Disponibile su appuntamento (email: annarosa.arcangeli@unifi.it)
La Prof.Annarosa Arcangeli è nata a Pistoia il 20/7/1956; laureata in Medicina e Chirurgia nel 1981, specialista in Ematologia Clinica e di Laboratorio nel 1984; Dottore di Ricerca in Patologia Sperimentale nel 1990; dal 2012 Professore Ordinario di Patologia Generale presso la Facoltà di Medicina e Chirurgia dell’Università di Firenze. La Prof.ssa Arcangeli ha una lunga esperienza in ricerche sui canali ionici e sul loro ruolo nella trasformazione neoplastica. E’ per questo uno degli esperti mondiali di hERG, e del suo ruolo nel cancro. A seguito di diversi periodi di lavoro presso l’Università di Cambridge, la Prof.ssa Arcangeli ha anche acquisito notevole esperienza biotecnologica per la manipolazione genetica di mammiferi allo scopo di produrre animali geneticamente modificati, nonché per la produzione di anticorpi monoclonali tramite l’uso di proteine ricombinanti in E. Coli e in lieviti. Dal 2006 è responsabile del Laboratrio di Ingegneria Genetica per la produzione di Modelli Animali (L.I.Ge.M.A.), laboratorio congiunto dell’Università di Firenze e dell’Istituto Toscano Tumori. E’ socio fondatore dello spin-off universitario Dival Toscana Srl, costituitosi nel 2012.
La prof.ssa Arcangeli è autrice di 92 pubblicazioni su riviste internazionali, 15 capitoli di libri e detentrice di 4 brevetti. E’ stata relatore di più di 300 tesi di laurea, e supervisore di 28 studenti di Dottorato, fra cui 2 internazionali.
Legenda
Annarosa Arcangeli.
Personal Data:
Date and place of birth: 20/7/1956, Pistoia, Italy
Address: Via G. del Pian dei Carpini 96/1, 50127, Firenze, Italy
Marital status: married; two children.
Education:
1975-1981- University of Florence, School of Medicine, M.D. (magna cum laude)
1981-1984- University of Florence, School of Medicine, Specialisation in Clinical and Laboratory Haematology (magna cum laude).
1986-1990- University of Florence, PhD in Experimental Pathology, 1990
Academic and Professional Appointments:
1983-1984: Fellowship of the Italian League against tumours
1984-1986: Fellowship of the Italian Association for Cancer Research
1990-1994: Fellowship of the Italian Association Against Leukaemia
1994-1998: Researcher in General Pathology, University of Florence
1998- 2012: Associate Professor of General Pathology, University of Florence
2002-2004. Member of the Committtee on Equal Opportunities of the University of Florence
2005-2007: President Associazione Italiana contro le Leucemie (AIL)- Pistoia
2006-present: Scientific Director of LIGeMA (a facility of the University of Florence and of Isituto Toscano Tumori for the production of transgenic mice as models for oncological research)
2010-present: Elected Member of the Board of the Associazione di Biologia Cellulare e del Differenziamento (ABCD)
2012-present: Co-founder and scientific director of the spin-off of the University of Florence Dival-Toscana Srl.
December 2012: Full professor of General Pathology, University of Florence, School of Medicine.
Visiting Scientist:
1982:Laboratory of Dr. G.Clarke, Imperial Cancer Research Fund, London, UK
1986-87:Laboratory of Electrophysiology (chairmam Dr.E.Wanke), University of Milano, Italy.
1994 :Laboratory of Dr Catherine Ziller, Istitut d'Embryologie Cellulaire et Moleculaire (chairman Prof.N.M.Le Douarin), Paris, France.
1997:"ICRF Cell Interaction Laboratory" (Dr.E, Gherardi), Medical Research Council, Cambridge, UK (as fellowship of the Italian Foundation for Cancer Research).
2002- “MRC- Growth Factors Group (Dr. E.Gherardi) Medical Research Council, Cambridge, UK (as fellowship of the Italian Foundation for Cancer Research).
2003: Dr. Sam Aparicio: Deparment of Oncology. University of Cambridge.
2007: Dr. E. Gherardi, Growth factors Group, MRC-LMB, Cambridge
Scientific Society Memberships:
Member of SIP (Società Italiana di Patologia), ABCD (Associazione di Biologia Cellulare e Differenziamento), ASH (American Society of Hemathology), EACR (European Association for Cancer Research).
Scientific interests:
Since almost thirty years Dr. Arcangeli is being involved in studies aimed at defining the biophysical aspects of intracellular signalling controlling cell growth and differentiation of tumor cells. She contributed to unravel the action mechanism of widely used inducers of tumor cell differentiation, such as the "hybrid polar compounds" (HPC). She also focused on the role of potassium channels, in particular the hERG1 channel, in the govern of the resting potential, cellular ionic homeostasis and cell signalling in normal and cancer cells. In this field, Dr. Arcangeli acquired most of the methodologies required to accomplish the present proposal, in particular gene manipulation, biomolecular techniques and patch clamping. Meanwhile, in the last few years she exploited her skill in mouse transgenesis and in vivo experiments in immunodeficient mice. These studies led to discovery that, in many human and experimental tumors, the resting potential is controlled by hERG1, an important family of recently discovered potassium channels. Moreover, Dr. Arcangeli integrating biophysical, biomolecular and genetic approaches unravelled the role of potassium channels and their encoding genes, in embryonic development and tumor establishment.
