Personale

Recapiti

Orario di ricevimento

Italiano

Curriculum

Pubblicazioni

Insegnamenti

English

Curriculum

Chiara NEDIANI

Ruolo attuale:: Professore Associato
SSD:: BIOS-09/A - Biochimica clinica e biologia molecolare clinica
Afferenza organizzativa:: Dipartimento di Scienze Biomediche, Sperimentali e Cliniche 'Mario Serio'

Recapiti

	0552751203
	chiara.nediani(AT)unifi.it

Chiara NEDIANI

Curriculum

La Prof.ssa Chiara Nediani nasce a Mantova il 25/6/61

1985: si laurea in Scienze Biologiche della Facoltà di
Scienze Matematiche Fisiche e Naturali, Università degli Studi di Firenze con
la votazione di 110/110 e lode

1986- Abilitazione all' esercizio della professione di Biologo

1989- Funzionario Tecnico di ruolo presso il Dipartimento di Scienze Biochimiche dell' Università degli Studi di Firenze;

2001-Ricercatore Confermato di Biochimica Clinica e Biologia Molecolare Clinica (BIO/12) nella Facoltà di Medicina e Chirurgia dell' Università degli Studi di Firenze;

2003-Diploma di specializzazione in Biochimica e Chimica Clinica.

2006- oggi Professore Associato di Biochimica Clinica e Biologia Molecolare Clinica (BIO/12) nella Facoltà di Medicina e Chirurgia dell' Università degli Studi di Firenze.

DIDATTICA: Docente di Biochimica Clinica nei Corsi di Laurea triennali in Tecniche di Laboratorio Biomedico e Dietistica, e nel Corso di laurea Magistrale in Scienza dell' Alimentazione

Docente di Biochimica clinica nella Scuola di Specializzazione di Patologia Clinica e Biochimica Clinica

PRINCIPALI LINEE DI RICERCA

a) meccanismi di regolazione dell'omeostasi intracellulare del calcio nel muscolo scheletrico e cardiaco;

b) aspetti biochimici e meccanismi molecolari del danno miocardico indotto da ischemia-riperfusione in linee cellulari di cardiomioblasti embrionali di ratto H9c2;

c) meccanismi molecolari del danno miocardico indotto in modelli animali sottoposti a sovraccarico di pressione e di volume;

d) studio dei meccanismi indotti dallo stress ossidativo in biopsie umane di cuori espiantati affetti da cardiomiopatie da pazienti sottoposti a trapianto cardiaco ortotopico.

e) aspetti biochimici e meccanismi molecolari indotti dall' sposizione ad aggregati amiloidi in cellule di insulinoma di ratto RIN-5F

f) aspetti biochimici e meccanismi molecolari indotti dal polifenolo oleuropeina su varie linee cellulari (neuroblastoma umano, cardiomiociti, macrofagi, melanoma, colon e gastrico) e su modelli in vivo di tumore al colon

Componente di diverse unità operative di progetti di ricerca:

Progetto CNR "Struttura e funzione di peptidi bioattivi"

Progetti di ricerca scientifica di rilevante interesse nazionale (PRIN)

Insufficienza cardiaca

Lesioni molecolari e metaboliche indotte nel mioocardio dalla riperfusione post-ischemica e meccanismi di protezione" (1998-2000)

Crosstalk intracellulare tra i meccanismi funzionali e metabolici alla base del
rimodellamento cardiaco (2004-2006)

Modificazioni funzionali,biochimiche e molecolari cardiache in un modello murino di blocco del gene HCN4 senoatriale (2007-2009) (Responsabile scientifico locale)

Unraveling hidden culprits for the cardiac arRHYTHMia burden: Modulation of immunoINflammation and inter-cellular SIGnaling as targets for novel tHerapeuTic approaches (Acronym: RHYTHM-INSIGHT)(2018-2021)

Combined nano-based hyperthermia with targeted chemotherapy: a novel challenge for gastrointestinal malignancies (CHANCE)(2023-2025)

An integrated multimodal approach for an in vitro evaluation of the nutraceutical potential of botanical extracts (phytocomplexes)
from Olea europaea L. and Punica granatum fruit (2023-2025)

Progetto Telethon:

Molecular mechanism for altered intracellular calcium handling in human dilated cardiomyopathy " (1999-2001).

Cellular and molecular mechanisms involved in the arrhytmogenesis of hypertrophic cardiomyopathy (2005-2007).

Responsabile scientifico dei progetti di ricerca finanziati dall' Ente Cassa di Risparmio di Firenze dal titolo:

"Effetti dell' acilfosfatasi sull' omeostasi intracellulare del calcio in cardiomiociti di cuori di suino sottoposti a sovraccarico emodinamico acuto" (2003);

"Crosstalk" intracellulare tra stress ossidativo e meccanismi di nsulino-resistenza nello scompenso cardiaco. Relazione tra ventricolo destro e inistro in cuori affetti da cardiomiopatie (2008)

"Attività MonoAminoOssidasica (MAO) nello scompenso cardiaco umano: un possibile "link" tra stress ossidativo e dis-metabolismo energetico" (2010)

" L' oleuropeina aglicone, principale polifenolo presente nell' olio extra vergine d' oliva, potenziale candidato nella terapia dello scompenso cardiaco: uno studi su cellule cardiache overesprimenti monoamminossidasi-A (2015).

E' autore di 74 articoli pubblicati su riviste citate dal Journal Citation Report (2500 citazioni ; h-index 25)

E' impegnata in campagne di divulgazione scientifica di argomenti legati alla alimentazione correlata alla salute attraverso interviste fatte a ISORADIO, a televisioni private e come relatore a Convegni tematici (Nutrimi 2019,2022), Excellence 2022, 2024

Ha organizzato e partecipato come responsabile della parte scientifica all' evento " la Scienza in cucina: dalla teoria la piatto" svoltosi alla fondazione della Scienza e Tecnica, Marzo-Maggio 2017, Firenze

E' membro della Società Italiana di Biochimica clinica e Biologia
molecolare clinica (SiBioC)

Chiara NEDIANI

Pubblicazioni

Legenda

Contributo su rivista |

Articolo su libro |

Libro |

Contributo in atti di convegno (proceeding) |

Brevetto |

Curatela | Altro

Altro |

Tesi di Dottorato

Sofia Chioccioli , Gabriele Rocchetti , Jessica Ruzzolini , Silvia Urciuoli , Francesco Vitali, Gianluca Bartolucci , Marco Pallecchi , Giovanna Caderni, Carlotta De Filippo, Chiara Nediani, Luigi Lucini (2024). Changes in faecal microbiota profile and plasma biomarkers following the administration of an antioxidant oleuropein-rich leaf extract in a rat model mimicking colorectal cancer. ANTIOXIDANTS, vol. 13, pp. 0-0, ISSN:2076-3921 DOI

G. Marcucci, V. Domazetovic, C. Nediani, J. Ruzzolini, C. Favre, ML Brandi. (2023). Oxidative Stress and Natural Antioxidants in Osteoporosis: Novel Preventive and Therapeutic Approaches.. ANTIOXIDANTS, pp. 0-0, ISSN:2076-3921 DOI Accesso ONLINE all'editore

Gabriele Rocchetti, Maria Luisa Callegari, Alice Senizza, Gianluca Giuberti, Jessica Ruzzolini, Annalisa Romani , Silvia Urciuoli, Chiara Nediani, Luigi Lucini (2022). Oleuropein from olive leaf extracts and extra-virgin olive oil provides distinctive phenolic profiles and modulation of microbiota in the large intestine. FOOD CHEMISTRY, vol. 380, pp. 0-0, ISSN:1873-7072 DOI

Urciuoli S., Ruzzolini J., Francesca Ieri, Pamela Vignolini, Nediani C., (2022). Extra-virgin olive oil cardiovascular protection in chronic kidney disease. NUTRIENTS, vol. 14, pp. 1-20, ISSN:2072-6643 DOI

Elena Andreucci, Jessica Ruzzolini, Francesca Bianchini, Giampaolo Versienti, Alessio Biagioni, Matteo Lulli, Daniele Guasti, Patrizia Nardini, Simona Serratì, Francesca Margheri, Anna Laurenzana, Chiara Nediani, Silvia Peppicelli, Lido Calorini (2022). miR-214-enriched extracellular vesicles released by acid-adapted melanoma cells promote inflammatory macrophage-dependent tumor trans-endothelial migration. CANCERS, vol. 14, pp. 0-0, ISSN:2072-6694 DOI

Sara Peri, Jessica Ruzzolini, Silvia Urciuoli, Giampaolo Versienti, Alessio Biagioni, Elena Andreucci, Silvia Peppicelli, Francesca Bianchini, Andrea Bottari, Lido Calorini, Chiara Nediani, Lucia Magnelli, Laura Papucci (2022). An Oleocanthal-Enriched EVO Oil Extract Induces the ROS Production in Gastric Cancer Cells and Potentiates the Effect of Chemotherapy. ANTIOXIDANTS, vol. 11, pp. 1762-1784, ISSN:2076-3921 DOI

Nediani, Chiara; Dinu, Monica (2022). Oxidative Stress and Inflammation as Targets for Novel Preventive and Therapeutic Approaches in Non-Communicable Diseases II. ANTIOXIDANTS, vol. 11, pp. 824-824, ISSN:2076-3921 DOI Accesso ONLINE all'editore

Sofia Chioccioli; Jessica Ruzzolini; Silvia Urciuoli; Gian Luca Bartolucci; Marco Pallecchi; Lido Calorini; Carlotta De Filippo; Francesco Vitali; Chiara Nediani; Francesca Bianchini; Giovanna Caderni (2022). Oleuropein-rich leaf extract affects intestinal microbiota and free fatty acids in Apc-mutant and wt rats. In: 7th MS-Food, Florence (Italy), 5-7 October 2022, Scientific Committee of 7th MS-Food, 5-7 October 2022, Florence (Italy), pp. 68-69.

Dinu, Monica; Pagliai, Giuditta; Scavone, Francesca; Bellumori, Maria; Cecchi, Lorenzo; Nediani, Chiara; Maggini, Niccolò; Sofi, Francesco; Giovannelli, Lisa; Mulinacci, Nadia (2021). Effects of an Olive By-Product Called Pâté on Cardiovascular Risk Factors. JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, vol. 40, pp. 617-623, ISSN:0731-5724 DOI

Jessica Ruzzolini , Sofia Chioccioli , Noemi Monaco , Silvia Peppicelli , Elena Andreucci , Silvia Urciuoli , Annalisa Romani, Cristina Luceri , Katia Tortora , Lido Calorini , Giovanna Caderni , Chiara Nediani , Francesca Bianchini (2021). Oleuropein-rich leaf extract as a broad inhibitor of tumour and macrophage iNOS in an apc mutant rat model. ANTIOXIDANTS, vol. 10, pp. 0-0, ISSN:2076-3921 DOI

Andreucci E, Laurenzana A, Peppicelli S, Biagioni A, Margheri F, Ruzzolini J, Bianchini F, Fibbi G, Del Rosso M, Nediani C, Serratì S, Fucci L, Guida M, Calorini L. (2021). uPAR controls vasculogenic mimicry ability expressed by drug-resistant melanoma cells.. ONCOLOGY RESEARCH, vol. 28, pp. 873-884, ISSN:1555-3906 DOI

Jessica Ruzzolini , Silvia Peppicelli , Francesca Bianchini , Elena Andreucci , Silvia Urciuoli , Annalisa Romani , Katia Tortora , Giovanna Caderni , Chiara Nediani ,Lido Calorini (2020). Cancer glycolytic dependence as an new target of olive leaf extract. CANCERS, vol. 12, pp. 0-0, ISSN:2072-6694 DOI

Silvia Peppicelli, Elena Andreucci, Jessica Ruzzolini, Francesca Bianchini, Chiara Nediani, Claudiu T. Supuran, Lido Calorini (2020). The Carbonic Anhydrase IX inhibitor SLC-0111 as emerging agent against the mesenchymal stem cell-derived pro-survival effects on melanoma cells. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 1185-1193, ISSN:1475-6366 DOI

Lorenzo Santini, Chiara Palandri , Chiara Nediani, Elisabetta Cerbai, Raffaele Coppini (2020). Modelling genetic diseases for drug development: Hypertrophic cardiomyopathy. PHARMACOLOGICAL RESEARCH, vol. 160 Article 105176, pp. 0-0, ISSN:1096-1186 DOI

Ruzzolini J, Laurenzana A, Andreucci E, Peppicelli S, Bianchini F, Carta F, Supuran CT, Romanelli MN, Nediani C, Calorini L. (2020). A potentiated cooperation of carbonic anhydrase IX and histone deacetylase inhibitors against cancer. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 391-397, ISSN:1475-6366 DOI

Chiara Nediani; Lisa Giovannelli (2020). Oxidative Stress and Inflammation as Targets for Novel Preventive and Therapeutic Approches in Non Communicable Diseases. ANTIOXIDANTS, vol. 9, pp. 290-290, ISSN:2076-3921 DOI

F. Margheri, B. Menicacci, A.Laurenzana, M. Del Rosso, G. Fibbi, M. G Cipolleschi, J. Ruzzolini, C. Nediani, A. Mocali, L. Giovannelli. (2019). Oleuropein aglycone attenuates the pro-angiogenic phenotype of senescent fibroblasts: a functional study in endothelial cells. JOURNAL OF FUNCTIONAL FOODS, vol. 53, pp. 219-226, ISSN:1756-4646 DOI

Ruzzolini Jessica, Peppicelli Silvia, Andreucci Elena, Bianchini Francesca, Urciuoli Silvia, Romani Annalisa, Nediani Chiara, Calorini Lido (2019). Oleuropein-enriched olive leaf extract affects BRAF melanoma cells metabolism. In: Polyphenols Applications, International Society of Antioxidants, pp. 109-109.

Annalisa Romani, Francesca Ieri, Silvia Urciuoli, Annalisa Noce, Giulia Marrone, Chiara Nediani, Roberta Bernini (2019). Health Effects of Phenolic Compounds Found in Extra-Virgin Olive Oil, By-Products, and Leaf of Olea europaea L.. NUTRIENTS, vol. 11, pp. 0-0, ISSN:2072-6643 DOI

Silvia Peppicelli, Jessica Ruzzolini, Francesca Bianchini , Elena Andreucci, Chiara Nediani , Anna Laurenzana, Francesca Margheri,Gabriella Fibbi, Lido Calorini (2019). Anoikis resistance as a further trait of acidic-adapted melanoma cells. JOURNAL OF ONCOLOGY, vol. Article ID 8340926, pp. 0-0, ISSN:1687-8469

Chiara Nediani , Jessica Ruzzolini , Annalisa Romani , Lido Calorini (2019). Oleuropein, a bioactive compound from olea europaea L., as a potential preventive and therapeutic agent in non-communicable diseases. ANTIOXIDANTS, vol. 8, pp. 0-0, ISSN:2076-3921 DOI

Caterina Miceli, Yohan Santin, Nicola Manzella, Raffaele Coppini, Andrea Berti, Massimo Stefani, Angelo Parini, Jeanne Mialet-Perez, Chiara Nediani (2018). Oleuropein aglycone protects against MAO-A-induced autophagy impairment and cardiomyocyte death through activation of TFEB.. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, vol. 2018, pp. 0-0, ISSN:1942-0994 DOI

Jessica Ruzzolini, Silvia Peppicelli, Elena Andreucci , Francesca Bianchini , Arianna Scardigli , Annalisa Romani , Giancarlo La Marca , Chiara Nediani , Lido Calorini (2018). Oleuropein, the Main Polyphenol of Olea europaea Leaf Extract, Has an Anti-Cancer Effect on Human BRAF Melanoma Cells and Potentiates the Cytotoxicity of Current Chemotherapies. NUTRIENTS, vol. 10, pp. 1-17, ISSN:2072-6643 DOI

Romani Annalisa, Palmini Gaia, Ieri Francesca, Galli Gianna, Zonefrati Roberto, Nediani Chiara, Brandi Maria Luisa (2018). In vitro test of quercitin solid fractions from red wine on a cellular model of colorectal cancer. In: Polyphenols Applications, ISANH, pp. 128-128, ISBN:9782356090126

JESSICA RUZZOLINI, SILVIA PEPPICELLI, FRANCESCA BIANCHINI, ELENA ANDREUCCI, ARIANNA SCARDIGLI, ANNALISA ROMANI, CHIARA NEDIANI, LIDO CALORINI (2018). Oleuropein affects braf melanoma cells and potentiates chemotherapy cytotoxicity. In: Polyphenols Applications, Bonn, 25-28 September 2018, ISANH, pp. 147-147, ISBN:9782356090126

J. Ruzzolini, S. Peppicelli, F.Bianchini, E. Andreucci, C. Nediani, L. Calorini. (2017). Oleuropein potentiates the cytotoxic activity of dacarbazine against melanoma cells.. In: Cancer Bio-Immunotherapy, NIBIT, pp. 0-0.

Luccarini, I; Pantano, D; Nardiello, P; Cavone, L; Lapucci, A; Miceli, C; Nediani, C; Berti, A; Stefani, M; Casamenti, F (2016). The polyphenol oleuropein aglycone modulates the PARP1-SIRT1 interplay: an in vitro and in vivo study. JOURNAL OF ALZHEIMER'S DISEASE, vol. 54, pp. 0-0, ISSN:1387-2877 DOI

Manni, Elena Maria; Rigacci, Stefania; Borchi, Elisabetta; Bargelli, Valentina; Miceli, Caterina; Giordano, Carla; Raimondi, Laura; Nediani, Chiara (2016). Monoamine oxidase is over-activated in left and right ventricles from ischemic hearts: an intriguing therapeutic target.. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, vol. 2016, pp. 0-0, ISSN:1942-0900 DOI

Pisano, Annalinda; Cerbelli, Bruna; Perli, Elena; Pelullo, Maria; Bargelli, Valentina; Preziuso, Carmela; Mancini, Massimiliano; He, Langping; Bates, Mattwhe G; Lucena, Joaquin R; Monica, Paola Lilla Della; Familiari, Giuseppe; Petrozza, Vincenzo; Nediani, Chiara; Taylor, Robert W; D'Amati, Giulia; Giordano, Carla (2016). Impaired mitochondrial biogenesis is a common feature to myocardial hypertrophy and end stage ischemic heart failure. CARDIOVASCULAR PATHOLOGY, vol. 25, pp. 103-112, ISSN:1054-8807 DOI

C. Miceli, Y. Santin, N. Manzella, A. Berti, M. Stefani, F. Lezoualc’h, A. Parini, C. Nediani, J Mialet-Perez. (2016). Oleuropein aglycone induces autophagy in neonatal rat cardiomyocytes. Evidences of beneficial effects in an “in vitro” model of cardiomyopathy characterized by autophagy.. In: 6th Annual Scientific Days on Autophagy, CFATG, pp. 26-26.

C. Miceli, S. Rigacci, EM. Manni, V. Bargelli, C. Giordano, L. Raimondi, C. Nediani. (2016). Monoamine oxidase is overactivated in the human left and right ventricles from ischemic hearts: an intriguing therapeutic target.. CARDIOVASCULAR RESEARCH, vol. 111, pp. 117-117, ISSN:0008-6363

Rigacci, Stefania; Miceli, Caterina; Nediani, Chiara; Berti, Andrea; Cascella, Roberta; Pantano, Daniela; Nardiello, Pamela; Luccarini, Ilaria; Casamenti, Fiorella; Stefani, Massimo (2015). Oleuropein aglycone induces autophagy via the AMPK/mTOR signalling pathway: A mechanistic insight. ONCOTARGET, vol. 6, pp. 35344-35357, ISSN:1949-2553 DOI Accesso ONLINE all'editore

C. Miceli, C. Nediani, A.Berti, M.Stefani, S. Rigacci (2015). Oleuropein aglycone induces autophagy in neuroblastoma cells: a mechanicistic insight.. In: Polyphenols Applications, ISANH, pp. 155-155, ISBN:9782356090737

Elisabetta Borchi; Valentina Bargelli; Valentina Guidotti; Andrea Berti; Massimo Stefani; Chiara Nediani; Stefania Rigacci (2014). Mild exposure of RIN-5F β-cells to human islet amyloid polypeptide aggregates upregulates antioxidant enzymes via NADPH oxidase-RAGE: An hormetic stimulus. REDOX BIOLOGY, vol. 2, pp. 114-122, ISSN:2213-2317 DOI

Sandro Gelsomino, Fabiana Lucà, Chiara Nediani, Sandra Zecchi Orlandini, Daniele Bani, Antonio S Rubino, Attilio Renzulli, Roberto Lorusso, Andrea Consolo, Antonino Lo Cascio, Jos Maessen, Gian Franco Gensini (2013). Early Hemodynamic and Biochemical Changes in Overloaded Swine Ventricle.. TEXAS HEART INSTITUTE JOURNAL, vol. 40, pp. 235-245, ISSN:0730-2347 Accesso ONLINE all'editore

Villeneuve C; Guilbeau-Frugier C; Sicard P; Lairez O; Ordener C; Duparc T; De Paulis D; Couderc B; Spreux-Varoquaux O; Tortosa F; Garnier A; Knauf C; Valet P; Borchi E; Nediani C; Gharib A; Ovize M; Delisle MB; Parini A; Mialet-Perez J (2013). p53-PGC-1α Pathway Mediates Oxidative Mitochondrial Damage and Cardiomyocyte Necrosis Induced by Monoamine Oxidase-A Upregulation: Role in Chronic Left Ventricular Dysfunction in Mice.. ANTIOXIDANTS & REDOX SIGNALING, vol. 18, pp. 5-18, ISSN:1523-0864 DOI

C. Nediani; L. Raimondi; E. Borchi; E. Cerbai (2012). Nitric oxide/reactive oxygen species generation and nitroso/redox imbalance in heart failure: From molecular mechanisms to therapeutic implications. ANTIOXIDANTS & REDOX SIGNALING, vol. 14(2), pp. 289-331, ISSN:1523-0864 DOI

E. Borchi; V. Bargelli; F. Stillitano; C. Giordano; M. Sebastiani; PA. Nassi; G.d'Amati; E .Cerbai; C. Nediani (2010). Enhanced ROS production by NADPH oxidase is correlated to changes in antioxidant enzyme activity in human heart failure. BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE, vol. 1802, pp. 331-338, ISSN:0925-4439 DOI

S.Rigacci;V.Guidotti;M.Bucciantini;M.Parri;C.Nediani;E.Cerbai;M.Stefani;A.Berti (2010). Oleuropein aglycon prevents cytotoxic amyloid aggregation of human amylin. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, vol. 21, pp. 726-735, ISSN:0955-2863 DOI

Borchi E; Manni ME; Bargelli V; Giordano C; D'amati G; Cerbai E; Nediani C; Raimondi L (2010). Monoamine oxidase in end-stage heart failure associated with dilated and ischemic cardiomyopaties: a comparison between left and right ventricles.. In: "Frontiers in Cardiovascular Biology", Berlin (Germany), July 16th-19th 2010, OXford journal, vol. 87, pp. S125-S125.

E. Borchi; ME Manni; V. Bargelli; C. Nediani; E. Cerbai;L. Raimondi (2010). Monoamine oxidase activity in end-stage heart failure associated with dilated and ischemic cardiomyopathies: a comparison between left and right ventricles. CARDIOVASCULAR RESEARCH, vol. 87, pp. 466-466, ISSN:0008-6363

E. Borchi; V. Bargelli; F. Stillitano; C. Giordano; G. d'Amati; E. Cerbai; C. Nediani (2009). Increased NADPH oxidase activity and alteration in antioxidant enzymes in the right and the left ventricle from human failing heart. EUROPEAN HEART JOURNAL SUPPLEMENTS, vol. 30, pp. 576-576, ISSN:1554-2815

E. Borchi; V. Bargelli; F. Stillitano; C. Giordano; G. d'Amati; E. Cerbai; C. Nediani (2009). Right ventricle from human failing heart is less protected than left ventricle against oxidative stress damage. EUROPEAN JOURNAL OF HEART FAILURE, vol. 8, pp. 75-75, ISSN:1879-0844

E. Borchi; M. Parri; L. Papucci; M. Becatti; N. Nassi; P. Nassi; C. Nediani (2009). Role of NADPH oxidase in H9c2 cardiac muscle cells exposed to simulated ischemia-reperfusion. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. 13(8B), pp. 2724-2735, ISSN:1582-1838 DOI

E. Borchi; V. Bargelli; C. Giordano; G. D'Amati; E. Cerbai; C. Nediani. (2008). Glutathione peroxidase and catalase activities increase in left and right ventricles of human failing heart: an adaptive response to oxidative stress.. In: 16th JMRC Symposium, Krakow, Poland, 5th-7th June, JMRC, vol. Abstracts Book, pp. 73-73.

C. Alfarano; L. Sartiani; C. Nediani; E. Mannucci; A. Mugelli; E. Cerbai; L. Raimondi. (2008). Functional coupling of angiotensin II type 1 receptor with insulin resistance of energy substrate uptakes in immortalized cardiomyocytes (HL-1 cells).. BRITISH JOURNAL OF PHARMACOLOGY, vol. 153, pp. 907-914, ISSN:0007-1188 DOI Accesso ONLINE all'editore

E. Borchi; V. Bargelli; C. Giordano; G. d'Amati; P. Nassi; E. Cerbai; C. Nediani (2008). Human failing heart left ventricle is more protected than right ventricle versus oxidative stress. In: XV Congresso Nazionale della Società Italiana per la Ricerca Cardiovascolare (SIRC), Imola, 9-11 Ottobre 2008, SIRC, vol. Libro Abstracts, pp. 41-41.

E. Borchi; R. Favilli; M. Parri; P. Nassi; C. Nediani. (2008). Role of NADPH oxidase in H9c2 cardiac muscle cells exposed to a simulated ischemia-reperfusion.. In: 8th Meeting of France-New EU Members, 16th JMRC Symposium, Krakow, Poland, 5th-7th June, JMRC, vol. Abstracts Book, pp. 83-84.

E. Borchi; C. Nediani; R. Favilli; P. Nassi (2007). Inhibition of NADPH oxidase during ischemia-reperfusion protects rat cardiomyoblasts from cellular death.. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, vol. 42, pp. S204-S204, ISSN:0022-2828

C. Nediani; E. Borchi; G.d’ Amati; A. Mugelli; E. Cerbai (2007). NADPH oxidase is related with lipid peroxidation and redox-sensitive kinase activaction in human failing hearts. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, vol. vol 42, pp. S153-S153, ISSN:0022-2828

M. SEBASTIANI ; C. GIORDANO ; C. NEDIANI; C. TRAVAGLINO ; E.BORCHI; M. ZANI ; M. FECCIA ; M.MANCINI ; V.PETROZZA ; A.COSSARIZZA ; P.GALLO ; R.TAYLOR ; G.D'AMATI (2007). Induction of mitochondrial biogenesis is maladaptive mechanisms in mitochondrial cardiomyopathy. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 50, pp. 1362-1369, ISSN:0735-1097, Attuale:ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, USA, NY, 10010-1710 W B Saunders Company:Fulfillment Department, The Curtis Center, Independence Square West:Philadelphia, PA 19106:(800)654-2452, (215)238-7800, EMAIL: wbspcs@harcourt.com, INTERNET: http://elsevierhealth.com, Fax: (215)238-6445: DOI

M. Sebastiani; C. Giordano; C. Travaglino; M. Zani; C. Nediani; E. Borchi; M. Mancini; R. Taylor; P. Gallo; G. d’ Amati. (2007). Induction of mitochondrial biogenesis is a maladaptive mechanism in cardiac remodelling.. VIRCHOWS ARCHIV, vol. 451, pp. 0-0, ISSN:0945-6317

NEDIANI C; BORCHI E; GIORDANO C; BARUZZO S; PONZIANI V; SEBASTIANI M; NASSI P; MUGELLI A; D'AMATI G; E. CERBAI (2007). NADPH oxidase-dependent redox signaling in human heart failure: relationship between the left and right ventricle.. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, vol. 42, pp. 826-834, ISSN:0022-2828, Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010: DOI

Nediani, C.; Borchi, E.; Giordano, C.; Sebastiani, M.; Nassi, * P.; Mugelli, A.; D’Amati, G.; Cerbai, E. (2007). NADPH oxidase is related with lipid peroxidation and redox-sensitive kinase activation in human failing hearts. In: XIX World Congress of the International Society for Heart Research (ISHR), Bologna, 22-26 June, Elsevier, vol. 42, pp. S153-S153.

E. BORCHI; S. BARUZZO; A. MICHAHELLES; L. PAPUCCI; C. NEDIANI; P. NASSI. (2006). NADPH oxidase-dependent redox signalling in ischemia-reperfusion of H9c2 cardiomyoblasts. In: XIII Congresso Nazionale della Società di Ricerche Cardiovascolari ., Imola, 21-23 Settembre 2006, SIRC, vol. Libro Abstract, pp. 65-65.

C. FIORILLO; C. NEDIANI; V. PONZIANI; L. GIANNINI; A. CELLI; N. NASSI; L. FORMIGLI; A.M. PERNA; P. NASSI (2005). Cardiac volume overload rapidly induces oxidative stress-mediated myocyte apoptosis and hypertrophy. BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE, vol. 1741, pp. 173-182, ISSN:0925-4439 DOI

C. NEDIANI; A. CELLI; C. FIORILLO; V. PONZIANI; L. GIANNINI; V. VITALE; L. FORMIGLI; A. PERNA; P. NASSI. (2004). Cross talk between calcium and oxidative stress in inducing apoptosis and hypertrophy in acute volume overloaded heart.. In: EMBO Workshop on Calcium signalling and disease, Capri, 20-23 Settembre 2004, EMBO, vol. Libro Abstracts, pp. 78-78.

A. CELLI; FIORILLO C; V. PONZIANI; L. GIANNINI; C. NEDIANI; N. NASSI; A.M. PERNA; P.A. NASSI. (2003). Cardiomyocyte apoptosis and oxidative stress in acute volume overloaded swine hearts. In: 35° Congresso Nazionale della Società Italiana di Biochimica Clinica e Biologia Molecolare Clinica, Firenze, 14-17 0ttobre, vol. Vol. 27, Supplemento 3, pp. 155-155.

Nediani, C; Celli, A; Formigli, L; Perna, A M; Fiorillo, C; Ponziani, V; Ibba-Manneschi, L; Zecchi-Orlandini, S; Nosi, D; Liguri, G; Modesti, P A; Nassi, P (2003). Possible role of acylphosphatase, Bcl-2 and Fas/Fas-L system in the early changes of cardiac remodeling induced by volume overload. BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1638, pp. 217-226, ISSN:0006-3002 DOI

C. NEDIANI; A. CELLI; C. FIORILLO; V. PONZIANI; L. GIANNINI; P. NASSI (2003). Acylphosphatase interferes with SERCA2a-PLN association.. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 301, pp. 948-951, ISSN:0006-291X DOI

C. FIORILLO; V. PONZIANI; L. GIANNINI; C. CECCHI; A. CELLI; C. NEDIANI; A. PERNA; P. LIGUORI; N. NASSI; L. FORMIGLI; A. TANI; P. NASSI (2003). Beneficial Effects of Poly (ADP-ribose) Polymerase Inhibition Against the Reperfusion Injury in Heart Transplantation. FREE RADICAL RESEARCH, vol. 37, pp. 331-339, ISSN:1071-5762 DOI

F. Tadini-Buoninsegni; P. Nassi; C. Nediani; A. Dolfi; R. Guidelli (2003). Investigation of Na+, K+-ATPase on a solid supported membrane: the role of acylphosphatase on the ion transport mechanism. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, vol. 1611, pp. 70-80, ISSN:0005-2736

A. CELLI; C. NEDIANI; L. NICCOLAI; P. NASSI (2003). Phospholamban displacement from SERCA2a by acylphosphatase. In: Fifth European Symposium of the Protein Society, Firenze, 29 Marzo-2 Aprile, vol. Vol.12, pp. 135-135.

L. Formigli; L. Ibba-Manneschi ;A.M. Perna ; A. Pacini ; L. Polidori; C. Nediani ; P.A. Modesti ; D. Nosi ; A. Tani ; A. Celli; G.G. Neri-Serneri ; F. Quercioli ; S. Zecchi-Orlandini (2003). Altered Cx43 expression during myocardial adaptation to acute and chronic volume overloading. HISTOLOGY AND HISTOPATHOLOGY, vol. 18, pp. 359-369, ISSN:0213-3911

V. PONZIANI; C. FIORILLO; L. GIANNINI; A. CELLI; C. CECCHI; C. NEDIANI; P. NASSI (2003). PJ34 affects the mode of cell death in hypoxic-reoxygenated H9C2 cells. EUROPEAN JOURNAL OF HISTOCHEMISTRY, vol. Vol.47, pp. 7-7, ISSN:1121-760X

C. FIORILLO; V. PONZIANI; L. GIANNINI; C. CECCHI; A. CELLI; N. NASSI; C. NEDIANI; P. NASSI (2003). PJ34 exerts beneficial effects on cell injury induced by hypoxia and reoxygenation in cardiomyoblasts. ITALIAN JOURNAL OF BIOCHEMISTRY, vol. vol. 52, pp. 212-212, ISSN:0021-2938

S. ZECCHI; L. IBBA; G.E. ORLANDINI; A. TANI; C. NEDIANI; L. POLIDORI; A.M. PERNA; L. FORMIGLI (2002). Early adaptive response of pig myocardium to increased left ventricle workload: morphological and biochemical remarks. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 107, pp. 293-293, ISSN:1122-6714

V. PONZIANI; C. FIORILLO; L. GIANNINI; C. CECCHI; A. CELLI; N. NASSI; C. NEDIANI; P. NASSI (2002). Poly (ADP-Ribose) polymerase inhibition and cell injury in cardiomyoblasts subjected to hypoxia and reoxygenation. In: 47° Congresso Nazionale Società Italiana di Biochimica e Biologia Molecolare, Joint Symposia with the British Biochemical Society, vol. Vol. 51, pp. 0-0.

C. NEDIANI; A. CELLI; L. FORMIGLI; A. M. PERNA; C. FIORILLO; V. PONZIANI; D. NOSI; S. ZECCHI; P. NASSI (2002). Early modifications in cardiac remodeling after volume-overload. In: 47° Congresso Nazionale Società Italiana di Biochimica e Biologia Molecolare, Joint Symposia with the British Biochemical Society., Palermo, vol. Vol. 51, pp. 0-0.

Fiorillo C; Pace S; Ponziani V; Nediani C; Perna AM; Liguori P; Cecchi C; Nassi N; Donzelli GP; Formigli L; Nassi P. (2002). Poly(ADP-ribose) polymerase activation and cell injury in the course of rat heart heterotopic transplantation.. FREE RADICAL RESEARCH, vol. 36, pp. 79-87, ISSN:1071-5762

V. PONZIANI; C. FIORILLO; L. GIANNINI; C. CECCHI; A. CELLI; N. NASSI; C. NEDIANI; P. NASSI (2002). Inhibition of poly(ADP-Ribose) polymerase protects H9c2 cells against oxidant stress induced by hypoxia and reoxygenation. In: Italian Meeting “ADP-RIBOSYLATION PROCESS”, pp. 0-0.

C. NEDIANI; A. CELLI; L. FORMIGLI; A. M. PERNA; C. FIORILLO; S. ZECCHI; P. NASSI (2002). Early modifications of sarcoplasmic reticulum calcium transport induced in ventricular myocardium by volume-overload. In: XII International Symposium on Calcium-Binding Proteins and Calcium Function in Health and Disease, Cavalese, CB, pp. 0-0.

C. Nediani; L. Formigli; A.M. Perna; A. Pacini; V. Ponziani; P.A. Modesti; L. Ibba; S. Zecchi; C. Fiorillo; C. Cecchi; P. Liguori; G. Fratini; S. Vanni; P. Nassi. (2002). Biochemical changes and their relationship with morphological and functional finding in pig heart subjected to lasting volume-overload: a possible role of Acylphosphatase in the regulation of sarcoplasmic reticulum calcium pump.. BASIC RESEARCH IN CARDIOLOGY, vol. 97, pp. 469-478, ISSN:0300-8428 DOI Accesso ONLINE all'editore

L. FORMIGLI; L. IBBA-MANNESCHI; C. NEDIANI ; E. MARCELLI ; G. FRATINI ; S. ZECCHI-ORLANDINI ; A.M. PERNA (2001). Are macrophages involved in early myocardial reperfusion injury?. ANNALS OF THORACIC SURGERY, vol. 71, pp. 1596-1602, ISSN:0003-4975, Elsevier Science Incorporated / NY Journals:Madison Square Station, PO Box 882:New York, NY 10159:(212)633-3730, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: (212)633-3680:

C. NEDIANI; A. CELLI; L. FORMIGLI; A. M. PERNA; L.IBBA; C. FIORILLO; V. PONZIANI; S. ZECCHI; G. FRATINI; P. NASSI. (2001). Early sequence of sarcoplasmic reticulum modifications in ventricular myocardium after volume-overload.. In: 46° CONGRESSO NAZIONALE SOCIETÀ ITALIANA DI BIOCHIMICA E BIOLOGIA MOLECOLARE., IBST, vol. 17, pp. 0-0.

C. FIORILLO; V. PONZIANI; L. GIANNINI; C. CECCHI; A. CELLI; C. NEDIANI; N. NASSI; P. LIGUORI; F. MATTEUCCI; A. M. PERNA; P. NASSI. (2001). Inhibition of poly (ADP-Ribose) polymerase attenuates oxidative stress damage induced in rat heart by heterotopic transplantation.. In: 46° CONGRESSO NAZIONALE SOCIETÀ ITALIANA DI BIOCHIMICA E BIOLOGIA MOLECOLARE., Siena, 26-29 Settembre, vol. Vol. 17, pp. 188-188.

F. TADINI BUONINSEGNI; A. DOLFI; M.R. MONCELLI; C. NEDIANI; P.NASSI; R. GUIDELLI. (2001). Effects of acylphosphatase on the ion transport mechanism of the Na+,K+-ATPase.. In: 10th International Conference on Bioinorganic Chemistry., Firenze, Elsevier, vol. 86, pp. 448-448.

G. ORLANDINI; L. IBBA; A. TANI; C. NEDIANI; D. NOSI; A.M. PERNA. (2000). Morphofunctional and biochemical modification in pig myocardium in the course of volume-overload.. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. Vol. 105 Supplemento n. 1 al Fasc. 2, pp. 165-165, ISSN:1122-6714

C. Nediani; A. Pacini; A.M. Perna; L. Formigli; S. Zecchi-Orlandini; P. Nassi (2000). Modificazioni nella funzione del reticolo sarcoplasmatico cardiaco indotto in cuori di maiale da sovraccarico di volume: un possibile ruolo dell'acilfosfatasi.. In: Riunione Annuale sezione TUM, Società Italiana di Biochimica (SIB), Firenze, 27 Maggio, SIB, pp. 0-0.

C. Fiorillo; S. Pace; C. Nediani; A. Pacini; V. Ponziani; A.M. Perna; P. Liguori; P. Nassi. (2000). Evidence for poly(ADP-ribose) polymerase activation in ischemic-reperfused pig heart.. In: Basic and clinical enzymology 2000, Napoli, 21-24 Maggio, BCE, pp. 115-115.

C. Nediani; A. Pacini; L. Formigli; A. M. Perna; L. Ibba; S. Zecchi; C. Fiorillo; S. Pace; V. Ponziani; G. Fratini; P. Liguori; P. Nassi. (2000). Changes in sarcoplasmic reticulum activity induced in left ventricle by volume overload. A possible role of acylphosphatase.. In: Basic and Clinical Enzymology ., Napoli, 21-24 Maggio, pp. E2-E2.

C. Cecchi; G. Liguri; A. Pieri; D. Degl'Innocenti; C. Nediani; C. Fiorillo; P. Nassi; G. Ramponi (2000). Interaction between acylphosphatase and SERCA in SH-SY5Y cells. MOLECULAR AND CELLULAR BIOCHEMISTRY, vol. 211, pp. 95-102, ISSN:0300-8177

C.NEDIANI; L.FORMIGLI; AM PERNA; L.IBBA; S.ZECCHI; C. FIORILLO; V.PONZIANI; C.CECCHI; P.LIGUORI; G.FRATINI; P. NASSI (2000). Early changes induced in the left ventricle by pressure overload. An experimental study on swine heart.. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, vol. 32, pp. 131-142, ISSN:0022-2828 DOI

A.M. Perna; P. Liguori; G. Fratini; C. Nediani; A.Pacini; L. Formigli; S. Zecchi; P. Nassi. (2000). Hemodynamic, biochemical and morphologic changes in experimental model of chronic heart failure.. In: 4TH ANNUAL SCIENTIFIC MEETING HEART FAILURE SOCIETY OF AMERICA., vol. Vol.6, n.3, Supplement 2, pp. 11-11.

C. FIORILLO; S. PACE; C. NEDIANI; N. NASSI; PERNA AM; LIGUORI P; NASSI P. (1999). Parp activity is significantly stimulated in ischemic-reperfused rat heart.. In: BIOMEDICINA ‘99, Meeting on Molecular Medicine., Firenze, 22-24 Novembre., pp. 71-71.

A. Pacini; A. Quattrone; M. Denegri; C. Fiorillo; C. Nediani; S. Ramon Y Cajal; P. Nassi (1999). Trascriptional down regulation of poly(ADP-ribose)polymerase gene expression by E1A binding to pRB proteins protects murine keratinocytes from radiation induced apoptosis.. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, pp. 35107-35112, ISSN:0021-9258 DOI

C. Nediani; C. Fiorillo; S. Rigacci; F. Magherini; M. Francalanci; G. Liguri; A. Pacini; P. Nassi (1999). A novel interaction mechanism accounting for different acylphosphatase effects on cardiac and fast twitch skeletal muscle sarcoplasmic reticulum calcium pump. FEBS LETTERS, vol. 443, pp. 308-312, ISSN:0014-5793 DOI

L. IBBA; L. FORMIGLI; C. NEDIANI; G. FRATINI. (1999). Early biochemical and morphological modifications in pig ventricular myocardium after acute pressure overload.. In: LIII CONGRESSO NAZIONALE DELLA SOCIETA' ITALIANA DI ANATOMIA., Milano, 26-29 Settembre, vol. 104, pp. 96-96.

C. NEDIANI; V. PONZIANI; C. FIORILLO; N. NASSI; G. FRATINI; P. LIGUORI; P. NASSI. (1999). Acylphosphatase and sarcoplasmic reticulum function in heart pressure overload.. In: IFCC-World Lab, Satellite Meeting n.10: Novel aspects of enzymes in human disease., Venice, 4-6 Giugno 1999, vol. Abstract Book, pp. 22-22.

C. FIORILLO; S. PACE; C. NEDIANI; A.M. PERNA; P. LIGUORI; P. NASSI. (1999). Oxidative stress and PARP levels in ischemic-reperfused rat heart. In: 44° CONGRESSO NAZIONALE SOCIETÀ ITALIANA DI BIOCHIMICA E BIOLOGIA MOLECOLARE, Alghero, vol. 13, pp. 221-221.

P. Nassi; C. Nediani; C. Fiorillo; A. Pacini; G. Liguri; C. Cecchi; S. Zecchi; A. Perna. (1999). Molecular mechanisms for altered intracellular calcium handling in human dilated cardiomyopathy.. In: Comitato Telethon Fondazione Onlus, Scientific Convention., Rimini, 14-16 Novembre, pp. 296-296.

C. NEDIANI; L. FORMIGLI; A.M. PERNA; L. IBBA; S. ZECCHI; C. FIORILLO; V. PONZIANI; G. FRATINI; P. NASSI. (1999). Changes in sarcoplasmic reticulum function, morphological and hemodynamic alterations in pig heart during the early phase of pressure overload.. In: BIOMEDICINA ‘99, Meeting on Molecular Medicine., Firenze, 22-24 Novembre., pp. 72-72.

L. IBBA; L. FORMIGLI; A. PERNA; C. NEDIANI; G. ORLANDINI; S. ZECCHI. (1998). Monocytes as mediators of myocardial ischemia-reperfusion syndrome.. In: LII CONGRESSO NAZIONALE DELLA SOCIETA' ITALIANA DI ANATOMIA., Palermo, 4-7 Ottobre 1998, vol. Supplemento al Vol. 103, pp. 4-4.

L. FORMIGLI; L. IBBA-MANNESCHI; A.M. PERNA; C. NEDIANI; P. LIGUORI; A. TANI; S. ZECCHI-ORLANDINI (1998). Ischemia-reperfusion induced apoptosis and p53 expression in the course of rat heterotopic heart transplantation. MICROVASCULAR RESEARCH, vol. 56, pp. 277-281, ISSN:0026-2862

C. NEDIANI; C. FIORILLO; M. FRANCALANCI; V. PONZIANI; P. NASSI. (1998). Evidence for a novel interaction mechanism between acylphosphatase and cardiac sarcoplasmic reticulum calcium pump.. In: BIOMEDICINA ‘98, Meeting on Molecular Medicine., Firenza, 25-27 Novembre 1998, vol. Libro Abstract, pp. 116-116.

C.Fiorillo ; C.Oliviero ; G.Rizzuti ; C. Nediani; A.Pacini; P.Nassi (1998). Oxidative stress and antioxidant defenses in renal patients receiving regular haemodialysis. CLINICAL CHEMISTRY AND LABORATORY MEDICINE, vol. 36, pp. 149-153, ISSN:1434-6621 DOI

C. FIORILLO; G. LIGURI; M. FRANCALANCI; C. CECCHI; S. LATORRACA; S. SORBI; C. NEDIANI; P.A. NASSI (1998). Alzheimer’s disease lymphoblasts: evidence for oxidative stress. In: BIOMEDICINA ‘98, Meeting on Molecular Medicine, Firenza, 25-27 Novembre, vol. Libro Abstract, pp. 142-142.

C. Nediani; A.M. Perna; C. Fiorillo; G. Rizzuti; A. Pacini; A. Ognibene; P. Nassi (1997). Protection of ischemic and reperfused pig myocardium by the 21-aminosteroid U-74389G.. In: 29° Congresso della Società italiana di Biochimica Clinica e Biologia Molecolare Clinica(SIBioC), Napoli, 4 -7 Novembre, SIBIOC, pp. 48-48.

C. Nediani; C. Fiorillo; A. Pacini; G. Rizzuti; P. Nassi (1997). Different effects of acylphosphatase on skeletal and cardiac muscle sarcoplasmic reticulum calcium pump. In: Meeting on Molecular Medicine, Firenze, 26-28 Novembre, pp. 0-0.

C.NEDIANI; A.M.PERNA; P.LIGUORI; L.FORMIGLI; L.IBBA; S.ZECCHI; C.FIORILLO; G.RIZZUTI; P.NASSI (1997). Beneficial effects of the 21-Aminosteroid U 74389G on the ischemia-reperfusion damage in pig hearts. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, vol. 29, pp. 2825-2835, ISSN:0022-2828 DOI

C. Fiorillo; G. Rizzuti; C. Nediani; A. Pacini; P. Nassi (1997). Oxidative stress and antioxidant defenses in nephropathic patients on hemodialysis. In: 42° CONGRESSO NAZIONALE DELLA SOCIETÀ ITALIANA DI BIOCHIMICA (SIB), ANCONA, pp. 1-1.

C.Nediani; C.Fiorillo; E.Marchetti; A.Pacini; G.Liguri; P.Nassi (1996). Stimulation of cardiac sarcoplasmic reticulum calcium pump by acylphosphatase: relationship to phospholamban phosphorylation.. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, pp. 19066-19073, ISSN:0021-9258

A.M. PERNA; P.LIGUORI; M. BONACCHI; G.M. LAINO; C.NEDIANI; C.FIORILLO; B.LUNGHI; S.ZECCHI; L.FORMIGLI; L.IBBA; P.NASSI (1996). Protection of rat heart from ischaemia-reperfusion injury by the 21-aminosteroid U-74389G.. PHARMACOLOGICAL RESEARCH, vol. 34 (1-2), pp. 25-31, ISSN:1043-6618 DOI

C.Fiorillo ; C. Nediani; E.Marchetti ; A.Pacini ; G.Liguri; P.Nassi (1996). Acylphosphatase stimulates Ca2+-transport and Ca2+-dependent ATPase activity in cardiac sarcoplasmic reticulum. BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL, vol. 39, pp. 387-394, ISSN:1039-9712

E. Marchetti; A. Pacini; S. Ramon Y Cajal; C. Nediani; C. Fiorillo; P. Nassi (1995). Effects of topoisomerase II inhibitors on gamma-radiated murine keratinocytes. In: 40° CONGRESSO NAZIONALE DELLA SOCIETÀ ITALIANA DI BIOCHIMICA (SIB), Torino, 12-15 Settembre, vol. 6, pp. P105-P105.

C. NEDIANI; E. MARCHETTI; C. FIORILLO; N. TADDEI; P. NASSI (1995). Metabolic alterations of cardiac muscle during ischemia. A novel mechanism potentially involved in intracellular calcium overload. In: NERI SERNERI GG, MASOTTI G, MODESTI PA. Heart Failure, pp. 41-49, FIRENZE: NERI SERNERI GG, MASOTTI G, MODESTI PA.

C. NEDIANI; C. FIORILLO; E. MARCHETTI; R. BANDINELLI; D. DEGL'INNOCENTI ; P. NASSI (1995). ACYLPHOSPHATASE: A POTENTIAL MODULATOR OF HEART SARCOLEMMA NA+,K+ PUMP. BIOCHEMISTRY, vol. 34, pp. 6668-6674, ISSN:0006-2960

E. Marchetti; A. Pacini; C. Fiorillo; F. Dolfi; C. Nediani; S. Ramon Y Cajal; P. Nassi (1994). DNA repair activity in keratinocytes transformed by different oncogenes after amma-irradiation. In: 39° CONGRESSO NAZIONALE DELLA SOCIETÀ ITALIANA DI BIOCHIMICA (SIB), Pavia, 14-17 settembre, vol. 5, pp. BA8-BA8.

Nassi P;Nediani C;Fiorillo C;Marchetti E;Liguri G;Ramponi G (1994). Modifications induced by acylphosphatase in the functional properties of heart sarcolemma Na+,K+ pump.. FEBS LETTERS, vol. 337, pp. 109-113, ISSN:0014-5793

P. NASSI; E. MARCHETTI; C. NEDIANI; G. LIGURI; G. RAMPONI (1993). ACYLPHOSPHATASE INDUCED MODIFICATIONS IN THE FUNCTIONAL PROPERTIES OF ERYTHROCYTE MEMBRANE SODIUM PUMP. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, vol. 1147, pp. 19-26, ISSN:0304-4165

C. NEDIANI; E. MARCHETTI; G. LIGURI; P. NASSI (1992). ALTERATIONS INDUCED BY ACYLPHOSPHATASE IN THE ACTIVITY OF HEART SARCOLEMMA CALCIUM PUMP. BIOCHEMISTRY INTERNATIONAL, vol. 26, pp. 715-723, ISSN:0158-5231

P. NASSI; C. NEDIANI; G. LIGURI; N. TADDEI; G. RAMPONI (1991). Effects of acylphosphatase on the activity of erythrocyte memmbrane Ca2+ pump.. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 266, pp. 10867-10871, ISSN:0021-9258

NEDIANI C; G. LIGURI; TADDEI N; MARCHETTI E; RAMPONI G; NASSI P. (1991). Acylphosphatase and calcium transport across erythrocyte membrane.. In: Magnani and De Flora. Red Blood Cell Aging, pp. 207-215 Plenum Press.

C. NEDIANI; G. LIGURI; N. TADDEI; G. RAMPONI; E. MARCHETTI; P. NASSI (1991). ACYLPHOSPHATASE AND CALCIUM TRANSPORT ACROSS ERYTHROCYTE MEMBRANE. In: C. NEDIANI, G. LIGURI, N. TADDEI, G. RAMPONI, E. MARCHETTI, P. NASSI. RED BLOOD CELL AGING, pp. 207-215, New york: M.MAGNANI AND A. DE FLORA.

C. NEDIANI; E. MARCHETTI; P. NASSI; G. LIGURI; G. RAMPONI (1991). HYDROLYSIS BY ACYLPHOSPHATASE OF ERYTHROCYTE MEMBRANE NA+,K+-ATPASE PHOSPHORYLATED INTERMEDIATE. BIOCHEMISTRY INTERNATIONAL, vol. 24, pp. 959-968, ISSN:0158-5231

G.LIGURI ; N.TADDEI ; P.NASSI ; S.LATORRACA ; C. NEDIANI;S. SORBI (1990). Changes in Na+,K+-ATPase, Ca2+-ATPase and some soluble enzymes related to energy metabolism in brains of patients with Alzheimer's disease. NEUROSCIENCE LETTERS, vol. 112, pp. 338-342, ISSN:0304-3940

G.LIGURI ; N.TADDEI ; P.MANAO ; P.NASSI ; C. NEDIANI; U.IKRAM ; G.RAMPONI (1990). ISOLATION AND QUANTITATION OF UBIQUITIN FROM RAT BRAIN. PROTEIN EXPRESSION AND PURIFICATION, vol. 1, pp. 93-96, ISSN:1046-5928

P.NASSI ; G.LIGURI ; C. NEDIANI; N.TADDEI; G.RAMPONI (1990). Increased acylphosphatase levels in erythrocytes, muscle and liver of tri-iodothyronine treated rabbits. HORMONE AND METABOLIC RESEARCH, vol. 22, pp. 33-37, ISSN:0018-5043

P.NASSI ; C. NEDIANI; G.LIGURI ; N.TADDEI ; M.RUGGIERO; G.RAMPONI (1990). Effect of acylphosphatase on human erythrocyte membrane Ca2+-ATPase. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 168, pp. 651-658, ISSN:0006-291X

P.NASSI ; G.LIGURI ; C. NEDIANI; N.TADDEI ; P.PICCINNI ; D.DEGL'INNOCENTI ; R.GHERI; G.RAMPONI (1989). INCREASED ACYLPHOSPHATASE LEVELS IN ERYTHROCYTES FROM HYPERTHYROID PATIENTS. CLINICA CHIMICA ACTA, vol. 183, pp. 351-358, ISSN:0009-8981

G.RAMPONI ; G.LIGURI ; C. NEDIANI; M.STEFANI ; N.TADDEI; P.NASSI (1988). Acylphosphatase increases the rate of ethanol production from glucose in cell-free extract of Saccharomyces cerevisiae. BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, vol. 10, pp. 408-413, ISSN:0885-4513

G.LIGURI ; P.NASSI ; N.TADDEI ; C. NEDIANI (1988). Post-mortem modifications of the specific activity of some brain enzymes. NEUROSCIENCE LETTERS, vol. 85, pp. 244-248, ISSN:0304-3940

C.MAGGI ; P.SANTICIOLI ; P.GEPPETTI ; S.FRILLI ; M.SPILLANTINI ; C. NEDIANI; S.HUNT;A .MELI (1988). Biochemical, anatomical and functional correlates of postnatal development of the capsaicin-sensitive innervation of the rat urinary bladder. BRAIN RESEARCH, vol. 43, pp. 183-190, ISSN:0006-8993

G.LIGURI; P.NASSI ; D.DEGL'INNOCENTI ; E.TREMORI ; C. NEDIANI; A.BERTI; G. RAMPONI (1987). Acylphosphatase levels of human erythrocytes during cell ageing. MECHANISMS OF AGEING AND DEVELOPMENT, vol. 39, pp. 59-67, ISSN:0047-6374

Chiara NEDIANI

Curriculum

1985:Degree in Biological Science, Faculty of Mathematical, Physical and Natural Science, University of Florence

1986:Certificate to practise the profession of Biologist.

1989: Assistant Researcher in the technical-scientific and medical areas, for the Department of Biochemical Science, University of Florence.

2001: Researcher of Clinical Biochemistry and Molecular Biology (BIO/12) in the Faculty of Medicine, University of Florence.

2003: Degree certificate in the Scuola di Specializzazione in Biochimica e Chimica Clinica.

2006:Associate Professor of Clinical Biochemistry and Molecular Biology (BIO/12) in the Faculty of Medicine, University of Florence, Italy.

Today: Confirmed Associate Professor of Clinical Biochemistry and Molecular Biology (BIO/12),University of Florence

Universitary Teacher of Clinical Biochemistry, Schools of Nursing, Technician for Biomedical Laboratory, Dietetics, Biotecnology, Nutrition Science

RESEARCH TOPICS

a) regulatory mechanism of calcium homeostasis in cardiac and skeletal muscle;

b) biochemical aspects and molecular mechanisms of myocardial damage induced by ischemia-reperfusion in cellular line of rat embryonic cardiomyocytes H9c2;

c)molecular mechanisms of myocardial damage induced in animal models undergoing volume and pressure overload;

d) oxidative stress mechanisms in end-stage human failing hearts;

e)biochemical aspects and molecular mechanisms induced by amiloid aggregates exposure in rat insulinoma RIN-5F cells

Component of various research project units:

CNR Project " Structure and function of bioactive peptides"

Project of Relevant National Interest (PRIN):

Heart failure
Molecular and metabolic myocardial damages induced by post ischemic reperfusion and mechanisms of protection (1998-2000)
Intracellular cross talk between functional and metabolic mechanisms in cardiac maladaptation (2004-2006).
Cardiac functional, biochemical and molecular changes in a murine model of blockade of sinoatrial HCN4 gene (2007-2009) Local scientific responsible

Telethon Project:
Molecular mechanism for altered intracellular calcium handling in human dilated cardiomyopathy (1999-2001).
Cellular and molecular mechanisms involved in the arrhytmogenesis of hypertrophic cardiomyopathy (2005-2007)

Scientific responsible of the research project:
Effects of acylphosphatase on intracellular calcium homeostasis in swine heart cardiomyocytes subjected to acute hemodinamic overload (2003) grant from Ente Cassa di Risparmio of Florence

Intracellular "crosstalk" between oxidative stress and insulin resistance mechanisms in human heart failure. Relationship between left and right ventricle affected by cardiomyopathy (2008) grant from Ente Cassa Risparmio di Firenze

Monoamine oxidase activity in human heart failure: a possible link between oxidative stress, energy dismetabolism and cardiac hypertrophy (2010) grant from Ente Cassa Risparmio di Firenze
She is author of 48 papers published on International Journals (IF. 190)

She is a member of the Società Italiana di Biochimica
clinica e Biologia molecolare clinica (SiBioC)