Fabrizio MELANI

Ruolo attuale:: Professore Associato in Pensione
SSD:: CHIM/08 - Chimica farmaceutica
Afferenza organizzativa:: Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino (NEUROFARBA)

Recapiti

	0554573703
	fabrizio.melani(AT)unifi.it

Fabrizio MELANI

Orario di ricevimento (aggiornato al 27/05/2010) Tutti i giorni previo appuntamento.

Fabrizio MELANI

Biografia

Fabrizio Melani è stato un insegnante universitario.

La sua storia lavorativa inizia come chimico in una industria chimica, e successivamente lavora presso l’Università di Firenze con una qualifica di Tecnico. Dopo il conseguimento della laurea in Farmacia assume il ruolo di Professore associato in Chimica Farmaceutica.

L’esperienza lavorativa, volta alla produzione industriale, gli è stata utile per tramettere agli studenti una conoscenza non solo accademica ma il più possibile attinente alla realtà della professione del chimico.

Ha avuto esperienze in campo chimico riguardanti la sintesi di molecole attive in campo biologico e di tecniche analitiche. Ha acquisito anche esperienza nel campo della “chimica virtuale” usando e anche scrivendo algoritmi in grado di simulare e prevedere il comportamento delle molecole in ambiente biologico facendo anche uso sia della statistica che dell’intelligenza artificiale.

Fabrizio Melani è stato, per diversi anni, direttore del Dipartimento di Scienze Farmaceutiche Attualmente, pur essendo collocato in pensione, continua a collaborare con vari gruppi di ricerca sia in campo chimico-farmaceutico che chimico-alimentare. Coltiva la passione per le escursioni in mountain-bike e per la disciplina sportiva del tiro con l’arco facendo parte di una Compagnia di Arcieri di cui è anche Presidente.

Fabrizio MELANI

Curriculum

Formazione

1973: Diploma di Perito Chimico Industriale

1983: Laurea in FARMACIA conseguita presso l'Università di Firenze

Attività professionale e accademica

1976-1981: Assistente Capo Tecnico presso il laboratorio di analisi generali dello stabilimento SOLVAY di Rosignano S.

1981-1992: Tecnico presso l'Università degli Studi di Firenze

1992-2021: Professore associato di Chimica Farmaceutica e Tossicologica presso la Facoltà di Farmacia dell'Università di Firenze.

2009-2012 Direttore del dipartimento di Scienze Farmaceutiche

Attività didattica

1992-1994: Docente di ESERCITAZIONI DI CHIMICA FARMACEUTICA E TOSSICOLOGICA III (corso di laurea in Farmacia)

1994-2000: Docente di CHIMICA FARMACEUTICA E TOSSICOLOGICA III (corso di laurea in CTF)

1999-2021: Docente di ANALISI DEI FARMACI I (corso di laurea in CTF)

2005-2021: Docente di ANALISI DEI MEDICINALI I (corso di laurea in FARMACIA)

2005 a 2008: Docente di MODELLISTICA MOLECOLARE (modulo) (corso di laurea in BIOTECNOLOGIE FARMACEUTICHE)

2010-2021: Docente corso di approfondimento in MOLECULAR MODELING in CHIMICA FARMACEUTICA

Fabrizio MELANI

Interessi

Gli interessi attuali di Fabrizio Melani, sono rivolti verso l’applicazione dell’inteligenza artificiale a supporto di studi di modellistica molecolare e del trattamento di dati analitici nel quadro delle collaborazioni con vari gruppi di ricerca. Al di fuori del campo professionale, i suoi interessi sono rivolti alla natura che si concretizzano in frequenti escursioni e alle attività sportive come la montain-bike e il tiro con l’arco.

Fabrizio MELANI

Pubblicazioni

Legenda

Contributo su rivista |

Articolo su libro |

Libro |

Contributo in atti di convegno (proceeding) |

Brevetto |

Curatela | Altro

Altro |

Tesi di Dottorato

Cecchi, Lorenzo; Migliorini, Marzia; Digiglio, Irene; Ugolini, Tommaso; Trapani, Serena; Zanoni, Bruno; Mulinacci, Nadia; Melani, Fabrizio (2025). Robust application of a chemometric model based on the relationships between 10 volatile compounds and sensory attributes to support the panel test in virgin olive oil quality classification in olive oil companies. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, vol. 141, pp. 0-0, ISSN:0889-1575 DOI Accesso ONLINE all'editore

Breschi, Carlotta; Ieri, Francesca; Calamai, Luca; Miele, Alessandra; D'Agostino, Silvia; Melani, Fabrizio; Zanoni, Bruno; Mulinacci, Nadia; Cecchi, Lorenzo (2024). HS-SPME-GC-MS Analysis of the Volatile Composition of Italian Honey for Its Characterization and Authentication Using the Genetic Algorithm. SEPARATIONS, vol. 11, pp. 0-0, ISSN:2297-8739 DOI Accesso ONLINE all'editore

Crocetti, Letizia; Guerrini, Gabriella; Melani, Fabrizio; Mascia, Maria Paola; Giovannoni, Maria Paola (2024). 3,8-Disubstituted Pyrazolo[1,5-a]quinazoline as GABAA Receptor Modulators: Synthesis, Electrophysiological Assays, and Molecular Modelling Studies. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 25, pp. 1-23, ISSN:1422-0067 DOI

Ugolini, Tommaso; Mattagli, Federico; Melani, Fabrizio; Zanoni, Bruno; Migliorini, Marzia; Trapani, Serena; Giambanelli, Elisa; Parenti, Alessandro; Mulinacci, Nadia; Cecchi, Lorenzo (2024). HS-SPME-GC-MS and Chemometrics for the Quality Control and Clustering of Monovarietal Extra Virgin Olive Oil: A 3-Year Study on Terpenes and Pentene Dimers of Italian Cultivars. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 72, pp. 11124-11139, ISSN:0021-8561 DOI Accesso ONLINE all'editore

Crocetti, Letizia; Khlebnikov, Andrei I.; Guerrini, Gabriella; Schepetkin, Igor A.; Melani, Fabrizio; Giovannoni, Maria Paola; Quinn, Mark T. (2024). Anti-Inflammatory Activity of Pyrazolo[1,5-a]quinazolines. MOLECULES, vol. 29, pp. 1-24, ISSN:1420-3049 DOI

Crocetti, Letizia; Giovannoni, Maria Paola; Vergelli, Claudia; Guerrini, Gabriella; Melani, Fabrizio; Cilibrizzi, Agostino (2024). New quinoline-based PDE4 inhibitors through GSK-256066 fragment-based elaboration. JOURNAL OF MOLECULAR STRUCTURE, vol. 1295, pp. 136719-136734, ISSN:0022-2860 DOI Accesso ONLINE all'editore

Bellumori, Maria; Innocenti, Marzia; Andrenelli, Luisa; Melani, Fabrizio; Cecchi, Lorenzo; Pandino, Gaetano; Mauromicale, Giovanni; La Malfa, Stefano; Mulinacci, Nadia (2023). Composition of discarded Sicilian fruits of Opuntia ficus indica L.: Phenolic content, mineral profile and antioxidant activity in peel, seeds and whole fruit. FOOD CHEMISTRY, vol. 428, pp. 0-0, ISSN:0308-8146 DOI Accesso ONLINE all'editore

Crocetti, Letizia; Guerrini, Gabriella; Melani, Fabrizio; Vergelli, Claudia; Giovannoni, Maria Paola (2023). 4,5-Dihydro-5-Oxo-Pyrazolo[1,5-a]Thieno[2,3-c]Pyrimidine: A Novel Scaffold Containing Thiophene Ring. Chemical Reactivity and In Silico Studies to Predict the Profile to GABAA Receptor Subtype. MOLECULES, vol. 28, pp. 3054-3074, ISSN:1420-3049 DOI

Crocetti, Letizia; Giovannoni, Maria Paola; Guerrini, Gabriella; Lamanna, Silvia; Melani, Fabrizio; Bartolucci, Gian Luca; Pallecchi, Marco; Paoli, Paola; Lippi, Martina; Wang, Junjie; Dahl, Gerhard (2023). Design, Synthesis and Pharmacological Evaluation of New Quinoline-Based Panx-1 Channel Blockers. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 24, pp. 1-23, ISSN:1422-0067 DOI Accesso ONLINE all'editore

Crocetti, Letizia; Guerrini, Gabriella; Giovannoni, Maria Paola; Melani, Fabrizio; Lamanna, Silvia; Di Cesare Mannelli, Lorenzo; Lucarini, Elena; Ghelardini, Carla; Wang, Junjie; Dahl, Gerhard (2022). New Panx-1 Blockers: Synthesis, Biological Evaluation and Molecular Dynamic Studies. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, pp. 4827-4855, ISSN:1422-0067 DOI

Letizia Crocetti, Gabriella Guerrini, Fabrizio Melani, Claudia Vergelli, Maria Paola Giovannoni, Maria Paola Mascia (2022). GABAA receptor modulators with a pyrazolo[1,5-a]quinazoline core: synthesis, molecular modelling studies and electrophysiological assay. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, pp. 13032-13051, ISSN:1422-0067 DOI

Cecchi, Lorenzo; Migliorini, Marzia; Giambanelli, Elisa; Cane, Anna; Zanoni, Bruno; Canuti, Valentina; Mulinacci, Nadia; Melani, Fabrizio (2022). Is the volatile compounds profile a suitable tool for authentication of virgin olive oils (Olea europaea L.) according to cultivars? A study by using HS-SPME-GC-MS and chemometrics. FOOD CONTROL, vol. 139, pp. 0-0, ISSN:0956-7135 DOI Accesso ONLINE all'editore

Catarzi, Daniela; Varano, Flavia; Vigiani, Erica; Calenda, Sara; Melani, Fabrizio; Varani, Katia; Vincenzi, Fabrizio; Pasquini, Silvia; Mennini, Natascia; Nerli, Giulia; Dal Ben, Diego; Volpini, Rosaria; Colotta, Vittoria (2022). 4-Heteroaryl Substituted Amino-3,5-Dicyanopyridines as New Adenosine Receptor Ligands: Novel Insights on Structure-Activity Relationships and Perspectives. PHARMACEUTICALS, vol. 15, pp. 0-0, ISSN:1424-8247 DOI

Cirri M.; Mennini N.; Nerli G.; Rubia J.; Casalone E.; Melani F.; Maestrelli F.; Mura P. (2021). Combined use of cyclodextrins and amino acids for the development of cefixime oral solutions for pediatric use. PHARMACEUTICS, vol. 13, pp. 0-0, ISSN:1999-4923 DOI

Crocetti, Letizia; Guerrini, Gabriella; Cantini, Niccolò; Vergelli, Claudia; Melani, Fabrizio; Mascia, Maria Paola; Giovannoni, Maria Paola (2021). 'Proximity frequencies' a new parameter to evaluate the profile of GABAAR modulators. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 34, pp. 127755-127762, ISSN:0960-894X DOI

Cecchi L.; Migliorini M.; Giambanelli E.; Rossetti A.; Cane A.; Mulinacci N.; Melani F. (2020). Authentication of the geographical origin of virgin olive oils from the main worldwide producing countries: A new combination of HS-SPME-GC-MS analysis of volatile compounds and chemometrics applied to 1217 samples. FOOD CONTROL, vol. 112, pp. 0-0, ISSN:0956-7135 DOI Accesso ONLINE all'editore

Diletta Balli , Maria Bellumori , Laura Pucci , Morena Gabriele , Vincenzo Longo , Paolo Paoli , Fabrizio Melani , Nadia Mulinacci , Marzia Innocenti (2020). Does Fermentation Really Increase the Phenolic Content in Cereals? A Study on Millet. FOODS, pp. 0-0, ISSN:2304-8158 DOI

Gabriella Guerrini, Letizia Crocetti, Simona Daniele, Antonella Iacovone, Niccolò Cantini,Claudia Martini, Fabrizio Melani, Claudia Vergelli, Maria Paola Giovannoni, (2019). New 3,6-disubstituted pyrazolo[1,5-a]quinazolines as ligands to GABAA receptor subtype. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 56, pp. 1571-1580, ISSN:1943-5193 DOI

Giulia Lori, Lorenzo Cecchi, Nadia Mulinacci, Fabrizio.Melani, Anna Caselli, Paolo Cirri, Luigia Pazzagli, Simone Luti, Lorenzo Mazzoli, Paolo Paoli (2019). Honey extracts inhibit PTP1B, upregulate insulin receptor expression, and enhance glucose uptake in human HepG2 cells. BIOMÉDECINE & PHARMACOTHÉRAPIE, vol. 113, pp. 0-0, ISSN:0753-3322 DOI Accesso ONLINE all'editore

Cecchi, Lorenzo; Migliorini, Marzia; Giambanelli, Elisa; Rossetti, Adolfo; Cane, Anna; Melani, Fabrizio; Mulinacci, Nadia (2019). Headspace Solid-Phase Microextraction-Gas Chromatography-Mass Spectrometry Quantification of the Volatile Profile of More than 1200 Virgin Olive Oils for Supporting the Panel Test in Their Classification: Comparison of Different Chemometric Approaches. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 67, pp. 9112-9120, ISSN:0021-8561 DOI Accesso ONLINE all'editore

Lorenzo Cecchi, Marzia Migliorini, Fabrizio Melani, Elisa Giambanelli, Luca Calamai, Adolfo Rossetti, Anna Cane, Nadia Mulinacci (2019). Quantification of volatile fraction by HS-SPME-GC-MS and sensory evaluation of more than 1200 Virgin Olive Oil samples to support Panel Test in Virgin Olive Oil classification. In: XX EuroFoodChem Congress, Porto, 17-19 June 2019, Sociedade Portuguesa de Química, pp. 29-29, ISBN:978-989-8124-26-5 Accesso ONLINE all'editore

Lorenzo Cecchi, Luca Calamai, Fabrizio Melani, Nadia Mulinacci (2019). Usefulness of HS-SPME-GC-MS quantification of volatile compounds for quality control of virgin olive oil. In: 6 MS Food Day, Camerino, 25-27 Settembre 2019, Società Chimica Italiana - Divisione Spettrometria di Massa, pp. 0-0, ISBN:978-889-0738-88-3

Caprini, Claudia; Pasquini, Benedetta; Melani, Fabrizio; DEL BUBBA, Massimo; Giuffrida, A.; Calleri, E.; Orlandini, Serena; Furlanetto, Sandra (2018). Exploring the intermolecular interactions acting in solvent-modified MEKC by Molecular Dynamics and NMR: The effect of n-butanol on the separation of diclofenac and its impurities. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 149, pp. 249-257, ISSN:0731-7085 DOI

Cecchi, Lorenzo; Innocenti, Marzia; Melani, Fabrizio; Migliorini, Marzia; Conte, Lanfranco; Mulinacci, Nadia (2017). New isobaric lignans from Refined Olive Oils as quality markers for Virgin Olive Oils. FOOD CHEMISTRY, vol. 219, pp. 148-157, ISSN:0308-8146 DOI Accesso ONLINE all'editore

Pasquini, B.; Orlandini, S.; Melani, F.; Caprini, C.; Del Bubba, M.; Furlanetto, S. (2017). Enantioseparation and impurity determination of cinacalcet using solvent modified capillary zone electrophoresis and Quality by Design: study of the complexation with cyclodextrins by molecular modeling and NMR. In: Giornate di chimica analitica in memoria del Prof. Francesco Dondi-Recenti sviluppi in Scienze delle Separazioni e Bioanalitica, Ferrara, 10-11 Luglio 2017, Giornate di chimica analitica in memoria del Prof. Francesco Dondi-Recenti sviluppi in Scienze delle Separazioni e Bioanalitica, pp. 40-40.

Pasquini, B.; Melani, F.; Caprini, C.; Del Bubba, M.; Pinzauti, S.; Orlandini, S.; Furlanetto, S. (2017). Combined approach using capillary electrophoresis, NMR and molecular modeling for ambrisentan related substances analysis: Investigation of intermolecular affinities, complexation and separation mechanism. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 144, pp. 220-229, ISSN:0731-7085 DOI

Khatib, Mohamad; Pieraccini, Giuseppe; Innocenti, Marzia; Melani, Fabrizio; Mulinacci, Nadia (2016). An insight on the alkaloid content of Capparis spinosa L. root by HPLC-DAD-MS, MS/MS and 1H qNMR. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 123, pp. 53-62, ISSN:0731-7085 DOI Accesso ONLINE all'editore

Caprini, Claudia; Pasquini, Benedetta; Orlandini, Serena; Melani, Fabrizio; Furlanetto, Sandra (2016). Impurity profiling by capillary electrophoresis: definition of the design space within quality by design approach and investigation of separation mechanism and selectivity. In: Merck Young Chemists Symposium, Rimini, Italy, 27-27 Ottobre 2016, Società Chimica Italiana, pp. 119-119, ISBN:9788886208925

M. Ramazzotti; F. Melani; L. Marchi; N. Mulinacci; S. Gestri; B. Tiribilli; D. Degl'Innocenti (2016). Mechanisms for the inhibition of amyloid aggregation by small ligands. BIOSCIENCE REPORTS, vol. 36, pp. e00385-e00385, ISSN:0144-8463 DOI Accesso ONLINE all'editore

Furlanetto, S.; Orlandini, S.; Pasquini, B.; Melani, F.; Caprini, C.; Innocenti, M.; Del Bubba, M. (2016). Combination of capillary electrophoresis, Quality by Design, NMR and molecular modeling for impurity profiling: definition of the design space and investigation of intermolecular affinities, complexation and separation mechanisms. In: XXVI Congresso della Divisione di Chimica Analitica della Società Chimica Italiana, Giardini Naxos (ME), Italy, 18-22 Settembre 2016, Silvio Sammartano, Concetta De Stefano, Luigi Mondello, pp. 145-145, ISBN:978-88-86208-91-8

Gabriella Guerrini; Giovanna Ciciani; Samuele Ciattini; Letizia Crocetti; Simona Daniele; Claudia Martini; Fabrizio Melani; Claudia Vergelli; Maria Paola Giovannoni (2016). Pyrazolo[1,5-a]quinazoline scaffold as 5-deaza analogue of pyrazolo[5,1-c][1,2,4]benzotriazine system: synthesis of new derivatives, biological activity on GABAA receptor subtype and molecular dynamic study. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 31, pp. 195-204, ISSN:1475-6366 DOI

Furlanetto, S.; Melani, F.; Pasquini, B.; Orlandini, S.; Caprini, C. (2016). Quality by Design, NMR and Molecular Modeling for the investigation of intermolecular affinities and separation mechanisms in capillary electrophoretic methods for assaying drugs and their impurities. In: 27th International Symposium on Pharmaceutical and Biomedical Analysis, Guangzhou, Cina, 13-16 Novembre 2016, 27th International Symposium on Pharmaceutical and Biomedical Analysis, pp. 112-112.

A. Pratesi; M. Ginanneschi; F. Melani; M. Chinol; A. Carollo; G. Paganelli; M. Lumini; M. Bartoli; M. Frediani; L. Rosi; G. Petrucci; L. Messori; and A.M. Papini. (2015). Design and Solid Phase Synthesis of New DOTA Conjugated (+)-Biotin Dimers Planned to Develop Molecular Weight-Tuned Avidin Oligomers. ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 13, pp. 3988-4001, ISSN:1477-0520 DOI Accesso ONLINE all'editore

Guandalini, Luca; Martino, Maria Vittoria; Di Cesare Mannelli, Lorenzo; Bartolucci, Gianluca; Melani, Fabrizio; Malik, Ruchi; Dei, Silvia; Floriddia, Elisa; Manetti, Dina; Orlandi, Francesca; Teodori, Elisabetta; Ghelardini, Carla; Romanelli, Maria Novella (2015). Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the cognition-enhancer DM235. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 25, pp. 1700-1704, ISSN:0960-894X DOI

Caprini, C.; Melani, F.; Fiordalisi, V.; Orlandini, S.; Pasquini, B.; Gotti, R.; Furlanetto, S. (2015). Effect of cosurfactant on separation selectivity in solvent-modified MEKC: the diclofenac case. In: XXV Congresso della Divisione di Chimica Analitica della Società Chimica Italiana, Trieste, 13-17 Settembre 2015, Antonella Rossi, Gianpiero Adami, pp. 239-239, ISBN:978-88-907670-2-9

Melani, Fabrizio; Pasquini, Benedetta; Caprini, Claudia; Gotti, Roberto; Orlandini, Serena; Furlanetto, Sandra (2015). Combination of capillary electrophoresis, molecular modeling and NMR to study the enantioselective complexation of sulpiride with double cyclodextrin systems. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 114, pp. 265-271, ISSN:0731-7085 DOI

S. Pascarella, F. Melani, L Giovannelli, A.M. Papini, P. Rovero (2014). Molecular modelling assisted design of a TASP mimicking SERPINH1 chaperone function in collagen biosynthesis. In: Emilia Naydenova, Tamara Papainova, and Dancho Danalev. Peptides 2014, pp. 152-153, Sofia: European Peptide Society, ISBN:978-619-90427-2-4. Accesso ONLINE all'editore

S. Pascarella, F. Melani, L. Giovannelli, A. M. Papini, P. Rovero (2014). MIMICKING SERIN PROTEASE INHIBITOR H1 CHAPERONE FUNCTION IN COLLAGEN BIOSYTNHETIC PATHWAY VIA THE TEMPLATE ASSEMBLED SYNTHETIC PROTEIN APPROACH. JOURNAL OF PEPTIDE SCIENCE, vol. 20, pp. 173-174, ISSN:1075-2617

Benedetta Pasquini; Fabrizio Melani; Serena Orlandini; Sergio Pinzauti; Sandra Furlanetto (2014). Evaluation of the inclusion complex formation of levosulpiride and cyclodextrins by capillary electrophoresis, molecular modeling and NMR. In: XXV Congresso Nazionale della Società Chimica Italiana, Arcavacata di Rende (CS), 7-12 Settembre 2014, ---, pp. 229-229.

Anna Rita Santamaria; Marzia Innocenti; Nadia Mulinacci;Fabrizio Melani;Alessio Valletta; Ilaria Sciandra; Gabriella Pasqua (2012). Enhancement of Viniferin Production in Vitis vinifera L. cv. Alphonse Lavalle'e Cell Suspensions by Low-Energy Ultrasound Alone and in Combination with Methyl Jasmonate. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 60, pp. 11135-11142, ISSN:0021-8561 DOI

F.Melani; I.Giannini; B.Pasquini; S.Orlandini; S.Pinzauti; S.Furlanetto (2011). Evaluation of the separation mechanism of electrokinetic chromatography with a microemulsion and cyclodextrins using NMR and molecular modeling. ELECTROPHORESIS, vol. 32, pp. 3062-3069, ISSN:0173-0835

G. Guerrini; G. Ciciani; F. Bruni; S. Selleri; F. Melani; S. Daniele; C. Martini; A. Costanzo (2011). New 3-, 8-disubstituted pyrazolo[5,1-c][1,2,4]benzotriazines useful for studying the interaction with the HBp-3 area (hydrogen bond point area) in the benzodiazepine site on the gamma-aminobutyric acid type A (GABAA) receptor. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, pp. 3074-3085, ISSN:1464-3391 DOI

Jug, Mario; Mennini, Natascia; Melani, Fabrizio; Maestrelli, Francesca; Mura, PAOLA ANGELA (2010). Phase solubility, 1H NMR and molecular modelling studies of bupivacaine hydrochloride complexation with different cyclodextrin derivates. CHEMICAL PHYSICS LETTERS, vol. 500, pp. 347-354, ISSN:0009-2614 DOI

G. Guerrini; G. Ciciani; F. Bruni; S. Selleri; C. Guarino; F. Melani; M. Montali; S. Daniele; C. Martini; C. Ghelardini; M. Norcini; S. Ciattini; A. Costanzo (2010). New fluoro derivatives of the pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide system: evaluation of fluorine binding properties in the benzodiazepine site on gamma-aminobutyrric acid type A (GABAA) receptor. Design, synthesis, biological evaluation, and molecular modeling investigation.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, pp. 7532-7548, ISSN:1520-4804 DOI

C. Bazzicalupi; M. Chioccioli; C. Sissi; E. Porcù; C. Bonaccini; C. Pivetta; A. Bencini; C. Giorgi; B. Valtancoli; F. Melani; P. Gratteri (2010). Modeling and Biological Investigations of an Unusual Behavior of Novel Synthesized Acridine- Based Polyamine Ligands in the Binding of Double Helix and G-Quadruplex DNA. CHEMMEDCHEM, vol. 5, pp. 1995-2005, ISSN:1860-7179 DOI Accesso ONLINE all'editore

S.Furlanetto; F.Melani; I.Giannini; S.Orlandini; B.Pasquini; S.Pinzauti (2010). Evaluation of the separation mechanism in a dual-CD microemulsion system for capillary electrophoresis analysis. In: XXII Convegno Nazionale della Divisione di Chimica Analitica della Società Chimica Italiana, Como, 12-16 settembre 2010, XXII Convegno Nazionale della Divisione di Chimica Analitica della Società Chimica Italiana, pp. P22b-P22b.

S. Furlanetto; F. Melani; I. Giannini; S. Orlandini; B. Pasquini; S. Pinzauti (2010). Insights into EKC with microemulsions and cyclodextrins by means of NMR and molecular modeling: clemastine case study. In: Drug Analysis 2010, Antwerp, Belgio, 21-24 settembre 2010, Drug Analysis 2010, pp. 173-173.

G. Gabrielli; F. Melani; S. Bernasconi; C. Lunghi; B. Richichi; P. Rollin; C. Venturi; C. Nativi (2009). Stereoselective synthesis of 1,3-disaccharides through Diels-Alder reactions: Part 2: convenient protecting groups for heterodienes and conformational evaluations. JOURNAL OF CARBOHYDRATE CHEMISTRY, vol. 28, pp. 124-141, ISSN:0732-8303 DOI Accesso ONLINE all'editore

G. Guerrini; G. Ciciani; G. Cambi; F. Bruni; S.Selleri; C. Guarino; F. Melani; M. Montali; C: Martini; C. Ghelardini; M. Norcini; A. Costanzo (2009). Synthesis, in vivo evaluation, and molecular modeling studies of new pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide derivatives. Identification of a bifunctional hydrogen bond area related to the inverse-agonism. JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, pp. 4668-4682, ISSN:0022-2623 DOI

M. SALVATI; F. M. CORDERO; F. PISANESCHI; F. MELANI; P. GRATTERI; N. CINI; A. BOTTONCETTI; A. BRANDI (2008). Synthesis, SAR and in Vitro Evaluation of New Cyclic Arg-Gly-Asp Pseudopentapeptides Containing a s-cis Peptide Bond as Integrin alpha-v-beta3 and alpha-v-beta5 Ligands.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, pp. 4262-4271, ISSN:0968-0896 DOI

G. Guerrini; G. Ciciani; G. Cambi; F. Bruni; S. Selleri; F. Melani; M. Montali; C. Martini; C. Ghelardini; M. Norcini; A. Costanzo (2008). Novel 3-aroylpyrazolo[5,1-c][1,2,4] benzotriazines 5-oxides 8-substituted, ligands at GABAA/benzodiazepine receptor complex: synthesis, pharmacological and molecular modelling studies.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, pp. 4471-4489, ISSN:1464-3391 DOI

J. Sgrignani; C. Bonaccini; F. Melani; D. Catarzi; P. Gratteri (2006). Docking and 3D-QSAR analysis on i-GluR2 receptor. In: XXII Congresso Nazionale della Società Chimica Italiana., Firenze, 10-15 settembre 2006, d, pp. 188-188.

S. SELLERI; P. GRATTERI; C. COSTAGLI; C. BONACCINI; A. COSTANZO; F. MELANI; G. GUERRINI; G. CICIANI; B. COSTA; C. MARTINI; F. BRUNI; F. SPINETTI (2005). Insight into 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl acetamides as Peripheral Benzodiazepine Receptor Ligands: synthesis, biological evaluation and 3D-QSAR investigation.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 13, pp. 4821-4834, ISSN:0968-0896 DOI Accesso ONLINE all'editore

P. Gratteri; C. Bonaccini; F. Melani (2005). Searching for a reliable orientation of ligands in their binding site: Glide versus FIGO in the case study of PDE4 inhibitorsJ. Med. Chem., , 48(5), 1657-65. JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, pp. 1657-1665, ISSN:0022-2623 DOI Accesso ONLINE all'editore

P. GRATTERI; M. ROMANELLI; G. CRUCIANI; C. BONACCINI; F. MELANI (2004). GRIND-derived pharmacophore model for a series of α-tropanyl derivative ligands of the sigma-2 receptor. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, vol. 18, pp. 361-374, ISSN:0920-654X DOI Accesso ONLINE all'editore

F. Melani; P. Mura; M. Adamo; F. Maestrelli; P. Gratteri; C. Bonaccini (2003). New docking CFF91 parameters specific for cyclodextrin inclusion complexes. CHEMICAL PHYSICS LETTERS, vol. 370, pp. 280-292, ISSN:0009-2614 DOI

F. Melani; P. Gratteri; M. Adamo; C. Bonaccini (2003). Field Interaction and Geometrical Overlap (FIGO): a new Simplex/experimental design-based computational procedure for superposing small ligand molecules. J. Med. Chem., 46(8), 1359-1371 (2003).. JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, pp. 1359-1371, ISSN:0022-2623 DOI

E. Silvestrini; N. Mulinacci; C. Giaccherini; M. Innocenti; F. Melani (2002). Descrizione topologica del recettore del gusto amaro attraverso attraverso tecniche di molecular modelling e Panel test. In: 5° CISETA, pp. 1196-1202.

M.T.FAUCCI;F.MELANI;P.MURA (2002). Computer-aided molecular modeling techniques for predicting the stability of drug-cyclodextrin inclusion complexes in acqueous solutions.. CHEMICAL PHYSICS LETTERS, vol. 358, pp. 383-390, ISSN:0009-2614

N. Mulinacci; E. Silvestrini; C. Giaccherini; M. Innocenti; F.F. Vincieri; M. Adamo; F. Melani (2002). Molecular modeling and biological tests for a topologic description of bitter taste receptor. In: 4th World Meeting on Pharmacetics Biopharmaceutics Pharmaceutical technology, Firenze, 8-11 Aprile, pp. 1105-1106.

P. GRATTERI; C. BONACCINI; F. MELANI; M. ADAMO; V. DAL PIAZ; G. CRUCIANI (2002). GRID-DOCKING STUDY ON LIGANDS ACTING AS INHIBITORS OF THE HUMAN PHOSPHODIESTERASE 4. In: XVIIth International Symposium on Medicinal Chemistry, Barcelona, Spain, 1-5 September, 2002, vol. SUPPL A, pp. 139-139.

F. MELANI; P. GRATTERI; M. ADAMO; C. BONACCINI (2001). FILO (Field Interaction Ligand Optimization): a simplex strategy for searching the optimal ligand interaction field in drug design.. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, vol. 15, pp. 57-66, ISSN:0920-654X Accesso ONLINE all'editore

F. Melani; P. Gratteri; C. Bonaccini; M. Adamo; V. Colotta (2000). Field-Interaction-Ligand-Optimization ( F.I.L.O.) in the development of 3D-QSAR models for the rational design of selective adenosine receptor ligands. In: XVI International Symposium on Medicinal Chemistry, Bologna, 18-22 Settembre 2000, d, pp. 138-138.

F. MELANI; P. MURA; M. FAUCCI (2000). 1H-NMR and molecular modelling techniques for the investigation of the inclusion complex of econazole with a-cyclodextrin in the presence of malic acid. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 23, pp. 25-31, ISSN:0731-7085

P. GRATTERI; G. CRUCIANI; S. SCAPECCHI; M. ROMANELLI; F. MELANI (2000). 3D-QSAR, GRID DESCRIPTORS AND CHEMOMETRIC TOOLS IN THE DEVELOPMENT OF SELECTIVE ANTAGONIST OF MUSCARINIC RECEPTOR.. In: K. GUNDERTOFTE AND F.S. JORGENSEN (EDS.). MOLECULAR MODELING AND PREDICTION OF BIOACTIVITY, pp. 334-335, New York: Kluwer Academic/Plenum Publisher, ISBN:9780306462177.

G. BETTINETTI; P. MURA; F. MELANI; M. SORRENTI; A. NEGRI; M. SETTI (1999). Interaction of naproxen and alpha-cyclodextrin and its noncyclic analog maltohexaose. PHARMACEUTICAL RESEARCH, vol. 16, pp. 689-694, ISSN:0724-8741

F. MELANI; P. MURA; B. TRACUZZI (1998). PHASE-SOLUBILITY ANALYSIS AND MOLECULAR MODELING IN THE STUDY OF NAPROXEN-CYCLODEXTRIN INTERACTION.. In: NINTH INTERNATIONAL SYMPOSIUM ON CYCLODEXTRIN, SANTIAGO DE COMPOSTELA, 31/05/1998 - 3/06/1998, Springer Science, pp. 379-382.

V. COLOTTA; D. CATARZI; F. VARANO; F. MELANI; G.FILACCHIONI; L. CECCHI; L. TRINCAVELLI; C. MARTINI; A. LUCACCHINI (1998). Synthesis and A1 and A2A binding activity of some pyrano[2,3-c]pyrazol-4-ones.. IL FARMACO, vol. 53, pp. 189-196, ISSN:0014-827X

F. MELANI; N. MULINACCI; A. ROMANI; G. MAZZI; F. VINCIERI (1998). MOLECULAR DYNAMIC SIMULATION AND DOCKING ENERGY TO FORECAST THE STABILITY OF BCYD-COMPLEX IN WATER SOLUTION.. INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 166, pp. 145-155, ISSN:0378-5173

G. BETTINETTI; P. MURA; F. MELANI; F. GIORDANO; M. RILLOSI (1996). INTERACTIONS BETWEEN NAPROXEN AND MALTOHEPTAOSE, THJE NON-CYCLIC ANALOG OF BETA-CYCLODEXTRIN. JOURNAL OF INCLUSION PHENOMENA AND MOLECULAR RECOGNITION IN CHEMISTRY, vol. 25, pp. 327-338, ISSN:0923-0750

V. COLOTTA; D. CATARZI; F. VARANO; F. MELANI; G.FILACCHIONI; L. CECCHI; A. GALLI; C. COSTAGLI (1996). Benzodiazepine binding activity of some tricyclic heteroarometic systems to define the hydrogen bonding strength of the proton donors of the receptor site.. IL FARMACO, vol. 51, pp. 223-229, ISSN:0014-827X

N. MULINACCI; F. MELANI; F. VINCIERI; G. MAZZI; A. ROMANI (1996). 1H-NMR NOE and molecular modelling to characterize thymol and carvacrol β-cyclodextrin complexes. INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 128 (1-2), pp. 81-88, ISSN:0378-5173

F. MELANI; G. BETTINETTI; P. MURA; A. MANDERIOLI (1995). INTERACTION OF NAPROXEN WITH ALPHA, BETA AND GAMMA HYDROXYPROPYL CYCLODEXTRINS IN SOLUTION AND IN THE SOLID STATE. JOURNAL OF INCLUSION PHENOMENA AND MOLECULAR RECOGNITION IN CHEMISTRY, vol. 22, pp. 131-143, ISSN:0923-0750

P. MURA; G. BETTINETTI; F. MELANI; A. MANDERIOLI (1995). LNTERACTION BETWEEN NAPROXEN AND CHEMICALLY MODIFIED ß-CICIODEXTRINS IN THE LIQUID AND SOLID STATE. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 3, pp. 347-355, ISSN:0928-0987

D. CATARZI; L. CECCHI; V. COLOTTA; F. MELANI; G.FILACCHIONI; C. MARTINI; L.GIUSTI; A. LUCACCHINI. (1994). STRUCTURE-ACTIVITY RELATIONSHIPS OF 1,2,4-TRIAZOLO[1,5-A]QUINOXALINES AND THEIR 1-DEAZA ANALOGS IMIDAZO[1,2-A]QUINOXALINES AT THE BENZODIAZEPINE RECEPTOR.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 37, pp. 2846-2850, ISSN:0022-2623

F. MELANI; P. MURA; G. BETTINETTI; F. GIORDANO (1994). PHASE-SOLUBILITY ANAIYSIS AND MOLECULAR MODELLING IN THE STUDY OF INTERACTION OF NAPROXEN WITH HYDROXYETHYL-ß-CYCIODEXTRINS. In: 7th INTERNATIONAL CYCLODEXTRÍN SYMPOSIUM, Tokyo, 25-28 aprile 1994, Tetsuo Osa, pp. 66-66.

D.CATARZI; L. CECCHI; V.COLOTTA; G.CONTI; F.MELANI; G. FILACCHIONI; C. MARTINI; L. GIUSTI; A.LUCACCHINI (1993). REACTION OF 1-AMINOPHTHALAZINES WITH A-HALOCARBONYL COMPOUNDS: IMIDAZO-2,1-A]PHTHALAZINES AND THEIR BENZODIAZEPINE RECEPTOR ACTIVITIES.. IL FARMACO, vol. 48, pp. 447-457, ISSN:0014-827X

C.COLOTTA; L. CECCHI; D.CATARZI; F.MELANI; G. FILACCHIONI; C. MARTINI; P.TACCHI; A. LUCACCHINI; (1993). NOVEL ADENOSINE RECEPTOR LIGANDS: 1,3-DISUBSTITUTED[1]BENZOPYRANO[2,3-C]PYRAZOL-4-ONES. SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS.. RECEPTORS & CHANNELS, vol. 1, pp. 111-119, ISSN:1060-6823

D.CATARZI; L. CECCHI; V.COLOTTA; F.MELANI; G. FILACCHIONI; C. MARTINI; L.GIUSTI; A. LUCACCHINI (1993). TRICYCLIC HETEROAROMATIC SYSTEMS 1,2,4-TRIAZOLO[1,5-A]QUINOXALINES: SYNTHESIS AND BENZODIAZEPINE RECEPTOR ACTIVITY.. IL FARMACO, vol. 48, pp. 1065-1078, ISSN:0014-827X

N. MULINACCI; F. MELANI; G. MAZZI; F. VINCIERI (1993). MOLECULAR MODELING AND NMR NOE EXPERIMENTS: COMPLEMENTARY TOOLS FOR THE INVESTIGATION OF COMPLEX IBUPROXAM-B-CYCLODEXTRIN TOPOLOGY. INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 90, pp. 35-41, ISSN:0378-5173

V. Colotta; D. Catarzi; L. Cecchi; Gabriele Conti; F. Melani; G. Filacchioni; A. Lucacchini C. Martini (1992). Structure-activity relationships on rigid benzodiazepine receptor ligands. In: XVII Congresso Nazionale della Divisione di Chimica Farmaceutica della SCI, Genova, 25-30 Ottobre 1992, d, pp. 54-55.

V.Colotta; L.Cecchi; F.Melani; D.Catarzi; G.Filacchioni; C.Martini; G.Giannaccini; M.Tonelli; A.Lucacchini (1992). Tricyclic heteroaromatic systems. Synthesis and benzodiazepine binding activity of 1-substituted-3-methyl- and 3-phenylpyrazolo[4,5-c]quinolin-4-ones.. DRUG DESIGN AND DISCOVERY, vol. 8, pp. 325-339, ISSN:1055-9612

L. Cecchi; V. Colotta; D. Catarzi; F. Melani; G. Filacchioni; C. Martini; P. Tacchi; A. Lucacchini (1992). Synthesis and structure-activity relationships on 1,3-disubstituted [1]benzopyrano[2,3-c]pyrazol-4-ones, a new class of adenosine receptor antagonists. In: XXII International Symposium on Medicinal Chemistry, Basel, Switzerland, 13-17 September 1992, d, pp. 284-284.

F.MELANI; L. CECCHI; V. COLOTTA; D. CATARZI; G.FILACCHIONI (1992). TRICYCLIC HETEROAROMATIC SYSTEMS. 5H-1,2,4-TRIAZOLO[5,1-C][1,4]BENZODIAZEPINE.. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 29, pp. 819-823, ISSN:0022-152X

D. CATARZI; L. CECCHI; V. COLOTTA; G.FILACCHIONI; F. MELANI (1992). TRICYCLIC HETEROAROMATIC SYSTEMS. 1,2,4-TRIAZOLO[1,5-A]QUINOXALINE.. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 29, pp. 1161-1163, ISSN:0022-152X

V.Colotta; L.Cecchi; D.Catarzi; F.Melani; G.Filacchioni; C.Martini; P.Tacchi; A.Lucacchini (1992). 1-(3-Aminophenyl)-3-methyl[1]benzopyrano[2,3-c]pyrazol-4-one: a new selective A2 adenosine receptor antagonist.. PHARMACEUTICAL AND PHARMACOLOGICAL LETTERS, vol. 2, pp. 74-76, ISSN:0939-9488

D. Catarzi; L. Cecchi; V. Colotta; F. Melani; G. Filacchioni; P. Tacchi; M. Tonelli; C. Martini. (1991). Tricyclic heteroaromatic systems. Synthesis and adenosine receptor binding evaluation of some pyrazolo-quinoline and [1]benzopyrano-pyrazole derivatives. INTERNATIONAL JOURNAL OF PURINE & PYRIMIDINE RESEARCH, vol. 2, pp. 113-121, ISSN:1120-6918

V. COLOTTA; L. CECCHI; F. MELANI; G. FILACCHIONI; C. MARTINI; S. GELLI; A. LUCACCHINI (1991). TRICYCLIC HETEROAROMATIC SYSTEMS: [1]BENZOPYRANOPYRAZOL-4-ONES AS BENZODIAZEPINE RECEPTOR LIGANDS.. JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 80, pp. 276-279, ISSN:0022-3549

V.COLOTTA; L. CECCHI; F.MELANI; G. FILACCHIONI; C. MARTINI; S.GELLI; A. LUCACCHINI (1991). TRICYCLIC HETEROAROMATIC SYSTEMS. SYNTHESIS OF 1,3 AND 1,2 DISUBSTITUTED [1]BENZOPYRANO[4,3-B]PYRROL-4-ONES AND STRUCTURE-ACTIVITY RELATIONSHIPS AS BENZODIAZEPINE RECEPTOR LIGANDS.. IL FARMACO, vol. 46, pp. 1139-1154, ISSN:0014-827X

F. Melani; L. Cecchi; V. Colotta; D. Catarzi; G. Filacchioni. (1991). Qualitative requirements for rigid benzodiazepine receptor ligands. In: X Congresso Nazionale della Divisione di Chimica Farmaceutica della SCI, Siena, 16-20 settembre 1991, d, pp. 44-44.

R. MONNANNI; F. MELANI; P. MURA; G. BETTINETTI; F. GIORDANO (1991). CARBON-13 NMR STUDY OF NAPROXEN WITH CYCLODEXTRINS IN SOLUTION.. JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 80, pp. 1162-1170, ISSN:0022-3549

V. COLOTTA; L. CECCHI; F. MELANI; G. FILACCHIONI; C. MARTINI; G. GIANNACCINI; A. LUCACCHINI (1990). TRICYCLIC HETEROAROMATIC SYSTEMS. [1]BENZOPYRANOPYRROL-4-ONES AND [1]BENZOPYRANO-1,2,3-TRIAZOL-4-ONES AS BENZODIAZEPINE RECEPTOR LIGANDS. SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, pp. 2646-2651, ISSN:0022-2623

G.Bettinetti; P.Mura; F.Melani; F.Giordano (1990). (S)-(+)-6-Methoxy-α-methyl-2-naphtaleneacetic acid and β-cyclodextrin derivatives: inclusion in aqueous media and solid phase interaction. In: 5th International Symposium on Cyclodextrins, Parigi, 28-30/03/1990, Dominique Duchene, Université de Paris-Sud, France, pp. 239-242.

F. MELANI; L. CECCHI; V. COLOTTA; G. FILACCHIONI (1989). TRICYCLIC HETEROAROMATIC SYSTEMS. 5H-1,2,3-TRIAZOLO[5,1-C][1,4]BENZODIAZEPINE.. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 26, pp. 1605-1609, ISSN:0022-152X

F. Melani; L. Cecchi; V. Colotta; G. Filacchioni; C. Martini; G. Giannaccini; A. Lucacchini (1989). Momento dipolare e aree idrofobiche in relazione con l'affinità e l'effetto biologico di ligandi del recettore benzodiazepinico. In: 1° Congresso congiunto ispano-italiano di Chimica Farmaceutica, Granada, Spagna, Settembre 1989, d, pp. 461-461.

V. COLOTTA; L. CECCHI; F. MELANI; G. PALAZZINO; G. FILACCHIONI; C. MARTINI; G. GIANNACCINI; A. LUCACCHINI (1989). TRICYCLIC HETEROAROMATIC SYSTEMS: SYNTHESIS, [3H]FLUNITRAZEPAM BRAIN MEMBRANE BINDING INHIBITION, AND STRUCTURE-ACTIVITY RELATIONSHIPS OF 2,3-DIHYDRO-2-ARYL-4-R-[1]BENZOPYRANO[4,3-C]PYRAZOL-3-ONES.. JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 78, pp. 239-242, ISSN:0022-3549

G. PALAZZINO; L. CECCHI; V. COLOTTA; F. MELANI; G. FILACCHIONI (1989). TRICYCLIC HETEROAROMATIC SYSTEMS. 1,2,3,4-TETRAHYDROPYRAZOLO[4,3-C][1]BENZAZEPIN-1-ONES AS POTENTIAL ANTITUMOR AGENTS.. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 26, pp. 71-75, ISSN:0022-152X

F. MELANI; L. CECCHI; V. COLOTTA; G. FILACCHIONI; C. MARTINI; G. GIANNACCINI; A. LUCACCHINI (1989). DIPYRAZOLO[5,4-B:3',4'-D]PYRIDINES. SYNTHESIS, INHIBITION OF BENZODIAZEPINE RECEPTOR BINDING AND STRUCTURE-ACTIVITY RELATIONSHIPS.. IL FARMACO, vol. 44, pp. 585-594, ISSN:0014-827X

L. CECCHI; V. COLOTTA; F. MELANI; G. PALAZZINO; G. FILACCHIONI; C. MARTINI; G. GIANNACCINI; A. LUCACCHINI (1989). SYNTHESIS OF 1,5-DIARYL-3-METHYL-1H-PYRAZOLO[4,5-C]ISOQUINOLINES AND STUDIES OF BINDING TO SPECIFIC PERIPHERAL BENZODIAZEPINE BINDING SITES.. JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 78, pp. 437-442, ISSN:0022-3549

V. COLOTTA; L. CECCHI; G. FILACCHIONI; F. MELANI; G. PALAZZINO; C. MARTINI; G. GIANNACCINI; A. LUCACCHINI (1988). SYNTHESIS, BINDING STUDIES, AND STRUCTURE ACTIVITY RELATIONSHIPS OF 1-ARYL- AND 2-ARYL[1]BENZOPYRANOPYRAZOL-4-ONES, CENTRAL BENZODIAZEPINE RECEPTOR LIGANDS.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 31, pp. 1-3, ISSN:0022-2623

F. MELANI; L. CECCHI; V. COLOTTA; G. PALAZZINO; G. FILACCHIONI (1988). TRICYCLIC HETEROCYCLIC SYSTEMS: PYRAZOLO[5',4':4,5]- AND PYRAZOLO[3',4':4,5]PYRANO[2,3-B]PYRIDINE DERIVATIVES.. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 25, pp. 1367-1371, ISSN:0022-152X

V. COLOTTA; L. CECCHI; F. MELANI; G. PALAZZINO; G. FILACCHIONI (1987). THE CORRECT SYNTHESIS OF 2,3-DIHYDRO-2-ARYL-4-R-[1]BENZOPYRANO[4,3-C]PYRAZOLE-3-ONES.. TETRAHEDRON LETTERS, vol. 28, pp. 5165-5168, ISSN:0040-4039

V. Colotta; L. Cecchi; G. Filacchioni; F. Melani; G. Palazzino. (1987). [1]Benzopyrano-pyrazole-3-ones. Correct and generalized synthetic metod. In: French-italian joint meeting on Medicinal Chemistry, Pisa, Settembre 1987, d, pp. 105-105.

L. CECCHI; V. COLOTTA; G.FILACCHIONI; F. MELANI; G. PALAZZINO; A. GALLI (1987). SYNTHESIS AND BINDING STUDY OF PYRAZOLO[4,5-C][1,8]NAPHTHYRIDINES.. IL FARMACO, vol. 42, pp. 671-680, ISSN:0014-827X

V. Colotta; L. Cecchi; ; G. Filacchioni; F. Melani; G. Palazzino; C. Martini; A. Lucacchini. (1987). [1]Benzopyrano-pyrazole-4-ones. Synthesis, binding studies and structure-activity relationships. In: French-italian joint meeting on Medicinal Chemistry, Pisa, Settembre 1987, d, pp. 104-104.

G. PALAZZINO; L. CECCHI; F. MELANI; V. COLOTTA; G. FILACCHIONI; C. MARTINI; A. LUCACCHINI (1987). 1,3-DIARYLPYRAZOLO[4,5-C]- AND -[5,4-C]QUINOLIN-4-ONES. 4. SYNTHESIS AND SPECIFIC INHIBITION OF BENZODIAZEPINE RECEPTOR BINDING.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 30, pp. 1737-1742, ISSN:0022-2623

L. Cecchi; V. Colotta; G. Filacchioni; F. Melani; G. Palazzino (1986). Sistemi eterociclici azotati con affinità per il recettore benzodiazepinico. In: VI Convegno Nazionale della Divisione di Chimica Farmaceutica della SCI, Alghero, Ottobre 1986, d, pp. 25-25.

E. TEODORI; F. MELANI; F. GUALTIERI (1986). 13C NMR SPECTRA OF 1,3-OXATHIOLANE, 1,3-OXATHIOLANE-3-OXIDE AND 1,3-OXATHIOLANE-3,3-DIOXIDE DERIVATIVES. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 27, pp. 1478-1490, ISSN:0022-152X

G. PALAZZINO; F. MELANI; L. CECCHI; G. FILACCHIONI (1986). . PYRROLNITRIN ANALOGS. XII. SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME PYRAZOLE CARBOXYLIC ACIDS.. IL FARMACO, vol. 41, pp. 566-576, ISSN:0014-827X

F. MELANI; L. CECCHI; G. PALAZZINO; G. FILACCHIONI (1986). SYNTHESIS OF PYRAZOLO[4,5-D]- AND PYRAZOLO[4,5-C][1]BENZAZEPINE DERIVATIVES. IV.. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 23, pp. 173-176, ISSN:0022-152X

F. MELANI; L. CECCHI; G. PALAZZINO; G. FILACCHIONI; C. MARTINI; A. LUCACCHINI; E. PENNACCHI (1986). PYRAZOLO[4,5-C]QUINOLINES. 3. SYNTHESIS, RECEPTOR BINDING, AND 13C-NMR STUDY.. JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 75, pp. 1175-1179, ISSN:0022-3549

F. MELANI; L. CECCHI; G. PALAZZINO; G. FILACCHIONI; C. MARTINI; E. PENNACCHI; A. LUCACCHINI (1986). PYRAZOLO[4,5-C]QUINOLINES. SYNTHESIS AND SPECIFIC INHIBITION OF BENZODIAZEPINE RECEPTOR BINDING.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 29, pp. 291-295, ISSN:0022-2623

F. MELANI; L. CECCHI; G. PALAZZINO; G. FILACCHIONI (1985). SYNTHESIS AND CARBON-13 NMR STUDY OF PYRAZOLO[4,5-C]- AND PYRAZOLO[4,3-C][1]BENZAZEPINES. III.. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 22, pp. 1109-1112, ISSN:0022-152X

L. CECCHI; F. MELANI; G. PALAZZINO; G. FILACCHIONI; C. MARTINI; E. PENNACCHI; A. LUCACCHINI (1985). SYNTHESIS AND BINDING STUDIES OF 1-ARYLPYRAZOLO[4,5-C]- AND 2-ARYLPYRAZOLO[4,3-C]QUINOLIN-4-ONES.. IL FARMACO, vol. 40, pp. 509-516, ISSN:0014-827X

L. CECCHI; F. MELANI; G. PALAZZINO; G. FILACCHIONI; G. PORRETTA (1984). PYRROLNITRIN ANALOGS. IX. SYNTHESIS AND BIOLOGICAL ACTIVITY OF 1-TOLYL-3-NITROPHENYL-5-METHYLPYRAZOLE-4-CARBOXYLIC ACIDS AND 1-TOLYL-3-METHYL-5-NITROPHENYLPYRAZOLE-4-CARBOXYLIC ACIDS. FARMACO, EDIZIONE SCIENTIFICA (1984), 39(10), 888-900.. IL FARMACO, vol. 39, pp. 888-900, ISSN:0014-827X

L. CECCHI; F. MELANI; G. PALAZZINO; G. FILACCHIONI (1984). PYRROLNITRIN ANALOGS. X. SYNTHESIS AND BIOLOGICAL ACTIVITY OF 1-CHLOROPHENYL-3- OR -5-NITROPHENYLPYRAZOLE-4-CARBOXYLIC ACIDS.. IL FARMACO, vol. 39, pp. 953-962, ISSN:0014-827X

L. Cecchi; F. Melani; G.Filacchioni; M. Tredici (1984). Synthesis and biological activity of some 3-(pyrazol-1'-yl)indazole derivatives. IL FARMACO, vol. 39, pp. 945-952, ISSN:0014-827X

F. MELANI; L. CECCHI; G. FILACCHIONI (1984). SYNTHESIS OF 5H-10,11-DIHYDROPYRAZOLO[5,1-C][1,4]BENZODIAZEPINE DERIVATIVES. II.. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 21, pp. 813-815, ISSN:0022-152X

Fabrizio MELANI

Biography

Fabrizio Melani was a university teacher.

His work history began as a chemist in a chemical industry, and later he worked at the University of Florence with a qualification as a Technician. After obtaining a degree in Pharmacy he took on the role of Associate Professor in Pharmaceutical Chemistry.

The work experience, aimed at industrial production, was useful to him to pass on to students a knowledge that was not only academic but as relevant as possible to the reality of the profession of chemist.

He had experiences in the chemical field regarding the synthesis of active molecules in the biological field and analytical techniques. He also acquired experience in the field of "virtual chemistry" using and also writing algorithms capable of simulating and predicting the behavior of molecules in a biological environment also making use of both statistics and artificial intelligence.

Fabrizio Melani was, for several years, director of the Department of Pharmaceutical Sciences

Currently, despite being retired, he continues to collaborate with various research groups both in the chemical-pharmaceutical and chemical-food fields. He cultivates a passion for mountain bike excursions and for the sport of archery, being part of an Archery Company of which he is also President.

Fabrizio MELANI

Curriculum

Education

1973: Industrial Chemical Expert Diploma

1983: Degree in PHARMACY obtained from the University of Florence

Professional and academic activity

1976-1981: Chief Technical Assistant at the general analysis laboratory of the SOLVAY plant in Rosignano S.

1981-1992: Technician at the University of Florence

1992-2021: Associate Professor of Pharmaceutical and Toxicological Chemistry at the Faculty of Pharmacy of the University of Florence.

2009-2012 Director of the Department of Pharmaceutical Sciences

Teaching activity

1992-1994: Teacher of EXERCISES OF PHARMACEUTICAL AND TOXICOLOGICAL CHEMISTRY III (degree course in Pharmacy)

1994-2000: Teacher of PHARMACEUTICAL AND TOXICOLOGICAL CHEMISTRY III (degree course in CTF)

1999-2021: Teacher of DRUG ANALYSIS I (degree course in CTF)

2005-2021: Teacher of DRUG ANALYSIS I (degree course in PHARMACY)

2005 to 2008: Teacher of MOLECULAR MODELING (module) (degree course in PHARMACEUTICAL BIOTECHNOLOGY)

2010-2021: Teacher of advanced course in MOLECULAR MODELING in CHEMISTRY PHARMACEUTICAL

Fabrizio MELANI

Interest

Fabrizio Melani’s current interests are focused on the application of artificial intelligence to support molecular modeling studies and the processing of analytical data in the context of collaborations with various research groups. Outside the professional field, his interests are focused on nature, which materialize in frequent excursions and sports activities such as mountain biking and archery.