULES, vol. 31, pp. 1-36, ISSN:1420-3049 DOI

Vergelli, Claudia; Cilibrizzi, Agostino; Guerrini, Gabriella; Melani, Fabrizio; Menicatti, Marta; Bartolucci, Gian Luca; Giovannoni, Maria Paola; Crocetti, Letizia (2025). Polynitrogen Bicyclic and Tricyclic Compounds as PDE4 Inhibitors. APPLIED SCIENCES, vol. 15, pp. 1-32, ISSN:2076-3417 DOI

Letizia Crocetti, Maria Paola Giovannoni, Tengis S. Pavlov, Veniamin Ivanov, Fabrizio Melani, Gabriella Guerrini (2025). Synthesis of 3-Carboxy-6-sulfamoylquinolones and Mefloquine-Based Compounds as Panx1 Blockers: Molecular Docking, Electrophysiological and Cell Culture Studies. MOLECULES, vol. 30, pp. 2171-2195, ISSN:1420-3049 DOI Accesso ONLINE all'editore

Crocetti, Letizia; Pearce, Abigail; Vege, Venkat S.; Xu, Qi; Xu, Jing; Buthmann, Hannes; Giovannoni, Maria Paola; Guerrini, Gabriella; Catarzi, Francesca; Selleri, Silvia; Huang, Xianglin; Chandran, Aneesh; Ladds, Graham; Cilibrizzi, Agostino (2025). New heterocyclic A1/A3 adenosine receptor ligands through molecular simplification strategies. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY REPORTS, vol. 13, pp. 0-0, ISSN:2772-4174 DOI

Crocetti, Letizia; Catarzi, Francesca; Giovannoni, Maria Paola; Vergelli, Claudia; Bartolucci, Gianluca; Pallecchi, Marco; Paoli, Paola; Rossi, Patrizia; Lippi, Martina; Schepetkin, Igor A.; Quinn, Mark T.; Guerrini, Gabriella (2024). Ebselen analogues with dual human neutrophil elastase (HNE) inhibitory and antiradical activity. RSC MEDICINAL CHEMISTRY, pp. 1-11, ISSN:2632-8682 DOI

Crocetti, Letizia; Khlebnikov, Andrei I.; Guerrini, Gabriella; Schepetkin, Igor A.; Melani, Fabrizio; Giovannoni, Maria Paola; Quinn, Mark T. (2024). Anti-Inflammatory Activity of Pyrazolo[1,5-a]quinazolines. MOLECULES, vol. 29, pp. 1-24, ISSN:1420-3049 DOI

Crocetti, Letizia; Guerrini, Gabriella; Melani, Fabrizio; Mascia, Maria Paola; Giovannoni, Maria Paola (2024). 3,8-Disubstituted Pyrazolo[1,5-a]quinazoline as GABAA Receptor Modulators: Synthesis, Electrophysiological Assays, and Molecular Modelling Studies. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 25, pp. 1-23, ISSN:1422-0067 DOI

Guerrini, Gabriella; Giovannoni, Maria Paola (2024). Ion Channels as a Therapeutic Target: Drug Design and Pharmacological Investigation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 25, pp. 1-4, ISSN:1422-0067 DOI

Crocetti, Letizia; Giovannoni, Maria Paola; Vergelli, Claudia; Guerrini, Gabriella; Melani, Fabrizio; Cilibrizzi, Agostino (2024). New quinoline-based PDE4 inhibitors through GSK-256066 fragment-based elaboration. JOURNAL OF MOLECULAR STRUCTURE, vol. 1295, pp. 136719-136734, ISSN:0022-2860 DOI Accesso ONLINE all'editore

Crocetti, Letizia; Guerrini, Gabriella; Melani, Fabrizio; Vergelli, Claudia; Giovannoni, Maria Paola (2023). 4,5-Dihydro-5-Oxo-Pyrazolo[1,5-a]Thieno[2,3-c]Pyrimidine: A Novel Scaffold Containing Thiophene Ring. Chemical Reactivity and In Silico Studies to Predict the Profile to GABAA Receptor Subtype. MOLECULES, vol. 28, pp. 3054-3074, ISSN:1420-3049 DOI

Jin, Jian; Mazzacuva, Francesca; Crocetti, Letizia; Giovannoni, Maria Paola; Cilibrizzi, Agostino (2023). PDE4 Inhibitors: Profiling Hits through the Multitude of Structural Classes. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 24, pp. 11518-11538, ISSN:1422-0067 DOI

Ferrara V.; Toti A.; Lucarini E.; Parisio C.; Micheli L.; Ciampi C.; Margiotta F.; Crocetti L.; Vergelli C.; Giovannoni M.P.; Di Cesare Mannelli L.; Ghelardini C. (2023). Protective and Pain-Killer Effects of AMC3, a Novel N-Formyl Peptide Receptors (FPRs) Modulator, in Experimental Models of Rheumatoid Arthritis. ANTIOXIDANTS, vol. 12, pp. 1207-1226, ISSN:2076-3921 DOI

Crocetti, Letizia; Giovannoni, Maria Paola; Guerrini, Gabriella; Lamanna, Silvia; Melani, Fabrizio; Bartolucci, Gian Luca; Pallecchi, Marco; Paoli, Paola; Lippi, Martina; Wang, Junjie; Dahl, Gerhard (2023). Design, Synthesis and Pharmacological Evaluation of New Quinoline-Based Panx-1 Channel Blockers. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 24, pp. 1-23, ISSN:1422-0067 DOI Accesso ONLINE all'editore

Gerace A.; Masini V.; Crocetti L.; Giovannoni M.P.; Ferraroni M. (2023). X-ray structural study of human neutrophil elastase inhibition with a series of azaindoles, azaindazoles and isoxazolones. JOURNAL OF MOLECULAR STRUCTURE, vol. 1274, pp. 134595-134601, ISSN:0022-2860 DOI

Crocetti, Letizia; Floresta, Giuseppe; Zagni, Chiara; Merugu, Divya; Mazzacuva, Francesca; de Oliveira Silva, Renan Rodrigues; Vergelli, Claudia; Giovannoni, Maria Paola; Cilibrizzi, Agostino (2022). Ligand Growing Experiments Suggested 4-amino and 4-ureido pyridazin-3(2H)-one as Novel Scaffold for FABP4 Inhibition. PHARMACEUTICALS, vol. 15, pp. 1335-1365, ISSN:1424-8247 DOI

Crocetti, Letizia; Guerrini, Gabriella; Giovannoni, Maria Paola; Melani, Fabrizio; Lamanna, Silvia; Di Cesare Mannelli, Lorenzo; Lucarini, Elena; Ghelardini, Carla; Wang, Junjie; Dahl, Gerhard (2022). New Panx-1 Blockers: Synthesis, Biological Evaluation and Molecular Dynamic Studies. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, pp. 4827-4855, ISSN:1422-0067 DOI

Crocetti, Letizia; Quinn, Mark T; Cilibrizzi, Agostino; Giovannoni, Maria Paola (2022). Editorial: Serine protease inhibitors and their therapeutic applications. FRONTIERS IN CHEMISTRY, vol. 10, pp. 980152-980155, ISSN:2296-2646 DOI

Crocetti, Letizia; Floresta, Giuseppe; Cilibrizzi, Agostino; Giovannoni, Maria Paola (2022). An Overview of PDE4 Inhibitors in Clinical Trials: 2010 to Early 2022. MOLECULES, vol. 27, pp. 4964-4989, ISSN:1420-3049 DOI

Letizia Crocetti, Gabriella Guerrini, Fabrizio Melani, Claudia Vergelli, Maria Paola Giovannoni, Maria Paola Mascia (2022). GABAA receptor modulators with a pyrazolo[1,5-a]quinazoline core: synthesis, molecular modelling studies and electrophysiological assay. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, pp. 13032-13051, ISSN:1422-0067 DOI

Claudia Vergelli, Letizia Crocetti, Maria Paola Giovannoni, Giuseppe Floresta, Shabnam Nazir, Amrit Bhogal, Claudio Biancalani, Nicoletta Cesari, Agostino Cilibrizzi (2022). Synthesis and inverse virtual screening of new bi-cyclic structures towards cancer-relevant cellular targets. STRUCTURAL CHEMISTRY, pp. 0-0, ISSN:1040-0400 DOI

Letizia Crocetti, Gabriella Guerrini, Claudia Vergelli, Maria Paola Giovannoni, Gian Luca Bartolucci, Silvia Lamanna, Marco Pallecchi, Paola Paoli, Patrizia Rossi (2022). Molecular manipulation of the 1,5,6,7-tetrahydro-4 H -indazol-4-one scaffold to obtain new human neutrophil elastase (HNE) inhibitors. JOURNAL OF MOLECULAR STRUCTURE, vol. 1263, pp. 133140-133154, ISSN:0022-2860 DOI Accesso ONLINE all'editore

Cantini N.; Schepetkin I.A.; Danilenko N.V.; Khlebnikov A.I.; Crocetti L.; Giovannoni M.P.; Kirpotina L.N.; Quinn M.T. (2022). Pyridazinones and Structurally Related Derivatives with Anti-Inflammatory Activity. MOLECULES, vol. 27, pp. 3749-3776, ISSN:1420-3049 DOI

Rossi P.; Ceccarelli J.; Milazzo S.; Paoli P.; Morais Missina J.; Ciattini S.; Ienco A.; Tuci G.; Valleri M.; Giovannoni M.P.; Guerrini G.; Conti L. (2021). Nonsteroidal Anti-Inflammatory Drugs-1-Phenylethylamine Diastereomeric Salts: A Systematic Solid-State Investigation. CRYSTAL GROWTH & DESIGN, vol. 21, pp. 6947-6960, ISSN:1528-7483 DOI Accesso ONLINE all'editore

Vergelli C.; Khlebnikov A.I.; Crocetti L.; Guerrini G.; Cantini N.; Kirpotina L.N.; Schepetkin I.A.; Cilibrizzi A.; Quinn M.T.; Rossi P.; Paoli P.; Giovannoni M.P. (2021). Synthesis, biological evaluation, molecular modeling, and structural analysis of new pyrazole and pyrazolone derivatives as N-formyl peptide receptors agonists. CHEMICAL BIOLOGY & DRUG DESIGN, vol. 98, pp. 582-603, ISSN:1747-0277 DOI

Crocetti, Letizia; Guerrini, Gabriella; Cantini, Niccolò; Vergelli, Claudia; Melani, Fabrizio; Mascia, Maria Paola; Giovannoni, Maria Paola (2021). 'Proximity frequencies' a new parameter to evaluate the profile of GABAAR modulators. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 34, pp. 127755-127762, ISSN:0960-894X DOI

Cantini, Niccolò; Khlebnikov, Andrei I.; Crocetti, Letizia; Schepetkin, Igor A.; Floresta, Giuseppe; Guerrini, Gabriella; Vergelli, Claudia; Bartolucci, Gianluca; Quinn, Mark T.; Paola Giovannoni, Maria (2021). Exploration of Nitrogen Heterocycle Scaffolds for the Development of Potent Human Neutrophil Elastase Inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 29, pp. 1-17, ISSN:0968-0896 DOI

Crocetti, Letizia; Vergelli, Claudia; Guerrini, Gabriella; Giovannoni, Maria Paola; Kirpotina, Liliya N.; Khlebnikov, Andrei I.; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo; Lucarini, Elena; Schepetkin, Igor A.; Quinn, Mark T. (2021). Pyridinone Derivatives as Interesting Formyl Peptide Receptor (FPR) Agonists for the Treatment of Rheumatoid Arthritis. MOLECULES, vol. 26, pp. 6583-6583, ISSN:1420-3049 DOI Accesso ONLINE all'editore

Cantini, Niccolo; Crocetti, Letizia; Guerrini, Gabriella; Vergelli, Claudia; Schepetkin, Igor A; Pallecchi, Marco; Bartolucci, Gian Luca; Quinn, Mark T; Teodori, Elisabetta; Paola Giovannoni, Maria (2021). 1,5,6,7-Tetrahydro-4H-indazol-4-ones as human neutrophil elastase (HNE) inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 52, pp. 128380-128386, ISSN:0960-894X DOI

Crocetti, Letizia; Guerrini, Gabriella; Puglioli, Sara; Giovannoni, Maria Paola; Di Cesare Mannelli, Lorenzo; Lucarini, Elena; Ghelardini, Carla; Wang, Junjie; Dahl, Gerhard (2021). Design and synthesis of the first indole-based blockers of Panx-1 channel. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 223, pp. 113650-113660, ISSN:0223-5234 DOI

Crocetti L.; Giovannoni M.P.; Cantini N.; Guerrini G.; Vergelli C.; Schepetkin I.A.; Khlebnikov A.I.; Quinn M.T. (2020). Novel Sulfonamide Analogs of Sivelestat as Potent Human Neutrophil Elastase Inhibitors. FRONTIERS IN CHEMISTRY, vol. 8, pp. 795-811, ISSN:2296-2646 DOI

Μaione, Francesco; Colucci, Mariantonella; Raucci, Federica; Mangano, Giorgina; Marzoli, Francesca; Mascolo, Nicola; Crocetti, Letizia; Giovannoni, Maria Paola; Di Giannuario, Amalia; Pieretti, Stefano (2020). New insights on the arylpiperazinylalkyl pyridazinone ET1 as potent antinociceptive and anti-inflammatory agent. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 888, pp. 173572-173585, ISSN:0014-2999 DOI

Floresta G.; Crocetti L.; Giovannoni M.P.; Biagini P.; Cilibrizzi A. (2020). Repurposing strategies on pyridazinone-based series by pharmacophore- and structure-driven screening. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 1137-1144, ISSN:1475-6366 DOI

Crocetti L.; Vergelli C.; Guerrini G.; Cantini N.; Kirpotina L.N.; Schepetkin I.A.; Quinn M.T.; Parisio C.; Di Cesare Mannelli L.; Ghelardini C.; Giovannoni M.P. (2020). Novel formyl peptide receptor (FPR) agonists with pyridinone and pyrimidindione scaffolds that are potentially useful for the treatment of rheumatoid arthritis. BIOORGANIC CHEMISTRY, vol. 100, pp. 1-12, ISSN:0045-2068 DOI

Maria Paola Giovannoni, Letizia Crocetti, Niccolò Cantini, Gabriella Guerrini, Claudia Vergelli, Antonella Iacovone, Elisabetta Teodori, Igor A. Schepetkin, Mark T. Quinn, Samuele Ciattini,Patrizia Rossi, Paola Paoli (2020). New 3-unsubstituted Isoxazolones as Potent Human Neutrophil Elastase Inhibitors: Synthesis and Molecular Dynamic Simulation. DRUG DEVELOPMENT RESEARCH, vol. 81, pp. 338-349, ISSN:1098-2299 DOI Accesso ONLINE all'editore

Rossi P.; Paoli P.; Milazzo S.; Chelazzi L.; Giovannoni M.P.; Guerrini G.; Ienco A.; Valleri M.; Conti L. (2020). A combined crystallographic and computational study on dexketoprofen trometamol dihydrate salt. CRYSTALS, vol. 10, pp. 1-14, ISSN:2073-4352 DOI

Crocetti L.; Quinn M.T.; Schepetkin I.A.; Giovannoni M.P. (2019). A patenting perspective on human neutrophil elastase (HNE) inhibitors (2014-2018) and their therapeutic applications. EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 29, pp. 555-578, ISSN:1354-3776 DOI

Guerrini, Gabriella; Vergelli, Claudia; Cantini, Niccolò; Giovannoni, Maria; Daniele, Simona; Mascia, Maria Paola; Martini, Claudia; Crocetti, Letizia (2019). Synthesis of New GABAA Receptor Modulator with Pyrazolo[1,5-a]quinazoline (PQ) Scaffold. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 20, pp. 1438-1457, ISSN:1422-0067 DOI

Cilibrizzi A.; Floresta G.; Abbate V.; Giovannoni M.P. (2019). iVS analysis to evaluate the impact of scaffold diversity in the binding to cellular targets relevant in cancer. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 34, pp. 44-50, ISSN:1475-6366 DOI

Giovannoni M.P.; Cantini N.; Crocetti L.; Guerrini G.; Iacovone A.; Schepetkin I.A.; Vergelli C.; Khlebnikov A.I.; Quinn M.T. (2019). Further modifications of 1H-pyrrolo[2,3-b]pyridine derivatives as inhibitors of human neutrophil elastase. DRUG DEVELOPMENT RESEARCH, vol. 2019, pp. 1-12, ISSN:0272-4391 DOI Accesso ONLINE all'editore

Gabriella Guerrini, Letizia Crocetti, Simona Daniele, Antonella Iacovone, Niccolò Cantini,Claudia Martini, Fabrizio Melani, Claudia Vergelli, Maria Paola Giovannoni, (2019). New 3,6-disubstituted pyrazolo[1,5-a]quinazolines as ligands to GABAA receptor subtype. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 56, pp. 1571-1580, ISSN:1943-5193 DOI

Giovannoni, Maria Paola; Schepetkin, Igor A.; Quinn, Mark T.; Cantini, Niccolò; Crocetti, Letizia*; Guerrini, Gabriella; Iacovone, Antonella; Paoli, Paola; Rossi, Patrizia; Bartolucci, Gian Luca; Menicatti, Marta; Vergelli, Claudia (2018). Synthesis, biological evaluation, and molecular modelling studies of potent human neutrophil elastase (HNE) inhibitors. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 33, pp. 1108-1124, ISSN:1475-6366 DOI

Letizia Crocetti, Maria Paola Giovannoni, Igor A. Schepetkinb, Mark T. Quinn, Andrei I. Khlebnikovc, Niccolò Cantini, Gabriella Guerrini, Antonella Iacovone, Elisabetta Teodori, Claudia Vergelli (2018). 1H-pyrrolo[2,3-b]pyridine: a new scaffold for human neutrophil elastase (HNE) inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 26, pp. 5583-5595, ISSN:0968-0896 DOI

Guerrini, Gabriella; Ciciani, Giovanna; Crocetti, Letizia; Daniele, Simona; Ghelardini, Carla; Giovannoni, Maria Paola; Lorenzo Di Cesare Mannelli, ; Martini, Claudia; Vergelli, Claudia (2017). Synthesis and pharmacological evaluation of novel GABAA subtype receptor ligands with potential anxiolytic-like and anti-hyperlagesic effect. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 54, pp. 2788-2799, ISSN:1943-5193 DOI

Vergelli, Claudia; Schepetkin, Igor A.; Ciciani, Giovanna; Cilibrizzi, Agostino; Crocetti, Letizia; Giovannoni, Maria Paola; Guerrini, Gabriella; Iacovone, Antonella; Kirpotina, Liliya N.; Ye, Richard D.; Quinn, Mark T. (2017). Synthesis of five and six-membered N-phenylacetamido substituted heterocycles as formyl peptide receptor agonists. DRUG DEVELOPMENT RESEARCH, vol. 78, pp. 49-62, ISSN:1098-2299 DOI

Vergelli, C; Schepetkin, I. A.; Crocetti, L.; Iacovone, A.; Giovannoni, M. P.; Guerrini, G.; Khlebnikov, A. I.; Ciattini, S.; Ciciani, G.; Quinn, M. T. (2017). Isoxazolo-5(2H)-one: a new scaffold for potent human neutrophil elastase (HNE) inhibitors. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 32, pp. 821-831, ISSN:1475-6366 DOI

Guerrini, Gabriella; Ciciani, Giovanna; Crocetti, Letizia; Daniele, Simona; Ghelardini, Carla; Giovannoni, MARIA PAOLA; Iacovone, Antonella; DI CESARE MANNELLI, Lorenzo; Martini, Claudia; Vergelli, Claudia (2017). Identification of a new pyrazolo[1,5-a]quinazoline ligand highly affine to γ-aminobutyric type A (GABAA) receptor subtype with anxiolytic-like and antihyperalgesic activity. JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, pp. 9691-9702, ISSN:0022-2623 DOI

Di Cesare Mannelli, Lorenzo; Micheli, Laura; Crocetti, Letizia; Giovannoni, Maria Paola; Vergelli, Claudia; Ghelardini, Carla (2017). α2 Adrenoceptor: a Target for Neuropathic Pain Treatment. MINI-REVIEWS IN MEDICINAL CHEMISTRY, vol. 16, pp. 95-107, ISSN:1875-5607 DOI

Crocetti, Letizia; Bartolucci Gian Luca, ; Cilibrizzi, Agostino; Giovannoni, Maria Paola; Guerrini, Gabriella; Iacovone, Antonella; Menicatti, Marta; Schepetkin, Igor A; Khlebnikov, Andrei I; Quinn, Mark T; Vergelli, Claudia (2017). Synthesis and analytical characterization of new thiazol-2-(3H)-ones as human neutrophil elastase (HNE) inhibitors. CHEMISTRY CENTRAL JOURNAL, vol. 11, pp. 127-141, ISSN:1752-153X DOI

Gabriella Guerrini; Giovanna Ciciani; Samuele Ciattini; Letizia Crocetti; Simona Daniele; Claudia Martini; Fabrizio Melani; Claudia Vergelli; Maria Paola Giovannoni (2016). Pyrazolo[1,5-a]quinazoline scaffold as 5-deaza analogue of pyrazolo[5,1-c][1,2,4]benzotriazine system: synthesis of new derivatives, biological activity on GABAA receptor subtype and molecular dynamic study. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 31, pp. 195-204, ISSN:1475-6366 DOI

Crocetti, Letizia; Schepetkin, Igor A.; Ciciani, Giovanna; Giovannoni, Maria Paola; Guerrini, Gabriella; Iacovone, Antonella; Khlebnikov, Andrei I.; Kirpotina, Liliya N.; Quinn, Mark T.; Vergelli, Claudia (2016). Synthesis and pharmacological evaluation of indole derivatives as deaza analogues of potent human neutrophil elastase inhibitors. DRUG DEVELOPMENT RESEARCH, vol. 77, pp. 285-299, ISSN:1098-2299 DOI

Di Cesare Mannelli, L; Micheli, L; Cinci, L; Maresca, M; Vergelli, C; Pacini, A; Quinn, M.T.; Giovannoni, M. P.; Ghelardini, C. (2016). Effects of the neutrophil elastase inhibitor EL-17 in rat adjuvant-induced arthritis.. RHEUMATOLOGY, vol. 55, pp. 1285-1294, ISSN:1462-0332 DOI

Vergelli, C; Schepetkin, I.A; Ciciani, G; Cilibrizzi, A; Crocetti, L; Giovannoni, M.P; Guerrini, G; Iacovone, A; Kirpotina, L.N; Khlebnikov, A.I; Ye, R.D; Quinn, M.T. (2016). 2-Arylacetamido-4-phenylamino-5-substituted pyridazinones as formyl peptide receptors agonists.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 24, pp. 2530-2543, ISSN:0968-0896

Giovannoni, Maria Paola; Crocetti, Letizia; Ciciani, Giovanna; Cilibrizzi, Agostino; Guerrini, Gabriella; Vergelli, Claudia (2016). Cinnoline derivatives as human neutrophil elastase inhibitors. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 31, pp. 628-639, ISSN:1475-6366 DOI

Claudia Vergelli; Giovanna Ciciani; Agostino Cilibrizzi; Letizia Crocetti; Lorenzo Di Cesare Mannelli; Carla Ghelardini; Gabriella Guerrini; Antonella Iacovone; Maria Paola Giovannoni (2015). Synthesis of five and six-membered heterocycles bearing an arylpiperazinylalkyl side chain as orally active antinociceptive agents. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 23, pp. 6237-6245, ISSN:0968-0896

M. P. Giovannoni;G. Ciciani;A. Cilibrizzi;L. Crocetti;S. Daniele;L. Di Cesare Mannelli;C. Ghelardini;C. Giacomelli;G. Guerrini;C. Martini;M. L. Trincavelli;C. Vergelli (2015). Further studies on pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective human A1 adenosine receptor antagonists.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 89, pp. 32-41, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Schepetkin I.A.; Klebnikov A.I.; Giovannoni M.P.; Kirpotina L.N.; Cilibrizzi A.; Quinn M.T. (2014). Development of small molecule non-peptide formyl peptide receptor (FPR) ligands and molecular modeling of their recognition. CURRENT MEDICINAL CHEMISTRY, vol. 21, pp. 1478-1504, ISSN:0929-8673 DOI

A. Cilibrizzi; L. Crocetti; M.P. Giovannoni; A. Graziano; C. Vergelli; G. Bartolucci; G. Soldani; M.T. Quinn; I.A. Schepetkin; C. Faggi. (2013). Synthesis, HPLC enantioresolution and X-ray analysis of a new series of C5-methyl pyridazines as N-formyl peptide receptor (FPR) agonists. CHIRALITY, vol. 25, pp. 400-408, ISSN:0899-0042 DOI

M.P. Giovannoni; I.A. Schepetkin; A. Cilibrizzi; L. Crocetti; A.I. Khlebnikov; C. Dahlgren; A. Graziano; V. Dal Piaz; L.N. Kirpotina; S. Zerbinati; C. Vergelli; M.T. Quinn (2013). Further studies on 2-arylacetamide pyridazin-3(2H)-ones: design, synthesis and evaluation of 4,6-disubstituted analogs as formyl peptide receptors (FPRs) agonists.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 64, pp. 512-528, ISSN:0223-5234 DOI

C. Vergelli; A. Cilibrizzi; L. Crocetti; A. Graziano; V. Dal Piaz; B. Wan; Y. Wang; S. Franzblau; MP Giovannoni. (2013). Synthesis and evaluation as antitubercular agents of 5-arylethenyl and 5-(hetero)aryl-3-isoxazolecarboxylate. DRUG DEVELOPMENT RESEARCH, vol. 74, pp. 162-172, ISSN:0272-4391 DOI

L. Crocetti; I.A. Schepetkin; A. Cilibrizzi; A. Graziano; C. Vergelli; D. Giomi; A.I. Klebnikov; M.T. Quinn; M.P. Giovannoni (2013). Optimization of N-benzoylindazole derivatives as inhibitors of human neutrophil elastase. JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, pp. 6259-6272, ISSN:1520-4804

L. Crocetti; C. Vergelli; A. Cilibrizzi; A. Graziano; A.I. Khlebnikov; L.N. Kirpotina; I.A. Schepetkin; M.T. Quinn; M.P. Giovannoni. (2013). Synthesis and pharmacological evaluation of new pyridazin-based thioderivatives as formyl peptide receptor (FPR) agonists. DRUG DEVELOPMENT RESEARCH, vol. 74, pp. 259-271, ISSN:0272-4391 DOI

A. Cilibrizzi; I.A. Schepetkin; G. Bartolucci; L. Crocetti; V. Dal Piaz; M.P. Giovannoni; A. Graziano; L. N. Kirpotina; M.T. Quinn; C. Vergelli (2012). Synthesis, enantioresolution and activity profile of chiral 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones as potent N-formyl peptide receptor agonists.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 20, pp. 3781-3792, ISSN:0968-0896 DOI

A. Graziano; M.P. Giovannoni; A. Cilibrizzi; L. Crocetti; V. Dal Piaz; C. Vergelli; M.L. Trincavelli; C. Martini; C. Giacomelli (2012). New pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4-(3H)-ones fluoroderivatives as human A1 adenosine receptor ligands. ACTA CHIMICA SLOVENICA, vol. 59, pp. 648-655, ISSN:1318-0207

M.P. Giovannoni; A. Graziano; R. Matucci; M. Nesi; N. Cesari; C. Vergelli; C. Biancalani; L. Crocetti; A. Cilibrizzi; V. Dal Piaz (2011). Synthesis and evaluation as PDE4 inhibitors of pyrimidine-2,4-dione derivatives. DRUG DEVELOPMENT RESEARCH, vol. 72, pp. 274-288, ISSN:0272-4391 DOI

L. Crocetti; M.P. Giovannoni; I.A. Schepetkin; M.T. Quinn; A.I. Khlebnikov; A. Cilibrizzi; V. Dal Piaz; A. Graziano; C. Vergelli (2011). Design, synthesis and evaluation of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, pp. 4460-4472, ISSN:0968-0896 DOI

P.Biagini; C.Biancalani; A.Graziano; N.Cesari; M.Giovannoni; A.Cilibrizzi; V.Dal Piaz; C.Vergelli; L.Crocetti; M.Delcanale; E.Armani; A.Rizzi; P.Puccini; P.Gallo; D.Spinabelli; P.Caruso (2010). Functionalized pyrazoles and pyrazolo[3,4-d]pyridazinones: synthesis and evaluation of their phosphodiesterase 4 inhibitory activity. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 18, pp. 3506-3517, ISSN:1464-3391

P.Giovannoni; C.Vergelli; A.Graziano; V.Dal PIaz (2010). PDE5 Inhibitors and their applications. CURRENT MEDICINAL CHEMISTRY, vol. 17, pp. 2564-2587, ISSN:0929-8673

M. Giovannoni; C. Vergelli; A. Cilibrizzi; L. Crocetti; C. Biancalani; A. Graziano; V. Dal Piaz; M.I. Loza; M.I Cadavid; J. L. Diaz; A. Gavaldà (2010). Pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as selective human A1 adenosine receptor ligands. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 18, pp. 7890-7899, ISSN:0968-0896

N. Aguilar; J Gràcia; M. Carrascal; V. Dal Piaz; M.P. Giovannoni; C. Vergelli; M. A. Buil; C. Masdeu; Y. Garrido; W. Lumeras; B. Hernandez; M. Cordoba; E. Calaf; M. Andres; M. Miralpeix; A. Gavaldà (2009). Pyridazin-3(2H)-one derivatives as novel PDE IV inhibitors. DRUGS OF THE FUTURE, vol. 34, pp. 133-133, ISSN:0377-8282

V. DAL PIAZ; C. VERGELLI; M.P. GIOVANNONI; C. BIANCALANI; A. CILIBRIZZI; A. GRAZIANO; N. CESARI. (2009). Synthesis and evaluation of novel pyrrolo[2,3-d] and thieno[2,3-d]pyridazinones as in vitro antiproliferative agents. ACTA CHIMICA SLOVENICA, vol. 56, pp. 571-579, ISSN:1318-0207

C. BIANCALANI; M.P.GIOVANNONI; S.PIERETTI; N.CESARI; A.GRAZIANO; C.VERGELLI; A.CILIBRIZZI; A.DI GIANUARIO; M.COLUCCI; G.MANGANO; B.GARRONE; L.POLENZANI; V.DAL PIAZ (2009). Further studies on arylpiperazinyl alkyl pyridazinones: discovery of an exceptionally potent, orally active, antinociceptive agent in thermally induced pain.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, pp. 7397-7409, ISSN:1520-4804

A. CILIBRIZZI; M.T.QUINN; L.N. KIRPOTINA; I.A.SCHEPETKIN; J.HOLDERNESS; R.D.YE; M.J. RABIET; C.BIANCALANI; N. CESARI; A. GRAZIANO; C.VERGELLI; S.PIERETTI; V.DAL PIAZ; M.P.GIOVANNONI. (2009). 6-Methyl-2,4-disubstituted pyridazin-3(2H)-ones: a novel class of small-molecule agonists for formyl peptide receptors.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, pp. 5044-5057, ISSN:1520-4804

M. Giovannoni; C. Ghelardini; C. Vergelli; V. Dal Piaz (2009). Alpha-2-agonist as analgesic agents. MEDICINAL RESEARCH REVIEWS, vol. 29, pp. 339-368, ISSN:0198-6325

C.VERGELLI; M.GIOVANNONI; S.PIERETTI; A.DI GIANNUARIO; V. DAL PIAZ; P.BIAGINI; C.BIANCALANI; A.GRAZIANO; N.CESARI (2007). 4-amino-5-vinyl-3(2H)-pyridazinones and analogues as potent antinociceptive agents: synthesis, SARs, and preliminary studies on the mechanism of action. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 15, pp. 5563-5575, ISSN:0968-0896 DOI

M.GIOVANNONI; N.CESARI; C.VERGELLI; A.GRAZIANO; C.BIANCALANI; P.BIAGINI; C.GHELARDINI; E.VIVOLI; V.DAL PIAZ (2007). 4-Amino-5-substituted-3(2H)-pyridazinones as orally active antinociceptive agents: synthesis and studies on the mechanism of action. JOURNAL OF MEDICINAL CHEMISTRY, vol. 50, pp. 3945-3953, ISSN:0022-2623 DOI

M.GIOVANNONI; N.CESARI; A.GRAZIANO; C.VERGELLI; C.BIANCALANI; P.BIAGINI;V.DAL PIAZ (2007). Synthesis of pyrrolo[2,3-d]pyridazinones as potent, subtype selective PDE4 inhibitors. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 22, pp. 309-318, ISSN:1475-6366 DOI

M.GIOVANNONI; C.VERGELLI; C.BIANCALANI; N.CESARI; A.GRAZIANO; P.BIAGINI; J.GRACIA; A.GAVALDA';V.DAL PIAZ (2006). Novel pyrazolopyrimidopyridazinones with potent and selective phosphodiesterase 5 (PDE5) inhibitory activity agents as potential agents for treatment of erectile dysfunction. JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, pp. 5363-5371, ISSN:0022-2623

N.CESARI; C.BIANCALANI; C.VERGELLI; V. DAL PIAZ; A.GRAZIANO; P.BIAGINI; C.GHELARDINI; N.GALEOTTI; M.GIOVANNONI (2006). Arylpiperazinylalkylpyridazinones and analogues as potent and orally active antinociceptive agents: synthesis and studies on mechanism of action. JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, pp. 7826-7835, ISSN:0022-2623 DOI

V. DAL PIAZ; AGUILAR IZQUIRDO N; BUIL ALBERO M.Z; GARRIDO RUBIO Y; GIOVANNONI M.P; GRACIA FERRER J; LUMERAS AMADOR W; VERGELLI C (2005). Preparation of pyridazin-3(2H)-ones and their use as PDE4 inhibitors. Numero: WO 2005049581 Almirall Prodesfarma

J.FEIXAS; M.GIOVANNONI; C.VERGELLI; A.GAVALDA'; N.CESARI; A. GRAZIANO; V.DAL PIAZ (2005). New pyrazolo[1',5':1,6]pyridazin-4(3H)-ones as potent and selective PDE5 inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, pp. 2381-2384, ISSN:0960-894X DOI

V. DAL PIAZ; AGUILAR IZQUIRDO N; BUIL ALBERO M.A; CARRASCAL RIERA M; GRACIA F; GIOVANNONI M.P; VERGELLI C (2004). Preparation of pyridazin-3(2H)-ones as phosphodiesterase 4 (PDE4) inhibitors. Numero: WO 2004058729 Almirall Prodesfarma

GIOVANNONI M.P.; VERGELLI C.; GHELARDINI C.; GALEOTTI N.; BARTOLINI A.; V. DAL PIAZ (2003). [(3-chlorophenyl)piperazinylpropyl]pyridazinones and analogues as potent antinociceptive agents. JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, pp. 1055-1059, ISSN:0022-2623 DOI

M. GIOVANNONI; V. DAL PIAZ; C. VERGELLI; D. BARLOCCO (2003). SELECTIVE ACAT INHIBITORS AS PROMISING ANTIHYPERLIPIDEMIC, ANTIATHEROSCLEROTIC AND ANTI-ALZHEIMER DRUGS. MINI-REVIEWS IN MEDICINAL CHEMISTRY, vol. 3, pp. 576-584, ISSN:1389-5575

V. DAL PIAZ; GIOVANNONI M.P; VERGELLI C; AGUILAR IZQUIRDO N (2003). preparation of pyridazin-3(2H)-ones as phosphodiesterase 4 (PDE4) inhibitors. Numero: WO 2003097613 Almirall Prodesfarma

V. DAL PIAZ; M. GIOVANNONI; C. VERGELLI; M. SCHEIDELER; G. PETRONE; P. ZARATIN (2003). 4-AMINO-3(2H)-PYRIDAZINONES BEARING ARYLPIPERAZINYLALKYL GROUPS AND RELATED COMPOUNDS: SYNTHESIS AND ANTINOCICEPTIVE ACTIVITY. IL FARMACO, vol. 58, pp. 1063-1071, ISSN:0014-827X

V. DAL PIAZ; M. CASTELLANA; C. VERGELLI; M. GIOVANNONI; V. SEGARRA; J. BELETA; H. RYDER; A. GAVALDA; J. PALACIOS (2002). SYNTHESIS AND EVALUATION OF SOME PYRAZOLO[3,4-D]PYRIDAZINONES AND ANALOGUES AS PDE5 INHIBITORS POTENTIALLY USEFUL AS PERIPHERAL VASODILATOR. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 17, pp. 227-233, ISSN:1475-6366

L. TOMA; M. GIOVANNONI; V. DAL PIAZ; B. KWON; Y. KIM; A. GELAIN; D. BARLOCCO (2002). MONO- AND DI-SUBSTITUTED 5,6-DIPHENYL-3-ALKYLAMINO-PYRIDAZINES ACTIVE AS ACAT INHIBITORS. HETEROCYCLES, vol. 57, pp. 39-46, ISSN:0385-5414

L. TOMA; M. GIOVANNONI; C. VERGELLI; V. DAL PIAZ; Y. KIM; A. GELAIN; D. BARLOCCO; B. KWON (2002). NOVEL 3-ARYLAMINO- AND 3-CYCLOALKYLAMINO-5,6-DIPHENYLPYRIDAZINES ACTIVE AS ACAT INHIBITORS. ARCHIV DER PHARMAZIE, vol. 335, pp. 563-566, ISSN:0365-6233

C. MARTIN; R. GOGGEL; V. DAL PIAZ; C. VERGELLI; M. GIOVANNONI; M. ERNST; S. UHLIG (2002). AIRWAY RELAXANT AND ANTI-INFLAMMATORY PROPERTIES OF A PDE 4 INHIBITOR WITH LOW AFFINITY FOR THE HIGH-AFFINITY ROLIPRAM BINDING SITE. NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY, vol. 365, pp. 284-289, ISSN:0028-1298

V. DAL PIAZ; M. GIOVANNONI; M. CASTELLANA; A. RASCON; M. DUBRA; C. VERGELLI (2002). ISOXAZOLO[3,4-D]PYRIDAZINONES AND ANALOGUES AS LEISHMANIA MEXICANA PDE INHIBITORS. IL FARMACO, vol. 57, pp. 89-96, ISSN:0014-827X

V. DAL PIAZ; PIERETTI S.; VERGELLI C.; CASTELLANA M.C.; GIOVANNONI M.P. (2002). 4-amino-5-vinyl-3(2H)-pyridazinones and related compounds: synthesis and evaluation of antinociceptive activity. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 39, pp. 523-533, ISSN:0022-152X

BARLOCCO D.; CIGNARELLA G.; DAL PIAZ V.; GIOVANNONI M.P.; DE BENEDETTI P.G.; FANELLI F.; MONTESANO F.; POGGESI E.; LEONARDI A.; V. DAL PIAZ (2001). phenylpiperazinylalkylamino substituted pyridazinones as potent alpha 1 adrenoceptor antagonists. JOURNAL OF MEDICINAL CHEMISTRY, vol. 44, pp. 2403-2410, ISSN:0022-2623

GIOVANNONI M.P.; V. DAL PIAZ; KWON B.M.; KIM M.K.; KIM Y.K.; TOMA L.; BARLOCCO D.; BERNINI F.; CANAVESI M. (2001). 5,6-diphenylpyridazine derivatives as acyl-CoA:cholesterol acyltranferase inhibitors. JOURNAL OF MEDICINAL CHEMISTRY, vol. 44, pp. 4292-4295, ISSN:0022-2623

L. TOMA; D. NAVA; G. CELENTANO; M. GIOVANNONI; V. DAL PIAZ; B. KWON; Y. KIM; D. BARLOCCO (2000). 5,6-DINITROPHENYL AND 5-AMINOPHENYL-6-NITROPHENYL ANALOGUES OF THE ACAT INHIBITOR 5,6-DIPHENYL-3-ALKYLAMINOPYRIDAZINONES. HETEROCYCLES, vol. 53, pp. 2709-2718, ISSN:0385-5414

V. DAL PIAZ; M. GIOVANNONI (2000). PHOSPHODIESTERASE 4 INHIBITORS, STRUCTURALLY UNRELATED TO ROLIPRAM, AS PROMISING AGENTS FOR THE TREATMENT OF ASTHMA AND OTHER PATHOLOGIES. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 35, pp. 463-480, ISSN:0223-5234

S. PIERETTI; V. DAL PIAZ; R. MATUCCI; M. GIOVANNONI; A. GALLI (1999). ANTINOCICEPTIVE ACTIVITY OF A 3(2H)-PYRIDAZINONE DERIVATE IN MICE. LIFE SCIENCES, vol. 65, pp. 1381-1394, ISSN:0024-3205

L. COSTANTINO; G. RASTELLI; M. GAMBERINI; M. GIOVANNONI; V. DAL PIAZ; P. VIANELLO; D. BARLOCCO (1999). ISOXAZOLO[3,4-D]PYRIDAZIN-7-(6H)-ONE AS A POTENTIAL SUBSTRATE FOR NEW ALDOSE REDUCTASE INHIBITORS. JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, pp. 1894-1900, ISSN:0022-2623

V. DAL PIAZ; G. CICIANI; M. GIOVANNONI; C. VERGELLI (1999). NEW SYNTHESIS OF DIFFERENTLY FUSED PYRIDAZINONQUINOLINES. SYNLETT, vol. 9, pp. 1453-1455, ISSN:0936-5214

V. DAL PIAZ; M. GIOVANNONI; C. CASTELLANA; J. PALACIOS; J. BELETA; T. DOMENECH; V. SEGARRA (1998). HETEROCYCLIC-FUSED 3(2H)-PYRIDAZINONES AS POTENT AND SELECTIVE PDE IV INHIBITORS: FURTHER STRUCTURE-ACTIVITY RELATIONSHIPS AND MOLECULAR MODELLING STUDIES. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, pp. 789-797, ISSN:0223-5234

D. BARLOCCO; V. DAL PIAZ; M. GIOVANNONI; G. CIGNARELLA; P. VIANELLO; S. MALANDRINO; E. BAROCELLI; M. CHIAVARINI; M. IMPICCIATORE (1997). INDENOPYRIDAZINONE DERIVATIVES AS POTENTIAL ANTISECRETORY AND ANTIULCER AGENTS. DRUG DESIGN AND DISCOVERY, vol. 15, pp. 95-103, ISSN:1055-9612

V. DAL PIAZ; M. GIOVANNONI; J. BELETA; V. SEGARRA; C. CASTELLANA; J. PALACIOS; T. DOMENECH (1997). NOVEL HETEROCYCLIC-FUSED PYRIDAZINONES AS POTENT AND SELECTIVE PHOSPHODIESTERASE IV INHIBITORS. JOURNAL OF MEDICINAL CHEMISTRY, vol. 40, pp. 1417-1421, ISSN:0022-2623

V. DAL PIAZ; G. CICIANI; M. GIOVANNONI (1997). SYNTHESIS OF 4,5 FUNCTIONALIZED-2-METHYL-6-(SUBSTITUTED ARYL)-3(2H)-PYRIDAZINONES: A NEW GROUP OF POTENT PLATELET AGGREGATION INHIBITORS. IL FARMACO, vol. 52, pp. 173-178, ISSN:0014-827X

O. AZZOLINA; V. DAL PIAZ; S. COLLINA; M. GIOVANNONI; C. TADINI (1997). CHIRAL RESOLUTION AND ABSOLUTE CONFIGURATION OF THE ENANTIOMERS OF 5-ACETYL-2-METHYL-4-METHYLSULFINYL-6-PHENYL-3(2H)-PYRIDAZINONE AND EVALUATION OF THEIR PLATELET AGGREGATION INHIBITORY ACTIVITY. CHIRALITY, vol. 9, pp. 681-685, ISSN:0899-0042

V. DAL PIAZ; G. CICIANI; M. GIOVANNONI; F. FRANCONI (1996). SYNTHESIS AND EVALUATION AS PLATELET AGGREGATION INHIBITORS OF 6-PHENYL-2,4-SUBSTITUTED-3(2H)-PYRIDAZINONES AND THEIR RIGID ANALOGUES BENZO[H]CINNOLIN-3,5-DIONES. DRUG DESIGN AND DISCOVERY, vol. 14, pp. 53-75, ISSN:1055-9612

V. DAL PIAZ; G. CICIANI; M. GIOVANNONI; G. PETRONE; D. BARLOCCO; G. GIARDINA; G. CLARKE (1996). 4,5-FUNCTIONALIZED 6-PHENYL-3(2H)-PIRIDAZINONES:SYNTHESIS AND EVALUATION OF ANTINOCICEPTIVE ACTIVITY. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 31, pp. 65-70, ISSN:0223-5234

Gualtieri, Fulvio; Conti, G.; Dei, Silvia; Giovannoni, MARIA PAOLA; Nannucci, F.; Romanelli, MARIA NOVELLA; Scapecchi, Serena; Teodori, Elisabetta; Fanfani, L.; Ghelardini, Carla; Giotti, Alberto; Bartolini, Alessandro (1994). Presynaptic Cholinergic Modulators as Potent Cognition Enhancers and Analgesic Drugs. 1. Tropic and 2-Phenylpropionic Acid Esters. JOURNAL OF MEDICINAL CHEMISTRY, vol. 37, pp. 1704-1711, ISSN:0022-2623

V. DAL PIAZ; G. CICIANI; M. GIOVANNONI (1994). 5-ACETYL-2-METHYL-4-NITRO-6-PHENYL-3(2H)-PYRIDAZINONE:VERSATILE PRECURSOR TO HETERO-CONDENSED PYRIDAZINONES. SYNTHESIS, vol. 7, pp. 669-671, ISSN:0039-7881

V. DAL PIAZ; G. CICIANI; M. GIOVANNONI (1994). 4,5-FUNCTIONALIZED-3(2H)PYRIDAZINONES: NEW SYNTHETIC AND PHARMACOLOGICAL ASPECTS. ACTA CHIMICA SLOVENICA, vol. 41, pp. 189-203, ISSN:1318-0207

V. DAL PIAZ; M. GIOVANNONI; R. LAGUNA; E. CANO (1994). SYNTHESIS AND EVALUATION OF SOME 4,5-DISUBSTITUTED 6-PHENYL-3(2H)-PYRIDAZINONES AS HYPOTENSIVE AGENTS. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 29, pp. 249-252, ISSN:0223-5234

V. DAL PIAZ; M. GIOVANNONI; G. CICIANI; C. BECHERUCCI; L. PARENTE (1994). 4-SUBSTITUTED-5-ACETYL-2-METHYL-6-PHENYL-3(2H)PYRIDAZINONES AS PGE2 AND IL-1 RELEASE INHIBITORS FROM MOUSE ADHERENT MACROPHAGES. PHARMACOLOGICAL RESEARCH, vol. 29, pp. 367-371, ISSN:1043-6618

F. GUALTIERI; C. BOTTALICO; A. CALANDRELLA; S. DEI; M. GIOVANNONI; S. MEALLI; M. ROMANELLI; S. SCAPECCHI; E. TEODORI; N. GALEOTTI; C. GHELARDINI; A. GIOTTI; A. BARTOLINI (1994). Presynaptic Cholinergic Modulators as Potent Cognition Enhancers and Analgesic Drugs. 2. 2-Phenoxy-, 2-(phenylthio)- and 2-(phenylamino)alkanoic Acid Esters. JOURNAL OF MEDICINAL CHEMISTRY, vol. 37, pp. 1712-1719, ISSN:0022-2623 DOI

V. DAL PIAZ; M. GIOVANNONI; G. CICIANI (1993). A NEW TWO-STEP PROCEDURE FOR FUNCTIONALIZED-3(2H)-PIRIDAZINONES THROUGH HOMOLYTIC SUBSTITUTION OF 3-CHLOROPYRIDAZINES. TETRAHEDRON LETTERS, vol. 34, pp. 3903-3906, ISSN:0040-4039

V. Dal Piaz; M.P. Giovannoni; G. Ciciani; D. Giomi; R. Nesi (1993). Diels-Alder Reactions on 5-Acetyl-2-methyl-4-nitro-6-phenylpyridazin-3(2H)-one: a New Facet of the Pyridazine System. TETRAHEDRON LETTERS, vol. 34, pp. 161-162, ISSN:0040-4039

V. Dal Piaz; G. Ciciani; G. Turco; M.P. Giovannoni; M. Miceli; R. Pirisino; M. Perretti (1991). 5-Acyl-6-aryl-4-nitro-3(2H)pyridazinones and related 4-amino compounds: synthesis and pharmacological evaluation. JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 80, pp. 341-348, ISSN:0022-3549

V. Dal Piaz; G. Ciciani; M.P. Giovannoni (1991). Isoxazolo[3,4-d]pyridazin-7-(6H)-ones. Synthesis of 3-unsubstituted derivatives: a reinvestigation.. TETRAHEDRON LETTERS, vol. 32, pp. 3229-3230, ISSN:0040-4039

V. Dal Piaz; G. Ciciani; M.P. Giovannoni (1991). New 6-cyano-3-phenyl-1,2,3,4-tetrahydro-1,2-diazepin-5-ones: synthesis and in vitro antitumor activity evaluation.. IL FARMACO, vol. 46, pp. 435-447, ISSN:0014-827X

G. Ciciani; V. Dal Piaz; M.P. Giovannoni (1991). Synthesis and evaluation of in vitro antitumor activity of some substituted 5-pyridazinyl-styrylketones. IL FARMACO, vol. 46, pp. 873-885, ISSN:0014-827X

V. Dal Piaz; G. Ciciani; M.P. Giovannoni (1991). Reductive cleavage of isoxazolo[3,4-d]pyridazinones: a synthetic approach to various 4,5-functionalized 3(2H)-pyridazinones. HETEROCYCLES, vol. 32, pp. 1173-1179, ISSN:0385-5414

V. Dal Piaz; G. Ciciani; MP Giovannoni; G. Turco (1989). New synthetic approach to pyrazolo[3,4-d]pyridazin-7(6H)-one ring system. HETEROCYCLES, vol. 29, pp. 1595-1600, ISSN:0385-5414

Maria Paola GIOVANNONI

Biography

Degree in Pharmaceutical Chemistry and Technology at the University of Florence, with a grade of 110 with honour
Degree in Pharmacy at the University of Florence, with a grade of 110 with honour (1991)
PhD in Medicinal Chemistry at the University of Florence (1995)
Assistant Professor in Medicinal Chemistry (SSD CHIM/08) at the University of Florence (1996-2015)
Associate Professor in Medicinal Chemistry (SSD CHIM/08 now CHEM-07/A), at the University of Florence (from 2015)

Maria Paola GIOVANNONI

Curriculum

Education and career advancement

Degree in Pharmaceutical Chemistry and Technology at the University of Florence, with a grade of 110 with honour
Degree in Pharmacy at the University of Florence, with a grade of 110 with honour (1991)
PhD in Medicinal Chemistry at the University of Florence (1995)
Assistant Professor in Medicinal Chemistry (SSD CHIM/08) at the University of Florence (1996-2015)
Associate Professor in Medicinal Chemistry (SSD CHIM/08 now CHEM-07/A), at the University of Florence (from 2015)

Main activities

Holder of ministerial funds ex 60% (since 2010)
Responsible for agreements with pharmaceutical companies (2010-2015 CHIESI SpA)
PI funding from Ente Cassa di Risparmio (2015)
University tutor for internship in reference to the convention stipulated between the University of Florence and the companies ELI LILLY ITALIA SpA and GSK Vaccines SRL (from 2015 to present)
Scientific tutor of doctoral theses (from 2014 to present)
Full member of the Commission for the State Examinations for Pharmacist (2017-2019)
PCTO responsible for School of Human Health Sciences (SSSU) - Pharmacy Area (from 2019 to present)

Teaching Activities

Teaching activity was carried out at the University of Florence, in the various Degree Courses of the Faculty of Pharmacy and current School of Human Health Sciences (SSSU).

Master’s Degree in Pharmaceutical Chemistry and Technology.

Laboratory assistance and co-teaching on the course Drug Analysis (1996-2009)
Regular teacher of the course Drug Analysis II (currently Drug Analysis III) (2009 to present)

Master’s Degree in Pharmacy

Regular teacher of 2 CFU for the course Pharmaceutical Chemistry I (currently Pharmaceutical and Toxicological Chemistry I) (2000 to present)

Bachelor’s Degree in Herbal Techniques.

Regular teacher of the course Analysis II (2005-2009)

Bachelor’s Degree in Applied Pharmaceutical Sciences

Regular teacher of the course Analysis of Herbal Products II (2009-2011)

Research Activities

Author of more than 110 publications on international journals.

The research activity mainly concerns the design, synthesis and study of compounds acting on biological macromolecules such as enzymes, receptors and channel proteins. The main fields of investigation are:

Human Neutrophil Elastase (HNE) Inhibitors
Formylated Peptide Receptor Ligands (FPRs)
Adenosine receptor antagonists (A1/A3)
Phosphodiesterase IV (PDEIV) Inhibitors
Pannexin 1 (Panx1) channel blockers

Maria Paola GIOVANNONI

Interest

Research Activities

Author of more than 110 publications on international journals.

The research activity mainly concerns the design, synthesis and study of compounds acting on biological macromolecules such as enzymes, receptors and channel proteins. The main fields of investigation are:

Human Neutrophil Elastase (HNE) Inhibitors
Formylated Peptide Receptor Ligands (FPRs)
Adenosine receptor antagonists (A1/A3)
Phosphodiesterase IV (PDEIV) Inhibitors
Pannexin 1 (Panx1) channel blockers