Personale

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English

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Andrea MORANDI

Ruolo attuale:: Professore Associato
SSD:: BIOS-07/A - Biochimica
Afferenza organizzativa:: Dipartimento di Scienze Biomediche, Sperimentali e Cliniche 'Mario Serio'

Recapiti

	0552751234
	andrea.morandi(AT)unifi.it

Ulteriori Recapiti

https://www.sbsc.unifi.it/vp-326-gruppo-morandi.html

Andrea MORANDI

Pubblicazioni

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Tesi di Dottorato

Meattini, Icro; Becherini, Carlotta; Caini, Saverio; Coles, Charlotte E; Cortes, Javier; Curigliano, Giuseppe; de Azambuja, Evandro; Isacke, Clare M; Harbeck, Nadia; Kaidar-Person, Orit; Marangoni, Elisabetta; Offersen, Birgitte V; Rugo, Hope S; Salvestrini, Viola; Visani, Luca; Morandi, Andrea; Lambertini, Matteo; Poortmans, Philip; Livi, Lorenzo (2024). International multidisciplinary consensus on the integration of radiotherapy with new systemic treatments for breast cancer: European Society for Radiotherapy and Oncology (ESTRO)-endorsed recommendations. THE LANCET ONCOLOGY, vol. 25, pp. 0-0, ISSN:1474-5488 DOI

Lorito, Nicla; Subbiani, Angela; Smiriglia, Alfredo; Bacci, Marina; Bonechi, Francesca; Tronci, Laura; Romano, Elisabetta; Corrado, Alessia; Longo, Dario Livio; Iozzo, Marta; Ippolito, Luigi; Comito, Giuseppina; Giannoni, Elisa; Meattini, Icro; Avgustinova, Alexandra; Chiarugi, Paola; Bachi, Angela; Morandi, Andrea (2024). FADS1/2 control lipid metabolism and ferroptosis susceptibility in triple-negative breast cancer. EMBO MOLECULAR MEDICINE, pp. 0-0, ISSN:1757-4684 DOI

Ippolito, Luigi; Duatti, Assia; Iozzo, Marta; Comito, Giuseppina; Pardella, Elisa; Lorito, Nicla; Bacci, Marina; Pranzini, Erica; Santi, Alice; Sandrini, Giada; Catapano, Carlo V; Serni, Sergio; Spatafora, Pietro; Morandi, Andrea; Giannoni, Elisa; Chiarugi, Paola (2024). Lactate supports cell-autonomous ECM production to sustain metastatic behavior in prostate cancer. EMBO REPORTS, pp. 0-0, ISSN:1469-3178 DOI

Bacci, Marina; Lorito, Nicla; Smiriglia, Alfredo; Subbiani, Angela; Bonechi, Francesca; Comito, Giuseppina; Morriset, Ludivine; El Botty, Rania; Benelli, Matteo; López-Velazco, Joanna I; Caffarel, Maria M; Urruticoechea, Ander; Sflomos, George; Malorni, Luca; Corsini, Michela; Ippolito, Luigi; Giannoni, Elisa; Meattini, Icro; Matafora, Vittoria; Havas, Kristina; Bachi, Angela; Chiarugi, Paola; Marangoni, Elisabetta; Morandi, Andrea (2024). Acetyl-CoA carboxylase 1 controls a lipid droplet-peroxisome axis and is a vulnerability of endocrine-resistant ER+ breast cancer. SCIENCE TRANSLATIONAL MEDICINE, vol. 16, pp. 0-0, ISSN:1946-6242 DOI

Kaidar-Person, Orit; Meattini, Icro; Boersma, Liesbeth J; Becherini, Carlotta; Cortes, Javier; Curigliano, Giuseppe; de Azambuja, Evandro; Harbeck, Nadia; Rugo, Hope S; Del Mastro, Lucia; Gennari, Alessandra; Isacke, Clare M; Vestmø Maraldo, Maja; Marangoni, Elisabetta; Nader Marta, Gustavo; Mjaaland, Ingvil; Salvestrini, Viola; Spanic, Tanja; Visani, Luca; Morandi, Andrea; Lambertini, Matteo; Livi, Lorenzo; Coles, Charlotte E; Poortmans, Philip; Offersen, Birgitte V (2023). Essential requirements for reporting radiation therapy in breast cancer clinical trials: An international multi-disciplinary consensus endorsed by the European Society for Radiotherapy and Oncology (ESTRO). RADIOTHERAPY AND ONCOLOGY, pp. 0-0, ISSN:0167-8140 DOI

Smiriglia A.; Lorito N.; Serra M.; Perra A.; Morandi A.; Kowalik M.A. (2023). Sex difference in liver diseases: How preclinical models help to dissect the sex-related mechanisms sustaining NAFLD and hepatocellular carcinoma. ISCIENCE, vol. 26, pp. 0-0, ISSN:2589-0042 DOI Accesso ONLINE all'editore

Salvestrini, Viola; Kim, Kyubo; Caini, Saverio; Alkner, Sara; Ekholm, Maria; Skyttä, Tanja; Becherini, Carlotta; Coles, Charlotte E; Kaidar-Person, Orit; Offersen, Birgitte; de Azambuja, Evandro; Visani, Luca; Cortes, Javier; Harbeck, Nadia; Rugo, Hope S; Isacke, Clare M; Marangoni, Elisabetta; Morandi, Andrea; Lambertini, Matteo; Poortmans, Philip; Livi, Lorenzo; Meattini, Icro (2023). Safety profile of trastuzumab-emtansine (T-DM1) with concurrent radiation therapy: a systematic review and meta-analysis. RADIOTHERAPY AND ONCOLOGY, vol. 186, pp. 0-0, ISSN:0167-8140 DOI

Kowalik, Marta Anna; Taguchi, Keiko; Serra, Marina; Caddeo, Andrea; Puliga, Elisabetta; Bacci, Marina; Koshiba, Seizo; Inoue, Jin; Hishinuma, Eiji; Morandi, Andrea; Giordano, Silvia; Perra, Andrea; Yamamoto, Masayuki; Columbano, Amedeo (2023). Metabolic reprogramming in Nrf2-driven proliferation of normal rat hepatocytes. HEPATOLOGY, pp. 0-0, ISSN:0270-9139 DOI

El-Botty, Rania; Morriset, Ludivine; Montaudon, Elodie; Tariq, Zakia; Schnitzler, Anne; Bacci, Marina; Lorito, Nicla; Sourd, Laura; Huguet, Léa; Dahmani, Ahmed; Painsec, Pierre; Derrien, Heloise; Vacher, Sophie; Masliah-Planchon, Julien; Raynal, Virginie; Baulande, Sylvain; Larcher, Thibaut; Vincent-Salomon, Anne; Dutertre, Guillaume; Cottu, Paul; Gentric, Géraldine; Mechta-Grigoriou, Fatima; Hutton, Scott; Driouch, Keltouma; Bièche, Ivan; Morandi, Andrea; Marangoni, Elisabetta (2023). Oxidative phosphorylation is a metabolic vulnerability of endocrine therapy and palbociclib resistant metastatic breast cancers. NATURE COMMUNICATIONS, vol. 14, pp. 0-0, ISSN:2041-1723 DOI

Becherini, Carlotta; Visani, Luca; Caini, Saverio; Bhattacharya, Indrani S; Kirby, Anna M; Nader Marta, Gustavo; Morgan, Gilberto; Salvestrini, Viola; Coles, Charlotte E; Cortes, Javier; Curigliano, Giuseppe; de Azambuja, Evandro; Harbeck, Nadia; Isacke, Clare M; Kaidar-Person, Orit; Marangoni, Elisabetta; Offersen, Birgitte; Rugo, Hope S; Morandi, Andrea; Lambertini, Matteo; Poortmans, Philip; Livi, Lorenzo; Meattini, Icro (2023). Safety profile of cyclin-dependent kinase (CDK) 4/6 inhibitors with concurrent radiation therapy: A systematic review and meta-analysis. CANCER TREATMENT REVIEWS, vol. 119, pp. 0-0, ISSN:0305-7372 DOI

De Santis, Maria Chiara; Gozzelino, Luca; Margaria, Jean Piero; Costamagna, Andrea; Ratto, Edoardo; Gulluni, Federico; Di Gregorio, Enza; Mina, Erica; Lorito, Nicla; Bacci, Marina; Lattanzio, Rossano; Sala, Gianluca; Cappello, Paola; Novelli, Francesco; Giovannetti, Elisa; Vicentini, Caterina; Andreani, Silvia; Delfino, Pietro; Corbo, Vincenzo; Scarpa, Aldo; Porporato, Paolo Ettore; Morandi, Andrea; Hirsch, Emilio; Martini, Miriam (2022). Lysosomal lipid switch sensitises to nutrient deprivation and mTOR targeting in pancreatic cancer. GUT, pp. 0-0, ISSN:0017-5749 DOI

Visani, Luca; Livi, Lorenzo; Ratosa, Ivica; Orazem, Miha; Ribnikar, Domen; Saieva, Calogero; Becherini, Carlotta; Salvestrini, Viola; Scoccimarro, Erika; Valzano, Marianna; Cerbai, Cecilia; Desideri, Isacco; Bernini, Marco; Orzalesi, Lorenzo; Nori, Jacopo; Bianchi, Simonetta; Morandi, Andrea; Meattini, Icro (2022). Safety of CDK4/6 inhibitors and concomitant radiation therapy in patients affected by metastatic breast cancer. RADIOTHERAPY AND ONCOLOGY, vol. 177, pp. 40-45, ISSN:0167-8140 DOI

Ippolito, Luigi; Comito, Giuseppina; Parri, Matteo; Iozzo, Marta; Duatti, Assia; Virgilio, Francesca; Lorito, Nicla; Bacci, Marina; Pardella, Elisa; Sandrini, Giada; Bianchini, Francesca; Damiano, Roberta; Ferrone, Lavinia; la Marca, Giancarlo; Serni, Sergio; Spatafora, Pietro; Catapano, Carlo V; Morandi, Andrea; Giannoni, Elisa; Chiarugi, Paola (2022). Lactate rewires lipid metabolism and sustains a metabolic-epigenetic axis in prostate cancer. CANCER RESEARCH, pp. canres.0914.2021-canres.0914.2021, ISSN:0008-5472 DOI

Maisano, Domenico; Mimmi, Selena; Dattilo, Vincenzo; Marino, Fabiola; Gentile, Massimo; Vecchio, Eleonora; Fiume, Giuseppe; Nisticò, Nancy; Aloisio, Annamaria; de Santo, Maria Penelope; Desiderio, Giovanni; Musolino, Vincenzo; Nucera, Saverio; Sbrana, Francesca; Andò, Sebastiano; Ferrero, Simone; Morandi, Andrea; Bertoni, Francesco; Quinto, Ileana; Iaccino, Enrico (2022). A novel phage display based platform for exosome diversity characterization. NANOSCALE, pp. 0-0, ISSN:2040-3364 DOI

Meattini, Icro; Livi, Lorenzo; Lorito, Nicla; Becherini, Carlotta; Bacci, Marina; Visani, Luca; Fozza, Alessandra; Belgioia, Liliana; Loi, Mauro; Mangoni, Monica; Lambertini, Matteo; Morandi, Andrea (2022). Integrating radiation therapy with targeted treatments for breast cancer: From bench to bedside. CANCER TREATMENT REVIEWS, vol. 108, pp. 0-0, ISSN:0305-7372 DOI

Grillo E.; Corsini M.; Ravelli C.; Zammataro L.; Bacci M.; Morandi A.; Monti E.; Presta M.; Mitola S. (2021). Expression of activated VEGFR2 by R1051Q mutation alters the energy metabolism of Sk-Mel-31 melanoma cells by increasing glutamine dependence. CANCER LETTERS, vol. 507, pp. 80-88, ISSN:0304-3835 DOI

Lorito, Nicla; Bacci, Marina; Smiriglia, Alfredo; Mannelli, Michele; Parri, Matteo; Comito, Giuseppina; Ippolito, Luigi; Giannoni, Elisa; Bonechi, Martina; Benelli, Matteo; Migliaccio, Ilenia; Malorni, Luca; Chiarugi, Paola; Morandi, Andrea (2020). Glucose Metabolic Reprogramming of ER Breast Cancer in Acquired Resistance to the CDK4/6 Inhibitor Palbociclib. CELLS, vol. 9, pp. 0-0, ISSN:2073-4409 DOI

Kowalik, Marta Anna; Puliga, Elisabetta; Cabras, Lavinia; Sulas, Pia; Petrelli, Annalisa; Perra, Andrea; Ledda-Columbano, Giovanna Maria; Morandi, Andrea; Merlin, Simone; Orrù, Claudia; Sanchez-Martin, Carlos; Fornari, Francesca; Gramantieri, Laura; Parri, Matteo; Rasola, Andrea; Bellomo, Sara Erika; Sebastian, Carlos; Follenzi, Antonia; Giordano, Silvia; Columbano, Amedeo (2020). Thyroid hormone inhibits hepatocellular carcinoma progression via induction of differentiation and metabolic reprogramming. JOURNAL OF HEPATOLOGY, pp. 0-0, ISSN:0168-8278 DOI

Bacci M.; Lorito N.; Smiriglia A.; Morandi A. (2020). Fat and Furious: Lipid Metabolism in Antitumoral Therapy Response and Resistance. TRENDS IN CANCER, pp. 0-0, ISSN:2405-8033 DOI

Bacci M.; Lorito N.; Ippolito L.; Ramazzotti M.; Luti S.; Romagnoli S.; Parri M.; Bianchini F.; Cappellesso F.; Virga F.; Gao Q.; Simoes B.M.; Marangoni E.; Martin L.-A.; Comito G.; Ferracin M.; Giannoni E.; Mazzone M.; Chiarugi P.; Morandi A. (2019). Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer. CELL REPORTS, vol. 28, pp. 104-118.e8, ISSN:2211-1247 DOI Accesso ONLINE all'editore

Comito, G.; Iscaro, A.; Bacci, M.; Morandi, A.; Ippolito, L.; Parri, M.; Montagnani, I.; Raspollini, M.R.; Serni, S.; Simeoni, L.; Giannoni, E.*; Chiarugi, P. (2019). Lactate modulates CD4 + T-cell polarization and induces an immunosuppressive environment, which sustains prostate carcinoma progression via TLR8/miR21 axis. ONCOGENE, vol. 38 (19), pp. 3681-3695, ISSN:0950-9232, Nature Publishing Group: DOI Accesso ONLINE all'editore

Ippolito, Luigi; Morandi, Andrea; Taddei, Maria Letizia; Parri, Matteo; Comito, Giuseppina; Iscaro, Alessandra; Raspollini, Maria Rosaria; Magherini, Francesca; Rapizzi, Elena; Masquelier, Julien; Muccioli, Giulio G; Sonveaux, Pierre; Chiarugi, Paola; Giannoni, Elisa (2019). Cancer-associated fibroblasts promote prostate cancer malignancy via metabolic rewiring and mitochondrial transfer. ONCOGENE, vol. 38, pp. 5339-5355, ISSN:0950-9232 DOI Accesso ONLINE all'editore

Taddei, Maria Letizia*; Cavallini, Lorenzo; Ramazzotti, Matteo; Comito, Giuseppina; Pietrovito, Laura; Morandi, Andrea; Giannoni, Elisa; Raugei, Giovanni; Chiarugi, Paola (2018). Stromal-induced downregulation of miR-1247 promotes prostate cancer malignancy. JOURNAL OF CELLULAR PHYSIOLOGY, vol. 6, pp. 8274-8285, ISSN:0021-9541 DOI Accesso ONLINE all'editore

Chen, Jingjing; Guccini, Ilaria; Mitri, Diletta Di; Brina, Daniela; Revandkar, Ajinkya; Sarti, Manuela; Pasquini, Emiliano; Alajati, Abdullah; Pinton, Sandra; Losa, Marco; Civenni, Gianluca; Catapano, Carlo V.; Sgrignani, Jacopo; Cavalli, Andrea; D'Antuono, Rocco; Asara, John M.; Morandi, Andrea; Chiarugi, Paola; Crotti, Sara; Agostini, Marco; Montopoli, Monica; Masgras, Ionica; Rasola, Andrea; Garcia-Escudero, Ramon; Delaleu, Nicolas; Rinaldi, Andrea; Bertoni, Francesco; Bono, Johann De; Carracedo, Arkaitz; Alimonti, Andrea (2018). Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer. NATURE GENETICS, vol. 50, pp. 219-228, ISSN:1061-4036 DOI Accesso ONLINE all'editore

De Santis, Maria Chiara; Porporato, Paolo Ettore; Martini, Miriam*; Morandi, Andrea (2018). Signaling pathways regulating redox balance in cancer metabolism. FRONTIERS IN ONCOLOGY, vol. 8, pp. 0-0, ISSN:2234-943X DOI Accesso ONLINE all'editore

Ippolito, Luigi; Morandi, Andrea; Giannoni, Elisa; Chiarugi, Paola (2018). Lactate: A Metabolic Driver in the Tumour Landscape. TRENDS IN BIOCHEMICAL SCIENCES, pp. 153-166, ISSN:0968-0004 DOI

Morandi, Andrea; Taddei, Maria Letizia; Chiarugi, Paola; Giannoni, Elisa (2017). Targeting the Metabolic Reprogramming That Controls Epithelial-to-Mesenchymal Transition in Aggressive Tumors. FRONTIERS IN ONCOLOGY, vol. 7:40, pp. 1-19, ISSN:2234-943X DOI Accesso ONLINE all'editore

Morandi, Andrea; Indraccolo, Stefano* (2017). Linking metabolic reprogramming to therapy resistance in cancer. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, vol. 1868, pp. 1-6, ISSN:0304-419X DOI Accesso ONLINE all'editore

Ippolito, Luigi; Marini, Alberto; Cavallini, Lorenzo; Morandi, Andrea; Pietrovito, Laura; Pintus, Gianfranco; Giannoni, Elisa; Schrader, Thomas; Puhr, Martin; Chiarugi, Paola; Taddei, Maria Letizia (2016). Metabolic shift toward oxidative phosphorylation in docetaxel resistant prostate cancer cells.. ONCOTARGET, vol. 7, pp. 61890-61904, ISSN:1949-2553 DOI Accesso ONLINE all'editore

Bacci, M; Giannoni, E; Fearns, A; Ribas, R; Gao, Q; Taddei, Ml; Pintus, G; Dowsett, M; Isacke, Cm; Martin, La; Chiarugi, P; Morandi, A (2016). miR-155 Drives Metabolic Reprogramming of ER+ Breast Cancer Cells Following Long-Term Estrogen Deprivation and Predicts Clinical Response to Aromatase Inhibitors.. CANCER RESEARCH, vol. 76(6), pp. 1615-1626, ISSN:0008-5472 DOI Accesso ONLINE all'editore

Comito, G; Segura, Cp; Taddei, Ml; Lanciotti, M; Serni, S; Morandi, A; Chiarugi, P; Giannoni, E (2016). Zoledronic acid impairs stromal reactivity by inhibiting M2-macrophages polarization and prostate cancer-associated fibroblasts.. ONCOTARGET, vol. ..8, pp. 118-132, ISSN:1949-2553 DOI Accesso ONLINE all'editore

Morandi, A; Giannoni, E.; Chiarugi, P (2016). Nutrient Exploitation within the Tumor–Stroma Metabolic Crosstalk. TRENDS IN CANCER, vol. 2, pp. 736-746, ISSN:2405-8033 DOI Accesso ONLINE all'editore

Andreucci, Elena; Francica, Paola; Fearns, Antony; Martin, Lesley-Ann; Chiarugi, Paola; Isacke, Clare M; Morandi, Andrea (2016). Targeting the receptor tyrosine kinase RET in combination with aromatase inhibitors in ER positive breast cancer xenografts. ONCOTARGET, vol. 7, pp. 80543--80553, ISSN:1949-2553 DOI

Kowalik, Marta Anna; Guzzo, Giulia; Morandi, Andrea; Perra, Andrea; Menegon, Silvia; Masgras, Ionica; Trevisan, Elena; Angioni, Maria Maddalena; Fornari, Francesca; Quagliata, Luca; Ledda-Columbano, Giovanna Maria; Gramantieri, Laura; Terracciano, Luigi; Giordano, Silvia; Chiarugi, Paola; Rasola, Andrea; Columbano, Amedeo (2016). Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis. ONCOTARGET, vol. 7, pp. 32375-32393, ISSN:1949-2553 DOI

Pietrobono, Silvia; Morandi, Andrea; Gagliardi, Sinforosa; Gerlini, Gianni; Borgognoni, Lorenzo; Chiarugi, Paola; Arbiser, Jack L; Stecca, Barbara (2016). Down-Regulation of SOX2 Underlies the Inhibitory Effects of the Triphenylmethane Gentian Violet on Melanoma Cell Self-Renewal and Survival. JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 136, pp. 2059-2069-2069, ISSN:0022-202X DOI

Mattu, Sandra; Fornari, Francesca; Quagliata, Luca; Perra, Andrea; Angioni, Maria Maddalena; Petrelli, Annalisa; Menegon, Silvia; Morandi, Andrea; Chiarugi, Paola; Ledda-Columbano, Giovanna Maria; Gramantieri, Laura; Terracciano, Luigi; Giordano, Silvia; Columbano, Amedeo (2016). The metabolic gene HAO2 is downregulated in hepatocellular carcinoma and predicts metastasis and poor survival. JOURNAL OF HEPATOLOGY, vol. 64, pp. 891-8-898, ISSN:0168-8278 DOI

Giannoni, E; Taddei, Ml; Morandi, A; Comito, G; Calvani, M; Bianchini, F; Richichi, B; Raugei, G; Wong, N; Tang, D; Chiarugi, P. (2015). Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs OXPHOS and prostate cancer metastatic spread. ONCOTARGET, vol. 6(27), pp. 24061-24074, ISSN:1949-2553 DOI Accesso ONLINE all'editore

Morandi, Andrea; Isacke, Clare M (2014). Targeting RET-interleukin-6 crosstalk to impair metastatic dissemination in breast cancer. BREAST CANCER RESEARCH, vol. 16, pp. 301-301, ISSN:1465-542X DOI

Taddei ML; Cavallini L; Comito G; Giannoni E; Folini M; Marini A; Gandellini P; Morandi A; Pintus G; Raspollini MR; Zaffaroni N; Chiarugi P. (2014). Senescent stroma promotes prostate cancer progression: The role of miR-210. MOLECULAR ONCOLOGY, pp. 1729-1746, ISSN:1574-7891 DOI

Barbetti V; Morandi A; Tusa I; Digiacomo G; Riverso M; Marzi I; Cipolleschi MG; Bessi S; Giannini A; Di Leo A; Dello Sbarba P; Rovida E. (2014). Chromatin-associated CSF-1R binds to the promoter of proliferation-related genes in breast cancer cells.. ONCOGENE, pp. 1-6, ISSN:0950-9232 DOI

Morandi A; Chiarugi P (2014). Metabolic implication of tumor:stroma crosstalk in breast cancer.. JOURNAL OF MOLECULAR MEDICINE, vol. 92, pp. 117-126, ISSN:0946-2716 DOI

Rapizzi E; Ercolino T; Fucci R; Zampetti B; Felici R; Guasti D; Morandi A; Giannoni E; Giaché V; Bani D; Chiarugi A; Mannelli M (2014). Succinate dehydrogenase subunit B mutations modify human neuroblastoma cell metabolism and proliferation. HORMONES & CANCER, vol. 5(3), pp. 174-184, ISSN:1868-8497

Taddei ML; Giannoni E; Morandi A; Ippolito L; Ramazzotti M; Callari M; Gandellini P; Chiarugi P (2014). Mesenchymal to amoeboid transition is associated with stem-like features of melanoma cells. CELL COMMUNICATION AND SIGNALING, vol. 24, pp. 1-12, ISSN:1478-811X DOI

Morandi, Andrea; Martin, Lesley-Ann; Gao, Qiong; Pancholi, Sunil; Mackay, Alan; Robertson, David; Zvelebil, Marketa; Dowsett, Mitch; Plaza-Menacho, Ivan; Isacke, Clare M (2013). GDNF-RET signaling in ER-positive breast cancers is a key determinant of response and resistance to aromatase inhibitors. CANCER RESEARCH, vol. 73, pp. 3783-95-3795, ISSN:0008-5472 DOI

Mologni, Luca; Redaelli, Sara; Morandi, Andrea; Plaza-Menacho, Ivan; Gambacorti-Passerini, Carlo (2013). Ponatinib is a potent inhibitor of wild-type and drug-resistant gatekeeper mutant RET kinase. MOLECULAR AND CELLULAR ENDOCRINOLOGY, vol. 377, pp. 1-6-6, ISSN:0303-7207 DOI

A.Morandi;V.Barbetti;M.Riverso;P.Dello Sbarba;E.Rovida (2011). The Colony-Stimulating Factor-1 (CSF-1) Receptor Sustains ERK1/2 Activation and Proliferation in Breast Cancer Cell Lines.. PLOS ONE, vol. 6, pp. e27450-10, ISSN:1932-6203 DOI Accesso ONLINE all'editore

Plaza-Menacho, Iván; Morandi, Andrea; Mologni, Luca; Boender, Piet; Gambacorti-Passerini, Carlo; Magee, Anthony I; Hofstra, Robert M W; Knowles, Phillip; McDonald, Neil Q; Isacke, Clare M (2011). Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 286, pp. 17292-302-17302, ISSN:0021-9258 DOI

Morandi, Andrea; Plaza-Menacho, Ivan; Isacke, Clare M (2011). RET in breast cancer: functional and therapeutic implications. TRENDS IN MOLECULAR MEDICINE, vol. 17, pp. 149-57-157, ISSN:1471-4914 DOI

Plaza-Menacho, I; Morandi, A; Robertson, D; Pancholi, S; Drury, S; Dowsett, M; Martin, L-A; Isacke, C M (2010). Targeting the receptor tyrosine kinase RET sensitizes breast cancer cells to tamoxifen treatment and reveals a role for RET in endocrine resistance. ONCOGENE, vol. 29, pp. 4648-57-4657, ISSN:0950-9232 DOI

E.Rovida; E.Spinelli E; S.Sdelci; V.Barbetti; A.Morandi; S.Giuntoli; P.Dello Sbarba. (2008). ERK5/BMK1 is indispensable for optimal colony-stimulating factor 1 (CSF-1)-induced proliferation in macrophages in a Src-dependent fashion.. JOURNAL OF IMMUNOLOGY, vol. 180, pp. 4166-4172, ISSN:0022-1767 Accesso ONLINE all'editore

Barbetti V, Gozzini A, Rovida E, Morandi A, Spinelli E, Fossati G, Mascagni P, Lübbert M, Dello Sbarba P, Santini V. (2008). Selective anti-leukaemic activity of low-dose histone deacetylase inhibitor ITF2357 on AML1/ETO-positive cells. ONCOGENE, vol. 27, pp. 1767-78-1778, ISSN:0950-9232 DOI Accesso ONLINE all'editore

Andrea MORANDI

Curriculum

APPOINTMENTS/AFFILIATIONS

2021 Associate Professor of Biochemistry

2018-2021 Assistant Professor of Biochemistry (RTD-b)

2016-2018 Fondazione Veronesi Postdoctoral fellowship at University of Florence (UniFi)

2013-2015 Postdoc at UniFI funded by Fondazione Italiana Ricerca Cancro (FIRC)

2010-2013 Postdoc at ICR (Institute of Cancer Research, London, UK)

2010-2012 Tutor in Cell Biology at Imperial College of London (UK)

2007-2008 Visiting PhD student at ICR

2007-2009 PhD student at UniFi

2004-2006 Research intern at the Dipartimento di Patologia e Oncologia Sperimentali at UniFi

EDUCATION

2010 PhD in Experimental and Clinical Oncology, UniFi

2006 Laurea Magistrale in Medical Biotechnologies, 110/110 cum laude at UniFi

2004 Laurea in Biotechnologies, 110/110 cum laude at UniFi

2001 Diploma at Liceo Scientifico Balducci (Firenze), 100/100

MEMBERSHIPS

- Member of the CTS (Comitato Tecnico Sanitario) of the Ministero della Salute

- Faculty of the PhD Program in Biomedical Sciences, University of Florence

- Board Member of “Gruppo Differenziamento e Trasformazione Neoplastica” of the Società Italiana di Biochimica (Biochemistry Italian Society)

- Member of the editorial board of the following journals:

Editorial Board - Scientific Reports; 2017-

Associate Editor - BMC Cancer; 2017-

Associate Editor - Hormones and Cancer; 2017-

Associate Editor in Molecular and Cellular Oncology - Frontiers; 2019-

Guest Associate Editor in Cancer Metabolism - Frontiers; 2019-

Editorial Board - MDPI - Cancers; 2020-

Editorial Board - Taylor & Francis Online - Molecular and Cellular Oncology (MCO); 2020-

- Active Journal reviewer for: Cancer Research, Oncogene, Nature - Scientific Reports; Nature - Communications Biology, Trends in Molecular Medicine, Gene, Biomaterials, Cancer Letters, Carcinogenesis, Oncotarget, Hormones and Cancer, Epigenomics, Endocrine-Related Cancer, Cancer Medicine, NPJ Breast, Breast Cancer Research, BMC Cancer, BMC Biology, Frontiers in Oncology, Molecular Cancer Research, Molecular Cancer Therapeutics, Frontiers in Endocrinology, AIMS Medical Science, Cell Stress, International Journal of Cancer, The FEBS Journal, MDPI – Biology, Breast Cancer Research and Treatment, FASEB J, MDPI- Cancers

- Active referee for International Funding Agencies: Genesis Oncology Trust (New Zealand), Estonian Research Council (Estonia), Breast Cancer Now (UK), FWF funding (Austria), DKFZ-MOST Israel-Cooperation (Germany Israel)

HONOURS AND AWARDS

2021: Organizer of the Metabolism Meets Function meeting

2019: Chairman for the plenary section “Unraveling the role of metabolism in shaping cancer biology”. Metabolism Meets Function meeting

2017: “Guido Berlucchi Foundation Best Oral presentation Prize” awarded during the International EACR-AACR-SIC Meeting.

2017: Scientific Committee of the3rd Annual Meeting of Young SIC Investigator.

2016: “Guido Berlucchi Foundation Best Poster Prize” awarded during the Annual Meeting of the Italian Cancer Society.

2015: International Society for Cancer Metabolism (ISCaM) Young Investigator Award for the best oral communication.

2015: Chairman for the plenary section on “Targeting cancer metabolism and the altered microenvironment”. ISCaM meeting

2014: "Elena Capannini" Award for innovative anticancer therapy

2014: Chairman for the plenary section on “Cancer Microenvironment and inflammation”; SIC (Italian Association for Cancer Research) conference

2014: EACR (European Association of Cancer Research) Meeting Bursary awardee

2013: Chairman for the plenary section on “Cancer Stem Cell”; SIC conference

2013: Morandi et al. Cancer Research paper was included in the highlights 10 exciting ICR discoveries from 2012/13

2013: AACR (American Association of Cancer Research) Scholar-In-Training SIC awardee

2012: Italian Foundation for Cancer Research 3 years fellowship awardee

2012: EACR “Targeted Therapies/Signaling Pathways Symposium" proffered paper awardee

2011: Cover of Trends in Molecular Medicine issue March 2011

GRANTS

2019-2024: AIRC Investigator Grant (role: Principal Investigator)

2021: AIRC Fellowship 2021 (role: Scientific Supervisor of Dr Lorito, postdoctoral fellow of the lab)

2021: Fondazione Annastacatolisa 2021 (role: Scientific Supervisor of Drs Lorito/Subbiani, postdoctoral fellow of the lab)

2019-2021: Gender Medicine - Excellence Department grant (role: Principal Investigator)

2021: Pezcoller Foundation-Società Italiana di Cancerologia 2021 (role: Scientific Supervisor of Dr Bacci, postdoctoral fellow of the lab)

2017-2020: AIRC-ECRF MultiUser Grant (role: Group Leader)

2018: Fondazione Umberto Veronesi postdoc fellowship

2017: Fondazione Umberto Veronesi postdoc fellowship

2016: Fondazione Umberto Veronesi postdoc fellowship

2012: AIRC/ FIRC 3-years fellowship

ORAL PRESENTATIONS

2021: International Society for Cancer Metabolism (ISCAM) Webinar Series 8th Annual Meeting (virtual - online) - invited

2021: 33rd AICC meeting "Dissecting metabolic circuitries in cancer cells and microenvironment: how to learn from bad lessons to develop new therapeutic opportunities" (Torino, IT) - selected

2021: 61st Congress of the Italian Society of Biochemistry (Milano, IT - online) - invited

2019: 4th IFOM Symposium "Breaking Boundaries: Metabolism at the Cross-roads" (Milano, IT) - selected

2019: 61st Annual Meeting Italian Cancer Society "Precision Oncology: from Myth to Reality" (Napoli, IT) - selected

2019: 60th Congress of the Italian Society of Biochemistry (Lecce, IT) - invited

2018: “Signal Transduction in Cancer – ABCD Meeting” (Torino, IT) – selected, AIRC travel bursary

2018: “Pharmacological insights of altered lipid metabolism in oncological, neurological, cardiovascular, and hepatic diseases” (Padova, IT) - invited

2018: "Metabolism meets function 2018 - unraveling the role of metabolism in shaping cancer biology” (Bari, IT) - invited

2018: Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern (Bern, CH) - invited

2018: PhDay – Instituto Oncologico Veneto (Padova, IT) - invited

2018: Dipartimento di Medicina Interna, Università degli Studi di Genova - invited

2017: Breast Cancer Symposium - Cancer du Sein du Cancéropole Grand Ouest, (Nantes, FR) - invited

2017: Workshop “Targeting the metabolic deregulation of cancer: a novel pharmacological approach” (Padova, IT) - invited

2017: Cancer Metabolism symposium at the “EACR-AACR-SIC Special Conference “The Challenges of Optimising Immuno and Targeted Therapies: From Cancer Biology to the Clinic” – selected, best oral prize

2016: DENOTHE Research Center (Firenze, IT) - invited

2016: University of Sussex, Brighton (UK) - invited

2016: “REVOLUTIONARY ROAD Accelerating Conversion of Cancer Biology into Personalized Clinical Oncology” SIC Annual Conference (Verona, IT) – selected, Guido Berlucchi Award

2015: ISCaM meeting - Metabolism and Microenvironmet in Cancer Plasticity (Venezia, IT) – selected, best oral prize

2015: SIC Meeting "Signal transduction and tumor microenvironment: new opportunities for cancer therapy” (Catanzaro, IT) – invited

2012: EACR 22^nd Biennial Congress (Barcelona, ES) – selected, proffered paper