Personale

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Italiano

Biografia

Curriculum

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Pubblicazioni

Insegnamenti

English

Biography

Curriculum

Interest

Luca MASSACESI

Ruolo attuale:: Professore Ordinario
SSD:: MEDS-12/A - Neurologia
Afferenza organizzativa:: Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino (NEUROFARBA)

Recapiti

	0557947927
	luca.massacesi(AT)unifi.it

Ulteriori Recapiti

	Dipartimento di Neuroscienze, Farmaco e Salute Bambino, Università di Firenze, Viale Pieraccini, 6 - 50139 Firenze. Dipartimento di Neuroscienze, Azienda Ospedaliero Universitaria Careggi
	055 2751697 - 055 2751697
	massacesi(AT)unifi.it
	http://www.neurofarba.unifi.it/

Luca MASSACESI

Biografia

Profilo professionale e clinico

In qualità di Professore di Neurologia, il Prof. Massacesi svolge principalmente attività di ricerca e didattica. La sua attività di ricerca è focalizzata sulle malattie infiammatorie del sistema nervoso (come per esempio la sclerosi multipla) e sulla traslazione clinica dei risultati ottenuti. È specialista in Neurologia dal 1986 e in Immunologia Clinica dal 1990.

Come Direttore di uno dei reparti di Neurologia dell’AOU Careggi, è responsabile della diagnosi e del trattamento di tutte le patologie neurologiche dell’adulto. Coordina inoltre l’ambulatorio per migliaia di pazienti cronici affetti da malattie infiammatorie del sistema nervoso centrale e periferico, come sclerosi multipla (SM), vasculiti croniche del SNC, encefaliti, neuropatie infiammatorie periferiche, sindromi miasteniche.

In qualità di Coordinatore dell’Area Ricerca dell’AOU Careggi, supervisiona i programmi di supporto alla ricerca clinica dell’ospedale.

Traguardi professionali e scientifici

Modelli animali di sclerosi multipla: Negli anni ’80, durante il post-dottorato al Massachusetts General Hospital e alla Harvard University (Boston, USA), ha contribuito allo sviluppo e alla caratterizzazione immunologica del modello EAE (encefalomielite autoimmune sperimentale) nei primati non umani, oggi riferimento internazionale nel campo.
Rete europea sull’autoimmunità T-cellulare nella SM: Tornato in Italia, ha guidato il progetto europeo “European Concerted Action on T-cell autoimmunity in Multiple Sclerosis”, finanziato dalla Commissione Europea. Ha coordinato la riproduzione del modello di EAE in un centro di ricerca sui primati olandese e presso i National Institutes of Health (NIH, Bethesda, Md, USA), contribuendo a generare ipotesi pionieristiche che sono poi state ampiamente verificate sull’uomo (alcune delle quali con il suo contributo), rivelatesi fondamentali nella comprensione della patogenesi della SM:

Ruolo dei linfociti B e T nello sviluppo delle lesioni cerebrali
Segno della vena centrale (CVS) come marcatore specifico della SM alla risonanza magnetica
Compartimentalizzazione della risposta immunitaria nel SNC nelle lesioni croniche

Ruolo dei linfociti B nella SM: I suoi studi hanno contribuito alla comprensione del ruolo dei linfociti B nella patogenesi della SM, aprendo la strada all’efficacia della deplezione delle cellule B CD20+.
Segno della vena centrale (CVS): Durante l’anno sabbatico nel 2009 presso i NIH, ha collaborato con il Dr. Daniel Reich alla caratterizzazione del CVS, oggi segno MRi fondamentale per migliorare la specificità diagnostica della SM.
Compartimentalizzazione dell’infiammazione nel SNC: I dati ottenuti nei modelli EAE hanno contribuito a generare l’ipotesi che la progressione della disabilità nella SM sia dovuta alla compartimentalizzazione dell’infiammazione nel Sistema nervoso Centrale (SNC), contribuendo alla scoperta delle lesioni a bordo paramagnetico (PRL).
Contributo alla neuroimmunologia: La sua esperienza interdisciplinare ha contribuito allo sviluppo della neuroimmunologia come sotto-specialità innovativa della neurologia. Ha presieduto i gruppi di studio della Società Italiana di Neurologia (SIN) e della European Academy of Neurology (EAN).
Studi clinici: Negli ultimi vent’anni ha guidato numerosi studi clinici indipendenti, tra cui un RCT multicentrico finanziato da AIFA che ha dimostrato l’equivalenza terapeutica nella SM tra un farmaco orfano (azatioprina) ed un costoso farmaco ancora sotto brevetto (interferone beta).
Esperienza regolatoria sui farmaci: Per la sua competenza sui trial clinici e la sua reputazioen di indipendenza, è membro da 16 anni del Scientific Advisory Group – Neurology dell’EMA è stato per molti anni consulente per i farmaci neurologici dell’ Agenzia taliana del Farmaco (AIFA), contribuendo a valutare l’autorizzazione ed il rimborso di decine di farmaci per malattie o sintomi neurologici a livello europeo e nazionale.

Attività editoriale e pubblicazioni

Ha pubblicato circa 250 articoli scientifici su riviste internazionali peer-reviewed. Fa parte del comitato editoriale di due riviste scientifiche internazionali specializzate in neurologia.

Prospettive future

La carriera accademica e consulenziale del Prof. Massacesi è stata caratterizzata da una reputazione internazionale, indipendenza da interessi privati e da un forte impegno nella ricerca clinica indipendente, soprattutto nella sclerosi multipla. Le numerose consulenze e conferenze sponsorizzate a cui ha partecipato sono sempre state svolte nel rispetto delle normative italiane e delle linee guida dell’Università di Firenze e delle agenzie regolatorie.

Luca MASSACESI

Curriculum

Curriculum Vitae Europass

Personal Data
Name		Luca Massacesi
Address		Department of Neurosciences, Drug and Child Health - University of Florence; Dept. Neurology II, Careggi University Hospital. Largo Brambilla 3 - 50134, Florence, Italy
Phone		+39 0557947927
E-mail		massacesi@unifi.it
Nazionality		Italian
Date of Birth

Current Position
Name of the employer		University of Florence, Florence, Italy
Sector		Department of Neurosciences, Drug and Child Health
Position held		Full professor of Neurology

• Name of the employer		Careggi University Hospital - University of Florence
• sector		Department Neurology II
• Occupation or position held		Director

Main skills

Principal areas of expertise

Research clinical care and teaching in Neurology and particularly in Neuroimmunology with main interests in multiple sclerosis and related disorders, encephalitis, CNS vasculitis and in general in inflammatory diseases of the Nervous System.
Immunotherapies including autologous hematopoietic stem cell transplantation.
Imaging of the Central Nervous System.
Management and evaluation of clinical studies.
Drug evaluation and drug regulatory processes.
Clinical Management and Governance.
Ethic issues of clinical and preclinical research.

Work Experience (Academic)

• Dates (from – to)	1984 -1990
• Name of employer	Italian National Research Council and Clinica Malattie Nervose e Mentali, University of Florence
Sector	Neurology
Occupation or position held	Research fellow
Main activities and responsibilities	Research

Dates (from – to)	1988-1991
Name and address of employer	Massachusetts General Hospital - Harvard University, Boston, Ma, USA
Sector	Neuroimmunology Unit, Dept. of Neurology
Occupation or position held	Postdoctoral fellow.
Main activities and responsibilities	Research

Dates (from-to)	1995-2001
Name of employer	University of Florence – Florence, Italy
Sector	Department of Neurological e Psychiatric Sciences,
Occupation or position held	Assistant Professor (equivalent) of Neurology
Main activities and responsibilities	Research, teaching, clinical activity

Dates (from-to)	2001-2005
Name of the employer	University of Florence, Florence, Italy
Sector	Department of Neurological e Psychiatric Sciences
Occupation or position held	Associate Professor of Neurology
Main activities and responsibilities	Research, teaching, clinical activity

Dates (from-to)	2005- today
Name of the employer	University of Florence, Florence, Italy
Type of business or sector	Department of Neurological e Psychiatric Sciences-University of Florence (since 2013, Dept. of Neurosciences Drugs anch Child Health)
Occupation or position held	Full Professor of Neurology.
Main activities and responsibilities	Research, teaching, clinical activity

Dates (from-to)	2008-2012
Name of the employer	University of Florence
Type of business or sector
Occupation or position held	Director
Main activities and responsibilities	Research teaching, Research management.

Dates (from – to)	2008-2012
Name and address of employer	University of Florence
Type of business or sector	Resident Program in Neurophysiopathology
Occupation or position held	Director
Main activities and responsibilities	Teaching and tutorship of clinical activity

Dates (from – to)	2009-2010
Name of the employer	National Institute of Health, Bethesda, MD, USA
Type of business or sector	NINDS, Neuroimmunology Branch
Occupation or position held	Adjunct Scientist
Main activities and responsibilities	Research

Dates (from – to)	2010-2013
Name of the employer	National Institute of Health, Bethesda, MD, USA
Sector	NINDS, Neuroimmunology Branch
Occupation or position held	Special Investigator
Main activities and responsibilities	Research

Dates (from – to)	2016-2020
Name of the employer	University of Florence
Sector	Council of Discipline:
Occupation or position held	member
Main activities and responsibilities	Consulting the University of Florence Rector on discipline violations of Professors and Researchers.
Dates (from-to)	2018-today
Name of the employer	University of Florence-Careggi University Hospital
Sector	Conflict of interest evaluation committee (COVACI)
Occupation or position held	Delegate of the University of Florence Rector.
Main activities and responsibilities	Evaluation of potential conflict of interests of Staff Physicians and of University Professors and Researchers involved in clinical activities.
Dates (from-to)	2020- today
Name of the employer	University of Florence
Sector	Academic Senate member
Occupation or position held Main activities and responsibilities	Biomedical Area representative Control and collaboration to programming, regulating, and coordinating the activities of the Florence University Government.



Work Experience (Clinical)
Professional Registration	Ordine Medici of Florence, 07156
Dates (from – to) *Name of employer*	1983-1984 Italian Army-Florence Army Hospital
• Sector	Army Health Corp
• Occupation or position held Main activities and responsibilities	Lieutenant Staff Physician - Neurology Dept.
Dates (from – to)	1991-2008
Name of employer	Careggi University Hospital
Sector	Department of Neurology 1
Occupation or position held Main activities and responsibilities	Staff Neurologist clinical activity, clinical research, teaching,
Dates (from – to)	2008- today
Name of the employer	Careggi University Hospital
Sector Occupation or position held Main activities and responsibilities	Department Neurology 2: Director clinical activity, clinical management, clinical research, teaching,

Dates (from – to)	2012-2014
Name of the employer	Careggi University Hospital
Sector Occupation or position held	Department of Neurosciences Director
Main activities and responsibilities	clinical governance, clinical management

Education and academic background

• Date	1975-1982
Name and type of organization providing education and training	University of Florence
• Principal subjects/occupational skills covered	School of Medicine and Surgery
• Title of qualification awarded	Degree in Medicine and Surgery
• Level in national classification	110/110 cum laude

• Date	1982-1986
• Name and type of organization providing education and training	University of Florence
• Principal subjects/occupational skills covered	Resident Program in Neurology
• Title of qualification awarded	Board Certificate in Neurology
• Level in national classification	70/70 cum laude

• Date	1988-1990
Name and type of organization providing education and training	University of Florence
• Principal subjects/occupational skills covered	Resident Program in Clinical Immunology
• Title of qualification awarded	Board Certificate in Clinical Immunology
• Level in national classification	70/70 cum laude

Date	1982
• Name and type of organization providing training	Stanford University, Palo Alto. Ca, USA.,
sector	Neurology Department, Laboratory of Neurochemistry
Occupation or position held	visiting fellow.
Main activities and responsibilities	research

Date	1985
Name and type of organization providing training	National Institute of Health, Bethesda, MD, USA
sector	NINDS, Neuroimmunology Branch
Occupation or position held	visiting fellow
Main activities and responsibilities	research

Further scientific activities
1993-1994	- European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) executive committee: member
1993-2014	- Italian Multiple Sclerosis Society (AISM) Scientific Committee/Research and Evaluation Committee.; member
1994-1997	- R&D program of the del DG XII EU Commission Project Leader of the Concerted Action: "T-cell Autoimmunity in Multiple Sclerosis",
1997-1999	- Studio multicentrico italiano dell'Associazione Italiana Sclerosi Multipla (AISM): “Centralized Facility for genetic studies in Multiple Sclerosis". Coordinator
1997-2013	- Florence University-Magnetic Resonance Interdipartimental Center, steering committee: member
1999-2000	- International Federation of Multiple Sclerosis Societies: Scientific Program Committee; member of the Medical Advisory Board.
1995-2001	- Biomedical Primate Research EU Large Scale Facility, Rijswijk, Nederland; member of the Scientific Committee.
1998-2002	- Multicentric Italian Randomized Clinical Trial: “Open randomized clinical study on different doses of bIFN1a, also in association with Azathioprine, in patients with relapsing-remitting multiple sclerosis”: National coordinator
2006-2011		- Non-profit multicentric clinical RCT, sponsored by the Italian Medicine Agency (AIFA) “Randomized controlled study of Azathioprine versus Interferon beta in relapsing-remitting multiple sclerosis”. Scientific coordinator.
2010-2016		- Data and Safety monitoring board (DSMB) of the National Institutes of Health phase II intramural clinical study: Investigating the mechanism of action of DAC HYP (Daclizumab) in the treatment of highly inflammatory multiple sclerosis: Chairman.
2009-2016		- Agenzia Italiana del Farmaco (AIFA; Italian Meidicines Agency), Rome, Italy; Scientific Advisory Committee on Neurosciences: member.
2011-2018		- Non-profit multicentric clinical trial funded by the Emilia- Romagna regional Government: “Multicentric RCT for the evaluation of efficacy and safety of extracranial vein unblocking in the treatment for multiple sclerosis”. Member of the steering committee.
2009- 2025		- European Medicines Agency (EMA), Amsterdam, The Nederlands; Scientific Advisory Group – Neurology, core member.
2014-2023		- University of Florence - Magnetic Resonance Interdipartimental Center (CIRM): Director.
2015-2016		- Agenzia Italiana del Farmaco (AIFA; Italian Medicines Agency) national Registry on Natalizumab, scientific committee: member
2016-2020		- European Academy of Neurology - Scientific Panel on Neuroimmunology: co-chairman
2016-2018 2020-2023 2018-2020		- Italian Society of Neurology (Società Italiana Neurologia; SIN), Tuscan regional section: coordinator. - Italian College of the Professors of Neurology: Steering Committee member. - University of Florence College of Discipline: member
2018-2022		- University of Florence/Careggi University Hospital Conflict of Interest Evaluation Committee: member
2020-2024		- University of Florence Academic Senate: Biomedical Area representative.
2021-2025 2020-27 2020- 2023 2023-2023 2024-today 2025-today		- Italian Society of Neurology (Società Italiana Neurologia; SIN), Neuroimmunology Study Group: coordinator - European Academy of Neurology - Scientific Panel on Neuroimmunology: delegate of the Italian Society of Neurology Italian college of the Full professors of Neurology: member of the steering committee. Italian college of the Full professors of Neurology: secretary of the steering committee. University of Florence – Biomedical Imaging Interdipartimental Center (CIRIB): member of the steering committee. Careggi University Hospital Research Support Area: Director

Teaching activity: University of Florence

Year

Teaching Courses

Subject

- 1995-2025,

- 2005-2025,

- 2005-2018,

- 2005-2009,

- 1995-2025,

- 2005-2012,

- 2009-2025,

- 2012-2025

- 2015-2025

- 2018-2025

School of Health Sciences,

Medicine and Surgery program

School of Health Sciences, Dentistry program

School of Health Sciences, Nursery Sciences program.

School of Psychology, Experimental Psychology program.

Resident program in Neurology.

Resident program in Neuro-physio-pathology

Resident program in Emergency Medicine:

Resident program in Neurosurgery

Resident program in Psychiatry

Resident program in Ophthalmology

Clinical Neurology;

Thesis tutorship: n.= 59

Clinical Neurology;

Clinical Neurology

Clinical Neurology;

Clinical Neurology

- 1995-2025

- 2009- 2014

PhD program inNeurosciences,

Member of the Teaching committee;

Coordinator

Thesis tutorship: n= 30

SCIENTIFIC SOCIETY AFFILIATION

- Italian Society of Neurology (Società Italiana di Neurologia; SIN).

- European Academy of Neurology

- Italian Association of Neuroimmunology (Associazione Italiana di Neuroimmunologia; AINI)

- International Society of Neuroimmunology.

REVIEWER FOR:

Journal of Neuroimmunology, Journal Clinical Neurology and Neurosurgery, Neuroscience letters; Journal of Immunology, Neurological Sciences, Plos Medicine, Plos Pathology, Plos One, J. Neurol. Sciences, Neuroepidemiology. Intl. MS journal, Frontiers in Neurology, Frontiers in Immunology, Annals of Clinical and Translational Neurology.

Italian Multiple Sclerosis Foundation, Dutch Multiple Sclerosis Society, Singapore Medical Research Council,

Italian Ministry of University and Research.

Italian Multiple Sclerosis Foundation.

National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA

SCIENTIFIC JOURNAL EDITORIAL BOARD MEMBER:

Past: - Multiple Sclerosis International; - Multiple Sclerosis and Neuroimmunology.

Current: Neuronal Circuits; Frontiers in Neurology, Neurological Sciences.

ANNEXES

PUBLICATIONS

Publications on international Journal quoted in “PubMed”, National Library of Medicine (USA).

Full Papers

Raimondi L., Banchelli Soldaini G., Buffoni F., Ignesti G., Massacesi L., Amaducci L. and Friedmann C.A. (1982). Rhein and derivatives. In vitro studies on their capacity to inhibit certain proteases. Pharmacol. Res. Comm., 14(2): 103-112.
Smith M.E., Somera F.P., Saldivar R., Massacesi L. and Trotter J. (1984). DNA changes in spinal cords of rats with experimental allergic encephalomyelitis.J. Neurochem., 43: 1635-1641.
Massacesi L., Abbamondi A.L., Sarlo F. and Amaducci L. (1987). The control of experimental allergic encephalomyelitis with retinoic acid. Further studies. Riv. Neurol. 57:166-169.
Massacesi L., Abbamondi A.L., Giorgi C., Sarlo F., Lolli F. and Amaducci L. (1987). Suppression of experimental allergic encephalomyelitis by retinoic acid. J. Neurol. Sciences, 80:55-64.
Massacesi L., Abbamondi A.L., Raimondi L., Giorgi C. and Amaducci L. (1988). Lysosomal enzymes in experimental allergic encephalomyelitis: time course and evidence of the source. Neurochem. Res., 13:165-169.
Theoharides TC, Lambrachthall M, Massacesi L, et al. (1990). Reduced incidence of experimental allergic encephalomyelitis (EAE) with the tricyclic sep-ch. Europ. J. Pharmacol., 183: 626-627.
Massacesi L., Castigli E., Vergelli M., Olivotto J., Abbamondi A.L., Sarlo F. and Amaducci L. (1991). Immunosuppressive activity of 13-cis retinoic acid and prevention of experimental autoimmune encephalomyelitis in rats. J.Clin.Invest., 88:1331-1337.
Riskind P., Massacesi L., Doolittle T.H. and Hauser S.L. (1991).The role of prolactin in autoimmune demyelination: suppression of experimental allergic encephalomyelitis by bromocriptine. Ann. Neurol., 29: 542-547.
Zehetbauer B., Massacesi L., Liuzzi G. M., Vergelli M., Olivotto J., Grassi L., Riccio P. and Amaducci L. (1991). Myelin Basic Protein in lipid-bound form induces experimental allergic encephalomyelitis and demyelination in Lewis rat. Acta Neurologica 13: 121-132.
Massacesi L., Parritz D., Joshi N, Letvin N. and Hauser S.L.(1992). Experimental allergic encephalomyelitis in Cynomolgus Monkeys: quantitation of T-cell responses in peripheral blood. J.Clin. Invest., 90: 399-404.
Salvetti M and Massacesi L. (1992). Experimental allergic encephalomyelitis and multiple sclerosis: immunoregulatory mechanisms and T cell repertoires. Cell. Immunol., 142: 217-219.
Salvetti M., Buttinelli C., Massacesi L. and Wekerle H. (1993). New approaches to the study of T-cell autoimmunity in multiple sclerosis. J. Neuroimmunol., 47: 203-205.
Yu J.S., Pandey J. P., Massacesi L., Lincoln R., Usuku K., Seboun E. and Hauser S.L. (1993). Segregation of Immunoglobulin heavy Chain constant region genes in Multiple sclerosis sibling pairs. J. Neuroimmunol., 42: 113-116.
Lolli F., Liuzzi G.M., Vergelli M., Massacesi L., Ballerini C., Amaducci L. and Riccio P. (1993). Antibodies specific for the lipid-bound form of myelin basic protein during experimental autoimmune encephalomyelitis. J. Neuroimmunol., 44: 69-75
Massacesi L., Vergelli M., Zehetbauer B., Liuzzi G.M., Olivotto J., Ballerini C., Uccelli A., Mancardi L., Riccio P. amd Amaducci L. (1993). Induction of experimental autoimmune encephalomyelitis in rats and immune response to myelin basic protein in lipid bound form. J. Neurol. Sciences, 119: 91-98.
Da Vico S., Massacesi L., Amaducci L. (1993). Survey of the italian neurological output in the three years 1989-1991. It J. Neurol. Sci., 14: 595-598.
Genain C.P., Parritz D., Hoa Nguyen M., Massacesi L., Ioshi N., Ferrante R., Hoffman K., Moseley M., Levtin N., Hauser S. (1994). In healthy primates, circulating autoreactive T-cells mediate autoimmune disease. J. Clinic. Invest., 94: 1339-1345.
Vergelli M., Mazzanti B., Ballerini C., Gran B., Amaducci L. and Massacesi L. (1995). Trasforming growth factor-beta1 inhibits the proliferation of rat astrocytes induced by serum and growth factors. J. Neurosc. Res., 40: 127-133.
Massacesi L., Genain C.P., Parritz D.L., Canfield D., Letvin N. and Hauser S.L. (1995). Active and passively induced experimental autoimmune encephalomyelitis in common marmosets: a new model for multiple sclerosis. Ann. Neurol., 37: 519-530.
Hohlfeld R., Londei M., Massacesi L. and Salvetti M. (1995).T-cell autoimmunity in multiple sclerosis. Immunology Today (now Trends in Immunology), 16:259-261.
Amato M.P., Massacesi L. and Amaducci L. (1996). Clinical outcome measurements in Multiple Sclerosis trials. MS Forum. Int. MS Journal 3 n(1) : 19-27.
Vergelli M., Olivotto J., Castigli E., Gran B., Raimondi L., Pirisino R., Amaducci L. and Massacesi L. (1997). Immunosuppressive activity of 13-cis-retinoic acid in rats: Aspects of pharmacokinetics and pharmacodynamics. Immunopharmacol., 37: 191-197.
Mazzanti B. , M. Vergelli, P. Riccio, R. Martin, H.F. McFarland, G.M. Liuzzi, L. Amaducci and Massacesi L. (1998). T cell response to Myelin Basic Protein in patients with Multiple Sclerosis and healthy donors. J. Neuroimmunol., 82: 96-100.
Gran B., Gestri D., Sottini A., Quiròs Roldàn E., Bettinardi A., Signorini S., Primi D., Ballerini C., Taiuti R., Amaducci L. and Massacesi L. (1998). Detection of skewed T-cell receptor V-beta gene usage in the peripheral blood of patients with multiple sclerosis. J. Neuroimmunol., 85: 22-32.
Cascino I., Ballerini C., Audino S., Rombolà G., Massacesi L., Colombo G., Scorza Smeraldi R., D’Alfonso S., Momigliano Richiardi P., Tosi R., Ruberti G. (1998). Fas Gene Polymorphisms are not associated with Systemic Lupus Erythematosus, Multiple Sclerosis and HIV Infection. Disease Markers, 13: 221-225.
Laman J.D., van Meurs M., Schellekens M.M., de Boer M., Melchers B., Massacesi L., Lassmann H., Klaassen E., ‘t Hart B. (1998). Expression of accessory molecules and cytokines in acute EAE in marmoset monkeys (Callithrix jacchus). J. Neuroimmunol., 86: 30-45.
‘t Hart B., Bauer J., Muller H.J., Melchers B., Nicolay K., Brok H., Bontrop R., Lassmann H. and Massacesi L. (1998) Histopathological characterization of magnetic resonance imaging-decectable brain white matter lesions in a primate model of multiple sclerosis. Am. J. Pathol., 153: 649-663.
Kappos, L; Polman, C; Pozzilli, C et al (1998). Placebo-controlled multicentre randomised trial of Interferon beta-1b in treatment of secondary progressive multiple sclerosis. Lancet, 352: 1491-97.
Mazzucco S., Nardi E., Chelli M., Ginanneschi M., Rapi G., Papini A.M., Vergelli M., Mazzanti B., Massacesi L., Amaducci L. (1999). Synthesis of lipopeptides of the immunodominant epitope hMBP(83-99) containing amide or C-C bond linked hydrophobic chains for the study of T cell response. Letters in Peptide Sciences 6: 51-59.
Mazzucco S., Matà S., Vergelli M., Fioresi R., Nardi E., Mazzanti B., Chelli M., Lolli F., Ginanneschi M., Pinto F., Massacesi L. and Papini A.M. (1999). A synthetic glycopeptide of human myelin oligodendrocyte glycoprotein to detect antibody responses in multiple sclerosis and other neurological diseases. Bioorg. Med. Chem. Lett. : 167-172.
Sabbadini M.G., Manfredi AA., Bozzolo E., Ferrario L., Rugarli C., Scorza R., Origgi L., Vanoli M., Gambini O., Vanzulli L., Croce D., Campana A., Messa C., Fazio F., Tincani A., Anzola G., Cattaneo R., Padovani A., Gasparotti R., Gerli R., Quartesan R., Piccirilli M., Farsi A., Emmi E., Domeneghetti M., Piccini C., Massacesi L., Pupi A., De Cristoforis M., Danieli M., Candela M., Fraticelli P., Bartolini M., Savolini U., Danieli G. and Passaleva A. (1999). Central Nervous system involvement in Systemic Lupus Eritematosus patients without overt neuropsychiatric manifestations. Lupus 8: 11-19.
D’Alfonso S., Nisticò L., Zavattari P., Marrosu M., Murru R., Lai M., Massacesi L., Ballerini C., Gestri D., Salvetti M., Ristori G., Bomprezzi R., Trojano M., Liguori M., Gambi D., Quattrone A., Fruci D., Cucca F., Momigliano Richiardi P. and Tosi R. (1999). A linkage analysis of Multiple Sclerosis with candidate region markers in Sardinian and Continental Italian families. Eur. J Hum.Gen. 7 : 377-385.
Miller D.H., Molyneux P.D., Barker G.J., Mac Manus D.G., Moseley I.F., Wagner K.,and the European Study Group on Interferon-Beta1b in Secondary Progressive Multiple Sclerosis. (1999) Effect of Interferon-Beta1b on Magnetic Resonance Imaging Outcomes in Secondary Progressive Multiple Sclerosis: Results of a European Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial. Ann. Neurol., vol. 46, 850-859.
Ballerini C. Nacmias B., Rombolà G., Marcon G., Massacesi L., Sorbi S. (1999) HLA A2 Allele Is Associated with Age at Onset of Alzheimer’s Disease. Ann. Neurol., vol. 45: 397-400.
Mazzanti B., Hemmer B., Traggiai E., Ballerini C., McFarland H.F., Massacesi L., Martin R. and Vergelli M. (2000). Decrypting the Spectrum of Antigen-Specific T-Cell Responses: The Avidity Repertoire of MBP-Specific T-Cells. J. Neurosci. Res., 59:86-93.
‘t Hart B.A., van Meurs M., Brok H.P.M., Massacesi L., Bauer J., Boon L., Bontrop R.E and Laman J.D. (2000). A new primate model for multiple sclerosis in the common marmoset. Immunology Today (ora Trends in Immunology), 21: 290-297.
Pupi A., Sestini S., De Cristofaro M.T., Emmi L., Marchione T., Salvati G., Li Gobbi F., Massacesi L., Meldolesi U. (2000). Use of technetium-99mhexametylpropyleneamine oxime single-photon emission tomography for the study of cerebral blood flow reactivity after acetazolamide infusion in patients with Behcet’s disease. Eur. J. Nucl. Med. 27(6): 700-706.
D’Alfonso S., Nisticò L., Bocchio D., Bomprezzi R., Marrosu M.G., Murru M.R., Lai M., Massacesi L., Ballerini C., Repice A., Solvetti M., Montesperelli C., Ristori G., Trojano M., Liguori M., Gambi D., Quattrone A., Tosi R., Momigliano-Richiardi P. (2000). An attempt of identifying MS-associated loci as a follow-up of a genomic linkage study in the Italian population. J. Neurovirol. 6 (S 2):18-22.
Molyneux P.D., Kappos L., Polman C., Pozzilli C., Barkhof F., Filippi M., Yousry T., Hahn D., Wagner K., Ghazi M., Beckmann K., Dalhke F., Losseff N., Barker G.J., Thompson A.J., Miller D.H. and the European Study Group on Interferon beta-1b in Secondary Progressive Multiple Sclerosis (2000). The effect of interferon beta-1b treatment on MRI measures of cerebral atrophy in secondary progressive multiple Sclerosis. Brain 123: 2256-2263.
Ballerini C., Campani D., Rombolà G., Gran B., Nacmias B., Amato M.P., Siracusa G., Bartolozzi L., Sorbi S. and Massacesi L. (2000). Association of apolipoprotein E polymophism to clinical heterogeneity of multiple sclerosis. Neurosci. Lett. 296: 174-176.
Papini AM, Mulinacci B, Carotenuto A, Bonetti B, Sabatino G, Peron E, Nuti F, Alcaro MC Pozo-Carrero MC, Mazzanti, B, Pazzagli m, Massacesi L, Battistini L, Chelli, M, Rovero, P, Lolli, F, Chorev M, Sawyer, TK, 2001. MS PepKit: The first diagnostic test to follow-up multiple sclerosis. Peptide Revolution: Genomics, Proteomics & Therapeutics
Chiarugi A., Cozzi A., Ballerini C., Massacesi L. and Moroni F. (2001). Kynurenine 3-monoxygenase activity and neurotoxic kynurenine metabolites increase in the spinal cord of rats with experimental allergic encephalomyelitis. Neuroscience 102: 687 - 695.
Mancardi G., t’Hart B., Roccatagliata L., Brok H., Giunti D., Bontrop R., Massacesi L., Capello E. and Uccelli A. (2001.) Demyelination and axonal damage in a non-human primate model of multiple sclerosis. J. Neurol. Sciences 184: 41-49.
Gestri D., Baldacci L., Taiuti R., Galli E., Maggi E., Piccinni M.P., Vergelli M. and Massacesi L. (2001). Oligoclonal T-cell repertoire in cerebrospinal fluid of patients with nervous system inflammatory diseases. J. Neurol. Neurosurg. Psych. 70: 767- 772.
Broadley S., Sawcer S., D'Alfonso S., Henseik A., Coraddu F., Gray J., Roxburgh R., Clayton D., Buttinelli C., Quattrone A, Trojano M., Momigliano Richiardi P. , Massacesi L. and Compston A. (2001). A genome screen for multiple sclerosis in Italian families. Genes Immun. 2: 205-10.
Mancardi G.L., Saccardi, R., Filippi, M., Gualandi F., Murialdo A., Inglese M., Marrosu M.G., Meucci G., Massacesi L., Lugaresi A., Pagliai F., Sormani M.P., Sardanelli F., Marmont A. and the Italian Gitmo-Neuro Intergroup on Autologous Hematopoietic Stem Cell Transplantation for Multiple Sclerosis (2001). Autologous hematopoietic stem cell transplantation suppresses Gadolinium-enhanced MRI activity in multiple sclerosis. Neurology 57:62-68.
Papini A.M., Mazzanti B., Nardi E., Traggiai E., Ballerini C., Biagioli T., Kalbacher H., Beck H., Deeg M., Chelli M., Ginanneschi M., Massacesi L., Vergelli M. (2001). Palmitoyl Derivatives of GpMBP Epitopes: T-Cell Response and Peptidases Susceptibility. J. Med. Chem 44: 3504- 3510.
Soldan S. S., Fogdell-Hahn A., Brennan M. B., Mittleman B. B., Ballerini C., Massacesi L., Seya T., McFarland H. F. and Jacobson S. (2001). Elevated serum and CSF levels of soluble HHV-6 cellular receptor, membrane cofactor protein (MCP; CD46), in patients with multiple sclerosis. Ann. Neurol. 50: 486-93.
Vergelli M., B. Mazzanti, E. Traggiai, T. Biagioli, C. Ballerini, A Parigi, G. Pellicanò, A. Konze, Massacesi L (2001). Short-term evolution of autoreactive T-cell repertoire in multiple sclerosis. J Neurosci Res. 66:517-24.
Traggiai E., Biagioli T., Rosati E., Ballerini C., Mazzanti B., Ben Nun A., Massacesi L., Vergelli M. (2001). IL-7-enhanced T-cell response to myelin proteins in multiple sclerosis. J. Neuroimmunol. 121:111-9.
Kappos L., Polman C., Pozzilli C., Thompson A., Beckmann K., Dalhke F., and the European Study Group on Interferon beta-1b in Secondary Progressive Multiple Sclerosis (2001). Final analysis of the European multicenter trial on IFNbeta-1b secondary progressive Multiple Sclerosis. Neurology 57: 1969-1975.
Freeman J, Thompson A., Fitzpatrick R., Hutchinson M., Miltenburger C., Beckmann K., Kappos L., Dalhke F., Polman C., Pozzilli C., and the European Study Group on Interferon beta-1b in Secondary Progressive Multiple Sclerosis (2001). IFNbeta-1b in the treatment of secondary progressive Multiple Sclerosis. Impact on quality of life. Neurology 57: 1870-1875.
Molyneux PD, Barker GJ, Barkhof F, Beckmann K, Dahlke F, Filippi M, Ghazi M, Hahn D, MacManus D, Polman C, Pozzilli C, Kappos L, Thompson AJ, Wagner K, Yousry T, Miller DH; European Study Group on Interferon Beta-1b in Secondary Progressive MS (2001). Clinical-MRI correlations in a European trial of interferon beta-1b in secondary progressive MS.Neurology 57: 2191-7.
D'Alfonso S., Mellai M., Giordano M., Pastore A., Malferrari G., Naldi P., Repice A., Liguori M., Cannoni S., Milanese C., Caputo D., Savettieri G., Momigliano-Richiardi P. and the Italian Group for the Study of Multiple Sclerosis Genetics(2002). Identification of single nucleotide variations in the coding and regulatory regions of the myelin-associated glycoprotein gene (MAG) and study of their association with multiple sclerosis. J. Neuroimmunol. 126 : 196-204.
Muraro, P.A., Bonanni, L., Mazzanti B., Pantalone, A., Traggiai, E., Massacesi L., Vergelli, M., Gambi, D. (2002). Short-term dynamics of circulating T cell receptor V beta repertoire in relapsing-remitting MS. J. Neuroimmunol. 127: 149-59.
Massacesi L. (2002). Compartmentalization of the immune response in the central nervous system and natural history of multiple sclerosis. Implications for therapy. Clin Neurol Neurosurg 104: 177-81.
Ballerini C., Rosati E., Salvetti M., Ristori G., Cannoni S., Biagioli T., Massacesi L., Sorbi S., Vergelli M. (2002). PTPRC exon 4 gene mutation distribution in a Italian MS population. Neuroscience Letters 328: 325-7.
Buzzetti R., Pozzilli P., Di Mario U., Ballerini C., and Massacesi L. (2002). Multiple sclerosis and Type I diabetes. Diabetologia 45: 1735-6.
Mellai M., Giordano M., D’Alfonso S., Marchini M., Scorza R., Danieli M.G., Leone M., Ferro I., Liguori M., Trojano M., Ballerini C., Massacesi L., Cannoni S., Bomprezzi R., Momigliano-Richiardi P. (2003). Prolactin and prolactin receptor gene polymorphisms in multiple sclerosis and systemic lupus erythematosus. Human Immunol. 64: 274-284.
Polman C, Kappos L, White R, Dahlke F, Beckmann K, Pozzilli C, Thompson A, Petkau J, Miller D; European Study Group in Interferon Beta-1b in Secondary Progressive MS (2003). Neutralizing antibodies during treatment of secondary progressive MS with interferon beta-1b. Neurology 60: 37-43.
Sormani MP, Bruzzi P, Beckmann K, Wagner K, Miller DH, Kappos L, Filippi M; European Study Group on Interferon Beta-1b in Secondary Progressive MS (2003). MRI metrics as surrogate endpoints for EDSS progression in SPMS patients treated with IFN beta-1b. Neurology 60: 1462-6.
Alizadeh M, Babron MC, Birebent B, Matsuda F, Quelvennec E, Liblau R, Cournu-Rebeix I, Momigliano-Richiardi P, Sequeiros J, Yaouanq J, Genin E, Vasilescu A, Bougerie H, Trojano M, Martins Silva B, Maciel P, Clerget-Darpoux F, Clanet M, Edan G, Fontaine B, Semana G. (2003) and the Portuguese and Italian Group for MS genetics. Genetic interaction of CTLA-4 with HLA-DR15 in multiple sclerosis patients. Ann Neurol. 54:119-22.
Akesson E, Coraddu F, Marrosu MG, Massacesi L, Hensiek A, Harbo HF, Oturai A, Trojano M, Momigliano-Richiardi P, Cocco E, Murru R, Hillert J, Compston A and Sawcer S (2003). Refining the linkage analysis on chromosome 10 in 449 sib-pairs with multiple sclerosis. J Neuroimmunol.143: 31- 38.
Liguori M, Sawcer S, Setakis E, Compston A, Giordano M, D'Alfonso S, Mellai M, Malferrari G, Trojano M, Livrea P, De Robertis F, Massacesi L, Repice A, Ballerini C, Biagioli T, Bomprezzi R, Cannoni S, Ristori G, Salvetti M, Grimaldi LM, Biunno I, Comi G, Leone M, Ferro I, Naldi P, Milanese C, Gellera C, Loredana LM, Savettieri G, Salemi G, Aridon P, Caputo D, Rosa Guerini F, Ferrante P, and Momigliano-Richiardi P (2003). A whole genome screen for linkage disequilibrium in multiple sclerosis performed in a continental Italian population. J Neuroimmunol. 143: 97-100.
Ballerini C, Guerini F, Rombolà G, Rosati E, Massacesi L, Ferrante P, Caputo D, Figà Talamanca L, Naldi P, Liguori M, Alizadeh M, Momigliano-Richiardi P, D’Alfonso S (2004). HLA-Multiple Sclerosis association in Continental Italy and correlation with disease prevalence in Europe. J Neuroimmunol. 150:178 -85.
IngleseM, G L Mancardi, E Pagani, M A Rocca, A Murialdo, R Saccardi, G Comiand M Filippi the Italian GITMO-NEURO Intergroup on Autologous Hemotopoietic Stem Cell Transplantation (2004).Brain tissue loss occurs after suppression of enhancement in patients with multiple sclerosis treated with autologous haematopoietic stem cell transplantation. J. Neurol. Neurosurg. Psych. 75: 643-644.
Saccardi R, Mancardi GL, Solari A, Bosi A, Bruzzi P, Di Bartolomeo P, Donelli A, Filippi M, Guerrasio A, Gualandi F, La Nasa G, Murialdo A, Pagliai F, Papineschi F, Scappini B, Marmont AM. and the Italian GITMO-NEURO Intergroup on Autologous Hemotopoietic Stem Cell Transplantation (2005). Autologous HSCT for severe progressive multiple sclerosis in a multicenter trial: impact on disease activity and quality of life. Blood. 105:2601-7.
MazzantiB, Biagioli T., Aldinucci A., Cavaletti G., CavalettiE., Crippa L., Oggioni N.,Sala F., Sala V., Frigo M., Rota S., Tagliabue E., Ballerini C., Massacesi L., Riccio P. and Lolli F. (2005). Effects of Pixantrone on T- and B-cell function in the course of acute rat experimental allergic encephalomyelitis. J. Neuroimmunol. 168: 111-117.
Capello E, Saccardi R, Murialdo A, Gualandi F, Pagliai F, Bacigalupo A, Marmont A, Uccelli A, Inglese M, Bruzzi P, Sormani MP, Cocco E, Meucci G, Massacesi L, Bertolotto A, Lugaresi A, Merelli E, Solari A, Filippi M, Mancardi GL; Italian GITMO-Neuro Intergroup on ASCT for Multiple Sclerosis (2005). Intense immunosuppression followed by autologous stem cell transplantation in severe multiple sclerosis. Neurol Sci. 26: S200-3.
Massacesi L, Parigi A, Barilaro A, Repice AM, Pellicanò G, Konze A, Siracusa GF, Taiuti R and Amaducci L. (2005). Efficacy of Azathioprine on Multiple Sclerosis new brain lesions evaluated by Magnetic Resonance Imaging. Arch.Neurol.;62:1843-1847
Ristori G, Cannoni S, Stazi MA, Vanacore N, Cotichini R, Alfo M, Pugliatti M, Sotgiu S, Solaro C, Bomprezzi R, Di Giovanni S, Figa Talamanca L, Nistico L, Fagnani C, Neale MC, Cascino I, Giorgi G, Battaglia MA, Buttinelli C, Tosi R, Salvetti M. and the Italian MS genetic collaborative group (2006). Multiple sclerosis in twins from continental Italy and Sardinia: A nationwide study. Ann Neurol.59(1):27-34.
The GAMES Collaborative Group, Ban M, Booth D, Heard R, Stewart G, Goris A, Vandenbroeck K, Dubois B, Laaksonen M, Ilonen J, Alizadeh M, Edan G, Babron MC, Brassat D, Clanet M, Cournu-Rebeix I, Fontaine B, Semana G, Goedde R, Epplen J, Weber A, Infante-Duarte C, Zipp F, Rajda C, Bencsik K, Vécsei L, Heggarty S, Graham C, Hawkins S, Liguori M, Momigliano-Richiardi P, Caputo D, Grimaldi LM, Leone M, Massacesi L, Milanese C, Salvetti M, Savettieri G, Trojano M, Bielecki B, Mycko MP, Selmaj K, Santos M, Maciel P, Pereira C, Silva A, Silva BM, Coraddu F, Marrosu MG, Akesson E, Hillert J, Datta P, Oturai A, Harbo HF, Spurkland A, Goertsches R, Villoslada P, Eraksoy M, Hensiek A, Compston A, Setakis E, Gray J, Yeo TW, Sawcer S. (2006). Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans. J. Neuroimmunol.179: 108-116.
Saccardi R, Kozak T, Bocelli-Tyndall C, Fassas A, Kazis A, Havrdova E, Carreras E, Saiz A, Löwenberg B, te Boekhorst P, GualandiF, Openshaw H, Longo G, Pagliai F, Massacesi L, Deconink E, Ouyang J, Zuazu Nagore F, Besalduch J, Lisukov I, Bonini A, Merelli E,Slavin S, Gratwohl A, Passweg J, Tyndall A, Steck A, Andolina M, Capobianco M, Diez Martin J, Lugaresi A,Meucci G, Sáez R,Clark R, Fernandez M, Fouillard L, Herstenstein B, Koza V, Cocco E, Baurmann H and Mancardi G on behalf of the Autoimmune Disease Working Party of EBMT (2006). Autologous stem cell transplantation for progressive multiple sclerosis: update of the European group for blood and marrow transplantation auto-immune diseases working party database. Mult. Sclerosis J 12: 814-823.
Roccatagliata L, Rocca M, Valsasina P, Bonzano L, Sormani M, Saccardi R, Mancardi G, Filippi M; for the Italian GITMO-NEURO Intergroup on Autologous Stem Cell Transplantation. (2007). The long-term effect of AHSCT on MRI measures of MS evolution: a five-year follow-up study. Mult Sclerosis. 13: 1068-70.
Aldinucci A., Gerlini G., Fossati S., Cipriani G., Ballerini C., Biagioli T., Pimpinelli N., Borgognoni L., Massacesi L., Moroni F. and Chiarugi A. (2007). Requirement for PARP-1 activity during human dendritic cell maturation. J. Immunol. 179: 305-12.
D’Alfonso S., Bolognesi E., Guerini F., Barizzone N., Bocca S., Castelli L., Bergamaschi L., Agliardi C., Ferrante P., Naldi P., Leone M., Caputo D., Ballerini C., Salvetti M., Galimberti D., Massacesi L., Trojano M., Momigliano-Richiardi P. (2008). A sequence variation in the MOG gene is involved in Multiple Sclerosis susceptibility in Italy. Genes and Immun 9: 7-15.
Luccarini I., Ballerini C., Biagioli T., Biamonte F., Bellucci A., Rosi M.C., Grossi C., Massacesi L. and Casamenti F. (2008). Combined treatment with atorvastatin and minocycline suppresses severity of EAE. Exp. Neurol., 211: 214.
Mazzanti B., Aldinucci A., Biagioli T., Barilaro A., Urbani S., Dal Pozzo S., Amato MP, Siracusa GF., Crescioli C., Manuelli A., Bosi A., Saccardi R., Massacesi L. and Ballerini C. (2008). Differences in mesenchymal stem cell cytokine profiles between MS patients and healthy donors: Implication for assessment of disease activity and treatment. J. Neuroimmunol. 199:142-50.
’t Hart B. and Massacesi L(2009). Clinical, pathological and immunological aspects of the multiple sclerosis model in common marmosets (Callithrix jacchus). J. Neuropath.Exp.Neurol. 68 (4): 341-355.
Bizzoco E, Lolli F, Repice A, Falcini M, Taiuti R, Siracusa GF, Amato MP, Biagioli T, Lori S, Moretti M, Vinattieri A, Nencini P, Massacesi L, Matà S. (2009). Prevalence of Neuromyelitis Optica Spectrum Disorder and Phenotype Distribution. J. Neurol. 256:1891-8
Aldinucci A, Biagioli T, Manuelli C, Repice A, Massacesi L, Ballerini C. (2010). Modulating dendritic cells (DC) from immunogenic to tolerogenic responses: a novel mechanism of AZA/6-MP. J. Neuroimmunol, 218:28-35.
Aldinucci A, Rizzetto L, Pieri L, Nosi D, Romagnoli P, Biagioli T, Mazzanti B, Saccardi R, Beltrame L, Massacesi L, Cavalieri D, Ballerini C (2010). Inhibition of Immune Synapse by Altered Dendritic Cell Actin Distribution: A New Pathway of Mesenchymal Stem Cell Immune Regulation. J. Immunol. 185:5102-10.
Gaitán M, SheaC, Evangelou I, Stone R, Fenton K, Bielekova B, Massacesi L, Reich D. (2011). Evolution of the Blood-Brain Barrier in Newly Forming Multiple Sclerosis Lesions. Ann. Neurol. 70: 22-29.
Gaitán M; Shea C; Evangelou I; Stone R; Fenton K; Bielekova B; Massacesi L; Reich D. (2011). Reply. Ann. Neurol., 70: 669-670.
Snowden JA, Saccardi R, Allez M, Ardizzone S, Arnold R, Cervera R, Denton C, Hawkey C, Labopin M, Mancardi G, Martin R, Moore JJ, Passweg J, Peters C, RabusinM, RoviraM, van Laar JM & Farge D on behalf of the EBMT Autoimmune Disease, (2011). Haematopietic stem cells transplantation (HSCT) in severe autoimmune diseases: updated guidelines of the European group for bone marrow transplantation (EBMT). Bone marrow Transplantation
MancardiG, Sormani M, Di Gioia M, Vuolo L, Gualandi F, Amato M, Capello E, Currò D, Uccelli A, Bertolotto A, Gasperini C, Lugaresi A, Merelli E, Meucci G, Motti L, Tola M, Scarpini E, Repice A, Massacesi L, Saccardi R. (2012) Autologous haematopoietic stem cell transplantation with an intermediate intensity conditioning regimen in multiple sclerosis: the Italian multi-centre experience. Mult Scler. J. 18: 835-842.
Lutterotti A, Jelcic I, Schulze C, Schippling S, Breiden P, Mazzanti B, Reinhard S, DiGioia M, Repice A, Massacesi L, Sputtek A, Salinas-Riester G, Kroeger N, Sospedra M, Saccardi R, Zander A and Martin R (2012). Gene expression and epigenetic profiling of CD34+ hematopoietic progenitor cells in multiple sclerosis patients – absence of proinflammatory signatures.Mult Scler. .
Saccardi R, Freedman MS, Sormani MP, Atkins H, Farge D, Griffith LM, Kraft G, Mancardi GL, Nash R, Pasquini M, Martin R, Muraro PA; European Blood and Marrow Transplantation Group; Center for International Blood and Marrow Research; HSCT in MS International Study Group (2012). A prospective, randomized, controlled trial of autologous haematopoietic stem cell transplantation for aggressive multiple sclerosis: a position paper. Mult Scler. Jun;18(6):825-34.
Zamboni P, Bertolotto A, Boldrini P, Cenni P, D'Alessandro R, D'Amico R, Del Sette M, Galeotti R, Galimberti S, Liberati A, Massacesi L, Papini D, Salvi F, Simi S, Stella A, Tesio L, Valsecchi MG, Filippini G. (2012). Efficacy and safety of venous angioplasty of the extracranial veins for multiple sclerosis. Brave Dreams Study (Brain Venous Drainage Exploited Against Multiple Sclerosis): study protocol for a randomized controlled trial. Trials 13: 183-196.
Carrai V, Donnini I, Mazzanti B, Alterini R, Amato MP, Barilaro A, Bosi A, Massacesi L, Portaccio E, Repice AM, Rotunno G and Saccardi R. (2013).Immunohistochemistry analysis of bone marrow biopsies in multiple sclerosis patients undergoing autologous hematopoietic stem cells transplantarion. Clin. Neurol. and Neurosurg. 115: 1044 – 1048
Aldinucci A, Turco A, Biagioli T, Toma F, Bani D, Guasti D, Manuelli C, Rizzetto L, Cavalieri D, Massacesi L, Mello T, Scaini D, Bianco A, Ballerini L, Prato M, Ballerini C (2013). Carbon nanotube scaffolds instruct human dendritic cells: modulating immune responses by contacts at the nanoscale. Nano Letters 13(12):6098-105.
Paganini M, Biggeri A, Romoli AM, Mechi C, Ghelli E, Berti V, Pradella S, Bucciantini S, Catelan D, Saccardi R, Lombardini L, Mascalchi M, Massacesi L, Porfirio B, Di Lorenzo N, Vannelli GB, Gallina P (2014). Foetal striatal grafting slows motor and cognitive decline of Huntington’s disease. J.Neurol.Neurosurg.Psich. 85: 974-981.
Mascalchi M, Ginestroni A, Toschi N, Poggesi A, Cecchi P, Salvadori E,Tessa C, Cosottini M,De Stefano N, Pracucci G,Pantoni L, Inzitari D, Diciotti S and VMCI Tuscany investigators. (2014).The burden of microstructural damage modulates cortical activation in elderly subjects with MCI and leuko-araiosis. A DTI and fMRI study. Human Brain Mapping35: 819–830.
Gaitan M, Maggi P, Wholer N, Leibowitch M, Sati P, Calandri B, Merkle L, Massacesi L, Silva A, Jacobson S, Rech D. (2014) Perivenular Brain lesions in a primate multiple sclerosis model at 7-tesla MRI. Mult. Scler. 20(1):64–71.
Maggi P, Cummings Macri S, Gaitán M, Leibovitch E, Wohler J, Knight H, Ellis M, Wu T, Silva A, Massacesi L, Jacobson S, Westmoreland S, Reich D (2014). The formation of inflammatory demyelinated lesions in cerebral white matter. Ann. Neurol. 76:594-608.
Massacesi L, Tramacere I, Amoroso S, Battaglia M, Benedetti MD, Filippini G, La Mantia L, Repice A M, Solari A, Tedeschi G, Milanese C (2014). Azathioprine versus Beta Interferons for relapsing-remitting multiple sclerosis: a multicentre randomized non-inferiority trial. PlosOne, 9(11):e113371; e-Pub, November 17 2014.
Bonechi E, Aldinucci A, Mazzanti B., DiGioia M, Repice A, Manuelli C, Saccardi R, Massacesi L, Ballerini C, (2014). Increased CXCL10 expression in Multiple Sclerosis MSCs and monocytes is unaffected by AHSCT. Ann Clin Transl Neurol, 1:650-8.
Laroni A, Brogi D, Morra VB, Guidi L, Pozzilli C, Comi G, Lugaresi A, Turrini R, Raimondi D, Uccelli A, Mancardi GL, EAP Investigators (2014). Safety of the first dose of fingolimod for multiple sclerosis: results of an open-label clinical trial. BMC Neurol. 14:65.
Gallina P, Paganini M, Lombardini L, Biggeri A, Marini M, Morelli AM, Bucciantini S, Sarchielli E, Ambrosini S, Mechi C, Romoli AM, Ghelli E, Pradella S, Urbani S, Mazzanti B, Berti V, Giordano GP, Campolo M, Dal Pozzo S, Piacentini S, Saccardi R, Massacesi L, Mascalchi M, Bosi A, Conti R, Porfirio B, Di Lorenzo N, Vannelli GB,(2014). Trapianto intracerebrale di striato fetale nella malattia di Huntington: un aggiornamento dell'esperienza clinica italiana. Trapianti 18: 5-11.
Salvadori E, Poggesi A, Valenti R, Pracucci G, Pescini F, Pasi M, Nannucci S, Marini S, Del Bene A, Ciolli L, Ginestroni A, Diciotti S, Orlandi G, Di Donato I, De Stefano N, Cosottini M, Chiti A, Federico A, Dotti MT, Bonuccelli U, Inzitari D, Pantoni L and the VMCI-Tuscany Study Group(2015). Development and psychometric properties of a neuropsychological battery for mild cognitive impairment with small vessel disease: the VMCI-Tuscany Study. J Alzheimers Dis. 43: 1313-23.
Maggi P, Mazzoni L, Moretti M, MassacesiL (2015). SWI enhances vein detection usung gadolinium in multiple sclerosis. Acta Radiologica Open. 4:2047981614560938.
Clausi V, Giannecchini S,Magnani E, Repice A, Mechi C, Martelli F, Azzi A, Massacesi L. (2015).Markers of JC Virus Infection in Multiple Sclerosis Patients Under Natalizumab Therapy. Neurology Neuroimmunol Neuroinflamm. 2: e58.
Mancardi GL, Sormani MP, Gualandi F, Saiz A, Carreras E, Merelli E, Donelli A, Lugaresi A, Di Bartolomeo P, Rottoli MR, Rambaldi A, Amato MP, Massacesi L, Di Gioia M, Vuolo V, Currò D, Roccatagliata L, Filippi M, Aguglia U, Iacopino P, Farge D, and Saccardi R. (2015). Autologous Haematopoietic Stem Cell Transplantation in Multiple Sclerosis: a phase II trial. Neurology. 84:981-8.
Giovannelli I, Martelli F, Repice AM, Massacesi L, Azzi A and Giannecchini S (2015). Detection of JCPyV microRNA in Blood and urine samples of multiple sclerosis patients under natalizumab therapy. J. of Neurovirology, 21: 666-70.
Capobianco M, Lo Re M, Sangalli F, Moiola L, Perini P, Gallo P, Danni M, Provinciali L, Repice AM, Massacesi L, Messina S, Patti F, Laroni A, Mancardi GL, Pucci E, Calabrese M and Bertolotto A (2015). Cyclophosphamide Pulse Therapy after Natalizumab Discontinuation for Multiple Sclerosis: a multicenter study. J Mult Scler (Foster City) 2:151.
Maggi P, Sati P, Massacesi L. (2016). Magnetic resonance imaging of experimental autoimmune encephalomyelitis in the common marmoset. J Neuroimmunol. 304:86-92.
Lagi F, Bartalesi F, Pecile P, Biagioli T, Caldini AL, Fanelli A, Giannazzo G, Grifoni S, Massacesi L, Bartoloni A, Rossolini GM. (2016). Proposal for a New Score-Based Approach To Improve Efficiency of Diagnostic Laboratory Workflow for Acute Bacterial Meningitis in Adults. J Clin Microbiol. 54:1851-4.
Montanari E, Rottoli M, Maimone D, Confalonieri P, Plewnia K, Frigo M, Francia A, Pala A, Losignore NA, Ragonese P, Veneziano A; POSIDONIA study group. (2016). A 12-month prospective, observational study evaluating the impact of disease-modifying treatment on emotional burden in recently-diagnosed multiple sclerosis patients: The POSIDONIA study. J Neurol Sci. 15;364:105-9.
Salvadori E, Poggesi A, Valenti R, Pracucci G, Pescini F, Pasi M, Nannucci S, Marini S, Del Bene A, Ciolli L, Ginestroni A, Diciotti S, Orlandi G, Di Donato I, De Stefano N, Cosottini M, Chiti A, Federico A, Dotti MT, Bonuccelli U, Inzitari D, Pantoni L; VMCI-Tuscany Study Group (2016). Operationalizing mild cognitive impairment criteria in small vessel disease: the VMCI-Tuscany Study. Alzheimers Dement. 2016 Apr;12(4):407-18.
Sati P, Oh J, Constable RT, Evangelou N, Guttmann CR, Henry RG, Klawiter EC, Mainero C, Massacesi L, McFarland H, Nelson F, Ontaneda D, Rauscher A, Rooney WD, Samaraweera AP, Shinohara RT, Sobel RA, Solomon AJ, Treaba CA, Wuerfel J, Zivadinov R, Sicotte NL, Pelletier D, Reich DS; NAIMS Cooperative (2016).The central vein sign and its clinical evaluation for the diagnosis of multiple sclerosis: a consensus statement from the North American Imaging in Multiple Sclerosis Cooperative. Nat Rev Neurol. 12:714-722.
Cadavid D, Balcer L, Galetta S, Aktas O, Ziemssen T, Vanopdenbosch L, Frederiksen J, Skeen M, Jaffe GJ, Butzkueven H, Ziemssen F, Massacesi L, Chai Y, Xu L, Freeman S; RENEW Study Investigators (2017). Safety and efficacy of opicinumab in acute optic neuritis (RENEW): a randomised, placebo-controlled, phase 2 trial. Lancet Neurol. 16:189-199.
Muraro P, Pasquini M, Atkins HL, Bowen JD, Farge D, Fassas A, Freedman MS, Georges GE, Gualandi F, Hamerschlak N, Havrdova E, Kimiskidis VK, Kozak T, Mancardi GL, Massacesi L, Moraes DA, Nash RA, Pavletic S, Ouyang J, Rovira M, Saiz A, Simoes B, Trnený M, Zhu L, Badoglio M, Zhong X, Sormani MP, Saccardi R. Multiple Sclerosis–Autologous Hematopoietic Stem Cell Transplantation (MS-AHSCT) Long-term Outcomes Study Group (2017). Long-term Outcomes After Autologous Hematopoietic Stem Cell Transplantation for Multiple Sclerosis. JAMA Neurol. 74:459-469.
Forci B, Mariottini A, Mechi C, Massacesi L, Repice A. (2017).Disease reactivation following fingolimod withdrawal in multiple sclerosis: Two case reports. Mult Scler Relat Disord. 2017 Jul;15:24-26.
ZamboniP, TesioL, GalimbertiS, Massacesi L, SalviF, D’AlessandroR, CenniP, GaleottiR, PapiniD,D’AmicoR, SimiS, ValsecchiMG, FilippiniG and the Brave Dreams Research Group (2018). Efficacy and safety of extracranial vein angioplasty in multiple sclerosis: a randomized clinical trial. JAMA Neurol., 75:35-43.
Maggi P, Absinta M, GrammaticoM, Vuolo L, EmmiG, Carlucci G, Spagni G, Barilaro A, Repice AM, Emmi L, Prisco D, Martinelli V, Scotti R, Sadeghi N, Perrotta G, Sati P, Dachy B, Reich DS, Filippi M, Massacesi L. (2018). The central vein sign differentiates multiple sclerosis from CNS inflammatory vasculopathies. Ann Neurol, 83:283-294.
Kapoor R, Ho PR, Campbell N, Chang I, Deykin A, Forrestal F, Lucas N, Yu B, Arnold DL, Freedman MS, Goldman MD, Hartung HP, Havrdová EK, Jeffery D, Miller A, Sellebjerg F, Cadavid D, Mikol D, Steiner D; ASCEND investigators (2018) Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND): a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension. Lancet Neurol. 17:405-415.
Cadavid D, Balcer L, Galetta S, Aktas O, Ziemssen T, Vanopdenbosch LJ, Leocani L, Freedman MS, Plant GT, Preiningerova JL, Ziemssen F, Massacesi L, Chai Y, Xu L; RENEW Study Investigators. (2018). Predictors of response to opicinumab in acute optic neuritis. Annals of Clinical and Translational Neurology.15;5(10):1154-1162.
D'Amore A, Tessa A, Casali C, Dotti MT, Filla A, Silvestri G, Antenora A, Astrea G, Barghigiani M, Battini R, Battisti C, Bruno I, Cereda C, Dato C, Di Iorio G, Donadio V, Felicori M, Fini N, Fiorillo C, Gallone S, Gemignani F, Gigli GL, Graziano C, Guerrini R, Gurrieri F, Kariminejad A, Lieto M, Marques LourenḈo C, Malandrini A, Mandich P, Marcotulli C, Mari F, Massacesi L, Melone MAB, Mignarri A, Milone R, Musumeci O, Pegoraro E, Perna A, Petrucci A, Pini A, Pochiero F, Pons MR, Ricca I, Rossi S, Seri M, Stanzial F, Tinelli F, Toscano A, Valente M, Federico A, Rubegni A, Santorelli FM. (2018). Next Generation Molecular Diagnosis of Hereditary Spastic Paraplegias: An Italian Cross-Sectional Study.Front Neurol. 9:981.
Trojano M, Bergamaschi R, Amato MP, Comi G, Ghezzi A, Lepore V, Marrosu MG, Mosconi P, Patti F, Ponzio M, Zaratin P, Battaglia MA^,(2018). Italian Multiple Sclerosis Register Centers Group. The Italian multiple sclerosis register. Neurol Sci. 40(1):155-165.
Mariottini A, Innocenti C, Forci B, Magnani E, Mechi C, Barilaro A, Nistri R, Fani A, Saccardi R, Massacesi L, Repice AM (2019). Safety and efficacy of autologous hematopoietic stem cell transplantation following natalizumab discontinuation in aggressive Multiple Sclerosis. Eur J Neurol. 26(4):624-630
Maggi P, Absinta M, Sati P, Perrotta G, Massacesi L, Dachy B, Pot C, Meuli R, Reich DS, Filippi M, Pasquier RD, Théaudin M (2019). The "central vein sign" in patients with diagnostic "red flags" for multiple sclerosis: A prospective multicenter 3T study. Mult Scler J.
Pasca M, Picchioni A, Mazzeo S, Terenzi F, Prestipino E, Fratangelo R, Repice AM,Carlucci G, Massacesi L, Barilaro A (2019). A Case of Recurrent Progressive Multifocal Leukoencephalopathy After Human Stem Cell Transplant, With Detection of John Cunningham Virus and Human Herpesvirus 6 on Cerebrospinal Fluid, Treated With Mirtazapine, Olanzapine and Foscarnet. Intractable Rare Dis Res 8, 275-278.
Gastaldi M, Mariotto S, Giannoccaro MP, Iorio R, Zoccarato M, Nosadini M, Benedetti L, Casagrande S, Di Filippo M, Valeriani M, Ricci S, Bova S, Arbasino C, Mauri M, Versino M, Vigevano F, Papetti L, Romoli M, Lapucci C, Massa F, Sartori S, Zuliani L, Barilaro A, De Gaspari P, Spagni G, Evoli A, Liguori R, Ferrari S, Marchioni E, Giometto B, Massacesi L, Franciotta D(2020). Subgroup Comparison According to Clinical Phenotype and Serostatus in Autoimmune Encephalitis: A Multicenter Retrospective Study. Eur J Neurol. 27(4):633-643.
Mariottini A, Filippini S, Innocenti C, Forci B, Mechi C, Barilaro A, Fani A, Carlucci G, Saccardi R, Massacesi L, Repice AM, 2020. Impact of autologous haematopoietic stem cell transplantation on disability and brain atrophy in secondary progressive multiple sclerosis Mult Scler 2020 Feb 3;
Berardelli A, Silani V, Barone P, Calabresi P, Girlanda P, Lopiano L, Massacesi L, Monaco S, Onofrj M, Tassorelli C, Tedeschi G. (2020). Neurology and the COVID-19 emergency. Neurol Sci. 41:1343-1344
Piccini B, M, Amato MP, Bartalini S, Falcini M, Giannini M, Magnani E, Massacesi L, Repice AM, Vascotto M, Grosso S.. (2020). Association of celiac disease in patients with multiple sclerosis in Tuscany.Rev Esp Enferm Dig. 112:474-476.
Amoriello R, Greiff V, Aldinucci A, Bonechi E, Carnasciali A, Peruzzi B, Repice AM, Mariottini A, Saccardi R, Mazzanti B, Massacesi L, Ballerini C. (2020).The TCR Repertoire Reconstitution in Multiple Sclerosis: Comparing One-Shot and Continuous Immunosuppressive Therapies. Front Immunol. 11:559.
Steingo B, Al Malik Y, Bass AD, Berkovich R, Carraro M, Fernández Ó, Ionete C, Massacesi L, Meuth SG, Mitsikostas DD, Pardo G, Simm RF, Traboulsee A, Choudhry Z, Daizadeh N, Compston DAS CAMMS223, CAMMS03409, and TOPAZ Investigators. (2020). Long-term efficacy and safety of alemtuzumab in patients with RRMS: 12-year follow-up of CAMMS223.J Neurol. Jun 24. E-pub.
Berardelli A, Silani V, Barone P, Calabresi P, Girlanda P, Lopiano L, Massacesi L, Monaco S, Onofrj M, Tassorelli C, Tedeschi G., 2020. Neurology and the COVID-19 emergency.Neurol Sci. 41:1343-1344.
Signori A, Boffa G, Bovis F, Mariottini A, Repice AM, Inglese M, Amato MP, Mancardi GL, Massacesi L, Saccardi R and Sormani MP (2021). Prevalence of disability improvement as a potential outcome for multiple sclerosis trials. Multiple Sclerosis J., 27:706-711.
Lepore V, Bosetti C, Santucci C, Iaffaldano P, Trojano M, Mosconi P and the Italian Multiple Sclerosis Register Centers Group, the Scientific Committee of Italian SM Register. (2021). Detection of disability worsening in relapsing-remitting multiple sclerosis patients: a real-world roving Expanded Disability Status Scale reference analysis from the Italian Multiple Sclerosis Register. Eur J Neurol., 28567-578
Pasca M, Forci B, Mariottini A, Mechi C, Barilaro A, Massacesi L, Repice AM. (2021). Sustained disease remission after discontinuation of disease-modifying treatments in relapsing-remitting multiple sclerosis. Mult. Scler. Rel. Dis. 47: 102591. Online ahead of print.
Boffa, Massacesi L. Inglese M, Mariottini A, Capobianco M, Moiola L, Amato MP, Cottone S, Gualandi F, De Gobbi M, Greco R, Scime R, Frau J, Zimatore GB, Bertolotto A, ComiG, Uccelli A, Signori A, Angelucci E, Innocenti C, Ciceri F, Repice AM, Sormani MP, R. Saccardi R, Mancardi GL and the Italian BMT-MS study group. (2021). Long-Term Clinical Outcomes of Hematopoietic Stem Cell Transplantation in Multiple Sclerosis. Neurology 22;96(8): e1215-e1226. doi: 10.1212/WNL.0000000000011461.
Amoriello R, Chernigovskaya M, Greiff V, Carnasciali A, Massacesi L, Barilaro A, Repice AM, Biagioli T, Aldinucci A, Muraro PA, Laplaud DA, Lossius A, Ballerini C (2021). TCR repertoire diversity in Multiple Sclerosis: High-dimensional bioinformatics analysis of sequences from brain, cerebrospinal fluid and peripheral blood.EBioMedicine. 2021 Jun; 68:103429. Epub 2021 Jun 11.
Baroncini D, Simone M, Iaffaldano P, Brescia Morra V, Lanzillo R, Filippi M, Romeo M, Patti F, Chisari CG, Cocco E, Fenu G, Salemi G, Ragonese P, Inglese M, Cellerino M, Margari L, Comi G, Zaffaroni M, Ghezzi A. (2021). Italian MS registry. Risk of Persistent Disability in Patients With Pediatric-Onset Multiple Sclerosis.JAMA Neurol. Jun 1;78(6):726-735.
Contento M, Bertaccini B, Biggi M, Magliani M, Failli Y, Rosati E, Massacesi L, Paganini M. (2021). Prediction of seizure recurrence risk following discontinuation of antiepileptic drugs.Epilepsia. 2021 July12.
Contento M, Bertaccini B, Biggi M, Magliani M, Failli Y, Rosati E, Massacesi L, Paganini M. (2021) Response: Brightening the crystal ball: A constructive reappraisal of the postwithdrawal seizure relapse prediction model.Epilepsia. 62(12):3148-3149.
Mariottini A, Marchi L, Innocenti C, Di Cristinzi M, Pasca M, Filippini S, Barilaro A, Mechi C, Fani A, Mazzanti B, Biagioli T, Materozzi F, Saccardi R, Massacesi L and Repice AM (2022) Intermediate-Intensity Autologous Hematopoietic Stem Cell Transplantation Reduces Serum Neurofilament Light Chains and Brain Atrophy in Aggressive Multiple Sclerosis. Front. Neurol. 13:820256.
Mariottini A, Bulgarini G, Forci B, Innocenti C, Mealli F, Mattei A and Massacesi L. (2022). Autologous hematopoietic stem cell transplantation vs low-dose immunosuppression in secondary-progressive multiple sclerosis. European Journal of Neurology, 29:1708-1718.
Mariottini A, Bertozzi A, Marchi L, Di Cristinzi M, Mechi C, Barilaro A, Massacesi L and Repice AM. (2022) Effect of disease-modifying treatments on antibody-mediated response to anti- COVID19 vaccination in people with multiple sclerosis. Journal of Neurology, 269(6):2840-2847.
Mariottini A, Forci B, Gualdani E, Romoli M, Repice AM, Barilaro A, Mechi C, Massacesi L and Francesconi P. (2022). Incidence of malignant neoplasms and mortality in people affected by multiple sclerosis in the epoch of disease-modifying treatments: a population-based study on Tuscan residents. Multiple Sclerosis and Related Disorders,60:103679.
Azzolini F, Farina A, Gastaldi M, Barilaro A, Scotti V, Falchetti G, Fainardi E, Moretti M, and Massacesi L. (2022). Leptomeningeal gadolinium enhancement in autoimmune GFAP-astrocytopathy. Neurology,98:720-722.
Mariottini A, Repice AM, Barilaro A and Massacesi L (2022). Anti-SARS-Cov2 vaccination at the time of the COVID-19 pandemic: suspected adverse events reporting is the milestone of post-marketing surveillance". Neurological Sciences, 43:4095-4097.
MariottiniA, Marchi L., Innocenti C, Di CristinziM, Pasca M, FilippiniS, Barilaro A, MechiC, FaniA, Mazzanti B, Biagioli T, MaterozziF, Saccardi R, Massacesi L, RepiceAM. 2022. Intermediate-Intensity Autologous Hematopoietic Stem Cell Transplantation Reduces Serum Neurofilament Light Chains and Brain Atrophy in Aggressive Multiple Sclerosis. Front Neurol 24:820256.
Antonio Farina, Silvia Falso, Sara Cornacchini, Gregorio Spagni, Gabriele Monte, Alice Mariottini, Luca Massacesi, Alessandro Barilaro, Amelia Evoli, Valentina Damato. 2022. Safety and tolerability of SARS-Cov-2 vaccination in patients with myasthenia gravis: A multicenter experience. Eur J Neurol. 29:2505-2510
Bergamaschi R, BeghiE, Bosetti C, …………., L Massacesi, Maria Trojano, Mario Alberto Battaglia, Marco Capobianco, Maura Pugliatti, Monica Ulivelli, Paola Mosconi, Claudio Gasperini, Francesco Patti, Maria Pia Amato, Roberto Bergamaschi, Giancarlo Comi. 2022. Do patients' and referral centers' characteristics influence multiple sclerosis phenotypes? Results from the Italian multiple sclerosis and related disorders register. Neurol Sci. 43:5459-5469.
Amoriello R, Rizzo R, Mariottini A, Bortolotti D, Gentili V, Bonechi E, Aldinucci A, Carnasciali A, Peruzzi B, Repice AM, Massacesi L, Fainardi E, Ballerini C. (2022) Investigating Serum sHLA-G Cooperation With MRI Activity and Disease-Modifying Treatment Outcome in Relapsing-Remitting Multiple Sclerosis.Front Neurol.13:872396.
Massacesi L, Mariottini A, Nicoletti F. 2022. Relevance of Pathogenetic Mechanisms to Clinical Effectiveness of B-Cell-Depleting Monoclonal Antibodies in Multiple Sclerosis. J. Clin Med 1:4288-4293.
Cornacchini S, Farina A, Contento M, Berti V, Biggi M, Barilaro A, Massacesi L, Damato V, Rosati E. 2022. Long-term-video monitoring EEG and 18F-FDG-PET are useful tools to detect residual disease activity in anti-LGI1-Abs encephalitis: A case report. Front Neurol. 13: 949240.
Boffa G, Signori A, Massacesi L., Mariottini A, Sbragia E, Cottone S, Amato MP, Gasperini C, Moiola L, Meletti S, Repice AM, Brescia Morra V, Salemi G, Patti F, Filippi M, De Luca G, Lus G, Zaffaroni M, Sola P , Conte A, Nistri R, Aguglia U, Granella F, Galgani S, Caniatti LM, Lugaresi A, Romano S, Iaffaldano P, Cocco E, Saccardi R, Angelucci E, Troiano M, Luigi Mancardi GL, Maria Pia Sormani MP, and Inglese M.. (2023). Hematopoietic Stem Cell Transplantation In People With Active Secondary Progressive Multiple Sclerosis. Neurology, 100: e1109-e1122
Bertozzi A, Mariottini A, Marchi L, Cristinzi MD, Nistri R, Damato V, Mechi C, Barilaro A, Massacesi L, Repice AM. (2023). Safety and effectiveness of the booster dose of mRNA COVID-19 vaccines in people with multiple sclerosis: A monocentric experience. Mult Scler Relat Disord. 72:104582.
Mariottini A, Bulgarini G, Cornacchini S, Damato V, Saccardi R, Massacesi L. (2023). Hematopoietic Stem Cell Transplantation for the Treatment of Autoimmune Neurological Diseases: An Update. Bioengineering (Basel) 10(2):176.
Mosconi P, Guerra T, Paletta P, D'Ettorre A, Ponzio M, Battaglia MA, Amato MP, Bergamaschi R, Capobianco M, Comi G, Gasperini C, Patti F, Pugliatti M, Ulivelli M, Trojano M, Lepore V. and the Italian Multiple Sclerosis and Related Disorders Register Centres Group. 2023. Data monitoring roadmap. The experience of the Italian Multiple Sclerosis and Related Disorders Register. Neurol Sci. 44:4001-4011.
Beretta S., Cristillo V., Camera G., Morotti Colleoni C., Pellitteri G, Viti B, Bianchi E, Gipponi S, Grimoldi M, Valente M, Guttmann S, Cotelli MS, Palumbo P, Gelosa G, Meletti S, Schenone C, Ottaviani D, Filippi M, Zini A, Basilico P, Tancredi L, Cortelli P, Braga M, De Giuli V, Servidei S, Paolicelli D, Verde F, Caproni S, Pisani A, Lo Re V, Massacesi L, Valeria Roccatagliata DV, Manganotti P, ……….., Silani V, Tedeschi G, and Ferrarese C. (2023).Incidence and long-term functional outcome of neurological disorders in hospitalized COVID-19 patients infected with pre-Omicron variants. Neurology,101: e892-e903.
Farina A,Birzu C, Elsensohn MH, Picca A, Muñiz-Castrillo S, Vogrig A, Villagrán-García M, Ciano-Petersen NL, Massacesi L., Hervier B, Guégan S, Kramkimel N, Vano Y, Salem JE, Allenbach Y, Maisonobe T, Assaad S, Maureille A, Devic P, Weiss N, Pegat A, Maucort-Boulch D, Ricard D, Honnorat J, Psimaras D, Joubert B.. 2023. Neurological outcomes in immune checkpoint inhibitor-related neurotoxicity. Brain Communications 5: fcad169.
Mariottini A, Lotti A, Innocenti C, Repice AM, Nozzoli C, Boncompagni R, Fainardi E, Saccardi R and Massacesi L. (2023). Effect of the COVID-19 pandemic on disease activity in multiple sclerosis patients treated with hematopoietic stem cell transplantation.Eur J Neurol. 30:3362-3366.
Biggi M, Contento M, Magliani M, Giovannelli G, Barilaro A, Bessi V, Lombardo I, Massacesi L, Rosati E. (2023). Alice in wonderland syndrome "through the looking-glass" in a rare presentation of non-convulsive status epilepticus in cerebral venous sinus thrombosis and COVID-19. Cortex 167:218-222.
Lotti A, Barilaro A, Mariottini A, Vannozzi L, Piergentili M, Fainardi E and Massacesi L. (2023). Case report: 3D intracranial vessel wall MRI in Susac syndrome: potential relevance for diagnosis and therapeutic management. Front Neurol.14: 1201643.
Mariottini A, Nozzoli C, Carli I, Landi F, Gigli V, Repice AM, Ipponi A, Cecchi M, Boncompagni R, Saccardi R, Massacesi L.. 2024. Cost and effectiveness of autologous haematopoietic stem cell transplantation and high-efficacy disease-modifying therapies in relapsing-remitting multiple sclerosis. Neurol Sci. 2024 Jan 26. Online ahead of print.
Bellanca CM, Augello E, Mariottini A, Bonaventura G, La Cognata V, Di Benedetto G, Cantone AF, Attaguile G, Di Mauro R, Cantarella G, Massacesi L, Bernardini R.. (2024). Disease Modifying Strategies in Multiple Sclerosis: New Rays of Hope to Combat Disability? Curr Neuropharmacol. Jan 2024.
Iaffaldano P, Portaccio E, Lucisano G, Simone M, Manni A, Guerra T, Paolicelli D, Betti M, De Meo E, Pastò L, Razzolini L, Rocca MA, Ferrè L, Brescia Morra V, Patti F, Zaffaroni M, Gasperini C, De Luca G, Ferraro D, Granella F, Pozzilli C, Romano S, Gallo P, Bergamaschi R, Coniglio MG, Lus G, Vianello M, Banfi P, Lugaresi A, Totaro R, Spitaleri D, Cocco E, Di Palma F, Maimone D, Valentino P, Torri Clerici V, Protti A, Maniscalco GT, Salemi G, Pesci I, Aguglia U, Lepore V, Filippi M, Trojano M, Amato MP; (2024) Italian Multiple Sclerosis Register. (2024). Multiple Sclerosis Progression and Relapse Activity in Children. JAMA Neurol.;81:50-58.
Mealli F., Mattei A., Mariottini A and Massacesi L. (2024). Non-inferiority analysis of subcutaneous versus intravenous 300 mg monthly natalizumab administration: a post hoc analysis of the REFINE study. Mult Scler. Mar 13:13524585241238136.
Mariottini A, Barilaro A, Lotti A, Marra F and Massacesi L. (2024), Successful switch to ofatumumab after liver injury associated with ocrelizumab treatment in multiple sclerosis: a case report. Front Neurol.: 15:1363493
Marchi L, Mariottini A, Viti V, Bianchi A, Nozzoli C, Repice AM, Boncompagni R, Ginestroni A, Damato V, Barilaro A, Chiti S, Saccardi R, Fainardi E and Massacesi L. (2024). Leptomeningeal enhancement in multiple sclerosis: a focus on patients treated with hematopoietic stem cell transplantation. Front Neurol. 5;15:1373385. doi: 10.3389/fneur.2024.1373385.
Rinaldi C, Palumbo V., · Peyman N., · Viviani G, · Farina A. · Massacesi L. and Arba F. (2024). Adult‑onset of mild encephalitis/encephalopathy with reversible splenial lesion (MERS): case report and systematic review. Neurological Sciences. https/doi.org/10.1007/s10072-024-07627-0.
Mariottini A, Stack EH, Nair G, Nozzoli C, Wu T, Marchi L, Boncompagni R, Repice AM, Fainardi E, Pasquale FD, Carlesi E, Saccardi R, Jacobson S, Massacesi L. (2024). Spinal cord size as promising biomarker of disability outcomes after hematopoietic stem cell transplantation in multiple sclerosis. Mult Scler Relat. Disord. 88:105745.2024.
Marchi L, Mariottini A, Viti V, Bianchi A, Nozzoli C, Repice AM, Boncompagni R, Ginestroni A, Damato V, Barilaro A, Chiti S, Saccardi R, Fainardi E and Massacesi L.. (2024) Leptomeningeal enhancement in multiple sclerosis: a focus on patients treated with hematopoietic stem cell transplantation. Front Neurol. 5;15:1373385.
Mariottini A, Barilaro A, Lotti A, Marra F and Massacesi L.. (2024). Successful switch to ofatumumab after liver injury associated with ocrelizumab treatment in multiple sclerosis: a case report. Front Neurol. 2024 Feb 29;15: 1363493.
Mariottini A, Mealli F, Mattei A and Massacesi L. (2024). Comparative efficacy of subcutaneous versus intravenous natalizumab on annualized relapse rate: A post-hoc analysis of the REFINE study. Mult Scler Relat. Disord. 27; 91:105852.
Mariottini A,, Lotti A., Damato V, and Massacesi L. (2024). Challenges in Diagnosis of COVID-19 Pneumonia under Ocrelizumab and De-Risking Strategies in Multiple Sclerosis—The Elephant Is (Still) in the Room. Microorgan. 12(10): 10.3390/microorganisms12101941.
Ponzio M, Battaglia MA,Trojano M, Salivetto M, D'Ettorre A, Corrado D, Paletta P, Lepore V, Mosconi P, Comitato Scientifico del Registro Italiano Sclerosi Multipla e Patologie Correlate; Rete dei centri del Registro Italiano Sclerosi Multipla e Patologie Correlate. (2024) Epidemiol Prev 48::361-374.
Mariottini A, Boncompagni R, Cozzi D, Simonetti E, Repice AM, Damato V, Giordano M, Miele V, Nozzoli C, Massacesi L. (2024). Thymic hyperplasia after autologous hematopoietic stem cell transplantation in multiple sclerosis: a case series. Front Immunol. Nov 25; 15:1478777.
Fasano C, Bettiol A, Vastola M, Lotti A, Malandrino D, Mattioli I, Massacesi L, Emmi G, Barilaro A, Silvestri E. (2024). Effectiveness and safety of intravenous immunoglobulin for peripheral neuropathy in EGPA patients: a retrospective study. J Neurol. 272:13-16.
Frederiksen JL, Massacesi L, Nielsen HH, Rini A, Baldi E, Mirabella M, Antonella FFM, Lus G, Paolicelli D, Kant M, Salemi G, Aguglia U, Comi C, De Riz M, Barcella V, Flemmen HØ, Protti A, Farbu E, van Exel J, Torkildsen Ø. (2025). Effect of alemtuzumab on fatigue, quality of life, and patient/caregiver-reported outcomes in relapsing-remitting multiple sclerosis. A real-world evidence study. Mult Scler Relat Disord. 93:106214. doi: 10.1016/j.msard.2024.106214.
Giussani G, Bianchi E, Carlando E, DiFrancesco JC, Tabaee Damavandi P, Pasini F, Pederzoli G, Filipponi S, Gaiani A, Massacesi L, Rosati E, Giovannelli G, Cantisani TA, Cecconi M, Papetti R, Brioschi M, Aruta F, Agostoni EC, Paladin F, Dainese F, Longoni M, Yerma B, Gasparini S, Aguglia U, Ferlazzo E, Cantello R, Strigaro G, Maschio M, Benincasa D, La Neve A, Falcicchio G, Giordano A, Buttarelli L, Enia G, Leone M, Ferrarese C, Beghi E, Beretta S. (2025). Efficacy and tolerability of low versus standard daily doses of antiseizure medications in newly diagnosed focal epilepsy. A multicenter, randomized, single-blind, non-inferiority trial (STANDLOW).

Epilepsia Open. 2025 Feb 27. doi: 10.1002/epi4.70016. Online ahead of print.

Cornacchini S, Monaci A, Schiavolin M, Rosati E, Massacesi L, Berti V, Damato V. (2025). Brain [¹⁸F]FDG-PET as a marker of disease activity in a case of CASPR2 limbic encephalitis.Eur J Nucl Med Mol Imaging. Apr 7.
Bakchine S, Colosimo C, Emilsson E, Jónsdóttir SE, Massacesi L, Nonino F, Religa D, Richard E, Weydt P, Wolters FJ. Concerns about the approval of lecanemab for Alzheimer's disease. BMJ. 2025 Apr 22;389:r778.
Nonino F, Colosimo C, Massacesi L. (2025). Lecanemab and Alzheimer-Perusini's disease: between therapeutic hopes and regulatory challenges. Recenti Prog Med. 116:407-410.
Spagni G, Verza MU, Cornacchini S, Beretta F, Sun B, Lotti A, Falso S, Barilaro A, Massacesi L, Evoli A, Damato V. (2025Validation of the "Patient-Acceptable Symptom State" Question as Outcome Measure in AChR Myasthenia Gravis: A Multicentre, Prospective Study. Eur J Neurol.;32(6):e70262.
Mariottini A, Mazzeo AC, Simonetti E, Boncompagni E, Covicchio J, Barilaro A, Cutini I, Di Cristinzi M, Gozzini A, Mattei A, Mealli F, Repice AM, Nozzoli C and Massacesi L (2025). Autologous hematopoietic stem cell transplantation affects long-term progression independent of relapse activity in aggressive multiple sclerosis: a comparative matched study, JNNP, in press.

Book Chapters

Amaducci L., Massacesi L., Guarnieri B.M. (1983). Neurochemical aspects of multiple sclerosis. In "New trends of multiple sclerosis research", Cazzullo C. L., Caputo C.L., Ghezzi A. eds., pp. 125-130.
Amaducci L., Massacesi L., Guarnieri B.M., and Cambi F. (1984). Proteases, proteases inhibitors and diseases of the nervous system. In "Neuroimmunology", Behan P.O. and Spreafico F. eds., pp. 127-148. Raven Press (New York). Massacesi L. and Amaducci L. (1986). Selective immunosuppression in multiple sclerosis, in "Virology and immunology in multiple sclerosis", Cazzullo C.L., Caputo D., Ghezzi A., Zaffaroni M. editors, pp. 147-152. Springer-Verlag (Berlin).
Massacesi L., Abbamondi A.L., Castigli E., Sarlo F. and Amaducci L.(1987). Encefalomielite allergica sperimentale e acido retinoico. In "La neuroimmunologia clinica oggi", Annunziata P. and Guazzi G. eds.: 47-56, Piccin (Padova).
Massacesi L., Abbamondi A.L., Castigli E. and Amaducci L. (1988). Immunosuppression in experimental allergic encephalomyelitis. In "A multidisciplinary approach to myelin diseases", Serlupi Crescenzi G. ed. Plenum Press (New York) pp. 251-258.
Massacesi L., Abbamondi A.L., Castigli E., Sarlo F. and Amaducci L. (1988). Immunohistochemical study of the suppressive effect of retinoic acid (RA) on experimental allergic encephalomyelitis. In "Trends in European multiple sclerosis research", Confavreux C., Aimard G. and Devic M. eds. Excerpta Medica (Amsterdam), pp. 147-152.
Massacesi L., Abbamondi A.L., Sarlo S., Castigli E., Olivotto J., Vergelli M. and Amaducci L. (1989). Role of astroglial cells in experimental allergic encephalomyelitis. In “Trends in neuroimmunology”, Marrosu M.G., Cianchetti C. and Tavolato B. eds., Plenum Press (New York), pp. 97-102.
Massacesi L., Sarlo F., Abbamondi A.L., Castigli E., Olivotto J., Vergelli M., Raimondi L., Medica A. and Amaducci L. (1989). Immunosuppressive activity of Retinoic Acid (RA). In “Multiple Sclerosis Research”, M.A. Battaglia ed., Elsevier Science Publishers B.V., pp. 215-224. advances in multiple sclerosis therapy”, R.E. Gonsette, P. Delmotte, eds., Elsevier Science Publishers B.V., pp. 377-378.
Massacesi L., Sarlo F., Castigli E., Olivotto J., Vergelli M., Abbamondi A.L. and Amaducci L. (1989). Effects of retinoic acid on passive transfer EAE. In “Recent advances in multiple sclerosis therapy”, R.E. Gonsette, P. Delmotte, eds., Elsevier Science Publishers B.V., pp. 195-198.
Vergelli M., Sorrentino G. and Massacesi L. (1993). Malattie degenerative. In “Neuroimmunologia Clinica”, Bruno Tavolato ed. Il Pensiero Scientifico ed. (Roma), pp. 213-228.
Massacesi L., Amato M.P. and Amaducci L. (1994). Immunosuppression in Multiple Sclerosis: state of the art and future perspectives. In "A multidisciplinary approach to myelin diseases. II", S. Salvati ed. Plenum Press (New York), pp. 255-259.
Fonda C., Amato M.P., Massacesi L., Falcini M. Bartolozzi L. and Amaducci L. (1995). Confronto fra RM dopo somministrazione di gadolinio, senza e dopo applicazione del “trasferimento di magnetizzazione” nella sclerosi multipla. In “Neuroradiologia”, L.Bozzao editor, Centauro (Udine), pp.273-280.
Massacesi L. (1996). L’encefalomielite autoimmune sperimentale. In “Neurobiologia e Neuroimmunologia Clinica”, a cura di Federico A. e Annunziata P. CIC edizioni Internazionali (Roma), pp 85-93.
Mazzanti B., Traggiai E., Hemmer B., Martin R., Massacesi L., Vergelli M. (1999). The affinity spectrum of myelin basic protein reactive T cells. In “Advances in the immunopathogenesis of multiple sclerosis”. Gambi D., Muraro P.A.and Lugaresi A. eds. Sprinter (Milano, Italy), pp 3-10.
Vergelli M., Massacesi L., McFarland H. (2000). Immunopathogenesis of Multiple Sclerosis In “T cell autoimmunity in Multiple Sclerosis”. M. Londei ed., Landes Bioscience (Georgetown, Texas, USA), pp.133-148.
Massacesi L. (2000). Patogenesi della sclerosi multipla: meccanismo di cronicizzazione delle lesioni infiammatorie. In “Aspetti Immunologici e Terapeutici della Sclerosi Multipla” - C. Fieschi ed., UTET Periodici Scientifici (Milano), pp. 2-6.
Papini AM, Nardi, E, Mazzucco S, Mazzanti B, Traggia E, Ballerini C, Kalbacher H, Beck H, Chelli M, Ginanneschi M, Massacesi L, Vergelli M (2002). Lipophilic modifications of peptide epitopes: T-cell response and susceptibility to peptidases. In Peptides for the New Millennium, Fields G, James P.Tam, Barany G, Eds: 697-699.
Mancardi GL, Murialdo A, Saccardi R, Pagliai F, Gualandi F, Marmont A, Inglese M, Bruzzi P, Sormiani MP, Filippi, M., Marrosu M.G., Meucci G., Massacesi L, Bertolotto A, Lugaresi A., Morelli E., Filippi M e l’ Italian GITMO-NEURO Intergroup sul Trapiantato Autologo di cellule staminali ematopoietiche nella sclerosi multipla (2005). Il trapianto autologo di midollo osseo Intensa immunosoppressione seguita da trapianto autologo di cellule staminali in pazienti con forma grave di SM: dati clinici e RM. In L’interferone beta ed altre possibilità terapeutiche. L Durelli Ed., Excerpta Medica Elsevier (Milano), pp 97-106.
G.L. Mancardi, R. Saccardi, A. Murialdo, F. Pagliai, F. Gualandi, A. Marmont, M. Inglese, P. Bruzzi, M.P. Sormani, M.G. Marrosu, G. Meucci, L. Massacesi, A. Bertolotto, A. Lugaresi, E. Merelli, M. Filippi (2004) Intense Immunosuppression Followed by Autologous Stem Cell Transplantation in Severe Multiple Sclerosis Cases. In Stem Cell Therapy for Autoimmune Diseases, R. Burt ed., CRC Press, Boca Raton.

Other extended papers

Amaducci L. e Massacesi L.(1981). Modificazioni neurochimiche e prospettive di farmacologia sperimentale e clinica nella sclerosi multipla. Atti del XXII° congresso della Società Italiana di Neurologia: 197-206.
Cambi F., Massacesi L. and Amaducci L. (1982). La sclerosi multipla malattia degli anticorpi senza senso. Aggiornamento del Medico 1 (5): 39-45.
Amato M.P., Massacesi L. and Amaducci L. (1996). Clinical outcome measurements in Multiple Sclerosis trials. MS Forum. Int. MS Journal. 3(1) : 19-27.
Massacesi L. (2000). Correlati biologici e di laboratorio della patologia neuroimmune. In Atti del Convegno “Impiego delle Immunoglobuline E.V. in neurologia: attualità e prospettive”.
Massacesi L. and Vergelli M (2001). Experimental autoimmune encephalomyelitis as a model of multiple sclerosis.
Massacesi L. Ed. (2013). Percorsi assistenziali del paziente con Sclerosi Multipla. Maya Idee (Verona).
Massacesi L (2013). Ruolo delle Agenzie regolatorie nel percorso autorizzativo dei farmaci neurologici in Europa. Sclerosi Multipla news 4 (14): 4-7.
8. Mechi C., Repice A., Di Gioia M., Magnani E., Vuolo L., Bandini G., Massacesi L. (2014). Fingolimod therapy in a patient with idiopathic thrombocitopenic purpura. About Medicine 11: 23-25.
9. Sclerosi Multipla e gender medicine: position paper to practice (2015). Amato MP, Iudice A, Massacesi L., Ulivelli M. eds. Maya Idee (Verona).

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"ll sottoscritto è a conoscenza che, ai sensi dell’art 26 della Legge 15/68, le dichiarazioni mendaci, la falsità negli atti e l’uso di atti falsi sono puniti ai sensi del codice penale e delle leggi speciali. Inoltre il/la sottoscritto/a autorizza al trattamento dei dati personali, secondo quanto previsto dal D.L. 196/03 e dal nuovo regolamento generale sulla protezione dei dati n. 679/2016 e successive modifiche o integrazioni"

Florence, 18 Luglio 2025

Luca Massacesi

Luca MASSACESI

Pubblicazioni

Legenda

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Articolo su libro |

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Tesi di Dottorato

Mazzeo, Anna Chiara; Calabresi, Laura; Damato, Valentina; Spagni, Gregorio; Massacesi, Luca; Mariottini, Alice (2025). CD20+ T Cells in Multiple Sclerosis: From Pathogenesis to Treatment-Induced Depletion. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 26, pp. 0-0, ISSN:1422-0067 DOI

Mariottini, Alice; Nozzoli, Chiara; Carli, Ilaria; Landi, Filippo; Gigli, Valentina; Repice, Anna Maria; Ipponi, Alessandra; Cecchi, Michele; Boncompagni, Riccardo; Saccardi, Riccardo; Massacesi, Luca (2024). Cost and effectiveness of autologous haematopoietic stem cell transplantation and high-efficacy disease-modifying therapies in relapsing–remitting multiple sclerosis. NEUROLOGICAL SCIENCES, vol. 45, pp. 3379-3387, ISSN:1590-1874 DOI Accesso ONLINE all'editore

Chiara Lenzetti, Gianni Virgili, Luca Massacesi, Fabrizio Giansanti, Ilaria Biagini, Daniela Bacherini (2024). HIGH RESOLUTION IMAGING TECHNIQUES OF THE RETINA AND OPTIC NERVE FOR THE ANALYSIS OF MICROSTRUCTURAL AND VASCULAR CHANGES IN MULTIPLE SCLEROSIS. (Tutor: Gianni Virgili, Luca Massacesi)

Mealli, Fabrizia; Mattei, Alessandra; Mariottini, Alice; Massacesi, Luca (2024). Non-inferiority analysis of subcutaneous versus intravenous 300 mg monthly natalizumab administration: A post hoc analysis of the REFINE study. MULTIPLE SCLEROSIS, vol. 30, pp. 1077-1080, ISSN:1477-0970 DOI

Mariottini, Alice; Stack, Emily H.; Nair, Govind; Nozzoli, Chiara; Wu, Tianxia; Marchi, Leonardo; Boncompagni, Riccardo; Repice, Anna Maria; Fainardi, Enrico; Pasquale, Francesca Di; Carlesi, Edoardo; Saccardi, Riccardo; Jacobson, Steven; Massacesi, Luca (2024). Spinal cord size as promising biomarker of disability outcomes after hematopoietic stem cell transplantation in multiple sclerosis. MULTIPLE SCLEROSIS AND RELATED DISORDERS, vol. 88, pp. 105745-105753, ISSN:2211-0348 DOI

Marchi, Leonardo; Mariottini, Alice; Viti, Vittorio; Bianchi, Andrea; Nozzoli, Chiara; Repice, Anna Maria; Boncompagni, Riccardo; Ginestroni, Andrea; Damato, Valentina; Barilaro, Alessandro; Chiti, Stefano; Saccardi, Riccardo; Fainardi, Enrico; Massacesi, Luca (2024). Leptomeningeal enhancement in multiple sclerosis: a focus on patients treated with hematopoietic stem cell transplantation. FRONTIERS IN NEUROLOGY, vol. 15, pp. 1373385-1373393, ISSN:1664-2295 DOI

M. Contento, B. Bertaccini, M. Biggi, M. Magliani, Y. Failli, M. Paganini, E Rosati, L. Massacesi (2024). Seizure recurrence risk after discontinuation of anti-seizure medications: prognostic factors and development of a new predictive scale. (Tutor: Luca Massacesi, Eleonora Rosati)

Alessandro Sodero, Giulia Domna Scrima, Costanza Rapillo, Laura Tudisco, Ivano Lombardo, Giorgio Busto, Enrico Fainardi, Maria Giulia Maccaglia, Carola Lipani, Alessandra Murri, Tiziana Biagioli, Alessandra Fanelli, Betti Giusti, Anna Maria Gori, Leonardo Tenori, Emilia Conti, Letizia Anna Allegra Mascaro, Amalia Ferrara, Benedetta Piccardi, Vanessa Palumbo, Giovanni Pracucci, Niccolo Salvini, James Garrard, Davide Carone, James Kennedy, Cristina Sarti, Luca Massacesi. (2024). Integrating novel neuroimaging measurements and circulating biomarkers for the prediction of secondary injury following stroke. the NIMBLE study.. (Tutor: Dr.ssa Cristina Sarti, Prof Luca Massacesi)

Fasano C, Bettiol A, Vastola M, Lotti A, Malandrino D, Mattioli I, Massacesi L, Barilaro A, Silvestri E (2024). Effectiveness and safety of intravenous immunoglobulin for peripheral neuropathy in EGPA patients: a retrospective study. JOURNAL OF NEUROLOGY, vol. Volume 272, pp. 12731-12734, ISSN:0340-5354 DOI

Mariottini, Alice; Boncompagni, Riccardo; Cozzi, Diletta; Simonetti, Edoardo; Repice, Anna Maria; Damato, Valentina; Giordano, Mirella; Miele, Vittorio; Nozzoli, Chiara; Massacesi, Luca (2024). Thymic hyperplasia after autologous hematopoietic stem cell transplantation in multiple sclerosis: a case series. FRONTIERS IN IMMUNOLOGY, vol. 15, pp. 0-0, ISSN:1664-3224 DOI

Mariottini, Alice; Mealli, Fabrizia; Mattei, Alessandra; Massacesi, Luca (2024). Comparative efficacy of subcutaneous versus intravenous natalizumab on annualized relapse rate: a post-hoc analysis of the REFINE study. MULTIPLE SCLEROSIS AND RELATED DISORDERS, vol. 91, pp. 0-0, ISSN:2211-0348 DOI

Giovanna Carlucci, Adele Ratti, Anna Maria Repice, Maria Di Cristinzi, Luca Massacesi. (2024). Idiopathic Normal Pressure Hydrocephalus: multiparametric study of a cohort of patients undergoing cerebrospinal fluid tap test.. NEUROLOGICAL SCIENCES, vol. 45 (Suppl 1), pp. 145-145, ISSN:1590-1874 DOI Accesso ONLINE all'editore

Mariottini, Alice; Lotti, Antonio; Damato, Valentina; Massacesi, Luca (2024). Challenges in Diagnosis of COVID-19 Pneumonia under Ocrelizumab and De-Risking Strategies in Multiple Sclerosis—The Elephant Is (Still) in the Room. MICROORGANISMS, vol. 12, pp. 0-0, ISSN:2076-2607 DOI

Carla Fasano, Giovanna Carlucci, Maria Di Cristinzi, Anna Maria Repice, Alessandro Barilaro, Luca Massacesi. (2024). Headache and cerebrospinal fluid dynamics: spontaneous CSF rhinorrhea in a patient with history of idiopathic intracranial hypertension.. NEUROLOGICAL SCIENCES, vol. 45 (Suppl 1), pp. 222-222, ISSN:1590-1874 DOI Accesso ONLINE all'editore

Bellanca, Carlo Maria Maria; Augello, Egle; Mariottini, Alice; Bonaventura, Gabriele; Cognata, Valentina La; Benedetto, Giulia Di; Cantone, Anna Flavia; Attaguile, Giuseppe; Mauro, Rosaria Di; Cantarella, Giuseppina; Massacesi, Luca; Bernardini, Renato (2024). Disease Modifying Strategies in Multiple Sclerosis: New Rays of Hope to Combat Disability?. CURRENT NEUROPHARMACOLOGY, vol. 22, pp. 1286-1326, ISSN:1570-159X DOI

Simone Valente, Elena Capacci, Elisabetta Cecconi, Alessandro Barilaro, Ginevra Giovannelli, Alice Mariottini, Eleonora Rosati, Claudia Mechi, Luca Massacesi, Giovanna Carlucci. (2024). Acute unilateral sixth cranial nerve palsy and headache as initial manifestations of carcinomatous meningitis.. NEUROLOGICAL SCIENCES, vol. 45 (Suppl 1), pp. 247-247, ISSN:1590-1874 DOI Accesso ONLINE all'editore

Mariottini, Alice; Barilaro, Alessandro; Lotti, Antonio; Marra, Fabio; Massacesi, Luca (2024). Successful switch to ofatumumab after liver injury associated with ocrelizumab treatment in multiple sclerosis: a case report. FRONTIERS IN NEUROLOGY, vol. 15, pp. 0-0, ISSN:1664-2295 DOI

Alice Mariottini, Antonio Lotti, Chiara Innocenti, Anna Maria Repice , Chiara Nozzoli , Riccardo Boncompagni , Enrico Fainardi , Riccardo Saccardi, Luca Massacesi (2023). Effect of the COVID-19 pandemic on disease activity in multiple sclerosis patients treated with hematopoietic stem cell transplantation. EUROPEAN JOURNAL OF NEUROLOGY, vol. 30, pp. 3362-3366, ISSN:1351-5101 DOI Accesso ONLINE all'editore

Boffa, Giacomo; Signori, Alessio; Massacesi, Luca; Mariottini, Alice; Sbragia, Elvira; Cottone, Salvatore; Amato, Maria Pia; Gasperini, Claudio; Moiola, Lucia; Meletti, Stefano; Repice, Anna Maria; Morra, Vincenzo Brescia; Salemi, Giuseppe; Patti, Francesco; Filippi, Massimo; De Luca, Giovanna; Lus, Giacomo; Zaffaroni, Mauro; Sola, Patrizia; Conte, Antonella; Nistri, Riccardo; Aguglia, Umberto; Granella, Franco; Galgani, Simonetta; Caniatti, Luisa Maria; Lugaresi, Alessandra; Romano, Silvia; Iaffaldano, Pietro; Cocco, Eleonora; Saccardi, Riccardo; Angelucci, Emanuele; Trojano, Maria; Mancardi, Giovanni Luigi; Sormani, Maria Pia; Inglese, Matilde (2023). Hematopoietic Stem Cell Transplantation in People With Active Secondary Progressive Multiple Sclerosis. NEUROLOGY, vol. 100, pp. E1109-E1122, ISSN:0028-3878 DOI

Mariottini, Alice; Bulgarini, Giovanni; Cornacchini, Sara; Damato, Valentina; Saccardi, Riccardo; Massacesi, Luca (2023). Hematopoietic Stem Cell Transplantation for the Treatment of Autoimmune Neurological Diseases: An Update. BIOENGINEERING, vol. 10, pp. 0-0, ISSN:2306-5354 DOI

Beretta, Simone; Cristillo, Viviana; Camera, Giorgia; Morotti Colleoni, Carlo; Pellitteri, Gaia; Viti, Beatrice; Bianchi, Elisa; Gipponi, Stefano; Grimoldi, Maria; Valente, Mariarosaria; Guttmann, Susanna; Cotelli, Maria Sofia; Palumbo, Pasquale; Gelosa, Giorgio; Meletti, Stefano; Schenone, Cristina; Ottaviani, Donatella; Filippi, Massimo; Zini, Andrea; Basilico, Paola; Tancredi, Lucia; Cortelli, Pietro; Braga, Massimiliano; De Giuli, Valeria; Servidei, Serenella; Paolicelli, Damiano; Verde, Federico; Caproni, Stefano; Pisani, Antonio; Lo Re, Vincenzina; Massacesi, Luca; Roccatagliata, Daria Valeria; Manganotti, Paolo; Spitaleri, Daniele; Formenti, Anna; Piccoli, Marta; Marino, Silvia; Polverino, Paola; Aguglia, Umberto; Ornello, Raffaele; Perego, Elisabetta; Siciliano, Gabriele; Merlo, Paola; Capobianco, Marco; Pantoni, Leonardo; Lugaresi, Alessandra; Angelocola, Stefania; De Rosa, Anna; Sessa, Maria; Beghi, Ettore; Agostoni, Elio Clemente; Monaco, Salvatore; Padovani, Alessandro; Priori, Alberto; Silani, Vincenzo; Tedeschi, Gioacchino; Ferrarese, Carlo; Collaborators:; Andrea Pilotto, Stefano Cotti Piccinelli, Susanna Lazzari, Giulia Negro, Giulia Sofia Cereda, Roberto Infante, Ginevra Giovannelli, Claudia Cutellè, Lorenzo Tinti, Susanna Diamanti, Gaia Fanella, Nicola Rifino, Lucio Tremolizzo, Giovanni Ermanis, Fedra Kuris, Roberto Sartor, Francesco Bax, Gian Luigi Gigli, Edoardo Barvas, Mirco Volpini, Roberto Frusciante, Mariaeva Bernardi, Marinella Turla, Raffaella Valenti, Emanuele Bartolini, Lorenzo Kiferle, Silvia Pradella, Alessandro Innocenti, Ludovico Ciolli, Niccolò Orlandi, Gabriele Vandelli, Marco Mazzoli, Luana Benedetti, Matteo Pardini, Stefano Grisanti, Erica Biassoni, Corrado Cabona, Angelo Schenone, Federica Boso, Federica Agosta, Mario Orrico, Luisa Roveri, Giacomo Sferruzza, Mauro Gentile, Laura Piccolo, Elena Merli, Andrea Salmaggi, Tommaso Bocci, Roberta Ferrucci, Michelangelo Dini, Maria Guarino, Marianna Nicodemo, Sandro Beretta, Alessia Giossi, Chiara Campana, Bruno Censori, Guido Primiano, Maria Troiano, Luca Bollo, Narghes Calcagno, Francesca Trogu, Claudia Morelli, Carlo Colosimo, Chiara Di Schino, Franco Costantini, Giuseppe Cosentino, Enrico Marchioni, Federica Avorio, Giovanna Russelli, Giovanna Panarello, Giovanna Carlucci, Federica Azzolini, Antonio Lotti, Alfonso Ciccone, Giovanni Furlanis, Bruno Giometto, Giulia Bellavita, Scarano Valentina, Lorenzo Lorusso, Maria Concetta Altavista, Amelia Brigandì, Chiara Sorbera, Lucia Gatto, Simona Sacco, Raffaella Clerici, Erika Schirinzi, Enrica Bonanni, Elena Merico, Natascia Beretta, Giuseppe Gallo, Chiara Sciolla, Antonio Bertolotto, Simone Pomati, Federico Masserini, Federico Camilli, Ivan Panzera, Patrizio Cardinali, Maria Cristina Acciarri, Giovanna De Michele, Sandra Perillo, Gianluigi Rosalio Palmieri, Nunzia Cuomo, Augusta Giglio (2023). Incidence and Long-term Functional Outcome of Neurologic Disorders in Hospitalized Patients With COVID-19 Infected With Pre-Omicron Variants. NEUROLOGY, vol. 101, pp. e892-e903, ISSN:0028-3878 DOI

A. Mazzeo, M. Di Cristinzi, R. Nistri, A. Bertozzi, A. Barilaro, G. Carlucci, A. Mariottini, C. Mechi, L. Massacesi, T. Biagioli, A. Repice. (2023). K index improves MS diagnosis and supports the differential diagnosis between MS and MS-like syndromes.. EUROPEAN JOURNAL OF NEUROLOGY, vol. 30, pp. 633-633, ISSN:1351-5101 DOI Accesso ONLINE all'editore

Biggi, M.; Contento, M.; Magliani, M.; Giovannelli, G.; Barilaro, A.; Bessi, V.; Lombardo, I.; Massacesi, L.; Rosati, E. (2023). Alice in wonderland syndrome “through the looking-glass” in a rare presentation of non-convulsive status epilepticus in cerebral venous sinus thrombosis and COVID-19. CORTEX, vol. 167, pp. 218-222, ISSN:0010-9452 DOI

Carlo Tanzarella, Matteo Magliani, Ginevra Giovannelli, Orlando Malanga, Edoardo Fronzoni, Giulio Pastorelli, Valentina Berti, Giovanna Carlucci, Luca Massacesi, Eleonora Rosati. (2023). Amyloid Angiopathy related inflammation and paroxysmal events refractory to anti-seizure therapy: amyloid spells or seizures?. NEUROLOGICAL SCIENCES, vol. 44 (Suppl 2), pp. 201-202, ISSN:1590-1874 DOI

Bertozzi, Andrea; Mariottini, Alice; Marchi, Leonardo; Cristinzi, Maria Di; Nistri, Riccardo; Damato, Valentina; Mechi, Claudia; Barilaro, Alessandro; Massacesi, Luca; Repice, Anna Maria (2023). Safety and effectiveness of the booster dose of mRNA COVID-19 vaccines in people with multiple sclerosis: A monocentric experience. MULTIPLE SCLEROSIS AND RELATED DISORDERS, vol. 72, pp. 0-0, ISSN:2211-0356 DOI

Lotti, Antonio; Barilaro, Alessandro; Mariottini, Alice; Vannozzi, Lorenzo; Piergentili, Marco; Fainardi, Enrico; Massacesi, Luca (2023). Case report: 3D intracranial vessel wall MRI in Susac syndrome: potential relevance for diagnosis and therapeutic management. FRONTIERS IN NEUROLOGY, vol. 14, pp. 0-0, ISSN:1664-2295 DOI

Alice Mariottini, Leonardo Marchi, Chiara Innocenti, Maria Di Cristinzi, Matteo Pasca, Stefano Filippini, Alessandro Barilaro, Claudia Mechi, Arianna Fani, Benedetta Mazzanti, Tiziana Biagioli, Francesca Materozzi, Riccardo Saccardi, Luca Massacesi, Anna Maria Repice (2022). Intermediate-Intensity Autologous Hematopoietic Stem Cell Transplantation Reduces Serum Neurofilament Light Chains and Brain Atrophy in Aggressive Multiple Sclerosis.. FRONTIERS IN NEUROLOGY, vol. 13, pp. 0-0, ISSN:1664-2295 DOI Accesso ONLINE all'editore

Bergamaschi R.; Beghi E.; Bosetti C.; Ponzio M.; Santucci C.; Lepore V.; Mosconi P.; Aguglia U.; Amato M.P.; Ancona A.L.; Ardito B.; Avolio C.; Balgera R.; Banfi P.; Barcella V.; Barone P.; Bellantonio P.; Berardinelli A.; Bergamaschi R.; Bertora P.; Bianchi M.; Bramanti P.; Morra V.B.; Brichetto G.; Brioschi A.M.; Buccafusca M.; Bucello S.; Busillo V.; Calchetti B.; Cantello R.; Capobianco M.; Capone F.; Capone L.; Cargnelutti D.; Carrozzi M.; Cartechini E.; Cavaletti G.; Cavalla P.; Celani M.G.; Clerici R.; Clerico M.; Cocco E.; Confalonieri P.; Coniglio M.G.; Conte A.; Corea F.; Cottone S.; Crociani P.; D'Andrea F.; Danni M.C.; De Luca G.; de Pascalis D.; De Riz M.; De Robertis F.; De Rosa G.; De Stefano N.; Corte M.D.; Di Sapio A.; Docimo R.; Falcini M.; Falcone N.; Fermi S.; Ferraro E.; Ferro M.T.; Fortunato M.; Foschi M.; Gajofatto A.; Gallo A.; Gallo P.; Gatto M.; Gazzola P.; Giordano A.; Granella F.; Grasso M.F.; Grasso M.G.; Grimaldi L.M.E.; Iaffaldano P.; Imperiale D.; Inglese M.; Iodice R.; Leva S.; Luezzi V.; Lugaresi A.; Lus G.; Maimone D.; Mancinelli L.; Maniscalco G.T.; Marfia G.A.; Marini B.; Marson A.; Mascoli N.; Massacesi L.; Melani F.; Merello M.; Meucci G.; Mirabella M.; Montepietra S.; Nasuelli D.; Nicolao P.; Passantino F.; Patti F.; Peresson M.; Pesci I.; Piantadosi C.; Piras M.L.; Pizzorno M.; Plewnia K.; Pozzilli C.; Protti A.; Quatrale R.; Realmuto S.; Ribizzi G.; Rinalduzzi S.; Rini A.; Romano S.; Romeo M.; Ronzoni M.; Rossi P.; Rovaris M.; Salemi G.; Santangelo G.; Santangelo M.; Santuccio G.; Sarchielli P.; Sinisi L.; Sola P.; Solaro C.; Spitaleri D.; Strumia S.; Tassinari T.; Tonietti S.; Tortorella C.; Totaro R.; Tozzo A.; Trivelli G.; Ulivelli M.; Valentino P.; Venturi S.; Vianello M.; Zaffaroni M.; Zarbo R.; Trojano M.; Battaglia M.A.; Capobianco M.; Pugliatti M.; Ulivelli M.; Mosconi P.; Gasperini C.; Patti F.; Amato M.P.; Comi G. (2022). Do patients’ and referral centers’ characteristics influence multiple sclerosis phenotypes? Results from the Italian multiple sclerosis and related disorders register. NEUROLOGICAL SCIENCES, vol. 43, pp. 5459-5469, ISSN:1590-1874 DOI

Antonio Farina; Silvia Falso; Sara Cornacchini; Gregorio Spagni; Gabriele Monte; Alice Mariottini; Luca Massacesi; Alessandro Barilaro; Amelia Evoli; Valentina Damato (2022). Safety and tolerability of SARS-Cov-2 vaccination in patients with myasthenia gravis: A multicenter experience. EUROPEAN JOURNAL OF NEUROLOGY, vol. 29, pp. 2505-2510, ISSN:1351-5101 DOI

Cornacchini, S; Farina, A; Contento, M; Berti, V; Biggi, M; Barilaro, A; Massacesi, L; Damato, V; Rosati, E (2022). Long-term-video monitoring EEG and 18F-FDG-PET are useful tools to detect residual disease activity in anti-LGI1-Abs encephalitis: A case report. FRONTIERS IN NEUROLOGY, vol. 13, pp. 0-0, ISSN:1664-2295 DOI

Massacesi, Luca; Mariottini, Alice; Nicoletti, Ferdinando (2022). Relevance of Pathogenetic Mechanisms to Clinical Effectiveness of B-Cell-Depleting Monoclonal Antibodies in Multiple Sclerosis. JOURNAL OF CLINICAL MEDICINE, vol. 11, pp. 0-0, ISSN:2077-0383 DOI Accesso ONLINE all'editore

Amoriello R.; Rizzo R.; Mariottini A.; Bortolotti D.; Gentili V.; Bonechi E.; Aldinucci A.; Carnasciali A.; Peruzzi B.; Repice A.M.; Massacesi L.; Fainardi E.; Ballerini C. (2022). Investigating Serum sHLA-G Cooperation With MRI Activity and Disease-Modifying Treatment Outcome in Relapsing-Remitting Multiple Sclerosis. FRONTIERS IN NEUROLOGY, vol. 13, pp. 872396-872406, ISSN:1664-2295 DOI

Mariottini A, Repice AM, Barilaro A, Massacesi L (2022). Anti-SARS-Cov2 vaccination at the time of the COVID-19 pandemic: suspected adverse events reporting is the milestone of post-marketing surveillance. NEUROLOGICAL SCIENCES, vol. 43, pp. 4095-4097, ISSN:1590-3478 DOI

Federica Azzolini, Alice Mariottini, Anna Maria Repice, Giovanna Carlucci, Alessandro Barilaro, Benedetta Forci, Matteo Grammatico, Claudia Mechi, Enrico Fainardi, Luca Massacesi (2022). Low positive predictive value of Multiple Sclerosis diagnostic criteria in demyelinating syndromes with red flags of better explanation.. NEUROLOGICAL SCIENCES, vol. 43 (suppl), pp. 440-440, ISSN:1590-1874 DOI Accesso ONLINE all'editore

Mariottini Alice , Forci Benedetta , Gualdani Elisa, Romoli Monica, Repice Anna Maria, Barilaro Alessandro, Mechi Claudia, Massacesi Luca, Francesconi Paolo (2022). Incidence of malignant neoplasms and mortality in people affected by multiple sclerosis in the epoch of disease-modifying treatments: a population-based study on Tuscan residents. MULTIPLE SCLEROSIS AND RELATED DISORDERS, vol. 60, pp. 0-0, ISSN:2211-0348 DOI Accesso ONLINE all'editore

Azzolini F.; Farina A.; Gastaldi M.; Barilaro A.; Scotti V.; Falchetti G.; Fainardi E.; Moretti M.; Massacesi L. (2022). Leptomeningeal Gadolinium Enhancement in Autoimmune GFAP Astrocytopathy. NEUROLOGY, vol. 98, pp. 720-722, ISSN:1526-632X DOI

Mariottini, Alice; Bulgarini, Giovanni; Forci, Benedetta; Innocenti, Chiara; Mealli, Fabrizia; Mattei, Alessandra; Ceccarelli, Chiara; Repice, Anna Maria; Barilaro, Alessandro; Mechi, Claudia; Saccardi, Riccardo; Massacesi, Luca (2022). Autologous hematopoietic stem cell transplantation versus low-dose immunosuppression in secondary-progressive multiple sclerosis. EUROPEAN JOURNAL OF NEUROLOGY, vol. 29, pp. 1708-1718, ISSN:1351-5101 DOI

Mariottini A, Bertozzi A, Marchi L, Di Cristinzi M, Mechi C,Barilaro A,Massacesi L,Repice A. (2022). Effect of disease-modifying treatments on antibody-mediated response to anti- COVID19 vaccination in people with multiple sclerosis. JOURNAL OF NEUROLOGY, vol. 269, pp. 2840-2847, ISSN:0340-5354 DOI Accesso ONLINE all'editore

Antonio Lotti, Alice Mariottini, Alessandro Barilaro, Giovanna Carlucci, Lorenzo Vannozzi, Enrico Fainardi, Luca Massacesi. (2022). Magnetic Resonance intracranial Vessel Wall Imaging (VWI) in Susac Syndrome: potential relevance for diagnosis and therapeutic management.. NEUROLOGICAL SCIENCES, vol. 43 (Suppl 1), pp. 71-72, ISSN:1590-1874 DOI Accesso ONLINE all'editore

A Mariottini, C Innocenti, G Rastrelli, L Vignozzi, A Giachi, R Saccardi, L Massacesi, A Repice (2021). Impact of autologous haematopoietic stem cell transplantation on fertility in aggressive multiple sclerosis. EUROPEAN JOURNAL OF NEUROLOGY, vol. 28 supplement 1, pp. 384-384, ISSN:1351-5101 Accesso ONLINE all'editore

Contento, Margherita; Bertaccini, Bruno; Biggi, Martina; Magliani, Matteo; Failli, Ylenia; Rosati, Eleonora; Massacesi, Luca; Paganini, Marco (2021). Prediction of seizure recurrence risk following discontinuation of antiepileptic drugs. EPILEPSIA, pp. 2159-2170, ISSN:0013-9580 DOI Accesso ONLINE all'editore

Contento M.; Bertaccini B.; Biggi M.; Magliani M.; Failli Y.; Rosati E.; Massacesi L.; Paganini M. (2021). Response: Brightening the crystal ball: A constructive reappraisal of the postwithdrawal seizure relapse prediction model. EPILEPSIA, pp. 1-2, ISSN:0013-9580 DOI Accesso ONLINE all'editore

Mariottini, A; Farina, A; Innocenti, C; Romoli, M; Zilio, I; Azzolini, F; Repice, A; Saccardi, R; Carlucci, G; Massacesi, L (2021). Neuropsychological assessment in aggressive multiple sclerosis treated with stem cell transplantation. EUROPEAN JOURNAL OF NEUROLOGY, vol. 28, pp. 362-362, ISSN:1351-5101 Accesso ONLINE all'editore

Mariottini A.; Filippini S.; Innocenti C.; Forci B.; Mechi C.; Barilaro A.; Fani A.; Carlucci G.; Saccardi R.; Massacesi L.; Repice A.M. (2021). Impact of autologous haematopoietic stem cell transplantation on disability and brain atrophy in secondary progressive multiple sclerosis. MULTIPLE SCLEROSIS, vol. 27, pp. 61-70, ISSN:1352-4585 DOI Accesso ONLINE all'editore

E. Sbragia, A. Mariottini, M. Capobianco, S. Martire, L. Moiola, M.P. Amato, L. Massacesi, G. Mancardi, G. Boffa, M. Inglese (2021). COVID-19 in patients with aggressive MS treated with aHSCT: a multi-center study. MULTIPLE SCLEROSIS, vol. 27, pp. 0-0, ISSN:1352-4585 Accesso ONLINE all'editore

Boffa G, Massacesi L, Inglese M, Mariottini A, Capobianco M, Moiola L, Amato MP, Cottone S, Gualandi F, De Gobbi M, Greco R, Scime R, Frau J, Zimatore GB, Bertolotto A, Comi G, Uccelli A, Signori A, Angelucci E, Innocenti C, Ciceri F, Repice AM, Sormani MP, Saccardi R, Mancardi GL, and the Italian BMT-MS study group (2021). Long-Term Clinical Outcomes of Hematopoietic Stem Cell Transplantation in Multiple Sclerosis. NEUROLOGY, vol. 96, pp. E1215-E1226, ISSN:0028-3878 DOI

Cristina Tassorelli, Vincenzo Silani, Alessandro Padovani, Paolo Barone, Paolo Calabresi, Paolo Girlanda, Leopnardo Lopiano, Luca Massacesi, Salvatore Monaco, Marco Onofrj, Gioacchino Tedeschi, Alfredo Berardelli (2021). The contribution of the Italian residents in neurology to the COVID-19 crisis: admirable generosity but neurological training remains their priority. NEUROLOGICAL SCIENCES, vol. 42, pp. 4425-4431, ISSN:1590-3478 DOI Accesso ONLINE all'editore

Pasca M, Forci B, Mariottini A, Mechi C, Barilaro A, Massacesi L, Repice AM. (2021). Sustained disease remission after discontinuation of disease modifying treatments in relapsing-remitting multiple sclerosis.. MULTIPLE SCLEROSIS AND RELATED DISORDERS, vol. 47, pp. 0-0, ISSN:2211-0348 DOI

Antonio Farina, Alice Mariottini, Federica Azzolini, Claudia Mechi, Anna Maria Repice, Alessandro Barilaro, Luca Massacesi (2021). Clinical and paraclinical findings in a case series of MOGAD: Exploring the presence of perivenular brain white matter lesions. JOURNAL OF THE NEUROLOGICAL SCIENCES, vol. 429, pp. 0-0, ISSN:0022-510X DOI Accesso ONLINE all'editore

Piccini, Barbara; Ulivelli, Monica; Amato, Maria Pia; Bartalini, Sabina; Falcini, Mario; Giannini, Marta; Magnani, Eliana; Massacesi, Luca; Repice, Anna Maria; Vascotto, Marina; Grosso, Salvatore (2020). Association of celiac disease in patients with multiple sclerosis in Tuscany. REVISTA ESPAÑOLA DE ENFERMEDADES DIGESTIVAS, vol. 112, pp. 1-9, ISSN:1130-0108 DOI

Maggi P.; Absinta M.; Sati P.; Perrotta G.; Massacesi L.; Dachy B.; Pot C.; Meuli R.; Reich D.S.; Filippi M.; Pasquier R.D.; Theaudin M. (2020). The “central vein sign” in patients with diagnostic “red flags” for multiple sclerosis: A prospective multicenter 3T study. MULTIPLE SCLEROSIS, pp. 0-0, ISSN:1352-4585 DOI Accesso ONLINE all'editore

Amoriello, Roberta; Greiff, Victor; Aldinucci, Alessandra; Bonechi, Elena; Carnasciali, Alberto; Peruzzi, Benedetta; Repice, Anna Maria; Mariottini, Alice; Saccardi, Riccardo; Mazzanti, Benedetta; Massacesi, Luca; Ballerini, Clara (2020). The TCR Repertoire Reconstitution in Multiple Sclerosis: Comparing One-Shot and Continuous Immunosuppressive Therapies. FRONTIERS IN IMMUNOLOGY, vol. 11, pp. 1-19, ISSN:1664-3224 DOI Accesso ONLINE all'editore

Gastaldi M, Mariotto S, Giannoccaro MP, Iorio R, Zoccarato M, Nosadini M, Benedetti L, Casagrande S, Di Filippo M, Valeriani M, Ricci S, Bova S, Arbasino C, Mauri M, Versino M, Vigevano F, Papetti L, Romoli M, Lapucci C, Massa F, Sartori S,7, Zuliani L, Barilaro A, De Gaspari P, Spagni G, Evoli A, Liguori R, Ferrari S, Marchioni E, Giometto B, Massacesi L, Franciotta D. (2020). Subgroup Comparison According to Clinical Phenotype and Serostatus in Autoimmune Encephalitis: A Multicenter Retrospective Study. EUROPEAN JOURNAL OF NEUROLOGY, vol. 27, pp. 633-643, ISSN:1468-1331 DOI

Carlucci, G; Sodero, A; Buti, V; Failli, Y; Paganini, M; Massacesi, L (2020). Evaluation of cognitive and language side effects of topiramate in patients with epilepsy, and effectiveness of counseling and speech therapy interventions. EUROPEAN JOURNAL OF NEUROLOGY, vol. 27, pp. 591-591, ISSN:1351-5101 Accesso ONLINE all'editore

Signori A.; Boffa G.; Bovis F.; Mariottini A.; Repice A.; Inglese M.; Amato M.P.; Mancardi G.; Massacesi L.; Saccardi R.; Sormani M.P. (2020). Prevalence of disability improvement as a potential outcome for multiple sclerosis trials. MULTIPLE SCLEROSIS, pp. 1-6, ISSN:1352-4585 DOI

Innocenti, C; Di Gioia, M; Amato, MP; Ciccone, N; Cutini, I; Giannini, M; Gozzini, A; Guidi, S; Mariottini, A; Massacesi, L; Nozzoli, C; Repice, A; Maria, RG; Saccardi, R (2019). Management of viral reactivation in multiple sclerosis patients after autologous transplantation with BEAM/ATG conditioning regimen. BONE MARROW TRANSPLANTATION, vol. 54, pp. 174-175, ISSN:0268-3369

Mariottini, A; Filippini, S; Di Tullio, MG; Forci, B; Innocenti, C; Barilaro, A; Fani, A; Saccardi, R; Massacesi, L; Repice, AM (2019). Efficacy of autologous hematopoietic stem cell transplantation in secondary progressive Multiple sclerosis. EUROPEAN JOURNAL OF NEUROLOGY, vol. 26, pp. 106-106, ISSN:1351-5101

Coles, A; Berkovich, R; Carraro, M; Compston, DAS; Al Malik, Y; Fernandez, O; Ionete, C; Massacesi, L; Meuth, SG; Mitsikostas, D; Pardo, G; Simm, RF; Steingo, B; Choudhry, Z; Daizadeh, N; Traboulsee, A (2019). Long-term efficacy and safety of Alemtuzumab in patients with RRMS: 12-year follow-up of the CAMMS223 study. MULTIPLE SCLEROSIS, vol. 25, pp. 320-321, ISSN:1352-4585

Montalban, X; Barone, D; Broadley, S; Dive, D; Hupperts, RM; Lycke, J; Massacesi, L; Naismith, RT; Nakamura, K; Pandey, K; Schippling, S; Vermersch, P; Wiendl, H; Chung, L; Daizadeh, N; Afsar, S; Van Wijmeersch, B (2019). Alemtuzumab improves outcomes in RRMS patients who switched from SC IFNB-1a: 6-year follow-up of CARE-MS I Patients (TOPAZ Study). EUROPEAN JOURNAL OF NEUROLOGY, vol. 26, pp. 678-678, ISSN:1351-5101

Mechi, C; Mariottini, A; Pasca, M; Forci, B; Magnani, E; Barilaro, A; Repice, AM; Massacesi, L (2019). Comparative long term efficacy of beta interferons and azathioprine in relapsing-remitting Multiple sclerosis: single center retrospective 25 year evaluation. EUROPEAN JOURNAL OF NEUROLOGY, vol. 26, pp. 106-106, ISSN:1351-5101

Mata, S; Barilaro, A; Massacesi, L; Sorbi, S (2019). POLYNEUROPATHY ASSOCIATED WITH MONOCLONAL GAMMOPATHY: AN OBSERVATIONAL STUDY. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, vol. 24, pp. S31-S31, ISSN:1085-9489

Azzolini, F; Grammatico, M; Filippini, S; Carlucci, G; Repice, AM; Forci, B; Dallagiacoma, S; Busto, G; Fainardi, E; Massacesi, L (2019). MRI analysis of the "central vein sign" allows identification of a subset of relapsing remitting MS patients with brain pathology different from inflammatory demyelination. EUROPEAN JOURNAL OF NEUROLOGY, vol. 26, pp. 473-474, ISSN:1351-5101

Azzolini, F; Grammatico, M; Carlucci, G; Goanta, L; Dallagiacoma, S; Repice, AMR; Forci, B; Dipasquale, F; Marchi, L; Fainardi, E; Massacesi, L (2019). MS patients with low central vein sign frequency can be identified by FLAIR* MRi sequences. NEUROLOGY, vol. 92, pp. 0-0, ISSN:0028-3878

Azzolini, F; Grammatico, M; Carlucci, G; Goanta, L; Dallagiacoma, S; Forci, B; Barilaro, A; Repice, AM; Busto, G; Fainardi, E; Massacesi, L (2019). The Central Vein Sign identifies patients diagnosed with multiple sclerosis probably carrying different diseases and showing milder disease course. MULTIPLE SCLEROSIS, vol. 25, pp. 135-136, ISSN:1352-4585

Pasca M.; Picchioni A.; Mazzeo S.; Terenzi F.; Prestipino E.; Fratangelo R.; Repice A.M.; Carlucci G.; Massacesi L.; Barilaro A. (2019). A case of recurrent progressive multifocal leukoencephalopathy after human stem cell transplant, with detection of John Cunningham virus and human herpesvirus 6 on cerebrospinal fluid, treated with Mirtazapine, Olanzapine and Foscarnet. IRDR, vol. 8, pp. 275-278, ISSN:2186-3644 DOI Accesso ONLINE all'editore

Forci, B; Mariottini, A; Mechi, C; Magnani, E; Barilaro, A; Falcini, M; Palumbo, P; Massacesi, L; Repice, AM (2019). Evaluation of dimethyl fumarate efficacy and safety in patients with relapsing remitting multiple sclerosis switching from other treatments. EUROPEAN JOURNAL OF NEUROLOGY, vol. 26, pp. 490-490, ISSN:1351-5101

Gastaldi, M; Casagrande, S; Benedetti, L; Bova, S; Di Filippo, M; Evoli, A; Ferrari, S; Foiadelli, T; Giacomini, T; Iorio, R; Mancardi, M; Mariotto, S; Mauri, M; Massa, F; Nosadini, M; Papetti, L; Ricci, S; Sartori, S; Savasta, S; Valeriani, M; Zoccarato, M; Zuliani, L; Massacesi, L; Franciotta, D (2019). Clinico-serological features in autoimmune encephalitis: an Italian multicentre retrospective study. EUROPEAN JOURNAL OF NEUROLOGY, vol. 26, pp. 59-60, ISSN:1351-5101

Casagrande, S; Gastaldi, M; Barilaro, A; Biagioli, T; Paganini, M; Franciotta, D; Massacesi, L (2019). The spectrum of auto-immune encephalitis: Clinical characterisation and comparison between different syndromes defined by 2016 diagnostic criteria. EUROPEAN JOURNAL OF NEUROLOGY, vol. 26, pp. 705-705, ISSN:1351-5101

Trojano M, Bergamaschi R, Amato MP, Comi G, Ghezzi A, Lepore V, Marrosu MG, Mosconi P, Patti F, Ponzio M, Zaratin P, Battaglia MA; Italian Multiple Sclerosis Register Centers Group. Collaborators (138) Acquistapace D, Aguglia U, Amato MP, Annunziata P, Ardito B, Avolio C, Balgera R, Bandini F, Banfi P, Barone P, Bellantonio P, Bergamaschi R, Bertolotto A, Bertora P, Bombardi R, Bosco Zimatore G, Bossio RB, Bramanti P, Brescia Morra V, Brioschi AM, Bruzzone M, Buccafusca M, Busillo V, Caneve G, Caniatti LM, Capone L, Capone F, Cappellani A, Cargnelutti D, Cavaletti G, Cavalla P, Celani MG, Centonze D, Chiveri L, Clerici R, Clerico M, Cocco E, Comi G, Comi C, Coniglio MG, Cordera S, Corea F, Cortese A, Costantino G, Cottone S, Crociani P, D'Andrea F, Danni MC, De Luca G, de Pascalis D, De Robertis F, De Stefano N, Di Battista G, Di Napoli M, Falcini M, Fausto F, Ferrò MT, Florio C, Fortunato M, Frittelli C, Galgani S, Gallo P, Gatto M, Gazzola P, Geda C, Giordano A, Granella F, Grasso MG, Grimaldi LME, Imperiale D, Lo Russo L, Logullo FO, Lugaresi A, Lus G, Maccarrone G, Maimone D, Malagù S, Marconi R, Maritato P, Massacesi L, Mazzoni M, Meucci G, Mirabella M, Montepietra S, Nasuelli D, Neri W, Orefice G, Parodi S, Pasquali L, Passarella B, Patti F, Peresson M, Perla F, Pesci I, Piantadosi C, Piras ML, Pizio NR, Pozzilli C, Protti A, Pugliatti M, Quatrale R, Ragno M, Ragno M, Rezzonico M, Ribizzi G, Riva M, Ronzoni M, Rosso MG, Rottoli M, Rovaris M, Salemi G, Salvetti M, Santangelo M, Santangelo G, Santuccio G, Santuccio G, Sarchielli P, Scarpini E, Sechi GP, Severi S, Sinisi L, Sola P, Spitaleri D, Tassinari T, Tedeschi G, Tonietti S, Torri Clerici V, Totaro R, Traccis S, Trojano M, Turla M, Uccelli A, Ulivelli M, Valentino P, Valeriani M, Venturi S, Vianello M, Zaffaroni M. (2019). The Italian multiple sclerosis register.. NEUROLOGICAL SCIENCES, vol. 40, pp. 155-165, ISSN:1590-3478 DOI Accesso ONLINE all'editore

Mariottini A, Innocenti C, Forci B, Magnani E, Mechi C, Barilaro A, Nistri R, Fani A, Saccardi R, Massacesi L, Repice AM. (2019). Safety and efficacy of autologous hematopoietic stem cell transplantation following natalizumab discontinuation in aggressive Multiple Sclerosis. EUROPEAN JOURNAL OF NEUROLOGY, vol. 26, pp. 624-630, ISSN:1351-5101 DOI Accesso ONLINE all'editore

Pasca, M; Forci, B; Mechi, C; Mariottini, A; Barilaro, A; Massacesi, L; Repice, AM (2019). Clinical characteristics predicting relapses following disease modifying therapies discontinuation in multiple sclerosis: a monocentric cohort study. MULTIPLE SCLEROSIS, vol. 25, pp. 340-341, ISSN:1352-4585

Innocenti, C; Amato, MP; Barilaro, A; Bianchini, G; Capobianco, T; Calia, MA; Ceschini, R; Fani, A; Giannini, M; Gozzini, A; Guidi, S; Mariottini, A; Massacesi, L; Nozzoli, C; Repice, A; Rossolini, G; Saccardi, R (2018). Reconstitution of natural or vaccination-driven immunity after aHSCT in multiple sclerosis. BONE MARROW TRANSPLANTATION, vol. 53, pp. 210-210, ISSN:0268-3369

Pradella, S; Paganini, M; Barilaro, A; Casagrande, S; Biagioli, T; Franciotta, D; Massacesi, L (2018). Autoimmune epilepsy in drug resistent and in new onset refractory epilepsy. EUROPEAN JOURNAL OF NEUROLOGY, vol. 25, pp. 554-554, ISSN:1351-5101

Massacesi, L (2018). Challenges for modern MS therapy on back-ground of pathogenesis. EUROPEAN JOURNAL OF NEUROLOGY, vol. 25, pp. 12-12, ISSN:1351-5101

D'Amore, Angelica; Tessa, Alessandra; Casali, Carlo; Dotti, Maria Teresa; Filla, Alessandro; Silvestri, Gabriella; Antenora, Antonella; Astrea, Guja; Barghigiani, Melissa; Battini, Roberta; Battisti, Carla; Bruno, Irene; Cereda, Cristina; Dato, Clemente; Di Iorio, Giuseppe; Donadio, Vincenzo; Felicori, Monica; Fini, Nicola; Fiorillo, Chiara; Gallone, Salvatore; Gemignani, Federica; Gigli, Gian Luigi; Graziano, Claudio; Guerrini, Renzo; Gurrieri, Fiorella; Kariminejad, Ariana; Lieto, Maria; Marques LourenḈo, Charles; Malandrini, Alessandro; Mandich, Paola; Marcotulli, Christian; Mari, Francesco; Massacesi, Luca; Melone, Maria A B; Mignarri, Andrea; Milone, Roberta; Musumeci, Olimpia; Pegoraro, Elena; Perna, Alessia; Petrucci, Antonio; Pini, Antonella; Pochiero, Francesca; Pons, Maria Roser; Ricca, Ivana; Rossi, Salvatore; Seri, Marco; Stanzial, Franco; Tinelli, Francesca; Toscano, Antonio; Valente, Mariarosaria; Federico, Antonio; Rubegni, Anna; Santorelli, Filippo Maria (2018). Next Generation Molecular Diagnosis of Hereditary Spastic Paraplegias: An Italian Cross-Sectional Study. FRONTIERS IN NEUROLOGY, vol. 9, pp. 0-0, ISSN:1664-2295 DOI

Maggi, P; Zellini, F; Passeri, A; Barilaro, A; Massacesi, L (2018). Natural history of brain inflammatory lesions in multiple sclerosis: a FLAIR and T1w post contrast MRI volumetric analysis. EUROPEAN JOURNAL OF NEUROLOGY, vol. 25, pp. 345-345, ISSN:1351-5101

Van Wijmeersch, B; Barone, D; Broadley, S; Dive, D; Hupperts, RMM; Lycke, J; Massacesi, L; Montalban, X; Naismith, RT; Pandey, K; Schippling, S; Vermersch, P; Chung, L; Daizadeh, N; Rodriguez, CE; Nakamura, K; Wiendl, H (2018). Alemtuzumab outcomes over 6 years in RRMS patients who switched from SC IFNB-1a: follow-up of CARE-MS I patients (TOPAZ study). MULTIPLE SCLEROSIS, vol. 24, pp. 488-489, ISSN:1352-4585

Zamboni, P; Tesio, L; Galimberti, S; Massacesi, L; Salvi, F; D'Alessandro, R; Cenni, P; Galeotti, R; Papini, D; D'Amico, R; Simi, S; Valsecchi, Mg; Filippini, G; Brave Dreams Research Group, (2018). Efficacy and Safety of Extracranial Vein Angioplasty in Multiple Sclerosis: A Randomized Clinical Trial.. JAMA NEUROLOGY, vol. 75, pp. 35-43, ISSN:2168-6157 DOI Accesso ONLINE all'editore

Aldinucci, A; Rizzo, R; Bonechi, E; Fainardi, E; Bortolotti, D; Mariottini, A; Mechi, C; Repice, AM; Massacesi, L; Ballerini, C (2018). Soluble factor profile in Natalizumab treated MS patients: increased Th1 promoting factors and sHLAg. EUROPEAN JOURNAL OF NEUROLOGY, vol. 25, pp. 350-350, ISSN:1351-5101

Maria Pia, Amato ; Alfredsson, Lars; Aloisi, Francesca; Ascherio, Alberto; Baldin, Elisa; Bjørnevik, Kjetil; Comabella, Manuel; Correale, Jorge; Cortese, Marianna; Derfuss, Tobias; D’Hooghe, Marie; Ghezzi, Angelo; Gold, Julian; Hellwig, Kerstin; Hemmer, Bernhard; Koch-Henricksen, Nils; Gould, Annette Langer; Liblau, Roland; Linker, Ralf; Lolli, Francesco; Lucas, Robyn; Lünemann, Jan; Magyari, Melinda; Massacesi, Luca; Miller, Ariel; Miller, David H; Montalban, Xavier; Monteyne, Philippe; Mowry, Ellen; Münz, Christian; Nielsen, Nete M; Olsson, Tomas; Oreja-Guevara, Celia; Otero, Susana; Pugliatti, Maura; Reingold, Stephen; Riise, Trond; Robertson, Neil; Salvetti, Marco; Sidhom, Youssef; Smolders, Joost; Sørensen, Per Soelberg; Sollid, Ludvig; Steiner, Israel; Stenager, Egon; Sundstrom, Peter; Taylor, Bruce V; Tremlett, Helen; Trojano, Maria; Uccelli, Antonio; Waubant, Emmanuelle; Wekerle, Hartmut (2018). Environmental modifiable risk factors for multiple sclerosis: Report from the 2016 ECTRIMS focused workshop. MULTIPLE SCLEROSIS JOURNAL, EXPERIMENTAL, TRANSLATIONAL AND CLINICAL, vol. 1, pp. 1-14, ISSN:2055-2173 DOI Accesso ONLINE all'editore

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Cadavid D, Balcer L, Galetta S, Aktas O, Ziemssen T, Vanopdenbosch LJ, Leocani L, Freedman MS, Plant GT, Preiningerova JL, Ziemssen F, Massacesi L, Chai Y, Xu L; RENEW Study Investigators (2018). Predictors of response to opicinumab in acute optic neuritis. ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY, vol. 5, pp. 1154-1162, ISSN:2328-9503 DOI Accesso ONLINE all'editore

Maggi, P; Absinta, M; M, Grammatico; Vuolo, L; Emmi, G; Carlucci, G; Spagni, G; Barilaro, A; Repice, Am; Emmi, L; Prisco, D; Martinelli, V; Scotti, R; Sadeghi, N; Perrotta, G; Sati, P; Dachy, B; Reich, Ds; Filippi, M; Massacesi, L. (2018). Central vein sign differentiates MS from CNS inflammatory vasculopathies.. ANNALS OF NEUROLOGY, vol. 83, pp. 283-294, ISSN:0364-5134 DOI Accesso ONLINE all'editore

Grammatico, M; Carlucci, G; Dallagiacoma, S; Vuolo, L; Repice, AM; Mechi, C; Magnani, E; Barilaro, A; Massacesi, L (2018). The diagnosis of multiple sclerosis with markers of "better explanation": accuracy of the "central vein sign" in uncovering pathogenic mechansms different from inflammatory demyelination. EUROPEAN JOURNAL OF NEUROLOGY, vol. 25, pp. 437-437, ISSN:1351-5101

Cadavid, D.; Balcer, L.; Galetta, S; Aktas, O; Ziemssen, T; Vanopdenbosch, L; Frederiksen, J; Skeen, M; Jaffe, G.J.; Butzkueven, H; Ziemssen, F; Massacesi, L; Chai, Y; Xu, L; Freeman (2017). Safety and efficacy of opicinumab in acute optic neuritis (RENEW): a randomised, placebo-controlled, phase 2 trial.. LANCET NEUROLOGY, vol. 16, pp. 189-199, ISSN:1474-4422 DOI Accesso ONLINE all'editore

Forci, B; Mariottini, A; Mechi, C; Magnani, E; Barilaro, A; Massacesi, L; Repice, A (2017). Real Life comparative evaluation of dimethyl fumarate efficacy and tolerability in relapsing remitting multiple sclerosis patients switching from other treatments. MULTIPLE SCLEROSIS, vol. 23, pp. 874-874, ISSN:1352-4585

Franciotta D, Gastaldi M, Sala A, Andreetta F, Rinaldi E, Ruggieri M, Leante R, Costa G, Biagioli T, Massacesi L, Bazzigaluppi E, Fazio R, Mariotto S, Ferrari S, Galloni E, Perini F, Zardini E, Zuliani L, Zoccarato M, Giometto B, Bertolotto A. (2017). Diagnostics of the neuromyelitis optica spectrum disorders (NMOSD).. NEUROLOGICAL SCIENCES, vol. 38, pp. 231-236, ISSN:1590-1874 DOI Accesso ONLINE all'editore

Maggi, Pietro; Sati, Pascal; Massacesi, Luca (2017). Magnetic resonance imaging of experimental autoimmune encephalomyelitis in the common marmoset.. JOURNAL OF NEUROIMMUNOLOGY, vol. 304, pp. 86-92, ISSN:0165-5728 DOI Accesso ONLINE all'editore

Mariottini, A; Forci, B; Magnani, E; Massacesi, L; Repice, A (2017). Severe disease reactivation in two multiple sclerosis patients after natalizumab withdrawal was not halted by monthly administrations of cyclophosphamide - two case reports. MULTIPLE SCLEROSIS, vol. 23, pp. 923-924, ISSN:1352-4585

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Forci, B; Mariottini, A; Mechi, C; Massacesi, L; Repice, A. (2017). Disease reactivation following fingolimod withdrawal in multiple sclerosis: Two case reports.. MULTIPLE SCLEROSIS AND RELATED DISORDERS, vol. 15, pp. 24-26, ISSN:2211-0348 DOI Accesso ONLINE all'editore

Boffa, G; Sormani, MP; Repice, AM; Curro, D; Capobianco, M; Gualandi, F; Lo Re, M; De Gobbi, M; Innocenti, C; Capello, E; Mariottini, A; Forci, B; Uccelli, A; Barilaro, A; Cottone, S; Bertolotto, A; Saccardi, R; Mancardi, GL; Massacesi, L (2017). Sustained disease remission in multiple sclerosis after autologous haematopoietic stem cell transplantation. The Italian experience. MULTIPLE SCLEROSIS, vol. 23, pp. 307-308, ISSN:1352-4585

M, Grammatico; Carlucci, G; Dalla Giacoma, S; Vuolo, L; Repice, Am; Mechi, C; Magnani, E; Barilaro, A; Fainardi, E; Massacesi, L. (2017). Accuracy of the central vein sign evaluation by brain MRI for the pathologic characterization of multiple sclerosis cases with markers of "better explanation" of the diagnosis.. MULTIPLE SCLEROSIS, vol. 23, pp. 432-432, ISSN:1352-4585

M., Grammatico; Dallagiacoma, S.; Lorenzoni, L.; Carlucci, G.; Repice, A. M.; Mechi, C.; Magnani, E.; Vuolo, L.; Fainardi, E.; Massacesi, L. (2017). Differentiation by MRI between multiple sclerosis and MS-like syndromes with markers of "better explanation" of the diagnosis.. EUROPEAN JOURNAL OF NEUROLOGY, vol. 24, pp. 575-575, ISSN:1351-5101 Accesso ONLINE all'editore

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Massacesi, L (2016). Perivenular Distribution of White Matter Lesions Evaluated by MRI Can Differentiate MS Lesions from Inflammatory Small Vessel Diseases. NEUROLOGY, vol. 86, pp. 121-121, ISSN:0028-3878

Innocenti, C; Barilaro, A; Fani, A; Mariottini, A; Massacesi, L; Repice, AM; Saccardi, R (2016). Purely myeloablative conditioning regimen in aggressive multiple sclerosis: two case reports. BONE MARROW TRANSPLANTATION, vol. 51, pp. S601-S601, ISSN:0268-3369

Saccardi, R; Barilaro, A; Fani, A; Giannini, M; Gozzini, A; Guidi, S; Innocenti, C; Mariottini, A; Nozzoli, C; Portaccio, E; Repice, AM; Amato, MP; Massacesi, L (2016). intermediate intensity regimen in autologous HSCT for severe Multiple Sclerosis: a a large, single center experience. BONE MARROW TRANSPLANTATION, vol. 51, pp. S495-S495, ISSN:0268-3369

Maggi, P; Zellini, F; Barilaro, A; Passeri, A; Massacesi, L (2016). Time Course of Multiple Sclerosis Lesions Visualized with MRI: Insight into Focal Pathology. NEUROLOGY, vol. 86, pp. 569-569, ISSN:0028-3878

Innocenti, C; Barilaro, A; Fani, A; Mariottini, A; Massacesi, L; Repice, AM; Saccardi, R (2016). Impact of new DMAs on the safety profile of patients undergoing autologous haematopoietic stem cell transplantation for Multiple Sclerosis. BONE MARROW TRANSPLANTATION, vol. 51, pp. S290-S290, ISSN:0268-3369

Saccardi, R; Repice, AM; Innocenti, C; Mariottini, A; Amato, MP; Guidi, S; Fani, A; Nistri, R; Giannini, M; Portaccio, E; Barilaro, A; Nozzoli, C; Gozzini, A; Massacesi, L (2016). Intermediate intensity regimen in autologous HSCT for severe multiple sclerosis: a large, single center experience. MULTIPLE SCLEROSIS, vol. 22, pp. 376-377, ISSN:1352-4585

Sati, P.; Oh, J.; Constable, R.T.; Evangelou, N.; Guttmann, C.R.G.; Henry, R.G.; Klawiter, E.C.; Mainero, C.; Massacesi, L.; Mcfarland, H.; Nelson, F.; Ontaneda, D.; Rauscher, A.; Rooney, W.D.; Samaraweera, A.P.R.; Shinohara, R.T.; Sobel, R.A.; Solomon, A.J.; Treaba, C.A.; Wuerfel, J.; Zivadinov, R.; Sicotte, N.L.; Pelletier, D.; Reich, D.S (2016). The central vein sign and its clinical evaluation for the diagnosis of multiple sclerosis: a consensus statement from the North American Imaging in Multiple Sclerosis Cooperative.. NATURE REVIEWS. NEUROLOGY, vol. 12, pp. 714-722, ISSN:1759-4758 DOI Accesso ONLINE all'editore

Salvadori E.; Poggesi A.; Valenti R.; Pracucci G.; Pescini F.; Pasi M.; Nannucci S.; Marini S.; Del Bene A.; Ciolli L.; Ginestroni A.; Diciotti S.; Orlandi G.; Di Donato I.; De Stefano N.; Cosottini M.; Chiti A.; Federico A.; Dotti M.T.; Bonuccelli U.; Inzitari D.; Pantoni L.; Abbate R.; Boddi M.; Cesari F.; Coppo M.; Giusti B.; Gori A.M.; Mascalchi M.; Cecchi P.; Pagni C.; Siciliano G.; Tognoni G.; Formichi P.; Gambetti C.; Giorgio A.; Rossi F.; Stromillo L.; Zicari E.; Zolo P.; Tiezzi A.; Bertini E.; Brotini S.; Guidi L.; Lombardi M.; Mugnai S.; Notarelli A.; Bracco L.; Cadelo M.; Cisbani R.; Gabbani L.; Gori G.; Lambertucci L.; Massacesi L.; Mossello E.; Paganini M.; Piccininni M.; Pinto F.; Pozzi C.; Sorbi S.; Zaccara G.; Borgogni T.; Mancuso M.; Marconi R.; Mazzoni M.; Vista M.; Meucci G.; Bellini G.; Gabrielli L.; Frittelli C.; Galli R.; Gambaccini G.; Bartolini S.; Biagini C.; Caleri V.; Vanni P.; Calvani D.; Giorgi C.; Magnolfi S.; Palumbo P.; Valente C.; Rossi A.; Tassi R.; Boschi S.; Baldacci F. (2016). Operationalizing mild cognitive impairment criteria in small vessel disease: The VMCI-Tuscany Study. ALZHEIMER'S & DEMENTIA, vol. 12, pp. 0-0, ISSN:1552-5260 DOI Accesso ONLINE all'editore

Massacesi, L (2016). Evaluation by brain MRI of white matter perivenular lesions in inflammatory micro-angiopatic ischemia and in demyelinating multiple sclerosis lesions. EUROPEAN JOURNAL OF NEUROLOGY, vol. 23, pp. 86-86, ISSN:1351-5101

Montanari, E.; Rottoli, M.; Maimone, D.; Confalonieri, P.; Plewnia, K.; Frigo, M.; Francia, A.; Pala, A.; Losignore, N. A.; Ragonese, P.; Veneziano, A.; Traccis, S.; Bosco, G.; Dotta, M.; Severi, S.; Ragno, M.; Candeago, R. M.; Feleppa, M.; Stecchi, S.; Bosco, D.; Tola, M. R.; Massacesi, L.; Costantino, G.; Solaro, C. M.; Serrati, C.; Totaro, R.; Coniglio, M. G.; Scarpini, E.; Zuliani, C.; Perla, F.; Ticca, A.; Cottone, S.; Iudice, A.; Koudriavteva, T.; Di Battista, G.; Gasperini, C.; Perin, C.; Meola, G.; Pugliatti, M.; Bandini, F.; Cavalla, P.; Posteraro, F.; Consoli, D. (2016). A 12-month prospective, observational study evaluating the impact of disease-modifying treatment on emotional burden in recently-diagnosed multiple sclerosis patients: The POSIDONIA study. JOURNAL OF THE NEUROLOGICAL SCIENCES, vol. 364, pp. 105-109, ISSN:0022-510X DOI Accesso ONLINE all'editore

Vuolo, L.; Emmi, G.; Carlucci, G.; Repice, A.; Magnani, E.; Spagni, G.; Prisco, D.; Silvestri, E.; Barilaro, A.; Sati, P.; Reich, D.; Massacesi, L. (2016). MRI evaluation of the "central vein sign" in brain white matter lesions of multiple sclerosis and systemic autoimmune diseases.. MULTIPLE SCLEROSIS, vol. 22, pp. 403-404, ISSN:1352-4585 Accesso ONLINE all'editore

Lagi, Filippo; Bartalesi, Filippo; Pecile, Patrizia; Biagioli, Tiziana; Caldini, Anna Lucia; Fanelli, Alessandra; Giannazzo, Giuseppe; Grifoni, Stefano; Massacesi, Luca; Bartoloni, Alessandro; Rossolini, Gian Maria (2016). Proposal for a New Score-Based Approach To Improve Efficiency of Diagnostic Laboratory Workflow for Acute Bacterial Meningitis in Adults. JOURNAL OF CLINICAL MICROBIOLOGY, vol. 54, pp. 1851-1854, ISSN:0095-1137 DOI Accesso ONLINE all'editore

Massacesi, L; Grammatico, M; Vuolo, L; Barilaro, A; Benedetti, MD; La Mantia, L; Milanese, C; Repice, AM; Solari, A; Tedeschi, G; Filippini, G (2016). Comparison of azathioprine and of beta interferon efficacy on measures of brain damage evaluated by MRI in relapsing-remitting multiple sclerosis. EUROPEAN JOURNAL OF NEUROLOGY, vol. 23, pp. 405-405, ISSN:1351-5101

Maggi, P; Mazzoni, L; Moretti, M; Massacesi, L (2015). Gadolinium improves susceptibility weighted imaging vein detection in multiple sclerosis white matter contrast enhancing lesions.. ACTA RADIOLOGICA OPEN, pp. 0-0, ISSN:2058-4601

Maggi, P; Mazzoni, Ln; Moretti, M; Grammatico, M; Chiti, S; Massacesi, L. (2015). SWI enhances vein detection using gadolinium in multiple sclerosis.. ACTA RADIOLOGICA, vol. 4, pp. 0-0, ISSN:0284-1851 DOI Accesso ONLINE all'editore

Giovannelli, I; Martelli, F; Repice, A; Massacesi, L; Azzi, A; Giannecchini, S. (2015). Detection of JCPyV microRNA in blood and urine samples of multiple sclerosis patients under natalizumab therapy.. JOURNAL OF NEUROVIROLOGY, vol. 21, pp. 0-0, ISSN:1355-0284 DOI Accesso ONLINE all'editore

Capobianco, Marco; Re, Marianna Lo; Sangalli, Francesca; Moiola, Lucia; Perini, Paola; Gallo, Paolo; Danni, Maura; Provinciali, Leandro; Repice, Annamaria; Massacesi, Luca; Messina, Silvia; Patti, Francesco; Laroni, Alice; Mancardi, Gian Luigi; Pucci, Eugenio; Calabrese, Massimiliano; Bertolotto, Antonio (2015). Cyclophosphamide Pulse Therapy after Natalizumab Discontinuation for Multiple Sclerosis: a multicenter study.. JOURNAL OF MULTIPLE SCLEROSIS, vol. 2, pp. 0-0, ISSN:2376-0389 DOI Accesso ONLINE all'editore

Capobianco, M.; Lo Re, M.; Sangalli, F.; Moiola, L.; Comi, G.; Perini, P.; Gallo, P.; Danni, M.; Provinciali, L.; Repice, A.; Massacesi, L.; Patti, F.; Messina, S.; Laroni, A.; Mancardi, G. L.; Calabrese, M.; Monaco, S.; Pucci, E.; Giuliani, G.; Bertolotto, A. (2015). Cyclophosphamide pulses therapy after natalizumab discontinuation in Multiple Sclerosis patients. EUROPEAN JOURNAL OF NEUROLOGY, vol. 22, pp. 0-0, ISSN:1468-1331 Accesso ONLINE all'editore

Vuolo, L; Dewey, B; Sati, P; Massacesi, L; Reich, DS (2015). Efficiency of FLAIR* at 1.5T, 3T, and 7T for detecting perivenular lesions in multiple sclerosis (MS). MULTIPLE SCLEROSIS, vol. 21, pp. 210-210, ISSN:1352-4585

Bandieri, L; Vuolo, L; Repice, AM; Grammatico, M; Mechi, C; Massacesi, L (2015). Brain atrophy evaluation in multiple sclerosis: change over time of corpus callosum area is more sensitive and reproducible than whole brain volume. EUROPEAN JOURNAL OF NEUROLOGY, vol. 22, pp. 303-303, ISSN:1351-5101

Mariottini, A; Innocenti, C; Repice, AM; Fani, A; Massacesi, L; Saccardi, R (2015). Safety profile of autologous haematopoietic stem cell transplantation following natalizumab therapy in aggressive forms of multiple sclerosis. MULTIPLE SCLEROSIS, vol. 21, pp. 768-769, ISSN:1352-4585

Muraro, PA; Pasquini, M; Atkins, H; Bowen, J; Farge, D; Fassas, A; Freedman, MS; Georges, GE; Gualandi, F; Hamerschlak, N; Havrdova, E; Kimiskidis, VK; Kozak, T; Mancardi, GL; Massacesi, L; Moraes, D; Nash, RA; Pavletic, S; Ouyang, J; Rovira, M; Saiz, A; Simoes, B; Trneny, M; Zhu, L; Zhong, X; Badoglio, M; Sormani, MP; Saccardi, R (2015). Long term outcomes after autologous hematopoietic stem cell transplantation for treatment of MS. MULTIPLE SCLEROSIS, vol. 21, pp. 63-64, ISSN:1352-4585

Kurukulasuriya, N.; Fernandez, O.; Balcer, L.; Galetta, S.; Aktas, O.; Ziemssen, T.; Vanopdenbosch, L.; Butzkueven, H.; Ziemssen, F.; Massacesi, L.; Chai, Y.; Xu, L.; Freeman, S.; Cadavid, D. (2015). Efficacy for remyelination and safety of anti-lingo-1 monoclonal antibody (biib033) in acute optic neuritis: results from the renew study. JOURNAL OF THE NEUROLOGICAL SCIENCES, vol. 357, pp. e14-e15, ISSN:0022-510X DOI

Clausi, V; Giannecchini, S; Magnani, E; Repice, A; Mechi, C; Martelli, F; Azzi, A; Massacesi, L. (2015). Markers of JC virus infection in patients with multiple sclerosis under natalizumab therapy.. NEUROLOGY® NEUROIMMUNOLOGY & NEUROINFLAMMATION, vol. 2, pp. 1-4, ISSN:2332-7812 DOI Accesso ONLINE all'editore

Vuolo, L.; Emmi, G.; Carlucci, G.; Repice, A. M.; Mechi, C.; Grammatico Di Tullio, M.; Silvestri, E.; Barilaro, A.; Prisco, D.; Emmi, L.; Massacesi, L. (2015). Imaging perivenular distribution can differentiate MS from CNS vasculitis.. MULTIPLE SCLEROSIS, vol. 21, pp. 471-471, ISSN:1352-4585 Accesso ONLINE all'editore

Cadavid, D; Balcer, L; Galetta, S; Aktas, O; Ziemssen, T; Vanopdenbosch, L; Butzkueven, H; Ziemssen, F; Massacesi, L; Chai, Y; Xu, L; Freeman, S (2015). Evidence of remyelination with the anti-LINGO-1 monoclonal antibody BIIB033 after acute optic neuritis. NEUROLOGY, vol. 85, pp. E46-E46, ISSN:0028-3878

Vuolo, L; Repice, AM; Mechi, C; Magnani, E; Forci, B; Massacesi, L (2015). Leptomeningeal enhancement analysis in diagnostic clinical setting. MULTIPLE SCLEROSIS, vol. 21, pp. 210-210, ISSN:1352-4585

Vuolo, L.; Emmi, G.; Carlucci, G.; Repice, A. M.; Mechi, C.; M., Grammatico; Prisco, D.; Silvestri, E.; Barilaro, A.; Emmi, L.; Massacesi, L. (2015). Susceptibility weighted MRI can help differentiating pathogenesis of white matter lesions in MS and CNS inflammatory vasculopathies.. EUROPEAN JOURNAL OF NEUROLOGY, vol. 22, pp. 216-216, ISSN:1468-1331 DOI Accesso ONLINE all'editore

Mancardi GL, Sormani MP, Gualandi F, Saiz A, Carreras E, Merelli E, Donelli A, Lugaresi A, Di Bartolomeo P, Rottoli MR, Rambaldi A, Amato MP, Massacesi L, Di Gioia M, Vuolo L, Currò D, Roccatagliata L, Filippi M, Aguglia U, Iacopino P, Farge D, Saccardi R; (2015). Autologous Hematopoietic Stem Cell Transplantation in Multiple Sclerosis: a phase II trial.. NEUROLOGY, vol. 84, pp. 981-988, ISSN:0028-3878 DOI Accesso ONLINE all'editore

Di Gioia, M; Innocenti, C; Donnini, I; Nozzoli, C; Bosi, A; Guidi, S; Rigacci, L; Repice, A; Massacesi, L; Portaccio, E; Amato, MP; Saccardi, R (2014). CMV AND EBV REACTIVATION AFTER AUTOLOGOUS HAEMOPOIETIC STEM CELL TRANSPLANTATION WITH BEAM CONDITIONING REGIMEN FOR MULTIPLE SCLEROSIS AND LYMPHOMA: A RETROSPECTIVE SINGLE CENTER CASE-CONTROL STUDY. BONE MARROW TRANSPLANTATION, vol. 49, pp. S248-S249, ISSN:0268-3369

María I Gaitán; Pietro Maggi; Jillian Wohler; Emily Leibovitch; Pascal Sati; Ismael L Calandri; Hellmut Merkle; Luca Massacesi; Afonso C Silva; Steven Jacobson; Daniel S Reich. (2014). Perivenular brain lesions in a primate multiple sclerosis model at 7-tesla magnetic resonance imaging.. MULTIPLE SCLEROSIS, vol. 20, pp. 64-71, ISSN:1352-4585 DOI Accesso ONLINE all'editore

Gallina P; Paganini M; Lombardini L; Biggeri A; Marini M; Morelli AM; Bucciantini S; Sarchielli E; Ambrosini S; Mechi C; Romoli AM; Ghelli E; Pradella S; Urbani S; Mazzanti B; Berti V; Giordano GP; Campolo M; Dal Pozzo S; Piacentini S; Saccardi R; Massacesi L; Mascalchi M; Bosi A; Conti R; Porfirio B; Di Lorenzo N; Vannelli GB (2014). Trapianto intracerebrale di striato fetale nella malattia di Huntington: un aggiornamento dell'esperienza clinica italiana. TRAPIANTI, vol. 18, pp. 5-11, ISSN:1590-072X

M Paganini; A Biggeri; AM Romoli; C Mechi; E Ghelli; V Berti; S Pradella; S Bucciantini; D Catelan; R Saccardi; L Lombardini; M Mascalchi; L Massacesi; B Porfirio; N Di Lorenzo; GB Vannelli; P Gallina (2014). Fetal striatal grafting slows motor and cognitive decline of Huntington's disease. JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY, vol. 85, pp. 974-981, ISSN:0022-3050 DOI

Maggi P.; Cummings Macri S.; Gaitán M.; Leibovitch E.; Wohler J.; Knight H.; Ellis M.; Wu T.; Silva A.; Massacesi L.; Jacobson S.; Westmoreland S.; Reich D. (2014). The formation of inflammatory demyelinated lesions in cerebral white matter.. ANNALS OF NEUROLOGY, vol. 76 (4), pp. 594-608, ISSN:0364-5134 DOI Accesso ONLINE all'editore

Laroni A.; Brogi D.; Morra V.B.; Guidi L.; Pozzilli C.; Comi G.; Lugaresi A.; Turrini R.; Raimondi D.; Uccelli A.; Mancardi G.L.; Amato M.P.; Appendino L.; Ardito B.; Avolio C.; Bandini F.; Batocchi A.P.; Bellantonio P.; Benedetti M.D.; Bergamaschi R.; Bortolon F.; Bosco A.; Buccafusca M.; Cargnelutti D.; Cavalla P.; Cavallo R.; Centonze D.; Coniglio M.G.; Costantino G.; Cottone S.; Danni M.C.; De Robertis F.; Deotto L.; Dotta M.; Di Battista G.; Filippi M.M.; Florio C.; Francia A.; Galgani S.; Gallo P.; Ghezzi A.; Giometto B.; Giuliani G.; Grimaldi L.M.E.; Guidotti M.; Iudice A.; Lenzi G.L.; Lorusso L.; Lus G.; Maimone D.; Malentacchi G.M.; Mantegazza R.E.; Massacesi L.; Melato M.; Millefiorini E.; Montanari E.; Patti F.; Perrone P.S.M.; Protti A.; Provera P.; Quattrone A.; Rasi F.; Rosati G.; Rovaris M.; Saccà F.; Salemi G.; Sarchielli P.; Scarpini E.A.; Schoenhuber R.; Serrati C.; Sinisi L.; Sola P.; Spitaleri D.L.A.; Tedeschi G.; Tezzon F.; Tinebra Asti M.C.; Tola M.R.; Totaro R.; Trojano M.; Ulivelli M.; Vecchio M.M.; Zimatore G.B. (2014). Safety of the first dose of fingolimod for multiple sclerosis: results of an open-label clinical trial.. BMC NEUROLOGY, vol. 14, pp. 0-0, ISSN:1471-2377 DOI Accesso ONLINE all'editore

Massacesi L; Tramacere I; Amoroso S; Battaglia M; Benedetti MD; Filippini G; La Mantia L; Repice A M; Solari A; Tedeschi G; Milanese C (2014). Azathioprine versus Beta Interferons for relapsing-remitting multiple sclerosis: a multicentre randomized non-inferiority trial.. PLOS ONE, vol. 9 (11), pp. 113371-113380, ISSN:1932-6203 DOI Accesso ONLINE all'editore

Elena Bonechi;Alessandra Aldinucci;Benedetta Mazzanti;Massimo di Gioia;Anna Maria Repice;Cinzia Manuelli;Riccardo Saccardi;Luca Massacesi;Clara Ballerini (2014). Increased CXCL10 expression in MS MSCs and monocytes is unaffected by AHSCT. ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY, vol. 1 (9), pp. 650-658, ISSN:2328-9503 DOI

Mazzanti, B; Aldinucci, A; Bonechi, E; Boieri, M; Di Gioia, M; Repice, A; Donnini, I; Massacesi, L; Saccardi, R; Ballerini, C (2013). Mesenchymal Stem Cells and Autoimmune Diseases: The Case of Multiple Sclerosis. NEUROLOGY, vol. 80, pp. 5178-5178, ISSN:0028-3878

Giambene, B; Di Tullio, MG; Massacesi, L; Menchini, U (2013). Retinal Nerve Fiber Layer Thickness As Prognostic Indicator For The Conversion To Clinically Definite Multiple Sclerosis In Clinically Isolated Syndrome With Acute Retrobulbar Optic Neuritis. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 54, pp. 2348-2348, ISSN:0146-0404

Valentina Carrai; Irene Donnini; Benedetta Mazzanti; Renato Alterini; Maria Pia Amato; Alessandro Barilaro; Alberto Bosi; Luca Massacesi; Emilio Portaccio; Anna Maria Repice; Giada Rotunno; Riccardo Saccardi. (2013). Immunohistochemistry analysis of bone marrow biopsies in multiple sclerosis patients undergoing autologous haematopoietic stem cells transplantation. CLINICAL NEUROLOGY AND NEUROSURGERY, vol. 115, pp. 1044-1048, ISSN:0303-8467 DOI Accesso ONLINE all'editore

Massacesi L. (2013). Il ruolo delle Agenzie regolatorie nel percorso autorizzativo dei farmaci neurologici in Europa.. Pisa: Primula Multimedia SrL

Simone Giannecchini ; Irene Giovannelli; Valeria Clausi; Anna Repice; Luca Massacesi; Alberta Azzi (2013). Analisi dell’espressione di microRNA prodotti dal Polyomavirus JC.. In: 41° congresso nazionale della Società Italiana di Microbiologia, Riccione, 16-18 Ottobre 2013, SIM, pp. 97-97.

Galante, A; Bonechi, E; Mariottini, A; Aldinucci, A; Biagioli, T; Mechi, C; Repice, A; Massacesi, L; Ballerini, C (2013). CNS inflammation during relapsing remitting multiple sclerosis (RRMS): a molecular and cellular analysis of ex vivo CSF T lymphocyte expansions. MULTIPLE SCLEROSIS, vol. 19, pp. 152-152, ISSN:1352-4585

Maggi, P; Macri, SMC; Gaitan, MI; Leibovitch, E; Wholer, JE; Wu, T; Silva, A; Massacesi, L; Jacobson, S; Westmoreland, S; Reich, DS (2013). The formation of inflammatory demyelinating lesions: MRI and pathology in a primate model of multiple sclerosis. MULTIPLE SCLEROSIS, vol. 19, pp. 427-428, ISSN:1352-4585

Massacesi, L; Tramacere, I; Benedetti, MD; Filippini, G; Lamantia, L; Solari, A; Amoroso, S; Battaglia, M; Tedeschi, G; Milanese, C (2013). Direct Comparison of Azathioprine and beta Interferon Efficacy in Multiple Sclerosis. NEUROLOGY, vol. 80, pp. 1200-1200, ISSN:0028-3878

Alessandra Aldinucci; Antonio Turco; Tiziana Biagioli; Francesca Maria Toma; Daniele Bani; Daniele Guasti; Cinzia Manuelli; Lisa Rizzetto; Duccio Cavalieri; Luca Massacesi; Tommaso Mello; Denis Scaini; Alberto Bianco; Laura Ballerini; Maurizio Prato; Clara Ballerini. (2013). Carbon nanotube scaffolds instruct human dendritic cells: modulating immune responses by contacts at the nanoscale.. NANO LETTERS, vol. 13, pp. 6098-6105, ISSN:1530-6984 DOI Accesso ONLINE all'editore

Massacesi L. (2013). Percorsi assistenziali del paziente con Sclerosi Multipla.. Verona: Maya Idee, ISBN:9788895958439

Mancardi, G.L.; Sormani, M.P.; Di Gioia, M.; Vuolo, L.; Gualandi, F.; Amato, M.P.; Capello, E.; Currò, D.; Uccelli, A.; Bertolotto, A.; Gasperini, C.; Lugaresi, A.; Merelli, E.; Meucci, G.; Motti, L.; Tola, M.R.; Scarpini, E.; Repice, A.M.; Massacesi, L.; Saccardi, R. (2012). Autologous haematopoietic stem cell transplantation with an intermediate intensity conditioning regimen in multiple sclerosis: The Italian multi-centre experience. MULTIPLE SCLEROSIS, vol. 18, pp. 835-842, ISSN:1352-4585 DOI Accesso ONLINE all'editore

Lutterotti A; Jelcić I; Schulze C; Schippling S; Breiden P; Mazzanti B; Reinhardt S; Di Gioia M; Repice A; Massacesi L; Sputtek A; Salinas-Riester G; Kroeger N; Sospedra M; Saccardi R; Zander A; Martin R.; Bosi A. (2012). No proinflammatory signature in CD34+ hematopoietic progenitor cells in multiple sclerosis patients.. MULTIPLE SCLEROSIS, vol. 18 (8), pp. 1188-1192, ISSN:1352-4585 DOI Accesso ONLINE all'editore

Clausi, V.; Martelli, F.; Repice, A.; Mechi, C.; Magnani, E.; Massacesi, Luca; Azzi, Alberta; Giannecchini, Simone (2012). Detection of polyomavirus JC DNA and anti-JCV antibody in MS patients under natalizumab therapy.. MULTIPLE SCLEROSIS, vol. 18, pp. 467-467, ISSN:1352-4585

Valeria, Clausi; Francesco, Martelli; Anna, Repice; Claudia, Mechi; Eliana, Magnani; Massacesi, Luca; Azzi, Alberta; Giannecchini, Simone (2012). Detection of polyomavirus JC DNA and anti-JCV antibody in MS patients under natalizumab therapy.. MULTIPLE SCLEROSIS, vol. 18, pp. 467-467, ISSN:1352-4585

Gian Luigi Mancardi ;Maria Pia Sormani; Massimo Di Gioia; Luisa Vuolo ;Francesca Gualandi; Maria Pia Amato; Elisabetta Capello; Daniela Currò ; Antonio Uccelli; Antonio Bertolotto; Claudio Gasperini; Alessandra Lugaresi ; Elisa Merelli; Giuseppe Meucci; Luisa Motti; Maria Rosaria Tola; Elio Scarpini; Anna Repice A;Massacesi L;Riccardo Saccardi; Alberto Bosi; The Italian BMT Study Group (2012). Autologous haematopoietic stem cell transplantation with an intermediate intensity conditioning regimen in multiple sclerosis: the Italian multi-centre experience.. MULTIPLE SCLEROSIS, vol. 18, pp. 835-842, ISSN:1352-4585 DOI Accesso ONLINE all'editore

Carrai V; Donnini I; Mazzanti B; Alterini R; Amato MP; Barilaro A;Bosi A; Massacesi L; Portaccio E; Repice AM; Rotunno G Saccardi R. (2012). Immunohistochemistry analsis of bone marrow biopies in multiple sclerosis patients undergoing autologous haematopoietic stem cells transplantation.. CLINICAL NEUROLOGY AND NEUROSURGERY, pp. 0-0, ISSN:0303-8467

Massacesi, L; Tramacere, I; Benedetti, MD; Filippini, G; La Mantia, L; Solari, A; Milanese, C (2012). Non-inferiority of azathioprine versus beta interferons for relapsing-remitting multiple sclerosis: a multicentre randomised trial. MULTIPLE SCLEROSIS, vol. 18, pp. 187-188, ISSN:1352-4585

Mancardi, GL; Sormani, MP; Gualandi, F; Saiz, A; Carreras, E; Merelli, E; Donelli, A; Lugaresi, A; Di Bartolomeo, P; Rambaldi, A; Rottoli, M; Amato, MP; Massacesi, L; Di Gioia, M; Vuolo, L; Curro, D; Roccatagliata, L; Capello, E; Uccelli, A; Iacopino, P; Aguglia, U; Filippi, M; Saccardi, R (2012). Autologous Stem Cell Transplantation International Multiple Sclerosis (ASTIMS) trial: a randomised, phase II, controlled, multicentre trial. MULTIPLE SCLEROSIS, vol. 18, pp. 209-209, ISSN:1352-4585

Maggi, P; Leibovitch, E; Gaitan, MI; Wholer, J; Nair, G; Massacesi, L; Jacobson, S; Silva, A; Reich, DS (2012). Blood Brain Barrier Changes Prior to Lesion Formation in a Primate Model of Multiple Sclerosis. ANNALS OF NEUROLOGY, vol. 72, pp. S114-S114, ISSN:0364-5134

Mancardi, GL; Sormani, MP; Gualandi, F; Saiz, A; Carreras, E; Merelli, E; Donelli, A; Lugaresi, A; Di Bartolomeo, P; Rottoli, M; Rambaldi, A; Amato, MP; Massacesi, L; Vuolo, L; Curro, D; Roccatagliata, L; Filippi, M; Russo, C; Iacopino, P; Saccardi, R (2012). Preliminary results of ASTIMS, a prospective randomised Phase II EBMT trial on autologous HSCT in poor prognosis Multiple Sclerosis. BONE MARROW TRANSPLANTATION, vol. 47, pp. S83-S83, ISSN:0268-3369

Maggi, P; Sati, P; Macri, S; Leibovitch, E; Absinta, M; Massacesi, L; Westmoreland, S; Jacobson, S; Silva, A; Reich, DS (2012). Biological origin of MR phase contrast in white matter lesions at 7T. MULTIPLE SCLEROSIS, vol. 18, pp. 150-150, ISSN:1352-4585

Maggi, P; Sati, P; Leibovitch, E; Gaitan, MI; Wholer, J; Macri, S; Massacesi, L; Westmoreland, S; Jacobson, S; Silva, A; Reich, DS (2012). Phase Imaging in Marmoset EAE at 7T Demonstrates Heterogeneity within Focal Lesions. ANNALS OF NEUROLOGY, vol. 72, pp. S115-S115, ISSN:0364-5134

Paolo Zamboni; Antonio Bertolotto; Paolo Boldrini; Patrizia Cenni; Roberto D’Alessandro; Roberto D’Amico; Massimo Del Sette; Roberto Galeotti; Stefania Galimberti; Alessandro Liberati; Luca Massacesi; Donato Papini; Fabrizio Salvi; Silvana Simi; Andrea Stella; Luigi Tesio; Maria Grazia Valsecchi; Graziella Filippini; (2012). Efficacy and safety of venous angioplasty of the extracranial veins for multiple sclerosis. Brave dreams study (brain venous drainage exploited against multiple sclerosis): study protocol for a randomized controlled trial. TRIALS, vol. 13, pp. 183-195, ISSN:1745-6215 DOI Accesso ONLINE all'editore

Gaitán MI; Shea CD; Evangelou IE; Stone RD; Fenton KM; Bielekova B; Massacesi L; Reich DS. (2011). Evolution of the Blood-Brain Barrier in Newly Forming Multiple Sclerosis Lesions.. ANNALS OF NEUROLOGY, vol. 70(1), pp. 22-29, ISSN:1531-8249 DOI

Snowden JA; Saccardi R; Allez M; Ardizzone S; Arnold R; Cervera R; Denton C; Hawkey C; Labopin M; Mancardi G; Martin R; Moore JJ; Passweg J; Peters C; Rabusin M; Rovira M; van Laar JM; Farge D; on behalf of the EBMT Autoimmune Disease Working Party (ADWP) and Paediatric Diseases Working Party (PDWP); Massacesi L. (2011). Haematopoietic SCT in severe autoimmune diseases: updated guidelines of the European Group for Blood and Marrow Transplantation.. BONE MARROW TRANSPLANTATION, vol. 47(6), pp. 1-21, ISSN:0268-3369 DOI

Maggi, P; Gaitan, MI; Wohler, J; Liu, J; Senseney, J; Shea, C; Massacesi, L; Jacobson, S; Silva, A; Reich, DS (2011). Early blood-brain-barrier permeability changes in the normal-appearing white matter of a marmoset model of MS. MULTIPLE SCLEROSIS, vol. 17, pp. S103-S103, ISSN:1352-4585

Saccardi, R; Donnini, I; Repice, A; Maggi, P; Di Gioia, M; Andreoli, E; Bosi, A; Guidi, S; Gozzini, A; Massacesi, L; Amato, MP; Nozzoli, C (2011). CMV and EBV reactivation in autologous haemopoietic stem cell transplantation for severe multiple sclerosis. BONE MARROW TRANSPLANTATION, vol. 46, pp. S378-S379, ISSN:0268-3369

Gaitan, MI; Shea, CD; Evangelou, IE; Stone, RD; Fenton, KM; Bielekova, B; Massacesi, L; Reich, DS (2011). In Vivo Blood-Brain Barrier Evolution of Newly Forming Multiple Sclerosis Lesions. NEUROLOGY, vol. 76, pp. A358-A358, ISSN:0028-3878

Di Gioia, M; Guidi, S; Bosi, A; Amato, MP; Portaccio, E; Repice, A; Barilaro, A; Massacesi, L; Saccardi, R (2011). HSCT for severe multiple sclerosis with BEAM/ATG: impact on female fertility. BONE MARROW TRANSPLANTATION, vol. 46, pp. S379-S379, ISSN:0268-3369

Gaitan, MI; Maggi, P; Wohler, J; Sati, P; Silva, AC; Massacesi, L; Jacobson, S; Reich, DS (2011). 7T MRI reveals the perivascular distribution of lesions in an animal model of multiple sclerosis. MULTIPLE SCLEROSIS, vol. 17, pp. S376-S376, ISSN:1352-4585

Massacesi, L; Filippini, G; Benedetti, D; La Mantia, L; Solari, A; Milanese, C (2011). Randomised controlled direct comparison of azathioprine and beta interferons efficacy in relapsing-remitting multiple sclerosis. MULTIPLE SCLEROSIS, vol. 17, pp. S429-S430, ISSN:1352-4585

Aldinucci A; Biagioli T; Manuelli C; Repice A; Massacesi L; Ballerini C. (2010). Modulating dendritic cells (DC) from immunogenic to tolerogenic responses: a novel mechanism of AZA/6-MP.. JOURNAL OF NEUROIMMUNOLOGY, vol. 218(1-2), pp. 28-35, ISSN:0165-5728 DOI Accesso ONLINE all'editore

Aldinucci A; Rizzetto L; Pieri L; Nosi D; Romagnoli P; Biagioli T; Mazzanti B; Saccardi R; Beltrame L; Massacesi L; Cavalieri D; Ballerini C. (2010). Inhibition of Immune Synapse by Altered Dendritic CellActin Distribution: A New Pathway of Mesenchymal StemCell Immune Regulation.. JOURNAL OF IMMUNOLOGY, vol. 185(9), pp. 5102-5110, ISSN:0022-1767 DOI

Freedman, M; Amato, MP; Atkins, H; Carreras, E; Fassas, A; Griffith, LM; Kerr, D; Martin, R; Massacesi, L; Muraro, P; Nash, R; Pasquini, M; Saccardi, R; Sormani, MP; Mancardi, G (2010). Panel Session Report: Multiple Sclerosis. BONE MARROW TRANSPLANTATION, vol. 45, pp. S8-S10, ISSN:0268-3369

A. Aldinucci; T. Biagioli; B. Mazzanti; L. Pieri; P. Romagnoli; R. Saccardi; D. Cavalieri; L. Massacesi; C. Ballerini (2010). MSCs shift DCs from immunogenic to tolerogenic through contact induced cytoskeleton modifications.. BONE MARROW TRANSPLANTATION, vol. 45 (Suppl. 1), pp. S20-S20, ISSN:0268-3369

Aldinucci, A; Mazzanti, B; Galante, A; Dal Pozzo, S; Saccardi, R; Massacesi, L; Ballerini, C (2010). DIFFERENCES IN MSCS IP-10 PRODUCTION BETWEEN MS PATIENTS AND HEALTHY DONORS. BONE MARROW TRANSPLANTATION, vol. 45, pp. S20-S20, ISSN:0268-3369

Ballerini, C; Galante, A; Biagioli, T; Repice, A; Barilaro, A; Aldinucci, A; Massacesi, L (2010). Antigen Driven T-Cell Response in CSF of Multiple Sclerosis Patients. ANNALS OF NEUROLOGY, vol. 68, pp. S57-S58, ISSN:0364-5134

Sati, P; Silva, AC; Gaitan, MI; Wohler, JE; Evangelou, IE; Massacesi, L; Jacobson, S; Reich, DS (2010). In-Vivo Myelin Water Imaging using T2*Decay at 7T. ANNALS OF NEUROLOGY, vol. 68, pp. S34-S34, ISSN:0364-5134

Mazzanti, B; Cuzzola, M; Di Gioia, M; Fedele, R; Massara, E; Cannata, MC; Dal Pozzo, S; Ballerini, C; Aldinucci, A; Amato, MP; Massacesi, L; Bosi, A; Saccardi, R; Iacopino, P (2010). GENE EXPRESSION ANALYSIS OF PBMNC FROM MS PATIENTS UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION (HSCT). BONE MARROW TRANSPLANTATION, vol. 45, pp. S22-S22, ISSN:0268-3369

Mazzanti, B; Aldinucci, A; Biagioli, T; Barilaro, A; Crescioli, C; Saccardi, R; Massacesi, L; Ballerini, C (2009). Comparing human bone marrow mesenchymal stem cells isolated from MS patients with ND ones: possible impact on MS therapy and immunopathology. EUROPEAN JOURNAL OF NEUROLOGY, vol. 16, pp. 250-250, ISSN:1351-5101

Massacesi, L (2009). Evolution of immune system aberration instigates early treatment of active MS. EUROPEAN JOURNAL OF NEUROLOGY, vol. 16, pp. 14-14, ISSN:1351-5101

’t Hart B.; Massacesi L. (2009). Clinical, pathological and immunologic aspects of the multiple sclerosis model in common marmosets (Callithrix jacchus).. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, vol. 68 (4), pp. 341-355, ISSN:0022-3069 DOI Accesso ONLINE all'editore

Caleri, F; Repice, A; Zellini, F; Barilaro, A; De Cristofaro, MT; Pupi, A; Massacesi, L (2009). Cerebral perfusion abnormalities in multiple sclerosis patients with markers of systemic autoimmunity. EUROPEAN JOURNAL OF NEUROLOGY, vol. 16, pp. 267-267, ISSN:1351-5101

A. Aldinucci; T. Biagioli; L. Pieri; P. Romagnoli; B. Mazzanti; R. Saccardi; L. Massacesi; C. Ballerini (2009). MSCs-DCs interaction: a cell-cell contact mechanism inducing tolerance.. BONE MARROW TRANSPLANTATION, vol. 43 (Suppl. 1), pp. S19-S19, ISSN:0268-3369

Repice, AM; Di Gioia, M; Barilaro, A; Saccardi, R; Donnini, I; Guidi, S; Zellini, F; Massacesi, L (2009). Long term follow-up of autologous stem cell transplantation (HSCT) for the treatment of secondary progressive multiple sclerosis: single centre experience. EUROPEAN JOURNAL OF NEUROLOGY, vol. 16, pp. 267-267, ISSN:1351-5101

Aldinucci, A; Biagioli, T; Manuelli, C; Barilaro, A; Massacesi, L; Ballerini, C (2009). Modulating DC from immunogenic to tolerogenic responses: a novel mechanism of azathioprine (AZA). EUROPEAN JOURNAL OF NEUROLOGY, vol. 16, pp. 250-250, ISSN:1351-5101

E. Bizzoco; F. Lolli; AM Repice; B. Hakiki; M. Falcini; A. Barilaro; R. Taiuti; G. Siracusa; M.P. Amato; T. Biagioli; S. Lori; M. Moretti; A. Vinattieri; P. Nencini; L. Massacesi; S. Matà (2009). Prevalence of neuromyelitis optica spectrum disorder and phenotype distribution.. JOURNAL OF NEUROLOGY, vol. 11, pp. 1891-1898, ISSN:0340-5354 DOI Accesso ONLINE all'editore

I. Luccarini; C. Ballerini; T. Biagioli; F. Biamonti; A. Bellucci; MC. Rosi; C. Grossi; L. Massacesi; F. Casamenti (2008). Combined treatment with atorvastatin and minocycline suppresses severity of EAE. EXPERIMENTAL NEUROLOGY, vol. 211, pp. 214-226, ISSN:0014-4886 DOI

DALFONSO S; BOLOGNESI E; GUERINI F; BARIZZONE N; BOCCA S; CASTELLI L; BERGAMASCHI L; AGLIARDI C; FERRANTE P; NALDI P; LEONE M; CAPUTO D; BALLERINI C; SALVETTI M; GALIMBERTI D; MASSACESI L; TROJANO M; MOMIGLIANO-RICHIARDI P; FERRANTE D. (2008). A sequence variation in the MOG gene is involved in Multiple Sclerosis susceptibility in Italy.. GENES AND IMMUNITY, vol. 9, pp. 7-15, ISSN:1466-4879 DOI

Farina, C; Di Dario, M; Di Stefano, AL; Ballerini, C; Biagioli, T; Franciotta, D; Mantegazza, R; Confalonieri, P; Massacesi, L; Bergamaschi, R; La Mantia, L; Milanese, C; Medico, E (2008). Blood gene signatures in clinically isogated syndromes and multiple sclerosis. NEUROLOGY, vol. 70, pp. A384-A384, ISSN:0028-3878

Mazzanti B; Aldinucci A; Biagioli T; Barilaro A; Urbani S; Dal Pozzo S; Amato MP; Siracusa G; Crescioli C; Manuelli C; Bosi A; Saccardi R; Massacesi L; Ballerini C. (2008). Differences in mesenchymal stem cell cytokine profiles between MS patients and healthy donors: Implication for assessment of disease activity and treatment. JOURNAL OF NEUROIMMUNOLOGY, vol. 199, pp. 142-150, ISSN:0165-5728 DOI

A. Aldinucci; T. Biagioli; L. Pieri; P. Romagnoli; B. Mazzanti; R. Saccardi; L. Massacesi; C. Ballerini (2008). MSCs-DCs interactions: An intimate cell-cell contact.. JOURNAL OF NEUROIMMUNOLOGY, vol. 203, pp. 250-250, ISSN:0165-5728

G.L. Mancardi; R. Saccardi; A. Murialdo; F. Pagliai; F. Gualandi; A. Marmont; M. Inglese; P. Bruzzi; M.P. Sormani; M.G. Marrosu; G. Meucci; L. Massacesi; A. Bertolotto; A. Lugaresi; E. Merelli; M. Filippi. (2007). Intense Immunosuppression Followed by Autologous Stem Cell Transplantation in Severe Multiple Sclerosis Cases: MRI and Clinical Data.. In: R. K. Burt. Stem Cell Therapy for Autoimmune Disease, pp. *-*, *: Landes Bioscience.

ROCCATAGLIATA L; ROCCA M; VALSASINA P; BONZANO L; SORMANI M; SACCARDI R; MANCARDI G; FILIPPI M; FOR THE ITALIAN GITMO-NEURO INTERGROUP ON AUTOLOGOUS STEM CELL TRANSPLANTATION; MASSACESI L. (2007). The long-term effect of AHSCT on MRI measures of MS evolution: a five-year follow-up study.. MULTIPLE SCLEROSIS, vol. 13, pp. 1068-1070, ISSN:1352-4585 DOI

ALDINUCCI A; GERLINI G; FOSSATI S; CIPRIANI G; BALLERINI C; BIAGIOLI T; PIMPINELLI N; BORGOGNONI L; MASSACESI L; MORONI F; CHIARUGI A. (2007). A key role for poly(ADP-ribose) polymerase-1 activity during human dendritic cell maturation.. JOURNAL OF IMMUNOLOGY, vol. 179(1), pp. 305-312, ISSN:0022-1767

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E. Peroni; F. Lolli; B. Mazzanti; M. Pazzagli; B. Bonetti; L. Massacesi; M. Chelli; P. Rovero; A. M. Papini (2003). Towards a therapeutic apheresis in Multiple Sclerosis based on a glycopeptide antigen able to isolate specific autoantibodies.. BIOPOLYMERS, vol. 71, pp. 277-277, ISSN:0006-3525 DOI Accesso ONLINE all'editore

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PAPINI A.M.; MAZZANTI B.; NARDI E.; TRAGGIAI E.; BALLERINI C.; BIAGIOLI T.; KALBACHER H.; BECH H.; DEEG M.; CHELLI M.; GINANNESCHI M.; MASSACESI L.; VERGELLI M.; (2001). Palmitoyl Derivatives of GpMBP Epitopes: T-Cell Response and Peptidases Susceptibility.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 44, pp. 3504-3510, ISSN:0022-2623 DOI

TRAGGIAI E; BIAGIOLI T; ROSATI E; BALLERINI C; MAZZANTI B; BEN NUN A; MASSACESI L; VERGELLI M; (2001). IL-7-enhanced T-cell response to myelin proteins in multiple sclerosis. J. Neuroimmunol.. JOURNAL OF NEUROIMMUNOLOGY, vol. 121, pp. 111-119, ISSN:0165-5728, Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598: DOI

BROADLEY S; SAWCER S; D'ALFONSO S; HENSIEK A; CORADDU F; GRAY J; ROXBURGH R; CLAYTON D; BUTTINELLI C; QUATTRONE A; TROJANO M; MASSACESI L; COMPSTON A; (2001). A genome screen for multiple sclerosis in Italian families.. GENES AND IMMUNITY, vol. 2, pp. 205-210, ISSN:1466-4879, Nature Publishing Group:Brunel Road Houndmills, Basingstoke RG21 6XS United Kingdom:011 44 20 78334000, EMAIL: institutions@natureny.com, INTERNET: http://www.nature.com, Fax: 011 44 20 78434640: DOI

MOLYNEUX PD; BARKER GJ; BARKHOF F; BECKMANN K; DAHLKE F; FILIPPI M; GHAZI M; HAHN D; MACMANUS D; POLMAN C; POZZILLI C; KAPPOS L; THOMPSON AJ; WAGNER K; YOUSRY T; MILLER DH; EUROPEAN STUDY GROUP ON INTERFERON BETA-B IN SECONDARY PROGRESSIVE MS; MASSACESI L; (2001). Clinical-MRI correlations in a European trial of interferon beta-1b in secondary progressive MS.. NEUROLOGY, vol. 57, pp. 2191-2197, ISSN:0028-3878, Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320: DOI

A.M. PAPINI; E. NARDI; B. MAZZANTI; T. BIAGIOLI; C. BALLERINI; E. TRAGGIAI; M. CHELLI; M. GINANNESCHI; H. KALBACHER; M. DEEG; L. MASSACESI; M. VERGELLI (2001). EFFECT OF LIPOCONJUGATION ON MBP PEPTIDE EPITOPES FOR CD4+ T CELL RESPONSIVENESS. In: JEAN MARTINEZ, JEAN-ALAIN FEHRENTZ. PEPTIDES 2000, pp. 69-70, PARIS: Editions EDK, ISBN:9782842540487.

KAPPOS L; POLMAN C; POZZILLI C; THOMPSON A; BECKMANN K; DAHLKE F; THE EUROPEAN STUDY GROUP ON INTERFERON BETA-1B IN SECONDARY-PROGRESSIVE MULTIPLE SCLEROSIS; MASSACESI L; (2001). Final analysis of the European multicenter trial on IFNbeta-1b secondary progressive Multiple Sclerosis.. NEUROLOGY, vol. 57, pp. 1969-1975, ISSN:0028-3878, Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320: DOI

CHIARUGI A; COZZI A; BALLERINI C; MASSACESI L; F. MORONI (2001). Kynurenine 3-mono-oxygenase activity and neurotoxic kynurenine metabolites increase in the spinal cord of rats with experimental allergic encephalomyelitis.. NEUROSCIENCE, vol. 102, pp. 687-695, ISSN:0306-4522, Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010:

MANCARDI G; HART B; ROCCATAGLIATA L; BROK H; GIUNTI D; BONTROP R; MASSACESI L; CAPELLO E; UCCELLI A; (2001). Demyelination and axonal damage in a non-human primate model of multiple sclerosis.. JOURNAL OF THE NEUROLOGICAL SCIENCES, vol. 184, pp. 41-49, ISSN:0022-510X, Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598: DOI

FREEMAN JA; THOMPSON AJ; FITZPATRICK R; HUTCHINSON M; MILTENBURGER C; BECKMANN K; DAHLKE F; KAPPOS L; POLMAN C; POZZILLI C; THE EUROPEAN STUDY GROUP ON INTERFERON BETA-1B IN SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS; MASSACESI L; (2001). IFNbeta-1b in the treatment of secondary progressive Multiple Sclerosis: impact on quality of life.. NEUROLOGY, vol. 57, pp. 1870-1875, ISSN:0028-3878, Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320: DOI

Vergelli M; Mazzanti B; Traggiai E; Biagioli T; Ballerini C; Parigi A; Konse A; Pellicanò G; Massacesi L; (2001). Short-term evolution of autoreactive T-cell repertoire in multiple sclerosis.. JOURNAL OF NEUROSCIENCE RESEARCH, vol. 66, pp. 517-524, ISSN:0360-4012, John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551: DOI

MAZZANTI B.; HEMMER B.; TRAGGIAI E.; BALLERINI C.; MCFARLAND H.F.; MASSACESI L.; MARTIN R.; VERGELLI M.; (2000). Decrypting the Spectrum of Antigen-Specific T-Cell Responses: The Avidity Repertoire of MBP-Specific T-Cells.. JOURNAL OF NEUROSCIENCE RESEARCH, vol. 59, pp. 86-93, ISSN:0360-4012, John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551: DOI

C. Ballerini; D. Campani; G. Rombolà; B. Gran; B. Nacmias; M. P. Amato; G. Siracusa; L. Bartolozzi; S. Sorbi; L. Massacesi (2000). Association of apolipoprotein E polymorphism to clinical heterogeneity of multiple sclerosis.. NEUROSCIENCE LETTERS, vol. 296, pp. 174-176, ISSN:0304-3940

A.M. PAPINI; E. NARDI; S. MAZZUCCO; B. MAZZANTI; E. TRAGGIAI; C. BALLERINI; H. KALBACHER; H. BECK; M. CHELLI; M. GINANNESCHI; L. MASSACESI; M. VERGELLI (2000). LIPOPHILIC MODIFICATIONS OF PEPTIDE EPITOPES: T-CELL RESPONSE AND SUSCEPTIBILITY TO PEPTIDASES. In: GREGG B. FIELDS, JAMES P. TAM, GEORGE BARANY. PEPTIDES FOR THE NEW MILLENIUM, pp. 697-698, Dordrecht/Boston/London, The Netherlands: Kluwer/Escom academic publishers.

D'Alfonso S; Nisticò L; Bocchio D; Bomprezzi R; Marrosu MG; Murru MR; Lai M; Massacesi L; Ballerini C; Repice A; Salvetti M; Montesperelli C; Ristori G; Trojano M; Liguori M; Gambi D; Quattrone A; Tosi R; Momigliano-Richiardi P. (2000). An attempt of identifying MS-associated loci as a follow-up of a genomic linkage study in the Italian population.. JOURNAL OF NEUROVIROLOGY, vol. 6 (S 2), pp. 18-22, ISSN:1355-0284, Taylor & Francis Limited:Rankine Road, Basingstoke RG24 8PR United Kingdom:011 44 1256 813035, EMAIL: madeline.sims@tandf.co.uk, info@tandf.co.uk, INTERNET: http://www.tandf.co.uk, Fax: 011 44 1256 330245:

A. PUPI; SESTINI S; EMMI L; MARCHIONE T; SALVATI G; GOBBI FL; MASSACESI L; MELDOLESI U (2000). Use of technetium-99m hexamethylpropylene amine oxime SPET for the study of cerebral blood flow reactivity after acetazolamide infusion in patients with Behcet's disease.. EUROPEAN JOURNAL OF NUCLEAR MEDICINE, vol. 27, pp. 700-706, ISSN:0340-6997, Springer Verlag Germany:Tiergartenstrasse 17, D 69121 Heidelberg Germany:011 49 6221 3450, EMAIL: g.braun@springer.de, INTERNET: http://www.springer.de, Fax: 011 49 6221 345229: DOI

PUPI A; SESTINI S; DE CRISTOFARO M.T; EMMI L; MARCHIONE T; SALVATI G; LI GOBBI F; MASSACESI L; MELDOLESI U; (2000). Use of technetium-99m hexamethylpropylene amine oxime single-photon emission tomography for the study of cerebral blood flow reactivity after acetazolamide infusion in patients with Behçet’s disease.. EUROPEAN JOURNAL OF NUCLEAR MEDICINE, vol. 27(6), pp. 700-706, ISSN:0340-6997, Springer Verlag Germany:Tiergartenstrasse 17, D 69121 Heidelberg Germany:011 49 6221 3450, EMAIL: g.braun@springer.de, INTERNET: http://www.springer.de, Fax: 011 49 6221 345229:

MOLYNEUX P.D; KAPPOS L; POLMAN C; POZZILLI C; BARKHOF F; FILIPPI M; YOUSRY T; HAHN D; WAGNER K; GHAZI M; BECKMANN K; DAHLKE F; LOSSEFF N; BARKER G.J; THOMPSON A.J; MILLER D.H; THE EUROPEAN STUDY GROUP ON INTERFERON BETA-1B IN SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS; MASSACESI L; (2000). The effect of interferon beta-1b treatment on MRI measures of cerebral atrophy in secondary progressive multiple Sclerosis.. BRAIN, vol. 123, pp. 2256-2263, ISSN:0006-8950, Oxford University Press:Journals Department, Great Clarendon Street, Oxford OX2 6DP United Kingdom:011 44 1865 556767, EMAIL: jnlorders@oup.co.uk, INTERNET: http://www.oup.co.uk, Fax: 011 44 1865 267485: DOI

'T HART B.A.; VAN MEURS M.; BROK H.P.M.; MASSACESI L; BAUER J.; BOON L.; BONTROP R.E.; LAMAN J.D.; (2000). A new primate model for multiple sclerosis in the common marmoset.. IMMUNOLOGY TODAY, vol. 21, pp. 290-297, ISSN:0167-5699, Elsevier Trends Journals:An Imprint of Elsevier Science Limited, The Boulevard, Langford Lane, Kidlington, Oxford 0X5 1GB United Kingdom:011 44 1865 843000, 011 44 1865 843699, Fax: 011 44 1865 843010: DOI

S. MAZZUCCO; E. NARDI; M. CHELLI; M. GINANNESCHI; G. RAPI; A.M. PAPINI; M. VERGELLI; B. MAZZANTI; L. MASSACESI; L. AMADUCCI (1999). SYNTHESIS OF LIPOPEPTIDES OF THE IMMUNODOMINANT EPITOPE HMBP(83-99) CONTAINING AMIDE OR C-C BOND LINKED HYDROPHOBIC CHAINS FOR THE STUDY OF T CELL RESPONSE. LETTERS IN PEPTIDE SCIENCE, vol. 6(1), pp. 51-59, ISSN:0929-5666

MILLER D.H; MOLYNEUX P.D; BARKER G.J; MAC MANUS D.G; MOSELEY I.F; WAGNER K; EUROPEAN STUDY GROUP ON INTERFERON-; B IN SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS; L. MASSACESI (1999). Effect of Interferon-β1b on Magnetic Resonance Imaging Outcomes in Secondary Progressive Multiple Sclerosis: Results of a European Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial.. ANNALS OF NEUROLOGY, vol. 46, pp. 850-859, ISSN:0364-5134 DOI Accesso ONLINE all'editore

A.M. PAPINI; S. MAZZUCCO; D. PINZANI; M. BIONDI; M. CHELLI; M. GINANNESCHI; G. RAPI; B. MAZZANTI; M. VERGELLI; L. MASSACESI; L. AMADUCCI (1999). Lipoderivatives of an immunodominant epitope of myelin basic protein increased T cell responsiveness in Lewis rats.. In: TAM J.P.; KAUMAYA P.T.P.. Peptides: Frontiers of Peptide Science, pp. 700-702, DORDRECHT/BOSTON/LONDON: Kluwer/Escom Academic Publishers, ISBN:9780792351603.

DALFONSO S; NISTIC L; ZAVATTARI P; MARROSU M; MURRU R; LAI M; L. MASSACESI; BALLERINI C; GESTRI D; SALVETTI M; RISTORI G; BOMPREZZI R; TROJANO M; LIGUORI M; GAMBI D; QUATTRONE A; FRUCI D; CUCCA F; MOMIGLIANO RICHIARDI P; TOSI R (1999). A linkage analysis of Multiple Sclerosis with candidate region markers in Sardinian and Continental Italian families.. EUROPEAN JOURNAL OF HUMAN GENETICS, vol. 7, pp. 377-385, ISSN:1018-4813 DOI Accesso ONLINE all'editore

Sabbadini MG; Manfredi AA; Bozzolo E; Ferrario L; Rugarli C; Scorza R; Origgi L; Vanoli M; Gambini O; Vanzulli L; Croce D; Campana A; Messa C; Fazio F; Tincani A; Anzola G; Cattaneo R; Padovani A; Gasparotti R; Gerli R; Quartesan R; Piccirilli M; Farsi A; Emmi E; Passaleva A;Pupi A; Massacesi L (1999). Central nervous system involvement in systemic lupus erythematosus patients without overt neuropsychiatric manifestations.. LUPUS, vol. 8, pp. 11-19, ISSN:0961-2033 DOI Accesso ONLINE all'editore

S. Mata; F. Lolli; S. Mazzucco; A. M. Papini; R. Fioresi; L. Massacesi; M. Vergelli (1999). Antibodies to a glycoderivative of Myelin Oligodendrocyte Glycoprotein (MOG) peptide 30-50 in multiple sclerosis.. NEUROLOGY, vol. 52(6) S2, pp. A401-A401, ISSN:0028-3878

BALLERINI C; B. NACMIAS; ROMBOLA G; MARCON G; MASSACESI L; SORBI S. (1999). HLA A2 allele is associated with age at onset of Alzheimer's disease.. ANNALS OF NEUROLOGY, vol. 45, pp. 397-400, ISSN:0364-5134

S. MAZZUCCO; R. FIORESI; S. MATÀ; M. VERGELLI; M. CHELLI; F. LOLLI; M. GINANNESCHI; F. PINTO; B. MAZZANTI; L. MASSACESI; G. RAPI; A. PAPINI (1999). Glycopeptides of hMOG(30-50) Detect Antibody Response in Multiple Sclerosis and other Neurological Diseases.. In: BAJUSZ S.; HUDECZ F.. Peptides 1998, pp. 46-47, BUDAPEST: Akadèmiai Kiadò.

MAZZUCCO S; MAT S; VERGELLI M; FIORESI R; NARDI E; MAZZANTI B; CHELLI M; LOLLI F; GINANNESCHI M; PINTO F; L. MASSACESI; PAPINI A.M (1999). A synthetic glycopeptide of human myelin oligodendrocyte glycoprotein to detect antibody responses in multiple sclerosis and other neurological diseases.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 9, pp. 167-172, ISSN:0960-894X DOI Accesso ONLINE all'editore

B. Mazzanti; E. Traggiai; B. Hemmer; R. Martin; L. Massacesi; M. Vergelli (1999). The affinity spectrum of myelin basic protein reactive T cells.. In: Gambi D., Muraro P.A., Lugaresi A.. Advances in the immunopathogenesis of multiple sclerosis, pp. 3-10, Milano: Springer Milan, ISBN:9788847000674. DOI Accesso ONLINE all'editore

LAMAN J.D; VAN MEURS M; SCHELLEKENS M.M; DE BOER M; MELCHERS B; L. MASSACESI; LASSMANN H; KLAASSEN E; T HART B (1998). Expression of accessory molecules and cytokines in acute EAE in marmoset monkeys (Callithrix jacchus).. JOURNAL OF NEUROIMMUNOLOGY, vol. 86, pp. 30-45, ISSN:0165-5728 DOI Accesso ONLINE all'editore

GRAN B.; MASSACESI L.; SOTTINI A.; QUIRÒS-ROLDAN E.; BETTINARDI A.; SIGNORINI S.; PRIMI D.; BALLERINI C.; TAIUTI R.; AMADUCCI L.; L. MASSACESI (1998). Detection of skewed T-cell receptor V-beta gene usage in the peripheral blood of patients with multiple sclerosis.. JOURNAL OF NEUROIMMUNOLOGY, vol. 85, pp. 22-32, ISSN:0165-5728, Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598:

EUROPEAN STUDY GROUP ON INTERFERON BETA-B IN SECONDARY PROGRESSIVE MS; L. MASSACESI (1998). Placebo-controlled multicentre randomised trial of Interferon beta-1b in treatment of secondary progressive multiple sclerosis.. THE LANCET, vol. 352, pp. 1491-1497, ISSN:0140-6736 DOI Accesso ONLINE all'editore

T HART B; BAUER J; MULLER H.J; MELCHERS B; NICOLAY K; BROK H; BONTROP R; LASSMANN H; L. MASSACESI (1998). Histopathological characterization of magnetic resonance imaging-decectable brain white matter lesions in a primate model of multiple sclerosis.. THE AMERICAN JOURNAL OF PATHOLOGY, vol. 153, pp. 649-663, ISSN:0002-9440 DOI Accesso ONLINE all'editore

CASCINO I; BALLERINI C; AUDINO S; ROMBOL G; L. MASSACESI; COLOMBO G; SCORZA SMERALDI R; DALFONSO S; MOMIGLIANO RICHIARDI P; TOSI R; RUBERTI G (1998). Fas Gene Polymorphisms are not associated with Systemic Lupus Erythematosus, Multiple Sclerosis and HIV Infection.. DISEASE MARKERS, vol. 13, pp. 221-225, ISSN:0278-0240 Accesso ONLINE all'editore

A.M. PAPINI; S. MAZZUCCO; R. FIORESI; E. NARDI; M. GINANNESCHI; M. CHELLI; S. MATÀ; F. LOLLI; F. PINTO; B. MAZZANTI; L. MASSACESI; M. VERGELLI (1998). [Asn31(N-beta-D-Glucopyranosyl)]hMOG(30-50): an antigen to identify anti-hMOG peptide antibodies in multiple sclerosis patients.. In: 10th International Congress of Immunology, New Delhi, India, November 1-6, 1998, Monduzzi Editore, International Proceedings Division Bologna, pp. 1239-1244, ISBN:9788832311013

VERGELLI, M., OLIVOTTO, J., CASTIGLI, E., GRAN B., A; RAIMONDI, L.; R. PIRISINO; AMADUCCI, L.; MASSACESI, L. (1997). Immunosuppressive activity of 13-cis-retinoic acid in rats: aspects of pharmacokinetics and pharmacodynamics.. IMMUNOPHARMACOLOGY, vol. 37, pp. 191-197, ISSN:0162-3109, Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598:

L. Massacesi (1996). L’encefalomielite autoimmune sperimentale.. In: A. Federico, P. Annunziata. Neurobiologia e Neuroimmunologia Clinica, pp. 85-93, Roma: CIC edizioni Internazionali.

L. MASSACESI; GENAIN C.P; PARRITZ D.L; CANFIELD D; LETVIN N. AND HAUSER S.L (1995). Active and passively induced experimental autoimmune encephalomyelitis in common marmosets: a new model for multiple sclerosis.. ANNALS OF NEUROLOGY, vol. 37, pp. 519-530, ISSN:0364-5134 DOI Accesso ONLINE all'editore

HOHLFELD R; LONDEI M; L. MASSACESI; SALVETTI M (1995). T-cell autoimmunity in multiple sclerosis.. IMMUNOLOGY TODAY, vol. 16, pp. 259-261, ISSN:0167-5699 DOI Accesso ONLINE all'editore

D.CAMPANI;L.MASSACESI;A.BONELLI;M.BATTAGLIA;L.AMADUCCI (1995). COLLECTION OF NERVOUS TISSUE FOR BRAIN BANTS: ETHICAL AND LEGAL ISSUE. In: E.B.B.N. AND XXXI CONGRES OF I.A.N., PAVIA, 21-24 GIUGNO 1995, .., vol. ABSTRACT E.B.B.N. AND XXXI CONGRES OF I.A.N., pp. 36-36.

L. Massacesi; M.P. Amato; L. Amaducci (1994). Immunosuppression in multiple sclerosis state of art and future perspectives. In: L. Massacesi, M.P. Amato, L. Amaducci. A multidisciplinary approach to myelin diseases II, pp. 255-259, New York: Salviati, Plenum Press.

L. Massacesi; MP. Amato; L. Amaducci (1994). Immunosuppression in multiple sclerosis: state of the art and future perspectives. In: A multidisciplinary approach to myelin diseases II. New York: S. Salvati

GENAIN C.P; PARRITZ D; HOA NGUYEN M; L. MASSACESI; IOSHI N; FERRANTE R; HOFFMAN K; MOSELEY M; LEVTIN N; HAUSER S (1994). In healthy primates, circulating autoreactive T-cells mediate autoimmune disease.. THE JOURNAL OF CLINICAL INVESTIGATION, vol. 94, pp. 1339-1345, ISSN:0021-9738 DOI Accesso ONLINE all'editore

SALVETTI M; BUTTINELLI C; L. MASSACESI; WEKERLE H (1993). New approaches to the study of T-cell autoimmunity in multiple sclerosis.. JOURNAL OF NEUROIMMUNOLOGY, vol. 47, pp. 203-205, ISSN:0165-5728 DOI Accesso ONLINE all'editore

DA VICO S; L. MASSACESI; AMADUCCI L (1993). Survey of the italian neurological output in the three years 1989-1991.. ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES, vol. 14, pp. 595-598, ISSN:0392-0461 DOI Accesso ONLINE all'editore

Massacesi, L.; Vergelli, M; Zehetbauer, B; Liuzzi, G.M; Olivotto, J; Ballerini, C; Uccelli, A; Mancardi, L; Riccio, P; Amaducci, L (1993). Induction of experimental autoimmune encephalomyelitis in rats and immune response to myelin basic protein in lipid bound form.. JOURNAL OF THE NEUROLOGICAL SCIENCES, vol. 119, pp. 91-98, ISSN:0022-510X DOI Accesso ONLINE all'editore

YU J.S; PANDEY J. P; L. MASSACESI; LINCOLN R; USUKU K; SEBOUN E; HAUSER S.L (1993). Segregation of Immunoglobulin heavy Chain constant region genes in Multiple sclerosis sibling pairs.. JOURNAL OF NEUROIMMUNOLOGY, vol. 42, pp. 113-116, ISSN:0165-5728 DOI Accesso ONLINE all'editore

LOLLI F; LIUZZI G.M; VERGELLI M; L. MASSACESI; BALLERINI C; AMADUCCI L; RICCIO P (1993). Antibodies specific for the lipid-bound form of myelin basic protein during experimental autoimmune encephalomyelitis.. JOURNAL OF NEUROIMMUNOLOGY, vol. 44, pp. 69-75, ISSN:0165-5728 DOI Accesso ONLINE all'editore

SALVETTI M; L. MASSACESI (1992). Experimental allergic encephalomyelitis and multiple sclerosis: immunoregulatory mechanisms and T cell repertoires.. CELLULAR IMMUNOLOGY, vol. 142, pp. 217-219, ISSN:0008-8749 DOI Accesso ONLINE all'editore

L. MASSACESI; PARRITZ D; JOSHI N; LETVIN N; HAUSER S.L (1992). Experimental allergic encephalomyelitis in Cynomolgus Monkeys: quantitation of T-cell responses in peripheral blood.. THE JOURNAL OF CLINICAL INVESTIGATION, vol. 90, pp. 399-404, ISSN:0021-9738 DOI Accesso ONLINE all'editore

RISKIND P; L. MASSACESI; DOOLITTLE T.H; HAUSER S.L (1991). The role of prolactin in autoimmune demyelination: suppression of experimental allergic encephalomyelitis by bromocriptine.. ANNALS OF NEUROLOGY, vol. 29, pp. 542-547, ISSN:0364-5134 Accesso ONLINE all'editore

L. MASSACESI; CASTIGLI E; VERGELLI M; OLIVOTTO J; ABBAMONDI A.L; SARLO F; AMADUCCI L (1991). Immunosuppressive activity of 13-cis retinoic acid and prevention of experimental autoimmune encephalomyelitis in rats.. THE JOURNAL OF CLINICAL INVESTIGATION, vol. 88, pp. 1331-1337, ISSN:0021-9738 DOI Accesso ONLINE all'editore

L. MASSACESI; ABBAMONDI A.L; RAIMONDI L; GIORGI C; AMADUCCI L (1988). Lysosomal enzymes in experimental allergic encephalomyelitis: time course and evidence of the source.. NEUROCHEMICAL RESEARCH, vol. 13, pp. 165-169, ISSN:0364-3190 DOI Accesso ONLINE all'editore

L. MASSACESI; ABBAMONDI A.L; GIORGI C; SARLO F; LOLLI F; AMADUCCI L (1987). Suppression of experimental allergic encephalomyelitis by retinoic acid.. JOURNAL OF THE NEUROLOGICAL SCIENCES, vol. 80, pp. 55-64, ISSN:0022-510X DOI Accesso ONLINE all'editore

MASSACESI L; ABBAMONDI AL; GIORGI C; SARLO F; F. LOLLI; AMADUCCI L. (1987). Suppression of experimental allergic encephalomyelitis by retinoic acid.. JOURNAL OF THE NEUROLOGICAL SCIENCES, vol. 80, pp. 55-64, ISSN:0022-510X, Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598:

SMITH M.E; SOMERA F.P; SALDIVAR R; L. MASSACESI; TROTTER J (1984). DNA changes in spinal cords of rats with experimental allergic encephalomyelitis.. JOURNAL OF NEUROCHEMISTRY, vol. 43, pp. 1635-1641, ISSN:0022-3042 DOI Accesso ONLINE all'editore

F. Cambi; L. Massacesi; L. Amaducci (1982). La sclerosi multipla malattia degli anticorpi senza senso.. AGGIORNAMENTO MEDICO, vol. 5, pp. 39-45, ISSN:0392-3002

Raimondi L, Banchelli Soldaini G, Buffoni F, Ignesti G, Massacesi L, Amaducci L, Friedmann CA. (1982). Rhein and derivates. In vitro studies on their capacity to inhibit certain proteases.. PHARMACOLOGICAL RESEARCH COMMUNICATIONS, vol. 14, pp. 103-112, ISSN:0031-6989

Luca MASSACESI

Biography

LUCA MASSACESI, PROFESSIONAL BIOGRAPHY
Current positions
Dr. Luca Massacesi, MD, has been and currently is a full professor of Neurology at the Department of Neurosciences of the University of Florence since 2005 and Director of the Department of Urgent Neurology (formerly Neurology 2) of the Careggi University Hospital, since 2008, in Florence, Italy. In addition Prof. Massacesi Coordinates the Research Area of the Careggi Univeristy Hospital in Florence.

Clinical Professional Summary
As Professor of Neurology od the University of Florence the main activity of Prof Massacesi are research and teaching. As for research the main focus is on inflammatory diseases of the nervous system (as for instance multiple sclerosis)and translation to patients of the results of this activity. Prof Massacesi however - also board-certified in Neurology since 1986 and in Clinical Immunology since 1990 -, has relevant clinical duties as the Chairman of one of the Neurology Departments of the Careggi University Hospital and as such he is in charge of diagnosis and treatment of any neurological disease of adult peple. In addition - through the outpatient clinic - he is also in charge of thousands of chronic patients with inflammatory diseases of the nervous system, both peripheral and central, as multiple sclerosis (MS) and the related disorders, chronic vasculitis of the nervous system (CNS), encephalitis, inflammatory peripheral neuropaties, miastenic syndromes. In addition - as Coordinator of the recently established Research Area of the Careggi University Hospital, Prof. Massacesi is in charge of coordinating the support programs for clinical research in this Hospital

Reasearch anc Professional milestones
- Animal model of multiple sclerosis. Prof. Massacesi late in the ‘80es spent his post-doctoral fellowship at the Massachusetts General Hospital and Harvard University (Boston Ma, USA) late in the eighties, critically contributing to the development and the immunological characterization of new animal models of multiple sclerosis (MS) as the experimental autoimmune encephalomyelitis (EAE) in non-human primates, now internationally renowned as a reference in the field.
- The European network on T-cell autoimmunity in multiple sclerosis. After his postdoctoral fellowship he was hired by by the Florence University and the Careggi University Hospital. Applying from this Intitutions he became the Project Leader of the “European Concerted Action on T-cell autoimmunity in Multiple Sclerosis”, a multicentric study funded by the R&D program of the Directorate General XII of the European Union Commission (by a program equivalent to the current European Research Council grants. Beside coordination of the network, Prof. Massacesi was in charge of the EAE model that was impemented in a Duch primate center, that allowed the development of fundamental hypotheses on the pathogenic mechanisms of MS (role of B as well as of T lymphocytes in the effector mechanisms of brain lesion development; histological basis and the kinetics of the brain MS lesion formation that later on led to the discovery of the central vein sign (CVS), the MRI marker specific of MS; c the compartmentalization of immune response in the CNS in the course of MS chronic brain lesions.
o B and T lymphocytes in MS pathogenesis. The role of B lymhocytes and their relation with T lymphocytes in the effector mechanisms leading to the MS brain lesion development, that led to the discovery of the efficacy of CD20+B-cell depletion in the therapy of MS was characterized by his Mentor professor Stephen Hauser in marmoset EAE, the nineties.
o The Central Vein Sign. after in 2009 Prof. Massacesi spent one sabbatical year at the Neuroimmunology Branch of the National Institutes of Helth (Bethesda, Md, USA), Prof. Massacesi indeed remarkably contributed to the characterization and validation of the CVS, by a project led Dr. Daniel Reich, chief of the Translational Neuroradiology Branch of the same institute - This marker is now remarkably improving the specificity of the otherwise poorly specific MS diagnostic criteria.
o Compartmentalization of the immune response in the CNS during the course of MS. The data generated in the EAE indudced in non-humen primates, provided the experimental data that supported the development of the pathogenic hypothesis that chronic progression of MS disability is based on the compartmentalization and chronicization of inflammatory lesions in the CNS. This hypothesis eventually led to the discovery of one critical MRI marker of this mechanism - the Paramagnetic Rim Lesions (PRL) - and to the related comprehension of how disability can progress independently from relapses
- Contribution to neuroimmunology. The broadly recognized interdisciplinary clinical expertise of Prof. Massacesi, in the last decades, also contributed to the development of basic and clinical neuroimmunology as a new independent field, eventually renowned as one of the most innovative subspecialties of the whole neurology. In many neurological scientific societies, this understanding led to the development of some of the most participated study groups, as in the Italian Society of Neurology (SIN) and in the European Academy of Neurology (EAN). Both of these groups have been chaired by Prof Massacesi.
- Clinical trials. Over the last two decades, the scientific interests of Professor Massacesi drifted from translational to mainly clinical, leading a large number of independent studies. Among these a multicentric independent Italian RCT, funded by the Italian Medicine Agency (AIFA) that proved the equivalent efficacy in MS of an old inexpensive immunosuppressive agent (azathioprine) vs interferon beta.
- Medicinal drugs regulatory experience. For his original and remarkable expertise in clinical trials coupled to his independence from private interests on the field, during the last two decades, Prof. Massacesi was appointed by the European Medicines Agency (EMA) as core member of the Scientific Advisory Group (SAG-) Neurology and up to a few years ago, he was also a consultant for neurological medications of AIFA. These appointments allowed Professor Massacesi to consult EMA on Marketing Authorizations and AIFA on reimbursement for tens of medicines for neurological diseases, thus developing a unique record on medicinal drugs marketing authorization at the European level and on reimbursement authorization at the national level.

Publishing and editorial activity.
The above-mentioned achievements generated about 250 publications by Prof. Massacesi, the vast majority of them in international peer-reviewed scientific journals. In addition, prof Massacesi is part of the Editorial Board of two international scientific journals specialized in the neurology field.

Future perspectives.
The long academic and consulting career of Professor Massacesi, besides the above-described scientific achievements, was characterized by international renown, independence from private interests as proven by the number of independent clinical trials, mainly in MS. The large number of sponsored lectures and consultations for private entities made in the past years have always been conducted, fulfilling the strict requirements on conflict of interest prevention of the University of Florence and of the Italian laws and of the above-mentioned regulatory agencies.

Luca MASSACESI

Curriculum

Curriculum Vitae Europass

Personal Data
Name		Luca Massacesi
Address		Department of Neurosciences, Drug and Child Health - University of Florence; Dept. Neurology II, Careggi University Hospital. Largo Brambilla 3 - 50134, Florence, Italy
Phone		+39 0557947927
E-mail		massacesi@unifi.it
Nazionality		Italian
Date of Birth

Current Position
Name of the employer		University of Florence, Florence, Italy
Sector		Department of Neurosciences, Drug and Child Health
Position held		Full professor of Neurology

• Name of the employer		Careggi University Hospital - University of Florence
• sector		Department Neurology II
• Occupation or position held		Director

Main skills

Principal areas of expertise

Research clinical care and teaching in Neurology and particularly in Neuroimmunology with main interests in multiple sclerosis and related disorders, encephalitis, CNS vasculitis and in general in inflammatory diseases of the Nervous System.
Immunotherapies including autologous hematopoietic stem cell transplantation.
Imaging of the Central Nervous System.
Management and evaluation of clinical studies.
Drug evaluation and drug regulatory processes.
Clinical Management and Governance.
Ethic issues of clinical and preclinical research.

Work Experience (Academic)

• Dates (from – to)	1984 -1990
• Name of employer	Italian National Research Council and Clinica Malattie Nervose e Mentali, University of Florence
Sector	Neurology
Occupation or position held	Research fellow
Main activities and responsibilities	Research

Dates (from – to)	1988-1991
Name and address of employer	Massachusetts General Hospital - Harvard University, Boston, Ma, USA
Sector	Neuroimmunology Unit, Dept. of Neurology
Occupation or position held	Postdoctoral fellow.
Main activities and responsibilities	Research

Dates (from-to)	1995-2001
Name of employer	University of Florence – Florence, Italy
Sector	Department of Neurological e Psychiatric Sciences,
Occupation or position held	Assistant Professor (equivalent) of Neurology
Main activities and responsibilities	Research, teaching, clinical activity

Dates (from-to)	2001-2005
Name of the employer	University of Florence, Florence, Italy
Sector	Department of Neurological e Psychiatric Sciences
Occupation or position held	Associate Professor of Neurology
Main activities and responsibilities	Research, teaching, clinical activity

Dates (from-to)	2005- today
Name of the employer	University of Florence, Florence, Italy
Type of business or sector	Department of Neurological e Psychiatric Sciences-University of Florence (since 2013, Dept. of Neurosciences Drugs anch Child Health)
Occupation or position held	Full Professor of Neurology.
Main activities and responsibilities	Research, teaching, clinical activity

Dates (from-to)	2008-2012
Name of the employer	University of Florence
Type of business or sector
Occupation or position held	Director
Main activities and responsibilities	Research teaching, Research management.

Dates (from – to)	2008-2012
Name and address of employer	University of Florence
Type of business or sector	Resident Program in Neurophysiopathology
Occupation or position held	Director
Main activities and responsibilities	Teaching and tutorship of clinical activity

Dates (from – to)	2009-2010
Name of the employer	National Institute of Health, Bethesda, MD, USA
Type of business or sector	NINDS, Neuroimmunology Branch
Occupation or position held	Adjunct Scientist
Main activities and responsibilities	Research

Dates (from – to)	2010-2013
Name of the employer	National Institute of Health, Bethesda, MD, USA
Sector	NINDS, Neuroimmunology Branch
Occupation or position held	Special Investigator
Main activities and responsibilities	Research

Dates (from – to)	2016-2020
Name of the employer	University of Florence
Sector	Council of Discipline:
Occupation or position held	member
Main activities and responsibilities	Consulting the University of Florence Rector on discipline violations of Professors and Researchers.
Dates (from-to)	2018-today
Name of the employer	University of Florence-Careggi University Hospital
Sector	Conflict of interest evaluation committee (COVACI)
Occupation or position held	Delegate of the University of Florence Rector.
Main activities and responsibilities	Evaluation of potential conflict of interests of Staff Physicians and of University Professors and Researchers involved in clinical activities.
Dates (from-to)	2020- today
Name of the employer	University of Florence
Sector	Academic Senate member
Occupation or position held Main activities and responsibilities	Biomedical Area representative Control and collaboration to programming, regulating, and coordinating the activities of the Florence University Government.



Work Experience (Clinical)
Professional Registration	Ordine Medici of Florence, 07156
Dates (from – to) *Name of employer*	1983-1984 Italian Army-Florence Army Hospital
• Sector	Army Health Corp
• Occupation or position held Main activities and responsibilities	Lieutenant Staff Physician - Neurology Dept.
Dates (from – to)	1991-2008
Name of employer	Careggi University Hospital
Sector	Department of Neurology 1
Occupation or position held Main activities and responsibilities	Staff Neurologist clinical activity, clinical research, teaching,
Dates (from – to)	2008- today
Name of the employer	Careggi University Hospital
Sector Occupation or position held Main activities and responsibilities	Department Neurology 2: Director clinical activity, clinical management, clinical research, teaching,

Dates (from – to)	2012-2014
Name of the employer	Careggi University Hospital
Sector Occupation or position held	Department of Neurosciences Director
Main activities and responsibilities	clinical governance, clinical management

Education and academic background

• Date	1975-1982
Name and type of organization providing education and training	University of Florence
• Principal subjects/occupational skills covered	School of Medicine and Surgery
• Title of qualification awarded	Degree in Medicine and Surgery
• Level in national classification	110/110 cum laude

• Date	1982-1986
• Name and type of organization providing education and training	University of Florence
• Principal subjects/occupational skills covered	Resident Program in Neurology
• Title of qualification awarded	Board Certificate in Neurology
• Level in national classification	70/70 cum laude

• Date	1988-1990
Name and type of organization providing education and training	University of Florence
• Principal subjects/occupational skills covered	Resident Program in Clinical Immunology
• Title of qualification awarded	Board Certificate in Clinical Immunology
• Level in national classification	70/70 cum laude

Date	1982
• Name and type of organization providing training	Stanford University, Palo Alto. Ca, USA.,
sector	Neurology Department, Laboratory of Neurochemistry
Occupation or position held	visiting fellow.
Main activities and responsibilities	research

Date	1985
Name and type of organization providing training	National Institute of Health, Bethesda, MD, USA
sector	NINDS, Neuroimmunology Branch
Occupation or position held	visiting fellow
Main activities and responsibilities	research

Further scientific activities
1993-1994	- European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) executive committee: member
1993-2014	- Italian Multiple Sclerosis Society (AISM) Scientific Committee/Research and Evaluation Committee.; member
1994-1997	- R&D program of the del DG XII EU Commission Project Leader of the Concerted Action: "T-cell Autoimmunity in Multiple Sclerosis",
1997-1999	- Studio multicentrico italiano dell'Associazione Italiana Sclerosi Multipla (AISM): “Centralized Facility for genetic studies in Multiple Sclerosis". Coordinator
1997-2013	- Florence University-Magnetic Resonance Interdipartimental Center, steering committee: member
1999-2000	- International Federation of Multiple Sclerosis Societies: Scientific Program Committee; member of the Medical Advisory Board.
1995-2001	- Biomedical Primate Research EU Large Scale Facility, Rijswijk, Nederland; member of the Scientific Committee.
1998-2002	- Multicentric Italian Randomized Clinical Trial: “Open randomized clinical study on different doses of bIFN1a, also in association with Azathioprine, in patients with relapsing-remitting multiple sclerosis”: National coordinator
2006-2011		- Non-profit multicentric clinical RCT, sponsored by the Italian Medicine Agency (AIFA) “Randomized controlled study of Azathioprine versus Interferon beta in relapsing-remitting multiple sclerosis”. Scientific coordinator.
2010-2016		- Data and Safety monitoring board (DSMB) of the National Institutes of Health phase II intramural clinical study: Investigating the mechanism of action of DAC HYP (Daclizumab) in the treatment of highly inflammatory multiple sclerosis: Chairman.
2009-2016		- Agenzia Italiana del Farmaco (AIFA; Italian Meidicines Agency), Rome, Italy; Scientific Advisory Committee on Neurosciences: member.
2011-2018		- Non-profit multicentric clinical trial funded by the Emilia- Romagna regional Government: “Multicentric RCT for the evaluation of efficacy and safety of extracranial vein unblocking in the treatment for multiple sclerosis”. Member of the steering committee.
2009- 2025		- European Medicines Agency (EMA), Amsterdam, The Nederlands; Scientific Advisory Group – Neurology, core member.
2014-2023		- University of Florence - Magnetic Resonance Interdipartimental Center (CIRM): Director.
2015-2016		- Agenzia Italiana del Farmaco (AIFA; Italian Medicines Agency) national Registry on Natalizumab, scientific committee: member
2016-2020		- European Academy of Neurology - Scientific Panel on Neuroimmunology: co-chairman
2016-2018 2020-2023 2018-2020		- Italian Society of Neurology (Società Italiana Neurologia; SIN), Tuscan regional section: coordinator. - Italian College of the Professors of Neurology: Steering Committee member. - University of Florence College of Discipline: member
2018-2022		- University of Florence/Careggi University Hospital Conflict of Interest Evaluation Committee: member
2020-2024		- University of Florence Academic Senate: Biomedical Area representative.
2021-2025 2020-27 2020- 2023 2023-2023 2024-today 2025-today		- Italian Society of Neurology (Società Italiana Neurologia; SIN), Neuroimmunology Study Group: coordinator - European Academy of Neurology - Scientific Panel on Neuroimmunology: delegate of the Italian Society of Neurology Italian college of the Full professors of Neurology: member of the steering committee. Italian college of the Full professors of Neurology: secretary of the steering committee. University of Florence – Biomedical Imaging Interdipartimental Center (CIRIB): member of the steering committee. Careggi University Hospital Research Support Area: Director

Teaching activity: University of Florence

Year

Teaching Courses

Subject

- 1995-2025,

- 2005-2025,

- 2005-2018,

- 2005-2009,

- 1995-2025,

- 2005-2012,

- 2009-2025,

- 2012-2025

- 2015-2025

- 2018-2025

School of Health Sciences,

Medicine and Surgery program

School of Health Sciences, Dentistry program

School of Health Sciences, Nursery Sciences program.

School of Psychology, Experimental Psychology program.

Resident program in Neurology.

Resident program in Neuro-physio-pathology

Resident program in Emergency Medicine:

Resident program in Neurosurgery

Resident program in Psychiatry

Resident program in Ophthalmology

Clinical Neurology;

Thesis tutorship: n.= 59

Clinical Neurology;

Clinical Neurology

Clinical Neurology;

Clinical Neurology

- 1995-2025

- 2009- 2014

PhD program inNeurosciences,

Member of the Teaching committee;

Coordinator

Thesis tutorship: n= 30

SCIENTIFIC SOCIETY AFFILIATION

- Italian Society of Neurology (Società Italiana di Neurologia; SIN).

- European Academy of Neurology

- Italian Association of Neuroimmunology (Associazione Italiana di Neuroimmunologia; AINI)

- International Society of Neuroimmunology.

REVIEWER FOR:

Italian Multiple Sclerosis Foundation, Dutch Multiple Sclerosis Society, Singapore Medical Research Council,

Italian Ministry of University and Research.

Italian Multiple Sclerosis Foundation.

National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA

SCIENTIFIC JOURNAL EDITORIAL BOARD MEMBER:

Past: - Multiple Sclerosis International; - Multiple Sclerosis and Neuroimmunology.

Current: Neuronal Circuits; Frontiers in Neurology, Neurological Sciences.

ANNEXES

PUBLICATIONS

Publications on international Journal quoted in “PubMed”, National Library of Medicine (USA).

Full Papers

Raimondi L., Banchelli Soldaini G., Buffoni F., Ignesti G., Massacesi L., Amaducci L. and Friedmann C.A. (1982). Rhein and derivatives. In vitro studies on their capacity to inhibit certain proteases. Pharmacol. Res. Comm., 14(2): 103-112.
Smith M.E., Somera F.P., Saldivar R., Massacesi L. and Trotter J. (1984). DNA changes in spinal cords of rats with experimental allergic encephalomyelitis.J. Neurochem., 43: 1635-1641.
Massacesi L., Abbamondi A.L., Sarlo F. and Amaducci L. (1987). The control of experimental allergic encephalomyelitis with retinoic acid. Further studies. Riv. Neurol. 57:166-169.
Massacesi L., Abbamondi A.L., Giorgi C., Sarlo F., Lolli F. and Amaducci L. (1987). Suppression of experimental allergic encephalomyelitis by retinoic acid. J. Neurol. Sciences, 80:55-64.
Massacesi L., Abbamondi A.L., Raimondi L., Giorgi C. and Amaducci L. (1988). Lysosomal enzymes in experimental allergic encephalomyelitis: time course and evidence of the source. Neurochem. Res., 13:165-169.
Theoharides TC, Lambrachthall M, Massacesi L, et al. (1990). Reduced incidence of experimental allergic encephalomyelitis (EAE) with the tricyclic sep-ch. Europ. J. Pharmacol., 183: 626-627.
Massacesi L., Castigli E., Vergelli M., Olivotto J., Abbamondi A.L., Sarlo F. and Amaducci L. (1991). Immunosuppressive activity of 13-cis retinoic acid and prevention of experimental autoimmune encephalomyelitis in rats. J.Clin.Invest., 88:1331-1337.
Riskind P., Massacesi L., Doolittle T.H. and Hauser S.L. (1991).The role of prolactin in autoimmune demyelination: suppression of experimental allergic encephalomyelitis by bromocriptine. Ann. Neurol., 29: 542-547.
Zehetbauer B., Massacesi L., Liuzzi G. M., Vergelli M., Olivotto J., Grassi L., Riccio P. and Amaducci L. (1991). Myelin Basic Protein in lipid-bound form induces experimental allergic encephalomyelitis and demyelination in Lewis rat. Acta Neurologica 13: 121-132.
Massacesi L., Parritz D., Joshi N, Letvin N. and Hauser S.L.(1992). Experimental allergic encephalomyelitis in Cynomolgus Monkeys: quantitation of T-cell responses in peripheral blood. J.Clin. Invest., 90: 399-404.
Salvetti M and Massacesi L. (1992). Experimental allergic encephalomyelitis and multiple sclerosis: immunoregulatory mechanisms and T cell repertoires. Cell. Immunol., 142: 217-219.
Salvetti M., Buttinelli C., Massacesi L. and Wekerle H. (1993). New approaches to the study of T-cell autoimmunity in multiple sclerosis. J. Neuroimmunol., 47: 203-205.
Yu J.S., Pandey J. P., Massacesi L., Lincoln R., Usuku K., Seboun E. and Hauser S.L. (1993). Segregation of Immunoglobulin heavy Chain constant region genes in Multiple sclerosis sibling pairs. J. Neuroimmunol., 42: 113-116.
Lolli F., Liuzzi G.M., Vergelli M., Massacesi L., Ballerini C., Amaducci L. and Riccio P. (1993). Antibodies specific for the lipid-bound form of myelin basic protein during experimental autoimmune encephalomyelitis. J. Neuroimmunol., 44: 69-75
Massacesi L., Vergelli M., Zehetbauer B., Liuzzi G.M., Olivotto J., Ballerini C., Uccelli A., Mancardi L., Riccio P. amd Amaducci L. (1993). Induction of experimental autoimmune encephalomyelitis in rats and immune response to myelin basic protein in lipid bound form. J. Neurol. Sciences, 119: 91-98.
Da Vico S., Massacesi L., Amaducci L. (1993). Survey of the italian neurological output in the three years 1989-1991. It J. Neurol. Sci., 14: 595-598.
Genain C.P., Parritz D., Hoa Nguyen M., Massacesi L., Ioshi N., Ferrante R., Hoffman K., Moseley M., Levtin N., Hauser S. (1994). In healthy primates, circulating autoreactive T-cells mediate autoimmune disease. J. Clinic. Invest., 94: 1339-1345.
Vergelli M., Mazzanti B., Ballerini C., Gran B., Amaducci L. and Massacesi L. (1995). Trasforming growth factor-beta1 inhibits the proliferation of rat astrocytes induced by serum and growth factors. J. Neurosc. Res., 40: 127-133.
Massacesi L., Genain C.P., Parritz D.L., Canfield D., Letvin N. and Hauser S.L. (1995). Active and passively induced experimental autoimmune encephalomyelitis in common marmosets: a new model for multiple sclerosis. Ann. Neurol., 37: 519-530.
Hohlfeld R., Londei M., Massacesi L. and Salvetti M. (1995).T-cell autoimmunity in multiple sclerosis. Immunology Today (now Trends in Immunology), 16:259-261.
Amato M.P., Massacesi L. and Amaducci L. (1996). Clinical outcome measurements in Multiple Sclerosis trials. MS Forum. Int. MS Journal 3 n(1) : 19-27.
Vergelli M., Olivotto J., Castigli E., Gran B., Raimondi L., Pirisino R., Amaducci L. and Massacesi L. (1997). Immunosuppressive activity of 13-cis-retinoic acid in rats: Aspects of pharmacokinetics and pharmacodynamics. Immunopharmacol., 37: 191-197.
Mazzanti B. , M. Vergelli, P. Riccio, R. Martin, H.F. McFarland, G.M. Liuzzi, L. Amaducci and Massacesi L. (1998). T cell response to Myelin Basic Protein in patients with Multiple Sclerosis and healthy donors. J. Neuroimmunol., 82: 96-100.
Gran B., Gestri D., Sottini A., Quiròs Roldàn E., Bettinardi A., Signorini S., Primi D., Ballerini C., Taiuti R., Amaducci L. and Massacesi L. (1998). Detection of skewed T-cell receptor V-beta gene usage in the peripheral blood of patients with multiple sclerosis. J. Neuroimmunol., 85: 22-32.
Cascino I., Ballerini C., Audino S., Rombolà G., Massacesi L., Colombo G., Scorza Smeraldi R., D’Alfonso S., Momigliano Richiardi P., Tosi R., Ruberti G. (1998). Fas Gene Polymorphisms are not associated with Systemic Lupus Erythematosus, Multiple Sclerosis and HIV Infection. Disease Markers, 13: 221-225.
Laman J.D., van Meurs M., Schellekens M.M., de Boer M., Melchers B., Massacesi L., Lassmann H., Klaassen E., ‘t Hart B. (1998). Expression of accessory molecules and cytokines in acute EAE in marmoset monkeys (Callithrix jacchus). J. Neuroimmunol., 86: 30-45.
‘t Hart B., Bauer J., Muller H.J., Melchers B., Nicolay K., Brok H., Bontrop R., Lassmann H. and Massacesi L. (1998) Histopathological characterization of magnetic resonance imaging-decectable brain white matter lesions in a primate model of multiple sclerosis. Am. J. Pathol., 153: 649-663.
Kappos, L; Polman, C; Pozzilli, C et al (1998). Placebo-controlled multicentre randomised trial of Interferon beta-1b in treatment of secondary progressive multiple sclerosis. Lancet, 352: 1491-97.
Mazzucco S., Nardi E., Chelli M., Ginanneschi M., Rapi G., Papini A.M., Vergelli M., Mazzanti B., Massacesi L., Amaducci L. (1999). Synthesis of lipopeptides of the immunodominant epitope hMBP(83-99) containing amide or C-C bond linked hydrophobic chains for the study of T cell response. Letters in Peptide Sciences 6: 51-59.
Mazzucco S., Matà S., Vergelli M., Fioresi R., Nardi E., Mazzanti B., Chelli M., Lolli F., Ginanneschi M., Pinto F., Massacesi L. and Papini A.M. (1999). A synthetic glycopeptide of human myelin oligodendrocyte glycoprotein to detect antibody responses in multiple sclerosis and other neurological diseases. Bioorg. Med. Chem. Lett. : 167-172.
Sabbadini M.G., Manfredi AA., Bozzolo E., Ferrario L., Rugarli C., Scorza R., Origgi L., Vanoli M., Gambini O., Vanzulli L., Croce D., Campana A., Messa C., Fazio F., Tincani A., Anzola G., Cattaneo R., Padovani A., Gasparotti R., Gerli R., Quartesan R., Piccirilli M., Farsi A., Emmi E., Domeneghetti M., Piccini C., Massacesi L., Pupi A., De Cristoforis M., Danieli M., Candela M., Fraticelli P., Bartolini M., Savolini U., Danieli G. and Passaleva A. (1999). Central Nervous system involvement in Systemic Lupus Eritematosus patients without overt neuropsychiatric manifestations. Lupus 8: 11-19.
D’Alfonso S., Nisticò L., Zavattari P., Marrosu M., Murru R., Lai M., Massacesi L., Ballerini C., Gestri D., Salvetti M., Ristori G., Bomprezzi R., Trojano M., Liguori M., Gambi D., Quattrone A., Fruci D., Cucca F., Momigliano Richiardi P. and Tosi R. (1999). A linkage analysis of Multiple Sclerosis with candidate region markers in Sardinian and Continental Italian families. Eur. J Hum.Gen. 7 : 377-385.
Miller D.H., Molyneux P.D., Barker G.J., Mac Manus D.G., Moseley I.F., Wagner K.,and the European Study Group on Interferon-Beta1b in Secondary Progressive Multiple Sclerosis. (1999) Effect of Interferon-Beta1b on Magnetic Resonance Imaging Outcomes in Secondary Progressive Multiple Sclerosis: Results of a European Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial. Ann. Neurol., vol. 46, 850-859.
Ballerini C. Nacmias B., Rombolà G., Marcon G., Massacesi L., Sorbi S. (1999) HLA A2 Allele Is Associated with Age at Onset of Alzheimer’s Disease. Ann. Neurol., vol. 45: 397-400.
Mazzanti B., Hemmer B., Traggiai E., Ballerini C., McFarland H.F., Massacesi L., Martin R. and Vergelli M. (2000). Decrypting the Spectrum of Antigen-Specific T-Cell Responses: The Avidity Repertoire of MBP-Specific T-Cells. J. Neurosci. Res., 59:86-93.
‘t Hart B.A., van Meurs M., Brok H.P.M., Massacesi L., Bauer J., Boon L., Bontrop R.E and Laman J.D. (2000). A new primate model for multiple sclerosis in the common marmoset. Immunology Today (ora Trends in Immunology), 21: 290-297.
Pupi A., Sestini S., De Cristofaro M.T., Emmi L., Marchione T., Salvati G., Li Gobbi F., Massacesi L., Meldolesi U. (2000). Use of technetium-99mhexametylpropyleneamine oxime single-photon emission tomography for the study of cerebral blood flow reactivity after acetazolamide infusion in patients with Behcet’s disease. Eur. J. Nucl. Med. 27(6): 700-706.
D’Alfonso S., Nisticò L., Bocchio D., Bomprezzi R., Marrosu M.G., Murru M.R., Lai M., Massacesi L., Ballerini C., Repice A., Solvetti M., Montesperelli C., Ristori G., Trojano M., Liguori M., Gambi D., Quattrone A., Tosi R., Momigliano-Richiardi P. (2000). An attempt of identifying MS-associated loci as a follow-up of a genomic linkage study in the Italian population. J. Neurovirol. 6 (S 2):18-22.
Molyneux P.D., Kappos L., Polman C., Pozzilli C., Barkhof F., Filippi M., Yousry T., Hahn D., Wagner K., Ghazi M., Beckmann K., Dalhke F., Losseff N., Barker G.J., Thompson A.J., Miller D.H. and the European Study Group on Interferon beta-1b in Secondary Progressive Multiple Sclerosis (2000). The effect of interferon beta-1b treatment on MRI measures of cerebral atrophy in secondary progressive multiple Sclerosis. Brain 123: 2256-2263.
Ballerini C., Campani D., Rombolà G., Gran B., Nacmias B., Amato M.P., Siracusa G., Bartolozzi L., Sorbi S. and Massacesi L. (2000). Association of apolipoprotein E polymophism to clinical heterogeneity of multiple sclerosis. Neurosci. Lett. 296: 174-176.
Papini AM, Mulinacci B, Carotenuto A, Bonetti B, Sabatino G, Peron E, Nuti F, Alcaro MC Pozo-Carrero MC, Mazzanti, B, Pazzagli m, Massacesi L, Battistini L, Chelli, M, Rovero, P, Lolli, F, Chorev M, Sawyer, TK, 2001. MS PepKit: The first diagnostic test to follow-up multiple sclerosis. Peptide Revolution: Genomics, Proteomics & Therapeutics
Chiarugi A., Cozzi A., Ballerini C., Massacesi L. and Moroni F. (2001). Kynurenine 3-monoxygenase activity and neurotoxic kynurenine metabolites increase in the spinal cord of rats with experimental allergic encephalomyelitis. Neuroscience 102: 687 - 695.
Mancardi G., t’Hart B., Roccatagliata L., Brok H., Giunti D., Bontrop R., Massacesi L., Capello E. and Uccelli A. (2001.) Demyelination and axonal damage in a non-human primate model of multiple sclerosis. J. Neurol. Sciences 184: 41-49.
Gestri D., Baldacci L., Taiuti R., Galli E., Maggi E., Piccinni M.P., Vergelli M. and Massacesi L. (2001). Oligoclonal T-cell repertoire in cerebrospinal fluid of patients with nervous system inflammatory diseases. J. Neurol. Neurosurg. Psych. 70: 767- 772.
Broadley S., Sawcer S., D'Alfonso S., Henseik A., Coraddu F., Gray J., Roxburgh R., Clayton D., Buttinelli C., Quattrone A, Trojano M., Momigliano Richiardi P. , Massacesi L. and Compston A. (2001). A genome screen for multiple sclerosis in Italian families. Genes Immun. 2: 205-10.
Mancardi G.L., Saccardi, R., Filippi, M., Gualandi F., Murialdo A., Inglese M., Marrosu M.G., Meucci G., Massacesi L., Lugaresi A., Pagliai F., Sormani M.P., Sardanelli F., Marmont A. and the Italian Gitmo-Neuro Intergroup on Autologous Hematopoietic Stem Cell Transplantation for Multiple Sclerosis (2001). Autologous hematopoietic stem cell transplantation suppresses Gadolinium-enhanced MRI activity in multiple sclerosis. Neurology 57:62-68.
Papini A.M., Mazzanti B., Nardi E., Traggiai E., Ballerini C., Biagioli T., Kalbacher H., Beck H., Deeg M., Chelli M., Ginanneschi M., Massacesi L., Vergelli M. (2001). Palmitoyl Derivatives of GpMBP Epitopes: T-Cell Response and Peptidases Susceptibility. J. Med. Chem 44: 3504- 3510.
Soldan S. S., Fogdell-Hahn A., Brennan M. B., Mittleman B. B., Ballerini C., Massacesi L., Seya T., McFarland H. F. and Jacobson S. (2001). Elevated serum and CSF levels of soluble HHV-6 cellular receptor, membrane cofactor protein (MCP; CD46), in patients with multiple sclerosis. Ann. Neurol. 50: 486-93.
Vergelli M., B. Mazzanti, E. Traggiai, T. Biagioli, C. Ballerini, A Parigi, G. Pellicanò, A. Konze, Massacesi L (2001). Short-term evolution of autoreactive T-cell repertoire in multiple sclerosis. J Neurosci Res. 66:517-24.
Traggiai E., Biagioli T., Rosati E., Ballerini C., Mazzanti B., Ben Nun A., Massacesi L., Vergelli M. (2001). IL-7-enhanced T-cell response to myelin proteins in multiple sclerosis. J. Neuroimmunol. 121:111-9.
Kappos L., Polman C., Pozzilli C., Thompson A., Beckmann K., Dalhke F., and the European Study Group on Interferon beta-1b in Secondary Progressive Multiple Sclerosis (2001). Final analysis of the European multicenter trial on IFNbeta-1b secondary progressive Multiple Sclerosis. Neurology 57: 1969-1975.
Freeman J, Thompson A., Fitzpatrick R., Hutchinson M., Miltenburger C., Beckmann K., Kappos L., Dalhke F., Polman C., Pozzilli C., and the European Study Group on Interferon beta-1b in Secondary Progressive Multiple Sclerosis (2001). IFNbeta-1b in the treatment of secondary progressive Multiple Sclerosis. Impact on quality of life. Neurology 57: 1870-1875.
Molyneux PD, Barker GJ, Barkhof F, Beckmann K, Dahlke F, Filippi M, Ghazi M, Hahn D, MacManus D, Polman C, Pozzilli C, Kappos L, Thompson AJ, Wagner K, Yousry T, Miller DH; European Study Group on Interferon Beta-1b in Secondary Progressive MS (2001). Clinical-MRI correlations in a European trial of interferon beta-1b in secondary progressive MS.Neurology 57: 2191-7.
D'Alfonso S., Mellai M., Giordano M., Pastore A., Malferrari G., Naldi P., Repice A., Liguori M., Cannoni S., Milanese C., Caputo D., Savettieri G., Momigliano-Richiardi P. and the Italian Group for the Study of Multiple Sclerosis Genetics(2002). Identification of single nucleotide variations in the coding and regulatory regions of the myelin-associated glycoprotein gene (MAG) and study of their association with multiple sclerosis. J. Neuroimmunol. 126 : 196-204.
Muraro, P.A., Bonanni, L., Mazzanti B., Pantalone, A., Traggiai, E., Massacesi L., Vergelli, M., Gambi, D. (2002). Short-term dynamics of circulating T cell receptor V beta repertoire in relapsing-remitting MS. J. Neuroimmunol. 127: 149-59.
Massacesi L. (2002). Compartmentalization of the immune response in the central nervous system and natural history of multiple sclerosis. Implications for therapy. Clin Neurol Neurosurg 104: 177-81.
Ballerini C., Rosati E., Salvetti M., Ristori G., Cannoni S., Biagioli T., Massacesi L., Sorbi S., Vergelli M. (2002). PTPRC exon 4 gene mutation distribution in a Italian MS population. Neuroscience Letters 328: 325-7.
Buzzetti R., Pozzilli P., Di Mario U., Ballerini C., and Massacesi L. (2002). Multiple sclerosis and Type I diabetes. Diabetologia 45: 1735-6.
Mellai M., Giordano M., D’Alfonso S., Marchini M., Scorza R., Danieli M.G., Leone M., Ferro I., Liguori M., Trojano M., Ballerini C., Massacesi L., Cannoni S., Bomprezzi R., Momigliano-Richiardi P. (2003). Prolactin and prolactin receptor gene polymorphisms in multiple sclerosis and systemic lupus erythematosus. Human Immunol. 64: 274-284.
Polman C, Kappos L, White R, Dahlke F, Beckmann K, Pozzilli C, Thompson A, Petkau J, Miller D; European Study Group in Interferon Beta-1b in Secondary Progressive MS (2003). Neutralizing antibodies during treatment of secondary progressive MS with interferon beta-1b. Neurology 60: 37-43.
Sormani MP, Bruzzi P, Beckmann K, Wagner K, Miller DH, Kappos L, Filippi M; European Study Group on Interferon Beta-1b in Secondary Progressive MS (2003). MRI metrics as surrogate endpoints for EDSS progression in SPMS patients treated with IFN beta-1b. Neurology 60: 1462-6.
Alizadeh M, Babron MC, Birebent B, Matsuda F, Quelvennec E, Liblau R, Cournu-Rebeix I, Momigliano-Richiardi P, Sequeiros J, Yaouanq J, Genin E, Vasilescu A, Bougerie H, Trojano M, Martins Silva B, Maciel P, Clerget-Darpoux F, Clanet M, Edan G, Fontaine B, Semana G. (2003) and the Portuguese and Italian Group for MS genetics. Genetic interaction of CTLA-4 with HLA-DR15 in multiple sclerosis patients. Ann Neurol. 54:119-22.
Akesson E, Coraddu F, Marrosu MG, Massacesi L, Hensiek A, Harbo HF, Oturai A, Trojano M, Momigliano-Richiardi P, Cocco E, Murru R, Hillert J, Compston A and Sawcer S (2003). Refining the linkage analysis on chromosome 10 in 449 sib-pairs with multiple sclerosis. J Neuroimmunol.143: 31- 38.
Liguori M, Sawcer S, Setakis E, Compston A, Giordano M, D'Alfonso S, Mellai M, Malferrari G, Trojano M, Livrea P, De Robertis F, Massacesi L, Repice A, Ballerini C, Biagioli T, Bomprezzi R, Cannoni S, Ristori G, Salvetti M, Grimaldi LM, Biunno I, Comi G, Leone M, Ferro I, Naldi P, Milanese C, Gellera C, Loredana LM, Savettieri G, Salemi G, Aridon P, Caputo D, Rosa Guerini F, Ferrante P, and Momigliano-Richiardi P (2003). A whole genome screen for linkage disequilibrium in multiple sclerosis performed in a continental Italian population. J Neuroimmunol. 143: 97-100.
Ballerini C, Guerini F, Rombolà G, Rosati E, Massacesi L, Ferrante P, Caputo D, Figà Talamanca L, Naldi P, Liguori M, Alizadeh M, Momigliano-Richiardi P, D’Alfonso S (2004). HLA-Multiple Sclerosis association in Continental Italy and correlation with disease prevalence in Europe. J Neuroimmunol. 150:178 -85.
IngleseM, G L Mancardi, E Pagani, M A Rocca, A Murialdo, R Saccardi, G Comiand M Filippi the Italian GITMO-NEURO Intergroup on Autologous Hemotopoietic Stem Cell Transplantation (2004).Brain tissue loss occurs after suppression of enhancement in patients with multiple sclerosis treated with autologous haematopoietic stem cell transplantation. J. Neurol. Neurosurg. Psych. 75: 643-644.
Saccardi R, Mancardi GL, Solari A, Bosi A, Bruzzi P, Di Bartolomeo P, Donelli A, Filippi M, Guerrasio A, Gualandi F, La Nasa G, Murialdo A, Pagliai F, Papineschi F, Scappini B, Marmont AM. and the Italian GITMO-NEURO Intergroup on Autologous Hemotopoietic Stem Cell Transplantation (2005). Autologous HSCT for severe progressive multiple sclerosis in a multicenter trial: impact on disease activity and quality of life. Blood. 105:2601-7.
MazzantiB, Biagioli T., Aldinucci A., Cavaletti G., CavalettiE., Crippa L., Oggioni N.,Sala F., Sala V., Frigo M., Rota S., Tagliabue E., Ballerini C., Massacesi L., Riccio P. and Lolli F. (2005). Effects of Pixantrone on T- and B-cell function in the course of acute rat experimental allergic encephalomyelitis. J. Neuroimmunol. 168: 111-117.
Capello E, Saccardi R, Murialdo A, Gualandi F, Pagliai F, Bacigalupo A, Marmont A, Uccelli A, Inglese M, Bruzzi P, Sormani MP, Cocco E, Meucci G, Massacesi L, Bertolotto A, Lugaresi A, Merelli E, Solari A, Filippi M, Mancardi GL; Italian GITMO-Neuro Intergroup on ASCT for Multiple Sclerosis (2005). Intense immunosuppression followed by autologous stem cell transplantation in severe multiple sclerosis. Neurol Sci. 26: S200-3.
Massacesi L, Parigi A, Barilaro A, Repice AM, Pellicanò G, Konze A, Siracusa GF, Taiuti R and Amaducci L. (2005). Efficacy of Azathioprine on Multiple Sclerosis new brain lesions evaluated by Magnetic Resonance Imaging. Arch.Neurol.;62:1843-1847
Ristori G, Cannoni S, Stazi MA, Vanacore N, Cotichini R, Alfo M, Pugliatti M, Sotgiu S, Solaro C, Bomprezzi R, Di Giovanni S, Figa Talamanca L, Nistico L, Fagnani C, Neale MC, Cascino I, Giorgi G, Battaglia MA, Buttinelli C, Tosi R, Salvetti M. and the Italian MS genetic collaborative group (2006). Multiple sclerosis in twins from continental Italy and Sardinia: A nationwide study. Ann Neurol.59(1):27-34.
The GAMES Collaborative Group, Ban M, Booth D, Heard R, Stewart G, Goris A, Vandenbroeck K, Dubois B, Laaksonen M, Ilonen J, Alizadeh M, Edan G, Babron MC, Brassat D, Clanet M, Cournu-Rebeix I, Fontaine B, Semana G, Goedde R, Epplen J, Weber A, Infante-Duarte C, Zipp F, Rajda C, Bencsik K, Vécsei L, Heggarty S, Graham C, Hawkins S, Liguori M, Momigliano-Richiardi P, Caputo D, Grimaldi LM, Leone M, Massacesi L, Milanese C, Salvetti M, Savettieri G, Trojano M, Bielecki B, Mycko MP, Selmaj K, Santos M, Maciel P, Pereira C, Silva A, Silva BM, Coraddu F, Marrosu MG, Akesson E, Hillert J, Datta P, Oturai A, Harbo HF, Spurkland A, Goertsches R, Villoslada P, Eraksoy M, Hensiek A, Compston A, Setakis E, Gray J, Yeo TW, Sawcer S. (2006). Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans. J. Neuroimmunol.179: 108-116.
Saccardi R, Kozak T, Bocelli-Tyndall C, Fassas A, Kazis A, Havrdova E, Carreras E, Saiz A, Löwenberg B, te Boekhorst P, GualandiF, Openshaw H, Longo G, Pagliai F, Massacesi L, Deconink E, Ouyang J, Zuazu Nagore F, Besalduch J, Lisukov I, Bonini A, Merelli E,Slavin S, Gratwohl A, Passweg J, Tyndall A, Steck A, Andolina M, Capobianco M, Diez Martin J, Lugaresi A,Meucci G, Sáez R,Clark R, Fernandez M, Fouillard L, Herstenstein B, Koza V, Cocco E, Baurmann H and Mancardi G on behalf of the Autoimmune Disease Working Party of EBMT (2006). Autologous stem cell transplantation for progressive multiple sclerosis: update of the European group for blood and marrow transplantation auto-immune diseases working party database. Mult. Sclerosis J 12: 814-823.
Roccatagliata L, Rocca M, Valsasina P, Bonzano L, Sormani M, Saccardi R, Mancardi G, Filippi M; for the Italian GITMO-NEURO Intergroup on Autologous Stem Cell Transplantation. (2007). The long-term effect of AHSCT on MRI measures of MS evolution: a five-year follow-up study. Mult Sclerosis. 13: 1068-70.
Aldinucci A., Gerlini G., Fossati S., Cipriani G., Ballerini C., Biagioli T., Pimpinelli N., Borgognoni L., Massacesi L., Moroni F. and Chiarugi A. (2007). Requirement for PARP-1 activity during human dendritic cell maturation. J. Immunol. 179: 305-12.
D’Alfonso S., Bolognesi E., Guerini F., Barizzone N., Bocca S., Castelli L., Bergamaschi L., Agliardi C., Ferrante P., Naldi P., Leone M., Caputo D., Ballerini C., Salvetti M., Galimberti D., Massacesi L., Trojano M., Momigliano-Richiardi P. (2008). A sequence variation in the MOG gene is involved in Multiple Sclerosis susceptibility in Italy. Genes and Immun 9: 7-15.
Luccarini I., Ballerini C., Biagioli T., Biamonte F., Bellucci A., Rosi M.C., Grossi C., Massacesi L. and Casamenti F. (2008). Combined treatment with atorvastatin and minocycline suppresses severity of EAE. Exp. Neurol., 211: 214.
Mazzanti B., Aldinucci A., Biagioli T., Barilaro A., Urbani S., Dal Pozzo S., Amato MP, Siracusa GF., Crescioli C., Manuelli A., Bosi A., Saccardi R., Massacesi L. and Ballerini C. (2008). Differences in mesenchymal stem cell cytokine profiles between MS patients and healthy donors: Implication for assessment of disease activity and treatment. J. Neuroimmunol. 199:142-50.
’t Hart B. and Massacesi L(2009). Clinical, pathological and immunological aspects of the multiple sclerosis model in common marmosets (Callithrix jacchus). J. Neuropath.Exp.Neurol. 68 (4): 341-355.
Bizzoco E, Lolli F, Repice A, Falcini M, Taiuti R, Siracusa GF, Amato MP, Biagioli T, Lori S, Moretti M, Vinattieri A, Nencini P, Massacesi L, Matà S. (2009). Prevalence of Neuromyelitis Optica Spectrum Disorder and Phenotype Distribution. J. Neurol. 256:1891-8
Aldinucci A, Biagioli T, Manuelli C, Repice A, Massacesi L, Ballerini C. (2010). Modulating dendritic cells (DC) from immunogenic to tolerogenic responses: a novel mechanism of AZA/6-MP. J. Neuroimmunol, 218:28-35.
Aldinucci A, Rizzetto L, Pieri L, Nosi D, Romagnoli P, Biagioli T, Mazzanti B, Saccardi R, Beltrame L, Massacesi L, Cavalieri D, Ballerini C (2010). Inhibition of Immune Synapse by Altered Dendritic Cell Actin Distribution: A New Pathway of Mesenchymal Stem Cell Immune Regulation. J. Immunol. 185:5102-10.
Gaitán M, SheaC, Evangelou I, Stone R, Fenton K, Bielekova B, Massacesi L, Reich D. (2011). Evolution of the Blood-Brain Barrier in Newly Forming Multiple Sclerosis Lesions. Ann. Neurol. 70: 22-29.
Gaitán M; Shea C; Evangelou I; Stone R; Fenton K; Bielekova B; Massacesi L; Reich D. (2011). Reply. Ann. Neurol., 70: 669-670.
Snowden JA, Saccardi R, Allez M, Ardizzone S, Arnold R, Cervera R, Denton C, Hawkey C, Labopin M, Mancardi G, Martin R, Moore JJ, Passweg J, Peters C, RabusinM, RoviraM, van Laar JM & Farge D on behalf of the EBMT Autoimmune Disease, (2011). Haematopietic stem cells transplantation (HSCT) in severe autoimmune diseases: updated guidelines of the European group for bone marrow transplantation (EBMT). Bone marrow Transplantation
MancardiG, Sormani M, Di Gioia M, Vuolo L, Gualandi F, Amato M, Capello E, Currò D, Uccelli A, Bertolotto A, Gasperini C, Lugaresi A, Merelli E, Meucci G, Motti L, Tola M, Scarpini E, Repice A, Massacesi L, Saccardi R. (2012) Autologous haematopoietic stem cell transplantation with an intermediate intensity conditioning regimen in multiple sclerosis: the Italian multi-centre experience. Mult Scler. J. 18: 835-842.
Lutterotti A, Jelcic I, Schulze C, Schippling S, Breiden P, Mazzanti B, Reinhard S, DiGioia M, Repice A, Massacesi L, Sputtek A, Salinas-Riester G, Kroeger N, Sospedra M, Saccardi R, Zander A and Martin R (2012). Gene expression and epigenetic profiling of CD34+ hematopoietic progenitor cells in multiple sclerosis patients – absence of proinflammatory signatures.Mult Scler. .
Saccardi R, Freedman MS, Sormani MP, Atkins H, Farge D, Griffith LM, Kraft G, Mancardi GL, Nash R, Pasquini M, Martin R, Muraro PA; European Blood and Marrow Transplantation Group; Center for International Blood and Marrow Research; HSCT in MS International Study Group (2012). A prospective, randomized, controlled trial of autologous haematopoietic stem cell transplantation for aggressive multiple sclerosis: a position paper. Mult Scler. Jun;18(6):825-34.
Zamboni P, Bertolotto A, Boldrini P, Cenni P, D'Alessandro R, D'Amico R, Del Sette M, Galeotti R, Galimberti S, Liberati A, Massacesi L, Papini D, Salvi F, Simi S, Stella A, Tesio L, Valsecchi MG, Filippini G. (2012). Efficacy and safety of venous angioplasty of the extracranial veins for multiple sclerosis. Brave Dreams Study (Brain Venous Drainage Exploited Against Multiple Sclerosis): study protocol for a randomized controlled trial. Trials 13: 183-196.
Carrai V, Donnini I, Mazzanti B, Alterini R, Amato MP, Barilaro A, Bosi A, Massacesi L, Portaccio E, Repice AM, Rotunno G and Saccardi R. (2013).Immunohistochemistry analysis of bone marrow biopsies in multiple sclerosis patients undergoing autologous hematopoietic stem cells transplantarion. Clin. Neurol. and Neurosurg. 115: 1044 – 1048
Aldinucci A, Turco A, Biagioli T, Toma F, Bani D, Guasti D, Manuelli C, Rizzetto L, Cavalieri D, Massacesi L, Mello T, Scaini D, Bianco A, Ballerini L, Prato M, Ballerini C (2013). Carbon nanotube scaffolds instruct human dendritic cells: modulating immune responses by contacts at the nanoscale. Nano Letters 13(12):6098-105.
Paganini M, Biggeri A, Romoli AM, Mechi C, Ghelli E, Berti V, Pradella S, Bucciantini S, Catelan D, Saccardi R, Lombardini L, Mascalchi M, Massacesi L, Porfirio B, Di Lorenzo N, Vannelli GB, Gallina P (2014). Foetal striatal grafting slows motor and cognitive decline of Huntington’s disease. J.Neurol.Neurosurg.Psich. 85: 974-981.
Mascalchi M, Ginestroni A, Toschi N, Poggesi A, Cecchi P, Salvadori E,Tessa C, Cosottini M,De Stefano N, Pracucci G,Pantoni L, Inzitari D, Diciotti S and VMCI Tuscany investigators. (2014).The burden of microstructural damage modulates cortical activation in elderly subjects with MCI and leuko-araiosis. A DTI and fMRI study. Human Brain Mapping35: 819–830.
Gaitan M, Maggi P, Wholer N, Leibowitch M, Sati P, Calandri B, Merkle L, Massacesi L, Silva A, Jacobson S, Rech D. (2014) Perivenular Brain lesions in a primate multiple sclerosis model at 7-tesla MRI. Mult. Scler. 20(1):64–71.
Maggi P, Cummings Macri S, Gaitán M, Leibovitch E, Wohler J, Knight H, Ellis M, Wu T, Silva A, Massacesi L, Jacobson S, Westmoreland S, Reich D (2014). The formation of inflammatory demyelinated lesions in cerebral white matter. Ann. Neurol. 76:594-608.
Massacesi L, Tramacere I, Amoroso S, Battaglia M, Benedetti MD, Filippini G, La Mantia L, Repice A M, Solari A, Tedeschi G, Milanese C (2014). Azathioprine versus Beta Interferons for relapsing-remitting multiple sclerosis: a multicentre randomized non-inferiority trial. PlosOne, 9(11):e113371; e-Pub, November 17 2014.
Bonechi E, Aldinucci A, Mazzanti B., DiGioia M, Repice A, Manuelli C, Saccardi R, Massacesi L, Ballerini C, (2014). Increased CXCL10 expression in Multiple Sclerosis MSCs and monocytes is unaffected by AHSCT. Ann Clin Transl Neurol, 1:650-8.
Laroni A, Brogi D, Morra VB, Guidi L, Pozzilli C, Comi G, Lugaresi A, Turrini R, Raimondi D, Uccelli A, Mancardi GL, EAP Investigators (2014). Safety of the first dose of fingolimod for multiple sclerosis: results of an open-label clinical trial. BMC Neurol. 14:65.
Gallina P, Paganini M, Lombardini L, Biggeri A, Marini M, Morelli AM, Bucciantini S, Sarchielli E, Ambrosini S, Mechi C, Romoli AM, Ghelli E, Pradella S, Urbani S, Mazzanti B, Berti V, Giordano GP, Campolo M, Dal Pozzo S, Piacentini S, Saccardi R, Massacesi L, Mascalchi M, Bosi A, Conti R, Porfirio B, Di Lorenzo N, Vannelli GB,(2014). Trapianto intracerebrale di striato fetale nella malattia di Huntington: un aggiornamento dell'esperienza clinica italiana. Trapianti 18: 5-11.
Salvadori E, Poggesi A, Valenti R, Pracucci G, Pescini F, Pasi M, Nannucci S, Marini S, Del Bene A, Ciolli L, Ginestroni A, Diciotti S, Orlandi G, Di Donato I, De Stefano N, Cosottini M, Chiti A, Federico A, Dotti MT, Bonuccelli U, Inzitari D, Pantoni L and the VMCI-Tuscany Study Group(2015). Development and psychometric properties of a neuropsychological battery for mild cognitive impairment with small vessel disease: the VMCI-Tuscany Study. J Alzheimers Dis. 43: 1313-23.
Maggi P, Mazzoni L, Moretti M, MassacesiL (2015). SWI enhances vein detection usung gadolinium in multiple sclerosis. Acta Radiologica Open. 4:2047981614560938.
Clausi V, Giannecchini S,Magnani E, Repice A, Mechi C, Martelli F, Azzi A, Massacesi L. (2015).Markers of JC Virus Infection in Multiple Sclerosis Patients Under Natalizumab Therapy. Neurology Neuroimmunol Neuroinflamm. 2: e58.
Mancardi GL, Sormani MP, Gualandi F, Saiz A, Carreras E, Merelli E, Donelli A, Lugaresi A, Di Bartolomeo P, Rottoli MR, Rambaldi A, Amato MP, Massacesi L, Di Gioia M, Vuolo V, Currò D, Roccatagliata L, Filippi M, Aguglia U, Iacopino P, Farge D, and Saccardi R. (2015). Autologous Haematopoietic Stem Cell Transplantation in Multiple Sclerosis: a phase II trial. Neurology. 84:981-8.
Giovannelli I, Martelli F, Repice AM, Massacesi L, Azzi A and Giannecchini S (2015). Detection of JCPyV microRNA in Blood and urine samples of multiple sclerosis patients under natalizumab therapy. J. of Neurovirology, 21: 666-70.
Capobianco M, Lo Re M, Sangalli F, Moiola L, Perini P, Gallo P, Danni M, Provinciali L, Repice AM, Massacesi L, Messina S, Patti F, Laroni A, Mancardi GL, Pucci E, Calabrese M and Bertolotto A (2015). Cyclophosphamide Pulse Therapy after Natalizumab Discontinuation for Multiple Sclerosis: a multicenter study. J Mult Scler (Foster City) 2:151.
Maggi P, Sati P, Massacesi L. (2016). Magnetic resonance imaging of experimental autoimmune encephalomyelitis in the common marmoset. J Neuroimmunol. 304:86-92.
Lagi F, Bartalesi F, Pecile P, Biagioli T, Caldini AL, Fanelli A, Giannazzo G, Grifoni S, Massacesi L, Bartoloni A, Rossolini GM. (2016). Proposal for a New Score-Based Approach To Improve Efficiency of Diagnostic Laboratory Workflow for Acute Bacterial Meningitis in Adults. J Clin Microbiol. 54:1851-4.
Montanari E, Rottoli M, Maimone D, Confalonieri P, Plewnia K, Frigo M, Francia A, Pala A, Losignore NA, Ragonese P, Veneziano A; POSIDONIA study group. (2016). A 12-month prospective, observational study evaluating the impact of disease-modifying treatment on emotional burden in recently-diagnosed multiple sclerosis patients: The POSIDONIA study. J Neurol Sci. 15;364:105-9.
Salvadori E, Poggesi A, Valenti R, Pracucci G, Pescini F, Pasi M, Nannucci S, Marini S, Del Bene A, Ciolli L, Ginestroni A, Diciotti S, Orlandi G, Di Donato I, De Stefano N, Cosottini M, Chiti A, Federico A, Dotti MT, Bonuccelli U, Inzitari D, Pantoni L; VMCI-Tuscany Study Group (2016). Operationalizing mild cognitive impairment criteria in small vessel disease: the VMCI-Tuscany Study. Alzheimers Dement. 2016 Apr;12(4):407-18.
Sati P, Oh J, Constable RT, Evangelou N, Guttmann CR, Henry RG, Klawiter EC, Mainero C, Massacesi L, McFarland H, Nelson F, Ontaneda D, Rauscher A, Rooney WD, Samaraweera AP, Shinohara RT, Sobel RA, Solomon AJ, Treaba CA, Wuerfel J, Zivadinov R, Sicotte NL, Pelletier D, Reich DS; NAIMS Cooperative (2016).The central vein sign and its clinical evaluation for the diagnosis of multiple sclerosis: a consensus statement from the North American Imaging in Multiple Sclerosis Cooperative. Nat Rev Neurol. 12:714-722.
Cadavid D, Balcer L, Galetta S, Aktas O, Ziemssen T, Vanopdenbosch L, Frederiksen J, Skeen M, Jaffe GJ, Butzkueven H, Ziemssen F, Massacesi L, Chai Y, Xu L, Freeman S; RENEW Study Investigators (2017). Safety and efficacy of opicinumab in acute optic neuritis (RENEW): a randomised, placebo-controlled, phase 2 trial. Lancet Neurol. 16:189-199.
Muraro P, Pasquini M, Atkins HL, Bowen JD, Farge D, Fassas A, Freedman MS, Georges GE, Gualandi F, Hamerschlak N, Havrdova E, Kimiskidis VK, Kozak T, Mancardi GL, Massacesi L, Moraes DA, Nash RA, Pavletic S, Ouyang J, Rovira M, Saiz A, Simoes B, Trnený M, Zhu L, Badoglio M, Zhong X, Sormani MP, Saccardi R. Multiple Sclerosis–Autologous Hematopoietic Stem Cell Transplantation (MS-AHSCT) Long-term Outcomes Study Group (2017). Long-term Outcomes After Autologous Hematopoietic Stem Cell Transplantation for Multiple Sclerosis. JAMA Neurol. 74:459-469.
Forci B, Mariottini A, Mechi C, Massacesi L, Repice A. (2017).Disease reactivation following fingolimod withdrawal in multiple sclerosis: Two case reports. Mult Scler Relat Disord. 2017 Jul;15:24-26.
ZamboniP, TesioL, GalimbertiS, Massacesi L, SalviF, D’AlessandroR, CenniP, GaleottiR, PapiniD,D’AmicoR, SimiS, ValsecchiMG, FilippiniG and the Brave Dreams Research Group (2018). Efficacy and safety of extracranial vein angioplasty in multiple sclerosis: a randomized clinical trial. JAMA Neurol., 75:35-43.
Maggi P, Absinta M, GrammaticoM, Vuolo L, EmmiG, Carlucci G, Spagni G, Barilaro A, Repice AM, Emmi L, Prisco D, Martinelli V, Scotti R, Sadeghi N, Perrotta G, Sati P, Dachy B, Reich DS, Filippi M, Massacesi L. (2018). The central vein sign differentiates multiple sclerosis from CNS inflammatory vasculopathies. Ann Neurol, 83:283-294.
Kapoor R, Ho PR, Campbell N, Chang I, Deykin A, Forrestal F, Lucas N, Yu B, Arnold DL, Freedman MS, Goldman MD, Hartung HP, Havrdová EK, Jeffery D, Miller A, Sellebjerg F, Cadavid D, Mikol D, Steiner D; ASCEND investigators (2018) Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND): a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension. Lancet Neurol. 17:405-415.
Cadavid D, Balcer L, Galetta S, Aktas O, Ziemssen T, Vanopdenbosch LJ, Leocani L, Freedman MS, Plant GT, Preiningerova JL, Ziemssen F, Massacesi L, Chai Y, Xu L; RENEW Study Investigators. (2018). Predictors of response to opicinumab in acute optic neuritis. Annals of Clinical and Translational Neurology.15;5(10):1154-1162.
D'Amore A, Tessa A, Casali C, Dotti MT, Filla A, Silvestri G, Antenora A, Astrea G, Barghigiani M, Battini R, Battisti C, Bruno I, Cereda C, Dato C, Di Iorio G, Donadio V, Felicori M, Fini N, Fiorillo C, Gallone S, Gemignani F, Gigli GL, Graziano C, Guerrini R, Gurrieri F, Kariminejad A, Lieto M, Marques LourenḈo C, Malandrini A, Mandich P, Marcotulli C, Mari F, Massacesi L, Melone MAB, Mignarri A, Milone R, Musumeci O, Pegoraro E, Perna A, Petrucci A, Pini A, Pochiero F, Pons MR, Ricca I, Rossi S, Seri M, Stanzial F, Tinelli F, Toscano A, Valente M, Federico A, Rubegni A, Santorelli FM. (2018). Next Generation Molecular Diagnosis of Hereditary Spastic Paraplegias: An Italian Cross-Sectional Study.Front Neurol. 9:981.
Trojano M, Bergamaschi R, Amato MP, Comi G, Ghezzi A, Lepore V, Marrosu MG, Mosconi P, Patti F, Ponzio M, Zaratin P, Battaglia MA^,(2018). Italian Multiple Sclerosis Register Centers Group. The Italian multiple sclerosis register. Neurol Sci. 40(1):155-165.
Mariottini A, Innocenti C, Forci B, Magnani E, Mechi C, Barilaro A, Nistri R, Fani A, Saccardi R, Massacesi L, Repice AM (2019). Safety and efficacy of autologous hematopoietic stem cell transplantation following natalizumab discontinuation in aggressive Multiple Sclerosis. Eur J Neurol. 26(4):624-630
Maggi P, Absinta M, Sati P, Perrotta G, Massacesi L, Dachy B, Pot C, Meuli R, Reich DS, Filippi M, Pasquier RD, Théaudin M (2019). The "central vein sign" in patients with diagnostic "red flags" for multiple sclerosis: A prospective multicenter 3T study. Mult Scler J.
Pasca M, Picchioni A, Mazzeo S, Terenzi F, Prestipino E, Fratangelo R, Repice AM,Carlucci G, Massacesi L, Barilaro A (2019). A Case of Recurrent Progressive Multifocal Leukoencephalopathy After Human Stem Cell Transplant, With Detection of John Cunningham Virus and Human Herpesvirus 6 on Cerebrospinal Fluid, Treated With Mirtazapine, Olanzapine and Foscarnet. Intractable Rare Dis Res 8, 275-278.
Gastaldi M, Mariotto S, Giannoccaro MP, Iorio R, Zoccarato M, Nosadini M, Benedetti L, Casagrande S, Di Filippo M, Valeriani M, Ricci S, Bova S, Arbasino C, Mauri M, Versino M, Vigevano F, Papetti L, Romoli M, Lapucci C, Massa F, Sartori S, Zuliani L, Barilaro A, De Gaspari P, Spagni G, Evoli A, Liguori R, Ferrari S, Marchioni E, Giometto B, Massacesi L, Franciotta D(2020). Subgroup Comparison According to Clinical Phenotype and Serostatus in Autoimmune Encephalitis: A Multicenter Retrospective Study. Eur J Neurol. 27(4):633-643.
Mariottini A, Filippini S, Innocenti C, Forci B, Mechi C, Barilaro A, Fani A, Carlucci G, Saccardi R, Massacesi L, Repice AM, 2020. Impact of autologous haematopoietic stem cell transplantation on disability and brain atrophy in secondary progressive multiple sclerosis Mult Scler 2020 Feb 3;
Berardelli A, Silani V, Barone P, Calabresi P, Girlanda P, Lopiano L, Massacesi L, Monaco S, Onofrj M, Tassorelli C, Tedeschi G. (2020). Neurology and the COVID-19 emergency. Neurol Sci. 41:1343-1344
Piccini B, M, Amato MP, Bartalini S, Falcini M, Giannini M, Magnani E, Massacesi L, Repice AM, Vascotto M, Grosso S.. (2020). Association of celiac disease in patients with multiple sclerosis in Tuscany.Rev Esp Enferm Dig. 112:474-476.
Amoriello R, Greiff V, Aldinucci A, Bonechi E, Carnasciali A, Peruzzi B, Repice AM, Mariottini A, Saccardi R, Mazzanti B, Massacesi L, Ballerini C. (2020).The TCR Repertoire Reconstitution in Multiple Sclerosis: Comparing One-Shot and Continuous Immunosuppressive Therapies. Front Immunol. 11:559.
Steingo B, Al Malik Y, Bass AD, Berkovich R, Carraro M, Fernández Ó, Ionete C, Massacesi L, Meuth SG, Mitsikostas DD, Pardo G, Simm RF, Traboulsee A, Choudhry Z, Daizadeh N, Compston DAS CAMMS223, CAMMS03409, and TOPAZ Investigators. (2020). Long-term efficacy and safety of alemtuzumab in patients with RRMS: 12-year follow-up of CAMMS223.J Neurol. Jun 24. E-pub.
Berardelli A, Silani V, Barone P, Calabresi P, Girlanda P, Lopiano L, Massacesi L, Monaco S, Onofrj M, Tassorelli C, Tedeschi G., 2020. Neurology and the COVID-19 emergency.Neurol Sci. 41:1343-1344.
Signori A, Boffa G, Bovis F, Mariottini A, Repice AM, Inglese M, Amato MP, Mancardi GL, Massacesi L, Saccardi R and Sormani MP (2021). Prevalence of disability improvement as a potential outcome for multiple sclerosis trials. Multiple Sclerosis J., 27:706-711.
Lepore V, Bosetti C, Santucci C, Iaffaldano P, Trojano M, Mosconi P and the Italian Multiple Sclerosis Register Centers Group, the Scientific Committee of Italian SM Register. (2021). Detection of disability worsening in relapsing-remitting multiple sclerosis patients: a real-world roving Expanded Disability Status Scale reference analysis from the Italian Multiple Sclerosis Register. Eur J Neurol., 28567-578
Pasca M, Forci B, Mariottini A, Mechi C, Barilaro A, Massacesi L, Repice AM. (2021). Sustained disease remission after discontinuation of disease-modifying treatments in relapsing-remitting multiple sclerosis. Mult. Scler. Rel. Dis. 47: 102591. Online ahead of print.
Boffa, Massacesi L. Inglese M, Mariottini A, Capobianco M, Moiola L, Amato MP, Cottone S, Gualandi F, De Gobbi M, Greco R, Scime R, Frau J, Zimatore GB, Bertolotto A, ComiG, Uccelli A, Signori A, Angelucci E, Innocenti C, Ciceri F, Repice AM, Sormani MP, R. Saccardi R, Mancardi GL and the Italian BMT-MS study group. (2021). Long-Term Clinical Outcomes of Hematopoietic Stem Cell Transplantation in Multiple Sclerosis. Neurology 22;96(8): e1215-e1226. doi: 10.1212/WNL.0000000000011461.
Amoriello R, Chernigovskaya M, Greiff V, Carnasciali A, Massacesi L, Barilaro A, Repice AM, Biagioli T, Aldinucci A, Muraro PA, Laplaud DA, Lossius A, Ballerini C (2021). TCR repertoire diversity in Multiple Sclerosis: High-dimensional bioinformatics analysis of sequences from brain, cerebrospinal fluid and peripheral blood.EBioMedicine. 2021 Jun; 68:103429. Epub 2021 Jun 11.
Baroncini D, Simone M, Iaffaldano P, Brescia Morra V, Lanzillo R, Filippi M, Romeo M, Patti F, Chisari CG, Cocco E, Fenu G, Salemi G, Ragonese P, Inglese M, Cellerino M, Margari L, Comi G, Zaffaroni M, Ghezzi A. (2021). Italian MS registry. Risk of Persistent Disability in Patients With Pediatric-Onset Multiple Sclerosis.JAMA Neurol. Jun 1;78(6):726-735.
Contento M, Bertaccini B, Biggi M, Magliani M, Failli Y, Rosati E, Massacesi L, Paganini M. (2021). Prediction of seizure recurrence risk following discontinuation of antiepileptic drugs.Epilepsia. 2021 July12.
Contento M, Bertaccini B, Biggi M, Magliani M, Failli Y, Rosati E, Massacesi L, Paganini M. (2021) Response: Brightening the crystal ball: A constructive reappraisal of the postwithdrawal seizure relapse prediction model.Epilepsia. 62(12):3148-3149.
Mariottini A, Marchi L, Innocenti C, Di Cristinzi M, Pasca M, Filippini S, Barilaro A, Mechi C, Fani A, Mazzanti B, Biagioli T, Materozzi F, Saccardi R, Massacesi L and Repice AM (2022) Intermediate-Intensity Autologous Hematopoietic Stem Cell Transplantation Reduces Serum Neurofilament Light Chains and Brain Atrophy in Aggressive Multiple Sclerosis. Front. Neurol. 13:820256.
Mariottini A, Bulgarini G, Forci B, Innocenti C, Mealli F, Mattei A and Massacesi L. (2022). Autologous hematopoietic stem cell transplantation vs low-dose immunosuppression in secondary-progressive multiple sclerosis. European Journal of Neurology, 29:1708-1718.
Mariottini A, Bertozzi A, Marchi L, Di Cristinzi M, Mechi C, Barilaro A, Massacesi L and Repice AM. (2022) Effect of disease-modifying treatments on antibody-mediated response to anti- COVID19 vaccination in people with multiple sclerosis. Journal of Neurology, 269(6):2840-2847.
Mariottini A, Forci B, Gualdani E, Romoli M, Repice AM, Barilaro A, Mechi C, Massacesi L and Francesconi P. (2022). Incidence of malignant neoplasms and mortality in people affected by multiple sclerosis in the epoch of disease-modifying treatments: a population-based study on Tuscan residents. Multiple Sclerosis and Related Disorders,60:103679.
Azzolini F, Farina A, Gastaldi M, Barilaro A, Scotti V, Falchetti G, Fainardi E, Moretti M, and Massacesi L. (2022). Leptomeningeal gadolinium enhancement in autoimmune GFAP-astrocytopathy. Neurology,98:720-722.
Mariottini A, Repice AM, Barilaro A and Massacesi L (2022). Anti-SARS-Cov2 vaccination at the time of the COVID-19 pandemic: suspected adverse events reporting is the milestone of post-marketing surveillance". Neurological Sciences, 43:4095-4097.
MariottiniA, Marchi L., Innocenti C, Di CristinziM, Pasca M, FilippiniS, Barilaro A, MechiC, FaniA, Mazzanti B, Biagioli T, MaterozziF, Saccardi R, Massacesi L, RepiceAM. 2022. Intermediate-Intensity Autologous Hematopoietic Stem Cell Transplantation Reduces Serum Neurofilament Light Chains and Brain Atrophy in Aggressive Multiple Sclerosis. Front Neurol 24:820256.
Antonio Farina, Silvia Falso, Sara Cornacchini, Gregorio Spagni, Gabriele Monte, Alice Mariottini, Luca Massacesi, Alessandro Barilaro, Amelia Evoli, Valentina Damato. 2022. Safety and tolerability of SARS-Cov-2 vaccination in patients with myasthenia gravis: A multicenter experience. Eur J Neurol. 29:2505-2510
Bergamaschi R, BeghiE, Bosetti C, …………., L Massacesi, Maria Trojano, Mario Alberto Battaglia, Marco Capobianco, Maura Pugliatti, Monica Ulivelli, Paola Mosconi, Claudio Gasperini, Francesco Patti, Maria Pia Amato, Roberto Bergamaschi, Giancarlo Comi. 2022. Do patients' and referral centers' characteristics influence multiple sclerosis phenotypes? Results from the Italian multiple sclerosis and related disorders register. Neurol Sci. 43:5459-5469.
Amoriello R, Rizzo R, Mariottini A, Bortolotti D, Gentili V, Bonechi E, Aldinucci A, Carnasciali A, Peruzzi B, Repice AM, Massacesi L, Fainardi E, Ballerini C. (2022) Investigating Serum sHLA-G Cooperation With MRI Activity and Disease-Modifying Treatment Outcome in Relapsing-Remitting Multiple Sclerosis.Front Neurol.13:872396.
Massacesi L, Mariottini A, Nicoletti F. 2022. Relevance of Pathogenetic Mechanisms to Clinical Effectiveness of B-Cell-Depleting Monoclonal Antibodies in Multiple Sclerosis. J. Clin Med 1:4288-4293.
Cornacchini S, Farina A, Contento M, Berti V, Biggi M, Barilaro A, Massacesi L, Damato V, Rosati E. 2022. Long-term-video monitoring EEG and 18F-FDG-PET are useful tools to detect residual disease activity in anti-LGI1-Abs encephalitis: A case report. Front Neurol. 13: 949240.
Boffa G, Signori A, Massacesi L., Mariottini A, Sbragia E, Cottone S, Amato MP, Gasperini C, Moiola L, Meletti S, Repice AM, Brescia Morra V, Salemi G, Patti F, Filippi M, De Luca G, Lus G, Zaffaroni M, Sola P , Conte A, Nistri R, Aguglia U, Granella F, Galgani S, Caniatti LM, Lugaresi A, Romano S, Iaffaldano P, Cocco E, Saccardi R, Angelucci E, Troiano M, Luigi Mancardi GL, Maria Pia Sormani MP, and Inglese M.. (2023). Hematopoietic Stem Cell Transplantation In People With Active Secondary Progressive Multiple Sclerosis. Neurology, 100: e1109-e1122
Bertozzi A, Mariottini A, Marchi L, Cristinzi MD, Nistri R, Damato V, Mechi C, Barilaro A, Massacesi L, Repice AM. (2023). Safety and effectiveness of the booster dose of mRNA COVID-19 vaccines in people with multiple sclerosis: A monocentric experience. Mult Scler Relat Disord. 72:104582.
Mariottini A, Bulgarini G, Cornacchini S, Damato V, Saccardi R, Massacesi L. (2023). Hematopoietic Stem Cell Transplantation for the Treatment of Autoimmune Neurological Diseases: An Update. Bioengineering (Basel) 10(2):176.
Mosconi P, Guerra T, Paletta P, D'Ettorre A, Ponzio M, Battaglia MA, Amato MP, Bergamaschi R, Capobianco M, Comi G, Gasperini C, Patti F, Pugliatti M, Ulivelli M, Trojano M, Lepore V. and the Italian Multiple Sclerosis and Related Disorders Register Centres Group. 2023. Data monitoring roadmap. The experience of the Italian Multiple Sclerosis and Related Disorders Register. Neurol Sci. 44:4001-4011.
Beretta S., Cristillo V., Camera G., Morotti Colleoni C., Pellitteri G, Viti B, Bianchi E, Gipponi S, Grimoldi M, Valente M, Guttmann S, Cotelli MS, Palumbo P, Gelosa G, Meletti S, Schenone C, Ottaviani D, Filippi M, Zini A, Basilico P, Tancredi L, Cortelli P, Braga M, De Giuli V, Servidei S, Paolicelli D, Verde F, Caproni S, Pisani A, Lo Re V, Massacesi L, Valeria Roccatagliata DV, Manganotti P, ……….., Silani V, Tedeschi G, and Ferrarese C. (2023).Incidence and long-term functional outcome of neurological disorders in hospitalized COVID-19 patients infected with pre-Omicron variants. Neurology,101: e892-e903.
Farina A,Birzu C, Elsensohn MH, Picca A, Muñiz-Castrillo S, Vogrig A, Villagrán-García M, Ciano-Petersen NL, Massacesi L., Hervier B, Guégan S, Kramkimel N, Vano Y, Salem JE, Allenbach Y, Maisonobe T, Assaad S, Maureille A, Devic P, Weiss N, Pegat A, Maucort-Boulch D, Ricard D, Honnorat J, Psimaras D, Joubert B.. 2023. Neurological outcomes in immune checkpoint inhibitor-related neurotoxicity. Brain Communications 5: fcad169.
Mariottini A, Lotti A, Innocenti C, Repice AM, Nozzoli C, Boncompagni R, Fainardi E, Saccardi R and Massacesi L. (2023). Effect of the COVID-19 pandemic on disease activity in multiple sclerosis patients treated with hematopoietic stem cell transplantation.Eur J Neurol. 30:3362-3366.
Biggi M, Contento M, Magliani M, Giovannelli G, Barilaro A, Bessi V, Lombardo I, Massacesi L, Rosati E. (2023). Alice in wonderland syndrome "through the looking-glass" in a rare presentation of non-convulsive status epilepticus in cerebral venous sinus thrombosis and COVID-19. Cortex 167:218-222.
Lotti A, Barilaro A, Mariottini A, Vannozzi L, Piergentili M, Fainardi E and Massacesi L. (2023). Case report: 3D intracranial vessel wall MRI in Susac syndrome: potential relevance for diagnosis and therapeutic management. Front Neurol.14: 1201643.
Mariottini A, Nozzoli C, Carli I, Landi F, Gigli V, Repice AM, Ipponi A, Cecchi M, Boncompagni R, Saccardi R, Massacesi L.. 2024. Cost and effectiveness of autologous haematopoietic stem cell transplantation and high-efficacy disease-modifying therapies in relapsing-remitting multiple sclerosis. Neurol Sci. 2024 Jan 26. Online ahead of print.
Bellanca CM, Augello E, Mariottini A, Bonaventura G, La Cognata V, Di Benedetto G, Cantone AF, Attaguile G, Di Mauro R, Cantarella G, Massacesi L, Bernardini R.. (2024). Disease Modifying Strategies in Multiple Sclerosis: New Rays of Hope to Combat Disability? Curr Neuropharmacol. Jan 2024.
Iaffaldano P, Portaccio E, Lucisano G, Simone M, Manni A, Guerra T, Paolicelli D, Betti M, De Meo E, Pastò L, Razzolini L, Rocca MA, Ferrè L, Brescia Morra V, Patti F, Zaffaroni M, Gasperini C, De Luca G, Ferraro D, Granella F, Pozzilli C, Romano S, Gallo P, Bergamaschi R, Coniglio MG, Lus G, Vianello M, Banfi P, Lugaresi A, Totaro R, Spitaleri D, Cocco E, Di Palma F, Maimone D, Valentino P, Torri Clerici V, Protti A, Maniscalco GT, Salemi G, Pesci I, Aguglia U, Lepore V, Filippi M, Trojano M, Amato MP; (2024) Italian Multiple Sclerosis Register. (2024). Multiple Sclerosis Progression and Relapse Activity in Children. JAMA Neurol.;81:50-58.
Mealli F., Mattei A., Mariottini A and Massacesi L. (2024). Non-inferiority analysis of subcutaneous versus intravenous 300 mg monthly natalizumab administration: a post hoc analysis of the REFINE study. Mult Scler. Mar 13:13524585241238136.
Mariottini A, Barilaro A, Lotti A, Marra F and Massacesi L. (2024), Successful switch to ofatumumab after liver injury associated with ocrelizumab treatment in multiple sclerosis: a case report. Front Neurol.: 15:1363493
Marchi L, Mariottini A, Viti V, Bianchi A, Nozzoli C, Repice AM, Boncompagni R, Ginestroni A, Damato V, Barilaro A, Chiti S, Saccardi R, Fainardi E and Massacesi L. (2024). Leptomeningeal enhancement in multiple sclerosis: a focus on patients treated with hematopoietic stem cell transplantation. Front Neurol. 5;15:1373385. doi: 10.3389/fneur.2024.1373385.
Rinaldi C, Palumbo V., · Peyman N., · Viviani G, · Farina A. · Massacesi L. and Arba F. (2024). Adult‑onset of mild encephalitis/encephalopathy with reversible splenial lesion (MERS): case report and systematic review. Neurological Sciences. https/doi.org/10.1007/s10072-024-07627-0.
Mariottini A, Stack EH, Nair G, Nozzoli C, Wu T, Marchi L, Boncompagni R, Repice AM, Fainardi E, Pasquale FD, Carlesi E, Saccardi R, Jacobson S, Massacesi L. (2024). Spinal cord size as promising biomarker of disability outcomes after hematopoietic stem cell transplantation in multiple sclerosis. Mult Scler Relat. Disord. 88:105745.2024.
Marchi L, Mariottini A, Viti V, Bianchi A, Nozzoli C, Repice AM, Boncompagni R, Ginestroni A, Damato V, Barilaro A, Chiti S, Saccardi R, Fainardi E and Massacesi L.. (2024) Leptomeningeal enhancement in multiple sclerosis: a focus on patients treated with hematopoietic stem cell transplantation. Front Neurol. 5;15:1373385.
Mariottini A, Barilaro A, Lotti A, Marra F and Massacesi L.. (2024). Successful switch to ofatumumab after liver injury associated with ocrelizumab treatment in multiple sclerosis: a case report. Front Neurol. 2024 Feb 29;15: 1363493.
Mariottini A, Mealli F, Mattei A and Massacesi L. (2024). Comparative efficacy of subcutaneous versus intravenous natalizumab on annualized relapse rate: A post-hoc analysis of the REFINE study. Mult Scler Relat. Disord. 27; 91:105852.
Mariottini A,, Lotti A., Damato V, and Massacesi L. (2024). Challenges in Diagnosis of COVID-19 Pneumonia under Ocrelizumab and De-Risking Strategies in Multiple Sclerosis—The Elephant Is (Still) in the Room. Microorgan. 12(10): 10.3390/microorganisms12101941.
Ponzio M, Battaglia MA,Trojano M, Salivetto M, D'Ettorre A, Corrado D, Paletta P, Lepore V, Mosconi P, Comitato Scientifico del Registro Italiano Sclerosi Multipla e Patologie Correlate; Rete dei centri del Registro Italiano Sclerosi Multipla e Patologie Correlate. (2024) Epidemiol Prev 48::361-374.
Mariottini A, Boncompagni R, Cozzi D, Simonetti E, Repice AM, Damato V, Giordano M, Miele V, Nozzoli C, Massacesi L. (2024). Thymic hyperplasia after autologous hematopoietic stem cell transplantation in multiple sclerosis: a case series. Front Immunol. Nov 25; 15:1478777.
Fasano C, Bettiol A, Vastola M, Lotti A, Malandrino D, Mattioli I, Massacesi L, Emmi G, Barilaro A, Silvestri E. (2024). Effectiveness and safety of intravenous immunoglobulin for peripheral neuropathy in EGPA patients: a retrospective study. J Neurol. 272:13-16.
Frederiksen JL, Massacesi L, Nielsen HH, Rini A, Baldi E, Mirabella M, Antonella FFM, Lus G, Paolicelli D, Kant M, Salemi G, Aguglia U, Comi C, De Riz M, Barcella V, Flemmen HØ, Protti A, Farbu E, van Exel J, Torkildsen Ø. (2025). Effect of alemtuzumab on fatigue, quality of life, and patient/caregiver-reported outcomes in relapsing-remitting multiple sclerosis. A real-world evidence study. Mult Scler Relat Disord. 93:106214. doi: 10.1016/j.msard.2024.106214.
Giussani G, Bianchi E, Carlando E, DiFrancesco JC, Tabaee Damavandi P, Pasini F, Pederzoli G, Filipponi S, Gaiani A, Massacesi L, Rosati E, Giovannelli G, Cantisani TA, Cecconi M, Papetti R, Brioschi M, Aruta F, Agostoni EC, Paladin F, Dainese F, Longoni M, Yerma B, Gasparini S, Aguglia U, Ferlazzo E, Cantello R, Strigaro G, Maschio M, Benincasa D, La Neve A, Falcicchio G, Giordano A, Buttarelli L, Enia G, Leone M, Ferrarese C, Beghi E, Beretta S. (2025). Efficacy and tolerability of low versus standard daily doses of antiseizure medications in newly diagnosed focal epilepsy. A multicenter, randomized, single-blind, non-inferiority trial (STANDLOW).

Epilepsia Open. 2025 Feb 27. doi: 10.1002/epi4.70016. Online ahead of print.

Cornacchini S, Monaci A, Schiavolin M, Rosati E, Massacesi L, Berti V, Damato V. (2025). Brain [¹⁸F]FDG-PET as a marker of disease activity in a case of CASPR2 limbic encephalitis.Eur J Nucl Med Mol Imaging. Apr 7.
Bakchine S, Colosimo C, Emilsson E, Jónsdóttir SE, Massacesi L, Nonino F, Religa D, Richard E, Weydt P, Wolters FJ. Concerns about the approval of lecanemab for Alzheimer's disease. BMJ. 2025 Apr 22;389:r778.
Nonino F, Colosimo C, Massacesi L. (2025). Lecanemab and Alzheimer-Perusini's disease: between therapeutic hopes and regulatory challenges. Recenti Prog Med. 116:407-410.
Spagni G, Verza MU, Cornacchini S, Beretta F, Sun B, Lotti A, Falso S, Barilaro A, Massacesi L, Evoli A, Damato V. (2025Validation of the "Patient-Acceptable Symptom State" Question as Outcome Measure in AChR Myasthenia Gravis: A Multicentre, Prospective Study. Eur J Neurol.;32(6):e70262.
Mariottini A, Mazzeo AC, Simonetti E, Boncompagni E, Covicchio J, Barilaro A, Cutini I, Di Cristinzi M, Gozzini A, Mattei A, Mealli F, Repice AM, Nozzoli C and Massacesi L (2025). Autologous hematopoietic stem cell transplantation affects long-term progression independent of relapse activity in aggressive multiple sclerosis: a comparative matched study, JNNP, in press.

Book Chapters

Amaducci L., Massacesi L., Guarnieri B.M. (1983). Neurochemical aspects of multiple sclerosis. In "New trends of multiple sclerosis research", Cazzullo C. L., Caputo C.L., Ghezzi A. eds., pp. 125-130.
Amaducci L., Massacesi L., Guarnieri B.M., and Cambi F. (1984). Proteases, proteases inhibitors and diseases of the nervous system. In "Neuroimmunology", Behan P.O. and Spreafico F. eds., pp. 127-148. Raven Press (New York). Massacesi L. and Amaducci L. (1986). Selective immunosuppression in multiple sclerosis, in "Virology and immunology in multiple sclerosis", Cazzullo C.L., Caputo D., Ghezzi A., Zaffaroni M. editors, pp. 147-152. Springer-Verlag (Berlin).
Massacesi L., Abbamondi A.L., Castigli E., Sarlo F. and Amaducci L.(1987). Encefalomielite allergica sperimentale e acido retinoico. In "La neuroimmunologia clinica oggi", Annunziata P. and Guazzi G. eds.: 47-56, Piccin (Padova).
Massacesi L., Abbamondi A.L., Castigli E. and Amaducci L. (1988). Immunosuppression in experimental allergic encephalomyelitis. In "A multidisciplinary approach to myelin diseases", Serlupi Crescenzi G. ed. Plenum Press (New York) pp. 251-258.
Massacesi L., Abbamondi A.L., Castigli E., Sarlo F. and Amaducci L. (1988). Immunohistochemical study of the suppressive effect of retinoic acid (RA) on experimental allergic encephalomyelitis. In "Trends in European multiple sclerosis research", Confavreux C., Aimard G. and Devic M. eds. Excerpta Medica (Amsterdam), pp. 147-152.
Massacesi L., Abbamondi A.L., Sarlo S., Castigli E., Olivotto J., Vergelli M. and Amaducci L. (1989). Role of astroglial cells in experimental allergic encephalomyelitis. In “Trends in neuroimmunology”, Marrosu M.G., Cianchetti C. and Tavolato B. eds., Plenum Press (New York), pp. 97-102.
Massacesi L., Sarlo F., Abbamondi A.L., Castigli E., Olivotto J., Vergelli M., Raimondi L., Medica A. and Amaducci L. (1989). Immunosuppressive activity of Retinoic Acid (RA). In “Multiple Sclerosis Research”, M.A. Battaglia ed., Elsevier Science Publishers B.V., pp. 215-224. advances in multiple sclerosis therapy”, R.E. Gonsette, P. Delmotte, eds., Elsevier Science Publishers B.V., pp. 377-378.
Massacesi L., Sarlo F., Castigli E., Olivotto J., Vergelli M., Abbamondi A.L. and Amaducci L. (1989). Effects of retinoic acid on passive transfer EAE. In “Recent advances in multiple sclerosis therapy”, R.E. Gonsette, P. Delmotte, eds., Elsevier Science Publishers B.V., pp. 195-198.
Vergelli M., Sorrentino G. and Massacesi L. (1993). Malattie degenerative. In “Neuroimmunologia Clinica”, Bruno Tavolato ed. Il Pensiero Scientifico ed. (Roma), pp. 213-228.
Massacesi L., Amato M.P. and Amaducci L. (1994). Immunosuppression in Multiple Sclerosis: state of the art and future perspectives. In "A multidisciplinary approach to myelin diseases. II", S. Salvati ed. Plenum Press (New York), pp. 255-259.
Fonda C., Amato M.P., Massacesi L., Falcini M. Bartolozzi L. and Amaducci L. (1995). Confronto fra RM dopo somministrazione di gadolinio, senza e dopo applicazione del “trasferimento di magnetizzazione” nella sclerosi multipla. In “Neuroradiologia”, L.Bozzao editor, Centauro (Udine), pp.273-280.
Massacesi L. (1996). L’encefalomielite autoimmune sperimentale. In “Neurobiologia e Neuroimmunologia Clinica”, a cura di Federico A. e Annunziata P. CIC edizioni Internazionali (Roma), pp 85-93.
Mazzanti B., Traggiai E., Hemmer B., Martin R., Massacesi L., Vergelli M. (1999). The affinity spectrum of myelin basic protein reactive T cells. In “Advances in the immunopathogenesis of multiple sclerosis”. Gambi D., Muraro P.A.and Lugaresi A. eds. Sprinter (Milano, Italy), pp 3-10.
Vergelli M., Massacesi L., McFarland H. (2000). Immunopathogenesis of Multiple Sclerosis In “T cell autoimmunity in Multiple Sclerosis”. M. Londei ed., Landes Bioscience (Georgetown, Texas, USA), pp.133-148.
Massacesi L. (2000). Patogenesi della sclerosi multipla: meccanismo di cronicizzazione delle lesioni infiammatorie. In “Aspetti Immunologici e Terapeutici della Sclerosi Multipla” - C. Fieschi ed., UTET Periodici Scientifici (Milano), pp. 2-6.
Papini AM, Nardi, E, Mazzucco S, Mazzanti B, Traggia E, Ballerini C, Kalbacher H, Beck H, Chelli M, Ginanneschi M, Massacesi L, Vergelli M (2002). Lipophilic modifications of peptide epitopes: T-cell response and susceptibility to peptidases. In Peptides for the New Millennium, Fields G, James P.Tam, Barany G, Eds: 697-699.
Mancardi GL, Murialdo A, Saccardi R, Pagliai F, Gualandi F, Marmont A, Inglese M, Bruzzi P, Sormiani MP, Filippi, M., Marrosu M.G., Meucci G., Massacesi L, Bertolotto A, Lugaresi A., Morelli E., Filippi M e l’ Italian GITMO-NEURO Intergroup sul Trapiantato Autologo di cellule staminali ematopoietiche nella sclerosi multipla (2005). Il trapianto autologo di midollo osseo Intensa immunosoppressione seguita da trapianto autologo di cellule staminali in pazienti con forma grave di SM: dati clinici e RM. In L’interferone beta ed altre possibilità terapeutiche. L Durelli Ed., Excerpta Medica Elsevier (Milano), pp 97-106.
G.L. Mancardi, R. Saccardi, A. Murialdo, F. Pagliai, F. Gualandi, A. Marmont, M. Inglese, P. Bruzzi, M.P. Sormani, M.G. Marrosu, G. Meucci, L. Massacesi, A. Bertolotto, A. Lugaresi, E. Merelli, M. Filippi (2004) Intense Immunosuppression Followed by Autologous Stem Cell Transplantation in Severe Multiple Sclerosis Cases. In Stem Cell Therapy for Autoimmune Diseases, R. Burt ed., CRC Press, Boca Raton.

Other extended papers

Amaducci L. e Massacesi L.(1981). Modificazioni neurochimiche e prospettive di farmacologia sperimentale e clinica nella sclerosi multipla. Atti del XXII° congresso della Società Italiana di Neurologia: 197-206.
Cambi F., Massacesi L. and Amaducci L. (1982). La sclerosi multipla malattia degli anticorpi senza senso. Aggiornamento del Medico 1 (5): 39-45.
Amato M.P., Massacesi L. and Amaducci L. (1996). Clinical outcome measurements in Multiple Sclerosis trials. MS Forum. Int. MS Journal. 3(1) : 19-27.
Massacesi L. (2000). Correlati biologici e di laboratorio della patologia neuroimmune. In Atti del Convegno “Impiego delle Immunoglobuline E.V. in neurologia: attualità e prospettive”.
Massacesi L. and Vergelli M (2001). Experimental autoimmune encephalomyelitis as a model of multiple sclerosis.
Massacesi L. Ed. (2013). Percorsi assistenziali del paziente con Sclerosi Multipla. Maya Idee (Verona).
Massacesi L (2013). Ruolo delle Agenzie regolatorie nel percorso autorizzativo dei farmaci neurologici in Europa. Sclerosi Multipla news 4 (14): 4-7.
8. Mechi C., Repice A., Di Gioia M., Magnani E., Vuolo L., Bandini G., Massacesi L. (2014). Fingolimod therapy in a patient with idiopathic thrombocitopenic purpura. About Medicine 11: 23-25.
9. Sclerosi Multipla e gender medicine: position paper to practice (2015). Amato MP, Iudice A, Massacesi L., Ulivelli M. eds. Maya Idee (Verona).

I herewith authorize processing of my personal data.

Florence, 18 Luglio 2025

Luca Massacesi

curriculum vitae

Personal information

Name		Luca Massacesi
Address		Dept. of Neurosciences, Drugs and Child Health, University of Florence, Viale Pieraccini, 6 - 50139 Florence, Italy Department of Neurosciences, Careggi University Hospital - University of Florence, Largo Brambilla 3 - 50134, Florence, Italy.
Telephone		+39 0552751697
Fax		+39 0552751898
E-mail		massacesi@unifi.it
Nationality		italian
Date of birth		30.11.1954

Current Position
• Name and address of employer		Florence University, Florence, Italy
• Type of business or sector		Dept. of Neurosciences, Drugs and Child Health
• Occupation or position held		Full Professor of Neurology
• Main activities and responsibilities		Research, Teaching, Clinical care

• Name and address of employer		Careggi University Hospital-University of Florence
• Type of business or sector		Dept. of Neurosciences
• Occupation or position held		Director
• Main activities and responsibilities		Management of clinical/ research activities, Clinical Governance
• Type of business or sector		IInd Neurology Division,
• Occupation or position held		Director
• Main activities and responsibilities		Patient clinical care, Clinical management, Teaching, Research,

Expertise

· Principal areas of expertise

Clinical neurology, neuroimmunology, inflammatory diseases of the nervous system, imaging of the nervous system

Work experience

• Dates (from – to)		1984-1988
• Name and address of employer		University of Florence, Florence, Italy
• Type of business or sector		Dept. of Neurology
• Occupation or position held		National Research Council research fellow
• Main activities and responsibilities		Research

• Dates (from – to)		1988-1991
• Name and address of employer		Massachusetts General Hospital, Harvard University, Boston, Ma, USA
• Type of business or sector		Neuroimmunology Unit, Dept. of Neurology
• Occupation or position held		postdoctoral fellow.
• Main activities and responsibilities		research

• Dates (from – to)		1991-2007
• Name and address of employer		Careggi University Hospital, Florence, Italy
• Type of business or sector		Ist NeurologyDivision
• Occupation or position held		Staff neurologist
• Main activities and responsibilities		Patients clinical care

• Dates (from – to)		1995-2001
• Name and address of employer		Florence University, Florence, Italy
• Type of business or sector		Dept. of Neurological and Psichiatric Sciences
• Occupation or position held		Assistant Professor of Neurology
• Main activities and responsibilities		Research and patient clinical care

• Dates (from – to)		2001-2005
• Name and address of employer		Florence University, Florence, Italy
• Type of business or sector		Dept. of Neurological And Psichiatric Sciences
• Occupation or position held		Associated Professor in Neurology
• Main activities and responsibilities		Teaching, Research, patient clinical care

• Dates (from – to)		2005-today
• Name and address of employer		Florence University, Florence, Italy
• Type of business or sector		Dept. of Neurosciences Drugs and Child Health
• Occupation or position held		Full Professor of Neurology
• Main activities and responsibilities		Teaching, Research, patient clinical care

• Dates (from – to)		2008-today
• Name and address of employer		Dept. of Neurosciences, Careggi University Hospital-University of Florence, Florence, Italy,
• Type of business or sector		IInd Neurology Division,
• Occupation or position held		Director
• Main activities and responsibilities		Clinical care, Clinical management, Teaching, Research,

• Dates (from – to)		2008-2012
• Name and address of employer		Florence University, Florence, Italy
• Type of business or sector		PHD Program in Neurosciences
• Occupation or position held		Coordinator
• Main activities and responsibilities		Research organization, research supervision

• Dates (from – to)		2008-2012
• Name and address of employer		Florence University, Florence, Italy
• Type of business or sector		Resident Program in Neurophysiopathology
• Occupation or position held		Director
• Main activities and responsibilities		Teaching and tutoring residents, patient clinical care, management

• Dates (from – to)		2009-2010
• Name and address of employer		National Institute of Health, Bethesda, MD, USA
• Type of business or sector		NINDS, Neuroimmunology Branch
• Occupation or position held		Adjunct Scientist
• Main activities and responsibilities		research

• Dates (from – to)		2010-today
• Name and address of employer		National Institute of Health, Bethesda, MD, USA
• Type of business or sector		NINDS, Neuroimmunology Branch
• Occupation or position held		Visiting Scientist
• Main activities and responsibilities		research

• Dates (from – to)		2012-today
• Name and address of employer		Careggi University Hospital-University of Florence, Florence, Italy
• Type of business or sector		Dept. of Neurosciences
• Occupation or position held		Director
• Main activities and responsibilities		Management of clinical and research activities

Education and training

• Date		1982
• Name and type of organization providing education and training		University of Florence
• Principal subjects/occupational skills covered		School of Medicine and Surgery
• Title of qualification awarded		Medical degree
• Level in national classification		110/110 cum laude

• Date		1986
• Name and type of organization providing education and training		University of Florence
• Principal subjects/occupational skills covered		Resident program in Clinical Neurology
• Title of qualification awarded		Specialization in Neurology
• Level in national classification		70/70 cum laude

• Date		1990
• Name and type of organization providing education and training		University of Florence
• Principal subjects/occupational skills covered		Resident program in Clinical Immunology
• Title of qualification awarded		Specialization in Clinical Immunology
• Level in national classification		70/70 cum laude

• Date		1982
• • Name and type of organization providing education and training		Stanford University, Palo Alto. Ca, USA.,
• Type of business or sector		Neurology Department, Laboratory of Neurochemistry
• Occupation or position held		visiting fellow.
• Main activities and responsibilities		research

• Date		1985
• • Name and type of organization providing education and training		National Institute of Health, Bethesda, Ma, USA
• Type of business or sector		NINDS, Neuroimmunology Branch
Occupation or position held		visiting fellow
• Main activities and responsibilities		research

Additional information

• Dates (from – to)		ORGANIZATION AND COORDINATION OF RESEARCH GROUPS.
1994-1997,		Project Leader of the international project "Concerted Action on T-cell Autoimmunity in Multiple Sclerosis". R&D program of the del General Directorate XII of the European Union Commission.
1997-1999		Coordinator of the italian multicentric project funded by the Associazione Italiana Sclerosi Multipla (AISM) entitled “Centralized Facility per genetic studies in Multiple Sclerosis.
1998-2001		Scientific Coordinator of the study entitled “Open randomized clinical study on different doses of bIFN1a, also in association with Azathioprine, in patients with relapsing remitting multiple sclerosis”.
2006-2011		Coordinator of the multicentric Randomized Controlled Trial funded by the Italian Drug Agency (AIFA) “Randomized controlled study of Azathioprine versus Interferon beta in relapsing-remitting multiple sclerosis”.

			FURTHER SCIENTIFIC ACTIVITIES
1993-today			- Italian Multiple Sclerosis Society (AISM); member of the Scientific Committee and of the Research Evaluation Committee.
1994-1997			- "Concerted Action on T-cell Autoimmunity in Multiple Sclerosis" R&D program of the del DG XII EU Commission, Project Leader.
1999-2000			- International Federation of Multiple Sclerosis Societies Scientific Program Committee; member of the Medical Advisory Board.
1995-2001			- Biomedical Primate Research EU Large Scale Facility, Rijswijk, The Nederland; member of the Scientific Committee.
2009-today			- European Medicines Agency (EMA), London, UK; Scientific Advisory Group – Neurology, member.
2009-today			- Italian Medicines Agency (AIFA), Rome, Italy; Scientific Advisory Committee on Neurosciences, member.
2010-2012			- National Institutes of Health, Bethesda MD, USA. Data and Safety monitoring board (DSMB) of the phase II intramural clinical study: Investigating mechanism of action of DAC HYP (Daclizumab) in the treatment of high inflammatory multiple sclerosis: Chairman

CURRENT TEACHING ACTIVITY AT FLORENCE UNIVERSITY

Course Subject

- 2002-today, School of Medicine: Clinical Neurology;

- 2005-today, School of Dentistry: Clinical Neurology;

- 2005-today, School of Nursing: Clinical Neurology;

- 2005-2009, Faculty of Experimental. Psycology: Clinical Neurology;

- 2005-today, Resident Program in Neurology: Clinical Neurology;

- 2005-2013, Resident Program in Neurophysiopathology: Clinical Neurology;

- 2009-today, Resident Program in Emergency Medicine: Clinical Neurology;

- 1991-today, School of Medicine, mentor of 25 Thesis dissertations;

- 1995-today,PhD program in Neurosciences, Supervisor of 12 PhD dissertations.

AFFILIATIONS TO SCIENTIFIC SOCIETIES

- Società Italiana di Neurologia.

- European Federation of Neurological Societies

- Associazione Italiana di Neuroimmunologia.

- International Society of Neuroimmunology.

- Società Italiana di Immunologia.

REVIEWER FOR

Journal of Neuroimmunology,

Journal Clinical Neurology and Neurosurgery,

Journal of Immunology,

Neurological Sciences,

Intl. MS journal,

Italian Multiple Sclerosis Society,

Dutch Multiple Sclerosis Society,

Singapore Medical Research Council

PLOs Medicine

PLOS Pathology

Italian Ministry of University and Research

Multiple Sclerosis International, member of the editorial board

ANNEXES

PUBLICATIONS

Publications on international Journal quoted in “PubMed”, National Library of Medicine (USA).

1. Raimondi L., Banchelli Soldaini G., Buffoni F., Ignesti G., Massacesi L., Amaducci L. and Friedmann C.A. (1982). Rhein and derivatives. In vitro studies on their capacity to inhibit certain proteases. Pharmacol. Res. Comm., 14(2): 103-112.
2. Smith M.E., Somera F.P., Saldivar R., Massacesi L. and Trotter J. (1984). DNA changes in spinal cords of rats with experimental allergic encephalomyelitis.J. Neurochem., 43: 1635-1641.
3. Massacesi L., Abbamondi A.L., Sarlo F. and Amaducci L. (1987). The control of experimental allergic encephalomyelitis with retinoic acid. Further studies. Riv. Neurol. 57:166-169.
4. Massacesi L., Abbamondi A.L., Giorgi C., Sarlo F., Lolli F. and Amaducci L. (1987). Suppression of experimental allergic encephalomyelitis by retinoic acid. J. Neurol. Sciences, 80:55-64.
5. Massacesi L., Abbamondi A.L., Raimondi L., Giorgi C. and Amaducci L. (1988). Lysosomal enzymes in experimental allergic encephalomyelitis: time course and evidence of the source. Neurochem. Res., 13:165-169.
6. Theoharides TC, Lambrachthall M, Massacesi L, et al. (1990). Reduced incidence of experimental allergic encephalomyelitis (EAE) with the tricyclic sep-ch. Europ. J. Pharmacol., 183: 626-627.
7. Massacesi L., Castigli E., Vergelli M., Olivotto J., Abbamondi A.L., Sarlo F. and Amaducci L. (1991). Immunosuppressive activity of 13-cis retinoic acid and prevention of experimental autoimmune encephalomyelitis in rats. J.Clin.Invest., 88:1331-1337.
8. Riskind P., Massacesi L., Doolittle T.H. and Hauser S.L. (1991).The role of prolactin in autoimmune demyelination: suppression of experimental allergic encephalomyelitis by bromocriptine. Ann. Neurol., 29: 542-547.
9. Zehetbauer B., Massacesi L., Liuzzi G. M., Vergelli M., Olivotto J., Grassi L., Riccio P. and Amaducci L. (1991). Myelin Basic Protein in lipid-bound form induces experimental allergic encephalomyelitis and demyelination in Lewis rat. Acta Neurologica 13: 121-132.
10. Massacesi L., Parritz D., Joshi N, Letvin N. and Hauser S.L.(1992). Experimental allergic encephalomyelitis in Cynomolgus Monkeys: quantitation of T-cell responses in peripheral blood. J.Clin. Invest., 90: 399-404.
11. Salvetti M and Massacesi L. (1992). Experimental allergic encephalomyelitis and multiple sclerosis: immunoregulatory mechanisms and T cell repertoires. Cell. Immunol., 142: 217-219.
12. Salvetti M., Buttinelli C., Massacesi L. and Wekerle H. (1993). New approaches to the study of T-cell autoimmunity in multiple sclerosis. J. Neuroimmunol., 47: 203-205.
13. Yu J.S., Pandey J. P., Massacesi L., Lincoln R., Usuku K., Seboun E. and Hauser S.L. (1993). Segregation of Immunoglobulin heavy Chain constant region genes in Multiple sclerosis sibling pairs. J. Neuroimmunol., 42: 113-116.
14. Lolli F., Liuzzi G.M., Vergelli M., Massacesi L., Ballerini C., Amaducci L. and Riccio P. (1993). Antibodies specific for the lipid-bound form of myelin basic protein during experimental autoimmune encephalomyelitis. J. Neuroimmunol., 44: 69-75
15. Massacesi L., Vergelli M., Zehetbauer B., Liuzzi G.M., Olivotto J., Ballerini C., Uccelli A., Mancardi L., Riccio P. amd Amaducci L. (1993). Induction of experimental autoimmune encephalomyelitis in rats and immune response to myelin basic protein in lipid bound form. J. Neurol. Sciences, 119: 91-98.
16. Da Vico S., Massacesi L., Amaducci L. (1993). Survey of the italian neurological output in the three years 1989-1991. It J. Neurol. Sci., 14: 595-598.
17. Genain C.P., Parritz D., Hoa Nguyen M., Massacesi L., Ioshi N., Ferrante R., Hoffman K., Moseley M., Levtin N., Hauser S. (1994). In healthy primates, circulating autoreactive T-cells mediate autoimmune disease. J. Clinic. Invest., 94: 1339-1345.
18. Vergelli M., Mazzanti B., Ballerini C., Gran B., Amaducci L. and Massacesi L. (1995). Trasforming growth factor-beta1 inhibits the proliferation of rat astrocytes induced by serum and growth factors. J. Neurosc. Res., 40: 127-133.
19. Massacesi L., Genain C.P., Parritz D.L., Canfield D., Letvin N. and Hauser S.L. (1995). Active and passively induced experimental autoimmune encephalomyelitis in common marmosets: a new model for multiple sclerosis. Ann. Neurol., 37: 519-530.
20. Hohlfeld R., Londei M., Massacesi L. and Salvetti M. (1995).T-cell autoimmunity in multiple sclerosis. Immunology Today (now Trends in Immunology), 16:259-261.
21. Amato M.P., Massacesi L. and Amaducci L. (1996). Clinical outcome measurements in Multiple Sclerosis trials. MS Forum. Int. MS Journal 3 n(1) : 19-27.
22. Vergelli M., Olivotto J., Castigli E., Gran B., Raimondi L., Pirisino R., Amaducci L. and Massacesi L. (1997). Immunosuppressive activity of 13-cis-retinoic acid in rats: Aspects of pharmacokinetics and pharmacodynamics. Immunopharmacol., 37: 191-197.
23. Mazzanti B. , M. Vergelli, P. Riccio, R. Martin, H.F. McFarland, G.M. Liuzzi, L. Amaducci and Massacesi L. (1998). T cell response to Myelin Basic Protein in patients with Multiple Sclerosis and healthy donors. J. Neuroimmunol., 82: 96-100.
24. Gran B., Gestri D., Sottini A., Quiròs Roldàn E., Bettinardi A., Signorini S., Primi D., Ballerini C., Taiuti R., Amaducci L. and Massacesi L. (1998). Detection of skewed T-cell receptor V-beta gene usage in the peripheral blood of patients with multiple sclerosis. J. Neuroimmunol., 85: 22-32.
25. Cascino I., Ballerini C., Audino S., Rombolà G., Massacesi L., Colombo G., Scorza Smeraldi R., D’Alfonso S., Momigliano Richiardi P., Tosi R., Ruberti G. (1998). Fas Gene Polymorphisms are not associated with Systemic Lupus Erythematosus, Multiple Sclerosis and HIV Infection. Disease Markers, 13: 221-225.
26. Laman J.D., van Meurs M., Schellekens M.M., de Boer M., Melchers B., Massacesi L., Lassmann H., Klaassen E., ‘t Hart B. (1998). Expression of accessory molecules and cytokines in acute EAE in marmoset monkeys (Callithrix jacchus). J. Neuroimmunol., 86: 30-45.
27. ‘t Hart B., Bauer J., Muller H.J., Melchers B., Nicolay K., Brok H., Bontrop R., Lassmann H. and Massacesi L. (1998) Histopathological characterization of magnetic resonance imaging-decectable brain white matter lesions in a primate model of multiple sclerosis. Am. J. Pathol., 153: 649-663.
28. Kappos, L; Polman, C; Pozzilli, C et al (1998). Placebo-controlled multicentre randomised trial of Interferon beta-1b in treatment of secondary progressive multiple sclerosis. Lancet, 352: 1491-97.
29. Mazzucco S., Nardi E., Chelli M., Ginanneschi M., Rapi G., Papini A.M., Vergelli M., Mazzanti B., Massacesi L., Amaducci L. (1999). Synthesis of lipopeptides of the immunodominant epitope hMBP(83-99) containing amide or C-C bond linked hydrophobic chains for the study of T cell response. Letters in Peptide Sciences 6: 51-59.
30. Mazzucco S., Matà S., Vergelli M., Fioresi R., Nardi E., Mazzanti B., Chelli M., Lolli F., Ginanneschi M., Pinto F., Massacesi L. and Papini A.M. (1999). A synthetic glycopeptide of human myelin oligodendrocyte glycoprotein to detect antibody responses in multiple sclerosis and other neurological diseases. Bioorg. Med. Chem. Lett. : 167-172.
31. Sabbadini M.G., Manfredi AA., Bozzolo E., Ferrario L., Rugarli C., Scorza R., Origgi L., Vanoli M., Gambini O., Vanzulli L., Croce D., Campana A., Messa C., Fazio F., Tincani A., Anzola G., Cattaneo R., Padovani A., Gasparotti R., Gerli R., Quartesan R., Piccirilli M., Farsi A., Emmi E., Domeneghetti M., Piccini C., Massacesi L., Pupi A., De Cristoforis M., Danieli M., Candela M., Fraticelli P., Bartolini M., Savolini U., Danieli G. and Passaleva A. (1999). Central Nervous system involvement in Systemic Lupus Eritematosus patients without overt neuropsychiatric manifestations. Lupus 8: 11-19.
32. D’Alfonso S., Nisticò L., Zavattari P., Marrosu M., Murru R., Lai M., Massacesi L., Ballerini C., Gestri D., Salvetti M., Ristori G., Bomprezzi R., Trojano M., Liguori M., Gambi D., Quattrone A., Fruci D., Cucca F., Momigliano Richiardi P. and Tosi R. (1999). A linkage analysis of Multiple Sclerosis with candidate region markers in Sardinian and Continental Italian families. Eur. J Hum.Gen. 7 : 377-385.
33. Miller D.H., Molyneux P.D., Barker G.J., Mac Manus D.G., Moseley I.F., Wagner K.,and the European Study Group on Interferon-Beta1b in Secondary Progressive Multiple Sclerosis. (1999) Effect of Interferon-Beta1b on Magnetic Resonance Imaging Outcomes in Secondary Progressive Multiple Sclerosis: Results of a European Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial. Ann. Neurol., vol. 46, 850-859.
34. Ballerini C. Nacmias B., Rombolà G., Marcon G., Massacesi L., Sorbi S. (1999) HLA A2 Allele Is Associated with Age at Onset of Alzheimer’s Disease. Ann. Neurol., vol. 45: 397-400.
35. Mazzanti B., Hemmer B., Traggiai E., Ballerini C., McFarland H.F., Massacesi L., Martin R. and Vergelli M. (2000). Decrypting the Spectrum of Antigen-Specific T-Cell Responses: The Avidity Repertoire of MBP-Specific T-Cells. J. Neurosci. Res., 59:86-93.
36. ‘t Hart B.A., van Meurs M., Brok H.P.M., Massacesi L., Bauer J., Boon L., Bontrop R.E and Laman J.D. (2000). A new primate model for multiple sclerosis in the common marmoset. Immunology Today (ora Trends in Immunology), 21: 290-297.
37. Pupi A., Sestini S., De Cristofaro M.T., Emmi L., Marchione T., Salvati G., Li Gobbi F., Massacesi L., Meldolesi U. (2000). Use of technetium-99mhexametylpropyleneamine oxime single-photon emission tomography for the study of cerebral blood flow reactivity after acetazolamide infusion in patients with Behcet’s disease. Eur. J. Nucl. Med. 27(6): 700-706.
38. D’Alfonso S., Nisticò L., Bocchio D., Bomprezzi R., Marrosu M.G., Murru M.R., Lai M., Massacesi L., Ballerini C., Repice A., Solvetti M., Montesperelli C., Ristori G., Trojano M., Liguori M., Gambi D., Quattrone A., Tosi R., Momigliano-Richiardi P. (2000). An attempt of identifying MS-associated loci as a follow-up of a genomic linkage study in the Italian population. J. Neurovirol. 6 (S 2):18-22.
39. Molyneux P.D., Kappos L., Polman C., Pozzilli C., Barkhof F., Filippi M., Yousry T., Hahn D., Wagner K., Ghazi M., Beckmann K., Dalhke F., Losseff N., Barker G.J., Thompson A.J., Miller D.H. and the European Study Group on Interferon beta-1b in Secondary Progressive Multiple Sclerosis (2000). The effect of interferon beta-1b treatment on MRI measures of cerebral atrophy in secondary progressive multiple Sclerosis. Brain 123: 2256-2263.
40. Ballerini C., Campani D., Rombolà G., Gran B., Nacmias B., Amato M.P., Siracusa G., Bartolozzi L., Sorbi S. and Massacesi L. (2000). Association of apolipoprotein E polymophism to clinical heterogeneity of multiple sclerosis. Neurosci. Lett. 296: 174-176.
41. Papini AM, Mulinacci B, Carotenuto A, Bonetti B, Sabatino G, Peron E, Nuti F, Alcaro MC Pozo-Carrero MC, Mazzanti, B, Pazzagli m, Massacesi L, Battistini L, Chelli, M, Rovero, P, Lolli, F, Chorev M, Sawyer, TK, 2001. MS PepKit: The first diagnostic test to follow-up multiple sclerosis. Peptide Revolution: Genomics, Proteomics & Therapeutics
42. Chiarugi A., Cozzi A., Ballerini C., Massacesi L. and Moroni F. (2001). Kynurenine 3-monoxygenase activity and neurotoxic kynurenine metabolites increase in the spinal cord of rats with experimental allergic encephalomyelitis. Neuroscience 102: 687 - 695.
43. Mancardi G., t’Hart B., Roccatagliata L., Brok H., Giunti D., Bontrop R., Massacesi L., Capello E. and Uccelli A. (2001.) Demyelination and axonal damage in a non-human primate model of multiple sclerosis. J. Neurol. Sciences 184: 41-49.
44. Gestri D., Baldacci L., Taiuti R., Galli E., Maggi E., Piccinni M.P., Vergelli M. and Massacesi L. (2001). Oligoclonal T-cell repertoire in cerebrospinal fluid of patients with nervous system inflammatory diseases. J. Neurol. Neurosurg. Psych. 70: 767- 772.
45. Broadley S., Sawcer S., D'Alfonso S., Henseik A., Coraddu F., Gray J., Roxburgh R., Clayton D., Buttinelli C., Quattrone A, Trojano M., Momigliano Richiardi P. , Massacesi L. and Compston A. (2001). A genome screen for multiple sclerosis in Italian families. Genes Immun. 2: 205-10.
46. Mancardi G.L., Saccardi, R., Filippi, M., Gualandi F., Murialdo A., Inglese M., Marrosu M.G., Meucci G., Massacesi L., Lugaresi A., Pagliai F., Sormani M.P., Sardanelli F., Marmont A. and the Italian Gitmo-Neuro Intergroup on Autologous Hematopoietic Stem Cell Transplantation for Multiple Sclerosis (2001). Autologous hematopoietic stem cell transplantation suppresses Gadolinium-enhanced MRI activity in multiple sclerosis. Neurology 57:62-68.
47. Papini A.M., Mazzanti B., Nardi E., Traggiai E., Ballerini C., Biagioli T., Kalbacher H., Beck H., Deeg M., Chelli M., Ginanneschi M., Massacesi L., Vergelli M. (2001). Palmitoyl Derivatives of GpMBP Epitopes: T-Cell Response and Peptidases Susceptibility. J. Med. Chem 44: 3504- 3510.
48. Soldan S. S., Fogdell-Hahn A., Brennan M. B., Mittleman B. B., Ballerini C., Massacesi L., Seya T., McFarland H. F. and Jacobson S. (2001). Elevated serum and CSF levels of soluble HHV-6 cellular receptor, membrane cofactor protein (MCP; CD46), in patients with multiple sclerosis. Ann. Neurol. 50: 486-93.
49. Vergelli M., B. Mazzanti, E. Traggiai, T. Biagioli, C. Ballerini, A Parigi, G. Pellicanò, A. Konze, Massacesi L (2001). Short-term evolution of autoreactive T-cell repertoire in multiple sclerosis. J Neurosci Res. 66:517-24.
50. Traggiai E., Biagioli T., Rosati E., Ballerini C., Mazzanti B., Ben Nun A., Massacesi L., Vergelli M. (2001). IL-7-enhanced T-cell response to myelin proteins in multiple sclerosis. J. Neuroimmunol. 121:111-9.
51. Kappos L., Polman C., Pozzilli C., Thompson A., Beckmann K., Dalhke F., and the European Study Group on Interferon beta-1b in Secondary Progressive Multiple Sclerosis (2001). Final analysis of the European multicenter trial on IFNbeta-1b secondary progressive Multiple Sclerosis. Neurology 57: 1969-1975.
52. Freeman J, Thompson A., Fitzpatrick R., Hutchinson M., Miltenburger C., Beckmann K., Kappos L., Dalhke F., Polman C., Pozzilli C., and the European Study Group on Interferon beta-1b in Secondary Progressive Multiple Sclerosis (2001). IFNbeta-1b in the treatment of secondary progressive Multiple Sclerosis. Impact on quality of life. Neurology 57: 1870-1875.
53. Molyneux PD, Barker GJ, Barkhof F, Beckmann K, Dahlke F, Filippi M, Ghazi M, Hahn D, MacManus D, Polman C, Pozzilli C, Kappos L, Thompson AJ, Wagner K, Yousry T, Miller DH; European Study Group on Interferon Beta-1b in Secondary Progressive MS (2001). Clinical-MRI correlations in a European trial of interferon beta-1b in secondary progressive MS.Neurology 57: 2191-7.
54. D'Alfonso S., Mellai M., Giordano M., Pastore A., Malferrari G., Naldi P., Repice A., Liguori M., Cannoni S., Milanese C., Caputo D., Savettieri G., Momigliano-Richiardi P. and the Italian Group for the Study of Multiple Sclerosis Genetics(2002). Identification of single nucleotide variations in the coding and regulatory regions of the myelin-associated glycoprotein gene (MAG) and study of their association with multiple sclerosis. J. Neuroimmunol. 126 : 196-204.
55. Muraro, P.A., Bonanni, L., Mazzanti B., Pantalone, A., Traggiai, E., Massacesi L., Vergelli, M., Gambi, D. (2002). Short-term dynamics of circulating T cell receptor V beta repertoire in relapsing-remitting MS. J. Neuroimmunol. 127: 149-59.
56. Massacesi L. (2002). Compartmentalization of the immune response in the central nervous system and natural history of multiple sclerosis. Implications for therapy. Clin Neurol Neurosurg 104: 177-81.
57. Ballerini C., Rosati E., Salvetti M., Ristori G., Cannoni S., Biagioli T., Massacesi L., Sorbi S., Vergelli M. (2002). PTPRC exon 4 gene mutation distribution in a Italian MS population. Neuroscience Letters 328: 325-7.
58. Buzzetti R., Pozzilli P., Di Mario U., Ballerini C., and Massacesi L. (2002). Multiple sclerosis and Type I diabetes. Diabetologia 45: 1735-6.
59. Mellai M., Giordano M., D’Alfonso S., Marchini M., Scorza R., Danieli M.G., Leone M., Ferro I., Liguori M., Trojano M., Ballerini C., Massacesi L., Cannoni S., Bomprezzi R., Momigliano-Richiardi P. (2003). Prolactin and prolactin receptor gene polymorphisms in multiple sclerosis and systemic lupus erythematosus. Human Immunol. 64: 274-284.
60. Polman C, Kappos L, White R, Dahlke F, Beckmann K, Pozzilli C, Thompson A, Petkau J, Miller D; European Study Group in Interferon Beta-1b in Secondary Progressive MS (2003). Neutralizing antibodies during treatment of secondary progressive MS with interferon beta-1b. Neurology 60: 37-43.
61. Sormani MP, Bruzzi P, Beckmann K, Wagner K, Miller DH, Kappos L, Filippi M; European Study Group on Interferon Beta-1b in Secondary Progressive MS (2003). MRI metrics as surrogate endpoints for EDSS progression in SPMS patients treated with IFN beta-1b. Neurology 60: 1462-6.
62. Alizadeh M, Babron MC, Birebent B, Matsuda F, Quelvennec E, Liblau R, Cournu-Rebeix I, Momigliano-Richiardi P, Sequeiros J, Yaouanq J, Genin E, Vasilescu A, Bougerie H, Trojano M, Martins Silva B, Maciel P, Clerget-Darpoux F, Clanet M, Edan G, Fontaine B, Semana G. (2003) and the Portuguese and Italian Group for MS genetics. Genetic interaction of CTLA-4 with HLA-DR15 in multiple sclerosis patients. Ann Neurol. 54:119-22.
63. Akesson E, Coraddu F, Marrosu MG, Massacesi L, Hensiek A, Harbo HF, Oturai A, Trojano M, Momigliano-Richiardi P, Cocco E, Murru R, Hillert J, Compston A and Sawcer S (2003). Refining the linkage analysis on chromosome 10 in 449 sib-pairs with multiple sclerosis. J Neuroimmunol. 143: 31- 38.
64. Liguori M, Sawcer S, Setakis E, Compston A, Giordano M, D'Alfonso S, Mellai M, Malferrari G, Trojano M, Livrea P, De Robertis F, Massacesi L, Repice A, Ballerini C, Biagioli T, Bomprezzi R, Cannoni S, Ristori G, Salvetti M, Grimaldi LM, Biunno I, Comi G, Leone M, Ferro I, Naldi P, Milanese C, Gellera C, Loredana LM, Savettieri G, Salemi G, Aridon P, Caputo D, Rosa Guerini F, Ferrante P, and Momigliano-Richiardi P (2003). A whole genome screen for linkage disequilibrium in multiple sclerosis performed in a continental Italian population. J Neuroimmunol. 143: 97-100.
65. Ballerini C, Guerini F, Rombolà G, Rosati E, Massacesi L, Ferrante P, Caputo D, Figà Talamanca L, Naldi P, Liguori M, Alizadeh M, Momigliano-Richiardi P, D’Alfonso S (2004). HLA-Multiple Sclerosis association in Continental Italy and correlation with disease prevalence in Europe. J Neuroimmunol. 150:178 -85.
66. IngleseM, G L Mancardi, E Pagani, M A Rocca, A Murialdo, R Saccardi, G Comiand M Filippi the Italian GITMO-NEURO Intergroup on Autologous Hemotopoietic Stem Cell Transplantation (2004).Brain tissue loss occurs after suppression of enhancement in patients with multiple sclerosis treated with autologous haematopoietic stem cell transplantation. J. Neurol. Neurosurg. Psych. 75: 643-644.
67. Saccardi R, Mancardi GL, Solari A, Bosi A, Bruzzi P, Di Bartolomeo P, Donelli A, Filippi M, Guerrasio A, Gualandi F, La Nasa G, Murialdo A, Pagliai F, Papineschi F, Scappini B, Marmont AM. and the Italian GITMO-NEURO Intergroup on Autologous Hemotopoietic Stem Cell Transplantation (2005). Autologous HSCT for severe progressive multiple sclerosis in a multicenter trial: impact on disease activity and quality of life. Blood. 105:2601-7.
68. MazzantiB, Biagioli T., Aldinucci A., Cavaletti G., CavalettiE., Crippa L., Oggioni N.,Sala F., Sala V., Frigo M., Rota S., Tagliabue E., Ballerini C., Massacesi L., Riccio P. and Lolli F. (2005). Effects of Pixantrone on T- and B-cell function in the course of acute rat experimental allergic encephalomyelitis. J. Neuroimmunol. 168: 111-117.
69. Capello E, Saccardi R, Murialdo A, Gualandi F, Pagliai F, Bacigalupo A, Marmont A, Uccelli A, Inglese M, Bruzzi P, Sormani MP, Cocco E, Meucci G, Massacesi L, Bertolotto A, Lugaresi A, Merelli E, Solari A, Filippi M, Mancardi GL; Italian GITMO-Neuro Intergroup on ASCT for Multiple Sclerosis (2005). Intense immunosuppression followed by autologous stem cell transplantation in severe multiple sclerosis. Neurol Sci. 26: S200-3.
70. Massacesi L, Parigi A, Barilaro A, Repice AM, Pellicanò G, Konze A, Siracusa GF, Taiuti R and Amaducci L. (2005). Efficacy of Azathioprine on Multiple Sclerosis new brain lesions evaluated by Magnetic Resonance Imaging. Arch.Neurol.;62:1843-1847.
71. Ristori G, Cannoni S, Stazi MA, Vanacore N, Cotichini R, Alfo M, Pugliatti M, Sotgiu S, Solaro C, Bomprezzi R, Di Giovanni S, Figa Talamanca L, Nistico L, Fagnani C, Neale MC, Cascino I, Giorgi G, Battaglia MA, Buttinelli C, Tosi R, Salvetti M. and the Italian MS genetic collaborative group (2006). Multiple sclerosis in twins from continental Italy and Sardinia: A nationwide study. Ann Neurol.59(1):27-34.
72. The GAMES Collaborative Group, Ban M, Booth D, Heard R, Stewart G, Goris A, Vandenbroeck K, Dubois B, Laaksonen M, Ilonen J, Alizadeh M, Edan G, Babron MC, Brassat D, Clanet M, Cournu-Rebeix I, Fontaine B, Semana G, Goedde R, Epplen J, Weber A, Infante-Duarte C, Zipp F, Rajda C, Bencsik K, Vécsei L, Heggarty S, Graham C, Hawkins S, Liguori M, Momigliano-Richiardi P, Caputo D, Grimaldi LM, Leone M, Massacesi L, Milanese C, Salvetti M, Savettieri G, Trojano M, Bielecki B, Mycko MP, Selmaj K, Santos M, Maciel P, Pereira C, Silva A, Silva BM, Coraddu F, Marrosu MG, Akesson E, Hillert J, Datta P, Oturai A, Harbo HF, Spurkland A, Goertsches R, Villoslada P, Eraksoy M, Hensiek A, Compston A, Setakis E, Gray J, Yeo TW, Sawcer S. (2006). Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans. J. Neuroimmunol.179: 108-116.
73. Saccardi R, Kozak T, Bocelli-Tyndall C, Fassas A, Kazis A, Havrdova E, Carreras E, Saiz A, Löwenberg B, te Boekhorst P, GualandiF, Openshaw H, Longo G, Pagliai F, Massacesi L, Deconink E, Ouyang J, Zuazu Nagore F, Besalduch J, Lisukov I, Bonini A, Merelli E,Slavin S, Gratwohl A, Passweg J, Tyndall A, Steck A, Andolina M, Capobianco M, Diez Martin J, Lugaresi A,Meucci G, Sáez R,Clark R, Fernandez M, Fouillard L, Herstenstein B, Koza V, Cocco E, Baurmann H and Mancardi G on behalf of the Autoimmune Disease Working Party of EBMT (2006). Autologous stem cell transplantation for progressive multiple sclerosis: update of the European group for blood and marrow transplantation auto-immune diseases working party database. Mult. Sclerosis 12: 814-823.
74. Roccatagliata L, Rocca M, Valsasina P, Bonzano L, Sormani M, Saccardi R, Mancardi G, Filippi M; for the Italian GITMO-NEURO Intergroup on Autologous Stem Cell Transplantation.(2007). The long-term effect of AHSCT on MRI measures of MS evolution: a five-year follow-up study. Mult Sclerosis. 13: 1068-70.
75. Aldinucci A., Gerlini G., Fossati S., Cipriani G., Ballerini C., Biagioli T., Pimpinelli N., Borgognoni L., Massacesi L., Moroni F. and Chiarugi A. (2007). Requirement for PARP-1 activity during human dendritic cell maturation. J. Immunol. 179: 305-12.
76. D’Alfonso S., Bolognesi E., Guerini F., Barizzone N., Bocca S., Castelli L., Bergamaschi L., Agliardi C., Ferrante P., Naldi P., Leone M., Caputo D., Ballerini C., Salvetti M., Galimberti D., Massacesi L., Trojano M., Momigliano-Richiardi P. (2008). A sequence variation in the MOG gene is involved in Multiple Sclerosis susceptibility in Italy. Genes and Immun 9: 7-15.
77. Luccarini I., Ballerini C., Biagioli T., Biamonte F., Bellucci A., Rosi M.C., Grossi C., Massacesi L. and Casamenti F. (2008). Combined treatment with atorvastatin and minocycline suppresses severity of EAE. Exp. Neurol., 211: 214.
78. Mazzanti B., Aldinucci A., Biagioli T., Barilaro A., Urbani S., Dal Pozzo S., Amato MP, Siracusa GF., Crescioli C., Manuelli A., Bosi A., Saccardi R., Massacesi L. and Ballerini C. (2008). Differences in mesenchymal stem cell cytokine profiles between MS patients and healthy donors: Implication for assessment of disease activity and treatment. J. Neuroimmunol. 199:142-50.
79. ’t Hart B. and Massacesi L(2009). Clinical, pathological and immunological aspects of the multiple sclerosis model in common marmosets (Callithrix jacchus). J. Neuropath.Exp.Neurol. 68 (4): 341-355.
80. Bizzoco E, Lolli F, Repice A, Falcini M, Taiuti R, Siracusa GF, Amato MP, Biagioli T, Lori S, Moretti M, Vinattieri A, Nencini P, Massacesi L, Matà S. (2009). Prevalence of Neuromyelitis Optica Spectrum Disorder and Phenotype Distribution. J. Neurol. 256:1891-8
81. Aldinucci A, Biagioli T, Manuelli C, Repice A, Massacesi L, Ballerini C. (2010). Modulating dendritic cells (DC) from immunogenic to tolerogenic responses: a novel mechanism of AZA/6-MP. J. Neuroimmunol, 218:28-35.
82. Aldinucci A, Rizzetto L, Pieri L, Nosi D, Romagnoli P, Biagioli T, Mazzanti B, Saccardi R, Beltrame L, Massacesi L, Cavalieri D, Ballerini C (2010). Inhibition of Immune Synapse by Altered Dendritic Cell Actin Distribution: A New Pathway of Mesenchymal Stem Cell Immune Regulation. J. Immunol. 185:5102-10.
83. Gaitán M, SheaC, Evangelou I, Stone R, Fenton K, Bielekova B, Massacesi L, Reich D. (2011). Evo-lution of the Blood-Brain Barrier in Newly Forming Multiple Sclerosis Lesions. Ann. Neurol. 70: 22-29.
84. Snowden JA, Saccardi R, Allez M, Ardizzone S, Arnold R, CerveraR, DentonC, HawkeyC, Labopin M, Mancardi G, MartinR, MooreJJ, PasswegJ, Peters C, RabusinM, RoviraM, van Laar JM & Farge D on behalf of the EBMT Autoimmune Disease, (2011). Haematopietic stem cells transplantation (HSCT) in severe autoimmune diseases: updated guidelines of the European group for bone marrow transplantation (EBMT). Bone marrow Transplantation
85. MancardiG, Sormani M, Di Gioia M, Vuolo L, Gualandi F, Amato M, Capello E, Currò D, Uccelli A, Bertolotto A, Gasperini C, Lugaresi A, Merelli E, Meucci G, Motti L, Tola M, Scarpini E, Repice A, Massacesi L, Saccardi R. (2012) Autologous haematopoietic stem cell transplantation with an intermediate intensity conditioning regimen in multiple sclerosis: the Italian multi-centre experience. Mult Scler. J. 18: 835-842.
86. Lutterotti A, Jelcic I, Schulze C, Schippling S, Breiden P, Mazzanti B, Reinhard S, DiGioia M, Repice A, Massacesi L, Sputtek A, Salinas-Riester G, Kroeger N, Sospedra M, Saccardi R, Zander A and MartinR (2012). Gene expression and epigenetic profiling of CD34+ hematopoietic progenitor cells in multiple sclerosis patients – absence of proinflammatory signatures.Mult Scler. .
87. Saccardi R, Freedman MS, Sormani MP, Atkins H, Farge D, Griffith LM, Kraft G, Mancardi GL, Nash R, Pasquini M, Martin R, Muraro PA; European Blood and Marrow Transplantation Group; Center for International Blood and Marrow Research; HSCT in MS International Study Group (2012). A prospective, randomized, controlled trial of autologous haematopoietic stem cell transplantation for aggressive multiple sclerosis: a position paper. Mult Scler. Jun;18(6):825-34.
88. Zamboni P, Bertolotto A, Boldrini P, Cenni P, D'Alessandro R, D'Amico R, Del Sette M, Galeotti R, Galimberti S, Liberati A, Massacesi L, Papini D, Salvi F, Simi S, Stella A, Tesio L, Valsecchi MG, Filippini G. (2012). Efficacy and safety of venous angioplasty of the extracranial veins for multiple sclerosis. Brave Dreams Study (Brain Venous Drainage Exploited Against Multiple Sclerosis): study protocol for a randomized controlled trial. Trials 13: 183-196.
89. Carrai V, Donnini I, Mazzanti B, Alterini R, Amato MP, Barilaro A, Bosi A, Massacesi L, Portaccio E, Repice AM, Rotunno G and Saccardi R. (2013).Immunohistochemistry analysis of bone marrow biopsies in multiple sclerosis patients undergoing autologous hematopoietic stem cells transplantarion. Clin. Neurol. and Neurosurg. 115: 1044 – 1048
90. Aldinucci A, Turco A, Biagioli T, Toma F, Bani D, Guasti D, Manuelli C, Rizzetto L, Cavalieri D, Massacesi L, Mello T, Scaini D, Bianco A, Ballerini L, Prato M, Ballerini C (2013). Carbon nanotube scaffolds instruct human dendritic cells: modulating immune responses by contacts at the nanoscale. Nano Letters 13(12):6098-105.
91. Paganini M, Biggeri A, Romoli AM, Mechi C, Ghelli E, Berti V, Pradella S, Bucciantini S, Catelan D, Saccardi R, Lombardini L, Mascalchi M, Massacesi L, Porfirio B, Di Lorenzo N, Vannelli GB, Gallina P (2014). Foetal striatal grafting slows motor and cognitive decline of Huntington’s disease. J.Neurol.Neurosurg.Psich. 85: 974-981.
92. Mascalchi M, Ginestroni A, Toschi N, Poggesi A, Cecchi P, Salvadori E,Tessa C, Cosottini M,De Stefano N, Pracucci G,Pantoni L, Inzitari D, Diciotti S and VMCI Tuscany investigators. (2014).
93. The burden of microstructural damage modulates cortical activation in elderly subjects with MCI and leuko-araiosis. A DTI and fMRI study. Human Brain Mapping35: 819–830.
94. Gaitan M, Maggi P, Wholer N, Leibowitch M, Sati P, Calandri B, Merkle L, Massacesi L, Silva A, Jacobson S, Rech D. (2014) Perivenular Brain lesions in a primate multiple sclerosis model at 7-tesla MRI. Mult. Scler. 20(1):64–71.
95. Maggi P, Cummings Macri S, Gaitán M, Leibovitch E, Wohler J, Knight H, Ellis M, Wu T, Silva A, Massacesi L, Jacobson S, Westmoreland S, Reich D (2014). The formation of inflammatory demyelinated lesions in cerebral white matter. Ann. Neurol. 76:594-608.
96. Massacesi L, Tramacere I, Amoroso S, Battaglia M, Benedetti MD, Filippini G, La Mantia L, Repice A M, Solari A, Tedeschi G, Milanese C (2014). Azathioprine versus Beta Interferons for relapsing-remitting multiple sclerosis: a multicentre randomized non-inferiority trial. PlosOne, 9(11):e113371; e-Pub, November 17 2014.
97. Bonechi E, Aldinucci A, Mazzanti B., DiGioia M, Repice A, Manuelli C, Saccardi R, Massacesi L, Ballerini C, (2014). Increased CXCL10 expression in Multiple Sclerosis MSCs and monocytes is unaffected by AHSCT. Ann Clin Transl Neurol, 1:650-8.
98. Laroni A, Brogi D, Morra VB, Guidi L, Pozzilli C, Comi G, Lugaresi A, Turrini R, Raimondi D, Uccelli A, Mancardi GL, EAP Investigators (2014). Safety of the first dose of fingolimod for multiple sclerosis: results of an open-label clinical trial. BMC Neurol. 14:65.
99. Gallina P, Paganini M, Lombardini L, Biggeri A, Marini M, Morelli AM, Bucciantini S, Sarchielli E, Ambrosini S, Mechi C, Romoli AM, Ghelli E, Pradella S, Urbani S, Mazzanti B, Berti V, Giordano GP, Campolo M, Dal Pozzo S, Piacentini S, Saccardi R, Massacesi L, Mascalchi M, Bosi A, Conti R, Porfirio B, Di Lorenzo N, Vannelli GB,(2014). Trapianto intracerebrale di striato fetale nella malattia di Huntington: un aggiornamento dell'esperienza clinica italiana. Trapianti 18: 5-11.
100. Salvadori E1, Poggesi A1, Valenti R1, Pracucci G1, Pescini F2, Pasi M1, Nannucci S1, Marini S1, Del Bene A1, Ciolli L1, Ginestroni A3, Diciotti S4, Orlandi G5, Di Donato I6, De Stefano N6, Cosottini M7, Chiti A5, Federico A6, Dotti MT6, Bonuccelli U5, Inzitari D1, Pantoni L8; VMCI-Tuscany Study Group. VMCI-Tuscany Study Group (2015). Development and psychometric properties of a neuropsychological battery for mild cognitive impairment with small vessel disease: the VMCI-Tuscany Study. J Alzheimers Dis. 43: 1313-23.
101. Maggi P, Mazzoni L, Moretti M, MassacesiL (2015). SWI enhances vein detection using gadolinium in multiple sclerosis. Acta Radiologica Open. 4:2047981614560938.
102. Clausi V, Giannecchini S,Magnani E, Repice A, Mechi C, Martelli F, Azzi A, Massacesi L. (2015).Markers of JC Virus Infection in Multiple Sclerosis Patients Under Natalizumab Therapy. Neurology Neuroimmunol Neuroinflamm. 2: e58.
103. Mancardi GL, Sormani MP, Gualandi F, Saiz A, Carreras E, Merelli E, Donelli A, Lugaresi A, Di Bartolomeo P, Rottoli MR, Rambaldi A, Amato MP, Massacesi L, Di Gioia M, Vuolo V, Currò D, Roccatagliata L, Filippi M, Aguglia U, Iacopino P, Farge D, and Saccardi R. (2015). Autologous Haematopoietic Stem Cell Transplantation in Multiple Sclerosis: a phase II trial. Neurology. 84(10):981-8.
104. Giovannelli I, Martelli F, Repice AM, Massacesi L, Azzi A and Giannecchini S (2015). Detection of JCPyV microRNA in Blood and urine samples of multiple sclerosis patients under natalizumab therapy. J. of Neurovirology, 21: 666-70.
105. Capobianco M, Lo Re M, Sangalli F, Moiola L, Perini P, Gallo P, Danni M, Provinciali L, Repice AM, Massacesi L, Messina S, Patti F, Laroni A, Mancardi GL, Pucci E, Calabrese M and Bertolotto A (2015). Cyclophosphamide Pulse Therapy after Natalizumab Discontinuation for Multiple Sclerosis: a multicenter study. J Mult Scler (Foster City) 2:151.
106. Maggi P, Sati P, Massacesi L. (2016). Magnetic resonance imaging of experimental autoimmune encephalomyelitis in the common marmoset. J Neuroimmunol. 304:86-92¸ Epub 2016 Oct 8.
107. Lagi F, Bartalesi F, Pecile P, Biagioli T, Caldini AL, Fanelli A, Giannazzo G, Grifoni S, Massacesi L, Bartoloni A, Rossolini GM. (2016). Proposal for a New Score-Based Approach To Improve Efficiency of Diagnostic Laboratory Workflow for Acute Bacterial Meningitis in Adults. J Clin Microbiol. 54(7):1851-4.
108. Montanari E, Rottoli M, Maimone D, Confalonieri P, Plewnia K, Frigo M, Francia A, Pala A, Losignore NA, Ragonese P, Veneziano A; POSIDONIA study group. (2016). A 12-month prospective, observational study evaluating the impact of disease-modifying treatment on emotional burden in recently-diagnosed multiple sclerosis patients: The POSIDONIA study. J Neurol Sci. 15;364:105-9.
109. Salvadori E, Poggesi A, Valenti R, Pracucci G, Pescini F, Pasi M, Nannucci S, Marini S, Del Bene A, Ciolli L, Ginestroni A, Diciotti S, Orlandi G, Di Donato I, De Stefano N, Cosottini M, Chiti A, Federico A, Dotti MT, Bonuccelli U, Inzitari D, Pantoni L; VMCI-Tuscany Study Group (2016). Operationalizing mild cognitive impairment criteria in small vessel disease: the VMCI-Tuscany Study. Alzheimers Dement. 2016 Apr;12(4):407-18.
110. Sati P, Oh J, Constable RT, Evangelou N, Guttmann CR, Henry RG, Klawiter EC, Mainero C, Massacesi L, McFarland H, Nelson F, Ontaneda D, Rauscher A, Rooney WD, Samaraweera AP, Shinohara RT, Sobel RA, Solomon AJ, Treaba CA, Wuerfel J, Zivadinov R, Sicotte NL, Pelletier D, Reich DS; NAIMS Cooperative (2016).The central vein sign and its clinical evaluation for the diagnosis of multiple sclerosis: a consensus statement from the North American Imaging in Multiple Sclerosis Cooperative. Nat Rev Neurol. 12:714-722.
111. Cadavid D, Balcer L, Galetta S, Aktas O, Ziemssen T, Vanopdenbosch L, Frederiksen J, Skeen M, Jaffe GJ, Butzkueven H, Ziemssen F, Massacesi L, Chai Y, Xu L, Freeman S; RENEW Study Investigators (2017). Safety and efficacy of opicinumab in acute optic neuritis (RENEW): a randomised, placebo-controlled, phase 2 trial. Lancet Neurol. 16:189-199.
112. Muraro P, Pasquini M, Atkins HL, Bowen JD, Farge D, Fassas A, Freedman MS, Georges GE, Gualandi F, Hamerschlak N, Havrdova E, Kimiskidis VK, Kozak T, Mancardi GL, Massacesi L, Moraes DA, Nash RA, Pavletic S, Ouyang J, Rovira M, Saiz A, Simoes B, Trnený M, Zhu L, Badoglio M, Zhong X, Sormani MP, Saccardi R. Multiple Sclerosis–Autologous Hematopoietic Stem Cell Transplantation (MS-AHSCT) Long-term Outcomes Study Group (2017). Long-term Outcomes After Autologous Hematopoietic Stem Cell Transplantation for Multiple Sclerosis. JAMA Neurol. 74:459-469.
113. Forci B, Mariottini A, Mechi C, Massacesi L, Repice A. (2017).Disease reactivation following fingolimod withdrawal in multiple sclerosis: Two case reports. Mult Scler Relat Disord. 2017 Jul;15:24-26.
114. ZamboniP, TesioL, GalimbertiS, Massacesi L, SalviF, D’AlessandroR, CenniP, GaleottiR, PapiniD,D’AmicoR, SimiS, ValsecchiMG, FilippiniG and the Brave Dreams Research Group (2017). Efficacy and safety of extracranial vein angioplasty in multiple sclerosis: a randomized clinical trial. JAMA Neurol., e-pub 18 Novembre 2017.
115. Maggi P, Absinta M, GrammaticoM, Vuolo L, EmmiG, Carlucci G, Spagni G, Barilaro A, Repice AM, Emmi L, Prisco D, Martinelli V, Scotti R, Sadeghi N, Perrotta G, Sati P, Dachy B, Reich DS, Filippi M, Massacesi L. (2018). The central vein sign differentiates multiple sclsrosis from CNS inflammatory vasculopathies. Ann Neurol, 83 (2), 283-294.

Other publications

Amaducci L. e Massacesi L. (1981). Modificazioni neurochimiche e prospettive di farmacologia sperimentale e clinica nella sclerosi multipla. Atti del XXII° congresso della Società Italiana di Neurologia: 197-206.
Cambi F., Massacesi L. and Amaducci L. (1982). La sclerosi multipla malattia degli anticorpi senza senso. Aggiornamento del Medico 1 (5): 39-45.
Amaducci L., Massacesi L., Guarnieri B.M. (1983). Neurochemical aspects of multiple sclerosis. In "New trends of multiple sclerosis research", Cazzullo C. L., Caputo C.L., Ghezzi A. eds., pp. 125-130.
Amaducci L., Massacesi L., Guarnieri B.M., and Cambi F. (1984). Proteases, proteases inhibitors and diseases of the nervous system. In "Neuroimmunology", Behan P.O. and Spreafico F. eds., pp. 127-148. Raven Press (New York). Massacesi L. and Amaducci L. (1986). Selective immunosuppression in multiple sclerosis, in "Virology and immunology in multiple sclerosis", Cazzullo C.L., Caputo D., Ghezzi A., Zaffaroni M. editors, pp. 147-152. Springer-Verlag (Berlin).
Massacesi L., Abbamondi A.L., Castigli E., Sarlo F. and Amaducci L.(1987). Encefalomielite allergica sperimentale e acido retinoico. In "La neuroimmunologia clinica oggi", Annunziata P. and Guazzi G. eds.: 47-56, Piccin (Padova).
Massacesi L., Abbamondi A.L., Sarlo F. and Amaducci L. (1987). The control of experimental allergic encephalomyelitis with retinoic acid. Further studies. Riv. Neurol. 57:166-169.
Massacesi L., Abbamondi A.L., Castigli E. and Amaducci L. (1988). Immunosuppression in experimental allergic encephalomyelitis. In "A multidisciplinary approach to myelin diseases", Serlupi Crescenzi G. ed. Plenum Press (New York) pp. 251-258.
Massacesi L., Abbamondi A.L., Castigli E., Sarlo F. and Amaducci L. (1988). Immunohistochemical study of the suppressive effect of retinoic acid (RA) on experimental allergic encephalomyelitis. In "Trends in European multiple sclerosis research", Confavreux C., Aimard G. and Devic M. eds. Excerpta Medica (Amsterdam), pp. 147-152.
Massacesi L., Abbamondi A.L., Sarlo S., Castigli E., Olivotto J., Vergelli M. and Amaducci L. (1989). Role of astroglial cells in experimental allergic encephalomyelitis. In “Trends in neuroimmunology”, Marrosu M.G., Cianchetti C. and Tavolato B. eds., Plenum Press (New York), pp. 97-102.
Massacesi L., Sarlo F., Abbamondi A.L., Castigli E., Olivotto J., Vergelli M., Raimondi L., Medica A. and Amaducci L. (1989). Immunosuppressive activity of Retinoic Acid (RA). In “Multiple Sclerosis Research”, M.A. Battaglia ed., Elsevier Science Publishers B.V., pp. 215-224.
Massacesi L., Sarlo F., Castigli E., Vergelli M., Olivotto J., Raimondi L., Medica A. and Amaducci L. (1989). Concentration related effects of Retinoic Acid on lymphoproliferative response in EAE. In “Recent advances in multiple sclerosis therapy”, R.E. Gonsette, P. Delmotte, eds., Elsevier Science Publishers B.V., pp. 377-378.
Massacesi L., Sarlo F., Castigli E., Olivotto J., Vergelli M., Abbamondi A.L. and Amaducci L. (1989). Effects of retinoic acid on passive transfer EAE. In “Recent advances in multiple sclerosis therapy”, R.E. Gonsette, P. Delmotte, eds., Elsevier Science Publishers B.V., pp. 195-198.
Zehetbauer B., Massacesi L., Liuzzi G. M., Vergelli M., Olivotto J., Grassi L., Riccio P. and Amaducci L. (1991). Myelin Basic Protein in lipid-bound form induces experimental allergic encephalomyelitis and demyelination in Lewis rat. Acta Neurologica 13: 121-132.
Vergelli M., Sorrentino G. and Massacesi L. (1993). Malattie degenerative. In “Neuroimmunologia Clinica”, Bruno Tavolato ed. Il pensiero Scientifico ed. (Roma), pp. 213-228.
Massacesi L., Amato M.P. and Amaducci L. (1994). Immunosuppression in Multiple Sclerosis: state of the art and future perspectives. In "A multidisciplinary approach to myelin diseases. II", S. Salvati ed. Plenum Press (New York), pp. 255-259.
Fonda C., Amato M.P., Massacesi L., Falcini M. Bartolozzi L. and Amaducci L. (1995). Confronto fra RM dopo somministrazione di gadolinio, senza e dopo applicazione del “trasferimento di magnetizzazione” nella sclerosi multipla. In “Neuroradiologia”, L.Bozzao editor, Centauro (Udine), pp.273-280.
Massacesi L. (1996). L’encefalomielite autoimmune sperimentale. In “Neurobiologia e Neuroimmunologia Clinica”, a cura di Federico A. e Annunziata P. CIC edizioni Internazionali (Roma), pp 85-93.
Amato M.P., Massacesi L. and Amaducci L. (1996). Clinical outcome measurements in Multiple Sclerosis trials. MS Forum. Int. MS Journal 3 n(1) : 19-27.
Mazzanti B., Traggiai E., Hemmer B., Martin R., Massacesi L., Vergelli M. (1999). The affinity spectrum of myelin basic protein reactive T cells. In “Advances in the immunopathogenesis of multiple sclerosis”. Gambi D., Muraro P.A.and Lugaresi A. eds. Sprinter (Milano, Italy), pp 3-10.
Vergelli M., Massacesi L., McFarland H. (2000). Immunopathogenesis of Multiple Sclerosis In “T cell autoimmunity in Multiple Sclerosis”. M. Londei ed., Landes Bioscience (Georgetown, Texas, USA), pp.133-148.
Massacesi L. (2000). Patogenesi della sclerosi multipla: meccanismo di cronicizzazione delle lesioni infiammatorie. In “Aspetti Immunologici e Terapeutici della Sclerosi Multipla”- C. Fieschi ed., UTET Periodici Scientifici (Milano), pp. 2-6.
Massacesi L. (2000). Correlati biologici e di laboratorio della patologia neuroimmune. In Atti del Convegno “Impiego delle Immunoglobuline E.V. in neurologia: attualità e prospettive”.
Mancardi GL, Murialdo A, Saccardi R, Pagliai F, Gualandi F, Marmont A, Inglese M, Bruzzi P, Sormiani MP, Filippi, M., Marrosu M.G., Meucci G., Massacesi L, Bertolotto A, Lugaresi A., Morelli E., Filippi M e l’Italian GITMO-NEURO Intergroup sul Trapiantato Autologo di cellule staminali ematopoietiche nella sclerosi multipla(2005). Il trapianto autologo di midollo osseo Intensa immunosoppressione seguita da trapianto autologo di cellule staminali in pazienti con forma grave di SM: dati clinici e RM. In L’interferone beta ed altre possibilità terapeutiche. L Durelli Ed., Excerpta Medica Elsevier (Milano), pp 97-106.
Mancardi G.L., R. Saccardi, A. Murialdo, F. Pagliai, F. Gualandi, A. Marmont, M. Inglese, P. Bruzzi, M.P. Sormani, M.G. Marrosu, G. Meucci, L. Massacesi, A. Bertolotto, A. Lugaresi, E. Merelli, M. Filippi. (2007). Intense Immunosuppression Followed by Autologous Stem Cell Transplantation in Severe Multiple Sclerosis Cases: MRI and Clinical Data. In Stem Cell Therapy for Autoimmune Disease, Richard K. Burt ed.
Massacesi L. Ed. (2013). Percorsi assistenziali del paziente con Sclerosi Multipla. Maya Idee, Verona.
Massacesi L (2013). Ruolo delle Agenzie regolatorie nel percorso autorizzativo dei farmaci neurologici in Europa. Sclerosi Multipla news 4 (14): 4-7.