Personale

Recapiti

Italiano

Pubblicazioni

Insegnamenti

English

Curriculum

Romina NASSINI

Ruolo attuale:: Professore Ordinario
SSD:: BIOS-11/A - Farmacologia
Afferenza organizzativa:: Dipartimento di Scienze della Salute (DSS)

Recapiti

	0552758130
	romina.nassini(AT)unifi.it

Romina NASSINI

Pubblicazioni

Legenda

Contributo su rivista |

Articolo su libro |

Libro |

Contributo in atti di convegno (proceeding) |

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Curatela | Altro

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Tesi di Dottorato

Catalano, Martina; Nozzoli, Filippo; De Logu, Francesco; Nassini, Romina; Roviello, Giandomenico (2024). Management Approaches for High-Risk Cutaneous Squamous Cell Carcinoma with Perineural Invasion: An Updated Review. CURRENT TREATMENT OPTIONS IN ONCOLOGY, vol. -, pp. 1-9, ISSN:1527-2729 DOI

Nozzoli, Filippo; Nassini, Romina; De Logu, Francesco; Catalano, Martina; Roviello, Giandomenico; Massi, Daniela (2024). Reconceiving Perineural Invasion in Cutaneous Squamous Cell Carcinoma: From Biological to Histopathological Assessment. PATHOBIOLOGY, vol. -, pp. 1-13, ISSN:1015-2008 DOI

Francesca Bandinelli, Romina Nassini, Eleonora Gherardi, Barbara Chiocchetti, Mirko Manetti, Massimo Cincotta, Filippo Nozzoli, Elena Nucci, Francesco De Logu, Nicola Pimpinelli (2024). Small Fiber Neuropathy Associated with Post-COVID-19 and Post-COVID-19 Vaccination Arthritis: A Rare Post-Infective Syndrome or a New-Onset Disease?. JOURNAL OF PERSONALIZED MEDICINE, vol. 14, pp. 789-789, ISSN:2075-4426 DOI Accesso ONLINE all'editore

Titiz, Mustafa; Landini, Lorenzo; Souza Monteiro de Araujo, Daniel; Marini, Matilde; Seravalli, Viola; Chieca, Martina; Pensieri, Pasquale; Montini, Marco; De Siena, Gaetano; Pasquini, Benedetta; Vannuccini, Silvia; Iannone, Luigi Francesco; Cunha, Thiago M.; Brancolini, Giulia; Bellantoni, Elisa; Scuffi, Irene; Mastricci, Alessandra; Tesi, Martina; Di Tommaso, Mariarosaria; Petraglia, Felice; Geppetti, Pierangelo; Nassini, Romina; De Logu, Francesco (2024). Schwann cell C5aR1 co-opts inflammasome NLRP1 to sustain pain in a mouse model of endometriosis. NATURE COMMUNICATIONS, vol. 15, pp. 0-0, ISSN:2041-1723 DOI

Nozzoli, Filippo; Catalano, Martina; Messerini, Luca; Cianchi, Fabio; Nassini, Romina; De Logu, Francesco; Iannone, Luigi Francesco; Ugolini, Filippo; Simi, Sara; Massi, Daniela; Geppetti, Pierangelo; Roviello, Giandomenico (2024). Perineural invasion score system and clinical outcomes in resected pancreatic cancer patients. PANCREATOLOGY, vol. -, pp. 1-9, ISSN:1424-3903 DOI

Latini, Laura; De Araujo, Daniel Souza Monteiro; Amato, Rosario; Canovai, Alessio; Buccarello, Lucia; De Logu, Francesco; Novelli, Elena; Vlasiuk, Anastasiia; Malerba, Francesca; Arisi, Ivan; Florio, Rita; Asari, Hiroki; Capsoni, Simona; Strettoi, Enrica; Villetti, Gino; Imbimbo, Bruno Pietro; Dal Monte, Massimo; Nassini, Romina; Geppetti, Pierangelo; Marinelli, Silvia; Cattaneo, Antonino (2024). A p75 neurotrophin receptor‐sparing nerve growth factor protects retinal ganglion cells from neurodegeneration by targeting microglia. BRITISH JOURNAL OF PHARMACOLOGY, vol. 181, pp. 4890-4919, ISSN:0007-1188 DOI

Bellantoni, Elisa; Marini, Matilde; Chieca, Martina; Gabellini, Chiara; Crapanzano, Erica Lucia; Souza Monteiro de Araujo, Daniel; Nosi, Daniele; Roschi, Lorenzo; Landini, Lorenzo; De Siena, Gaetano; Pensieri, Pasquale; Mastricci, Alessandra; Scuffi, Irene; Geppetti, Pierangelo; Nassini, Romina; De Logu, Francesco (2024). Schwann cell transient receptor potential ankyrin 1 (TRPA1) ortholog in zebrafish larvae mediates chemotherapy‐induced peripheral neuropathy. BRITISH JOURNAL OF PHARMACOLOGY, vol. 181, pp. 4859-4873, ISSN:0007-1188 DOI

Brum, Evelyne Silva; Fialho, Maria Fernanda Pessano; Souza Monteiro de Araújo, Daniel; Landini, Lorenzo; Marini, Matilde; Titiz, Mustafa; Kuhn, Bruna Luiza; Frizzo, Clarissa Piccinin; Araújo, Pedro Henrique Silva; Guimarães, Rafaela Mano; Cunha, Thiago Mattar; Silva, Cássia Regina; Trevisan, Gabriela; Geppetti, Pierangelo; Nassini, Romina; De Logu, Francesco; Oliveira, Sara Marchesan (2024). Schwann cell TRPA1 elicits reserpine‐induced fibromyalgia pain in mice. BRITISH JOURNAL OF PHARMACOLOGY, vol. 181, pp. 3445-3461, ISSN:0007-1188 DOI

Nascimento, Thaianne Hanah Oliveira do; Pereira-Figueiredo, Danniel; Veroneze, Louise; Nascimento, Amanda Alves; De Logu, Francesco; Nassini, Romina; Campello-Costa, Paula; Faria-Melibeu, Adriana da Cunha; Souza Monteiro de Araújo, Daniel; Calaza, Karin Costa (2024). Functions of TRPs in retinal tissue in physiological and pathological conditions. FRONTIERS IN MOLECULAR NEUROSCIENCE, vol. 17, pp. 0-0, ISSN:1662-5099 DOI

Mattei, Gianluca; Baragli, Marta; Gega, Barbara; Mingrino, Alessandra; Chieca, Martina; Ducci, Tommaso; Frigè, Gianmaria; Mazzarella, Luca; D'Aurizio, Romina; De Logu, Francesco; Nassini, Romina; Pelicci, Pier Giuseppe; Magi, Alberto (2024). PoreMeth2: decoding the evolution of methylome alterations with Nanopore sequencing. DOI

Landini, Lorenzo; Marini, Matilde; Souza Monteiro de Araujo, Daniel; Romitelli, Antonia; Montini, Marco; Albanese, Valentina; Titiz, Mustafa; Innocenti, Alessandro; Bianchini, Francesca; Geppetti, Pierangelo; Nassini, Romina; De Logu, Francesco (2023). Schwann cell insulin-like growth factor receptor type-1 mediates metastatic bone cancer pain in mice. BRAIN, BEHAVIOR, AND IMMUNITY, vol. 110, pp. 348-364, ISSN:1090-2139 DOI

De Logu, Francesco; De Siena, Gaetano; Landini, Lorenzo; Marini, Matilde; Souza Monteiro de Araujo, Daniel; Albanese, Valentina; Preti, Delia; Romitelli, Antonia; Chieca, Martina; Titiz, Mustafa; Iannone, Luigi F; Geppetti, Pierangelo; Nassini, Romina (2023). Non-neuronal TRPA1 encodes mechanical allodynia associated with neurogenic inflammation and partial nerve injury in rats. BRITISH JOURNAL OF PHARMACOLOGY, vol. 180, pp. 1232-1246, ISSN:1476-5381 DOI

Landini, Lorenzo; Souza Monteiro de Araujo, Daniel; Chieca, Martina; De Siena, Gaetano; Bellantoni, Elisa; Geppetti, Pierangelo; Nassini, Romina; De Logu, Francesco (2023). Acetaldehyde via CGRP receptor and TRPA1 in Schwann cells mediates ethanol-evoked periorbital mechanical allodynia in mice: relevance for migraine. JOURNAL OF BIOMEDICAL SCIENCE, vol. 30, pp. 28-34, ISSN:1423-0127 DOI

Dalenogare, Diéssica Padilha; Souza Monteiro de Araújo, Daniel; Landini, Lorenzo; Titiz, Mustafa; De Siena, Gaetano; De Logu, Francesco; Geppetti, Pierangelo; Nassini, Romina; Trevisan, Gabriela (2023). Neuropathic-like Nociception and Spinal Cord Neuroinflammation Are Dependent on the TRPA1 Channel in Multiple Sclerosis Models in Mice. CELLS, vol. 12, pp. 0-0, ISSN:2073-4409 DOI

Marini, Matilde; Titiz, Mustafa; Souza Monteiro de Araújo, Daniel; Geppetti, Pierangelo; Nassini, Romina; De Logu, Francesco (2023). TRP Channels in Cancer: Signaling Mechanisms and Translational Approaches. BIOMOLECULES, vol. 13, pp. 0-0, ISSN:2218-273X DOI

Iannone L.F.; Nassini R.; Patacchini R.; Geppetti P.; De Logu F. (2022). Neuronal and non-neuronal TRPA1 as therapeutic targets for pain and headache relief. TEMPERATURE, pp. 1-17, ISSN:2332-8940 DOI

Souza Monteiro de Araújo, Daniel; Brito, Rafael; Pereira-Figueiredo, Danniel; Dos Santos-Rodrigues, Alexandre; De Logu, Francesco; Nassini, Romina; Zin, Andrea; Calaza, Karin C (2022). Retinal Toxicity Induced by Chemical Agents. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, pp. 8182-8210, ISSN:1422-0067 DOI

Viero, Fernanda Tibolla; Rodrigues, Patrícia; Frare, Julia Maria; Da Silva, Náthaly Andrighetto Ruviaro; Ferreira, Marcella de Amorim; Da Silva, Ana Merian; Pereira, Gabriele Cheiran; Ferreira, Juliano; Pillat, Micheli Mainardi; Bocchi, Guilherme Vargas; Nassini, Romina; Geppetti, Pierangelo; Trevisan, Gabriela (2022). Unpredictable Sound Stress Model Causes Migraine-Like Behaviors in Mice With Sexual Dimorphism. FRONTIERS IN PHARMACOLOGY, vol. 13, pp. 911105-911105, ISSN:1663-9812 DOI

Hurdogan, Ozge; De Logu, Francesco; Galli, Francesca; Tuncer, Samuray; Ugolini, Filippo; Simi, Sara; Portelli, Francesca; Nassini, Romina; Massi, Daniela; Buyukbabani, Nesimi (2022). Digital Quantification of Intratumoral CD8+ T-Cells Predicts Relapse and Unfavorable Outcome in Uveal Melanoma. CANCERS, vol. 14, pp. 0-0, ISSN:2072-6694 DOI

Ugolini, Filippo; Baroni, Gianna; Nassini, Romina; De Logu, Francesco; Massi, Daniela (2022). A Fast and Automated Melanin-bleaching Method for Histopathologic Evaluation of Pigmented Melanoma Tissues. APPLIED IMMUNOHISTOCHEMISTRY AND MOLECULAR MORPHOLOGY, vol. 30, pp. 311-316, ISSN:1541-2016 DOI

De Logu, Francesco; Maglie, Roberto; Titiz, Mustafa; Poli, Giulio; Landini, Lorenzo; Marini, Matilde; Monteiro de Araujo, Daniel Souza; De Siena, Gaetano; Montini, Marco; Cabrini, Daniela Almeida; Otuki, Michel Fleith; Pawloski, Priscila Lúcia; Antiga, Emiliano; Tuccinardi, Tiziano; Calixto, João Batista; Geppetti, Pierangelo; Nassini, Romina; André, Eunice (2022). miRNA-203b-3p induces acute and chronic pruritus via 5-HTR2B and TRPV4. JOURNAL OF INVESTIGATIVE DERMATOLOGY, pp. 0-0, ISSN:0022-202X DOI

De Logu F.; Nassini R.; Hegron A.; Landini L.; Jensen D.D.; Latorre R.; Ding J.; Marini M.; Souza Monteiro de Araujo D.; Ramirez-Garcia P.; Whittaker M.; Retamal J.; Titiz M.; Innocenti A.; Davis T.P.; Veldhuis N.; Schmidt B.L.; Bunnett N.W.; Geppetti P. (2022). Schwann cell endosome CGRP signals elicit periorbital mechanical allodynia in mice. NATURE COMMUNICATIONS, vol. 13, pp. 0-0, ISSN:2041-1723 DOI

Audrito V., Moiso E., Ugolini F., Messana V.G., Brandimarte L., Manfredonia I., Bianchi S., De Logu F., Nassini R., Szumera-Ciećkiewicz A., Taverna D., Massi D. (2022). Tumors carrying BRAF-mutations over-express NAMPT that is genetically amplified and possesses oncogenic properties. JOURNAL OF TRANSLATIONAL MEDICINE, pp. 0-0, ISSN:1479-5876 DOI

Maglie R.; Ugolini F.; De Logu F.; Nassini R.; Simi S.; Nardiello P.; Pasqualini E.; Baroni G.; Del Bianco E.; Massi D.; Antiga E. (2022). Overexpression of helper T cell type 2-related molecules in the skin of patients with eosinophilic dermatosis of hematologic malignancy. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, pp. .-., ISSN:0190-9622 DOI

Dalenogare, Diéssica P; Theisen, Maria C; Peres, Diulle S; Fialho, Maria F P; Andrighetto, Nathaly; Barros, Laura; Landini, Lorenzo; Titiz, Mustafa; De Logu, Francesco; Oliveira, Sara M; Geppetti, Pierangelo; Nassini, Romina; Trevisan, Gabriela (2021). Transient receptor potential ankyrin 1 mediates headache-related cephalic allodynia in a mouse model of relapsing-remitting multiple sclerosis. PAIN, vol. Publish Ahead of Print, pp. 0-0, ISSN:0304-3959 DOI

De Logu F.; Galli F.; Nassini R.; Ugolini F.; Simi S.; Cossa M.; Miracco C.; Gianatti A.; De Giorgi V.; Rulli E.; Cossu A.; Massi D.; Mandala M. (2021). Digital immunophenotyping predicts disease free and overall survival in early stage melanoma patients. CELLS, vol. 10, pp. 1-20, ISSN:2073-4409 DOI

Maglie R.; Ugolini F.; De Logu F.; Simi S.; Senatore S.; Montefusco F.; Nassini R.; Massi D.; Antiga E. (2021). Dupilumab for the treatment of recalcitrant eosinophilic dermatosis of haematologic malignancy. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, vol. 35, pp. e501-e503, ISSN:0926-9959 DOI

Dalenogare D.P.; Ritter C.; Bellinaso F.R.A.; Kudsi S.Q.; Pereira G.C.; Fialho M.F.P.; Luckemeyer D.D.; Antoniazzi C.T.D.; Landini L.; Ferreira J.; Bochi G.V.; Oliveira S.M.; De Logu F.; Nassini R.; Geppetti P.; Trevisan G. (2021). Periorbital nociception in a progressive multiple sclerosis mouse model is dependent on trpa1 channel activation. PHARMACEUTICALS, vol. 14, pp. 0-0, ISSN:1424-8247 DOI

Bruno G.; De Logu F.; Souza Monteiro de Araujo D.; Subbiani A.; Lunardi F.; Rettori S.; Nassini R.; Favre C.; Calvani M. (2021). β2-and β3-Adrenergic Receptors Contribute to Cancer-Evoked Pain in a Mouse Model of Osteosarcoma via Modulation of Neural Macrophages. FRONTIERS IN PHARMACOLOGY, vol. 12, pp. 0-0, ISSN:1663-9812 DOI

De Logu F.; de Araujo D.S.M.; Ugolini F.; Iannone L.F.; Vannucchi M.; Portelli F.; Landini L.; Titiz M.; De Giorgi V.; Geppetti P.; Massi D.; Nassini R. (2021). The trpa1 channel amplifies the oxidative stress signal in melanoma. CELLS, vol. 10, pp. 0-0, ISSN:2073-4409 DOI

de Logu F.; Marini M.; Landini L.; de Araujo D.S.M.; Bartalucci N.; Trevisan G.; Bruno G.; Marangoni M.; Schmidt B.L.; Bunnett N.W.; Geppetti P.; Nassini R. (2021). Peripheral nerve resident macrophages and schwann cells mediate cancer-induced pain A C. CANCER RESEARCH, vol. 81, pp. 3387-3401, ISSN:0008-5472 DOI

Maglie R.; de Araujo D.S.M.; Antiga E.; Geppetti P.; Nassini R.; De Logu F. (2021). The role of trpa1 in skin physiology and pathology. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, pp. 1-13, ISSN:1661-6596 DOI

De Logu F.; Trevisan G.; Marone I.M.; Coppi E.; Padilha Dalenogare D.; Titiz M.; Marini M.; Landini L.; Souza Monteiro de Araujo D.; Li Puma S.; Materazzi S.; De Siena G.; Geppetti P.; Nassini R. (2020). Oxidative stress mediates thalidomide-induced pain by targeting peripheral TRPA1 and central TRPV4. BMC BIOLOGY, vol. 18, pp. 197-197, ISSN:1741-7007 DOI

de Logu, Francesco; Dal-Toé De Prá, Samira; Tatiane de David Antoniazzi, Caren; Qader Kudsi, Sabrina; Ronsani Ferro, Paula; Landini, Lorenzo; Karine Rigo, Flávia; de Bem Silveira, Gustavo; Cesar Lock Silveira, Paulo; Marchesan Oliveira, Sara; Marini, Matilde; Mattei, Gianluca; Ferreira, Juliano; Geppetti, Pierangelo; Nassini, Romina; Trevisan, Gabriela (2020). Macrophages and Schwann cell TRPA1 mediate chronic allodynia in a mouse model of complex regional pain syndrome type I. BRAIN BEHAVIOR AND IMMUNITY, pp. ---, ISSN:0889-1591 DOI

Souza Monteiro de Araujo D.; Nassini R.; Geppetti P.; De Logu F. (2020). TRPA1 as a therapeutic target for nociceptive pain. EXPERT OPINION ON THERAPEUTIC TARGETS, pp. 1-12-12, ISSN:1472-8222 DOI

Francesco De Logu, Filippo Ugolini, Vincenza Maio, Sara Simi, Antonio Cossu, Daniela Massi, Italian Association for Cancer Research (AIRC) Study Group, Romina Nassini, Marco Laurino (2020). Recognition of Cutaneous Melanoma on Digitized Histopathological Slides via Artificial Intelligence Algorithm. FRONTIERS IN ONCOLOGY, pp. 0-0, ISSN:2234-943X DOI

De Logu F.; Ugolini F.; Caporalini C.; Palomba A.; Simi S.; Portelli F.; Campanacci D.A.; Beltrami G.; Massi D.; Nassini R. (2020). Trpa1 expression in synovial sarcoma may support neural origin. BIOMOLECULES, vol. 10, pp. 1-13, ISSN:2218-273X DOI

Novelli D.; Fumagalli F.; Staszewsky L.; Ristagno G.; Olivari D.; Masson S.; De Giorgio D.; Ceriani S.; Massafra R.; De Logu F.; Nassini R.; Milioli M.; Facchinetti F.; Cantoni S.; Trevisani M.; Letizia T.; Russo I.; Salio M.; Latini R. (2020). Primary pulmonary arterial hypertension: Protocol to assess comprehensively in the rat the response to pharmacologic treatments. METHODSX (AMSTERDAM), vol. 7, pp. 100771-100771, ISSN:2215-0161 DOI

1. Jain P., Materazzi S., De Logu F., Rossi Degl’Innocenti D., Fusi C., Li Puma S., Marone I. M., Coppi E., Holzer P., Geppetti P., and Nassini R. (2020). Transient receptor potential ankyrin 1 contributes to somatic pain hypersensitivity in experimental colitis. SCIENTIFIC REPORTS, pp. 0-0, ISSN:2045-2322 DOI

Souza Monteiro de Araujo D.; De Logu F.; Adembri C.; Rizzo S.; Janal M.N.; Landini L.; Magi A.; Mattei G.; Cini N.; Pandolfo P.; Geppetti P.; Nassini R.; Calaza K.C. (2020). TRPA1 mediates damage of the retina induced by ischemia and reperfusion in mice. CELL DEATH & DISEASE, vol. 11, pp. 0-0, ISSN:2041-4889 DOI

Calvani, Maura; Bruno, Gennaro; Dal Monte, Massimo; Nassini, Romina; Fontani, Filippo; Casini, Arianna; Cavallini, Lorenzo; Becatti, Matteo; Bianchini, Francesca; De Logu, Francesco; Forni, Giulia; la Marca, Giancarlo; Calorini, Lido; Bagnoli, Paola; Chiarugi, Paola; Pupi, Alberto; Azzari, Chiara; Geppetti, Pierangelo; Favre, Claudio; Filippi, Luca (2019). β3-adrenoceptor as a potential immuno-suppressor agent in melanoma. BRITISH JOURNAL OF PHARMACOLOGY, vol. 176, pp. 2509-2524, ISSN:1476-5381 DOI

Brusco, Indiara; Li Puma, Simone; Chiepe, Kelly Braga; da Silva Brum, Evelyne; de David Antoniazzi, Caren Tatiane; de Almeida, Amanda Spring; Camponogara, Camila; Silva, Cássia Regina; De Logu, Francesco; de Andrade, Vanessa Moraes; Ferreira, Juliano; Geppetti, Pierangelo; Nassini, Romina; Oliveira, Sara Marchesan; Trevisan, Gabriela (2019). Dacarbazine alone or associated with melanoma-bearing cancer pain model induces painful hypersensitivity by TRPA1 activation in mice. INTERNATIONAL JOURNAL OF CANCER, pp. 0-0, ISSN:0020-7136 DOI

De Logu, Francesco; Li Puma, Simone; Landini, Lorenzo; Portelli, Francesca; Innocenti, Alessandro; de Araújo, Daniel Souza Monteiro; Janal, Malvin N; Patacchini, Riccardo; Bunnett, Nigel W; Geppetti, Pierangelo; Nassini, Romina (2019). Schwann cells expressing nociceptive channel TRPA1 orchestrate ethanol-evoked neuropathic pain in mice. THE JOURNAL OF CLINICAL INVESTIGATION, pp. 128022-128022, ISSN:1558-8238 DOI

Dallazen J.L.; Maria-Ferreira D.; da Luz B.B.; Nascimento A.M.; Cipriani T.R.; de Souza L.M.; Felipe L.P.G.; Silva B.J.G.; Nassini R.; de Paula Werner M.F. (2019). Pharmacological potential of alkylamides from Acmella oleracea flowers and synthetic isobutylalkyl amide to treat inflammatory pain. INFLAMMOPHARMACOLOGY, pp. ---, ISSN:0925-4692 DOI Accesso ONLINE all'editore

Noroes M.M.; Santos L.G.; Gavioli E.C.; de Paula Soares Rachetti V.; Otuki M.F.; de Almeida Cabrini D.; da Silveira Prudente A.; Oliveira J.R.J.M.; de Carvalho Goncalves M.; Ferreira J.; Preti D.; De Logu F.; Nassini R.; Andre E. (2019). Role of TRPA1 receptors in skin inflammation induced by volatile chemical irritants in mice. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 858, pp. 172460--, ISSN:0014-2999 DOI Accesso ONLINE all'editore

De Logu F, Nassini R, Landini L, Geppetti P (2019). Pathways of CGRP Release from Primary Sensory Neurons.. In: De Logu, F., Nassini, R., Landini, L. and Geppetti, P.. Handbook of Experimental Pharmacology, pp. 65-84 Springer, Cham.

Cantoni S.; Cavalli S.; Pastore F.; Accetta A.; Pala D.; Vaccaro F.; Cesari N.; De Logu F.; Nassini R.; Villetti G.; Facchinetti F. (2019). Pharmacological characterization of a highly selective Rho kinase (ROCK) inhibitor and its therapeutic effects in experimental pulmonary hypertension. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 850, pp. 126-134, ISSN:0014-2999 DOI Accesso ONLINE all'editore

De Logu F.; Landini L.; Janal M.N.; Li Puma S.; De Cesaris F.; Geppetti P.; Nassini R. (2019). Migraine-provoking substances evoke periorbital allodynia in mice. THE JOURNAL OF HEADACHE AND PAIN, vol. 20, pp. 18-18, ISSN:1129-2369 DOI Accesso ONLINE all'editore

Li Puma S.; Landini L.; Macedo S.J.; Seravalli V.; Marone I.M.; Coppi E.; Patacchini R.; Geppetti P.; Materazzi S.; Nassini R.; De Logu F. (2019). TRPA1 mediates the antinociceptive properties of the constituent of Crocus sativus L., safranal. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. 23, pp. 1976-1986, ISSN:1582-1838 DOI Accesso ONLINE all'editore

Massi D.; Rulli E.; Cossa M.; Valeri B.; Rodolfo M.; Merelli B.; De Logu F.; Nassini R.; Del Vecchio M.; Di Guardo L.; De Penni R.; Guida M.; Sileni V.C.; Di Giacomo A.M.; Tucci M.; Occelli M.; Portelli F.; Vallacchi V.; Consoli F.; Quaglino P.; Queirolo P.; Baroni G.; Carnevale-Schianca F.; Cattaneo L.; Minisini A.; Palmieri G.; Rivoltini L.; Mandala M.; Simi S.; Galli F. (2019). The density and spatial tissue distribution of CD8+ and CD163+ immune cells predict response and outcome in melanoma patients receiving MAPK inhibitors. JOURNAL FOR IMMUNOTHERAPY OF CANCER, vol. 7, pp. 308-308, ISSN:2051-1426 DOI

Novelli D.; Fumagalli F.; Staszewsky L.; Ristagno G.; Olivari D.; Masson S.; De Giorgio D.; Ceriani S.; Affatato R.; De Logu F.; Nassini R.; Milioli M.; Facchinetti F.; Cantoni S.; Trevisani M.; Letizia T.; Russo I.; Salio M.; Latini R. (2019). Monocrotaline-induced pulmonary arterial hypertension: Time-course of injury and comparative evaluation of macitentan and Y-27632, a Rho kinase inhibitor. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 865, pp. 0-0, ISSN:0014-2999 DOI

De Logu F.; Li Puma S.; Landini L.; Tuccinardi T.; Poli G.; Preti D.; De Siena G.; Patacchini R.; Tsagareli M.G.; Geppetti P.; Nassini R. (2019). The acyl-glucuronide metabolite of ibuprofen has analgesic and anti-inflammatory effects via the TRPA1 channel. PHARMACOLOGICAL RESEARCH, vol. 142, pp. 127-139, ISSN:1043-6618 DOI Accesso ONLINE all'editore

Antoniazzi, Caren Tatiane De David; Nassini, Romina; Rigo, Flávia Karine; Milioli, Alessandra Marcon; Bellinaso, Fernando; Camponogara, Camila; Silva, Cássia Regina; de Almeida, Amanda Spring; Rossato, Mateus Fortes; De Logu, Francesco; Oliveira, Sara Marchesan; Cunha, Thiago Mattar; Geppetti, Pierangelo; Ferreira, Juliano; Trevisan, Gabriela (2018). Transient receptor potential ankyrin 1 (TRPA1) plays a critical role in a mouse model of cancer pain. INTERNATIONAL JOURNAL OF CANCER, pp. 0-., ISSN:0020-7136 DOI

Marone, IM; De Logu F; Nassini R; De Carvalho Goncalves M, Benemei S, Ferreira J, Piyush J; Li Puma S, Bunnett NW, Geppetti P; Materazzi s (2018). TRPA1/NOX in the soma of trigeminal ganglion neurons mediates migraine-related pain of glyceryl trinitrate in mice. BRAIN, vol. 141, pp. 2312-2328, ISSN:0006-8950 DOI

Boccella, Serena; Guida, Francesca; De Logu, Francesco; De Gregorio, Danilo; Mazzitelli, Mariacristina; Belardo, Carmela; Iannotta, Monica; Serra, Nicola; Nassini, Romina; de Novellis, Vito; Geppetti, Pierangelo; Maione, Sabatino; Luongo, Livio (2018). Ketones and pain: unexplored role of hydroxyl carboxylic acid receptor type 2 in the pathophysiology of neuropathic pain. THE FASEB JOURNAL, pp. fj201801033R-fj201801033R, ISSN:0892-6638 DOI

de David Antoniazzi C.T.; De Pra S.D.-T.; Ferro P.R.; Silva M.A.; Adamante G.; de Almeida A.S.; Camponogara C.; da Silva C.R.; de Bem Silveira G.; Silveira P.C.L.; Oliveira S.M.; Rigo F.K.; De Logu F.; Nassini R.; Trevisan G. (2018). Topical treatment with a transient receptor potential ankyrin 1 (TRPA1) antagonist reduced nociception and inflammation in a thermal lesion model in rats. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 125, pp. 28-38, ISSN:0928-0987 DOI Accesso ONLINE all'editore

Mandalà M, De Logu F, Merelli B, Nassini R, Massi D. (2017). Immunomodulating property of MAPK inhibitors: From translational knowledge to clinical implementation. LABORATORY INVESTIGATION, vol. 97, pp. 166-175, ISSN:0023-6837 DOI Accesso ONLINE all'editore

Tonello R, FusiC, Materazzi S, Marone IM, De Logu F, Benemei S, Gonçalves M, Coppi E, Castro-Junior CJ, Gomez MV, Geppetti P, Ferreira J, Nassini R. (2017). The peptide Phα1β, from spider venom, acts as a TRPA1 channel antagonist with antinociceptive effects in mice. BRITISH JOURNAL OF PHARMACOLOGY, pp. 0-0, ISSN:0007-1188 DOI

Massi D; Romano E, Rulli E, Merelli B; Nassini R, De Logu F, Bieche I, Baroni G; Cattaneo L, Xue G, Mandalà M. (2017). Baseline β-catenin, programmed death-ligand 1 expression and tumour-infiltrating lymphocytes predict response and poor prognosis in BRAF inhibitor-treated melanoma patients. EUROPEAN JOURNAL OF CANCER, vol. 78, pp. 70-81, ISSN:0959-8049 DOI Accesso ONLINE all'editore

De Logu F, Nassini R, Materazzi S, Carvalho Gonçalves M, Nosi D, Rossi Degl'Innocenti D, Marone IM, Ferreira J, Li Puma S, Benemei S, Trevisan G, Souza Monteiro De Araújo D, Patacchini R, Bunnett NW, Geppetti, P. (2017). Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice. NATURE COMMUNICATIONS, vol. 8, pp. 1887-1887, ISSN:2041-1723 DOI Accesso ONLINE all'editore

Audrito V, Serra S, Stingi A, Orso F, Gaudino F, Bologna C, Neri F, Garaffo G, Nassini R, Baroni G, Rulli E, Massi D, Oliviero S, Piva R, Taverna D, Mandalà M, Deaglio S. (2017). PD-L1 up-regulation in melanoma increases disease aggressiveness and is mediated through miR-17-5p. ONCOTARGET, vol. 8, pp. 15894-15911, ISSN:1949-2553 DOI Accesso ONLINE all'editore

Benemei S; De Logu F; Li Puma S; Marone IM; Coppi E; Ugolin F; Liedtke W; Pollastro F; Appendino G; Geppetti P; Materazzi S; Nassini R. (2017). The anti-migraine component of butterbur extracts, isopetasin, desensitizes peptidergic nociceptors by acting on TRPA1 cation channel. BRITISH JOURNAL OF PHARMACOLOGY, vol. 174, pp. 2897-2911, ISSN:0007-1188 DOI Accesso ONLINE all'editore

Jensen DD, Lieu TM, Hall ML, Veldhuis NA, Imlach WL, Mai QN, Poole DP, Quach T, Aurelio L, Conner J, Herenbrink CK, Barlow N, Simpson JS, Scanlon MJ, Graham B, McCluskey A, Robinson PJ, Escriou V, Nassini R; Materazzi S, Geppetti P, Hicks GA, Christie MJ, Porter CJH, Canals M, Bunnett NW. (2017). Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief. SCIENCE TRANSLATIONAL MEDICINE, vol. 9, pp. eaal3447-eaal3447, ISSN:1946-6234 DOI Accesso ONLINE all'editore

Materazzi S, Zagli G, Nassini R, Bartolini I, Romagnoli S, Chelazzi C, Benemei S, Coratti A, De Gaudio AR, Patacchini R. (2016). Vasodilator activity of hydrogen sulfide (H2S) in human mesenteric arteries. MICROVASCULAR RESEARCH, vol. 109, pp. 38-44, ISSN:0026-2862 DOI

De Logu F, Tonello R, Materazzi S, Nassini R, Fusi C, Coppi E, Li Puma S, Marone IM, Sadofsky LR, Morice AM, Susini T, Terreni A, Moneti G, Di Tommaso M, Geppetti P, Benemei S. (2016). TRPA1 mediates aromatase inhibitor-evoked pain by the aromatase substrate androstenedione. CANCER RESEARCH, vol. 76, pp. 7024-7035, ISSN:0008-5472 DOI Accesso ONLINE all'editore

Prandini P, De Logu F, Fusi C, Provezza L, Nassini R, Montagner G, Materazzi S, Munari S, Gilioli E, Bezzerri V, Finotti A, Lampronti I, Tamanini A, Dechecchi MC, Lippi G, Ribeiro CM, Rimessi A, Pinton P, Gambari, R, Geppetti P, Cabrini G. (2016). Transient Receptor Potential Ankyrin 1 Channels Modulate Inflammatory Response in Respiratory Cells from Patients with Cystic Fibrosis. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, vol. 55, pp. 645-656-656, ISSN:1044-1549 DOI

Benemei S, Nassini R, Materazzi S, Geppetti P. (2016). Keep in Mind TRPA1 When Prescribing Metamizole!. PAIN PRACTICE, vol. 16, pp. 110-110, ISSN:1530-7085 DOI Accesso ONLINE all'editore

Trevisan G, Benemei S, Materazzi S, De Logu F, De Siena G, Fusi C, Fortes Rossato M, Coppi E, Marone IM, Ferreira J, Geppetti P, Nassini R. (2016). TRPA1 mediates trigeminal neuropathic pain in mice downstream of monocytes/macrophages and oxidative stress. BRAIN, vol. 139, pp. 1361-1377, ISSN:0006-8950 DOI Accesso ONLINE all'editore

Falanga A, Marchetti M, Massi D, Merelli B, Verzeroli C, Russo L, Rulli E, Tondini C, Legramandi L, Nassini R, Scatena C, De Logu F, Cattaneo L, Mandalà M. (2016). Thrombophilic status may predict prognosis in patients with metastatic BRAFV600-mutated melanoma who are receiving BRAF inhibitors.. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, vol. 74(6):, pp. 1254-1256, ISSN:0190-9622 DOI

Malerba F, Paoletti F, Ercole BB, Materazzi S, Nassini R, Coppi E, Patacchini R, Capsoni S, Lamba D, Cattaneo A. (2015). Functional characterization of human ProNGF and NGF mutants: Identification of NGF P61SR100E as a "Painless" lead investigational candidate for therapeutic applications. PLOS ONE, vol. 10, pp. e0136425-e0136425, ISSN:1932-6203 DOI Accesso ONLINE all'editore

Nassini R, Fusi C, Materazzi S, Coppi E, Tuccinardi T, Marone IM, De Logu F, Preti D, Tonello R, Chiarugi A, Patacchini R, Geppetti P, Benemei S. (2015). The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives. BRITISH JOURNAL OF PHARMACOLOGY, vol. 172, pp. 3397-3411, ISSN:1476-5381 DOI Accesso ONLINE all'editore

Giustarini D, Galvagni F, Tesei A, Farolfi A, Zanoni M, Pignatta S, Milzani A, Marone IM, Dalle-Donne I, Nassini R, Rossi R. (2015). Glutathione, glutathione disulfide, and S-glutathionylated proteins in cell cultures. FREE RADICAL BIOLOGY & MEDICINE, vol. 89, pp. 972-981, ISSN:0891-5849 DOI Accesso ONLINE all'editore

Massi D, Brusa D, Merelli B, Falcone C, Xue G, Carobbio A, Nassini R, Baroni G, Tamborini E, Cattaneo L, Audrito V, Deaglio S, Mandalà M. (2015). The status of PD-L1 and tumor-infiltrating immune cells predict resistance and poor prognosis in BRAFi-treated melanoma patients harboring mutant BRAF<sup>V600</sup>. ANNALS OF ONCOLOGY, vol. 26, pp. 1980-1987, ISSN:0923-7534 DOI Accesso ONLINE all'editore

Materazzi S, Minocci D, De Siena G, Benemei S, Nassini R. (2015). Ureteral relaxation through calcitonin gene-related peptide release from sensory nerve terminals by hypotonic solution. INTERNATIONAL JOURNAL OF UROLOGY, vol. 22, pp. 878-883, ISSN:1442-2042 DOI

Calvani M, Pelon F, Comito G, Taddei ML, Moretti S, Innocenti S, Nassini R, Gerlini S, Borgognoni, Bambi F, Giannoni E, Filippi L, Chiarugi P. (2015). Norepinephrine promotes tumor microenvironment reactivity through β3-adrenoreceptors during melanoma progression.. ONCOTARGET, vol. 6, pp. 4615-4632, ISSN:1949-2553 DOI Accesso ONLINE all'editore

Massi D, Brusa D, Merelli B, Ciano M, Audrito V, Serra S, Buonincontri R, Baroni G, Nassini R, Minocci D; Cattaneo L, Tamborini E, Carobbio A, Rulli E, Deaglio S, Mandalà M. (2014). PD-L1 marks a subset of melanomas with a shorter overall survival and distinct genetic and morphological characteristics.. ANNALS OF ONCOLOGY, vol. 25, pp. 2433-2442, ISSN:0923-7534 DOI Accesso ONLINE all'editore

Trevisan G, Hoffmeister C, Rossato MF, Oliveira, Silva MA, Silva CR,Fusi C, Tonello R, Minocci D, Guerra GP, Materazzi S, Nassini R, Geppetti P, Ferreira J. (2014). TRPA1 receptor stimulation by hydrogen peroxide is critical to trigger hyperalgesia and inflammation in a model of acute gout.. FREE RADICAL BIOLOGY & MEDICINE, vol. 72, pp. 200-209, ISSN:0891-5849 DOI Accesso ONLINE all'editore

Lieu T, Jayaweera G, Zhao P, Poole DP, Jensen D, Grace M, McIntyre P, Bron R, Wilson YM, Krappitz M, Haerteis S, Korbmacher C, Steinhoff MS, Nassini R, Materazzi S, Geppetti P, Corvera CU, Bunnett NW. (2014). The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice.. GASTROENTEROLOGY, pp. 1417-1428, ISSN:0892-1601

Fusi C, Materazzi S, Minocci D, Maio V, Oranges T, Massi D, Nassini R. (2014). Transient Receptor Potential Vanilloid 4 (TRPV4) is Down-Regulated in Keratinocytes in Human Non-Melanoma Skin Cancer.. JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 134(9), pp. 2408-2417, ISSN:0022-202X DOI

de Moura JC, Noroes MM, Rachetti Vde P, Soares BL, Preti D, Nassini R, Materazzi S, Marone IM, Minocci D, Geppetti P, Gavioli EC, André E. (2014). The blockade of transient receptor potential ankirin 1 (TRPA1) signalling mediates antidepressant- and anxiolytic-like actions in mice.. BRITISH JOURNAL OF PHARMACOLOGY, vol. 171, pp. 4289-4299, ISSN:0007-1188 DOI Accesso ONLINE all'editore

Nassini R, Materazzi S, Benemei S, Geppetti P. (2014). The TRPA1 Channel in Inflammatory and Neuropathic Pain and Migraine. REVIEWS OF PHYSIOLOGY BIOCHEMISTRY AND PHARMACOLOGY, vol. 167, pp. 1-43, ISSN:0303-4240 DOI Accesso ONLINE all'editore

Fusi C, Benemei S, Coppi E, Trevisan Dos Santos G, Marone IM, Minocci D, De Logu F, Di Tommaso M, Susini T, Moneti G, Pieraccini G, Geppetti P, Materazzi S, Nassini R. (2014). Steroidal and non-steroidal third-generation aromatase inhibitors induce pain-like symptoms via TRPA1. NATURE COMMUNICATIONS, vol. 5, pp. 5736-5749, ISSN:2041-1723 DOI Accesso ONLINE all'editore

Geppetti P, Patacchini R, Nassini R. (2014). Transient receptor potential channels and occupational exposure.. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, vol. 14, pp. 77-83, ISSN:1528-4050 DOI Accesso ONLINE all'editore

Materazzi S, Benemei S, Fusi C, Gualdani R, De Siena G, Vastani N, Andersson DA, Trevisan G, Moncelli MR, Wei X, Dussor G, Pollastro F, Patacchini R, Appendino G, Geppetti P, Nassini R. (2013). Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel. PAIN, vol. 154, pp. 2750-2758, ISSN:0304-3959 DOI Accesso ONLINE all'editore

Trevisan G, Hoffmeister C, Rossato MF, Oliveira SM, Silva MA, Ineu RP, Guerra GP, Materazzi S, Fusi C, Nassini R, Geppetti P, Ferreira J. (2013). TRPA1 receptor stimulation by hydrogen peroxide is critical to trigger pain during MSU-induced inflammation.. ARTHRITIS AND RHEUMATISM, pp. ---, ISSN:0004-3591

Alemi F, Kwon E, Poole DP, Lieu T, Lyo V, Cattaruzza F, Cevikbas F, Steinhoff M, Nassini R, Materazzi S, Guerrero-Alba R, Valdez-Morales E, Cottrell GS, Schoonjans K, Geppetti P, Vanner SJ, Bunnett NW, Corvera CU. (2013). The TGR5 receptor mediates bile acid-induced itch and analgesia.. THE JOURNAL OF CLINICAL INVESTIGATION, pp. 1513-1530, ISSN:0021-9738

Trevisan G, Materazzi S, Fusi C, Altomare A, Aldini G, Lodovici M, Patacchini R, Geppetti P, Nassini R. (2013). Novel Therapeutic Strategy to Prevent Chemotherapy-Induced Persistent Sensory Neuropathy By TRPA1 Blockade. CANCER RESEARCH, pp. 3120-3131, ISSN:0008-5472

Trevisan G, Hoffmeister C, Rossato MF, Oliveira SM, Silva MA, Ineu RP, Guerra GP, Materazzi S, Fusi C, Nassini R, Geppetti P, Ferreira J. (2013). Transient receptor potential ankyrin 1 receptor stimulation by hydrogen peroxide is critical to trigger pain during monosodium urate-induced inflammation in rodents. ARTHRITIS AND RHEUMATISM, vol. 65, pp. 2984-2995, ISSN:0004-3591 DOI

Nassini R, Pedretti P, Moretto N, Fusi C, Carnini C, Facchinetti F, Viscomi AR, Pisano AR, Stokesberry S, Brunmark C, Svitacheva N, McGarvey L, Patacchini R, Damholt AB, Geppetti P, Materazzi S. (2012). Transient Receptor Potential Ankyrin 1 Channel Localized to Non-Neuronal Airway Cells Promotes Non-Neurogenic Inflammation. PLOS ONE, pp. 1-12, ISSN:1932-6203 DOI

Pozsgai G, Hajna Z, Bagoly T, Boros M, Kemény A, Materazzi S, Nassini R, Helyes Z, Szolcsányi J, Pintér E. (2012). The role of transient receptor potential ankyrin 1 (TRPA1) receptor activation in hydrogen-sulphide-induced CGRP-release and vasodilation. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 689, pp. 54-64, ISSN:0014-2999 DOI

Edelmayer RM, Le LN, Yan J, Wei X, Nassini R, Materazzi S, Preti D, Appendino G, Geppetti P, Dodick DW, Vanderah TW, Porreca F, Dussor G. (2012). Activation of TRPA1 on dural afferents: a potential mechanism of headache pain. PAIN, vol. 153, pp. 1949-1958, ISSN:0304-3959 DOI

Baraldi PG, Romagnoli R, Saponaro G, Aghazadeh Tabrizi M, Baraldi S, Pedretti P, Fusi C, Nassini R, Materazzi S, Geppetti P, Preti D. (2012). 7-Substituted-pyrrolo[3,2-d]pyrimidine-2,4-dione derivatives as antagonists of the transient receptor potential ankyrin 1 (TRPA1) channel: A promising approach for treating pain and inflammation.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 20, pp. 1960-1968, ISSN:1464-3391

Nassini R, Materazzi S, Vriens J, Prenen J, Benemei S, De Siena G, la Marca G, Andrè E, Preti D, Avonto C, Sadofsky L, Di Marzo V, De Petrocellis L, Dussor G, Porreca F, Taglialatela-Scafati O, Appendino G, Nilius B, Geppetti P. (2012). The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system. BRAIN, vol. 135, pp. 376-390, ISSN:0006-8950 DOI Accesso ONLINE all'editore

Materazzi S, Fusi C, Benemei S, Pedretti P, Patacchini R, Nilius B, Prenen J, Creminon C, Geppetti P, Nassini R. (2012). TRPA1 and TRPV4 mediate paclitaxel-induced peripheral neuropathy in mice via a glutathione-sensitive mechanism. PFLÜGERS ARCHIV, vol. 463, pp. 561-569, ISSN:0031-6768 DOI

Nassini R, Marteen G, Harrison S, De Siena G, Materazzi S, Moretto N, Failli P, Preti D, Marchetti N, Cavazzini A, Mancini F, Pedretti P, Nilius B, Patacchini R, Geppetti P. (2011). Oxaliplatin elicits mechanical and cold allodynia via TRPA1 receptor stimulation and oxidative stress byproducts. INFLAMMATION RESEARCH, pp. 205-205, ISSN:1023-3830

Berti S, Amato L, Arunachalam M, Spallanzani A, Prignano F, Nassini R, Massi D, Colucci R, Moretti S. (2011). Mast cells do not play a role in vitiligo. EUROPEAN JOURNAL OF DERMATOLOGY, vol. 21, pp. 800-801, ISSN:1167-1122

Benemei S; Nassini R; Materazzi S; Vriens J; Prenen J; De Siena G ; Avonto C; Di Marzo V; De Petrocellis L ; Dussor G; Porreca F; O. Taglialatela-Scafati O; Appendino G; Nilius B;Geppetti P (2011). Umbellulone, the offensive principle of the headache tree (umbellularia californica), stimulates the trigeminovascular system via TRPA1 activation.. INFLAMMATION RESEARCH, pp. 204-204, ISSN:1023-3830

Nassini R; Gees M; Harrison S; G. De Siena G; Materazzi S; Moretto N; Failli P; Preti D; Marchetti N; Cavazzini A; Mancini F; Pedretti P; Nilius B; Patacchini R; Geppetti P. (2011). Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation.. PAIN, vol. 152, pp. 1621-1631, ISSN:0304-3959

Nassini R, Gees M, Harrison S, De Siena G, Materazzi S, Moretto N, Failli P, Preti D, Marchetti N, Cavazzini A, Mancini F, Pedretti P, Nilius B, Patacchini R, Geppetti P. (2011). OXALIPLATIN ELICITS MECHANICAL AND COLD ALLODYNIA IN RODENTS VIA TRPA1 RECEPTOR STIMULATION. INFLAMMATION RESEARCH, vol. 60, S 1, pp. 205-205, ISSN:1023-3830

Nassini R; Benemei S; Materazzi S; De Siena G; Pedretti P; Mancini F; Trevisani M; Patacchini R; Geppetti P (2010). The stimulation of the TRPA1 channel on the trigeminovascular system activates the nociceptive pathway and elicits CGRP-mediated vasodilatation.. NEUROPEPTIDES, vol. 44, pp. 522-522, ISSN:0143-4179

Materazzi S; Nassini R; Andrè E; Gatti R; Trevisani M; Patacchini R; Geppetti P (2010). The contribute of TRPA1 channel in inflammatory respiratory disease. NEUROPEPTIDES, vol. 44, pp. 536-536, ISSN:0143-4179

Geppetti P; Patacchini R; Nassini R; Materazzi S. (2010). Cough: The Emerging Role of the TRPA1 Channel.. LUNG, vol. 188 Suppl 1, pp. S63-8, ISSN:0341-2040

Nassini R, Materazzi S, Andrè E, Sartiani L, Aldini G, Trevisani M, Carnini C, Massi D, Pedretti P, Carini M, Cerbai E, Preti D, Villetti G, Civelli M, Trevisan G, Azzari C, Stokesberry S, Sadofsky L, McGarvey L, Patacchini R, Geppetti P. (2010). Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents.. FASEB JOURNAL, vol. 24, pp. 4904-4916, ISSN:1530-6860 DOI

Nassini R, Materazzi S, De Siena G, De Cesaris F, Geppetti P. (2010). Transient receptor potential channels as novel drug targets in respiratory diseases.. CURRENT OPINION IN INVESTIGATIONAL DRUGS, vol. 11, pp. 535-542, ISSN:2040-3429

S. Materazzi; A. Tchoimou; R. Nassini; M. Trevisani; P. Geppetti (2010). The role of TRPV1 in respiratory disease.. In: S. Materazzi, A. Tchoimou, R. Nassini, M. Trevisani, P. Geppetti. Vanilloid receptor TRPV1 in drug discovery. targeting pain and other pathological disorders, pp. 403-423, New Jersey: Gomtsyan and Faltynek ed..

Nassini R, Andrè E, Gazzieri D, De Siena G, Zanasi A, Geppetti P, Materazzi S. (2010). A bicarbonate-alkaline mineral water protects from ethanol-induced hemorrhagic gastric lesions in mice.. BIOLOGICAL & PHARMACEUTICAL BULLETIN, vol. 33, pp. 1319-1323, ISSN:1347-5215

Vergnolle N, Cenac N, Altier C, Cellars L, Chapman K, Zamponi GW, Materazzi S, Nassini R, Liedtke W, Cattaruzza F, Grady EF, Geppetti P, Bunnett NW. (2010). A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation.. BRITISH JOURNAL OF PHARMACOLOGY, vol. 159, pp. 1161-1173, ISSN:0007-1188

Eilers H, Cattaruzza F, Nassini R, Materazzi S, Andre E, Chu C, Cottrell GS, Schumacher M, Geppetti P, Bunnett NW. (2010). Pungent general anesthetics activate transient receptor potential-A1 to produce hyperalgesia and neurogenic bronchoconstriction.. ANESTHESIOLOGY, vol. 112, pp. 1452-1463, ISSN:0003-3022

Moretti S, Nassini R, Prignano F, Pacini A, Materazzi S, Naldini A, Simoni A, Baroni G, Pellerito S, Filippi I, Lotti T, Geppetti P, Massi D. (2009). Protease-activated receptor-2 downregulation is associated to vitiligo lesions. PIGMENT CELL & MELANOMA RESEARCH, vol. 22, pp. 335-338, ISSN:1755-1471 DOI

S. Benemei; F. De Cesaris; P. Nicoletti; S. Materazzi; R. Nassini; P. Geppetti. (2009). Migraine Models. In: S. Benemei, F. De Cesaris, P. Nicoletti, S. Materazzi, R. Nassini P. Geppetti.. Analgesia: Methods and Protocols, Methods in Molecular Biology, pp. 105-114, Long Branch, NJ, USA: Arpad Szallasi ed.

Moretti S, Fabbri P, Baroni G, Berti S, Bani D, Berti E, Nassini R, Lotti T, Massi D. (2009). Keratinocyte dysfunction in vitiligo epidermis: cytokine microenvironment and correlation to keratinocyte apoptosis. HISTOLOGY AND HISTOPATHOLOGY, vol. 24, pp. 849-857, ISSN:0213-3911

R. Nassini (2009). THE TRPA1 CHANNEL, MORE THAN JUST A SPICE RECEPTOR.ROLE IN INFLAMMATION AND PAIN TRANSMISSION..

Materazzi, S; Nassini, R; Gatti, R; Trevisani, M; Geppetti, P (2009). Cough sensors. II. Transient receptor potential membrane receptors on cough sensors. In: Barrett, James E.. HANDBOOK OF EXPERIMENTAL PHARMACOLOGY, pp. 49-61 Springer.

Geppetti P; Nassini R; Materazzi S; Benemei S. (2008). The concept of neurogenic inflammation. BJU INTERNATIONAL, vol. 101 Suppl. 3, pp. 2-6, ISSN:1464-410X DOI Accesso ONLINE all'editore

Massi D, Nassini R, Materazzi S, Naldini A, Prignano F, Pacini A, Tarantini F, Moretti S. (2008). PAR-2 is downregulated in keratinocytes from vitiligo lesions.. LABORATORY INVESTIGATION, vol. 88, pp. 98A-98A, ISSN:0023-6837

S. Materazzi; R. Nassini; S. Benemei; S. Castellani; P. Geppetti (2008). Detrimental and Beneficial Effects of Ethanol by Stimulation of TRPV1 in Sensory Neurons. In: The 17th National Congress of Cerebrovascular Diseases, The SINV, Montecatini Terme, 2008, Montecatini Terme, 11-13/12/2008, Karger, vol. 26(Suppl 2) 1-30 (2008), pp. 25-26, ISBN:9783805590679 DOI Accesso ONLINE all'editore

Andrè E, Campi B, Materazzi S, Trevisani M, Amadesi S, Massi D, Creminon C, Vaksman N, Nassini R, Civelli M, Baraldi PG, Poole DP, Bunnett NW, Geppetti P, Patacchini R. (2008). Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents.. THE JOURNAL OF CLINICAL INVESTIGATION, vol. 118, pp. 2574-2582, ISSN:0021-9738

E. Andre; S. Materazzi; R. Nassini; S. Amadesi; R. Patacchini; P. Geppetti; N. W. Bunnett (2008). Reactive prostaglandins (PG) activate transient receptor potential (TRP) A1 on nociceptive neurons to induce pain. In: Digestive Disease Week (DDW), San Diego, CA, May 17 - 22, 2008, vol. 134, pp. A556-A556.

S. Moretti; G. Baroni; A. Naldini; A. Simoni; F. Prignano; T. Lotti; F. Tarantini; S. Materazzi; R. Nassini; D. Massi (2007). Involvement of PAR-2 in vitiligo. In: 16° Meeting of the European Society for Pigment Cell Resarch (ESPCR 2007), Bari, vol. 20, pp. 420-420.

P. Geppetti; R. Nassini; M. Trevisani (2007). Rationale for vanniloid receptor 1 antagonist-based therapies in asthma. In: R. Polosa, S.T. Holgate. ASTHMA Modern Therapeutic Targets, pp. 117-127, Oxford UK: R. Polosa, S.T. Holgate, ISBN:9781846920158.

Trevisani M, Siemens J, Materazzi S, Bautista DM, Nassini R, Campi B, Imamachi N, Andrè E, Patacchini R, Cottrell GS, Gatti R, Basbaum AI, Bunnett NW, Julius D, Geppetti P. (2007). 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1.. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 104, pp. 13519-13524, ISSN:0027-8424

Romina NASSINI

Curriculum

Romina Nassini, PhD

Curriculum Vitae

Education and Training

2005 Degree in Biological Science, University of Florence

2006 Research Fellowship, University of Florence, Department of Critical Care Medicine and Surgery

2007-2009 PhD in Clinical Pathophysiology and Aging, University of Florence, Department of Critical Care Medicine and Surgery

2007-Nov Research Scholarship University of California, San Francisco, U.S.A. Department of Surgery and Physiology-Centre for the Neurobiology and Digestive Diseases,

2010-2015 Residency in Clinical Pathology, University of Pisa

Academic Position

2010-2017 Assistant Professor (grade A), University of Florence, Department of Health Sciences Clinical Pharmacology and Oncology Unit.

2018-today Assistant Professor (grade B), University of Florence, Department of Health Sciences Clinical Pharmacology and Oncology Unit.

Prizes and awards

2008 Award at the 18th Annual Congress European Respiratory Society, Berlin, Germany, 4-8 October 2008 for an oral presentation entitled “Cigarette smoke-induced airway neurogenic inflammation is mediated by α,ß-unsaturated aldehydes and the TRPA1 receptor”. Nassini R, Andrè E, Campi B, Materazzi S, Trevisani M, Amadesi S, Massi D, Creminon C, Vaksman N, Civelli M, Bunnett NW, Geppetti P and Patacchini R.

2010 Best poster Award at the 7th Joint Meeting of the European Neuropeptide Club and the American-Summer-Neuropeptide Conference, Pecs, Hungary, 22-24 June 2010. Nassini R, Benemei S, Materazzi S, De Siena G, Pedretti P, Mancini F, Trevisani M, Patacchini R and Geppetti P. “The stimulation of the TRPA1 channel on the trigeminovascular system activates the nociceptive pathway and elicits CGRP-mediated vasodilatation”.

2011 Italian National Award “Nottola-Mario Luzi, Il dolore non necessario” Edition 2011, for the best scientific work published: Nassini R, Gees M, Harrison S, De Siena G, Materazzi S, Moretto N, Failli P, Preti D, Marchetti N, Cavazzini A, Mancini F, Pedretti P, Nilius B, Patacchini R, Geppetti P. “Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation” Pain. 2011;152(7):1621-31.

2012 Young Investigator Award. Grant for the participation at the Summer Conference British Pharmacological Society, Focused Meeting on Neuropeptides, London, UK, 7–9 June 2012.

2012 Award at the 14th World Congress on Pain, Milan, Italy, 27-31 August 2012 for a poster presentation entitled “Transient receptor potential ankyrin 1 (TRPA1) and vanilloid 4 (TRPV4) mediate anticancer drugs-induced peripheral neuropathy”. Nassini R, Fusi C, Benemei S, Pedretti P, Patacchini R, Nilius B, Prenen J, Creminon C, Geppetti P, Materazzi S.

2012 Young Investigators Awards 2012 of the Federation of European Pharmacological Societies (EPHAR) for the scientific publication: The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system. Brain. 2012;135(Pt 2):376-90. Nassini R, Materazzi S, Vriens J, Prenen J, Benemei S, De Siena G, la Marca G, Andrè E, Preti D, Avonto C, Sadofsky L, Di Marzo V, De Petrocellis L, Dussor G, Porreca F, Taglialatela-Scafati O, Appendino G, Nilius B, Geppetti P.

Financial Grants

2006 Participant. FIRB 2006: ‘Studio dei meccanismi molecolari responsabili della patogenesi e progressione della broncopneumopatia cronica ostruttiva (BPCO) per la identificazione di nuovi bersagli terapeutici. Protocol number. RBIP06YM29.

2008 Participant. PRIN 2008: ‘Il PAR2 e specie reattive dell'ossigeno e dell'azoto: doppio effetto proinfiammatorio nel sistema respiratorio, cutaneo e gastrointestinale’ Protocol number. 2008T5BLWA_004.

2009 Participant. Istituto Italiano Tecnologia (IIT)_Project SEED 2009: ‘TRPA1 channel in nociceptive neurons: target validation and identification of antagonists for intractable pain’.

2010 Principal Investigator. Fondazione Ente Cassa di Risparmio di Firenze (ECFR): ‘Agenti endogeni e xenobiotici, attivatori del sistema trigemino-vascolare, come fattori scatenanti l’emicrania’ Protocol number: 2010.1020.

2012 Principal Investigator. AIRC Associazione Italiana per la ricerca sul cancro: My First AIRC Grant (MFAG) 2012: 'Chemotherapy-induced peripheral neuropathy: role of transient receptor potential channels' Number: 13336.

2014 Partner. Fondazione Fibrosi Cistica, Project FFC # 17/2014 TRPA1 channels as novel molecular targets for anti-inflammatory therapies in CF lung. Coordinator: Giulio Cabrini (University Hospital of Verona)

2016-2018 Participant. ISTITUTO TOSCANO TUMORI–REGIONE TOSCANA “Aromatase inhibitors induced pain via the activation of the TRPA1 channel”.

2017 Principal Investigator. AIRC Associazione Italiana per la ricerca sul cancro: Investigator Grant 2016: AIRC IG2016 cod. 19247 "Cancer-related pain syndromes: the role of oxidative stress and the TRPA1 and TRPV4 channels”.

2019 Participant. European Research Council (ERC) grant under the European Union’s Horizon 2020 research and innovation programme (grant agreement No. 835286) "Schwann Cell Options for chronic Pain Eradication_Scope”.

Selected or Invited speaker

2008 18^th Annual Congress European Respiratory Society, Berlin, Germany, 4

2012 Summer Conference BPS Focused Meeting on Neuropeptides, London, UK,

2014 Scientific Workshop COLLEGIO dei PROFESSORI di ANATOMIA PATOLOGICA. Pisa

2013 36^th Congresso Associazione Italiana per lo Studio del Dolore (AISD) Le nuove frontiere della medicina del dolore Verona.

2013 XX Convegno annuale Associazione Italiana per le Scienze degli Animali da Laboratorio (AISAL) Riconoscimento e gestione del dolore animale nella ricerca biomedica e veterinaria Imola.

2015 10^th Annual Scientific Conference of Tuscan Cancer Institute (ITT) Pisa. Italy

2015 Conference ‘New drugs for asma e BPCO: what is changed, Ravenna, Italy

2015 National congress, Società Italiana di Farmacologia (SIF). I nuovi orizzonti della ricerca farmacologica: tra etica e scienza Napoli

2017 Pharmacology Conference THE PHARMACOLOGICAL BASIS OF NOVEL PAIN THERAPEUTICS. Florence

2016 Institute of Biology, Department of Neurobiology and Program of Neurosciences, Fluminense Federal University, Niterói, RJ, Brazil.

2019 7^th International Congress on Neuropathic Pain (NeuPSIG 2019), London, UK.

2019 33^rd Congresso Nazionale della Società Italiana per lo Studio delle Cefalee (SISC), Napoli.

2019 Teaching course on ‘Application of immunohistochemistry in pharmacology’ Universidade Federal de Santa Maria-Department of Physiology and Pharmacology, Santa Maria, Brazil.

Scientific society member

Società Italiana di Farmacologia (SIF), International Association for the Study of Pain (IASP), Società Italiana per lo Studio delle Cefalee (SISC), Associazione Italiana per lo Studio del Dolore (AISD).

Reviewer

European Journal of Pharmacology, Brain Research, Journal of Basic and Clinical Physiology and Pharmacology, Journal of Neuroscience Research, Neuropharmacology, Life Sciences, Molecular Immunology, Neuroscience Letters, Pain Research and Treatment, Mediators of Inflammation, Pharmacology, Biochemistry and Behavior, Fitoterapia, Scientific Reports, Toxicological Sciences, Virchows Archiv-European Journal of Pathology.

Scientific activity

Romina Nassini is a basic scientist whose research interest focuses on the identification of new activators and inhibitors of the TRP channels and the molecular and translational aspects of these mechanisms. Romina has contributed to the identification of pathways by which inflammatory mediators signal to sensory nerves by gating receptors and channels, to cause pain in different models of cancer-related pain, including those due to the use of chemotherapeutic drugs, and models of pain due to cancer growth. More recently, Romina has contributed substantially to the identification of a novel mechanism (the TRPA1/NOX1 pathway) in Schwann cells, which, sustaining neuroinflammation, signals chronic neuropathic pain.

Scientific records

Romina Nassini is author of 88 peer-reviewed articles, 6 book chapters e 6 conference proceedings.

Total Citations = 5993; H-Index 41 (Scopus Basic Search)