Personale

Recapiti

Orario di ricevimento

Italiano

Biografia

Curriculum

Interessi

Pubblicazioni

Insegnamenti

English

Biography

Curriculum

Interest

Marzia CIRRI

Ruolo attuale:: Professore Associato
SSD:: CHEM-08/A - Tecnologia, socioeconomia e normativa dei medicinali e dei prodotti per il benessere e per la salute
Afferenza organizzativa:: Dipartimento di Chimica 'Ugo Schiff' - DICUS

Recapiti

	0554573674
	marzia.cirri(AT)unifi.it

Marzia CIRRI

Biografia

Professore associato presso il Dipartimento di Chimica (DICUS), Univ. di Firenze.

Titolare del corso 'Produzione e normativa dei medicinali' e Impianti dell'industria farmaceutica, docente 'Lab. Tecnologia, socioeconomia e legislazione farmaceutiche', docente di 'Preformulazione esistemi a rilascio modificato' e 'Chimica Farmaceutica Applicata', CdL CTF, SSSU.

Abilitazione accademica nazionale per professore ordinario. Autore di 86 pubblicazioni (84 research papers e 2 review) (SCOPUS h index=41; >3700 citazioni) su riviste internazionali e nazionali nel campo della tecnologia farmaceutica e >100 comunicazioni (orali e poster) a congressi nazionali e internazionali. Autore di un capitolo di libro e di un contributo traduzione di un capitolo di libro. Referee per numerose riviste scientifiche internazionali e membro del comitato editoriale di riviste scientifiche.

Correlatore di tesi di dottorato, relatore e correlatore di tesi di laurea sperimentale. Attività di docenza Erasmus: Univ. Granada, Madrid e Zagabria. Ha Partecipato a organizzazione di simposi e workshop. Affiliata a varie società scientifiche e associazioni. Ha ricoperto incarichi di Revisore PRIN e revisore VQR 2015-19.

Incarichi accademici UniFi: Membro di: Commissione di Esami CHIM/09, Commissioni Giudicatrici di Laurea in C.T.F., Commissione Giudicatrice per gli Esami di Stato di Abilitazione all’esercizio della Professione di Farmacista, Commissione per Assegni di ricerca e borse di ricerca, Commissione concorso per RTDA, CPDS della SSSU, Commissione Strumentazione Dipartimentale, Commissione giudicatrice della Prova Pratica Valutativa (PPV) triennio 2024-2026, Commissione d’aula test CISIA

Linee di ricerca: sviluppo e la caratterizzazione di formulazioni innovative volte a migliorare la biodisponibilità del farmaco, mediante complessazione del farmaco con ciclodestrine, dispersioni solide e sistemi attivati meccanicamente con carrier polimerici e/o con ciclodestrine; vettorizzazione del farmaco in diverse tipologie di carrier colloidali (nanoparticelle lipidiche solide (SLN), carrier lipidici nanostrutturati (NLC), micelle, liposomi, niosomi, nanoparticelle polimeriche, ecc.) sfruttando anche strategie combinate con l'uso di ciclodestrine (sistemi misti "farmaco-in-ciclodestrina-in-nanocarrier lipidici") per uso orale e topico; sviluppo di sistemi di somministrazione buccale, nasale o vaginale bioadesivi e/o termosensibili per azione locale o sistemica; sviluppo e caratterizzazione di formulazioni pediatriche innovative.

Marzia CIRRI

Curriculum

Posizione attuale

Dal 2019: Prof. Associato CHEM-08/A - Tecnologia, socioeconomia e normativa dei medicinali e dei prodotti per il benessere e per la salute, Dipartimento di Chimica (DICUS) Scuola Scienze Salute Umana, Università degli Studi di Firenze, titolare del corso di "Impianti dell'Industria Farmaceutica"; docente del corso di Tecnologia, Socioeconomia e legislazione farmaceutiche (per 2 CFU lab + 1 CFU es. aula) per il CdL in CTF, Scuola SSU, Univ. Firenze; docente del corso 'Chimica farmaceutica applicata' (per 1 CFU lez + 1 CFU es. in aula) per il CdL in CTF, Scuola SSU, Univ. Firenze

Formazione e titoli

2018: Abilitazione Scientifica Nazionale per Prof. I Fascia, SC 03/D2, SSD CHIM/09-Tecnologia, Socioeconomia e Normativa dei Medicinali- all'unanimità. Bando D.D. n.1532/2016; validità 31/10/2018-31/10/2030

2001-2004: Dottorato di Ricerca in “Chimica e Tecnologia del Farmaco” presso l’Università di Firenze; Titolo: “Preparazione e caratterizzazione di formulazioni innovative mirate a migliorare la biodisponibilità di farmaci”

2002: nomina di Cultore della materia nel settore Farmaceutico Tecnologico Applicativo CHIM/09

2000: Abilitazione all’esercizio della professione di Farmacista (Università di Firenze)

2000: Laurea in Chimica e Tecnologia Farmaceutiche presso l’Università di Firenze

Attività professionali

2016-2019: Ricercatore a Tempo Determinato tip. b) SSD Farmaceutico Tecnologico Applicativo (CHIM/09), Dip. Chimica, Scuola di SSU, Univ. Firenze

2015-2016: Ricercatore a Tempo Determinato tip. a) SSD Farmaceutico Tecnologico Applicativo (CHIM/09), Dip. Chimica, Scuola di SSU, Univ. Firenze

2011-2013: Attività di ricerca e consulenza nel campo della Tecnologia Farmaceutica

2010: Borsista nel settore scientifico disciplinare Farmaceutico Tecnologico Applicativo (CHIM/09), presso Facoltà di Farmacia, Università di Firenze; Titolo: “Formulazioni innovative per il miglioramento delle caratteristiche chimico-fisiche di principi attivi”

2004-2010: Assegnista di Ricerca nel settore scientifico disciplinare Farmaceutico Tecnologico Applicativo (CHIM/09), presso Facoltà di Farmacia, Università di Firenze; Titolo: “Miglioramento delle caratteristiche biofarmaceutiche di farmaci e studi di preformulazione”

Attività didattica

Da a.a. 2022/2023 ad oggi: Titolare del corso di insegnamento 'Impianti dell’Industria Farmaceutica' (9 CFU); docente del corso di insegnamento ‘Chimica Farmaceutica Applicata’ del Corso di Laurea Magistrale a ciclo unico in C.T.F., SSSU, Univ. Firenze

Da a.a. 2020/2021 ad oggi: docente del corso di insegnamento 'Tecnologia, Socio-economia e Legislazione Farmaceutiche', del Corso di Laurea Magistrale a ciclo unico in C.T.F., SSSU, Univ. Firenze

a.a. 2015/2016 - 2021/2022: Titolare del corso di insegnamento “Impianti dell’Industria Farmaceutica” (7.5 CFU) settore CHIM/09 (Farmaceutico Tecnologico Applicativo) del Corso di Laurea Magistrale a ciclo unico in C.T.F. e “Tecnica e Impianti della Produzione Farmaceutica” del Corso di Laurea in Scienze Farmaceutiche Applicate-Controllo Qualità (fino all'a.a 2019/2020) con esso mutuato. SSSU, Univ.Firenze

2018: Incarico di docenza presso 6^th NanoFar School: European Doctorate in nanomedicine and pharmaceutical innovation, iniziativa Erasmus Mundus Programme, Univ. Modena and Reggio-Emilia, 11^th-15^th June 2018. “Nanostructured lipid systems as safe and effective delivery systems for oral drug administration in paediatric therapy”

2010-2014: Docenza a contratto per i corsi di “Tecnologia, Socio-economia e Legislazione Farmaceutiche” e/o “Impianti dell’Industria Farmaceutica” per il CdL in CTF e corsi a comune; Univ. Firenze

2001-2009 Assistenza didattica: modulo di lezioni “Illustrazione delle tecniche preparative delle principali forme farmaceutiche convenzionali ai fini della spedizione delle ricette, nel Corso di Tecnologia, Socio-economia e Legislazione Farmaceutiche, CdL in CTF, Univ. Firenze

2001-2012: Assistenza didattica per esercitazioni pratiche di Laboratorio del Corso di Tecnologia, Socio-economia e Legislazione Farmaceutiche, CdL in CTF, Univ. Firenze

2002: tenuto un ciclo di lezioni “Sistemi a matrice per il rilascio modificato di farmaci. Applicazione dei sistemi a matrice nelle forme farmaceutiche” nell’ambito del Corso di Aggiornamento ECM, presso Ordine Farmacisti della Provincia di Arezzo

Attività didattica all'estero

a.a 2015/2016: Teaching Staff nell'ambito del programma Erasmus+ presso Dept. Pharmaceutical Technology, Faculty of Pharmacy and Biochemistry, Univ. of Zagreb

a.a. 2016/2017 Teaching Staff nell'ambito del programma Erasmus+, Departamento de Farmacia y Tecnologia Farmaceutica, Facultad de Farmacia, Universidad Complutense de Madrid

a.a. 2017/2018 Teaching staff nell’ambito del programma Erasmus+ presso Dept. Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Spagna, su invito del Prof. César Viseras Iborra

Attività Istituzionali

• Correlatore di Dottorato di Ricerca Ciclo XL in ‘Area del Farmaco e Trattamenti Innovativi’, UNIFI

• Tutor teorico di Dottorato di Ricerca Ciclo XXXV (2019-2022) in ‘Area del Farmaco e Trattamenti Innovativi’, UNIFI

• Presidente della Commissione di Esami di ’Produzione e normativa dei medicinali’ e ‘Impianti dell’industria farmaceutica’ nell’ambito del Corso di Laurea in C.T.F., SSSU, Univ. Firenze

• membro della Commissione di Esami ‘Chimica Farmaceutica Applicata’, del Corso di Laurea in C.T.F., Univ. Firenze

• membro della Commissione Giudicatrice di Laurea in C.T.F., dal 2003;

• membro della Commissione Giudicatrice per gli Esami di Stato di Abilitazione all’esercizio della Professione di Farmacista

• membro di Commissione per Assegni di ricerca e borse di ricerca (dal 2018)

• membro di Commissione concorso per RTDA (PNNR, PNC e PNR) (2022)

• membro della CPDS (Commissione Paritetica Docenti- Studenti) della SSSU dal 2022

• membro della Commissione ‘Progetti di Eccellenza’ (2023)

• membro della Commissione Strumentazione Dipartimentale (dal 2024)

• membro della Commissione giudicatrice della Prova Pratica Valutativa (PPV) triennio 2024-2026

• membro di commissione d’aula test CISIA

Altre attività

• incarico di Revisore PRIN

• incarico di Revisore esterno VQR 2015-2019 (2021)

• relatore di tesi sperimentali di Laurea in C.T.F., dal 2016 ad oggi; in SFA/CQ nel 2020;

• correlatore di tesi sperimentali di Laurea in C.T.F., dal 2003 ad oggi;

• supervisore di tesi (master) internazionali (dal 2017)

• tutor di studenti Erasmus in stage per progetti di ricerca (dal 2017)

• attività di assistenza agli studenti per la preparazione di tesi di laurea dal 2001

Attività organizzative e di supporto

2023: Session Co-Chair at Online Conference On Advanced Nano Drug Delivery Systems (NanoD2S - 2023) November 27-28, 2023 | Online - Zoom

2014: membro del comitato organizzatore del 7^th Annual Thematic Workshop of CRS Italy Chapter: “Nanomedicine: pharmacokinetic challenges, targeting and clinical outcomes”. 6-8 Novembre 2014, Firenze

2012: membro del comitato organizzatore XII Scuola Nazionale Dottorale per la formazione avanzata in Discipline Tecnologico Farmaceutiche "I medicinali biotecnologici" 10-12 Settembre 2012, Univ. degli Studi di Firenze

Affiliazione a società/associazioni scientifiche:

SITELF (Società Italiana di Tecnologia e Legislazione Farmaceutiche); SCI (Società Chimica Italiana) - Divisione Tecnologia Farmaceutica; CRS sez. Italiana (Controlled Release Society); AFI (Associazione Farmaceutici Industria); A.It.U.N-AAPS Italian University Network; EPTRI (European Paediatric Translational Research Infrastructure); CDTEC (Assoc. Ital. Chim. e Tecnol. delle Ciclodestrine); PDA Italy Chapter

Partecipazione a progetti di ricerca ammessi al finanziamento:

• PRIN 2022: ‘Smart injectable Hydrogels carrying multi-functional nano-systEms to tackle chRonic wound biOfilm through an antibiotic-free approach (HERO)’ (durata 24 mesi (2023-2025); ruolo: partecipante)

• Finanziamento di progetti competitivi per Ricercatori a Tempo Determinato (RTD) (Bando 2020-2021) dell’Università di Firenze. Titolo del progetto finanziato: “Development and characterization of nanovesicles functionalized with biomimetic carbohydrate receptors for mannose-targeted antitumoral drugs delivery” (durata: 24 mesi; ruolo: Ricercatore partner)

• PRIN 2007: "Strategie chemiometriche nello sviluppo, enantiorisoluzione e determinazione di farmaci" (durata: 24 mesi; ruolo: partecipante)

Altri finanziamenti:

• finanziamento per pubblicazioni – anno 2017

• finanziamento per pubblicazioni – anno 2018

• finanziamento annuale individuale delle attività base di ricerca (FFABR 2018)

Collaborazione scientifica con gruppi di ricerca di altri Atenei ed enti di ricerca nazionali e internazionali:

- Univ. Milano: Dip. Scienze per gli Alimenti, la Nutrizione e l'Ambiente (DeFENS)

- Univ. Pavia: Dipartimento di Chimica Farmaceutica

- Univ. Bologna: Dipartimento di Scienze Farmaceutiche

- Univ. Roma, Sapienza: Dip. Chimica e Tecnologie del farmaco

- Univ. Firenze: Dip. NEUROFARBA, Sez. Farmacologia e Tossicologia

- Univ. Firenze: Dip. NEUROFARBA, Sez. Farmaceutica e Nutraceutica

- Univ. Firenze: Dip. Biologia

- Univ. Siviglia (Spagna): Dep.to de Farmacia y Tecnología Farmacéutica

- Univ. Alcalà (Spagna): Dep. de Farmacia y Tecnología Farmaceutica, Facultad de Farmacia

- Univ. Complutense di Madrid (Spagna): Dep.to Farmacia y Tecnología Farmacéutica, Facultad de Farmacia

- Univ. Granada (Spagna): Dept of Pharmacy and Pharmaceutical Technology

- CSIC-Univ. Granada (Spagna): Andalusian Institute of Earth Sciences

- Univ. Lisbona (Portogallo) Faculdade de Farmácia: Dep.to de Farmácia Galénica e Tecnologia Farmacêutica

- Univ. Lisbona (Portogallo) Faculty of Pharmacy: Research Institute for Medicines and Pharmaceutical Sciences (iMed.ULisboa)

- Isfahan University of Medical Sciences (Iran): Dept of Pharmaceutics

- Isfahan University of Technology (Iran): Dept of Food Science and Technology

- Univ. Paris V (Francia): Laboratoire de Pharmacie Galenique

- Univ. Würzburg (Germania): Dept. Endocrinology

- Univ. Emirati Arabi Uniti (UAE): Department of Chemical & Petroleum Engineering

- Pacific Northwest National Laboratory, Richland, WA, USA

- Univ. Antioquia (Colombia): Facultad de Farmacia

- Univ. Zagabria (Croazia): Dept. Pharmaceutical Technology, Faculty of Pharmacy and Biochemistry

- Univ. Zagabria (Croazia): Dept. Microbiology, Faculty of Pharmacy and Biochemistry

- Univ. Nacional de Cordoba (Argentina): Facultad de Ciencias Químicas, Unidad de Investigacion y Desarrollo en Tecnología Farmaceutica (UNITEFA), CONICET and Departamento de Ciencias Farmaceuticas

- Queen’s University Belfast (Irlanda del Nord): School of Pharmacy, Medical Biology Centre

- Euphar Group s.r.l., Piacenza

- Actimex s.r.l., Basovizza, Trieste

- Menarini Manufacturing Logistic & Services, Firenze

- Pharmaceutical Development and Service, Firenze

- USL Sud Est, UOC Farmaceutica Territoriale, Arezzo

- Azienda USL8 U.O.Farmacia Ospedaliera, Arezzo

- Istituto Zooprofilattico dell’Umbria e delle Marche, Perugia

Partecipazione come relatore a convegni di carattere scientifico in Italia o all'estero

17 presentazioni orali di cui 2 Invited a convegni Nazionali, 1 Invited Plenary e 1 Keynote a convegni Internazionali

Attività di referee

Riviste scientifiche internazionali: Pharmaceutics, European Journal of Pharmaceutics and Biopharmaceutics, European Journal of Pharmaceutical Sciences, International Journal of Pharmaceutics, Drug Delivery, Journal of Drug Delivery Science and Technology, Journal of Pharmaceutical and Biomedical Analysis, Journal of Thermal Analysis and Calorimetry, Drug Development and Industrial Pharmacy, Chemistry and Physics of Lipids, Colloids and Surfaces B: Biointerfaces, Planta Medica, Particulate Science and Technology, Current Pharmaceutical Design, Acta Pharmaceutica, International Journal of Nanomedicine

Attività in Comitati Editoriali:

- membro dell’Editorial Board della rivista: - International Journal of Pharma Research and Health Sciences (IJPRHS), eISSN : 2348-6465

- membro dell’Editorial Board della rivista open-access ‘Pharmaceutics’ - Multidisciplinary Digital Publishing Institute (MDPI) ISSN:1999-4923

- Guest Editor di diversi Special Issues della rivista open-access ‘Pharmaceutics’ - Multidisciplinary Digital Publishing Institute (MDPI) ISSN:1999-4923

- Editor of the Book ‘Cyclodextrins in Drug Delivery’, ristampa di articoli pubblicati nello Special Issue della rivista open-access ‘Pharmaceutics’ (ISSN 1999-4923)

Pubblicazioni e attività scientifica

- autore di 86 pubblicazioni (84 research papers + 2 Review) e >100 comunicazioni a Congressi Internazionali e Nazionali e Workshop

- autore di un capitolo di libro ‘Tecnologia Farmaceutica’, Casa Editrice Ambrosiana, 2025

- contributo all’Edizione Italiana (in qualità di traduttore) del libro: H.C. Ansel and S.J. Stockton ‘Pharmaceutical Calculations - 15^th Edition’ ISBN/ISSN 978-1-4963-3962-1 (Principi di Calcolo Farmaceutico – 15^a Edizione ISBN 978-88-214-4394-7; eISBN 978-88-214-4395-4) Edra Ed.

Indicatori bibliometrici (Fonte: Scopus, Marzo 2025):

pubblicazioni = 85

h index = 41

citazioni = 3670

Premi e riconoscimenti per l'attività scientifica:

- Premio Retsch Scientific Challenge 2024 - Mixer Mill MM200. "Comacinazione: un approccio ‘green and safe’ per il mascheramento del gusto (taste masking) di farmaci nella terapia pediatrica orale"

- Premio CRS Italy Chapter 2017 “Thermosensitive gels for pediatric mucositis: preformulation studies”

- "Top 20 article" (n. 8 nel 2014, n. 1 nel 2015) per la pubblicazione: Cirri M., Bragagni M., Mennini N., Mura P. Development of a new delivery system consisting in "drug - in cyclodextrin - in nanostructured lipid carriers" for ketoprofen topical delivery. Eur. J. Pharm. Biopharm. 2012; 80 (1): 46-53

- Premio Vespucci 2006 (Ricerca, Innovazione Etica in Toscana) per il progetto "Smart-Test";

- Premio "Miglior poster": “Development and evaluation of an artificial membrane for high throughput assessment of drug absorption potential” 43° Simposio AFI 2003. Perugia, 11-13 Giugno 2003

Principali linee di Ricerca:

Sviluppo e caratterizzazione di formulazioni innovative mirate a migliorare la biodisponibilità di farmaci.

Miglioramento delle caratteristiche sfavorevoli di farmaci attraverso complessazione di farmaci con ciclodestrine, realizzazione di dispersioni solide e di sistemi attivati meccanicamente con carrier di natura polimerica e/o con ciclodestrine. Preparazione, caratterizzazione chimico-fisica e valutazione biofarmaceutica di tali sistemi.

Preparazione, caratterizzazione e valutazione biofarmaceutica di forme farmaceutiche innovative solide (sistemi matriciali e sistemi a rilascio colonico), semisolide (gel per uso topico e transdermico), e liquide (microemulsioni, SMEDDS, nanoparticelle lipidiche).

Preparazione, caratterizzazione chimico-fisica e valutazione biofarmaceutica di sistemi misti drug-in-cyclodextrin-in-lipidic nanocarriers per uso orale e topico.

Sviluppo e caratterizzazione di formulazioni pediatriche innovative.

Studi di stabilità; studi di compatibilità farmaco-eccipiente.

Marzia CIRRI

Pubblicazioni

Legenda

Contributo su rivista |

Articolo su libro |

Libro |

Contributo in atti di convegno (proceeding) |

Brevetto |

Curatela | Altro

Altro |

Tesi di Dottorato

Francesca Maestrelli; Marzia Cirri (2025). Tecnologia Farmaceutica. In: Paolo Caliceti. Tecnologia Farmaceutica, pp. 1-654, Bologna: Zanichelli, ISBN:978-88-08-49975-2. Accesso ONLINE all'editore

Maestrelli, Francesca; Cirri, Marzia; Mennini, Natascia; Fiani, Silvia; Stoppacciaro, Beatrice; Mura, Paola (2024). Development of Oral Tablets of Nebivolol with Improved Dissolution Properties, Based on Its Combinations with Cyclodextrins. PHARMACEUTICS, vol. 16, pp. 0-0, ISSN:1999-4923 DOI

Paola A. Mura, Marzia Cirri, Santiago D. Palma, Alan Rossetti, Daniel A. Allemandi, Alejandro J. Parede (2024). Preparation of glyburide nanocrystals with improved dissolution properties by dry-ball- and wet-bead- milling: Systematic comparison by experimental design of the performance of the two methods.. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, vol. 91, pp. 1-12, ISSN:1773-2247 DOI

Mura, P.; Maestrelli, F.; Gonçalves, L.M.D.; Cirri, M.; Mennini, N.; Almeida, A.J. (2024). Cyclodextrin complexation as a fruitful strategy for improving the performance of nebivolol delivery from solid lipid nanoparticles. INTERNATIONAL JOURNAL OF PHARMACEUTICS, pp. 0-0, ISSN:0378-5173 DOI

Marzia Cirri, Paola A. Mura, Francesca Maestrelli, Simona Benedetti, Susanna Buratti (2024). Pediatric Orally Disintegrating Tablets (ODTs) with Enhanced Palatability Based on Propranolol HCl Coground with Hydroxypropyl-β-Cyclodextrin. PHARMACEUTICS, vol. 16, pp. 1351-1364, ISSN:1999-4923 DOI

Burrini, Nastassja; D'Ambrosio, Mario; Gentili, Matteo; Giaquinto, Roberta; Settimelli, Veronica; Luceri, Cristina; Cirri, Marzia; Francesconi, Oscar (2023). Niosomes Functionalized with a Synthetic Carbohydrate Binding Agent for Mannose-Targeted Doxorubicin Delivery. PHARMACEUTICS, vol. 15, pp. 1-19, ISSN:1999-4923 DOI

Marzia Cirri, Paola Mura, Simona Benedetti, Susanna Buratti (2023). Development of a Hydroxypropyl-beta -Cyclodextrin-based liquid formulation for the oral administration of propranolol in pediatric therapy. PHARMACEUTICS, vol. 15, pp. 2217-2232, ISSN:1999-4923 DOI

Nerli, Giulia; Gonçalves, Lídia M D; Cirri, Marzia; Almeida, António J; Maestrelli, Francesca; Mennini, Natascia; Mura, Paola A (2023). Design, Evaluation and Comparison of Nanostructured Lipid Carriers and Chitosan Nanoparticles as Carriers of Poorly Soluble Drugs to Develop Oral Liquid Formulations Suitable for Pediatric Use. PHARMACEUTICS, vol. 15, pp. 0-0, ISSN:1999-4923 DOI Accesso ONLINE all'editore

Maestrelli, Francesca; Cirri, Marzia; De Luca, Enrico; Biagi, Diletta; Mura, Paola (2022). Role of Cyclodextrins and Drug Solid State Properties on Flufenamic Acid Dissolution Performance from Tablets. PHARMACEUTICS, vol. 14, pp. 0-0, ISSN:1999-4923 DOI

Paola Mura, Francesca Maestrelli, Marzia Cirri, Natascia Mennini (2022). Multiple Roles of Chitosan in Mucosal Drug Delivery: An Updated Review. MARINE DRUGS, vol. 20, pp. 0-0, ISSN:1660-3397 DOI

Cirri, Marzia; Nerli, Giulia; Mennini, Natascia; Maestrelli, Francesca; Mura, Paola (2022). Development and Characterization of Cyclodextrin-Based Nanogels as a New Ibuprofen Cutaneous Delivery System. PHARMACEUTICS, vol. 14, pp. 2567-2581, ISSN:1999-4923 DOI Accesso ONLINE all'editore

Angeli A.; Berrino E.; Carradori S.; Supuran C.T.; Cirri M.; Carta F.; Costantino G. (2021). Amine-and amino acid-based compounds as carbonic anhydrase activators. MOLECULES, vol. 26, pp. 0-0, ISSN:1420-3049 DOI

Cirri M.; Mennini N.; Nerli G.; Rubia J.; Casalone E.; Melani F.; Maestrelli F.; Mura P. (2021). Combined use of cyclodextrins and amino acids for the development of cefixime oral solutions for pediatric use. PHARMACEUTICS, vol. 13, pp. 0-0, ISSN:1999-4923 DOI

Mura P.; Maestrelli F.; Cirri M.; Nerli G.; Di Cesare Mannelli L.; Ghelardini C.; Mennini N. (2021). Improvement of butamben anesthetic efficacy by the development of deformable liposomes bearing the drug as cyclodextrin complex. PHARMACEUTICS, vol. 13, pp. 0-0, ISSN:1999-4923 DOI

Mura, Paola; Maestrelli, Francesca; D'Ambrosio, Mario; Luceri, Cristina; Cirri, Marzia (2021). Evaluation and Comparison of Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs) as Vectors to Develop Hydrochlorothiazide Effective and Safe Pediatric Oral Liquid Formulations. PHARMACEUTICS, vol. 13, pp. 0-0, ISSN:1999-4923 DOI

Cirri M.; Maestrelli F.; Scuota S.; Bazzucchi V.; Mura P. (2021). Development and microbiological evaluation of chitosan and chitosan-alginate microspheres for vaginal administration of metronidazole. INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 598, pp. 0-0, ISSN:0378-5173 DOI

Cirri M.; Maestrelli F.; Nerli G.; Mennini N.; D'ambrosio M.; Luceri C.; Mura P.A. (2021). Development of a cyclodextrin-based mucoadhesive-thermo-sensitive in situ gel for clonazepam intranasal delivery. PHARMACEUTICS, vol. 13, pp. 0-0, ISSN:1999-4923 DOI

Francesca Maestrelli, Marzia Cirri, Fátima García-Villén, Ana Borrego-Sánchez , César Viseras Iborra, Paola Mura (2020). Tablets of “Hydrochlorothiazide in Cyclodextrin in Nanoclay”: A New Nanohybrid System with Enhanced Dissolution Properties. PHARMACEUTICS, vol. 12, pp. 1-15, ISSN:1999-4923 DOI Accesso ONLINE all'editore

Cirri, Marzia; Maestrelli, Francesca; Mennini, Natascia; Di Cesare Mannelli, Lorenzo; Micheli, Laura; Ghelardini, Carla; Mura, Paola (2020). Development of a stable oral pediatric solution of hydrochlorothiazide by the combined use of cyclodextrins and hydrophilic polymers. INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 587, pp. 119692-119692, ISSN:0378-5173 DOI Accesso ONLINE all'editore

Soleimanian, Yasamin; Goli, Sayed Amir Hossein; Varshosaz, Jaleh; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Cirri, Marzia; Maestrelli, Francesca (2020). β-Sitosterol Loaded Nanostructured Lipid Carrier: Physical and Oxidative Stability, In Vitro Simulated Digestion and Hypocholesterolemic Activity. PHARMACEUTICS, vol. 12, pp. 0-0, ISSN:1999-4923 DOI Accesso ONLINE all'editore

Marzia Cirri, Paola Mura, Maurizio Valleri, Letizia Brunetti (2020). Development and characterization of liquisolid tablets based on mesoporous clays or silicas for improving glyburide dissolution. PHARMACEUTICS, vol. 12, pp. 0-0, ISSN:1999-4923 DOI Accesso ONLINE all'editore

Mura, P., Valleri, M., Fabianelli, E., Maestrelli, F., Cirri, M. (2019). Characterization and evaluation of different mesoporous silica kinds as carriers for the development of effective oral dosage forms of glibenclamide,. INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 563, pp. 53-62, ISSN:0378-5173 DOI Accesso ONLINE all'editore

F. Maestrelli, M. Jug, M. Cirri, I. Kosalec, P. Mura (2018). Characterization and microbiological evaluation of chitosan-alginate microspheres for cefixime vaginal administration. CARBOHYDRATE POLYMERS, vol. 192, pp. 176-183, ISSN:0144-8617 DOI Accesso ONLINE all'editore

Marzia Cirri , Lavinia Maestrini , Francesca Maestrelli , Natascia Mennini , Paola Mura , Carla Ghelardini, Lorenzo Di Cesare Mannelli (2018). Design, characterization and in vivo evaluation of nanostructured lipid carriers (NLC) as a new drug delivery system for hydrochlorothiazide oral administration in pediatric therapy. DRUG DELIVERY, vol. 25, pp. 1910-1921, ISSN:1521-0464 DOI Accesso ONLINE all'editore

Marzia Cirri, Francesca Maestrelli , Paola Mura, Carla Ghelardini, Lorenzo Di Cesare Mannelli (2018). Combined Approach of Cyclodextrin Complexation and Nanostructured Lipid Carriers for the Development of a Pediatric Liquid Oral Dosage Form of Hydrochlorothiazide. PHARMACEUTICS, vol. 10, pp. 0-0, ISSN:1999-4923 DOI

Bragagni M, Gil-Alegre ME, Mura P, Cirri M, Ghelardini C, Di Cesare Mannelli L (2018). Improving the therapeutic efficacy of prilocaine by PLGA microparticles: Preparation, characterization and in vivo evaluation.. INTERNATIONAL JOURNAL OF PHARMACEUTICS, pp. 24-30, ISSN:0378-5173 DOI

P. Mura, S. Orlandini, M. Cirri, F. Maestrelli*, N. Mennini, G. Casella, S. Furlanetto (2018). A preliminary study for the development and optimization by experimental design of an in vitro method for prediction of drug buccal absorption. INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 547, pp. 530-536, ISSN:0378-5173 DOI

maestrelli Francesca; cirri marzia (2017). Principi di calcolo farmaceutico. In: Gaia Colombo, Alessandra Rossi, Paola Russo, Fabio Sonvico. Principi di calcolo farmaceutico, pp. 1-450, Milano: Edra, ISBN:978-88-214-4394-7.

Maestrelli, Francesca; Mura, Paola; Cirri, Marzia; Mennini, Natascia; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo (2017). Development and characterization of fast dissolving tablets of oxaprozin based on hybrid systems of the drug with cyclodextrins and nanoclays. INTERNATIONAL JOURNAL OF PHARMACEUTICS, pp. 0-0, ISSN:0378-5173 DOI Accesso ONLINE all'editore

Cirri, Marzia; Mennini, Natascia; Maestrelli, Francesca; Mura, Paola; Ghelardini, Carla; di Cesare Mannelli, Lorenzo (2017). Development and in vivo evaluation of an innovative “Hydrochlorothiazide-in Cyclodextrins-in Solid Lipid Nanoparticles” formulation with sustained release and enhanced oral bioavailability for potential hypertension treatment in pediatrics. INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 521, pp. 73-83, ISSN:0378-5173 DOI Accesso ONLINE all'editore

Maestrelli Francesca; Cirri Marzia (2017). Esercizi di ripasso. In: Gaia Colombo, Alessandra Rossi, Paola Russo, Fabio Sonvico. Principi di calcolo farmaceutico, pp. 417-440 Edra, ISBN:9788821443947.

Mennini, Natascia; Maestrelli, Francesca; Cirri, Marzia; Mura, Paola (2016). Analysis of physicochemical properties of ternary systems of oxaprozin with randomly methylated-ß-cyclodextrin and L-arginine aimed to improve the drug solubility. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 129, pp. 350-358, ISSN:0731-7085 DOI Accesso ONLINE all'editore

Mennini, N.; Cirri, M.; Maestrelli, F.; Mura, P (2016). Comparison of liposomal and NLC (nanostructured lipid carrier) formulations for improving the transdermal delivery of oxaprozin: Effect of cyclodextrin complexation. INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 515, pp. 684-691, ISSN:0378-5173 DOI Accesso ONLINE all'editore

Mura, P.; Cirri, M.; Mennini, N.; Casella, G.; Maestrelli, F (2016). Polymeric mucoadhesive tablets for topical or systemic buccal delivery of clonazepam: Effect of cyclodextrin complexation. CARBOHYDRATE POLYMERS, vol. 152, pp. 755-763, ISSN:0144-8617 DOI Accesso ONLINE all'editore

Mennini, Natascia; Casella, Giada; Cirri, Marzia; Maestrelli, Francesca; Mura, Paola (2016). Development of cyclodextrin hydrogels for vaginal delivery of dehydroepiandrosterone. JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 68, pp. 762-771, ISSN:0022-3573 DOI Accesso ONLINE all'editore

Cirri, Marzia; Roghi, Alessandra; Valleri, Maurizio; Mura, Paola (2016). Development and characterization of fast-dissolving tablet formulations of glyburide based on solid self-microemulsifying systems. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 104, pp. 19-29, ISSN:0939-6411 DOI

Cirri, M.; Maestrelli, F.; Mennini, N.; Mura, P. (2015). Combined use of bile acids and aminoacids to improve permeation properties of acyclovir. INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 490, pp. 351-359, ISSN:0378-5173 DOI Accesso ONLINE all'editore

Maestrelli, F.; Zerrouk, N.; Cirri, M.; Mura, P. (2015). Comparative evaluation of polymeric and waxy microspheres for combined colon delivery of ascorbic acid and ketoprofen. INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 485, pp. 365-373, ISSN:0378-5173 DOI Accesso ONLINE all'editore

Mura, P; Bragagni, M; Mennini, N; Cirri, M; Maestrelli, F. (2014). Development of liposomal and microemulsion formulations for transdermal delivery of clonazepam: Effect of randomly methylated β-cyclodextrin. INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 475, pp. 306-314, ISSN:0378-5173 DOI Accesso ONLINE all'editore

Cirri, M.; Roghi, A.; Mura, P.; Giorni, G. (2013). Innovative formulazioni liquide a base di propranololo a confronto con le attuali formulazioni nella terapia pediatrica. GIORNALE ITALIANO DI FARMACIA CLINICA, vol. 27, pp. 354-354, ISSN:1120-3749 DOI

F.Maestrelli; M.Cirri; N.Mennini; M.Bragagni; N.Zerrouk; P.Mura (2012). Influence of cross-linking agent type and chitosan content on the performance of pectinate-chitosan beads aimed for colon-specific drug delivery. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, vol. 1, pp. 1-10, ISSN:0363-9045 DOI

M. Cirri; M. Bragagni; N. Mennini; P. Mura (2012). Development of a new delivery system consisting in "drug-in cyclodextrin- in nanostructured lipid carriers" for ketoprofen topical delivery. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 80, pp. 46-53, ISSN:0939-6411 DOI

N.Mennini; S.Furlanetto; M.Cirri; P.Mura (2012). Quality by Design approach for developing Chitosan-Ca-alginate microspheres for colon delivery of Celecoxib-hydroxypropyl-beta-cyclodextrin-PVP complex.. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 80, pp. 67-75, ISSN:0939-6411 DOI

M. Bragagni; N. Mennini; F. Maestrelli; M. Cirri; P. Mura (2012). Comparative study of liposomes, transfersomes and ethosomes as carriers for improving topical delivery of celecoxib. DRUG DELIVERY, vol. 19, pp. 354-361, ISSN:1071-7544 DOI

P. Mura; M. Valleri; M. Cirri; N. Mennini (2012). New solid self-microemulsifying systems to enhance dissolution rate of poorly water soluble drugs. PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, vol. 17, pp. 277-284, ISSN:1083-7450 DOI

F. Maestrelli; M. Cirri; N. Mennini; N. Zerrouk; P. Mura (2011). Improvement of oxaprozin solubility and permeability by the combined use of cyclodextrin, chitosan, and bile components. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 78, pp. 385-393, ISSN:0939-6411 DOI

S. Furlanetto; M. Cirri; G. Piepel; N. Mennini; P. Mura (2011). Mixture experiment methods in the development and optimization of microemulsion formulations. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 55, pp. 610-617, ISSN:0731-7085 DOI

Paola Angela Mura; Giovanna Corti; Marzia Cirri; Francesca Maestrelli; Natascia Mennini; Marco Bragagni (2010). Development of mucoadhesive films for buccal administration of flufenamic acid: Effect of cyclodextrin complexation.. JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 99, pp. 3019-3029, ISSN:0022-3549 DOI

M. Cirri; F.Maestrelli; N.Mennini; P.Mura (2009). Physical-chemical characterization of binary and ternary systems of ketoprofen with cyclodextrins and phospholipids. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 50, pp. 683-689, ISSN:0731-7085 DOI

Cirri, Marzia; Maestrelli, Francesca; Mennini, Natascia; Mura, PAOLA ANGELA (2009). Influence of the preparation method on the physical-chemical properties of ketoprofen-cyclodextrin-phosphatidylcholine ternary systems. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 50, pp. 690-694, ISSN:0731-7085 DOI

M. Cirri; M. Righi; F.Maestrelli; M. Valleri; P.Mura; (2009). Development of glyburide fast-dissolving tablets based on the combined use of cyclodextrins and polymers. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, vol. 35, pp. 73-82, ISSN:0363-9045 DOI

F.Maestrelli; M.Cecchi; M.Cirri; G.Capasso; N.Mennini; P.Mura (2009). Comparative study of oxaprozin complexation with natural and chemically-modified cyclodextrins in solution and in the solid state. JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, vol. 63, pp. 17-25, ISSN:1388-3127 DOI

G. Corti; M. Cirri; F. Maestrelli; N. Mennini; P. Mura (2008). Sustained release matrix tablets of metformin hydrochloride in combination with triacetyl-ß-cyclodextrin. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 68, pp. 303-309, ISSN:0939-6411 DOI Accesso ONLINE all'editore

Maestrelli, Francesca; Zerrouk, Naima; Cirri, Marzia; Mennini, Natascia; Mura, PAOLA ANGELA (2008). Microspheres for colonic delivery of ketoprofen-hydroxypropyl-ß-cyclodextrin complex. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 34, pp. 1-11, ISSN:0928-0987 DOI

G. Corti; F. Maestrelli; M. Cirri; P. Mura; N. Zerrouk (2008). Dissolution and permeation properties of Naproxen from solid-state systems with chitosan. DRUG DELIVERY, vol. 15, pp. 303-312, ISSN:1071-7544 DOI

Maestrelli, Francesca; Cirri, Marzia; Corti, Giovanna; Mennini, Natascia; Mura, PAOLA ANGELA (2008). Development of enteric-coated calcium pectinate microspheres intended for colonic drug delivery. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 69, pp. 508-518, ISSN:0939-6411 DOI

A. Al-Marzouqi; B. Jobe; G. Corti; M. Cirri; P. Mura (2007). Physicochemical characterization of drug-cyclodextrin complexes prepared by supercritical carbon dioxide and by conventional techniques. JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, vol. 57, pp. 223-231, ISSN:1388-3127, Kluwer Academic Publishers:Journals Department, PO Box 322, 3300 AH Dordrecht Netherlands:011 31 78 6576050, EMAIL: frontoffice@wkap.nl, kluweronline@wkap.nl, INTERNET: http://www.kluwerlaw.com, Fax: 011 31 78 6576254: DOI

G.Corti; G.Capasso; F. Maestrelli; M.Cirri; P. Mura (2007). Physical chemical characterization of binary systems of metformin hydrochloride with triacetyl-β-cyclodextrin. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 45, pp. 480-486, ISSN:0731-7085, American Association fo Pharmaceutical Scientists:2107 Wilson Boulevard, Suite 700:Arlington, VA 22201:(703)243-2800, EMAIL: aaps@aaps.org, INTERNET: http://www.aaps.org, Fax: (703)243-9650: DOI

P. Corvi Mora; M. Cirri; P. Mura (2007). Development of a sustained-release matrix tablet formulation of DHEA as ternary complex with alpha-cyclodextrin and glycine. JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, vol. 57, pp. 699-704, ISSN:1388-3127, Kluwer Academic Publishers:Journals Department, PO Box 322, 3300 AH Dordrecht Netherlands:011 31 78 6576050, EMAIL: frontoffice@wkap.nl, kluweronline@wkap.nl, INTERNET: http://www.kluwerlaw.com, Fax: 011 31 78 6576254: DOI

P. Mura; G. Corti; F. Maestrelli; M. Cirri (2007). The influence of chitosan on cyclodextrin complexing and solubilizing abilities towards drugs. JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, vol. 59, pp. 307-313, ISSN:1388-3127, Kluwer Academic Publishers:Journals Department, PO Box 322, 3300 AH Dordrecht Netherlands:011 31 78 6576050, EMAIL: frontoffice@wkap.nl, kluweronline@wkap.nl, INTERNET: http://www.kluwerlaw.com, Fax: 011 31 78 6576254: DOI

M. Cirri; P. Mura; P. Corvi Mora (2007). Liquid spray formulations of xibornol using self-microemulsifying drug delivery systems. INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 340, pp. 84-91, ISSN:0378-5173, Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598: DOI

M. CIRRI; M. VALLERI; F. MAESTRELLI; G. CORTI; P. MURA (2007). Fast-dissolving tablets of glyburide based on ternary solid dispersions with PEG 6000 and surfactants. DRUG DELIVERY, vol. 14, pp. 247-255, ISSN:1521-0464, Academic Press;Taylor & Francis: DOI

G. CORTI; F. MAESTRELLI; M. CIRRI; S. FURLANETTO; P. MURA (2006). Development and evaluation of an in vitro method for prediction of human drug absorption: I. Assessment of artificial membrane composition.. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 27, pp. 346-353, ISSN:0928-0987

N. ZERROUK; G. CORTI; S. ANCILLOTTI; F. MAESTRELLI; M. CIRRI; P. MURA (2006). Influence of cyclodextrins and chitosan, separately or in combination, on glyburide solubility and permeability. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 62, pp. 241-246, ISSN:0939-6411, Editore attuale: ELSEVIER SCIENCE BV, PO BOX 211, AMSTERDAM, NETHERLANDS, 1000 AE. Medpharm Scientific Publishers GmBH:Postfach 101061, D-70009 Stuttgart Germany:011 49 711 25820, EMAIL: service@medpharm.de, INTERNET: http://www.medpharm.de, Fax: 011 49 711 2582290:

M. CIRRI; F. MAESTRELLI; G. CORTI; S. FURLANETTO; P. MURA (2006). Simultaneous effect of cyclodextrin complexation, pH, and hydrophilic polymers on naproxen solubilization. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 42, pp. 126-131, ISSN:0731-7085, American Association fo Pharmaceutical Scientists:2107 Wilson Boulevard, Suite 700:Arlington, VA 22201:(703)243-2800, EMAIL: aaps@aaps.org, INTERNET: http://www.aaps.org, Fax: (703)243-9650:

S. FURLANETTO; M. CIRRI; F. MAESTRELLI; G. CORTI; P. MURA (2006). Study of formulation variables influencing the drug release rate from matrix tablets by experimental design. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 62, pp. 77-84, ISSN:0939-6411, Editore attuale: ELSEVIER SCIENCE BV, PO BOX 211, AMSTERDAM, NETHERLANDS, 1000 AE. Medpharm Scientific Publishers GmBH:Postfach 101061, D-70009 Stuttgart Germany:011 49 711 25820, EMAIL: service@medpharm.de, INTERNET: http://www.medpharm.de, Fax: 011 49 711 2582290:

G.CORTI; F. MAESTRELLI; M.CIRRI; N.ZERROUK; P.MURA (2006). Development and evaluation of an in vitro method for prediction of human drug absorption: II. Demonstration of the method suitability. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 27, pp. 354-362, ISSN:0928-0987, Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598:

G. CORTI; F. MAESTRELLI; M. CIRRI; P. MURA (2006). Proprietà biofarmaceutiche e problemi di biodisponibilità: test in vitro. NCF. NOTIZIARIO CHIMICO E FARMACEUTICO, vol. 14, pp. 86-88, ISSN:0393-3733

P. CORVI MORA; M. CIRRI; P. MURA (2006). Differential scanning calorimetry as a screening technique in compatibility studies of DHEA extended release formulations. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 42, pp. 3-10, ISSN:0731-7085, American Association fo Pharmaceutical Scientists:2107 Wilson Boulevard, Suite 700:Arlington, VA 22201:(703)243-2800, EMAIL: aaps@aaps.org, INTERNET: http://www.aaps.org, Fax: (703)243-9650:

P. MURA; S. FURLANETTO; M. CIRRI; F. MAESTRELLI; G. CORTI; S. PINZAUTI (2005). Interaction of naproxen with ionic cyclodextrins in aqueous solution and in the solid state.. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 37, pp. 987-994, ISSN:0731-7085

A. CEBALLOS; M. CIRRI; F. MAESTRELLI; G. CORTI; P. MURA (2005). Influence of formulation and process variables on in vitro release of theophylline from directly-compressed Eudragit matrix tablets. IL FARMACO, vol. 60, pp. 913-918, ISSN:0014-827X, Attuale:ELSEVIER SCIENCE SA, PO BOX 564, LAUSANNE, SWITZERLAND, 1001 Societa Chimica Italiana:Viale Liegi 48, 00198 Rome Italy:011 39 06 8549691, EMAIL: soc.chim.it@agora.stm.it, Fax: 011 39 06 8548734: DOI

M.D. VEIGA; M. MERINO; M. CIRRI; F. MAESTRELLI; P. MURA (2005). Comparative study on triclosan interactions in solution and in the solid state with natural and chemically modified cyclodextrins. JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, vol. 53, pp. 77-83, ISSN:1388-3127, Kluwer Academic Publishers:Journals Department, PO Box 322, 3300 AH Dordrecht Netherlands:011 31 78 6576050, EMAIL: frontoffice@wkap.nl, kluweronline@wkap.nl, INTERNET: http://www.kluwerlaw.com, Fax: 011 31 78 6576254: DOI

S. Furlanetto; S. Orlandini; M. Cirri; A.M. Marras; B. Campisi (2005). Les plans d’experiences des melanges dans l’optimisation d’un systeme de microemulsion par l’analyse d’electrophorese capillaire-Mixture design in the optimization of a microemulsion system for capillary electrophoresis analysis. In: 30 ans de la Méthodologie de la Recherche Expérimentale, Aix en Provence, 2-3 Giugno 2005, 30 ans de la Méthodologie de la Recherche Expérimentale, pp. 128-128.

S. FURLANETTO; S. ORLANDINI; A.M. MARRAS; M. CIRRI; S. PINZAUTI (2005). Mixture design in the optimization of a microemulsion system for EKC determination of ketorolac and related impurities. In: 16th International Symposium on Pharmaceutical and Bioanalytical Analysis-PBA 2005, Baltimore, USA, 28-31 Agosto 2005, 16th International Symposium on Pharmaceutical and Bioanalytical Analysis-PBA 2005, pp. L08-4-L08-4.

S. FURLANETTO; S. ORLANDINI; M. CIRRI; A.M. MARRAS; P. MURA; S. PINZAUTI (2005). Experimental design in the study of microemulsions. Use of a new oil phase for MEEKC analysis. In: 11th Meeting on Recent Developments in Pharmaceutical Analysis-RDPA 2005, Rimini, Italy, 25-28 Settembre 2005, 11th Meeting on Recent Developments in Pharmaceutical Analysis-RDPA 2005, pp. 89-89.

Cirri, Marzia; Maestrelli, Francesca; Orlandini, Serena; Furlanetto, Sandra; Pinzauti, Sergio; Mura, PAOLA ANGELA (2005). Determination of stability constant values of flurbiprofen-cyclodextrin complexes using different techniques. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 37, pp. 995-1002, ISSN:0731-7085 DOI

P. MURA; S. FURLANETTO; M. CIRRI; F. MAESTRELLI; A.M. MARRAS; S. PINZAUTI (2005). Optimization of glibenclamide tablet composition through the combined use of Differential Scanning Calorimetry and D-optimal mixture experimental design.. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 37, pp. 65-71, ISSN:0731-7085

P. MURA; J.R. MOYANO; M.L. GONZALEZ RODRIGUEZ; A.M. RABASCO; M. CIRRI; F. MAESTRELLI (2005). Characterization and dissolution properties of ketoprofen in binary and ternary solid dispersions with polyethylene glycol and surfactants. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, vol. 31, pp. 425-434, ISSN:0363-9045, attuale: TAYLOR & FRANCIS INC, 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, USA, PA, 19106 Precedente Marcel Dekker Incorporated:270 Madison Avenue:New York, NY 10016:(800)228-1160, (212)696-9000, EMAIL: bookorders@dekker.com, INTERNET: http://www.dekker.com, Fax: (212)685-4540:

M. CIRRI; C. RANGONI; F. MAESTRELLI; G. CORTI; P. MURA (2005). Development of fast-dissolving tablets of flurbiprofen- cyclodextrin complexes. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, vol. 31, pp. 697-707, ISSN:0363-9045, attuale: TAYLOR & FRANCIS INC, 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, USA, PA, 19106 Precedente Marcel Dekker Incorporated:270 Madison Avenue:New York, NY 10016:(800)228-1160, (212)696-9000, EMAIL: bookorders@dekker.com, INTERNET: http://www.dekker.com, Fax: (212)685-4540:

P. MURA; G.P. BETTINETTI; M. CIRRI; F. MAESTRELLI; M. SORRENTI; L. CATENACCI (2005). Solid state characterization and dissolution properties of naproxen-arginine-hydroxypropyl-B-cyclodextrin ternary systems. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 59, pp. 99-106, ISSN:0939-6411, Editore attuale: ELSEVIER SCIENCE BV, PO BOX 211, AMSTERDAM, NETHERLANDS, 1000 AE. Medpharm Scientific Publishers GmBH:Postfach 101061, D-70009 Stuttgart Germany:011 49 711 25820, EMAIL: service@medpharm.de, INTERNET: http://www.medpharm.de, Fax: 011 49 711 2582290: DOI Accesso ONLINE all'editore

P. Mura; A.L. Ceballos; M. Cirri; F. Maestrelli (2004). 120) Effect of cyclodextrin complexation on theophylline release from coated polymeric matrix tablets. In: 12th International Cyclodextrin Symposium, Montpellier, 16-19/05/2004, Association de pharmacie galénique industrielle (APGI), pp. 819-822.

M. VALLERI; P. MURA; F. MAESTRELLI; M. CIRRI; R. BALLERINI (2004). Development and evaluation of glyburide fast dissolving tablets using solid dispersion technique. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, vol. 30, pp. 525-534, ISSN:0363-9045, attuale: TAYLOR & FRANCIS INC, 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, USA, PA, 19106 Precedente Marcel Dekker Incorporated:270 Madison Avenue:New York, NY 10016:(800)228-1160, (212)696-9000, EMAIL: bookorders@dekker.com, INTERNET: http://www.dekker.com, Fax: (212)685-4540:

S. Romero; P. Bustamante; B. Escalera; P. Mura; M. Cirri (2004). Influence of solvent composition on the solid phase at equilibrium with saturated solutions of quinolones in different sovent mixtures. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 35, pp. 715-726, ISSN:0731-7085, American Association fo Pharmaceutical Scientists:2107 Wilson Boulevard, Suite 700:Arlington, VA 22201:(703)243-2800, EMAIL: aaps@aaps.org, INTERNET: http://www.aaps.org, Fax: (703)243-9650:

Alvarez-Fuentes; Fernández-Arévalo; González-Rodríguez; M. Cirri; P. Mura (2004). Development of enteric-coated timed-release matrix tablets for colon targeting. JOURNAL OF DRUG TARGETING, vol. 12, pp. 607-612, ISSN:1061-186X, Taylor & Francis Limited:Rankine Road, Basingstoke RG24 8PR United Kingdom:011 44 1256 813035, EMAIL: madeline.sims@tandf.co.uk, info@tandf.co.uk, INTERNET: http://www.tandf.co.uk, Fax: 011 44 1256 330245: DOI

M. Cirri; F. Maestrelli; C. Rangoni; S. Furlanetto; S. Orlandini; S. Pinzauti; P. Mura (2004). Determination of stability constant values of flurbiprofen-cyclodextrin complexes using different techniques. In: 15th International Symposium on Pharmaceutical and Biomedical Analysis-PBA 2004, Firenze, 2-6 Maggio 2004, 15th International Symposium on Pharmaceutical and Biomedical Analysis-PBA 2004, pp. 139-139.

M. Cirri; P. Mura; A.M. Rabasco; J.M. Ginés; J.R. Moyano; M.L. Gònzalez-Rodrìguez (2004). Characterization of ibuproxam binary and ternary dispersions with hydrophilic carriers. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, vol. 30, pp. 65-74, ISSN:0363-9045, attuale: TAYLOR & FRANCIS INC, 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, USA, PA, 19106 Precedente Marcel Dekker Incorporated:270 Madison Avenue:New York, NY 10016:(800)228-1160, (212)696-9000, EMAIL: bookorders@dekker.com, INTERNET: http://www.dekker.com, Fax: (212)685-4540:

N. Zerrouk; S. Ancillotti; F. Maestrelli; M. Cirri; P. Mura (2004). Effects of cyclodextrins and chitosan on gliburide dissolution and permeability through intestinal epithelial cells (Caco 2). In: 12th International Cyclodextrin Symposium, Montpellier, 16-19/05/2004, Association de pharmacie galénique industrielle (APGI), pp. 871-874.

R. POMPONIO; R. GOTTI; J. FIORI; V. CAVRINI; P. MURA; M. CIRRI; F. MAESTRELLI (2004). Photostability studies on nicardipine-cyclodextrin complexes by capillary electrophoresis.. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 35, pp. 267-275, ISSN:0731-7085, American Association fo Pharmaceutical Scientists:2107 Wilson Boulevard, Suite 700:Arlington, VA 22201:(703)243-2800, EMAIL: aaps@aaps.org, INTERNET: http://www.aaps.org, Fax: (703)243-9650:

P. Bustamante; B. Escalera; S. Romero; M. Cirri; P. Mura (2004). CHARACTERIZATION OF THE SOLID PHASES OF PARACETAMOL AND FENAMATES AT EQUILIBRIUM IN SATURATED SOLUTIONS. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, vol. 77, pp. 541-554, ISSN:1388-6150

P. Corvi Mora; M. Cirri; F. Carli; P. Mura (2004). Physicochemical characterization of DHEA-cyclodextrin-glycine ternary systems. In: 12th International Cyclodextrin Symposium, Montpellier, 16-19/05/2004, Association de pharmacie galénique industrielle (APGI), pp. 471-474.

M.CIRRI; F.MAESTRELLI; S.FURLANETTO; P.MURA (2004). Solid state characterization of glyburide-cyclodextrin co-ground products. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, vol. 77, pp. 413-422, ISSN:1388-6150, Akademiai Kiado:Prielle Kornelia U-19, H 1117 Budapest Hungary:011 36 1 4648222, 011 36 1 4648282, 011 36 1 4648282, EMAIL: journals@akkrt.hu, kiss.s@akkrt.hu, INTERNET: http://www.akkrt.hu/en/, Fax: 011 36 1 4648221:

P. Mura; F. Maestrelli; M. Cirri (2003). Ternary systems of naproxen with hydroxypropyl-ß-cyclodextrin and aminoacids. INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 260, pp. 293-302, ISSN:0378-5173, Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598: DOI Accesso ONLINE all'editore

P. Corvi Mora; M. Cirri; B. Allolio; F. Carli; P. Mura (2003). Enhancement of dehydroepiandrosterone solubility and bioavailability by ternary complexation with a-cyclodextrin and glycine. JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 92, pp. 2177-2184, ISSN:0022-3549, -JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, USA, NJ, 07030 -American Pharmacists Association:2215 Constitution Avenue Northwest:Washington, DC 20037:(800)237-2742, (202)429-7518, EMAIL: japha@mail.aphanet.org, INTERNET: http://www.aphanet.org, Fax: (202)783-2351: DOI

P. Mura; F. Maestrelli; M. Cirri; M. L. González Rodríguez; A.M. Rabasco Alvarez (2003). Development of enteric-coated pectin-based matrix tablets for colonic delivery of theophylline. JOURNAL OF DRUG TARGETING, vol. 11, pp. 365-371, ISSN:1061-186X, Taylor & Francis Limited:Rankine Road, Basingstoke RG24 8PR United Kingdom:011 44 1256 813035, EMAIL: madeline.sims@tandf.co.uk, info@tandf.co.uk, INTERNET: http://www.tandf.co.uk, Fax: 011 44 1256 330245: DOI Accesso ONLINE all'editore

P. MURA; F. MAESTRELLI; M. CIRRI; S. FURLANETTO; S. PINZAUTI (2003). Differential Scanning calorimetry as an analytical tool in the study of drug-cyclodextrin interactions. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, vol. 73, pp. 635-646, ISSN:1388-6150

P. Mura; M. Cirri; M.T. Faucci; J.M. Ginès-Dorado; G.P. Bettinetti (2002). INVESTIGATION OF THE EFFECTS OF GRINDING AND CO-GRINDING ON PHYSISCOCHEMICAL PROPERTIES OF GLISENTIDE. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 30, pp. 227-237, ISSN:0731-7085 DOI

Marzia CIRRI

Biography

Associate Professor at the Department of Chemistry (DICUS), Univ. of Florence.

National academic qualification for full professor. Author of 86 publications (84 research papers and 2 reviews) (SCOPUS h index=41; >3700 citations) in international and national journals in the field of pharmaceutical technology and >100 communications (oral and poster) at national and international conferences. Author of a book chapter and a contribution translation of a book chapter. Referee for numerous international scientific journals and member of the editorial board of scientific journals.

Co-supervisor of doctoral theses, supervisor and co-supervisor of experimental degree theses. Erasmus teaching activity: Univ. Granada, Madrid and Zagreb. Participated in the organization of symposiums and workshops. Affiliated to various scientific societies and associations. Has held the positions of PRIN Reviewer and VQR Reviewer 2015-19.

UniFi academic roles: Member of: CHIM/09 Examination Commission, Degree Judging Commissions in C.T.F., Judging Commission for Qualification to Practice as a Pharmacist, Commission for Research Grants and Research Scholarships, Competition Commission for RTDA, CPDS of the SSSU, Departmental Instrumentation Commission, Judging Commission for the Practical Evaluation Test (PPV) three-year period 2024-2026

Research lines: development and characterization of innovative formulations aimed at improving the bioavailability of the drug, by complexing the drug with cyclodextrins, solid dispersions and mechanically activated systems with polymeric carriers and/or with cyclodextrins; drug vectorization in different types of colloidal carriers (solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), micelles, liposomes, niosomes, polymeric nanoparticles, etc.) also exploiting combined strategies with the use of cyclodextrins (mixed systems "drug-in-cyclodextrin-in-lipid nanocarriers") for oral and topical use; development of bioadhesive and/or thermosensitive buccal, nasal or vaginal delivery systems for local or systemic action; development and characterization of innovative pediatric formulations.

Marzia CIRRI

Curriculum

Associate Professor CHEM-08/A Dept. Chemistry (DICUS), School of Human Health Sciences, Univ. Florence, Titular of the courses ‘Implantations of Pharmaceutical Industry”

2015-2019: Assistant Professor CHIM/09, Dept. Chemistry, School of Human Health Sciences, Univ. Florence

2018: National academic qualification for full professor.

Formation

2000: Degree in Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, Univ. Florence

2000: Qualification to practice as Pharmacist

2001 – 2004: PhD in Drug Chemistry and Technology in the Pharmaceutical Technology field, Dept. of Pharmaceutical Sciences, Faculty of Pharmacy, Univ. Florence (Italy). Title: “Development of innovative formulations aimed to enhance the drug bioavailability”.

2004-2010: five years Post-Doc Research Fellowship in the Pharmaceutical Technology field, Dept. of Pharmaceutical Sciences, Faculty of Pharmacy Univ. Florence. Title: “Enhancement of the biopharmaceutical properties of drugs and preformulation studies.”

2010: Post-Doc grant in the Pharmaceutical Technology field, Dept. of Pharmaceutical Sciences, Faculty of Pharmacy Univ. Florence. Title: “Innovative formulations aimed to improve the physico-chemical properties of drugs”.

2011-2013: Research and consulting activity in the Pharmaceutical Technology field in collaboration with pharmaceutical companies

Teaching activities in Italy

2002: Training course for Pharmacists entitled:”Matrix systems for controlled drug delivery”, Arezzo (Italy)

2001-2012: Teaching assistant activity for practice exercises of Pharmaceutical Technology Lab., Faculty of Pharmacy, University of Florence (Italy);

2001-2009: Teaching assistant activity for the course: ”Pharmaceutical Technology, Socio-Economics and Law”, Faculty of Pharmacy, University of Florence (Italy);

2010-2014: Adjunct professor for the courses :”Pharmaceutical Technology, Socio-Economics and Law” and 'Implantations of the pharmaceutical Industry”, University of Florence (Italy)

2018: Teaching activity at 6^th NanoFar School: European Doctorate in nanomedicine and pharmaceutical innovation, Erasmus Mundus Programme, Univ. Modena and Reggio-Emilia, 11^th-15^th June 2018. “Nanostructured lipid systems as safe and effective delivery systems for oral drug administration in paediatric therapy”

Teaching activities abroad

a.y. 2015-2016 Teaching staff activity, Dpt. Pharmaceutical Chemistry, Faculty of Pharmacy and Biochemistry, Univ. Zagreb

a.y. 2016-2017 Teaching staff activity, Dpto de Farmacia y Tecnologia Farmaceutica, Facultad de Farmacia, Universidad Complutense de Madrid

a.y. 2017-2018 Teaching staff activity, Dept. Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Spagna, invited by Prof. César Viseras Iborra

Other activities

VQR referee

PRIN referee

Referee for International scientific Journals

Member of scientific society and associations (ADRITELF, CRS Italian Chapter, A.It.U.N-AAPS Italian University Network, EPTRI (European Paediatric Translational Research Infrastructure))

Assistant supervisor of experimental thesis in Pharmaceutical Technology, Faculty of Pharmacy, University of Florence (Italy), since 2003

Member of the Degree Committees for Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Florence (Italy), since 2003

Supervisor of experimental thesis in Pharmaceutical Technology, since 2016

Supervisor of international experimental thesis (2017)

Member of boards of examiners for the following courses, Faculty of Pharmacy, University of Florence (Italy): Pharmaceutical Technology, Socio-Economics and Law” and “Applied Pharmaceutical Chemistry” since 2003; “Systems of the Pharmaceutical Industry”, since 2010

Head of boards of examiners for the course “Systems of the Pharmaceutical Industry”, School of Human Health Sciences, University of Florence (Italy) since 2015

Editorial Board Member of:

-Pharmaceutics (ISSN 1999-4923)

-International Journal of Pharma Research and Health Sciences (IJPRHS), eISSN : 2348-6465

Guest Editor of Special Issues:

-“Cyclodextrin-based materials and applications”, ‘Applied Sciences’ Multidisciplinary Digital Publishing Institute (MDPI) ISSN 2076-3417
-"Cyclodextrins in Drug Formulation and Delivery", ‘Pharmaceutics’ - Multidisciplinary Digital Publishing Institute (MDPI) ISSN:1999-4923

-"Cyclodextrins in Drug Delivery", ‘Pharmaceutics’ - Multidisciplinary Digital Publishing Institute (MDPI) ISSN:1999-4923

Poster awards

- Retsch Scientific Challenge 2024 Award: Mixer Mill MM200 for the project: 'Cogrinding: a green and safe approach for drug taste masking in the pediatric oral therapy'

- CRS Italy Chapter Award 2017 “Thermosensitive gels for pediatric mucositis: preformulation studies”

- 'Top 20 article' (n.1 in 2015; n.8 in 2014) for the publication: M. Cirri, M. Bragagni, N. Mennini, P. Mura “Development of a new delivery system consisting in ‘‘drug – in cyclodextrin – in nanostructured lipid carriers’’ for ketoprofen topical delivery” Eur. J. Pharm. Biopharm. 80 (2012) 46-53

- Vespucci Award 2006 (Ricerca, Innovazione Etica in Toscana) for "Smart-Test" project;

- "Best poster" Award: “Development and evaluation of an artificial membrane for high throughput assessment of drug absorption potential” 43° Simposio AFI 2003. Perugia, 11-13 June 2003.

Scientific activities

Author of 86 papers (h index=41; >3600 citations) published in international and national journals in the field of Pharmaceutical Technology and >100 oral and poster presentations at International and National Symposia and Workshops. Author of a book chapter and a contribution in a book chapter (translation).

Research lines:

Development and characterization of innovative formulations aimed to enhance the drug bioavailability.

Improvement of the unfavorable characteristics of drugs through drug complexation with cyclodextrins; development, characterization and evaluation of solid dispersions and mechanically activated systems with polymeric carriers and/or with cyclodextrins. Preparation, physicochemical characterization and biopharmaceutical evaluation of such systems.

Preparation, characterization and biopharmaceutical evaluation of innovative formulations of solid, semi-solid and liquid dosage forms (matrix systems, colonic delivery systems, topical and transdermal gels, microemulsions, SMEDDS, lipid nanoparticles).

Preparation, physical-chemical characterization and biopharmaceutical evaluation of mixed systems ‘drug-in-cyclodextrin-in-lipidic nanocarriers’ for oral and topical use.

Development and characterization of innovative pediatric formulations.

Stability studies; compatibility studies between drug and excipients.