Personale

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Orario di ricevimento

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Curriculum

Pubblicazioni

Insegnamenti

English

Biography

Corrado POGGESI

Ruolo attuale:: Professore Ordinario Emerito
SSD:: BIO/09 - Fisiologia
Afferenza organizzativa:: Dipartimento di Medicina Sperimentale e Clinica

Recapiti

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	corrado.poggesi(AT)unifi.it

Corrado POGGESI

Curriculum

Nato a Brescia il 14 Ottobre 1950. Laureato con lode in Medicina e Chirurgia (1975) presso l’Università di Pavia (alunno del Collegio Ghislieri).

Dal 2021 Professore Emerito di Fisiologia dell'Università di Firenze.

Carriera accademica presso le Facoltà di Medicina dell’Università di Pavia (1975-1987) e dell’Università di Firenze (1987-2020). Professore Ordinario di Fisiologia dal 1994.

Attività istituzionale

Attualmente membro designato dal Ministero dell’Università e Ricerca (MUR) del Direttivo dell’Istituto Nazionale di Ricerche Cardiovascolari (INRC).

2013-2020 Direttore del Dipartimento di Medicina Sperimentale e Clinica dell’Università di Firenze

2018-2020 Presidente della Società Italiana di Fisiologia

2018-2021 Presidente della Commissione Nazionale per l’abilitazione a professore per il settore Fisiologia.

2008-2012 Membro del Senato Accademico dell’Università di Firenze

2008-2011 Membro del Direttivo della Società Italiana di Fisiologia

2006-2008 Direttore del Dipartimento di Scienze Fisiologiche

2000-2010 Coordinatore della Scuola di Dottorato di Scienze Fisiologiche e Nutrizionali

Attività Editoriale

Senior Consultant Editor del Journal of Molecular and Cellular Cardiology; Associate Editor di Frontiers in Physiology: Striated Muscle Physiology; Membro dell’Editorial Board del Journal of Cardiovascular Translational Research (2010-2023); Editore di un numero speciale del Journal of Muscle Research and Cell Motility (2023-2024); Attività di Revisore per numerose riviste scientifiche e per agenzie di finanziamento internazionali.

Soggiorni scientifici all’estero

1985-1987 Senior research fellow presso il Department of Pharmacology, Mayo Clinic (Rochester, MN, USA).

2003 Visiting Scientist, Department of Physiology & Biophysics, UCLA (Los Angeles, CA, USA).

Brevi soggiorni di lavoro presso INSERM CNRS Montpellier; Columbia University, New York; University of Washington, Seattle; University of Illinois, Chicago; Loyola University, Chicago.

Finanziamenti di ricerca

Ha ricevuto numerosi finanziamenti dall’Unione Europea, MUR, Telethon.

Attualmente collabora ai seguenti progetti Europei:

• EU Horizon-HLTH-2023-Tool-05-03: progetto SMASH-HCM GA n. 101137115: Stratification, Management, and Guidance of Hypertrophic Cardiomyopathy Patients using Hybrid Digital Twin Solutions. 2023-2026.

• EU Horizon 2020 Future and Emerging Technologies: progetto REPAIR GA n. 952166 Restoring Cardiac Mechanical Function by Polymeric Artificial Muscular Tissue. 2020 - 2025.

L’attività di ricerca riguarda tematiche relative al meccanismo contrattile del muscolo scheletrico e cardiaco (accoppiamento eccitazione-contrazione, regolazione della contrazione, trasduzione chemo-meccanica alla base della contrazione). Nel suo laboratorio sono state sviluppate tecniche micromeccaniche e di microperfusione per lo studio della meccanica del sarcomero in miofibrille isolate dal muscolo scheletrico e cardiaco umano e di modelli animali. Queste tecniche sono state applicate con successo anche allo studio di miopatie e cardiomiopatie di origine genetica. Tali tecniche sono state riprodotte in diversi laboratori internazionali. In tempi più recenti ha contribuito, in collaborazione con ricercatori CNR, allo sviluppo di nuove tecniche ottiche per lo studio dei meccanismi aritmogenici e di accoppiamento eccitazione-contrazione nel muscolo cardiaco. E’ autore di oltre 135 lavori in extenso con oltre 5000 citazioni e un indice h di 44 (WOS).

Corrado POGGESI

Pubblicazioni

Legenda

Contributo su rivista |

Articolo su libro |

Libro |

Contributo in atti di convegno (proceeding) |

Brevetto |

Curatela | Altro

Altro |

Tesi di Dottorato

Langione, Marianna; Giammarino, Lucrezia; Semeraro, Roberto; Steczina, Sonette; Olianti, Camilla; Magi, Alberto; Sacconi, Leonardo; Olivotto, Iacopo; Tesi, Chiara; Regnier, Michael; Poggesi, Corrado; Coppini, Raffaele; Ferrantini, Cecilia; Pioner, J. Manuel (2025). BPS2025 - Long-term effect of Mavacamten impact force and sarcomere density in a MYBPC3 iPSC-cardiomyocyte model of hypertrophic cardiomyopathy. BIOPHYSICAL JOURNAL, vol. 124, pp. 0-0, ISSN:0006-3495 DOI

Pioner, JM ; Pierantozzi, Enrico; Coppini, Raffaele; Rubino, Egidio Maria; Biasci, Valentina; Vitale, Giulia; Laurino, Annunziatina; Santini, Lorenzo; Scardigli, Marina; Randazzo, Davide; Olianti, Camilla; Serano, Matteo; Rossi, Daniela; Tesi, Chiara; Cerbai, Elisabetta; Lange, Stephan; Reggiani, Carlo; Sacconi, Leonardo; Poggesi, Corrado; Ferrantini, Cecilia; Sorrentino, Vincenzo (2025). Obscurin deficiency leads to compensated dilated cardiomyopathy and increased arrhythmias. JOURNAL OF GENERAL PHYSIOLOGY, vol. 157, pp. 0-0, ISSN:0022-1295 DOI Accesso ONLINE all'editore

Mattioli, Anna Vittoria; Coppi, Francesca; Severino, Paolo; Penna, Claudia; Pagliaro, Pasquale; Dei Cas, Alessandra; Bucciarelli, Valentina; Madonna, Rosalinda; Tarperi, Cantor; Schena, Federico; Cetrullo, Silvia; Angelone, Tommaso; Rocca, Carmine; Parenti, Astrid; Palazzuoli, Alberto; Margonato, Alberto; Paolillo, Stefania; Perrone Filardi, Pasquale; Barillà, Francesco; Lombardi, Carlo; Pinti, Marcello; Molinari, Claudio; Cevese, Antonio; Novo, Giuseppina; Pizzi, Carmine; Porto, Italo; Poggesi, Corrado; Gallina, Sabina; Ambrosio, Giuseppe; Fedele, Francesco; null, null (2024). A Personalized Approach to Vitamin D Supplementation in Cardiovascular Health Beyond the Bone: An Expert Consensus by the Italian National Institute for Cardiovascular Research. NUTRIENTS, vol. 17, pp. 0-28, ISSN:2072-6643 DOI Accesso ONLINE all'editore

Scardigli, Marina; Pásek, Michal; Santini, Lorenzo; Palandri, Chiara; Conti, Emilia; Crocini, Claudia; Campione, Marina; Loew, Leslie M.; de Vries, Antoine A. F.; Pijnappels, Daniël A.; Pavone, Francesco S.; Poggesi, Corrado; Cerbai, Elisabetta; Coppini, Raffaele; Kohl, Peter; Ferrantini, Cecilia; Sacconi, Leonardo (2024). Optogenetic confirmation of transverse‐tubular membrane excitability in intact cardiac myocytes. THE JOURNAL OF PHYSIOLOGY, vol. 602, pp. 791-808, ISSN:0022-3751 DOI

Steczina Sonette, Saffie Mohran, Logan R.J. Bailey, Timothy S. McMillen, Kristina B. Kooiker, Neil B. Wood, Jennifer Davis, Michael J. Previs, Iacopo Olivotto, J.M. Pioner, Michael A. Geeves, Corrado Poggesi, Michael Regnier (2024). MYBPC3-c.772G > a mutation results in haploinsufficiency and altered myosin cycling kinetics in a patient induced stem cell derived cardiomyocyte model of hypertrophic cardiomyopathy. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, pp. 0-0, ISSN:1095-8584 DOI

Scellini, Beatrice; Piroddi, Nicoletta; Dente, Marica; Pioner, J. Manuel; Ferrantini, Cecilia; Poggesi, Corrado; Tesi, Chiara (2024). Myosin isoform-dependent effect of omecamtiv mecarbil on the regulation of force generation in human cardiac muscle. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 25, pp. 0-0, ISSN:1422-0067 DOI

Mastrototaro G.; Carullo P.; Zhang J.; Scellini B.; Piroddi N.; Nemska S.; Filomena M.C.; Serio S.; Otey C.A.; Tesi C.; Emrich F.; Linke W.A.; Poggesi C.; Boncompagni S.; Bang M.-L. (2023). Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities. ELIFE, vol. 12, pp. 0-0, ISSN:2050-084X DOI Accesso ONLINE all'editore

PIONER, JOSE' MANUEL; Vitale, Giulia, Steczina Sonette, Langione Marianna, Margara Francesca; Santini, Lorenzo; Giardini, Francesco; Lazzeri, Erica; Piroddi, Nicoletta; Scellini, Beatrice; Palandri, Chiara; Schuldt, Maike; Spinelli, Valentina; Girolami, Francesca; Mazzarotto, Francesco; van der Velden, Jolanda; Cerbai, Elisabetta; Tesi, Chiara; Olivotto, Iacopo; Bueno-Orovio, Alfonso; Sacconi, Leonardo; Coppini, Raffaele; Ferrantini, Cecilia; Regnier, Michael; Poggesi, Corrado (2023). Slower Calcium Handling Balances Faster Cross-Bridge Cycling in Human MYBPC3 HCM. CIRCULATION RESEARCH, vol. 132, pp. 628-644, ISSN:0009-7330 DOI Accesso ONLINE all'editore

Beltrami, Matteo; Fedele, Elisa; Fumagalli, Carlo; Mazzarotto, Francesco; Girolami, Francesca; Ferrantini, Cecilia; Coppini, Raffaele; Tofani, Lorenzo; Bertaccini, Bruno; Poggesi, Corrado; Olivotto, Iacopo (2023). Long-Term Prevalence of Systolic Dysfunction in MYBPC3 Versus MYH7-Related Hypertrophic Cardiomyopathy. CIRCULATION, pp. 1-9, ISSN:2574-8300 DOI Accesso ONLINE all'editore

Beatrice Scellini, Nicoletta Piroddi , Marica Dente , Giulia Vitale , Josè Manuel Pioner , Raffaele Coppini , Cecilia Ferrantini , Corrado Poggesi , Chiara Tesi (2022). EFFECTS OF MAVACAMTEN, A FIRST-IN-CLASS INHIBITOR OF SARCOMERIC MYOSINS, ON THE MECHANICS OF ATRIAL AND VENTRICULAR MAMMALIAN MYOCARDIUM AND FAST SKELETAL MUSCLE. (Tutor: Prof. Chiara Tesi)

Coppini, Raffaele; Beltrami, Matteo; Doste, Ruben; Bueno-Orovio, Alfonso; Ferrantini, Cecilia; Vitale, Giulia; Pioner, JM; Santini, Lorenzo; Argirò, Alessia; Berteotti, Martina; Mori, Fabio; Marchionni, Niccolò; Stefàno, Pierluigi; Cerbai, Elisabetta; Poggesi, Corrado; Olivotto, Iacopo (2022). Paradoxical prolongation of QT interval during exercise in patients with hypertrophic cardiomyopathy: cellular mechanisms and implications for diastolic function. EUROPEAN HEART JOURNAL OPEN, vol. 2, pp. 0-0, ISSN:2752-4191 DOI

Josè Manuel Pioner, Giulia Vitale, Francesca Gentile, Beatrice Scellini, Nicoletta Piroddi, Elisabetta Cerbai, Iacopo Olivotto, Jil Tardiff, Raffaele Coppini, Chiara Tesi, Corrado Poggesi, Cecilia Ferrantini (2022). Genotype-Driven Pathogenesis of Atrial Fibrillation in Hypertrophic Cardiomyopathy: The Case of Different TNNT2 Mutations. FRONTIERS IN PHYSIOLOGY, pp. 0-0, ISSN:1664-042X DOI Accesso ONLINE all'editore

Querceto S.; Santoro R.; Gowran A.; Grandinetti B.; Pompilio G.; Regnier M.; Tesi C.; Poggesi C.; Ferrantini C.; Pioner J.M. (2022). The harder the climb the better the view: The impact of substrate stiffness on cardiomyocyte fate. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, vol. 166, pp. 36-49, ISSN:0022-2828 DOI

Vitale, G; Grandinetti, B; Querceto, S; Martella, D; Tesi, C; Poggesi, C; Cerbai, E; Wiersma, DS; Parmeggiani, C; Ferrantini, C; Sacconi, L (2022). Photoresponsive Polymer-Based Biomimetic Contractile Units as Building Block for Artificial Muscles. MACROMOLECULAR MATERIALS AND ENGINEERING, vol. 307, pp. 0-0, ISSN:1438-7492 DOI

Pioner, J.M.; Santini, Lorenzo; Palandri, Chiara; Langione, Marianna; Grandinetti, Bruno; Querceto, Silvia; Martella, Daniele; Mazzantini, Costanza; Scellini, Beatrice; Giammarino, Lucrezia; Lupi, Flavia; Mazzarotto, Francesco; Gowran, Aoife; Rovina, Davide; Santoro, Rosaria; Pompilio, Giulio; Tesi, Chiara; Parmeggiani, Camilla; Regnier, Michael; Cerbai, Elisabetta; Mack, David L.; Poggesi, Corrado; Ferrantini, Cecilia; Coppini, Raffaele (2022). Calcium handling maturation and adaptation to increased substrate stiffness in human iPSC-derived cardiomyocytes: The impact of full-length dystrophin deficiency. FRONTIERS IN PHYSIOLOGY, vol. 13, pp. 0-0, ISSN:1664-042X DOI Accesso ONLINE all'editore

Ferrantini, Cecilia; Scellini, Beatrice; Vitale, Giulia; Pioner, Jose' Manuel; Querceto, Silvia; Coppini, Raffaele; Piroddi, Nicoletta; Poggesi, Corrado; Tesi, Chiara (2022). Mavacamten depresses human atrial contractility in the same EC50% range as human ventricle. BIOPHYSICAL JOURNAL, vol. 121, pp. 106a-107a, ISSN:0006-3495 DOI

Pioner, Jose' Manuel; Vitale, Giulia; Santini, Lorenzo; Palandri, Chiara; Bueno-Orovio, Alfonso; Margara, Francesca; Piroddi, Nicoletta; Scellini, Beatrice; Tesi, Chiara; Coppini, Raffaele; Ferrantini, Cecilia; Poggesi, Corrado (2022). Contraction and electrophysiological abnormalities in myofilament mutation-positive and mutation-negative human HCM myocardium. BIOPHYSICAL JOURNAL, vol. 121, pp. 435a-436a, ISSN:0006-3495 DOI

Biasci, V; Santini, L; Marchal, G A; Hussaini, S; Ferrantini, C; Coppini, R; Loew, L M; Luther, S; Campione, M; Poggesi, C; Pavone, F S; Cerbai, E; Bub, G; Sacconi, L (2022). Optogenetic manipulation of cardiac electrical dynamics using sub-threshold illumination: dissecting the role of cardiac alternans in terminating rapid rhythms. BASIC RESEARCH IN CARDIOLOGY, vol. 117, pp. 0-0, ISSN:1435-1803 DOI

Srboljub M Mijailovich, Momcilo Prodanovic , Corrado Poggesi , Michael A Geeves , Michael Regnier (2021). Multiscale modeling of twitch contractions in cardiac trabeculae. JOURNAL OF GENERAL PHYSIOLOGY, vol. 153, pp. 0-0, ISSN:0022-1295 DOI

Walklate J.; Ferrantini C.; Johnson C.A.; Tesi C.; Poggesi C.; Geeves M.A. (2021). Alpha and beta myosin isoforms and human atrial and ventricular contraction. CELLULAR AND MOLECULAR LIFE SCIENCES, pp. 1-29, ISSN:1420-682X DOI

Vitale G.; Coppini R.; Tesi C.; Poggesi C.; Sacconi L.; Ferrantini C. (2021). T-tubule remodeling in human hypertrophic cardiomyopathy. JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, vol. 42, pp. 305-322, ISSN:0142-4319 DOI

Filomena M.C.; Yamamoto D.L.; Carullo P.; Medvedev R.; Ghisleni A.; Piroddi N.; Scellini B.; Crispino R.; D'autilia F.; Zhang J.; Felicetta A.; Nemska S.; Serio S.; Tesi C.; Catalucci D.; Linke W.A.; Polishchuk R.; Poggesi C.; Gautel M.; Bang M.-L. (2021). Myopalladin knockout mice develop cardiac dilation and show a maladaptive response to mechanical pressure overload. ELIFE, vol. 10, pp. e58313-e58313, ISSN:2050-084X DOI

Ferrantini, Cecilia; Poggesi, Corrado (2021). Sealing t-tubules increases the energy cost of cardiac contraction. ACTA PHYSIOLOGICA, vol. 231, pp. 0-0, ISSN:1748-1716 DOI

Scellini B.; Piroddi N.; Dente M.; Vitale G.; Pioner J.M.; Coppini R.; Ferrantini C.; Poggesi C.; Tesi C. (2021). Mavacamten has a differential impact on force generation in myofibrils from rabbit psoas and human cardiac muscle. JOURNAL OF GENERAL PHYSIOLOGY, vol. 153, pp. e202012789-e202012789, ISSN:0022-1295 DOI

Giardini F.; Lazzeri E.; Vitale G.; Ferrantini C.; Costantini I.; Pavone F.S.; Poggesi C.; Bocchi L.; Sacconi L. (2021). Quantification of Myocyte Disarray in Human Cardiac Tissue. FRONTIERS IN PHYSIOLOGY, vol. 12, pp. 750364-750364, ISSN:1664-042X DOI

Vitale G.; Ferrantini C.; Piroddi N.; Scellini B.; Pioner J.M.; Colombini B.; Tesi C.; Poggesi C. (2021). The relation between sarcomere energetics and the rate of isometric tension relaxation in healthy and diseased cardiac muscle. JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, vol. 42, pp. 47-57, ISSN:0142-4319 DOI Accesso ONLINE all'editore

Mijailovich SM, Prodanovic M, Poggesi C, Powers JD, Davis J, Geeves MA, Regnier M. (2021). The effect of variable troponin C mutation thin filament incorporation on cardiac muscle twitch contractions. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, vol. 155, pp. 112-124, ISSN:0022-2828

Pioner, J. M.; Guan, Xuan; Klaiman, Jordan M; Racca, Alice W; Pabon, Lil; Muskheli, Veronica; Macadangdang, Jesse; Ferrantini, Cecilia; Hoopmann, Michael R; Moritz, Robert L; Kim, Deok-Ho; Tesi, Chiara; Poggesi, Corrado; Murry, Charles E; Childers, Martin K; Mack, David L; Regnier, Michael (2020). Absence of full-length dystrophin impairs normal maturation and contraction of cardiomyocytes derived from human induced pluripotent stem cells. CARDIOVASCULAR RESEARCH, pp. 0-0, ISSN:0008-6363 DOI

Filomena, MC; Yamamoto, DL; Carullo, P; Piroddi, N; Tesi, C; Scellini, B; Crispino, R; Zhang, J; Knoll, R; Polishchuk, R; Poggesi, C; Bang, ML (2020). Myopalladin is upregulated in dilated cardiomyopathies patients and myopalladin knockout mice develop cardiac dilation and dysfunction following pressure overload. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, vol. 140, pp. 43-43, ISSN:0022-2828 DOI

Scellini, Beatrice; Piroddi, Nicoletta; Dente, Marica; Ferrantini, Cecilia; Coppini, Raffaele; Poggesi, Corrado; Tesi, Chiara (2020). Impact of Mavacamten on Force Generation in Single Myofibrils from Rabbit Psoas and Human Cardiac Muscle. BIOPHYSICAL JOURNAL, vol. 118, pp. 7a-7a, ISSN:0006-3495 DOI

Lazzeri, Erica; Giardini, Francesco; Costantini, Irene; Silvestri, Ludovico; Coppini, Raffaele; Ferrantini, Cecilia; Mazzamuto, Giacomo; Muellenbroich, Caroline; Loew, Leslie M.; Bocchi, Leonardo; Cerbai, Elisabetta; Poggesi, Corrado; Bishop, Martin J.; Pavone, Francesco S.; Sacconi, Leonardo (2020). Structural Mapping of Action Potential Propagation Pathways through Healthy and Diseased Heart. In: 64th Annual Meeting of the Biophysical-Society, CELL PRESS, vol. 118, pp. 493a-493a. DOI

Querceto, Silvia; Ferrantini, Cecilia; Grandinetti, Bruno; Martella, Daniele; Manuel Pioner, José; Sybolt Wiersma, Diederik; Cerbai, Elisabetta; Saverio Pavone, Francesco; Tesi, Chiara; Poggesi, Corrado; Sacconi, Leonardo; Parmeggiani, Camilla (2020). Microled Illumination Towards Liquid Crystalline Elastomers Based Cardiac Contraction Assistance. BIOPHYSICAL JOURNAL, vol. 118, pp. 424a-425a, ISSN:0006-3495 DOI

Mazzarotto F.; Olivotto I.; Boschi B.; Girolami F.; Poggesi C.; Barton P.J.R.; Walsh R. (2020). Contemporary Insights Into the Genetics of Hypertrophic Cardiomyopathy: Toward a New Era in Clinical Testing?. JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE, vol. 9, pp. 0-0, ISSN:2047-9980 DOI

Nijenkamp LLAM, Bollen IAE, Niessen HWM, Dos Remedios CG, Michels M, Poggesi C, Ho CY, Kuster DWD, van der Velden J. (2020). Sex-specific cardiac remodeling in early and advanced stages of hypertrophic cardiomyopathy.. PLOS ONE, vol. 15:e0232427, pp. 0-0, ISSN:1932-6203 DOI

Pioner JM, Fornaro A, Coppini R, Ceschia N, Sacconi L, Donati MA, Favilli S, Poggesi C, Olivotto I, Ferrantini C (2020). Advances in Stem Cell Modeling of Dystrophin-Associated Disease: Implications for the Wider World of Dilated Cardiomyopathy. FRONTIERS IN PHYSIOLOGY, pp. 0-0, ISSN:1664-042X DOI

Piroddi N, Pesce P, Scellini B, Manzini S, Ganzetti GS, Badi I, Menegollo M, Cora V, Tiso S, Cinquetti R, Monti L, Chiesa G, Bleyl SB, Busnelli M, Dellera F, Bruno D, Caicci F, Grimaldi A, Taramelli R, Manni L, Sacerdoti D, Tesi C, Poggesi C, Ausoni S, Acquati F, Campione M (2020). Myocardial overexpression of ANKRD1 causes sinus venosus defects and progressive diastolic dysfunction.. CARDIOVASCULAR RESEARCH, vol. 116, pp. 1458-1472, ISSN:1755-3245 DOI

Vitale, G; Lazzeri, E; Costantini, I; Giardini, F; Mazzamuto, G; Crocini, C; Piroddi, N; Scellini, B; Pioner, JM; Ferrantini, C; Tesi, C; Pavone, FS; Sacconi, L; Poggesi, C (2019). Advanced Morpho-Functional Analysis on Ventricular and Atrial Tissue Reveals Cross-Bridge Kinetics Alterations and Sarcomere Energetic Impairment in Hcm Patients. BIOPHYSICAL JOURNAL, vol. 116, pp. 29A-29A, ISSN:0006-3495 DOI

Ferrantini, C; Pioner, JM; Martella, D; Coppini, R; Piroddi, N; Paoli, P; Calamai, M; Pavone, FS; Wiersma, D; Tesi, C; Cerbai, E; Poggesi, C; Sacconi, L; Parmeggiani, C (2019). Design of Biocompatible Liquid Cristal Elastomers Reproducing the Mechanical Properties of Human Cardiac Muscle. BIOPHYSICAL JOURNAL, vol. 116, pp. 264A-264A, ISSN:0006-3495 DOI

B. Scellini, N. Piroddi, M. Dente, C. Ferrantini, R. Coppini, C.Poggesi, C. Tesi (2019). Time resolved depression of isometric force by Mavacamten in single myofibrils from rabbit psoas and human cardiac muscle. JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, vol. 40, pp. 230-230, ISSN:0142-4319 DOI Accesso ONLINE all'editore

Coppini, Raffaele; Ferrantini, Cecilia; Pioner, Josè Manuel; Santini, Lorenzo; Wang, Zhinuo J.; Palandri, Chiara; Scardigli, Marina; Vitale, Giulia; Sacconi, Leonardo; Stefàno, Pierluigi; Flink, Laura; Riedy, Katherine; Pavone, Francesco Saverio; Cerbai, Elisabetta; Poggesi, Corrado; Mugelli, Alessandro; Bueno-Orovio, Alfonso; Olivotto, Iacopo; Sherrid, Mark V. (2019). Electrophysiological and Contractile Effects of Disopyramide in Patients With Obstructive Hypertrophic Cardiomyopathy: a Translational Study. JACC. BASIC TO TRANSLATIONAL SCIENCE, pp. 0-0, ISSN:2452-302X DOI

Piroddi, Nicoletta; Witjas-Paalberends, E. Rosalie; Ferrara, Claudia; Ferrantini, Cecilia; Vitale, Giulia; Scellini, Beatrice; Wijnker, Paul J.M.; Sequiera, Vasco; Dooijes, Dennis; dos Remedios, Cristobal; Schlossarek, Saskia; Leung, Man Ching; Messer, Andrew; Ward, Douglas G.; Biggeri, Annibale; Tesi, Chiara; Carrier, Lucie; Redwood, Charles S.; Marston, Steven B.; van der Velden, Jolanda; Poggesi, Corrado (2019). The homozygous K280N troponin T mutation alters cross-bridge kinetics and energetics in human HCM. JOURNAL OF GENERAL PHYSIOLOGY, vol. 151, pp. 18-29, ISSN:0022-1295 DOI Accesso ONLINE all'editore

Crocini C.; Ferrantini C.; Coppini R.; Pavone F.S.; Poggesi C.; Cerbai E.; Sacconi L. (2019). Letter to the Editor. THE JOURNAL OF PHYSIOLOGY, vol. 597, pp. 2965-2966, ISSN:0022-3751 DOI Accesso ONLINE all'editore

Pioner J.M.; Santini L.; Palandri C.; Martella D.; Lupi F.; Langione M.; Querceto S.; Grandinetti B.; Balducci V.; Benzoni P.; Landi S.; Barbuti A.; Lupi F.F.; Boarino L.; Sartiani L.; Tesi C.; Mack D.L.; Regnier M.; Cerbai E.; Parmeggiani C.; Poggesi C.; Ferrantini C.; Coppini R. (2019). Optical investigation of action potential and calcium handling maturation of hiPSC-cardiomyocytes on biomimetic substrates. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 20, pp. 0-0, ISSN:1661-6596 DOI Accesso ONLINE all'editore

Woulfe, Kathleen C; Ferrara, Claudia; Pioner, Jose Manuel; Mahaffey, Jennifer H; Coppini, Raffaele; Scellini, Beatrice; Ferrantini, Cecilia; Piroddi, Nicoletta; Tesi, Chiara; Poggesi, Corrado; Jeong, Mark (2019). A Novel Method of Isolating Myofibrils From Primary Cardiomyocyte Culture Suitable for Myofibril Mechanical Study. FRONTIERS IN CARDIOVASCULAR MEDICINE, vol. 6, pp. 0-0, ISSN:2297-055X DOI

Ferrantini, Cecilia; Pioner, Josè Manuel; Martella, Daniele; Coppini, Raffaele; Piroddi, Nicoletta; Paoli, Paolo; Calamai, Martino; Pavone, Francesco; Wiersma, Diederik Sybolt; Tesi, Chiara; Cerbai, Elisabetta; Poggesi, Corrado; Sacconi, Leonardo; Parmeggiani, Camilla (2019). Development of Light-Responsive Liquid Crystalline Elastomers to Assist Cardiac Contraction. CIRCULATION RESEARCH, vol. 124, pp. 44-54, ISSN:0009-7330 DOI

Nijenkamp, Louise L A M; Bollen, Ilse A E; van Velzen, Hannah G; Regan, Jessica A; van Slegtenhorst, Marjon; Niessen, Hans W M; Schinkel, Arend F L; Krüger, Martina; Poggesi, Corrado; Ho, Carolyn Y; Kuster, Diederik W D; Michels, Michelle; van der Velden, Jolanda (2018). Sex Differences at the Time of Myectomy in Hypertrophic Cardiomyopathy. CIRCULATION. HEART FAILURE, vol. 11, pp. 0-0, ISSN:1941-3289 DOI

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R. Coppini;C. Ferrantini;A. Aiazzi;L. Mazzoni;L. Sartiani;A. Mugelli;C. Poggesi;E. Cerbai (2014). Isolation and functional characterization of human ventricular cardiomyocytes from fresh surgical samples.. JOURNAL OF VISUALIZED EXPERIMENTS, pp. ---, ISSN:1940-087X DOI Accesso ONLINE all'editore

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Beatrice Scellini; Claudia Ferrara; Nicoletta Piroddi; John Sumida; Corrado Poggesi; Sherwin S. Lehrer; Chiara Tesi (2012). Tropomyosin D137L of reduced flexibility increases submaximal calcium-activated tension in skeletal muscle myofibrils after troponin-tropomyosin removal and reconstitution. BIOPHYSICAL JOURNAL, vol. 102(3), pp. 230a-231a, ISSN:0006-3495

Ferrara C; Piroddi N; Scellini B; Ferrantini C; Sequiera V; Remedios C; Carrier L; Tesi C ; Van Der Velden J; Poggesi C. (2012). The HCM-associated cardiac Troponin T mutation K280N accelerates tension generation and relaxation in human cardiac myofibrils. CARDIOVASCULAR RESEARCH, vol. 93 (1), pp. S24-S24, ISSN:0008-6363

Jeong M.; Ferrara C.; Ferrantini C.; Coppini R.; Scellini B.; Piroddi N.; Tesi C.; Cerbai E.; Poggesi C. (2012). Novel method of obtaining myofibrils from cardiomyocyte cultures. JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, vol. 33, pp. 247-247, ISSN:0142-4319

Sacconi L; Ferrantini C; Lotti J; Coppini R; Yan P; Loew LM; Tesi C; Cerbai E; Poggesi C; Pavone FS. (2012). Action potential propagation in transverse-axial tubular system is impaired in heart failure. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 109, pp. 5815-5819, ISSN:1091-6490

Scellini B.; Ferrara C.; Piroddi N.; Sumida J.; Poggesi C.; Lehrer S.S.; Tesi C. (2012). Tropomyosin flexibility modulates Ca2+ sensitivity of thin filament and affects tension relaxation in skeletal muscle myofibrils after troponin-tropomyosin removal and reconstitution. JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, vol. 33, pp. 246-246, ISSN:0142-4319

Janco M; Kalyva A; Scellini B; Piroddi N; Tesi C; Poggesi C; Geeves MA. (2012). α-Tropomyosin with a D175N or E180G Mutation in Only One Chain Differs from Tropomyosin with Mutations in Both Chains.. BIOCHEMISTRY, vol. 51, pp. 9880-9890, ISSN:0006-2960 DOI

K.L. Kreutziger; N. Piroddi; J. T. McMichael; C. Tesi; C. Poggesi; M. Regnier (2011). Calcium binding kinetics of troponin C strongly modulate cooperative activation and tension kinetics in cardiac muscle. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, vol. 50, pp. 165-174, ISSN:0022-2828 DOI

Scellini B.; Lundy S.; Piroddi N.; Flint G.; Tu A.; Luo Z.; Gordon AM; Regnier M.; Poggesi C.; Tesi C (2011). Role of tropomyosin (Tm) isoforms in skeletal muscle thin filament regulation. JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, vol. 32, pp. 112-113, ISSN:0142-4319

Raffaele Coppini; Cecilia Ferrantini; Claudia Ferrara; Beatrice Scellini; Francesca Stillitano; Chiara Tesi; Elisabetta Cerbai; Silvia Priori; Corrado Poggesi (2011). Impact of R4496C RyR2 mutation on myocardial contractility. BIOPHYSICAL JOURNAL, vol. 100(3), pp. 291a-291a, ISSN:0006-3495

Claudia Ferrara; Nicoletta Piroddi; Beatrice Scellini; Cecilia Ferrantini; Sabine J. van Dijk; Cris dos Remedios; Chiara Tesi; Jolanda van der Velden; Corrado Poggesi (2011). The HCM-Associated Cardiac Troponin T Mutation K273N Accelerates Tension Generation and Relaxation in Human Cardiac Myofibrils. BIOPHYSICAL JOURNAL, vol. 100(3), pp. 115a-115a, ISSN:0006-3495

Ferrantini C.; Belus A.; Piroddi N.; Ferrara C.; Scellini B.; Tesi C.; Cecchi F.; Olivotto I.; Poggesi C. (2011). Age-related decline in contractile function of ventricular myofibrils from HCM patients carrying MYBPC3 mutations. JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, vol. 32, pp. 142-142, ISSN:0142-4319

Passarelli C.; Di Venere A.; Piroddi N.; Pastore A.; Scellini B.; Tesi C.; Petrini S.; Sale P.; Bertini E.; Poggesi C.; Piemonte F. (2010). Susceptibility of isolated myofibrils to in vitro glutathionylation: potential relevance to muscle functions. CYTOSKELETON, vol. 67, pp. 81-89, ISSN:1949-3584 DOI

Piroddi N.; Kreutziger KL.; Scellini B.; Lundy S.; Ferrantini C.; Tesi C.; Regnier M.; Poggesi C. (2010). Effect of troponin Ca2+ binding properties on the kinetics of myofibril force initiation and relaxation. BIOPHYSICAL JOURNAL, vol. 98(3) suppl 1, pp. 415a-415a, ISSN:0006-3495

A. Belus; N. Piroddi; C. Ferrantini; C. Tesi; O. Cazorla; L. Toniolo; M. Drost; G. Mearini; L. Carrier; A. Rossi; A. Mugelli; E. Cerbai; J. van der Velden; C. Poggesi (2010). EFFECTS OF CHRONIC ATRIAL FIBRILLATION ON ACTIVE AND PASSIVE FORCE GENERATION IN HUMAN ATRIAL MYOFIBRILS. CIRCULATION RESEARCH, vol. 107, pp. 144-152, ISSN:0009-7330 DOI

Beatrice, Scellini ; Nicoletta, Piroddi; Corrado, Poggesi; Chiara Tesi (2010). Extraction and Replacement of the Tropomyosin-Troponin Complex in Isolated Myofibrils.. In: Dilson E. Rassier. Muscle Biophysics, pp. 163-174 Dilson E. Rassier, ISBN:978-1-4419-6366-6. DOI

Biesiadecki B.; Alves ML.; Jagatheesan G.; Liu B.; Scellini B.; Tesi C.; Davis JP.; Poggesi C.; Wieczorek DF.; Wolska BM.; Solaro RJ. (2010). Tropomyosin pseudo-phosphorylation and muscle kinetics. BIOPHYSICAL JOURNAL, vol. 98(3), pp. 350a-350a, ISSN:0006-3495

Scellini B.; Piroddi N.; Poggesi C.; Tesi C (2009). Effect of removal and reconstitution of troponin and tropomyosin on Ca2+- activated tension generation in isolated myofibrils. In: società italiana di fisiologia, siena, 23-25 sept., 60° congresso nazionale SIF, vol. 197 (suppl. 672), pp. 24-24.

C. Ferrantini; A. Belus; N. Piroddi; B. Scellini; C. Tesi; C. Poggesi (2009). Mechanical and Energetic Consequences of HCM-Causing Mutations. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, vol. 2, pp. 441-451, ISSN:1937-5387 DOI

I. Olivotto; F. Cecchi; C. Poggesi; M. Yacoub (2009). Developmental origins of hypertrophic cardiomyopathy phenotypes: a unifying hypothesis.. NATURE REVIEWS. CARDIOLOGY, vol. 6, pp. 317-321, ISSN:1759-5002

Ferrantini C.; Coppini R.; Scellini B.; Belus A.; Tesi C.; Colombi B.; Cerbai E.; Napolitano C.; Priori S.; Poggesi C. (2009). Impact of RyR2 mutation responsible for Cathecolaminergic Polymorphic Ventricular Tachycardia (CPTV) on the short term interval-force relationship of atrial and ventricular myocardium. BIOPHYSICAL JOURNAL, vol. 93(3), pp. 111a-111a, ISSN:0006-3495

Matsumoto F.; Piroddi N.; Belus A.; Scellini B.; Maeda K.; Tesi C.; Maeda Y.; Fujiwara S.; Poggesi C. (2009). Functional impact of TnT mutations responsible for Hypertrophic Cardiomyopathy on Tn-exchanged single myofibrils. BIOPHYSICAL JOURNAL, vol. 96(3), pp. 227a-227a, ISSN:0006-3495

Scellini B.; Piroddi N.; Poggesi C.; Tesi C. (2009). Effects of removal and reconstitution of troponin and tropomyosin on Ca2+-activated tension generation in cardiac myofibrils. BIOPHYSICAL JOURNAL, vol. 96(3) suppl, pp. 228a-228a, ISSN:0006-3495

R. STEHLE; J. SOLZIN; B. IORGA; C. POGGESI (2009). Insights into the kinetics of Ca(2+)-regulated contraction and relaxation from myofibril studies.. PFLÜGERS ARCHIV, vol. 458, pp. 337-357, ISSN:0031-6768

Kreutziger, K. L.; Piroddi, Nicoletta; Scellini, Beatrice; Tesi, Chiara; Poggesi, Corrado; Regnier, M. (2008). Thin filament Ca2+ binding properties and regulatory unit interactions alter kinetics of tension development and relaxation in rabbit skeletal muscle. THE JOURNAL OF PHYSIOLOGY, vol. 586, pp. 3683-3700, ISSN:0022-3751 DOI

Belus, ALEXANDRA ANNA SOPHIE; Piroddi, Nicoletta; Scellini, Beatrice; Tesi, Chiara; D'Amati, G.; Girolami, F.; Yacoub, Magdi; Cecchi, Franco; Olivotto, I.; Poggesi, Corrado (2008). The familial hypertrophic cardiomyopathy-associated myosin mutation R403Q accelerates tension generation and relaxation of human cardiac myofibrils. THE JOURNAL OF PHYSIOLOGY, vol. 586, pp. 3639-3644, ISSN:0022-3751 DOI

I. OLIVOTTO; F. GIROLAMI; M.J. ACKERMAN; S. NISTRI; J.M. BOS; E. ZACHARA; S.R. OMMEN; J.L. THEIS; R.A. VAUBEL; F. RE; C. ARMENTANO; C. POGGESI; F. TORRICELLI; F. CECCHI (2008). Myofilament protein gene mutation screening and outcome of patients with hypertrophic cardiomyopathy.. MAYO CLINIC PROCEEDINGS, vol. 83, pp. 630-638, ISSN:0025-6196

Belus A.; Piroddi N.; Scellini B.; Tesi C.; Olivotto I.; Girolami F.; Yacoub M.; Cecchi F.; Poggesi C. (2008). Is fast cross-bridge detachment a common feature to MYH7 and MYBP3 FHC-associated mutations in human cardiac myofibrils?. BIOPHYSICAL JOURNAL, vol. 94 (2) suppl, pp. 495-495, ISSN:0006-3495

J.J. RICE; Y. TU; C. POGGESI; P.P. DE TOMBE (2008). Spatially-compressed cardiac myofilament models generate hysteresis that is not found in real muscle. In: PACIFIC SYMPOSIUM ON BIOCOMPUTING, pp. 366-377.

Belus A.; Piroddi N.; Scellini B.; Tesi C.; Ferrantini C.; Girolami F.; Iascone M.; Ferrazzi P.; Yacoub M.; Cecchi F.; Olivotto I.; Poggesi C. (2008). Myosin Binding Protein-C Mutations responsible for Hypertrophic Cardiomyophaty impair relaxation in human cardiac myofibrils. JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, vol. 29, pp. 279-279, ISSN:0142-4319

DE TOMBE, P. P.; Belus, ALEXANDRA ANNA SOPHIE; Piroddi, Nicoletta; Scellini, Beatrice; Walker, J. S.; Martin, A. F.; Tesi, Chiara; Poggesi, Corrado (2007). Myofilament calcium sensitivity does not affect cross-bridge activation-relaxation kinetics. AMERICAN JOURNAL OF PHYSIOLOGY, vol. 292, pp. R1129-R1136, ISSN:0002-9513 DOI

N.PIRODDI; A.BELUS; B.SCELLINI; C.TESI; G.GIUNTI; E. CERBAI; A.MUGELLI; C.POGGESI (2007). Tension generation and relaxation in single myofibrils from human atrial and ventricular myocardium.. PFLÜGERS ARCHIV, vol. 454, pp. 63-73, ISSN:0031-6768 DOI

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N.PIRODDI; A.BELUS; S.EIRAS; C.TESI; J.VAN DER VELDEN; C.POGGESI; G.J.STIENEN (2006). No direct effect of creatine phosphate on the cross-bridge cycle in cardiac myofibrils. PFLÜGERS ARCHIV, vol. 452, pp. 3-6, ISSN:0031-6768 DOI

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C. POGGESI; C. RUSCONI (2004). PHYSIOLOGICAL DETERMINANTS OF LEFT VENTRICULAR RELAXATION AND PRESSURE FALL. In: C. RUSCONI, O.M. HESS, C. POGGESI. LEFT VENTRICULAR DIASTOLIC FUNCTION , DYSFUNCTION, AND FAILURE: A COMPREHENSIVE TEXTBOOK, pp. 121-160, Roma: C.E.S.I. PUBLISHER, ISBN:9788886062893.

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N.PIRODDI; C.TESI; M.A.PELLEGRINO; L.S.TOBACMAN; E.HOMSHER; C.POGGESI (2003). Contractile effects of the exchange of cardiac troponin for fast skeletal troponin in rabbit psoas single myofibrils. THE JOURNAL OF PHYSIOLOGY, vol. 552, pp. 917-931, ISSN:0022-3751 DOI

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V.COMINCIOLI; A.TORELLI; C.POGGESI; C.REGGIANI (1984). A four-state cross bridge model for muscle contraction. Mathematical study and validation. JOURNAL OF MATHEMATICAL BIOLOGY, vol. 20, pp. 277-304, ISSN:0303-6812

C.POGGESI; C.REGGIANI; R.BOTTINELLI; L.RICCIARDI; R.MINELLI (1983). Relaxation in atrial and ventricular myocardium: activation decay and different load sensitivity. BASIC RESEARCH IN CARDIOLOGY, vol. 78, pp. 256-265, ISSN:0300-8428

C.POGGESI; C.REGGIANI; L.RICCIARDI; R.MINELLI (1982). Factors modulating the sensitivity of the relaxation to the loading conditions in rat cardiac muscle. PFLÜGERS ARCHIV, vol. 394, pp. 338-346, ISSN:0031-6768

R.BOTTINELLI; C.POGGESI; L.RICCIARDI; R.MINELLI (1982). The influence of temperature on the relaxation properties of rat papillary muscle. BOLLETTINO DELLA SOCIETA' ITALIANA DI BIOLOGIA SPERIMENTALE, vol. 58, pp. 177-183, ISSN:0037-8771

C.POGGESI; C.REGGIANI (1982). Comments on "Relaxation properties of mammalian atrial muscle" which appeared in Circ. Res. 48: 352-356, 1981. CIRCULATION RESEARCH, vol. 50, pp. 440-441, ISSN:0009-7330

R.BOTTINELLI; C.POGGESI; L.RICCIARDI; C.REGGIANI (1982). Effect of muscle stretch during isometric contraction on the time-course or relaxation in mammalian myocardium. BOLLETTINO DELLA SOCIETA' ITALIANA DI BIOLOGIA SPERIMENTALE, vol. 58, pp. 184-190, ISSN:0037-8771

V.CAPPELLI; C.REGGIANI; C.POGGESI; L.RICCIARDI (1982). Inulin uptake and washout in contracting and quiescent rat papillary muscle. ARCHIVES INTERNATIONALES DE PHYSIOLOGIE ET DE BIOCHIMIE, vol. 90, pp. 231-236, ISSN:0003-9799

V.CAPPELLI; C.POGGESI; L.RICCIARDI; C.REGGIANI (1981). Tritiated water (HTO) and inulin spaces in isolated skeletal and cardiac muscles: influence of contractile activity. EXPERIENTIA, vol. 37, pp. 849-850, ISSN:0014-4754

A.CAPELO; V.COMINCIOLI; R.MINELLI; C.POGGESI; C.REGGIANI; L.RICCIARDI (1981). Study and parameters identification of a rheological model for excised quiescent cardiac muscle. JOURNAL OF BIOMECHANICS, vol. 14, pp. 1-11, ISSN:0021-9290

C. POGGESI; L. RICCIARDI; C. REGGIANI; R. MINELLI (1980). The variation in tension output with active shortening in rat myocardium.. ARCHIVES ITALIENNES DE BIOLOGIE, vol. 118, pp. 346-357, ISSN:0003-9829

C. REGGIANI; C. POGGESI; L. RICCIARDI; R. MINELLI (1980). Time course and duration of the depressant effect of active shortening in cardiac muscle.. PFLÜGERS ARCHIV, vol. 385, pp. 273-276, ISSN:0031-6768

C. POGGESI; L. RICCIARDI; C. REGGIANI; V. BASILICO; R. MINELLI (1979). Visco-elastic characteristics of the rat aorta. BOLLETTINO DELLA SOCIETA' ITALIANA DI BIOLOGIA SPERIMENTALE, vol. 55, pp. 1753-1758, ISSN:0037-8771

C. REGGIANI; C. POGGESI; R. MINELLI (1979). The analysis of some mechanical properties of quiescent myocardium.. JOURNAL OF BIOMECHANICS, vol. 12, pp. 173-182, ISSN:0021-9290

C. POGGESI; L. RICCIARDI; C. REGGIANI; R. MINELLI (1979). Isometric relaxation in rat myocardium: load dependence and influence of caffeine.. EXPERIENTIA, vol. 35, pp. 1615-1617, ISSN:0014-4754

C. POGGESI; L. RICCIARDI; C. REGGIANI; R. MINELLI (1978). The effect of some inotropic interventions on shortening deactivation in rat papillary muscle.. BOLLETTINO DELLA SOCIETA' ITALIANA DI BIOLOGIA SPERIMENTALE, vol. 54, pp. 1956-1962, ISSN:0037-8771

C. Reggiani; L. Ricciardi; C. Poggesi; R. Minelli (1978). Influence of internal shortening on time course of active state in rat papillary muscle.. ARCHIVES ITALIENNES DE BIOLOGIE, vol. 116, pp. 43-52, ISSN:0003-9829

Corrado POGGESI

Biography

Born in Brescia, Italy, on October 14 1950. MD cum laude in Pavia 1975 (alumnus of Collegio Ghislieri).

Since 2021 Emeritus Professor of Physiology at the University of Florence, Florence, Italy

Academic career at the School of Medicine of the University of Pavia (1975-1987) and the University of Florence (1987-2020). Full professor of Physiology sincel 1994.

Institutional activity

Currently, member designed by the Ministery of University & Research (MUR) of the Board of the National Institute of Cardiovascular Research (INRC).

2013-2020 Head of the Department of Experimental and Clinical Medicine (University of Florence).

2018-2020 President of the Italian Physiological Society

2018-2021 President of the National Commitee for professorship habilitation in Physiology.

2008-2012 Member of the Academic Senate of the University of Florence.

2008-2011 Member of the Board of the Italian Physiological Society.

2006-2008 Head of the Department of Physiological Sciences.

2000-2010 Coordinator of the PhD School in Physiological and Nutritional Sciences, University of Florence.

Editorial activity

Senior Consultant Editor of the Journal of Molecular and Cellular Cardiology; Associate Editor of Frontiers in Physiology: Striated Muscle Physiology; Past Member of the Editorial Board of the Journal of Cardiovascular Translational Research (2010-2023); Editor of a special issue of the Journal of Muscle Research and Cell Motility (2023-2024); Reviewer activity for a large number of scientific journals and International Granting Agencies.

Research experience abroad

1985-1987 Senior research fellow at the Department of Pharmacology, Mayo Clinic (Rochester, MN, USA). 2003 Visiting Scientist, Department of Physiology & Biophysics, UCLA (Los Angeles, CA, USA).

Short research visits at INSERM CNRS Montpellier; Columbia University, New York; University of Washington, Seattle; University of Illinois, Chicago; Loyola University, Chicago.

Research Grants

Awarded with several grants from the European Union, Italian Ministery of University, Telethon.

Still collaborating to the following EU grants:

• EU Horizon-HLTH-2023-Tool-05-03: project SMASH-HCM GA n. 101137115: Stratification, Management, and Guidance of Hypertrophic Cardiomyopathy Patients using Hybrid Digital Twin Solutions. 2023-2026.

• EU Horizon 2020 Future and Emerging Technologies: project REPAIR GA n. 952166 Restoring Cardiac Mechanical Function by Polymeric Artificial Muscular Tissue 2020-2025.

Dr Poggesi research activity is related to biophysical aspects of the contractile mechanism in skeletal and cardiac muscle (Excitation-Contraction Coupling, Contraction regulation and Chemo-Mechanical transduction). Micromechanics and microperfusion techniques have been developed in his lab to measure sarcomere mechanics in single myofibrils isolated from cardiac and skeletal muscle from human and animal models. These techniques have been also succesfully applied to investigate genetic myopathies and cardiomyopathies. These myofibril techniques have been fully or partly reproduced in several international laboratories. Dr Poggesi has recently contributed, in collaboration with investigators working at CNR facilities, to the development of novel optical techniques to investigate arrhythmogenic mechanisms and E-C coupling in cardiac muscle. He is author of more than 135 scientific papers with more than 5000 quotations and an h index of 44 (WOS).