Dina SCARPI

Ruolo attuale:: Ricercatore
SSD:: CHEM-05/A - Chimica organica
Afferenza organizzativa:: Dipartimento di Chimica 'Ugo Schiff' - DICUS

Recapiti

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	dina.scarpi(AT)unifi.it

Ulteriori Recapiti

http://www.unifi.it/dipchimica/CMpro-v-p-257.html

Dina SCARPI

Orario di ricevimento (aggiornato al 29/08/2022)

Sempre disponibile a ricevere gli studenti, previo accordo telefonico o via e-mail.

Dina SCARPI

Biografia

1995 Laurea in Chimica (Università degli Studi di Firenze)

1996 Borsista (programma Vigoni, scambio di ricercatori Italia-Germania) al Dipartimento di Chimica Farmaceutica dell'Universität des Saarlandes (Saarbrücken, D).

1997-1999 Dottorato di ricerca in Scienze Chimiche (XII Ciclo) presso l'Università degli Studi di Firenze.

2000-2001: Research Associate al Department of Chemistry dell'Imperial College of Science Technology and Medicine (London, UK).

2002-2005: Borsista presso il Dipartimento di Chimica Organica e la Facoltà di Scienze Matematiche, Fisiche e Naturali dell'Università degli Studi di Firenze.

2005-2009: Ricercatore a tempo determinato.

Dal 2009 ad oggi: Ricercatore a tempo indeterminato (Università degli Studi di Firenze).

Dina SCARPI

Curriculum

Laurea in Chimica nel 1995, presso l'Università di Firenze. Dopo uno stage tecnico presso la Procter & Gamble (Roma), svolge attività di ricerche per conto della Menarini S.p.A. presso il Dipartimento di Chimica Organica dell'Università di Firenze e collabora con il Dipartimento di Fisiopatologia Clinica, Unità di Endocrinologia. Nel 1996 si reca presso il Dipartimento di Pharmazeutische Chemie dell'Universität des Saarlandes, (Saarbrücken, D), nell'ambito del programma di scambio di ricercatori fra Italia e Germania. Nel 1997 inizia il corso di Dottorato di ricerca in Scienze Chimiche (XII Ciclo, 1997-1999), presso l'Università di Firenze e consegue il titolo agli inizi del 2000. Durante il corso di dottorato svolge parte della sua ricerca presso i laboratori dell'Azienda Farmaceutica Serono Inc. (Boston, USA) e presso il Dept of Chemistry dellImperial College of Science Technology and Medicine (London, UK), dove lavorerà dal 2000 in qualità di Research Associate. Rientrata all'Università di Firenze, nel 2002 ottiene un finanziamento alla ricerca con il Progetto Giovani Ricercatori, istituito dal MURST, e svolge attività sia di ricerca che didattica presso il Dipartimento di Chimica Organica e presso la Facoltà di Scienze Matematiche, Fisiche e Naturali. Nel 2005 viene assunta come ricercatore a tempo determinato e dal 2009 è ricercatore di ruolo.

Dina SCARPI

Interessi

Sintesi organica mediante sia tecniche classiche che biotrasformazioni e sua applicazione alla medicinal chemistry; studio della relazione struttura-attività di inibitori di enzimi e ligandi recettoriali; sintesi di prodotti naturali; sviluppo di nuovi leganti chirali e loro impiego in reazioni enantioselettive metallo-catalizzate.

Dina SCARPI

Pubblicazioni

Legenda

Contributo su rivista |

Articolo su libro |

Libro |

Contributo in atti di convegno (proceeding) |

Brevetto |

Curatela | Altro

Altro |

Tesi di Dottorato

Arnodo, Davide; De Nardi, Federica; Parisotto, Stefano; De Nardo, Eugenio; Cananà, Stefania; Salvatico, Federica; De Marchi, Elisa; Scarpi, Dina; Blangetti, Marco; Occhiato, Ernesto G.; Prandi, Cristina (2024). Asymmetric Reduction of Cyclic Imines by Imine Reductase Enzymes in Non‐Conventional Solvents. CHEMSUSCHEM, vol. 17, pp. 0-0, ISSN:1864-5631 DOI

Scarpi, Dina; Capanni, Claudia; Visi, Samuele; Faggi, Cristina; Occhiato, Ernesto G. (2024). Gold(I)-Catalyzed Rautenstrauch/Hetero-Diels–Alder/Retro-aza-Michael Cascade Reaction for the Synthesis of α-Hydrazineyl-2-cyclopentenones. JOURNAL OF ORGANIC CHEMISTRY, vol. 89, pp. 14108-14119, ISSN:0022-3263 DOI

Scarpi, Dina; Favale, Nunzia; Occhiato, Ernesto G (2023). Synthesis of 5-Hydrazino-2-cyclopentenone Derivatives by a Gold(I)-Catalyzed Cycloisomerization/Hetero-Diels-Alder/Ring-Opening Tandem Reaction of Enynyl Acetates. JOURNAL OF ORGANIC CHEMISTRY, vol. 88, pp. 7015-7025, ISSN:1520-6904 DOI

Scarpi D.; Bagni F.; Faggi C.; Carral-Menoyo A.; Gomez-Bengoa E.; Occhiato E.G. (2022). Gold(I)-Catalyzed Cycloisomerization/Hetero-Diels-Alder Reaction/Ring Opening Cascade to Functionalized Cyclopentadienes. JOURNAL OF ORGANIC CHEMISTRY, vol. 87, pp. 6038-6051, ISSN:0022-3263 DOI

Rinaldi A.; Lange V.; Scarpi D.; Occhiato E.G. (2021). Synthesis of (±)-epi-Jungianol by the Gold(I)-Catalyzed Propargyl Claisen Rearrangement/Hydroarylation Cascade Reaction of Propargyl Vinyl Ethers. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2021, pp. 1266-1273, ISSN:1434-193X DOI Accesso ONLINE all'editore

De Marchi E.; Arnodo D.; Maffeis E.; Scarpi D.; Prandi C.; Occhiato E.G. (2021). Enantiodivergent Synthesis of Halofuginone by Candida antarctica Lipase B (CAL-B)-Catalyzed Kinetic Resolution in Cyclopentyl Methyl Ether (CPME). SYNOPEN, vol. 5, pp. 145-151, ISSN:2509-9396 DOI Accesso ONLINE all'editore

Dordoni F.; Scarpi D.; Bianchini F.; Contini A.; Occhiato E.G. (2020). Enantioselective Synthesis of cis and trans 4-Aminopipecolic Acids as γ-Amino Acids for the Construction of Cyclic RGD-Containing Peptidomimetics Antagonists of αVβ3 Integrin. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2020, pp. 4371-4383, ISSN:1434-193X DOI

Zanella G.; Petrovic M.; Scarpi D.; Occhiato E.G.; Gomez-Bengoa E. (2020). Pentannulation of N-heterocycles by a tandem gold-catalyzed [3,3]-rearrangement/Nazarov reaction of propargyl ester derivatives: A computational study on the crucial role of the nitrogen atom. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, vol. 16, pp. 3059-3068, ISSN:1860-5397 DOI

Rinaldi A.; Lange V.; Scarpi D.; Occhiato E.G. (2020). One-Pot Access to 1,7a-Dihydro-1,3a-ethano-indene and 1,8a-Dihydro-1,3a-ethano-azulene Skeletons by a Sequential Gold(I)-Catalyzed Propargyl Claisen Rearrangement/Nazarov Cyclization/[4+2] Cycloaddition Reaction. JOURNAL OF ORGANIC CHEMISTRY, vol. 85, pp. 5078-5086, ISSN:0022-3263 DOI

Nejrotti S.; Ghinato S.; Gini E.C.; Scarpi D.; Occhiato E.G.; Maranzana A.; Prandi C. (2020). Gold(I)-Catalysed Hydroarylation of Lactam-Derived Enynes as an Entry to Tetrahydrobenzo[g]quinolines. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2020, pp. 646-653, ISSN:1434-193X DOI Accesso ONLINE all'editore

Rinaldi, Antonia; Langé, Vittoria; Gómez-Bengoa, Enrique; Zanella, Giovanna; Scarpi, Dina; Occhiato, Ernesto G (2019). Synthesis of Indenes by Tandem Gold(I)-Catalyzed Claisen Rearrangement/Hydroarylation Reaction of Propargyl Vinyl Ethers. JOURNAL OF ORGANIC CHEMISTRY, vol. 84, pp. 6298-6311-6311, ISSN:0022-3263 DOI

Rinaldi A.; Scarpi D.; Occhiato E.G. (2019). Recent Advances in the Synthesis of Indenes. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2019, pp. 7401-7419, ISSN:1434-193X DOI Accesso ONLINE all'editore

Petrović, Martina; Rinaldi, Antonia; Occhiato, Ernesto G.; Scarpi, Dina (2018). Short synthesis of racemic 5-hydroxy-6-hydroxymethylpiperidin-2-one. CHEMICAL DATA COLLECTIONS, vol. 13-14, pp. 11-16, ISSN:2405-8300 DOI Accesso ONLINE all'editore

Rinaldi, Antonia; Petrović, Martina; Magnolfi, Stefano; Scarpi, Dina; Occhiato, Ernesto G (2018). Pentannulation Reaction by Tandem Gold(I)-Catalyzed Propargyl Claisen Rearrangement/Nazarov Cyclization of Enynyl Vinyl Ethers. ORGANIC LETTERS, vol. 20, pp. 4713-4717, ISSN:1523-7060 DOI Accesso ONLINE all'editore

Sernissi, Lorenzo; Ricci, Luciano; Scarpi, Dina; Bianchini, Francesca; Arosio, Daniela; Contini, Alessandro*; Occhiato, Ernesto G. (2018). Stereodivergent synthesis of 5-aminopipecolic acids and application in the preparation of a cyclic RGD peptidomimetic as a nanomolar αvβ3 integrin ligand. ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 16, pp. 3402-3414, ISSN:1477-0520 DOI Accesso ONLINE all'editore

Ricci, Luciano; Sernissi, Lorenzo; Scarpi, Dina; Bianchini, Francesca; Contini, Alessandro; Occhiato, ERNESTO GIOVANNI (2017). Synthesis and conformational analysis of peptides embodying 2,3-methanopipecolic acids. ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 15, pp. 6826-6836, ISSN:1477-0520 DOI Accesso ONLINE all'editore

Petrovic, Martina; Scarpi, Dina; Nieger, Martin; Jung, Nicole; Occhiato, Ernesto G.; Brase, Stefan; (2017). Oxidation of diazenyl-protected N-heterocycles – a new entry to functionalized lactams. RSC ADVANCES, vol. 7, pp. 9461-9464, ISSN:2046-2069 DOI

Scarpi, Dina; Faggi, Cristina; Occhiato, Ernesto G (2017). Total Synthesis of Bruceolline I. JOURNAL OF NATURAL PRODUCTS, vol. 80, pp. 2384-2388, ISSN:0163-3864 DOI Accesso ONLINE all'editore

Stefano, Nejrotti; Gabriele Prina Cerai, ; Alberto, Oppedisano; Andrea, Maranzana; Occhiato, ERNESTO GIOVANNI; Scarpi, Dina; Annamaria, Deagostino; Cristina, Prandi (2017). A Gold(I)-Catalyzed Oxidative Rearrangement of Heterocycle-Derived 1,3-Enynes Provides an Efficient and Selective Route to Divinyl Ketones. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, pp. 6228-6238, ISSN:1434-193X DOI Accesso ONLINE all'editore

Sernissi, Lorenzo; Trabocchi, Andrea; Scarpi, Dina; Bianchini, Francesca; Occhiato, Ernesto G. (2016). Cyclic RGD peptidomimetics containing 4- and 5-aminocyclopropane pipecolic acid (CPA) templates as dual aVb3 and a5b1 integrin ligands. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 24, pp. 703-711, ISSN:1464-3391 DOI

Scarpi, Dina; Petrović, Martina; Fiser, Béla; Gómez-Bengoa, Enrique; Occhiato, Ernesto G. (2016). Construction of Cyclopenta[b]indol-1-ones by a Tandem Gold(I)-Catalyzed Rearrangement/Nazarov Reaction and Application to the Synthesis of Bruceolline H. ORGANIC LETTERS, vol. 18, pp. 3922-3925, ISSN:1523-7060 DOI Accesso ONLINE all'editore

Sernissi, Lorenzo; Petrovic, Martina; Scarpi, Dina; Trabocchi, Andrea; Bianchini, Francesca; Occhiato, Ernesto Giovanni (2015). Cyclopropane pipecolic acids as templates for linear and cyclic peptidomimetics. AMINO ACIDS, vol. 47, pp. 1647-1647, ISSN:0939-4451 DOI

Petrović, Martina; Scarpi, Dina; Fiser, Béla; Gómez-Bengoa, Enrique; Occhiato, Ernesto G. (2015). Annulated N-Heterocycles by Tandem Gold(I)-catalyzed [3,3]-Rearrangement/Nazarov Reaction of Propargylic Ester Derivatives: an Experimental and Computational Study. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, pp. 3943-3956, ISSN:1099-0690 DOI Accesso ONLINE all'editore

Dina Scarpi; Stefano Begliomini; Cristina Prandi; Alberto Oppedisano; Annamaria Deagostino; Enrique Gómez-Bengoa; Béla Fiser; Ernesto G. Occhiato (2015). Gold-catalyzed Synthesis of Exocyclic Vinylogous Amides and beta-Amino Ketones. A Detailed Study on the 5-exo/6-endo dig Selectivity, Methodology and Scope. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2015, pp. 3251-3265, ISSN:1099-0690 DOI Accesso ONLINE all'editore

Artuso, Emma; Ghibaudi, Elena; Lace, Beatrice; Marabello, Domenica; Vinciguerra, Daniele; Lombardi, Chiara; Koltai, Hinanit; Kapulnik, Yoram; Novero, Mara; Occhiato, Ernesto G.; Scarpi, Dina; Parisotto, Stefano; Deagostino, Annamaria; Venturello, Paolo; Mayzlish-Gati, Einav; Bier, Ariel; Prandi, Cristina (2015). Stereochemical Assignment of Strigolactone Analogues Confirms Their Selective Biological Activity. JOURNAL OF NATURAL PRODUCTS, vol. 78, pp. 2624-2633, ISSN:0163-3864 DOI Accesso ONLINE all'editore

C. Prandi; G. Ghigo; E. Occhiato; D. Scarpi; S. Begliomini; B. Lace; G. Alberto; E. Artuso; M. Blangetti (2014). Tailoring Fluorescent Strigolactones for in vivo Investigations: a computational and experimental study. ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 12, pp. 2960-2968, ISSN:1477-0520 DOI Accesso ONLINE all'editore

Stefano Begliomini; Lorenzo Sernissi; Dina Scarpi;Ernesto G. Occhiato (2014). A Short, Chemo-Enzymatic Synthesis of Both Enantiomers of trans-3-Hydroxypipecolic Acid. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2014, pp. 5448-5455, ISSN:1434-193X DOI Accesso ONLINE all'editore

D. Scarpi; E. G. Occhiato (2014). Synthesis of heterocycles: from simple to complex structures in the golden age of catalysis. In: XXXIX "A. Corbella" International Summer School, Gargnano, 15-19/06/2014, Società Chimica Italiana. Divisione di Chimica Organica, pp. 54-77, ISBN:9788886208765

Lorenzo Sernissi; Martina Petrovic; Dina Scarpi; Antonio Guarna; Andrea Trabocchi; Francesca Bianchini; Ernesto G. Occhiato (2014). Cyclopropane Pipecolic Acids as Templates for Linear and Cyclic Peptidomimetics: Application in the Synthesis of an Arg-Gly-Asp (RGD)-Containing Peptide as an αvβ3 Integrin Ligand. CHEMISTRY-A EUROPEAN JOURNAL, vol. 20, pp. 11187-11203, ISSN:0947-6539 DOI Accesso ONLINE all'editore

Alberto Oppedisano; Cristina Prandi; Paolo Venturello; Annamaria Deagostino; Giulio Goti; Dina Scarpi; Ernesto G. Occhiato (2013). Synthesis of Vinylogous Amides by Gold(I)-Catalyzed Cyclization of N‑Boc-Protected 6‑Alkynyl-3,4-dihydro‑2H‑pyridines. JOURNAL OF ORGANIC CHEMISTRY, vol. 78, pp. 11007-11016, ISSN:0022-3263 DOI Accesso ONLINE all'editore

Dina Scarpi; Laura Bartali; Andrea Casini; Ernesto G. Occhiato (2013). Complementary and Stereodivergent Approaches to the Synthesis of 5-Hydroxy- and 4,5-Dihydroxypipecolic Acids from Enantiopure Hydroxylated Lactams. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2013, pp. 1306-1317, ISSN:1434-193X DOI Accesso ONLINE all'editore

Dina Scarpi; Ottavia Avataneo; Cristina Prandi; Paolo Venturello; Ernesto Occhiato (2012). Synthesis of Both Enantiomers of the Streptomyces Alkaloid 4-epi-SS20846A. SYNTHESIS, vol. 44, pp. 3688-3692, ISSN:0039-7881 DOI Accesso ONLINE all'editore

D. Scarpi; D. Cirelli; C. Matrone; G. Castronovo; P. Rosini; E. G. Occhiato; F. Romano; L. Bartali; A. M. Clemente; G. Bottegoni; A. Cavalli; G. De Chiara; P. Bonini; P. Calissano; A. T. Palamara; E. Garaci; M. G. Torcia; A. Guarna; F. Cozzolino (2012). Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activity. CELL DEATH & DISEASE, vol. 3, pp. 0-0, ISSN:2041-4889 DOI

D. Scarpi; L. Bartali; A. Casini; E. G. Occhiato (2012). Expeditious Racemic and Enantiodivergent Synthesis of1-Deoxymannojirimycin and 1,4-Dideoxymannojirimycin. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. -, pp. 2597-2605, ISSN:1434-193X DOI Accesso ONLINE all'editore

E. G. Occhiato; A. Casini; A. Guarna; D. Scarpi (2011). Diastereodivergent synthesis of 4-hydroxy-2,3-methanopipecolic acid derivatives as conformationally constrained homoserine analogues. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. ---, pp. 6544-6552, ISSN:1434-193X DOI Accesso ONLINE all'editore

C. Prandi; E. G. Occhiato; S. Tabasso; P. Bonfante; M. Novero; D. Scarpi; M. E. Bova; I. Miletto (2011). New Potent Fluorescent Analogues of Strigolactones: Synthesis and Biological Activity in Parasitic Weed Germination and Fungal Branching. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. ---, pp. 3781-3793, ISSN:1434-193X DOI Accesso ONLINE all'editore

D. Scarpi; E. G. Occhiato; A. Guarna; V. Borzatta (2010). One-Pot Pictet-Spengler Reaction and Esterification for the Preparation of a Key Tadalafil Synthetic Intermediate. LETTERS IN ORGANIC CHEMISTRY, vol. 7, pp. 311-313, ISSN:1570-1786

L. Bartali; A. Casini; A. Guarna; E. G. Occhiato; D. Scarpi (2010). Enantiodivergent chemoenzymatic synthesis of 4-hydroxypiperidine alkaloids. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. ---, pp. 5831-5840, ISSN:1434-193X DOI

C. M. Scimia; D. Scarpi, D. Cirelli, F. Romano, J. Francalanci, M. G. Torcia, E. Garaci, A. Guarna, G. Condorelli, F. Cozzolino (2010). Nerve Growth Factor mimetics reduce infarct size and functional damage upon coronary artery ligation in mice. In: Cardiovascular Development and Repair - Keystone Symposia, Keystone - Colorado - USA, 28/2-5/3/2010, Keystone Symposia, pp. 0-0.

E.G.Occhiato; D.Scarpi; C.Prandi (2010). Carbonylative Palladium-Catalyzed Reactions of Lactam-, Lactone-, and Thiolactone-Derived Vinyl Triflates and Phosphates for the Synthesis of N-, O-, and S-Heterocycles. HETEROCYCLES, vol. 80, pp. 697-724, ISSN:0385-5414 DOI Accesso ONLINE all'editore

A.Barge; E.G.Occhiato; C.Prandi; D.Scarpi; S.Tabasso; P.Venturello (2010). A New, practical, and efficient method for protecting alcohols as tert-butyl ethers. SYNLETT, vol. ..., pp. 812-816, ISSN:0936-5214 DOI Accesso ONLINE all'editore

V. Borzatta; D. Scarpi; A. Guarna; E. G. Occhiato (2009). Process for the preparation of 2,3,4,9-tetrahydro-1H-beta-carbolin-3-carboxylic acid esters. Numero: EP2260034 ENDURA S.p.A.Università degli Studi di Firenze

L. Bartali; D. Scarpi; A. Guarna; C. Prandi; E. G. Occhiato (2009). Chemistry of lactam-derived vinyl phosphates: stereoselective synthesis of (+)-fagomine. SYNLETT, vol. .., pp. 913-916, ISSN:0936-5214 DOI

E.G.Occhiato; D.Scarpi; A.Guarna; S.Tabasso; A.Deagostino; C.Prandi (2009). A short and convenient synthesis of enantiopure cis- and trans-4-hydroxypipecolic acid. SYNTHESIS, vol. ..., pp. 3611-3616, ISSN:0039-7881 DOI

D.SCARPI; E.G.OCCHIATO; A.GUARNA (2009). N-Substituent effects on the diethylzinc addition to benzaldehyde catalysed by bicyclic 1,4-aminoalcohols. TETRAHEDRON-ASYMMETRY, vol. 20, pp. 340-350, ISSN:0957-4166 DOI

D. Cirelli; D. Scarpi; P. Bonini; F. Romano; F. Cozzolino; A. Guarna (2009). Discovery of novel ligands of the high affinity NGF receptor Trk-A. In: Biotech.org Chimica organica e Biotecnologie: sfide e opportunità, Forte dei Marmi (LU), 20-23/05/2009, Biotech.org, pp. 0-0.

V.Borzatta; D.Scarpi; E.G.Occhiato; A.Guarna (2008). Procedimento per la preparazione di esteri di acidi tetraidro-1H-betacarbonil-3-carbossilici. Numero: EP2260034 Università degli Studi di Firenze - Endura SPA

E. OCCHIATO; D. SCARPI; A. GUARNA (2008). Stereoselective Synthesis of (2S,4R)-4-Hydroxypipecolic Acid. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. ..., pp. 524-531, ISSN:1434-193X, Wiley-VCH Verlag GmBH:PO Box 101161, D 69451 Weinheim Germany:011 49 6201 606147, EMAIL: service@wiley-vch.de, INTERNET: http://www.wiley-vch.de, Fax: 011 49 6201 606328: DOI

Trabocchi, Andrea; Scarpi, Dina; Guarna, Antonio (2008). Structural Diversity of Bicyclic Amino Acids. AMINO ACIDS, vol. 34, pp. 1-24, ISSN:0939-4451 DOI Accesso ONLINE all'editore

A.Cavalli; A.Pacetti; M.Recanatini; C.Prandi; D. Scarpi; E. Occhiato (2008). Predicting Reactivity and Stereoselectivity in the Nazarov Reaction: A Combined Computational and Experimental Study. CHEMISTRY-A EUROPEAN JOURNAL, vol. 14, pp. 9292-9304, ISSN:0947-6539 DOI

E.G. Occhiato; D. Scarpi (2006). Critical survey covering the year 2005: introduction and transformation of functional groups. In: XXXI Summer School A Corbella, Gargnano, 19-23/06/2006, Società Chimica Italiana, pp. 259-282, ISBN:88-86208-30-8

TRABOCCHI A.; MENCHI G.; GUARNA F.; MACHETTI F.; SCARPI D.; A. GUARNA (2006). Design, Synthesis and Applications of 3-Aza-6,8-Dioxa-Bicyclo[3.2.1]Octane-Based Scaffolds for peptidominetic Chemistry. SYNLETT, vol. ..., pp. 331-353, ISSN:0936-5214, Georg Thieme Verlag Stuttgart:Postfach 301120, D-70451 Stuttgart Germany:011 49 711 8931321, EMAIL: aboservice@thieme.de, INTERNET: http://www.thieme.de, Fax: 011 49 711 8931422: DOI

D.SCARPI; F.LO GALBO; A.GUARNA (2006). Synthesis of a New 1,4-Aminoalcohol and its Use as Catalyst in the Enantioselective Addition of Organozinc to Aldehydes. TETRAHEDRON-ASYMMETRY, vol. 17, pp. 1409-1414, ISSN:0957-4166, PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND, OX5 1GB: DOI

Scarpi, Dina; Stranges, D.; Trabocchi, Andrea; Guarna, Antonio (2006). 3-Aza-8,10-dioxa-bicyclo[5.2.1]decane (9-exo BTKa) Carboxylic Acid as New Reverse Turn Inducer: Synthesis and Conformational Analysis of a Model Peptide. TETRAHEDRON, vol. 62, pp. 1575-1582, ISSN:0040-4020, Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010: DOI Accesso ONLINE all'editore

D. SCARPI; E. OCCHIATO; A. GUARNA (2005). SELECTIVITY OF DAUCUS CAROTA ROOTS AND BAKER'S YEAST IN THE ENANTIOSELECTIVE REDUCTION OF GAMMA-NITROKETONES. TETRAHEDRON-ASYMMETRY, vol. 16, pp. 1479-1483, ISSN:0957-4166 DOI

FABIANA ROSATI; IRENE BARDAZZI; PAOLA DE BLASI; LISA SIMI; DINA SCARPI; ANTONIO GUARNA; MARIO SERIO; M. RACCHI; GIOVANNA DANZA (2005). 5alpha-Reductase Activity in Lycopersicon Esculentum: Cloning and Functional Characterization of Ledet2 and Evidences of the Presence of Two Isoenzymes. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 96, pp. 287-299, ISSN:0960-0760 DOI

SCARPI D.; LO GALBO F.; E. OCCHIATO; GUARNA A. (2004). Enantioselective Addition of Diethylzinc to Aldehydes using 1,4-Aminoalcohols as Chiral Ligands.. TETRAHEDRON-ASYMMETRY, vol. 15, pp. 1319-1324, ISSN:0957-4166 DOI

D.SCARPI; J.D.MCBRIDE; R.J.LEATHERBARROW (2004). Inhibition of human beta-tryptase by Bowman-Birk Inhibitor derived peptides: creation of a new tri-functional inhibitor. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 12, pp. 6045-6052, ISSN:0968-0896 DOI

D. SCARPI; D. STRANGES; L. CECCHI; A. GUARNA (2004). Synthesis of New Molecular Scaffolds: 3-Aza-7,9-Dioxa-Bicyclo[4.2.1]Nonane (8-exo BTKa) and 3-Aza-8,10-Dioxa-Bicyclo[5.2.1]Decane (9-exo BTKa) Carboxylic Acids. TETRAHEDRON, vol. 60, pp. 2583-2591, ISSN:0040-4020, Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010: DOI

D.SCARPI; J.D.MCBRIDE; R. J.LEATHERBARROW (2002). Inhibition of Human beta-Tryptase by Bowman-Birk Inhibitor Derived Peptides. JOURNAL OF PEPTIDE RESEARCH, vol. 59, pp. 90-93, ISSN:1397-002X

A.GUARNA; I.BUCELLI; F.MACHETTI; G. MENCHI; E.G.OCCHIATO; D.SCARPI; A.TRABOCCHI (2002). Synthesis of New Enantiopure Bicycles gamma/delta-Amino Acid (BTKa), Derived from Tartaric Acid and alfa-Aminoacetophenone. TETRAHEDRON, vol. 58, pp. 9865-9870, ISSN:0040-4020 DOI

D. SCARPI; E. OCCHIATO; G. DANZA; M. SERIO; A. GUARNA (2002). Synthesis of 17b-N-Substituted 19-Nor-10-Azasteroids as Inhibitors of Human 5a-Reductase I and II. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 10, pp. 3455-3461, ISSN:0968-0896 DOI

A. GUARNA; E.G. OCCHIATO; F. MACHETTI; A. TRABOCCHI; D. SCARPI; G. DANZA; R. MANCINA; A. COMERCI; M. SERIO (2001). Effect of C-Ring Modifications in Benzo[c]quinolizin-3-ones, New Selective Inhibitors of Human 5a-Reductase 1. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 9, pp. 1385-1393, ISSN:0968-0896 DOI

SCARPI D.; OCCHIATO E.G.; TRABOCCHI A.; LEATHERBARROW R.J.; BRAUER A.B.E.; NIEVO M.; A. GUARNA (2001). Introduction of the New Dipeptide Isostere 7-Endo-BtA as Reverse Turn Inducer in a Bowman-Birk Proteinase Inhibitor: Synthesis and Conformational Analysis. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 9, pp. 1625-1632, ISSN:0968-0896 DOI

A. GUARNA; F. MACHETTI; E. OCCHIATO; D. SCARPI; A. COMERCI; G. DANZA; R. MANCINA; M. SERIO; K. HARDY (2000). Benzo[c]quinolizin-3-ones: a novel class of potent and selective nonsteroidal inhibitors of human steroid 5alpha-reductase 1. JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, pp. 3718-3735, ISSN:0022-2623

A. GUARNA; F. MACHETTI; E. OCCHIATO; D. SCARPI; E. LOMBARDI (2000). MODIFICATION OF THE AZA-ROBINSON ANNULATION FOR THE SYNTHESIS OF 4-METHYL-BENZO[C]QUINOLIZIN-3-ONES, POTENT INHIBITORS OF STEROID 5A-REDUCTASE 1. JOURNAL OF ORGANIC CHEMISTRY, vol. 65, pp. 8093-8095, ISSN:0022-3263

A. Guarna; E. G. Occhiato; D. Scarpi; C. Zorn; G. Danza; A. Comerci; R. Mancina; M. Serio (2000). Synthesis of 8-Chloro-benzo[c]quinolizin-3-ones as Potent andSelective Inhibitors of Human Steroid 5-alpha-Reductase 1. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 10, pp. 353-356, ISSN:1464-3405

A. GUARNA; E. OCCHIATO; D. SCARPI; M. PIZZETTI; S. SISI (2000). Stereoselective Meisenheimer Rearrangement using BTAa's as Chiral Auxiliaries. TETRAHEDRON-ASYMMETRY, vol. 11, pp. 4227-4238, ISSN:0957-4166

GUARNA A; E. OCCHIATO; SCARPI D; MENCHI G; MACHETTI F (2000). 3-Aza-6,8-dioxabicyclo (3,2,1) octanes and analogues and combinatorial libraries. Numero: PCT WO 01/64686 A1 Università di Firenze

D. SCARPI; E. OCCHIATO; A. GUARNA (1999). A SHORT AND EFFICIENT ROUTE TO ENANTIOPURE 3,5-DIARYLPYRROLIZIDINES. JOURNAL OF ORGANIC CHEMISTRY, vol. 64, pp. 1727-1732, ISSN:0022-3263

A. GUARNA; A. GUIDI; F. MACHETTI; G. MENCHI; E. OCCHIATO; D. SCARPI; S. SISI; A. TRABOCCHI (1999). Synthesis and reactivity of bicycles derived from tartaric acids and alfa-amino acids: a novel class of conformationally constrained dipeptide isosteres based upon enantiopure 3-aza-6,8-dioxabicyclo[3.2.1]octane-7-carboxylic acid. JOURNAL OF ORGANIC CHEMISTRY, vol. 64, pp. 7347-7364, ISSN:0022-3263

A. GUARNA; E. G. OCCHIATO; D. SCARPI; R. TSAI; G. DANZA; A. COMERCI; R. MANCINA; M. SERIO (1998). Synthesis of benzo[c]quinolizin-3-ones: selective non steroidal inhibitors of steroid 5a-Reductase 1. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 8, pp. 2871-2876, ISSN:0960-894X

E. OCCHIATO; D. SCARPI; F. MACHETTI; A. GUARNA (1998). STEREOSELECTIVITY IN THE TICL4-CATALYSED REEACTION OF DANISHEFSKY'S DIENE WITH A N-(ACYLOXY)IMINIUM ION: SYNTHESIS OF 5A VERSUS 5B D1(2)-19-NOR-10-AZASTEROIDS. PART 4. TETRAHEDRON, vol. 54, pp. 11589-11596, ISSN:0040-4020

A. GUARNA; E. OCCHIATO; F. MACHETTI; D. SCARPI (1998). A CONCISE ROUTE TO 19-NOR-10-AZASTEROIDS, A NEW CLASS OF STEROID 5-REDUCTASE INHIBITORS. 3.1 SYNTHESIS OF (+)-19-NOR-10-AZATESTOSTERONE AND (+)-17B-ACETYLOXY-(5B)-10-AZAESTR-1-EN-3-ONE. JOURNAL OF ORGANIC CHEMISTRY, vol. 63, pp. 4111-4115, ISSN:0022-3263

E. OCCHIATO; D. SCARPI; G. MENCHI; A. GUARNA (1996). SYNTHESIS OF ENANTIOPURE 2,7-DIARYL-1,6-DIOXASPIRO[4.4]NONANES VIA ENANTIOSELECTIVE REDUCTION OF PROCHIRAL G-NITROKETONES BY DIISOPINOCAMPHEYLCHLOROBORANE (DIP-CLTM). TETRAHEDRON-ASYMMETRY, vol. 7, pp. 1929-1942, ISSN:0957-4166

D. SCARPI; G. MENCHI; E. OCCHIATO; A. GUARNA (1996). ASYMMETRIC HYDROGENATION OF PROCHIRAL G-NITROKETONES BY RUTHENIUM COMPLEXES. JOURNAL OF MOLECULAR CATALYSIS. A: CHEMICAL, vol. 110, pp. 129-134, ISSN:1381-1169

A. GUARNA; E. OCCHIATO; D. SCARPI; L. SPINETTI; M. VALLECCHI (1995). BAKER'S YEAST REDUCTION OF PROCHIRAL G-NITROKETONES: ENANTIOSELECTIVE SYNTHESIS OF (S)-4-NITROALCOHOLS. TETRAHEDRON, vol. 51, pp. 1775-1788, ISSN:0040-4020

E. OCCHIATO; A. GUARNA; F. DE SARLO; D. SCARPI (1995). Baker's yeast reduction of prochiral g-nitro ketones. II. Straightforward enantioselective synthesis of 2,7-dimethyl-1,6-dioxaspiro[4.4]nonanes. TETRAHEDRON-ASYMMETRY, vol. 6, pp. 2971-2976, ISSN:0957-4166 DOI

Dina SCARPI

Biography

1995 Degree in Chemistry, University of Florence.

1999 PhD in Chemical Sciences, University of Florence.

2000-2001 Research Associate at the Department of Chemistry of the Imperial College of Science Technology and Medicine, London, UK.

2001-2002 Research Fellow, University of Florence.

2002-2005 Term contracts at the Department of Organic Chemistry and at the Mathematics, Physics and Natural Sciences Faculty of the University of Florence.

2005-2009 Fixed-term Researcher.

2009-at present Tenured Researcher, University of Florence.

Dina SCARPI

Curriculum

Dina Scarpi, PhD. 1995 Degree in Chemistry (full marks), University of Florence. 2000 PhD in Chemical Sciences (XII Course), University of Florence. 2000-2001 Research Associate at the Department of Chemistry of the Imperial College of Science Technology and Medicine, London, UK. 2001-2002 Research Fellow. 2002-2005 Term contracts at the Department of Organic Chemistry and at the Mathematics, Physics and Natural Sciences Faculty of the University of Florence. 2005-2009 Fixed-term Researcher. 2009-currently University of Florence, Tenured Researcher.

Dina SCARPI

Interest

Organic synthesis, by means of standard techniques as well as biotransformations, and its application to medicinal chemistry; study of the structure-activity relationship of enzyme inhibitors and receptor ligands; natural products synthesis; new chiral ligands development for enantioselective metal-catalysed reactions.