Clotilde Sparano, MD, PhD
Data di nascita 07/11/1989 | Nazionalità Italiana
Indirizzo: Dipartimento di Scienze Biomediche Sperimentali e Cliniche “Mario Serio”, Università degli Studi di Firenze, Viale Pieraccini 6, 50139 Firenze – Italia
POSIZIONE ATTUALE
- Dal 1° febbraio 2023 ad oggi: Ricercatore a tempo determinato di tipo A presso l’Università degli studi di Firenze, Dipartimento di Scienze Biomediche, Sperimentali e Cliniche “Mario Serio”, Progetto AGE-IT PNRR.
Attività assistenziale presso la SOD di Endocrinologia dell’Azienda Opsedaliero Universitaria di Careggi
ISTRUZIONE E FORMAZIONE
- 30 maggio 2023: Conseguimento del titolo di Dottorato di ricerca presso l’Università degli studi di Firenze con una tesi dal titolo “Dosaggio precoce della calcitonina nei pazienti affetti da carcinoma midollare tiroideo senza metastasi a distanza alla diagnosi: significato clinico e ruolo prognostico”, voto finale 70/70 cum laude
- 7 novembre 2019: Conseguimento del titolo di Specialista in Endocrinologia e Malattie del Metabolismo con una tesi dal titolo: “Lenvatinib treatment for advanced anaplastic thyroid cancer outside of clinical trials: a retrospective study from a French cohort”, voto finale 70/70 cum laude
- Dal 1° ottobre 2018 al 31 ottobre 2019: Medico presso Istituto Gustave Roussy – Université Paris Sud; Institute Gustave Roussy - Université Paris Sud, Paris, 114 Rue Edouard Vaillant 94800, Villejuif, France
- 15 ottobre 2014: Laurea in Medicina e Chirurgia presso l’Università degli studi di Perugia con una tesi dal titol: “Laser Thermoablation of Thyroid nodules”, voto finale 110/110 cum laude
COMPETENZE PERSONALI
Lingua madre: Italiano
Altre lingue: Inglese, francese (utente avanzato)
Utilizzo autonomo di programmi di statistica (SPSS, R software) e raccolta dati (REDCap)
ATTIVITÀ DIDATTICA E DI TUTORAGGIO
Attività didattica presso la Scuola di Specializzazione in Endocrinologia. Attività di tutoraggio e correlatore tesi per studenti di Medicina e della Scuola di Specializzazione presso le SOD Endocrinologia e Oncologia medica.
PRINCIPALI INCARICHI PRESSO SOCIETÀ/RIVISTE SCIENTIFICHE:
- Consigliere regionale presso la sezione Toscana della Società Italiana di Endocrinologia (SIE)
- Editor presso “Endocrinology of aging”
- Associate Editor presso “Endocrine”
- Attività di revisore per riviste nazionali ed internazionali.
PUBBLICAZIONI SELEZIONATE:
- Sparano C, Parenti G, Cilotti A, Bencini L, Calistri M, Mannucci E, Biagini C, Vezzosi V, Mannelli M, Forti G et al. 2019 Clinical impact of the new SIAPEC-IAP classification on the indeterminate category of thyroid nodules. Journal of Endocrinological Investigation 42 1–6. (doi:10.1007/s40618-018-0871-7)
- Habib G, Erba PA, Iung B, Donal E, Cosyns B, Laroche C, Popescu BA, Prendergast B, Tornos P, Sadeghpour A et al. 2019a Clinical presentation, aetiology and outcome of infective endocarditis. Results of the ESC-EORP EURO-ENDO (European infective endocarditis) registry: a prospective cohort study. European Heart Journal 40 3222–3232. (doi:10.1093/eurheartj/ehz620).
Sparano C is included among the EURO-ENDO Investigators
- Habib G, Lancellotti P, Erba P-A, Sadeghpour A, Meshaal M, Sambola A, Furnaz S, Citro R, Ternacle J, Donal E et al. 2019b The ESC-EORP EURO-ENDO (European Infective Endocarditis) registry. European Heart Journal. Quality of Care & Clinical Outcomes 5 202–207. (doi:10.1093/ehjqcco/qcz018)
- Sparano C, Godbert Y, Attard M, Do Cao C, Zerdoud S, Roudaut N, Joly C, Berdelou A, Hadoux J, Lamartina L et al. 2021a Limited efficacy of lenvatinib in heavily pretreated anaplastic thyroid cancer: a French overview. Endocrine-Related Cancer 28 15–26. (doi:10.1530/ERC-20-0106)
- Sparano C, Verdiani V, Pupilli C, Perigli G, Badii B, Vezzosi V, Mannucci E, Maggi M & Petrone L 2021b Choosing the best algorithm among five thyroid nodule ultrasound scores: from performance to cytology sparing-a single-center retrospective study in a large cohort. European Radiology. (doi:10.1007/s00330-021-07703-5)
- Corona G, Croce L, Sparano C, Petrone L, Sforza A, Maggi M, Chiovato L, Rotondi M. Thyroid and heart, a clinically relevant relationship. J Endocrinol Invest. 2021 May 25. doi: 10.1007/s40618-021-01590-9. Epub ahead of print. PMID: 34033065.
- Forleo R, Grani G, Alfò M, Zilioli V, Giubbini R, Zatelli MC, Gagliardi I, Piovesan A, Ragni A, Morelli S, Puxeddu E, Pagano L, Deandrea M, Ceresini G, Torlontano M, Puligheddu B, Antonelli A, Centanni M, Fugazzola L, Spiazzi G, Monti S, Rossetto R, Monzani F, Tallini G, Crescenzi A, Sparano C, Bruno R, Repaci A, Tumino D, Pezzullo L, Lombardi CP, Ferraro Petrillo U, Filetti S, Durante C, Castagna MG. Minimal Extrathyroidal Extension in Predicting 1-Year Outcomes: A Longitudinal Multicenter Study of Low-to-Intermediate-Risk Papillary Thyroid Carcinoma (ITCO#4). Thyroid. 2021 Sep 19. doi: 10.1089/thy.2021.0248. Epub ahead of print. PMID: 34541894.
- Perigli G, Cianchi F, Giudici F, Russo E, Fiorenza G, Petrone L, Sparano C, Staderini F, Badii B, Morandi A. Thyroidectomy for Cancer: The Surgeon and the Parathyroid Glands Sparing. J Clin Med. 2021 Sep 23;10(19):4323. doi: 10.3390/jcm10194323. PMID: 34640352; PMCID: PMC8509338.
- Sparano C, Zago E, Morettini A, Nozzoli C, Yannas D, Adornato V, Caldini E, Vaudo M, Maggi M, Petrone L. Euthyroid sick syndrome as an early surrogate marker of poor outcome in mild SARS-CoV-2 disease. J Endocrinol Invest. 2021 Dec 1:1–11. doi: 10.1007/s40618-021-01714-1. Epub ahead of print. PMID: 34850365; PMCID: PMC8632565.
- Sparano C, Maggi M, Petrone L. Response to Letter to the Editor from Lui et al.: 'Euthyroid sick syndrome as an early surrogate marker of poor outcome in mild SARS-CoV-2 disease': prognostic significance of non-thyroidal illness syndrome in the whole spectrum of COVID-19 severity. J Endocrinol Invest. 2022 Apr;45(4):903-904. doi: 10.1007/s40618-021-01733-y. Epub 2022 Jan 28. PMID: 35088382; PMCID: PMC8794622.
- Sengupta SP, Prendergast B, Laroche C, Furnaz S, Ronderos R, Almaghraby A, Asch FM, Blechova K, Zaky H, Strahilevitz J, Dworakowski R, Miyasaka Y, Sebag I, Izumi C, Axler O, Jamiel A, Philip M, Campos Vieira ML, Lancellotti P, Habib G; EURO-ENDO Investigators Group. Socio-Economic Variations Determine the Clinical Presentation, Aetiology and Outcome of Infective Endocarditis: a Prospective Cohort Study from the ESC-EORP EURO-ENDO (European Infective Endocarditis) Registry. Eur Heart J Qual Care Clin Outcomes. 2022 Mar 12:qcac012. doi: 10.1093/ehjqcco/qcac012. Epub ahead of print. PMID: 35278091.
- Pazdernik M, Iung B, Mutlu B, Alla F, Riezebos R, Kong W, Nunes MCP, Pierard L, Srdanovic I, Yamada H, De Martino A, Miglioranza MH, Magne J, Piper C, Laroche C, Maggioni AP, Lancellotti P, Habib G, Selton-Suty C; EURO-ENDO Investigators group. Surgery and outcome of infective endocarditis in octogenarians: prospective data from the ESC EORP EURO-ENDO registry. Infection. 2022 Mar 15. doi: 10.1007/s15010-022-01792-0. Epub ahead of print. PMID: 35290614.
- Bohbot Y, Habib G, Laroche C, Stöhr E, Chirouze C, Hernandez-Meneses M, Melissopoulou M, Mutlu B, Scheggi V, Branco L, Olmos C, Reyes G, Pazdernik M, Iung B, Sow R, Mirocevic M, Lancellotti P, Tribouilloy C; EORP EURO-ENDO Registry Investigators Group. Characteristics, management, and outcomes of patients with left-sided infective endocarditis complicated by heart failure: a substudy of the ESC-EORP EURO-ENDO (European infective endocarditis) registry. Eur J Heart Fail. 2022 Jul;24(7):1253-1265. doi: 10.1002/ejhf.2525. Epub 2022 May 16. PMID: 35508915.
- Della Bella C, Antico A, Panozzo MP, Capitani N, Petrone L, Benagiano M, D'Elios S, Sparano C, Azzurri A, Pratesi S, Cianchi F, Ortiz-Princz D, Bergman M, Bizzaro N, D'Elios MM. Gastric Th17 Cells Specific for H+/K+-ATPase and Serum IL-17 Signature in Gastric Autoimmunity. Front Immunol. 2022 Jul 11;13:952674. doi: 10.3389/fimmu.2022.952674. PMID: 35911678; PMCID: PMC9328118.
- Sparano C, Moog S, Hadoux J, Dupuy C, Al Ghuzlan A, Breuskin I, Guerlain J, Hartl D, Baudin E, Lamartina L. Strategies for Radioiodine Treatment: What's New. Cancers (Basel). 2022 Aug 4;14(15):3800. doi: 10.3390/cancers14153800. PMID: 35954463; PMCID: PMC9367259.
- Iorio J, Antonuzzo L, Scarpi E, D'Amico M, Duranti C, Messerini L, Sparano C, Caputo D, Lavacchi D, Borzomati D, Antonelli A, Nibid L, Perrone G, Coppola A, Coppola R, di Costanzo F, Lastraioli E, Arcangeli A. Prognostic role of hERG1 Potassium Channels in Neuroendocrine Tumours of the Ileum and Pancreas. Int J Mol Sci. 2022 Sep 13;23(18):10623. doi: 10.3390/ijms231810623. PMID: 36142530; PMCID: PMC9504580.
- Sparano C, Rotondi M, Verdiani V, Brunori P, Castiglione F, Bartoli C, et al. Classic and follicular variant of papillary thyroid microcarcinoma: two different phenotypes beyond tumour size. Journal of the Endocrine Society. 2022 Oct 13;bvac157.
- Barbonetti A, Rastrelli G, Sparano C, Castellini C, Vignozzi L, Maggi M, Corona G. Is marijuana a foe of male sexuality?: Data from a large cohort of men with sexual dysfunction. Andrology. 2023 Jan 8. doi: 10.1111/andr.13382. Epub ahead of print. PMID: 36617843.
- Grani G, Gentili M, Siciliano F, Albano D, Zilioli V, Morelli S, Puxeddu E, Zatelli MC, Gagliardi I, Piovesan A, Nervo A, Crocetti U, Massa M, Samà MT, Mele C, Deandrea M, Fugazzola L, Puligheddu B, Antonelli A, Rossetto R, D'Amore A, Ceresini G, Castello R, Solaroli E, Centanni M, Monti S, Magri F, Bruno R, Sparano C, Pezzullo L, Crescenzi A, Mian C, Tumino D, Repaci A, Castagna MG, Triggiani V, Porcelli T, Meringolo D, Locati L, Spiazzi G, Di Dalmazi G, Anagnostopoulos A, Leonardi S, Filetti S, Durante C. A Data-Driven Approach to Refine Predictions of Differentiated Thyroid Cancer Outcomes: A Prospective Multicenter Study. J Clin Endocrinol Metab. 2023 Jul 14;108(8):1921-1928. doi: 10.1210/clinem/dgad075. PMID: 36795619.
- Sparano C, Adornato V, Puccioni M, Zago E, Perigli G, Badii B, Santoro R, Maggi M, Petrone L. Early calcitonin levels in medullary thyroid carcinoma: Prognostic role in patients without distant metastases at diagnosis. Front Oncol. 2023 Feb 24;13:1120799. doi:10.3389/fonc.2023.1120799. PMID: 36910603; PMCID: PMC9998669.
- Fazio N, Gervaso L, Halfdanarson TR, Sonbol M, Eiring RA, Pusceddu S, Prinzi N, Lombardi Stocchetti B, Grozinsky-Glasberg S, Gross DJ, Walter T, Robelin P, Lombard-Bohas C, Frassoni S, Bagnardi V, Antonuzzo L, Sparano C, Massironi S, Gelsomino F, Bongiovanni A, Ranallo N, Tafuto S, Rossi M, Cives M, Rasul KI, Hamid H, Chirco A, Squadroni M, La Salvia A, Hernando J, Hofland J, Koumarianou A, Boselli S, Tamayo D, Mazzon C, Rubino M, Spada F. COVID-19 in patients with neuroendocrine neoplasms: two-year results of the INTENSIVE study. Endocr Relat Cancer. 2023 Mar 1:ERC-22-0395. doi: 10.1530/ERC-22-0395. Epub ahead of print. PMID: 36930250.
- Giudici F, Fortuna L, Russo E, Badii B, Coratti F, Staderini F, Morandi A, Sparano C, Petrone L, Cianchi F, Perigli G. Surgery for Sporadic Primary Hyperparathyroidism: Evolution over the Last Twenty Years in a Monocentric Setting. Cancers (Basel). 2023 Apr 30;15(9):2581. doi: 10.3390/cancers15092581. PMID: 37174047; PMCID: PMC10177273.
- Santi D, Lotti F, Sparano C, Rastrelli G, Isidori AM, Pivonello R, Barbonetti A, Salonia A, Minhas S, Krausz C, Vignozzi L, Maggi M, Corona G. Does an increase in adipose tissue 'weight' affect male fertility? A systematic review and meta-analysis based on semen analysis performed using the WHO 2010 criteria. Andrology. 2023 May 25. doi: 10.1111/andr.13460. Epub ahead of print. PMID: 37226894.
- Corona G, Rastrelli G, Bianchi N, Sparano C, Sforza A, Vignozzi L, Maggi M. Hyperprolactinemia and male sexual function: focus on erectile dysfunction and sexual desire. Int J Impot Res. 2023 Jun 20. doi: 10.1038/s41443-023-00717-1. Epub ahead of print. PMID: 37340146.
- De Filpo G, Parenti G, Sparano C, Rastrelli G, Rapizzi E, Martinelli S, Amore F, Badii B, Paolo P, Ercolino T, Mannelli M, Maggi M, Canu L. Hemodynamic parameters in patients undergoing surgery for pheochromocytoma/paraganglioma: a retrospective study. World J Surg Oncol. 2023 Jun 27;21(1):192. doi: 10.1186/s12957-023-03072-z. Erratum in: World J Surg Oncol. 2023 Sep 19;21(1):298. PMID: 37370080; PMCID: PMC10294368.
- Corona DG, Vena W, Pizzocaro A, Rastrelli G, Sparano C, Sforza A, Vignozzi L, Maggi M. Metabolic syndrome and erectile dysfunction: a systematic review and meta-analysis study. J Endocrinol Invest. 2023 Jul 29. doi: 10.1007/s40618-023-02136-x. Epub ahead of print. PMID: 37515706.
- Sambola A, Lozano-Torres J, Boersma E, Olmos C, Ternacle J, Calvo F, Tribouilloy C, Reskovic-Luksic V, Separovic-Hanzevacki J, Park SW, Bekkers S, Chan KL, Almaghraby A, Iung B, Lancellotti P, Habib G; ESC EORP EURO-ENDO Registry Investigator Group. Predictors of embolism and death in left-sided infective endocarditis: the European Society of Cardiology EURObservational Research Programme European Infective Endocarditis registry. Eur Heart J. 2023 Aug 18:ehad507. doi: 10.1093/eurheartj/ehad507. Epub ahead of print. PMID: 37592753.
- De Leo S, D'Elia S, Grani G, Dondi F, Bertagna F, Puxeddu E, Morelli S, Piovesan A, Nervo A, Zatelli MC, Gagliardi I, Samà MT, Aimaretti G, Crocetti U, Massa M, Deandrea M, Retta F, Pagano L, Rossi M, Solaroli E, Pezzullo L, Chiofalo MG, Pontecorvi A, Lombardi CP, Antonelli A, Patrizio A, Messuti I, Magri F, Spiazzi G, Ceresini G, Bruno R, Sparano C, Centanni M, Crescenzi A, Tallini G, Marotta V, Madeo B, Mian C, Filetti S, Durante C, Fugazzola L. A Prospective Multicenter Study Examining the Relationship Between Thyroid Cancer Treatment Outcomes and the Presence of Autoimmune Thyroiditis. Thyroid. 2023 Oct 19. doi: 10.1089/thy.2023.0052. Epub ahead of print. PMID: 37725571.
- Sparano C, Puccioni M, Adornato V, Zago E, Fibbi B, Badii B, Bencini L, Mannelli G, Vezzosi V, Maggi M, Petrone L. Improving the TIR3B oncological stratification: try to bridge the gap through a comprehensive presurgical algorithm. J Endocrinol Invest. 2023 Sep 22. doi: 10.1007/s40618-023-02182-5. Epub ahead of print. PMID: 37736856.
- Zago E, Galluzzo A, Pradella S, Antonuzzo L, Maggi M, Petrone L, Sparano C. Cabozantinib for different endocrine tumours: killing two birds with one stone. A systematic review of the literature. Endocrine. 2023 Oct 18. doi: 10.1007/s12020-023-03526-0. Epub ahead of print. PMID: 37851242.
- Corona G, Sparano C, Rastrelli G, Vignozzi L, Maggi M. Developments and challenges for new and emergent preparations for male hypogonadism treatment. Expert Opin Investig Drugs. 2023 Jul-Dec;32(11):1071-1084. doi: 10.1080/13543784.2023.2276760. Epub 2023 Nov 24. PMID: 37943011.
- Corona G, Rastrelli G, Sparano C, Vignozzi L, Sforza A, Maggi M. Advances in the treatment of functional male hypogonadism. Expert Rev Endocrinol Metab. 2024 Mar;19(2):163-177. doi: 10.1080/17446651.2023.2296022. Epub 2023 Dec 20. PMID: 38117229.
- Canu L, Sparano C, Naletto L, De Filpo G, Cantini G, Rapizzi E, Martinelli S, Ercolino T, Cioppi F, Fantoni A, Zanatta L, Terreni A, Mannelli M, Luconi M, Maggi M, Lotti F. Hypogonadism and sexual function in men affected by adrenocortical carcinoma under mitotane therapy. Front Endocrinol (Lausanne). 2024 Jan 10;14:1320722. doi: 10.3389/fendo.2023.1320722. PMID: 38269251; PMCID: PMC10807287.
- Croce L, Teliti M, Chytiris S, Sparano C, Coperchini F, Villani L, Calì B, Petrone L, Magri F, Trimboli P, Rotondi M. The American Thyroid Association risk classification of papillary thyroid cancer according to presurgery cytology. Eur J Endocrinol. 2024 Feb 1;190(2):165-172. doi: 10.1093/ejendo/lvae012. PMID: 38298148.
- Corona G, Rastrelli G, Sparano C, Carinci V, Casella G, Vignozzi L, Sforza A, Maggi M. Cardiovascular safety of testosterone replacement therapy in men: an updated systematic review and meta-analysis. Expert Opin Drug Saf. 2024 May;23(5):565-579. doi: 10.1080/14740338.2024.2337741. Epub 2024 May 6. PMID: 38553429.
- Corona G, Rastrelli G, Sparano C, Vignozzi L, Sforza A, Maggi M. Pharmacological management of testosterone deficiency in men current advances and future directions. Expert Rev Clin Pharmacol. 2024 Aug;17(8):665-681. doi: 10.1080/17512433.2024.2366505. Epub 2024 Jun 13. PMID: 38853775.
- Corona G, Rastrelli G, Sparano C, Vignozzi L, Maggi M. Acquired hypoprolactinemia in men, possible phenotype. Rev Endocr Metab Disord. 2024 Jul 27. doi: 10.1007/s11154-024-09895-9. Epub ahead of print. PMID: 39066947.
- Grani G, D'Elia S, Puxeddu E, Morelli S, Arvat E, Nervo A, Spiazzi G, Rolli N, Zatelli MC, Ambrosio MR, Ceresini G, Marina M, Mele C, Aimaretti G, Santaguida MG, Virili C, Crescenzi A, Palermo A, Giaccherino RR, Meomartino L, Castagna MG, Maino F, Trevisan M, De Leo S, Chiofalo MG, Pezzullo L, Sparano C, Petrone L, Dalmazi GD, Napolitano G, Tumino D, Crocetti U, Bertagna F, Deandrea M, Antonelli A, Mian C, Carbone A, Monti S, Porcelli T, Brigante G, Barbaro D, Alfò M, Ferraro Petrillo U, Filetti S, Durante C. Data-Driven Thyroglobulin Cutoffs for Low- and Intermediate-Risk Thyroid Cancer Follow-Up: ITCO Real-World Analysis. J Clin Endocrinol Metab. 2024 Aug 16:dgae559. doi: 10.1210/clinem/dgae559. Epub ahead of print. PMID: 39150986.
- Sparano C, Rastrelli G, Corona G, Vignozzi L, Vignoli D, Maggi M. Age disparity in couples and the sexual and general health of the male partner. Andrology. 2024 Aug 19. doi: 10.1111/andr.13738. Epub ahead of print. PMID: 39158122.
Legenda
Birth date 07/11/1989 | Nationality: Italian
Business address: Dept. Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Viale Pieraccini 6, 50139 Florence – Italy
CURRENT POSITION
- From February 1° 2023 to present: Clinical researcher fellow in Endocrinology (RTDA) University of Florence, project AGE-IT PNRR.
SODC Endocrinology Careggi University Hospital, Florence, Italy.
EDUCATION
- 2023: PhD in Biomedical Sciences: 70/70 cum laude. PhD thesis: “Dosaggio precoce della calcitonina nei pazienti affetti da carcinoma midollare tiroideo senza metastasi a distanza alla diagnosi: significato clinico e ruolo prognostico”
- 2019: Specialization in Endocrinology: 70/70 cum laude. Thesis: “Lenvatinib treatment for advanced anaplastic thyroid cancer outside of clinical trials: a retrospective study from a French cohort”
- From October 1st 2018 to October 31th 2019: MD at Gustave Roussy Institute– Université Paris Sud; Institute Gustave Roussy - Université Paris Sud, Paris, 114 Rue Edouard Vaillant 94800, Villejuif, France
- 2014: Degree in Medicine and surgery at University of Perugia: 110/110 cum laude. Thesis: “Laser Thermoablation of Thyroid nodules”
PERSONAL SKILLS
Foreign languages: English, French (advanced user)
Autonomous user of several statistical and collection data software (SPSS, R software, REDCap)
TEACHING ACTIVITY
Teaching activity at the School of Endocrinology of the University of Florence. Tutoring activity for undergraduate students of Medicine and Surgery and supervisor/mentor of thesis.
MAIN ROLES IN SCIENTIFIC ORGANIZATIONS/JOURNALS
- Tuscany regional councillor for the Italian Endocrinology Society (SIE)
- Editor for “Endocrinology of aging” journal
- Associate Editor for “Endocrine” journal
- Reviewer for several scientific journals
SELECTED PUBBLICATIONS