_SKIPNAVIGATION
ITA |
ENG
Personale
Recapiti
Pagina Cercachi
Italiano
Pubblicazioni
Insegnamenti
Alessio NOCENTINI
Ruolo attuale:
Ricercatore Legge 240/10 a tempo determinato
SSD:
CHEM-07/A - Chimica farmaceutica
Afferenza organizzativa:
Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino (NEUROFARBA)
Recapiti
alessio.nocentini(AT)unifi.it
Alessio NOCENTINI
Pubblicazioni
Legenda
Contributo su rivista |
Articolo su libro |
Libro |
Contributo in atti di convegno (proceeding) |
Brevetto |
Curatela |
Altro |
Tesi di Dottorato
Bua, Silvia; Bonardi, Alessandro; Mük, Georgiana Ramona; Nocentini, Alessio; Gratteri, Paola; Supuran, Claudiu T. (2024). Benzothiadiazinone-1,1-Dioxide Carbonic Anhydrase Inhibitors Suppress the Growth of Drug-Resistant Mycobacterium tuberculosis Strains. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 25, pp. 0-0, ISSN:1422-0067
DOI
Fuentes-Aguilar, Alma; González-Bakker, Aday; Jovanović, Mirna; Stojanov, Sofija Jovanović; Puerta, Adrián; Gargano, Adriana; Dinić, Jelena; Vega-Báez, José L.; Merino-Montiel, Penélope; Montiel-Smith, Sara; Alcaro, Stefano; Nocentini, Alessio; Pešić, Milica; Supuran, Claudiu T.; Padrón, José M.; Fernández-Bolaños, José G.; López, Óscar (2024). Coumarins-lipophilic cations conjugates: Efficient mitocans targeting carbonic anhydrases. BIOORGANIC CHEMISTRY, vol. 145, pp. 0-0, ISSN:0045-2068
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Tawfik, Haytham O.; Saleh, Mohamed M.; Ammara, Andrea; Khaleel, Eman F.; Badi, Rehab; Khater, Yomna T. T.; Rasheed, Rabab A.; Attia, Ahmed A.; Hefny, Salma M.; Elkaeed, Eslam B.; Nocentini, Alessio; Supuran, Claudiu T.; Eldehna, Wagdy M.; Shaldam, Moataz A. (2024). Discovery of Novel Pyridazine-Tethered Sulfonamides as Carbonic Anhydrase II Inhibitors for the Management of Glaucoma. JOURNAL OF MEDICINAL CHEMISTRY, vol. 67, pp. 1611-1623, ISSN:0022-2623
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De Luca, Viviana; Angeli, Andrea; Nocentini, Alessio; Gratteri, Paola; Pratesi, Silvia; Tanini, Damiano; Carginale, Vincenzo; Capperucci, Antonella; Supuran, Claudiu T.; Capasso, Clemente (2024). Leveraging SARS-CoV-2 Main Protease (Mpro) for COVID-19 Mitigation with Selenium-Based Inhibitors. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 25, pp. 0-0, ISSN:1422-0067
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Braconi L.; Riganti C.; Parenti A.; Cecchi M.; Nocentini A.; Bartolucci G.; Menicatti M.; Contino M.; Colabufo N.A.; Manetti D.; Romanelli M.N.; Supuran C.T.; Teodori E. (2024). Dual Inhibitors of P-gp and Carbonic Anhydrase XII (hCA XII) against Tumor Multidrug Resistance with Piperazine Scaffold. MOLECULES, vol. 29, pp. 1-32, ISSN:1420-3049
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Accesso ONLINE all'editore
Giovannuzzi, Simone; Nikitjuka, Anna; Pereira Resende, Bruna Rafaela; Smietana, Michael; Nocentini, Alessio; Supuran, Claudiu T.; Winum, Jean-Yves (2024). Boron-containing carbonic anhydrases inhibitors. BIOORGANIC CHEMISTRY, vol. 143, pp. 0-0, ISSN:0045-2068
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Giovannuzzi, Simone; Chavarria, Daniel; Provensi, Gustavo; Leri, Manuela; Bucciantini, Monica; Carradori, Simone; Bonardi, Alessandro; Gratteri, Paola; Borges, Fernanda; Nocentini, Alessio; Supuran, Claudiu T. (2024). Dual Inhibitors of Brain Carbonic Anhydrases and Monoamine Oxidase-B Efficiently Protect against Amyloid-β-Induced Neuronal Toxicity, Oxidative Stress, and Mitochondrial Dysfunction. JOURNAL OF MEDICINAL CHEMISTRY, vol. 67, pp. 4170-4193, ISSN:0022-2623
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Elsayed, Zainab M; Almahli, Hadia; Nocentini, Alessio; Ammara, Andrea; Supuran, Claudiu T; Eldehna, Wagdy M; Abou-Seri, Sahar M (2023). Development of novel anilinoquinazoline-based carboxylic acids as non-classical carbonic anhydrase IX and XII inhibitors. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 38, pp. 2191163-2191163, ISSN:1475-6366
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Martínez-Montiel, Mónica; Romero-Hernández, Laura L; Giovannuzzi, Simone; Begines, Paloma; Puerta, Adrián; Ahuja-Casarín, Ana I; Fernandes, Miguel X; Merino-Montiel, Penélope; Montiel-Smith, Sara; Nocentini, Alessio; Padrón, José M; Supuran, Claudiu T; Fernández-Bolaños, José G; López, Óscar (2023). Conformationally Restricted Glycoconjugates Derived from Arylsulfonamides and Coumarins: New Families of Tumour-Associated Carbonic Anhydrase Inhibitors. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 24, pp. 0-0, ISSN:1422-0067
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Begines, Paloma; Bonardi, Alessandro; Nocentini, Alessio; Gratteri, Paola; Giovannuzzi, Simone; Ronca, Roberto; Tavani, Camilla; Luisa Massardi, Maria; López, Óscar; Supuran, Claudiu T (2023). Design and synthesis of sulfonamides incorporating a biotin moiety: Carbonic anhydrase inhibitory effects, antiproliferative activity and molecular modeling studies. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 94, pp. 117467-117482, ISSN:0968-0896
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El-Azab, Adel S.; A.-M. Abdel-Aziz, Alaa; Bua, Silvia; Nocentini, Alessio; Bakheit, Ahmed H.; Alkahtani, Hamad M.; Hefnawy, Mohamed M.; Supuran, Claudiu T. (2023). Design, synthesis, and carbonic anhydrase inhibition activities of Schiff bases incorporating benzenesulfonamide scaffold: Molecular docking application. SAUDI PHARMACEUTICAL JOURNAL, vol. 31, pp. 0-0, ISSN:1319-0164
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Ragab, Mahmoud A; Eldehna, Wagdy M; Nocentini, Alessio; Bonardi, Alessandro; Okda, Hazem E; Elgendy, Bahaa; Ibrahim, Tarek S; Abd-Alhaseeb, Mohammad M; Gratteri, Paola; Supuran, Claudiu T; Al-Karmalawy, Ahmed A; Elagawany, Mohamed (2023). 4-(5-Amino-pyrazol-1-yl)benzenesulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and carbonic anhydrase: Design, synthesis, and biological assessments. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 250, pp. 115180-115180, ISSN:0223-5234
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Ialongo, D; Messore, A; Madia, VN; Tudino, V; Nocentini, A; Gratteri, P; Giovannuzzi, S; Supuran, CT; Nicolai, A; Scarpa, S; Taurone, S; Camarda, M; Artico, M; Papa, V; Saccoliti, F; Scipione, L; Di Santo, R; Costi, R (2023). Pyrrolyl and Indolyl alpha-gamma-Diketo Acid Derivatives Acting as Selective Inhibitors of Human Carbonic Anhydrases IX and XII. PHARMACEUTICALS, vol. 16, pp. 188-188, ISSN:1424-8247
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Giovannuzzi, Simone; Bonardi, Alessandro; Gratteri, Paola; Nocentini, Alessio; Supuran, Claudiu T (2023). Discovery of the first-in-class potent and isoform-selective human carbonic anhydrase III inhibitors. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 38, pp. 0-0, ISSN:1475-6374
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Angeli A.; Ferraroni M.; Bonardi A.; Supuran C.T.; Nocentini A. (2023). Diversely N-substituted benzenesulfonamides dissimilarly bind to human carbonic anhydrases: crystallographic investigations of N-nitrosulfonamides. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 38, pp. 2178430-2178430, ISSN:1475-6366
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Ivanova, Jekateri Na; Nocentini, Alessio; Ta Rs, Kaspars; Leita Ns, Ja Nis; Dvinskis, Elviss; Kazaks, Andris; Domračeva, Ilona; Supuran, Claudiu T; Žalubovskis, Raivis (2023). Atropo/Tropo Flexibility: A Tool for Design and Synthesis of Self-Adaptable Inhibitors of Carbonic Anhydrases and Their Antiproliferative Effect. JOURNAL OF MEDICINAL CHEMISTRY, vol. 66, pp. 0-0, ISSN:1520-4804
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Badawi, Waleed A; Rashed, Mahmoud; Nocentini, Alessio; Bonardi, Alessandro; Abd-Alhaseeb, Mohammad M; Al-Rashood, Sara T; Veerakanellore, Giri Babu; Majrashi, Taghreed A; Elkaeed, Eslam B; Elgendy, Bahaa; Gratteri, Paola; Supuran, Claudiu T; Eldehna, Wagdy M; Elagawany, Mohamed (2023). Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 38, pp. 0-0, ISSN:1475-6374
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Accesso ONLINE all'editore
Huwaimel, Bader I; Jonnalagadda, Sravan K; Jonnalagadda, Shirisha; Kumari, Shikha; Nocentini, Alessio; Supuran, Claudiu T; Trippier, Paul C (2023). Selective carbonic anhydrase IX and XII inhibitors based around a functionalized coumarin scaffold. DRUG DEVELOPMENT RESEARCH, pp. 0-0, ISSN:0272-4391
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Ivanova, Jekaterīna; Abdoli, Morteza; Nocentini, Alessio; Žalubovskis, Raivis; Supuran, Claudiu T (2023). Derivatives of 4-methyl-1,2,3-benzoxathiazine 2,2-dioxide as selective inhibitors of human carbonic anhydrases IX and XII over the cytosolic isoforms I and II. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 38, pp. 0-0, ISSN:1475-6366
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Nocentini, Alessio; Capasso, Clemente; Supuran, Claudiu T (2023). Carbonic Anhydrase Inhibitors as Novel Antibacterials in the Era of Antibiotic Resistance: Where Are We Now?. ANTIBIOTICS, vol. 12, pp. 0-0, ISSN:2079-6382
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Ivanova, Jekaterina; Abdoli, Morteza; Nocentini, Alessio; Žalubovskis, Raivis; Supuran, Claudiu T (2023). 1,2,3-Benzoxathiazine-2,2-dioxides - effective inhibitors of human carbonic anhydrases. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 38, pp. 225-238, ISSN:1475-6366
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Nocentini, Alessio; Capasso, Clemente; Supuran, Claudiu T. (2023). Bacterial Ectonucleotidases: Underexplored Antibacterial Drug Targets. In: Alessio Nocentini, Clemente Capasso, Claudiu T Supuran. Bacterial Ectonucleotidases: Underexplored Antibacterial Drug Targets, pp. 0-0 Springer.
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Capasso, Clemente; Nocentini, Alessio; Supuran, Claudiu T. (2023). CD73 Inhibitors as Antitumor Agents. In: Clemente Capasso, Alessio Nocentini, Claudiu T Supuran. Springer, pp. 0-0 Springer.
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Marapaka, Anil Kumar; Nocentini, Alessio; Youse, Molly S; An, Weiwei; Holly, Katrina J; Das, Chittaranjan; Yadav, Ravi; Seleem, Mohamed N; Supuran, Claudiu T; Flaherty, Daniel P (2023). Structural Characterization of Thiadiazolesulfonamide Inhibitors Bound to Neisseria gonorrhoeae α-Carbonic Anhydrase. ACS MEDICINAL CHEMISTRY LETTERS, vol. 14, pp. 103-109, ISSN:1948-5875
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Eldehna, Wagdy M; El Hassab, Mahmoud A; Abdelshafi, Nahla A; Eissa, Rana A; Diab, Nadeen H; Mohamed, Ekram H; Oraby, Mamdouh A; Al-Rashood, Sara T; Eissa, Rana G; Elsayed, Zainab M; Nocentini, Alessio; Supuran, Claudiu T; Elsabahy, Mahmoud; Eissa, Noura G (2023). Development of potent nanosized carbonic anhydrase inhibitor for targeted therapy of hypoxic solid tumors. INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 631, pp. 122537-122537, ISSN:0378-5173
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Fei L, Cantini G, Nocentini A, Nardini P, Catarinicchia S, Canu L, Ercolino T, Quartararo G, Nesi G, Gacci M, Maggi M, Hantel C, Mannelli M, Supuran CT, Luconi M (2023). Carbonic anhydrases III and IX are new players in the crosstalk between adrenocortical carcinoma and its altered adipose microenvironment. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, pp. 1-10, ISSN:0391-4097
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Fiorentino, Francesco; Nocentini, Alessio; Rotili, Dante; Supuran, Claudiu T; Mai, Antonello (2023). Antihistamines, phenothiazine-based antipsychotics, and tricyclic antidepressants potently activate pharmacologically relevant human carbonic anhydrase isoforms II and VII. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 38, pp. 2188147-2188147, ISSN:1475-6374
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El-Damasy, Ashraf K; Kim, Hyun Ji; Nocentini, Alessio; Seo, Seon Hee; Eldehna, Wagdy M; Bang, Eun-Kyoung; Supuran, Claudiu T; Keum, Gyochang (2023). Discovery of new 6-ureido/amidocoumarins as highly potent and selective inhibitors for the tumour-relevant carbonic anhydrases IX and XII. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 38, pp. 2154603-2154603, ISSN:1475-6366
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Cuffaro, Doretta; Di Leo, Riccardo; Ciccone, Lidia; Nocentini, Alessio; Supuran, Claudiu T; Nuti, Elisa; Rossello, Armando (2023). New isoxazolidinyl-based N-alkylethanolamines as new activators of human brain carbonic anhydrases. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 38, pp. 2164574-2164574, ISSN:1475-6366
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Giovannuzzi, Simone; Marapaka, Anil Kumar; Abutaleb, Nader S.; Carta, Fabrizio; Liang, Hsin-Wen; Nocentini, Alessio; Pisano, Luigi; Seleem, Mohamed N.; Flaherty, Daniel P.; Supuran, Claudiu T. (2023). Inhibition of pathogenic bacterial carbonic anhydrases by monothiocarbamates. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 38, pp. 0-0, ISSN:1475-6366
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Romagnoli, Romeo; De Ventura, Tiziano; Manfredini, Stefano; Baldini, Erika; Supuran, Claudiu T.; Nocentini, Alessio; Brancale, Andrea; Bortolozzi, Roberta; Manfreda, Lorenzo; Viola, Giampietro (2023). Design, synthesis, and biological investigation of selective human carbonic anhydrase II, IX, and XII inhibitors using 7-aryl/heteroaryl triazolopyrimidines bearing a sulfanilamide scaffold. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 38, pp. 0-0, ISSN:1475-6366
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Saied, Samaa; Shaldam, Moataz; Elbadawi, Mostafa M.; Giovannuzzi, Simone; Nocentini, Alessio; Almahli, Hadia; Salem, Rofaida; Ibrahim, Tamer M.; Supuran, Claudiu T.; Eldehna, Wagdy M. (2023). Discovery of indolinone-bearing benzenesulfonamides as new dual carbonic anhydrase and VEGFR-2 inhibitors possessing anticancer and pro-apoptotic properties. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 259, pp. 0-0, ISSN:0223-5234
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Elsawi, Ahmed E.; Elbadawi, Mostafa M.; Nocentini, Alessio; Almahli, Hadia; Giovannuzzi, Simone; Shaldam, Moataz; Salem, Rofaida; Ibrahim, Tamer M.; Abdel-Aziz, Hatem A.; Supuran, Claudiu T.; Eldehna, Wagdy M. (2023). 1,5-Diaryl-1,2,4-triazole Ureas as New SLC-0111 Analogues Endowed with Dual Carbonic Anhydrase and VEGFR-2 Inhibitory Activities. JOURNAL OF MEDICINAL CHEMISTRY, vol. 66, pp. 10558-10578, ISSN:0022-2623
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Eldehna, Wagdy M.; Mohammed, Eslam E.; Al-Ansary, Ghada H.; Berrino, Emanuela; Elbadawi, Mostafa M.; Ibrahim, Tamer M.; Jaballah, Maiy Y.; Al-Rashood, Sara T.; Binjubair, Faizah A.; Celik, Meltem; Nocentini, Alessio; Elbarbry, Fawzy A.; Sahin, Fikrettin; Abdel-Aziz, Hatem A.; Supuran, Claudiu T.; Fares, Mohamed (2023). Design and synthesis of 6-arylpyridine-tethered sulfonamides as novel selective inhibitors of carbonic anhydrase IX with promising antitumor features toward the human colorectal cancer. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 258, pp. 0-0, ISSN:0223-5234
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Masci, Domiziana; Puxeddu, Michela; Di Magno, Laura; D’Ambrosio, Michele; Parisi, Anastasia; Nalli, Marianna; Bai, Ruoli; Coluccia, Antonio; Sciò, Pietro; Orlando, Viviana; D’Angelo, Sara; Biagioni, Stefano; Urbani, Andrea; Hamel, Ernest; Nocentini, Alessio; Filiberti, Serena; Turati, Marta; Ronca, Roberto; Kopecka, Joanna; Riganti, Chiara; Fionda, Cinzia; Bordone, Rosa; Della Rocca, Giorgia; Canettieri, Gianluca; Supuran, Claudiu T.; Silvestri, Romano; La Regina, Giuseppe (2023). 4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/β-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells. JOURNAL OF MEDICINAL CHEMISTRY, vol. 66, pp. 14824-14842, ISSN:0022-2623
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Balašova, Anastasija; Pustenko, Aleksandrs; Nocentini, Alessio; Vullo, Daniela; Supuran, Claudiu T.; Žalubovskis, Raivis (2023). Aryl derivatives of 3 H -1,2-benzoxaphosphepine 2-oxides as inhibitors of cancer-related carbonic anhydrase isoforms IX and XII. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 38, pp. 0-0, ISSN:1475-6366
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Nocentini, Alessio; Bonardi, Alessandro; Bazzicalupi, Carla; Alterio, Vincenzo; Esposito, Davide; Monti, Simona Maria; Smietana, Michael; De Simone, Giuseppina; Supuran, Claudiu T; Gratteri, Paola; Winum, Jean-Yves (2023). 6-Substituted Triazolyl Benzoxaboroles as Selective Carbonic Anhydrase Inhibitors: In Silico Design, Synthesis, and X-ray Crystallography. JOURNAL OF MEDICINAL CHEMISTRY, vol. 66, pp. 8118-8129, ISSN:0022-2623
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Accesso ONLINE all'editore
Kumar R.; Kumar A.; Ram S.; Angeli A.; Bonardi A.; Nocentini A.; Gratteri P.; Supuran C.T.; Sharma P.K. (2022). Novel benzenesulfonamide-bearing pyrazoles and 1,2,4-thiadiazoles as selective carbonic anhydrase inhibitors. ARCHIV DER PHARMAZIE, vol. 355, pp. e2100241-e2100241, ISSN:0365-6233
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Accesso ONLINE all'editore
Elimam D.M.; Eldehna W.M.; Salem R.; Bonardi A.; Nocentini A.; Al-Rashood S.T.; Elaasser M.M.; Gratteri P.; Supuran C.T.; Allam H.A. (2022). Natural inspired ligustrazine-based SLC-0111 analogues as novel carbonic anhydrase inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 228, pp. 114008-114019, ISSN:0223-5234
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Accesso ONLINE all'editore
Mussi S.; Rezzola S.; Chiodelli P.; Nocentini A.; Supuran C.T.; Ronca R. (2022). Antiproliferative effects of sulphonamide carbonic anhydrase inhibitors C18, SLC-0111 and acetazolamide on bladder, glioblastoma and pancreatic cancer cell lines. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 280-286, ISSN:1475-6366
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Sharonova, Tatiana; Zhmurov, Petr; Kalinin, Stanislav; Nocentini, Alessio; Angeli, Andrea; Ferraroni, Marta; Korsakov, Mikhail; Supuran, Claudiu T; Krasavin, Mikhail (2022). Diversely substituted sulfamides for fragment-based drug discovery of carbonic anhydrase inhibitors: synthesis and inhibitory profile. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 857-865-865, ISSN:1475-6366
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Fuentes-Aguilar A.; Merino-Montiel P.; Montiel-Smith S.; Meza-Reyes S.; Vega-Baez J.L.; Puerta A.; Fernandes M.X.; Padron J.M.; Petreni A.; Nocentini A.; Supuran C.T.; Lopez O.; Fernandez-Bolanos J.G. (2022). 2-Aminobenzoxazole-appended coumarins as potent and selective inhibitors of tumour-associated carbonic anhydrases. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 168-177, ISSN:1475-6366
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Abutaleb N.S.; Elhassanny A.E.M.; Nocentini A.; Hewitt C.S.; Elkashif A.; Cooper B.R.; Supuran C.T.; Seleem M.N.; Flaherty D.P. (2022). Repurposing FDA-approved sulphonamide carbonic anhydrase inhibitors for treatment of Neisseria gonorrhoeae. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 51-61, ISSN:1475-6366
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Giovannuzzi S.; Abutaleb N.S.; Hewitt C.S.; Carta F.; Nocentini A.; Seleem M.N.; Flaherty D.P.; Supuran C.T. (2022). Dithiocarbamates effectively inhibit the α-carbonic anhydrase from Neisseria gonorrhoeae. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 1-8, ISSN:1475-6366
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Merabti A.; Roger M.; Nguyen C.; Nocentini A.; Gerbier P.; Richeter S.; Gary-Bobo M.; Supuran C.T.; Clement S.; Winum J.-Y. (2022). Carbonic Anhydrase Inhibitors Featuring a Porphyrin Scaffold: Synthesis, Optical and Biological Properties. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, pp. ---, ISSN:1434-193X
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Giovannuzzi S.; D'ambrosio M.; Luceri C.; Osman S.M.; Pallecchi M.; Bartolucci G.; Nocentini A.; Supuran C.T. (2022). Aromatic sulfonamides including a sulfonic acid tail: New membrane impermeant carbonic anhydrase inhibitors for targeting selectively the cancer‐associated isoforms. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, pp. 0-0, ISSN:1661-6596
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Braconi, Laura; Teodori, Elisabetta; Riganti, Chiara; Coronnello, Marcella; Nocentini, Alessio; Bartolucci, Gian Luca; Pallecchi, Marco; Contino, Marialessandra; Manetti, Dina; Romanelli, Maria Novella; Supuran, Claudiu T; Dei, Silvia (2022). New dual P-Glycoprotein (P-gp) and human carbonic anhydrase XII (hCA XII) inhibitors as Multidrug Resistance (MDR) reversers in cancer cells. JOURNAL OF MEDICINAL CHEMISTRY, vol. 65, pp. 14655-14672, ISSN:0022-2623
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Accesso ONLINE all'editore
Arrighi, Giulia; Puerta, Adrián; Petrini, Andrea; Hicke, Francisco J; Nocentini, Alessio; Fernandes, Miguel X; Padrón, José M; Supuran, Claudiu T; Fernández-Bolaños, José G; López, Óscar (2022). Squaramide-Tethered Sulfonamides and Coumarins: Synthesis, Inhibition of Tumor-Associated CAs IX and XII and Docking Simulations. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, pp. 7685-7685, ISSN:1422-0067
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Bonardi, Alessandro; Supuran, Claudiu T.; Nocentini, Alessio (2022). Phenols and Polyphenols as Carbonic Anhydrase Inhibitors. In: Alessandro Bonardi, Claudiu T Supuran, Alessio Nocentini. Phenols and Polyphenols as Carbonic Anhydrase Inhibitors, pp. 330-383 Bentham, ISBN:9789815079098.
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Giovannuzzi, Simone; Capasso, Clemente; Nocentini, Alessio; Supuran, Claudiu T (2022). Continued Structural Exploration of Sulfocoumarin as Selective Inhibitor of Tumor-Associated Human Carbonic Anhydrases IX and XII. MOLECULES, vol. 27, pp. 4076-4076, ISSN:1420-3049
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Bonardi, Alessandro; Micheli, Laura; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Gratteri, Paola; Nocentini, Alessio; Supuran, Claudiu T (2022). Development of Hydrogen Sulfide-Releasing Carbonic Anhydrases IX- and XII-Selective Inhibitors with Enhanced Antihyperalgesic Action in a Rat Model of Arthritis. JOURNAL OF MEDICINAL CHEMISTRY, vol. 65, pp. 13143-13157, ISSN:1520-4804
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Pustenko, Aleksandrs; Balašova, Anastasija; Nocentini, Alessio; Supuran, Claudiu T.; Žalubovskis, Raivis (2022). 3H-1,2-Benzoxaphosphepine 2-oxides as selective inhibitors of carbonic anhydrase IX and XII. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 38, pp. 216-224, ISSN:1475-6366
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Chiaramonte N.; Angeli A.; Sgambellone S.; Bonardi A.; Nocentini A.; Bartolucci G.; Braconi L.; Dei S.; Lucarini L.; Teodori E.; Gratteri P.; Wunsch B.; Supuran C.T.; Romanelli M.N. (2022). 2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 228, pp. 0-0, ISSN:0223-5234
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Mostafa M. Elbadawi; Wagdy M. Eldehna; Alessio Nocentini; Warda R. Somaa; Sara T. Al-Rashood; Eslam B. Elkaeed; Mahmoud A. El Hassab; Hatem A. Abdel-Aziz; Claudiu T. Supuran; Mohamed Fares (2022). Development of 4-((3-oxo-3-phenylpropyl)amino)benzenesulfonamide derivatives utilizing tail/dual-tail approaches as novel carbonic anhydrase inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 238, pp. 114412-114412, ISSN:0223-5234
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Al-Warhi, Tarfah; Elbadawi, Mostafa M; Bonardi, Alessandro; Nocentini, Alessio; Al-Karmalawy, Ahmed A; Aljaeed, Nada; Alotaibi, Ohoud J; Abdel-Aziz, Hatem A; Supuran, Claudiu T; Eldehna, Wagdy M (2022). Design and synthesis of benzothiazole-based SLC-0111 analogues as new inhibitors for the cancer-associated carbonic anhydrase isoforms IX and XII. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 2635-2643, ISSN:1475-6374
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Beatriz Vermelho, Alane; Rodrigues, Giseli Capaci; Nocentini, Alessio; Mansoldo, Felipe R P; Supuran, Claudiu T (2022). Discovery of novel drugs for Chagas disease: is carbonic anhydrase a target for antiprotozoal drugs?. EXPERT OPINION ON DRUG DISCOVERY, vol. 17, pp. 1147-1158, ISSN:1746-045X
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Ibrahim, Hany S; Abdelrahman, Mohamed A; Nocentini, Alessio; Bua, Silvia; Abdel-Aziz, Hatem A; Supuran, Claudiu T; Abou-Seri, Sahar M; Eldehna, Wagdy M (2022). Insights into the effect of elaborating coumarin-based aryl enaminones with sulfonamide or carboxylic acid functionality on carbonic anhydrase inhibitory potency and selectivity. BIOORGANIC CHEMISTRY, vol. 126, pp. 105888-105888, ISSN:0045-2068
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Abo-Ashour, Mahmoud F; Almahli, Hadia; Bonardia, Alessandro; Khalil, Amira; Al-Warhi, Tarfah; Al-Rashood, Sara T; Abdel-Aziz, Hatem A; Nocentini, Alessio; Supuran, Claudiu T; Eldehna, Wagdy M (2022). Enaminone-based carboxylic acids as novel non-classical carbonic anhydrases inhibitors: design, synthesis and in vitro biological assessment. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 2256-2264, ISSN:1475-6374
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Kalinin, Stanislav; Kovalenko, Alexander; Valtari, Annika; Nocentini, Alessio; Gureev, Maxim; Urtti, Arto; Korsakov, Mikhail; Supuran, Claudiu T; Krasavin, Mikhail (2022). 5-(Sulfamoyl)thien-2-yl 1,3-oxazole inhibitors of carbonic anhydrase II with hydrophilic periphery. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 1005-1011, ISSN:1475-6374
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Arias, Hugo R; Borghese, Cecilia M; Germann, Allison L; Pierce, Spencer R; Bonardi, Alessandro; Nocentini, Alessio; Gratteri, Paola; Thodati, Thanvi M; Lim, Natalie J; Harris, R Adron; Akk, Gustav (2022). (+)-Catharanthine potentiates the GABAA receptor by binding to a transmembrane site at the β(+)/α(-) interface near the TM2-TM3 loop. BIOCHEMICAL PHARMACOLOGY, vol. 199, pp. 114993-114993, ISSN:1873-2968
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Tawfik, Haytham O; Shaldam, Moataz A; Nocentini, Alessio; Salem, Rofaida; Almahli, Hadia; Al-Rashood, Sara T; Supuran, Claudiu T; Eldehna, Wagdy M (2022). Novel 3-(6-methylpyridin-2-yl)coumarin-based chalcones as selective inhibitors of cancer-related carbonic anhydrases IX and XII endowed with anti-proliferative activity. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 1043-1052, ISSN:1475-6374
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Huwaimel, Bader I; Jonnalagadda, Sravan; Jonnalagadda, Shirisha; Zahra, Fatema T; Nocentini, Alessio; Supuran, Claudiu T; Mikelis, Constantinos M; Trippier, Paul C (2022). Chlorinated benzothiadiazines inhibit angiogenesis through suppression of VEGFR2 phosphorylation. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 67, pp. 116805-116805, ISSN:1464-3391
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Yusuf, Zainab Saad; Uysal, Tugba Kevser; Simsek, Ender; Nocentini, Alessio; Osman, Sameh Mohamed; Supuran, Claudiu T; Özensoy Güler, Özen (2022). The inhibitory effect of boric acid on hypoxia-regulated tumour-associated carbonic anhydrase IX. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 1340-1345, ISSN:1475-6374
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El-Azab, Adel S.; Abdel-Aziz, Alaa A.-M.; Ghabbour, Hazem A.; Bua, Silvia; Nocentini, Alessio; Alkahtani, Hamad M.; Alsaif, Nawaf A.; Al-Agamy, Mohamed H. M.; Supuran, Claudiu T. (2022). Carbonic Anhydrase Inhibition Activities of Schiff’s Bases Based on Quinazoline-Linked Benzenesulfonamide. MOLECULES, vol. 27, pp. 7703-7703, ISSN:1420-3049
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Di Fiore, Anna; De Luca, Viviana; Langella, Emma; Nocentini, Alessio; Buonanno, Martina; Monti, Simona Maria; Supuran, Claudiu T; Capasso, Clemente; De Simone, Giuseppina (2022). Biochemical, structural, and computational studies of a γ-carbonic anhydrase from the pathogenic bacterium Burkholderia pseudomallei. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, vol. 20, pp. 4185-4194, ISSN:2001-0370
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An, Weiwei; Holly, Katrina J; Nocentini, Alessio; Imhoff, Ryan D; Hewitt, Chad S; Abutaleb, Nader S; Cao, Xufeng; Seleem, Mohamed N; Supuran, Claudiu T; Flaherty, Daniel P (2022). Structure-activity relationship studies for inhibitors for vancomycin-resistant Enterococcus and human carbonic anhydrases. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 1838-1844, ISSN:1475-6374
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Gurgone, Antonia; Pizzo, Riccardo; Raspanti, Alessandra; Chiantia, Giuseppe; Devi, Sunaina; Comai, Debora; Morello, Noemi; Pilotto, Federica; Gnavi, Sara; Lupori, Leonardo; Mazziotti, Raffaele; Sagona, Giulia; Putignano, Elena; Nocentini, Alessio; Supuran, Claudiu T; Marcantoni, Andrea; Pizzorusso, Tommaso; Giustetto, Maurizio (2022). mGluR5 PAMs rescue cortical and behavioural defects in a mouse model of CDKL5 deficiency disorder. NEUROPSYCHOPHARMACOLOGY, pp. 0-0, ISSN:1740-634X
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Yrjanainen A.; Patrikainen M.S.; Azizi L.; Tolvanen M.E.E.; Laitaoja M.; Janis J.; Hytonen V.P.; Nocentini A.; Supuran C.T.; Parkkila S. (2022). Biochemical and Biophysical Characterization of Carbonic Anhydrase VI from Human Milk and Saliva. PROTEIN JOURNAL, vol. 41, pp. 489-503, ISSN:1572-3887
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Cirri, Damiano; Bazzicalupi, Carla; Ryde, Ulf; Bergmann, Justin; Binacchi, Francesca; Nocentini, Alessio; Pratesi, Alessandro; Gratteri, Paola; Messori, Luigi (2022). Computationally enhanced X-ray diffraction analysis of a gold(III) complex interacting with the human telomeric DNA G-quadruplex. Unravelling non-unique ligand positioning. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, vol. 211, pp. 506-513, ISSN:0141-8130
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Giovannuzzi S.; De Luca V.; Nocentini A.; Capasso C.; Supuran C.T. (2022). Coumarins inhibit η-class carbonic anhydrase from Plasmodium falciparum. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 680-685, ISSN:1475-6366
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Bonardi, Alessandro; Bua, Silvia; Combs, Jacob; Lomelino, Carrie; Andring, Jacob; Osman, Sameh Mohamed; Toti, Alessandra; Di Cesare Mannelli, Lorenzo; Gratteri, Paola; Ghelardini, Carla; McKenna, Robert; Nocentini, Alessio; Supuran, Claudiu T (2022). The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 930-939-939, ISSN:1475-6366
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Eldehna W.M.; Taghour M.S.; Al-Warhi T.; Nocentini A.; Elbadawi M.M.; Mahdy H.A.; Abdelrahman M.A.; Alotaibi O.J.; Aljaeed N.; Elimam D.M.; Afarinkia K.; Abdel-Aziz H.A.; Supuran C.T. (2022). Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 531-541, ISSN:1475-6366
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Giovannuzzi S.; Hewitt C.S.; Nocentini A.; Capasso C.; Flaherty D.P.; Supuran C.T. (2022). Coumarins effectively inhibit bacterial α-carbonic anhydrases. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 333-338, ISSN:1475-6366
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Giovannuzzi S.; Hewitt C.S.; Nocentini A.; Capasso C.; Costantino G.; Flaherty D.P.; Supuran C.T. (2022). Inhibition studies of bacterial α-carbonic anhydrases with phenols. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 666-671, ISSN:1475-6366
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Nocentini, Alessio; Capasso, Clemente; Supuran, Claudiu T (2022). Perspectives on the design and discovery of α-ketoamide inhibitors for the treatment of novel coronavirus: where do we stand and where do we go?. EXPERT OPINION ON DRUG DISCOVERY, pp. 1-11-11, ISSN:1746-0441
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Nocentini A.; Bonardi A.; Pratesi S.; Gratteri P.; Dani C.; Supuran C.T. (2022). Pharmaceutical strategies for preventing toxicity and promoting antioxidant and anti-inflammatory actions of bilirubin. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 487-501, ISSN:1475-6366
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Sbravati D.; Bonardi A.; Bua S.; Angeli A.; Ferraroni M.; Nocentini A.; Casnati A.; Gratteri P.; Sansone F.; Supuran C.T. (2022). Calixarenes Incorporating Sulfonamide Moieties: Versatile Ligands for Carbonic Anhydrases Inhibition. CHEMISTRY-A EUROPEAN JOURNAL, vol. 28, pp. 1-8, ISSN:0947-6539
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Ismail C.; Nocentini A.; Supuran C.T.; Winum J.-Y.; Gharbi R. (2022). 1,5-Benzodiazepines as a platform for the design of carbonic anhydrase inhibitors. ARCHIV DER PHARMAZIE, vol. 355, pp. e2100405-e2100405, ISSN:0365-6233
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Elbadawi M.M.; Eldehna W.M.; Nocentini A.; Abo-Ashour M.F.; Elkaeed E.B.; Abdelgawad M.A.; Alharbi K.S.; Abdel-Aziz H.A.; Supuran C.T.; Gratteri P.; Al-Sanea M.M. (2021). Identification of N-phenyl-2-(phenylsulfonyl)acetamides/propanamides as new SLC-0111 analogues: Synthesis and evaluation of the carbonic anhydrase inhibitory activities. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 218, pp. 113360-113371, ISSN:0223-5234
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Grande R.; Carradori S.; Puca V.; Vitale I.; Angeli A.; Nocentini A.; Bonardi A.; Gratteri P.; Lanuti P.; Bologna G.; Simeone P.; Capasso C.; De Luca V.; Supuran C.T. (2021). Selective inhibition of helicobacter pylori carbonic anhydrases by carvacrol and thymol could impair biofilm production and the release of outer membrane vesicles. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, pp. 11583-11603, ISSN:1661-6596
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Nocentini, Alessio; Vermelho, Alane B.; Supuran, Claudiu T. (2021). Targeting Carbonic Anhydrases from Trypanosoma cruzi and Leishmania spp. as a Therapeutic Strategy to Obtain New Antiprotozoal Drugs. In: Alane B. Vermelho, Claudiu T. Supuran. Topics in Medicinal Chemistry, pp. 1-29 Springer.
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Hewitt C.S.; Abutaleb N.S.; Elhassanny A.E.M.; Nocentini A.; Cao X.; Amos D.P.; Youse M.S.; Holly K.J.; Marapaka A.K.; An W.; Kaur J.; Krabill A.D.; Elkashif A.; Elgammal Y.; Graboski A.L.; Supuran C.T.; Seleem M.N.; Flaherty D.P. (2021). Structure-Activity Relationship Studies of Acetazolamide-Based Carbonic Anhydrase Inhibitors with Activity against Neisseria gonorrhoeae. ACS INFECTIOUS DISEASES, vol. 7, pp. 1969-1984, ISSN:2373-8227
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Elimam D.M.; Elgazar A.A.; Bonardi A.; Abdelfadil M.; Nocentini A.; El-Domany R.A.; Abdel-Aziz H.A.; Badria F.A.; Supuran C.T.; Eldehna W.M. (2021). Natural inspired piperine-based sulfonamides and carboxylic acids as carbonic anhydrase inhibitors: Design, synthesis and biological evaluation. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 225, pp. 113800--, ISSN:0223-5234
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Sharonova T.; Paramonova P.; Kalinin S.; Bunev A.; Gasanov R.Е.; Nocentini A.; Sharoyko V.; Tennikova T.B.; Dar'in D.; Supuran C.T.; Krasavin M. (2021). Insertion of metal carbenes into the anilinic N–H bond of unprotected aminobenzenesulfonamides delivers low nanomolar inhibitors of human carbonic anhydrase IX and XII isoforms. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 218, pp. 113352--, ISSN:0223-5234
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Alterio V.; Langella E.; Buonanno M.; Esposito D.; Nocentini A.; Berrino E.; Bua S.; Polentarutti M.; Supuran C.T.; Monti S.M.; De Simone G. (2021). Zeta-carbonic anhydrases show CS2 hydrolase activity: A new metabolic carbon acquisition pathway in diatoms?. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, vol. 19, pp. 3427-3436, ISSN:2001-0370
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Petreni A.; Osman S.M.; Alasmary F.A.; Almutairi T.M.; Nocentini A.; Supuran C.T. (2021). Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 226, pp. 113875--, ISSN:0223-5234
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Biernacki K.; Ciupak O.; Dasko M.; Rachon J.; Kozak W.; Rak J.; Kubinski K.; Maslyk M.; Martyna A.; Sliwka-Kaszynska M.; Wietrzyk J.; Switalska M.; Nocentini A.; Supuran C.T.; Demkowicz S. (2021). Development of Sulfamoylated 4-(1-Phenyl-1 H-1,2,3-triazol-4-yl)phenol Derivatives as Potent Steroid Sulfatase Inhibitors for Efficient Treatment of Breast Cancer. JOURNAL OF MEDICINAL CHEMISTRY, vol. 65, pp. 5044-5056, ISSN:0022-2623
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Odi R.; Bibi D.; Shusterman B.; Erenburg N.; Shaul C.; Supuran C.T.; Nocentini A.; Bialer M. (2021). Synthesis and enantioselective pharmacokinetic/ pharmacodynamic analysis of new CNS-active sulfamoylphenyl carbamate derivatives. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, pp. 3361--, ISSN:1661-6596
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Nocentini A.; Hewitt C.S.; Mastrolorenzo M.D.; Flaherty D.P.; Supuran C.T. (2021). Anion inhibition studies of the α-carbonic anhydrases from Neisseria gonorrhoeae. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 36, pp. 1061-1066, ISSN:1475-6366
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Petreni A.; De Luca V.; Scaloni A.; Nocentini A.; Capasso C.; Supuran C.T. (2021). Anion inhibition studies of the Zn(II)-bound ι-carbonic anhydrase from the Gram-negative bacterium Burkholderia territorii. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 36, pp. 372-376, ISSN:1475-6366
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De Luca V.; Petreni A.; Nocentini A.; Scaloni A.; Supuran C.T.; Capasso C. (2021). Effect of sulfonamides and their structurally related derivatives on the activity of ι-carbonic anhydrase from burkholderia territorii. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, pp. 1-13, ISSN:1661-6596
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Shaldam M.; Nocentini A.; Elsayed Z.M.; Ibrahim T.M.; Salem R.; El-Domany R.A.; Capasso C.; Supuran C.T.; Eldehna W.M. (2021). Development of novel quinoline-based sulfonamides as selective cancer-associated carbonic anhydrase isoform ix inhibitors. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, pp. 11119--, ISSN:1661-6596
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Capasso C.; Nocentini A.; Supuran C.T. (2021). Protease inhibitors targeting the main protease and papain-like protease of coronaviruses. EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 31, pp. 309-324, ISSN:1354-3776
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Nocentini A.; Capasso C.; Supuran C.T. (2021). Small-molecule CD73 inhibitors for the immunotherapy of cancer: a patent and literature review (2017–present). EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 31, pp. 867-876, ISSN:1354-3776
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Luchinat, Enrico; Barbieri, Letizia; Cremonini, Matteo; Pennestri, Matteo; Nocentini, Alessio; Supuran, Claudiu T; Banci, Lucia (2021). Determination of intracellular protein-ligand binding affinity by competition binding in-cell NMR. ACTA CRYSTALLOGRAPHICA. SECTION D, STRUCTURAL BIOLOGY, vol. 77, pp. 1270-1281, ISSN:2059-7983
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Shaldam M.; Eldehna W.M.; Nocentini A.; Elsayed Z.M.; Ibrahim T.M.; Salem R.; El-Domany R.A.; Capasso C.; Abdel-Aziz H.A.; Supuran C.T. (2021). Development of novel benzofuran-based SLC-0111 analogs as selective cancer-associated carbonic anhydrase isoform IX inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 216, pp. 113283--, ISSN:0223-5234
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Mincione F.; Nocentini A.; Supuran C.T. (2021). Advances in the discovery of novel agents for the treatment of glaucoma. EXPERT OPINION ON DRUG DISCOVERY, vol. 16, pp. 1209-1225, ISSN:1746-0441
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Mueller S.L.; Chrysanthopoulos P.K.; Halili M.A.; Hepburn C.; Nebl T.; Supuran C.T.; Nocentini A.; Peat T.S.; Poulsen S.-A. (2021). The glitazone class of drugs as carbonic anhydrase inhibitors—a spin-off discovery from fragment screening. MOLECULES, vol. 26, pp. 3010--, ISSN:1420-3049
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Eldeeb A.H.; Abo-Ashour M.F.; Angeli A.; Bonardi A.; Lasheen D.S.; Elrazaz E.Z.; Nocentini A.; Gratteri P.; Abdel-Aziz H.A.; Supuran C.T. (2021). Novel benzenesulfonamides aryl and arylsulfone conjugates adopting tail/dual tail approaches: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 221, pp. 113486-113509, ISSN:0223-5234
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Bonardi A.; Nocentini A.; Osman S.M.; Alasmary F.A.; Almutairi T.M.; Abdullah D.S.; Gratteri P.; Supuran C.T. (2021). Inhibition of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae with aromatic sulphonamides and clinically licenced drugs–a joint docking/molecular dynamics study. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 36, pp. 469-479, ISSN:1475-6366
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Bouzina A.; Berredjem M.; Nocentini A.; Bua S.; Bouaziz Z.; Jose J.; Le Borgne M.; Marminon C.; Gratteri P.; Supuran C.T. (2021). Ninhydrins inhibit carbonic anhydrases directly binding to the metal ion. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 209, pp. 112875-112882, ISSN:0223-5234
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Abdelrahman M.A.; Ibrahim H.S.; Nocentini A.; Eldehna W.M.; Bonardi A.; Abdel-Aziz H.A.; Gratteri P.; Abou-Seri S.M.; Supuran C.T. (2021). Novel 3-substituted coumarins as selective human carbonic anhydrase IX and XII inhibitors: Synthesis, biological and molecular dynamics analysis. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 209, pp. 0-0, ISSN:0223-5234
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Gustavo Provensi; Alessio Nocentini; Maria Beatrice Passani; Patrizio Blandina; Claudiu T Supuran (2021). Activation of carbonic anhydrase isoforms involved in modulation of emotional memory and cognitive disorders with histamine agonists, antagonists and derivatives. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 36, pp. 719-726, ISSN:1475-6374
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Bulli I.; Dettori I.; Coppi E.; Cherchi F.; Venturini M.; Mannelli L.D.C.; Ghelardini C.; Nocentini A.; Supuran C.T.; Pugliese A.M.; Pedata F. (2021). Role of carbonic anhydrase in cerebral ischemia and carbonic anhydrase inhibitors as putative protective agents. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, pp. 5029-5038, ISSN:1661-6596
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Lucarini E., Nocentini A., Bonardi A., Chiaramonte N., Parisio C., Micheli L., Toti A., Ferrara V., Carrino D., Pacini A., Romanelli M.N., Supuran C.T., Ghelardini C., Di Cesare Mannelli L. (2021). Carbonic Anhydrase IV Selective Inhibitors Counteract the Development of Colitis-Associated Visceral Pain in Rats. CELLS, vol. 10, pp. 2540-2555, ISSN:2073-4409
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Angeli A.; Carta F.; Nocentini A.; Winum J.-Y.; Zalubovskis R.; Onnis V.; Eldehna W.M.; Capasso C.; Carradori S.; Donald W.A.; Dedhar S.; Supuran C.T. (2021). Response to Perspectives on the Classical Enzyme Carbonic Anhydrase and the Search for Inhibitors. BIOPHYSICAL JOURNAL, vol. 120, pp. 178-181, ISSN:0006-3495
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Dettori I.; Fusco I.; Bulli I.; Gaviano L.; Coppi E.; Cherchi F.; Venturini M.; Di Cesare Mannelli L.; Ghelardini C.; Nocentini A.; Supuran C.T.; Pugliese A.M.; Pedata F. (2021). Protective effects of carbonic anhydrase inhibition in brain ischaemia in vitro and in vivo models. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 36, pp. 964-976, ISSN:1475-6366
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Dar'in D.; Kantin G.; Kalinin S.; Sharonova T.; Bunev A.; Ostapenko G.I.; Nocentini A.; Sharoyko V.; Supuran C.T.; Krasavin M. (2021). Investigation of 3-sulfamoyl coumarins against cancer-related IX and XII isoforms of human carbonic anhydrase as well as cancer cells leads to the discovery of 2-oxo-2H-benzo[h]chromene-3-sulfonamide – A new caspase-activating proapoptotic agent. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 222, pp. 113589--, ISSN:0223-5234
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Supuran C.T.; Nocentini A.; Yakubova E.; Savchuk N.; Kalinin S.; Krasavin M. (2021). Biochemical profiling of anti-HIV prodrug Elsulfavirine (Elpida®) and its active form VM1500A against a panel of twelve human carbonic anhydrase isoforms. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 36, pp. 1056-1060, ISSN:1475-6366
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Yassine Aimene; Romain Eychenne; Fr??d??ric Rodriguez; Sonia Mallet-Ladeira; Nathalie Saffon-Merceron; Jean-Yves Winum; Alessio Nocentini; Claudiu T. Supuran; Eric Benoist; Achour Seridi (2021). Synthesis, Crystal Structure, Inhibitory Activity and Molecular Docking of Coumarins/Sulfonamides Containing Triazolyl Pyridine Moiety as Potent Selective Carbonic Anhydrase IX and XII Inhibitors. CRYSTALS, vol. 11, pp. 1076-1076, ISSN:2073-4352
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Bonardi Alessandro, Nocentini Alessio, Gratteri Paola, Supuran Claudiu Trandafir (2021). In silico strategies for the rational design, synthesis, and biological evaluation of ligands targeting macromolecules of pharmaceutical interest. (Tutor: Prof.ssa Paola Gratteri, Prof. Claudiu T. Supuran)
Nocentini A.; Cuffaro D.; Ciccone L.; Orlandini E.; Nencetti S.; Nuti E.; Rossello A.; Supuran C.T. (2021). Activation of carbonic anhydrases from human brain by amino alcohol oxime ethers: towards human carbonic anhydrase VII selective activators. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 36, pp. 48-57, ISSN:1475-6366
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Nocentini A.; Supuran C.T.; Capasso C. (2021). An overview on the recently discovered iota-carbonic anhydrases. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 36, pp. 1988-1995, ISSN:1475-6366
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Nocentini, Alessio; Angeli, Andrea; Carta, Fabrizio; Winum, Jean-Yves; Zalubovskis, Raivis; Carradori, Simone; Capasso, Clemente; Donald, William A; Supuran, Claudiu T (2021). Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 36, pp. 561-580, ISSN:1475-6366
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Nocentini, Alessio; Fais, Stefano (2021). Proton pump inhibitors and other pH-buffering agents. In: Claudiu T. Supuran, Simone Carradori. pH-Interfering Agents as Chemosensitizers in Cancer Therapy, pp. 47-62 Elsevier, ISBN:9780128207017.
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La Regina G.; Puxeddu M.; Nalli M.; Vullo D.; Gratteri P.; Supuran C.T.; Nocentini A.; Silvestri R. (2020). Discovery of New 1,1′-Biphenyl-4-sulfonamides as Selective Subnanomolar Human Carbonic Anhydrase II Inhibitors. ACS MEDICINAL CHEMISTRY LETTERS, vol. 11, pp. 633-637, ISSN:1948-5875
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Del Prete S.; De Luca V.; De Luca V.; Nocentini A.; Scaloni A.; Mastrolorenzo M.D.; Mastrolorenzo M.D.; Supuran C.T.; Capasso C. (2020). Anion inhibition studies of the beta-carbonic anhydrase from Escherichia coli. MOLECULES, vol. 25, pp. 2564--, ISSN:1420-3049
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Eldehna W.M.; Eldehna W.M.; Nocentini A.; Elsayed Z.M.; Al-Warhi T.; Aljaeed N.; Alotaibi O.J.; Al-Sanea M.M.; Abdel-Aziz H.A.; Supuran C.T. (2020). Benzofuran-Based Carboxylic Acids as Carbonic Anhydrase Inhibitors and Antiproliferative Agents against Breast Cancer. ACS MEDICINAL CHEMISTRY LETTERS, vol. 11, pp. 1022-1027, ISSN:1948-5875
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Jin S.; Vullo D.; Bua S.; Nocentini A.; Supuran C.T.; Gao Y.-G. (2020). Structural and biochemical characterization of novel carbonic anhydrases from Phaeodactylum tricornutum Jin Shengyang. ACTA CRYSTALLOGRAPHICA. SECTION D, STRUCTURAL BIOLOGY, vol. 76, pp. 676-686, ISSN:2059-7983
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Petreni A.; Bonardi A.; Lomelino C.; Osman S.M.; ALOthman Z.A.; Eldehna W.M.; El-Haggar R.; McKenna R.; Nocentini A.; Supuran C.T. (2020). Inclusion of a 5-fluorouracil moiety in nitrogenous bases derivatives as human carbonic anhydrase IX and XII inhibitors produced a targeted action against MDA-MB-231 and T47D breast cancer cells. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 190, pp. 112112--, ISSN:0223-5234
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Grandane A.; Nocentini A.; Werner T.; Zalubovskis R.; Supuran C.T. (2020). Benzoxepinones: A new isoform-selective class of tumor associated carbonic anhydrase inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 28, pp. 115496--, ISSN:0968-0896
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Nocentini A.; Moi D.; Deplano A.; Osman S.M.; AlOthman Z.A.; Balboni G.; Supuran C.T.; Onnis V. (2020). Sulfonamide/sulfamate switch with a series of piperazinylureido derivatives: Synthesis, kinetic and in silico evaluation as carbonic anhydrase isoforms I, II, IV, and IX inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 186, pp. 111896--, ISSN:0223-5234
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Moi D.; Nocentini A.; Deplano A.; Osman S.M.; AlOthman Z.A.; Piras V.; Balboni G.; Supuran C.T.; Onnis V. (2020). Appliance of the piperidinyl-hydrazidoureido linker to benzenesulfonamide compounds: Synthesis, in vitro and in silico evaluation of potent carbonic anhydrase II, IX and XII inhibitors. BIOORGANIC CHEMISTRY, vol. 98, pp. 103728--, ISSN:0045-2068
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Grandane A.; Nocentini A.; Domraceva I.; Zalubovskis R.; Supuran C.T. (2020). Development of oxathiino[6,5-b]pyridine 2,2-dioxide derivatives as selective inhibitors of tumor-related carbonic anhydrases IX and XII. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 200, pp. 112300--, ISSN:0223-5234
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El-Azab A.S.; Abdel-Aziz A.A.-M.; Bua S.; Nocentini A.; AlSaif N.A.; Alanazi M.M.; El-Gendy M.A.; Ahmed H.E.A.; Supuran C.T. (2020). S-substituted 2-mercaptoquinazolin-4(3H)-one and 4-ethylbenzensulfonamides act as potent and selective human carbonic anhydrase IX and XII inhibitors. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 733-743, ISSN:1475-6366
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Alissa S.A.; Alghulikah H.A.; ALOthman Z.A.; Osman S.M.; Del Prete S.; Capasso C.; Nocentini A.; Supuran C.T. (2020). Inhibition survey with phenolic compounds against the δ- and η-class carbonic anhydrases from the marine diatom thalassiosira weissflogii and protozoan Plasmodium falciparum. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 377-382, ISSN:1475-6366
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Abdelrahman M.A.; Eldehna W.M.; Nocentini A.; Ibrahim H.S.; Almahli H.; Abdel-Aziz H.A.; Abou-Seri S.M.; Supuran C.T. (2020). Novel benzofuran-based sulphonamides as selective carbonic anhydrases IX and XII inhibitors: synthesis and in vitro biological evaluation. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 298-305, ISSN:1475-6366
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Irfan A.; Batool F.; Zahra Naqvi S.A.; Islam A.; Osman S.M.; Nocentini A.; Alissa S.A.; Supuran C.T. (2020). Benzothiazole derivatives as anticancer agents. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 265-279, ISSN:1475-6366
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Del Prete S.; Nocentini A.; Supuran C.T.; Capasso C. (2020). Bacterial ι-carbonic anhydrase: a new active class of carbonic anhydrase identified in the genome of the Gram-negative bacterium Burkholderia territorii. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 1060-1068, ISSN:1475-6366
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Oguz M.; Kalay E.; Akocak S.; Nocentini A.; Lolak N.; Boga M.; Yilmaz M.; Supuran C.T. (2020). Synthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory action. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 1215-1223, ISSN:1475-6366
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Anduran E.; Aspatwar A.; Parvathaneni N.-K.; Suylen D.; Bua S.; Nocentini A.; Parkkila S.; Supuran C.T.; Dubois L.; Lambin P.; Winum J.-Y. (2020). Hypoxia-activated prodrug derivatives of carbonic anhydrase inhibitors in benzenesulfonamide series: Synthesis and biological evaluation. MOLECULES, vol. 25, pp. 2347--, ISSN:1420-3049
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Prete S.D.; De Luca V.; Bua S.; Nocentini A.; Carginale V.; Supuran C.T.; Capasso C. (2020). The effect of substituted benzene-sulfonamides and clinically licensed drugs on the catalytic activity of cynt2, a carbonic anhydrase crucial for escherichia coli life cycle. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, pp. 1-14, ISSN:1661-6596
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Bua S.; Lucarini L.; Micheli L.; Menicatti M.; Bartolucci G.; Selleri S.; Di Cesare Mannelli L.; Ghelardini C.; Masini E.; Carta F.; Gratteri P.; Nocentini A.; Supuran C.T. (2020). Bioisosteric Development of Multitarget Nonsteroidal Anti-Inflammatory Drug-Carbonic Anhydrases Inhibitor Hybrids for the Management of Rheumatoid Arthritis. JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, pp. 2325-2342, ISSN:0022-2623
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Alissa S.A.; Alghulikah H.A.; Alothman Z.A.; Osman S.M.; Del Prete S.; Capasso C.; Nocentini A.; Supuran C.T. (2020). Phosphonamidates are the first phosphorus-based zinc binding motif to show inhibition of β-class carbonic anhydrases from bacteria, fungi, and protozoa. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 59-64, ISSN:1475-6366
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Bua S.; Lomelino C.; Murray A.B.; Osman S.M.; Alothman Z.A.; Bozdag M.; Abdel-Aziz H.A.; Eldehna W.M.; McKenna R.; Nocentini A.; Supuran C.T. (2020). "a Sweet Combination": Developing Saccharin and Acesulfame K Structures for Selectively Targeting the Tumor-Associated Carbonic Anhydrases IX and XII. JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, pp. 321-333, ISSN:0022-2623
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Clima L.; Craciun B.F.; Angeli A.; Petreni A.; Bonardi A.; Nocentini A.; Carta F.; Gratteri P.; Pinteala M.; Supuran C.T. (2020). Synthesis, Computational Studies and Assessment of in Vitro Activity of Squalene Derivatives as Carbonic Anhydrase Inhibitors. CHEMMEDCHEM, vol. 15, pp. 2052-2057, ISSN:1860-7179
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Angeli A.; Carta F.; Nocentini A.; Winum J.-Y.; Zalubovskis R.; Akdemir A.; Onnis V.; Eldehna W.M.; Capasso C.; Simone G.D.; Monti S.M.; Carradori S.; Donald W.A.; Dedhar S.; Supuran C.T. (2020). Carbonic anhydrase inhibitors targeting metabolism and tumor microenvironment. METABOLITES, vol. 10, pp. 1-21, ISSN:2218-1989
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Bonardi A.; Nocentini A.; Cadoni R.; Del Prete S.; Dumy P.; Capasso C.; Gratteri P.; Supuran C.T.; Winum J.-Y. (2020). Benzoxaboroles: New Potent Inhibitors of the Carbonic Anhydrases of the Pathogenic Bacterium Vibrio cholerae. ACS MEDICINAL CHEMISTRY LETTERS, vol. 11, pp. 2277-2284, ISSN:1948-5875
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Bonardi A.; Nocentini A.; Bua S.; Combs J.; Lomelino C.; Andring J.; Lucarini L.; Sgambellone S.; Masini E.; McKenna R.; Gratteri P.; Supuran C.T. (2020). Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action. JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, pp. 7422-7444, ISSN:0022-2623
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Guglielmi P.; Rotondi G.; Secci D.; Angeli A.; Chimenti P.; Nocentini A.; Bonardi A.; Gratteri P.; Carradori S.; Supuran C.T. (2020). Novel insights on saccharin- and acesulfame-based carbonic anhydrase inhibitors: design, synthesis, modelling investigations and biological activity evaluation. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 1891-1905, ISSN:1475-6366
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Alkhaldi A.A.M.; Al-Sanea M.M.; Nocentini A.; Eldehna W.M.; Elsayed Z.M.; Bonardi A.; Abo-Ashour M.F.; El-Damasy A.K.; Abdel-Maksoud M.S.; Al-Warhi T.; Gratteri P.; Abdel-Aziz H.A.; Supuran C.T.; El-Haggar R. (2020). 3-Methylthiazolo[3,2-a]benzimidazole-benzenesulfonamide conjugates as novel carbonic anhydrase inhibitors endowed with anticancer activity: Design, synthesis, biological and molecular modeling studies. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 207, pp. 0-0, ISSN:0223-5234
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Picci G.; Bazzicalupi C.; Coles S.J.; Gratteri P.; Isaia F.; Lippolis V.; Montis R.; Murgia S.; Nocentini A.; Orton J.B.; Caltagirone C. (2020). Halogenated isophthalamides and dipicolineamides: The role of the halogen substituents in the anion binding properties. DALTON TRANSACTIONS, vol. 49, pp. 9231-9238, ISSN:1477-9226
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Zoppi C.; Nocentini A.; Supuran C.T.; Pratesi A.; Messori L. (2020). Native mass spectrometry of human carbonic anhydrase I and its inhibitor complexes. JBIC, pp. 1-15, ISSN:0949-8257
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Luchinat E.; Barbieri L.; Cremonini M.; Nocentini A.; Supuran C.T.; Banci L. (2020). Drug Screening in Human Cells by NMR Spectroscopy Allows the Early Assessment of Drug Potency. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, vol. 59, pp. 6535-6539, ISSN:1433-7851
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Nguyen, Giang T H; Nocentini, Alessio; Angeli, Andrea; Gratteri, Paola; Supuran, Claudiu T; Donald, William A (2020). Perfluoroalkyl Substances of Significant Environmental Concern Can Strongly Inhibit Human Carbonic Anhydrase Isozymes. ANALYTICAL CHEMISTRY, vol. 92, pp. 4614-4622, ISSN:0003-2700
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Nocentini A.; Alterio V.; Bua S.; Micheli L.; Esposito D.; Buonanno M.; Bartolucci G.; Osman S.M.; Alothman Z.A.; Cirilli R.; Pierini M.; Monti S.M.; Di Cesare Mannelli L.; Gratteri P.; Ghelardini C.; De Simone G.; Supuran C.T. (2020). Phenyl(thio)phosphon(amid)ate Benzenesulfonamides as Potent and Selective Inhibitors of Human Carbonic Anhydrases II and VII Counteract Allodynia in a Mouse Model of Oxaliplatin-Induced Neuropathy. JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, pp. 5185-5200, ISSN:0022-2623
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Luchinat, Enrico; Barbieri, Letizia; Cremonini, Matteo; Nocentini, Alessio; Supuran, Claudiu T; Banci, Lucia (2020). Intracellular Binding/Unbinding Kinetics of Approved Drugs to Carbonic Anhydrase II Observed by in-Cell NMR. ACS CHEMICAL BIOLOGY, vol. 15, pp. 2792-2800, ISSN:1554-8929
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Said M.A.; Eldehna W.M.; Nocentini A.; Bonardi A.; Fahim S.H.; Bua S.; Soliman D.H.; Abdel-Aziz H.A.; Gratteri P.; Abou-Seri S.M.; Supuran C.T. (2020). Synthesis, biological and molecular dynamics investigations with a series of triazolopyrimidine/triazole-based benzenesulfonamides as novel carbonic anhydrase inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 185, pp. 1-13, ISSN:0223-5234
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Pustenko A.; Nocentini A.; Gratteri P.; Bonardi A.; Vozny I.; Zalubovskis R.; Supuran C.T. (2020). The antibiotic furagin and its derivatives are isoform-selective human carbonic anhydrase inhibitors. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 1011-1020, ISSN:1475-6366
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Said M.A.; Eldehna W.M.; Nocentini A.; Fahim S.H.; Bonardi A.; Elgazar A.A.; Krystof V.; Soliman D.H.; Abdel-Aziz H.A.; Gratteri P.; Abou-Seri S.M.; Supuran C.T. (2020). Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 189, pp. 1-14, ISSN:0223-5234
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Hargunani P.; Tadge N.; Ceruso M.; Leitans J.; Kazaks A.; Tars K.; Gratteri P.; Supuran C.T.; Nocentini A.; Toraskar M.P. (2020). Aryl-4,5-dihydro-1H-pyrazole-1-carboxamide derivatives bearing a sulfonamide moiety show single-digit nanomolar-to-subnanomolar inhibition constants against the tumor-associated human carbonic anhydrases IX and XII. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, pp. 1-11, ISSN:1661-6596
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Ceni C.; Catarzi D.; Varano F.; Ben D.D.; Marucci G.; Buccioni M.; Volpini R.; Angeli A.; Nocentini A.; Gratteri P.; Supuran C.T.; Colotta V. (2020). Discovery of first-in-class multi-target adenosine A2A receptor antagonists-carbonic anhydrase IX and XII inhibitors. 8-Amino-6-aryl-2-phenyl-1,2,4-triazolo [4,3-a]pyrazin-3-one derivatives as new potential antitumor agents. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 201, pp. 0-16, ISSN:0223-5234
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Pustenko A.; Nocentini A.; Balasova A.; Alafeefy A.; Krasavin M.; Zalubovskis R.; Supuran C.T. (2020). Aryl derivatives of 3H-1,2-benzoxathiepine 2,2-dioxide as carbonic anhydrase inhibitors. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 245-254, ISSN:1475-6366
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Uslu A.G.; Gur Maz T.; Nocentini A.; Banoglu E.; Supuran C.T.; Caliskan B. (2020). Benzimidazole derivatives as potent and isoform selective tumor-associated carbonic anhydrase IX/XII inhibitors. BIOORGANIC CHEMISTRY, vol. 95, pp. 103544-103544, ISSN:0045-2068
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Scheila Daiane Schmidt, Alessia Costa, Barbara Rani, Eduarda Godfried Nachtigall, Maria Beatrice Passani, Fabrizio Carta, Alessio Nocentini, Jociane de Carvalho Myskiw, Cristiane Regina Guerino Furini, Claudiu T. Supuran, Ivan Izquierdo, Patrizio Blandina, Gustavo Provensi (2020). The role of carbonic anhydrases in extinction of contextual fear memory. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, pp. 1-9, ISSN:0027-8424
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Fares, Mohamed; Eldehna, Wagdy M; Bua, Silvia; Lanzi, Cecilia; Lucarini, Laura; Masini, Emanuela; Peat, Thomas S; Abdel-Aziz, Hatem A; Nocentini, Alessio; Keller, Paul A; Supuran, Claudiu T (2020). Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action. JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, pp. 3317-3326, ISSN:1520-4804
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Nocentini A.; Del Prete S.; Mastrolorenzo M.D.; Donald W.A.; Capasso C.; Supuran C.T. (2020). Activation studies of the β-carbonic anhydrases from Escherichia coli with amino acids and amines. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 1379-1386, ISSN:1475-6366
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El-Azab A.S.; Abdel-Aziz A.A.-M.; Ahmed H.E.A.; Bua S.; Nocentini A.; AlSaif N.A.; Obaidullah A.J.; Hefnawy M.M.; Supuran C.T. (2020). Exploring structure-activity relationship of S-substituted 2-mercaptoquinazolin-4(3H)-one including 4-ethylbenzenesulfonamides as human carbonic anhydrase inhibitors. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 598-609, ISSN:1475-6366
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Pustenko A.; Nocentini A.; Balasova A.; Krasavin M.; Zalubovskis R.; Supuran C.T. (2020). 7-Acylamino-3H-1,2-benzoxathiepine 2,2-dioxides as new isoform-selective carbonic anhydrase IX and XII inhibitors. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 35, pp. 650-656, ISSN:1475-6366
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Nocentini A.; Tanc M. (2019). CO2-capture by engineered mammalian carbonic anhydrases. In: Alessio Nocentini, Claudiu T. Supuran. Carbonic Anhydrases: Biochemistry and Pharmacology of an Evergreen Pharmaceutical Target, pp. 515-530 Elsevier, ISBN:9780128164761.
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Nocentini A.; Supuran C.T. (2019). Carbonic anhydrase inhibitors for the treatment of neuropathic pain and arthritis. In: Alessio Nocentini, Claudiu T. Supuran. Carbonic Anhydrases: Biochemistry and Pharmacology of an Evergreen Pharmaceutical Target, pp. 367-386 Elsevier, ISBN:9780128164761.
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Nocentini A.; Donald W.A.; Supuran C.T. (2019). Human carbonic anhydrases: Tissue distribution, physiological role, and druggability. In: Alessio Nocentini, Claudiu T. Supuran. Carbonic Anhydrases: Biochemistry and Pharmacology of an Evergreen Pharmaceutical Target, pp. 151-185 Elsevier, ISBN:9780128164761.
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Bua S.; Nocentini A.; Supuran C.T. (2019). Carbonic anhydrase inhibitors as diuretics. In: Alessio Nocentini, Claudiu T. Supuran. Carbonic Anhydrases: Biochemistry and Pharmacology of an Evergreen Pharmaceutical Target, pp. 287-309 Elsevier, ISBN:9780128164761.
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Nocentini A.; Supuran C.T. (2019). Preface. In: Alessio Nocentini, Claudiu T. Supuran. Carbonic Anhydrases: Biochemistry and Pharmacology of an Evergreen Pharmaceutical Target, pp. xvii-xix Elsevier, ISBN:9780128164761.
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Nocentini A.; Supuran C.T. (2019). Carbonic anhydrases: An overview. In: Alessio Nocentini, Claudiu T.Supuran. Carbonic Anhydrases: Biochemistry and Pharmacology of an Evergreen Pharmaceutical Target, pp. 3-16 Elsevier, ISBN:9780128164761.
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El-Azab A.S.; Abdel-Aziz A.A.-M.; Bua S.; Nocentini A.; Alanazi M.M.; AlSaif N.A.; Al-Suwaidan I.A.; Hefnawy M.M.; Supuran C.T. (2019). Synthesis and comparative carbonic anhydrase inhibition of new Schiff's bases incorporating benzenesulfonamide, methanesulfonamide, and methylsulfonylbenzene scaffolds. BIOORGANIC CHEMISTRY, vol. 92, pp. 103225-103225, ISSN:0045-2068
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Eldehna W.M.; Abdelrahman M.A.; Nocentini A.; Bua S.; Al-Rashood S.T.; Hassan G.S.; Bonardi A.; Almehizia A.A.; Alkahtani H.M.; Alharbi A.; Gratteri P.; Supuran C.T. (2019). Synthesis, biological evaluation and in silico studies with 4-benzylidene-2-phenyl-5(4H)-imidazolone-based benzenesulfonamides as novel selective carbonic anhydrase IX inhibitors endowed with anticancer activity. BIOORGANIC CHEMISTRY, vol. 90, pp. 103102-103111, ISSN:0045-2068
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Nocentini A.; Supuran C.T. (2019). Advances in the structural annotation of human carbonic anhydrases and impact on future drug discovery. EXPERT OPINION ON DRUG DISCOVERY, vol. 14, pp. 1175-1197, ISSN:1746-0441
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Nocentini A.; Osman S.M.; Del Prete S.; Capasso C.; ALOthman Z.A.; Supuran C.T. (2019). Extending the γ-class carbonic anhydrases inhibition profiles with phenolic compounds. BIOORGANIC CHEMISTRY, vol. 93, pp. 103336-103336, ISSN:0045-2068
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Nocentini A.; Osman S.M.; Almeida I.A.; Cardoso V.; Alasmary F.A.S.; AlOthman Z.; Vermelho A.B.; Gratteri P.; Supuran C.T. (2019). Appraisal of anti-protozoan activity of nitroaromatic benzenesulfonamides inhibiting carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 34 (1), pp. 1164-1171, ISSN:1475-6366, TAYLOR & FRANCIS LTD:
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Pasha A.; Vignoli M.; Subbiani A.; Nocentini A.; Selleri S.; Gratteri P.; Dabraio A.; Casini T.; Filippi L.; Fotzi I.; Favre C.; Calvani M. (2019). β3-adrenoreceptor activity limits apigenin efficacy in ewing sarcoma cells: A dual approach to prevent cell survival. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 20, pp. 2149-2162, ISSN:1661-6596
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Milite C.; Amendola G.; Nocentini A.; Bua S.; Cipriano A.; Barresi E.; Feoli A.; Novellino E.; Da Settimo F.; Supuran C.T.; Castellano S.; Cosconati S.; Taliani S. (2019). Novel 2-substituted-benzimidazole-6-sulfonamides as carbonic anhydrase inhibitors: synthesis, biological evaluation against isoforms I, II, IX and XII and molecular docking studies. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 34, pp. 1697-1710, ISSN:1475-6366
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Kalinin S.; Valtari A.; Ruponen M.; Toropainen E.; Kovalenko A.; Nocentini A.; Gureev M.; Dar'in D.; Urtti A.; Supuran C.T.; Krasavin M. (2019). Highly hydrophilic 1,3-oxazol-5-yl benzenesulfonamide inhibitors of carbonic anhydrase II for reduction of glaucoma-related intraocular pressure. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 27, pp. 115086--, ISSN:0968-0896
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El-Azab A.S.; Abdel-Aziz A.A.-M.; Bua S.; Nocentini A.; AlSaif N.A.; Almehizia A.A.; Alanazi M.M.; Hefnawy M.M.; Supuran C.T. (2019). New anthranilic acid-incorporating N-benzenesulfonamidophthalimides as potent inhibitors of carbonic anhydrases I, II, IX, and XII: Synthesis, in vitro testing, and in silico assessment. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 181, pp. 111573--, ISSN:0223-5234
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Abdelrahman M.A.; Eldehna W.M.; Nocentini A.; Bua S.; Al-Rashood S.T.; Hassan G.S.; Bonardi A.; Almehizia A.A.; Alkahtani H.M.; Alharbi A.; Gratteri P.; Supuran C.T. (2019). Novel diamide-based benzenesulfonamides as selective carbonic anhydrase ix inhibitors endowed with antitumor activity: Synthesis, biological evaluation and in silico insights. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 20, pp. 2484-2499, ISSN:1661-6596
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Akocak S.; Lolak N.; Bua S.; Nocentini A.; Supuran C.T. (2019). Activation of human α-carbonic anhydrase isoforms I, II, IV and VII with bis-histamine schiff bases and bis-spinaceamine substituted derivatives. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 34, pp. 1193-1198, ISSN:1475-6366
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Nocentini A.; Supuran C.T. (2019). Adrenergic agonists and antagonists as antiglaucoma agents: a literature and patent review (2013–2019). EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 29, pp. 805-815, ISSN:1354-3776
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Angeli A.; Ferraroni M.; Nocentini A.; Selleri S.; Gratteri P.; Supuran C.T.; Carta F. (2019). Polypharmacology of epacadostat: A potent and selective inhibitor of the tumor associated carbonic anhydrases IX and XII. CHEMICAL COMMUNICATIONS, vol. 55, pp. 5720-5723, ISSN:1359-7345
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Gustavo Provensi, Fabrizio Carta, Alessio Nocentini, Claudiu T. Supuran, Fiorella Casamenti, Maria Beatrice Passani, Silvia Fossati (2019). A New Kid on the Block? Carbonic Anhydrases as Possible New Targets in Alzheimer's Disease. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 20, pp. 4724-4741, ISSN:1422-0067
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Moi D.; Nocentini A.; Deplano A.; Balboni G.; Supuran C.T.; Onnis V. (2019). Structure-activity relationship with pyrazoline-based aromatic sulfamates as carbonic anhydrase isoforms I, II, IX and XII inhibitors: Synthesis and biological evaluation. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 182, pp. 111638-111649, ISSN:1768-3254
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Alessandro Bonardi, Paola Gratteri, Alessio Nocentini (2019). Chpater 19 Carbonic Anhydrases from Pathogens: Fungal Carbonic Anhydrases And Their Inhibitors as Potential Antifungal Agents.. In: C.T. Supuran, A. Nocentini. Carbonic Anhydrases, pp. 419-448 Elsevier, ISBN:978-0-12-816476-1.
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Nocentini, Alessio; Lucidi, Alessia; Perut, Francesca; Massa, Annamaria; Tomaselli, Daniela; Gratteri, Paola; Baldini, Nicola; Rotili, Dante; Mai, Antonello; Supuran, Claudiu T.* (2019). α,γ-Diketocarboxylic Acids and Their Esters Act as Carbonic Anhydrase IX and XII Selective Inhibitors. ACS MEDICINAL CHEMISTRY LETTERS, vol. 10, pp. 661-665, ISSN:1948-5875
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Abdel-Aziz, Alaa A.-M.; El-Azab, Adel S.; Ghiaty, Adel H.; Gratteri, Paola; Supuran, Claudiu T.; Nocentini, Alessio (2019). 4-Substituted benzenesulfonamides featuring cyclic imides moieties exhibit potent and isoform-selective carbonic anhydrase II/IX inhibition. BIOORGANIC CHEMISTRY, vol. 83, pp. 198-204, ISSN:0045-2068, Academic Press Inc.: 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
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Angeli, Andrea; Tanini, Damiano; Nocentini, Alessio; Capperucci, Antonella; Ferraroni, Marta; Gratteri, Paola; Supuran, Claudiu T.* (2019). Selenols: a new class of carbonic anhydrase inhibitors. CHEMICAL COMMUNICATIONS, vol. 55, pp. 648-651, ISSN:1359-7345
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Nocentini, Alessio; Gratteri, Paola*; Supuran, Claudiu T. (2019). Phosphorus versus Sulfur: Discovery of Benzenephosphonamidates as Versatile Sulfonamide-Mimic Chemotypes Acting as Carbonic Anhydrase Inhibitors. CHEMISTRY-A EUROPEAN JOURNAL, vol. 25, pp. 1188-1192, ISSN:0947-6539
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Bonardi, Alessandro; Vermelho, Alane Beatriz; Da Silva Cardoso, Veronica; De Souza Pereira, Mirian Claudia; Da Silva Lara, Leonardo; Selleri, Silvia; Gratteri, Paola; Supuran, Claudiu T.; Nocentini, Alessio (2019). N-Nitrosulfonamides as Carbonic Anhydrase Inhibitors: A Promising Chemotype for Targeting Chagas Disease and Leishmaniasis. ACS MEDICINAL CHEMISTRY LETTERS, vol. 10, pp. 413-418, ISSN:1948-5875
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Eldehna, Wagdy M.*; Abo-Ashour, Mahmoud F.; Nocentini, Alessio; El-Haggar, Radwan S.; Bua, Silvia; Bonardi, Alessandro; Al-Rashood, Sara T.; Hassan, Ghada S.; Gratteri, Paola; Abdel-Aziz, Hatem A.; Supuran, Claudiu T. (2019). Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 162, pp. 147-160, ISSN:0223-5234
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Vats L.; Kumar R.; Bua S.; Nocentini A.; Gratteri P.; Supuran C.T.; Sharma P.K. (2019). Continued exploration and tail approach synthesis of benzenesulfonamides containing triazole and dual triazole moieties as carbonic anhydrase I, II, IV and IX inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 183, pp. 1-10, ISSN:0223-5234
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Abo-Ashour M.F.; Eldehna W.M.; Nocentini A.; Bonardi A.; Bua S.; Ibrahim H.S.; Elaasser M.M.; Krystof V.; Jorda R.; Gratteri P.; Abou-Seri S.M.; Supuran C.T. (2019). 3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and in silico insights. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 184, pp. 1-11, ISSN:0223-5234
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Supuran C.T.; Nocentini A. (2019). Carbonic anhydrases: Biochemistry and pharmacology of an evergreen pharmaceutical target. Elsevier, ISBN:9780128164761
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Larcher A.; Nocentini A.; Supuran C.T.; Winum J.-Y.; Van Der Lee A.; Vasseur J.-J.; Laurencin D.; Smietana M. (2019). Bis-benzoxaboroles: design, synthesis, and biological evaluation as carbonic anhydrase inhibitors. ACS MEDICINAL CHEMISTRY LETTERS, vol. 10, pp. 1205-1210, ISSN:1948-5875
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Allam H.A.; Fahim S.H.; F.Abo-Ashour M.; Nocentini A.; Elbakry M.E.; Abdelrahman M.A.; Eldehna W.M.; Ibrahim H.S.; Supuran C.T. (2019). Application of hydrazino and hydrazido linkers to connect benzenesulfonamides with hydrophilic/phobic tails for targeting the middle region of human carbonic anhydrases active site: Selective inhibitors of hCA IX. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 179, pp. 547-556, ISSN:1768-3254
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Akocak, Suleyman; Lolak, Nabih; Bua, Silvia; Nocentini, Alessio; Karakoc, Gulcin; Supuran, Claudiu T (2019). α-Carbonic anhydrases are strongly activated by spinaceamine derivatives. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 27, pp. 800-804, ISSN:1464-3391
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Berrino E.; Milazzo L.; Micheli L.; Vullo D.; Angeli A.; Bozdag M.; Nocentini A.; Menicatti M.; Bartolucci G.; Di Cesare Mannelli L.; Ghelardini C.; Supuran C.T.; Carta F. (2019). Synthesis and evaluation of carbonic anhydrase inhibitors with carbon monoxide releasing properties for the management of rheumatoid arthritis. JOURNAL OF MEDICINAL CHEMISTRY, vol. 62, pp. 7233-7249, ISSN:1520-4804
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Kalinin, Stanislav; Nocentini, Alessio; Kovalenko, Alexander; Sharoyko, Vladimir; Bonardi, Alessandro; Angeli, Andrea; Gratteri, Paola; Tennikova, Tatiana B.; Supuran, Claudiu T.; Krasavin, Mikhail (2019). From random to rational: A discovery approach to selective subnanomolar inhibitors of human carbonic anhydrase IV based on the Castagnoli-Cushman multicomponent reaction. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 182, pp. 111642-111660, ISSN:1768-3254
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El-Azab, Adel S; Abdel-Aziz, Alaa A-M; Bua, Sivia; Nocentini, Alessio; El-Gendy, Manal A; Mohamed, Menshawy A; Shawer, Taghreed Z; AlSaif, Nawaf A; Supuran, Claudiu T (2019). Synthesis of benzensulfonamides linked to quinazoline scaffolds as novel carbonic anhydrase inhibitors. BIOORGANIC CHEMISTRY, vol. 87, pp. 78-90, ISSN:0045-2068
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Krasavin, Mikhail; Shetnev, Anton; Baykov, Sergey; Kalinin, Stanislav; Nocentini, Alessio; Sharoyko, Vladimir; Poli, Giulio; Tuccinardi, Tiziano; Korsakov, Mikhail; Tennikova, Tatiana B; Supuran, Claudiu T (2019). Pyridazinone-substituted benzenesulfonamides display potent inhibition of membrane-bound human carbonic anhydrase IX and promising antiproliferative activity against cancer cell lines. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 168, pp. 301-314, ISSN:1768-3254
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Bua, Silvia; Osman, Sameh M; Del Prete, Sonia; Capasso, Clemente; AlOthman, Zeid; Nocentini, Alessio; Supuran, Claudiu T (2019). Click-tailed benzenesulfonamides as potent bacterial carbonic anhydrase inhibitors for targeting Mycobacterium tuberculosis and Vibrio cholerae. BIOORGANIC CHEMISTRY, vol. 86, pp. 183-186, ISSN:0045-2068
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Rogato, Alessandra; Del Prete, Sonia; Nocentini, Alessio; Carginale, Vincenzo; Supuran, Claudiu T; Capasso, Clemente (2019). Phaeodactylum tricornutum as a model organism for testing the membrane penetrability of sulphonamide carbonic anhydrase inhibitors. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 34, pp. 510-518, ISSN:1475-6374
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Abo-Ashour, Mahmoud F; Eldehna, Wagdy M; Nocentini, Alessio; Ibrahim, Hany S; Bua, Silvia; Abdel-Aziz, Hatem A; Abou-Seri, Sahar M; Supuran, Claudiu T (2019). Novel synthesized SLC-0111 thiazole and thiadiazole analogues: Determination of their carbonic anhydrase inhibitory activity and molecular modeling studies. BIOORGANIC CHEMISTRY, vol. 87, pp. 794-802, ISSN:0045-2068
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Krasavin, Mikhail; Shetnev, Anton; Sharonova, Tatyana; Baykov, Sergey; Kalinin, Stanislav; Nocentini, Alessio; Sharoyko, Vladimir; Poli, Giulio; Tuccinardi, Tiziano; Presnukhina, Sofia; Tennikova, Tatiana B; Supuran, Claudiu T (2019). Continued exploration of 1,2,4-oxadiazole periphery for carbonic anhydrase-targeting primary arene sulfonamides: Discovery of subnanomolar inhibitors of membrane-bound hCA IX isoform that selectively kill cancer cells in hypoxic environment. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 164, pp. 92-105, ISSN:1768-3254
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Aimene, Yassine; Eychenne, Romain; Mallet-Ladeira, Sonia; Saffon, Nathalie; Winum, Jean-Yves; Nocentini, Alessio; Supuran, Claudiu T; Benoist, Eric; Seridi, Achour (2019). Novel Re(I) tricarbonyl coordination compounds based on 2-pyridyl-1,2,3-triazole derivatives bearing a 4-amino-substituted benzenesulfonamide arm: synthesis, crystal structure, computational studies and inhibitory activity against carbonic anhydrase I, II, and IX isoforms†. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 34, pp. 773-782, ISSN:1475-6374
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Abdel-Aziz, Alaa A-M; El-Azab, Adel S; Bua, Silvia; Nocentini, Alessio; Abu El-Enin, Mohamed A; Alanazi, Mohammed M; AlSaif, Nawaf A; Hefnawy, Mohamed M; Supuran, Claudiu T (2019). Design, synthesis, and carbonic anhydrase inhibition activity of benzenesulfonamide-linked novel pyrazoline derivatives. BIOORGANIC CHEMISTRY, vol. 87, pp. 425-431, ISSN:0045-2068
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Bua, Silvia; Osman, Sameh M; AlOthman, Zeid; Supuran, Claudiu T; Nocentini, Alessio (2019). Benzenesulfonamides incorporating nitrogenous bases show effective inhibition of β-carbonic anhydrases from the pathogenic fungi Cryptococcus neoformans, Candida glabrata and Malassezia globosa. BIOORGANIC CHEMISTRY, vol. 86, pp. 39-43, ISSN:0045-2068
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Kartsev V.; Geronikaki A.; Bua S.; Nocentini A.; Petrou A.; Lichitsky B.; Frasinyuk M.; Leitans J.; Kazaks A.; Tars K.; Supuran C.T. (2019). Extending the inhibition profiles of coumarin-based compounds against human carbonic anhydrases: Synthesis, biological, and in silico evaluation. MOLECULES, vol. 24, pp. 3580--, ISSN:1420-3049
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Kurt B.Z.; Dag A.; Dogan B.; Durdagi S.; Angeli A.; Nocentini A.; Supuran C.T.; Sonmez F. (2019). Synthesis, biological activity and multiscale molecular modeling studies of bis-coumarins as selective carbonic anhydrase IX and XII inhibitors with effective cytotoxicity against hepatocellular carcinoma. BIOORGANIC CHEMISTRY, vol. 87, pp. 838-850, ISSN:0045-2068
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Bibi D.; Shusterman B.; Nocentini A.; Supuran C.T.; Bialer M. (2019). Stereoselective pharmacokinetic and pharmacodynamic analysis of a CNS-active sulphamoylphenyl carbamate derivative. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 34, pp. 1078-1082, ISSN:1475-6366
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Eldehna, Wagdy M; Nocentini, Alessio; Al-Rashood, Sara T; Hassan, Ghada S; Alkahtani, Hamad M; Almehizia, Abdulrahman A; Reda, Ahmed M; Abdel-Aziz, Hatem A; Supuran, Claudiu T (2018). Tumor-associated carbonic anhydrase isoform IX and XII inhibitory properties of certain isatin-bearing sulfonamides endowed with in vitro antitumor activity towards colon cancer. BIOORGANIC CHEMISTRY, vol. 81, pp. 425-432, ISSN:0045-2068
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Ibrahim, Hany S.*; Allam, Heba Abdelrasheed; Mahmoud, Walaa R.; Bonardi, Alessandro; Nocentini, Alessio; Gratteri, Paola; Ibrahim, Eslam S.; Abdel-Aziz, Hatem A.; Supuran, Claudiu T. (2018). Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective inhibitors for the tumor-associated hCA IX isoform. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 152, pp. 1-9, ISSN:0223-5234
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Nocentini, Alessio; Supuran, Claudiu T; Winum, Jean-Yves (2018). Benzoxaborole compounds for therapeutic uses: a patent review (2010- 2018). EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 28, pp. 493-504, ISSN:1354-3776
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Nocentini, Alessio; Bua, Silvia; Del Prete, Sonia; Heravi, Yeganeh Entezari; Saboury, Ali A; Karioti, Anastasia; Bilia, Anna Rita; Capasso, Clemente; Gratteri, Paola; Supuran, Claudiu T (2018). Natural Polyphenols Selectively Inhibit β-Carbonic Anhydrase from the Dandruff-Producing Fungus Malassezia globosa: Activity and Modeling Studies. CHEMMEDCHEM, vol. 13, pp. 816-823, ISSN:1860-7179
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Awadallah, Fadi M.; Bua, Silvia; Mahmoud, Walaa R.; Nada, Hossam H.; Nocentini, Alessio; Supuran, Claudiu T.* (2018). Inhibition studies on a panel of human carbonic anhydrases with N1-substituted secondary sulfonamides incorporating thiazolinone or imidazolone-indole tails. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 33, pp. 629-638, ISSN:1475-6366
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Niccolò Chiaramonte, Silvia Bua, Marta Ferraroni, Alessio Nocentini, Alessandro Bonardi, Gian Luca Bartolucci, Maria Concetta Durante, Laura Lucarini, Donata Chiapponi, Silvia Dei, Dina Manetti, Elisabetta Teodori, Paola Gratteri, Emanuela Masini, Claudiu T. Supuran, Maria Novella Romanelli (2018). 2-Benzylpiperazine: a new scaffold for potent human Carbonic Anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 151, pp. 363-375, ISSN:1768-3254
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Nocentini A, Trallori E, Singh S, Lomelino CL, Bartolucci G, Di Cesare Mannelli L, Ghelardini C, McKenna R, Gratteri P, Supuran CT (2018). 4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII showing hypoxia-enhanced anti-proliferative profiles.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 61, pp. 10860-10874, ISSN:0022-2623
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Nakai, Misaki; Pan, Jihne; Lin, Kuo-Shyan; Thompson, John R; Nocentini, Alessio; Supuran, Claudiu T; Nakabayashi, Yasuo; Storr, Tim (2018). Evaluation of 99mTc-sulfonamide and sulfocoumarin derivatives for imaging carbonic anhydrase IX expression. JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 185, pp. 63-70, ISSN:1873-3344
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Nocentini, Alessio; Carta, Fabrizio; Tanc, Muhammet; Selleri, Silvia; Supuran, Claudiu T.; Bazzicalupi, Carla*; Gratteri, Paola (2018). Deciphering the Mechanism of Human Carbonic Anhydrases Inhibition with Sulfocoumarins: Computational and Experimental Studies. CHEMISTRY-A EUROPEAN JOURNAL, vol. 24, pp. 7840-7844, ISSN:0947-6539
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Nocentini, Alessio; Bonardi, Alessandro; Gratteri, Paola; Cerra, Bruno; Gioiello, Antimo*; Supuran, Claudiu T. (2018). Steroids interfere with human carbonic anhydrase activity by using alternative binding mechanisms. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 33, pp. 1453-1459, ISSN:1475-6366
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Mahmood, Shams-ul; Saeed, Aamer*; Bua, Sivia; Nocentini, Alessio; Gratteri, Paola; Supuran, Claudiu T. (2018). Synthesis, biological evaluation and computational studies of novel iminothiazolidinone benzenesulfonamides as potent carbonic anhydrase II and IX inhibitors. BIOORGANIC CHEMISTRY, vol. 77, pp. 381-386, ISSN:0045-2068
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Nocentini, Alessio; Ceruso, Mariangela; Bua, Silvia; Lomelino, Carrie L.; Andring, Jacob T.; McKenna, Robert; Lanzi, Cecilia; Sgambellone, Silvia; Pecori, Riccardo; Matucci, Rosanna; Filippi, Luca; Gratteri, Paola; Carta, Fabrizio; Masini, Emanuela; Selleri, Silvia*; Supuran, Claudiu T. (2018). Discovery of β-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy. JOURNAL OF MEDICINAL CHEMISTRY, vol. 61, pp. 5380-5394, ISSN:0022-2623
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Abdel-Aziz, Alaa A-M; El-Azab, Adel S; Abu El-Enin, Mohamed A; Almehizia, Abdulrahman A; Supuran, Claudiu T; Nocentini, Alessio (2018). Synthesis of novel isoindoline-1,3-dione-based oximes and benzenesulfonamide hydrazones as selective inhibitors of the tumor-associated carbonic anhydrase IX. BIOORGANIC CHEMISTRY, vol. 80, pp. 706-713, ISSN:0045-2068
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El-Gazzar, Marwa G; Nafie, Nessma H; Nocentini, Alessio; Ghorab, Mostafa M; Heiba, Helmi I; Supuran, Claudiu T (2018). Carbonic anhydrase inhibition with a series of novel benzenesulfonamide-triazole conjugates. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 33, pp. 1565-1574, ISSN:1475-6374
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Diuzheva, Alina; Carradori, Simone; Andruch, Vasil; Locatelli, Marcello; Luca, Elisa De; Tiecco, Matteo; Germani, Raimondo; Menghini, Luigi; Nocentini, Alessio; Gratteri, Paola; Campestre, Cristina (2018). Use of Innovative (Micro)Extraction Techniques to Characterise Harpagophytum procumbens Root and its Commercial Food Supplements. PHYTOCHEMICAL ANALYSIS, vol. 29, pp. 233-241, ISSN:0958-0344
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Mahmoud F. Abo-Ashour; Wagdy M. Eldehna; Alessio Nocentini; Hany S. Ibrahim; Silvia Bua; Sahar M. Abou-Seri; Claudiu T. Supuran (2018). Novel hydrazido benzenesulfonamides-isatin conjugates: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 157, pp. 28-36, ISSN:0223-5234
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Nocentini, Alessio; Supuran, Claudiu T (2018). Carbonic anhydrase inhibitors as antitumor/antimetastatic agents: a patent review (2008-2018). EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 28, pp. 729-740, ISSN:1354-3776
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Nocentini, Alessio; Moi, Davide; Balboni, Gianfranco; Salvadori, Severo; Onnis, Valentina; Supuran, Claudiu T (2018). Synthesis and biological evaluation of novel pyrazoline-based aromatic sulfamates with potent carbonic anhydrase isoforms II, IV and IX inhibitory efficacy. BIOORGANIC CHEMISTRY, vol. 77, pp. 633-639, ISSN:0045-2068
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Nocentini, Alessio; Cadoni, Roberta; Dumy, Pascal; Supuran, Claudiu T; Winum, Jean-Yves (2018). Carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani chagasi are inhibited by benzoxaboroles. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 33, pp. 286-289, ISSN:1475-6366
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Alessio Nocentini (2018). MODELING AND STRUCTURE-BASED APPROACHES IN THE DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF LIGANDS TARGETING THE METALLOENZYMES CARBONIC ANHYDRASES. (Tutor: Paola Gratteri e Claudiu T. Supuran)
Nocentini, Alessio; Moi, Davide; Balboni, Gianfranco; Onnis, Valentina; Supuran, Claudiu T (2018). Discovery of thiazolin-4-one-based aromatic sulfamates as a new class of carbonic anhydrase isoforms I, II, IV, and IX inhibitors. BIOORGANIC CHEMISTRY, vol. 77, pp. 293-299, ISSN:0045-2068
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Vullo, Daniela; Del Prete, Sonia; Nocentini, Alessio; Osman, Sameh M.; Alothman, Zeid; Capasso, Clemente; Bozdag, Murat; Carta, Fabrizio; Gratteri, Paola; Supuran, Claudiu T. (2017). Dithiocarbamates effectively inhibit the β-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 25, pp. 1260-1265, ISSN:0968-0896
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Fares, Mohamed; Eladwy, Radwa A.; Nocentini, Alessio; El Hadi, Soha R. Abd; Ghabbour, Hazem A.; Abdel-Megeed, Ashraf; Eldehna, Wagdy M.; Abdel-Aziz, Hatem A.; Supuran, Claudiu T. (2017). Synthesis of bulky-tailed sulfonamides incorporating pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-1(5H)-yl) moieties and evaluation of their carbonic anhydrases I, II, IV and IX inhibitory effects. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 25, pp. 2210-2217, ISSN:0968-0896
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Akocak S.; Lolak N.; Nocentini A.; Karakoc G.; Tufan A.; Supuran C.T. (2017). Synthesis and biological evaluation of novel aromatic and heterocyclic bis-sulfonamide Schiff bases as carbonic anhydrase I, II, VII and IX inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 25, pp. 3093-3097, ISSN:0968-0896
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Entezari Heravi, Yeganeh; Bua, Silvia; Nocentini, Alessio; Del Prete, Sonia; Saboury, Ali Akbar; Sereshti, Hassan; Capasso, Clemente; Gratteri, Paola; Supuran, Claudiu T (2017). Inhibition of Malassezia globosa carbonic anhydrase with phenols. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 25, pp. 2577-2582, ISSN:0968-0896
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Fragai, Marco; Comito, Giuseppina; Di Cesare Mannelli, Lorenzo; Gualdani, Roberta; Calderone, Vito; Louka, Alexandra; Richichi, Barbara; Francesconi, Oscar; Angeli, Andrea; Nocentini, Alessio; Gratteri, Paola; Chiarugi, Paola; Ghelardini, Carla; Tadini-Buoninsegni, Francesco; Supuran, Claudiu T; Nativi, Cristina (2017). Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX). JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, pp. 9003-9011, ISSN:1520-4804
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Eldehna, Wagdy M; Al-Ansary, Ghada H.; Bua, Silvia; Nocentini, Alessio; Gratteri, Paola; Altoukhy, Ayman; Ghabbour, Hazem; Ahmed, Hanaa Y.; Supuran, Claudiu T. (2017). Novel indolin-2-one-based sulfonamides as carbonic anhydrase inhibitors: Synthesis, in vitro biological evaluation against carbonic anhydrases isoforms I, II, IV and VII and molecular docking studies. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 127, pp. 521-530, ISSN:0223-5234
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Altug, Cevher; Güneş, Hanife; Nocentini, Alessio; Monti, Simona Maria; Buonanno, Martina; Supuran, Claudiu T. (2017). Synthesis of isoxazole-containing sulfonamides with potent carbonic anhydrase II and VII inhibitory properties. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 25, pp. 1456-1464, ISSN:0968-0896
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Nocentini, Alessio; Cadoni, Roberta; Del Prete, Sonia; Capasso, Clemente; Dumy, Pascal; Gratteri, Paola; Supuran, Claudiu T.; Winum, Jean-Yves (2017). Benzoxaboroles as Efficient Inhibitors of the β-Carbonic Anhydrases from Pathogenic Fungi: Activity and Modeling Study. ACS MEDICINAL CHEMISTRY LETTERS, vol. 8, pp. 1194-1198, ISSN:1948-5875
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Angeli, Andrea; Abdel-Aziz, Alaa A. -. M.; Nocentini, Alessio; El-Azab, Adel S.; Gratteri, Paola; Supuran, Claudiu T. (2017). Synthesis and carbonic anhydrase inhibition of polycyclic imides incorporating N-benzenesulfonamide moieties. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 25, pp. 5373-5379, ISSN:0968-0896
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Nocentini, Alessio; Bua, Silvia; Lomelino, Carrie L.; Mckenna, Robert; Menicatti, Marta; Bartolucci, Gianluca; Tenci, Barbara; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Gratteri, Paola; Supuran, Claudiu T. (2017). Discovery of New Sulfonamide Carbonic Anhydrase IX Inhibitors Incorporating Nitrogenous Bases. ACS MEDICINAL CHEMISTRY LETTERS, vol. 8, pp. 1314-1319, ISSN:1948-5875
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Eldehna, Wagdy M.; Abo-Ashour, Mahmoud F.; Nocentini, Alessio; Gratteri, Paola; Eissa, Ibrahim H.; Fares, Mohamed; Ismael, Omnia E.; Ghabbour, Hazem A.; Elaasser, Mahmoud M.; Abdel-Aziz, Hatem A.; Supuran, Claudiu T. (2017). Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 139, pp. 250-262, ISSN:0223-5234
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Nocentini, Alessio; Vullo, Daniela; Del Prete, Sonia; Osman, Sameh M.; Alasmary, Fatmah A. S.; Alothman, Zeid; Capasso, Clemente; Carta, Fabrizio; Gratteri, Paola; Supuran, Claudiu T. (2017). Inhibition of the β-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa with monothiocarbamates. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 32, pp. 1064-1070, ISSN:1475-6366
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Zhang, Zhengxing; Lau, Joseph; Zhang, Chengcheng; Colpo, Nadine; Nocentini, Alessio; Supuran, Claudiu T; Bénard, François; Lin, Kuo-Shyan (2017). Design, synthesis and evaluation of 18F-labeled cationic carbonic anhydrase IX inhibitors for PET imaging. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 32, pp. 722-730, ISSN:1475-6374
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Bibi, David; Mawasi, Hafiz; Nocentini, Alessio; Supuran, Claudiu T; Wlodarczyk, Bogdan; Finnell, Richard H; Bialer, Meir (2017). Design and Comparative Evaluation of the Anticonvulsant Profile, Carbonic-Anhydrate Inhibition and Teratogenicity of Novel Carbamate Derivatives of Branched Aliphatic Carboxylic Acids with 4-Aminobenzensulfonamide. NEUROCHEMICAL RESEARCH, vol. 42, pp. 1972-1982, ISSN:0364-3190
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Nocentini, Alessio; Ceruso, Mariangela; Carta, Fabrizio; Supuran, Claudiu T. (2016). 7-Aryl-triazolyl-substituted sulfocoumarins are potent, selective inhibitors of the tumor-associated carbonic anhydrase IX and XII. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 31, pp. 1226-1233, ISSN:1475-6366
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Angeli, A; Peat, T.S.; Bartolucci, G.; Nocentini, A.; Supuran, C.T.; Carta, F. (2016). Intramolecular oxidative deselenization of acylselenoureas: a facile synthesis of benzoxazole amides and carbonic anhydrase inhibitors. ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 14, pp. 11353-11356, ISSN:1477-0520
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Nocentini, Alessio; Vullo, Daniela; Bartolucci, Gianluca; Supuran, Claudiu T (2016). N-Nitrosulfonamides: A new chemotype for carbonic anhydrase inhibition. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 24, pp. 3612-3617, ISSN:0968-0896
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Nocentini, Alessio; Ferraroni, Marta; Carta, Fabrizio; Ceruso, Mariangela; Gratteri, Paola; Lanzi, Cecilia; Masini, Emanuela; Supuran, Claudiu T (2016). Benzenesulfonamides Incorporating Flexible Triazole Moieties Are Highly Effective Carbonic Anhydrase Inhibitors: Synthesis and Kinetic, Crystallographic, Computational, and Intraocular Pressure Lowering Investigations. JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, pp. 10692-10704, ISSN:0022-2623
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Ferraroni, Marta; Bazzicalupi, Carla; Papi, Francesco; Fiorillo, Gaetano; Guamán-Ortiz, Luis Miguel; Nocentini, Alessio; Scovassi, Anna Ivana; Lombardi, Paolo; Gratteri, Paola (2016). Solution and Solid-State Analysis of Binding of 13-Substituted Berberine Analogues to Human Telomeric G-quadruplexes. CHEMISTRY - AN ASIAN JOURNAL, vol. 11, pp. 1107-1115, ISSN:1861-4728
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Nocentini, Alessio; Carta, Fabrizio; Ceruso, Mariangela; Bartolucci, Gianluca; Supuran, Claudiu T. (2015). Click-tailed coumarins with potent and selective inhibitory action against the tumor-associated carbonic anhydrases IX and XII. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 23, pp. 6955-6966, ISSN:0968-0896
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