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Livia Marrazzo consegue, con lode, la laurea in Fisica presso l’Università degli Studi di Napoli "Federico II" nel 2003.
Nel 2008 consegue, con lode, il diploma di specializzazione in Fisica Medica presso l’Università degli Studi di Firenze.
È attualmente Dirigente Fisico presso l’Azienda Ospedaliero-Universitaria Careggi di Firenze e Ricercatore a Tempo Determinato di tipo B (RTDB) presso il Dipartimento di Scienze Biomediche, Sperimentali e Cliniche dell’Università degli Studi di Firenze.
Svolge attività clinica e di ricerca in ambito radioterapico, con particolare riferimento alle tecniche di pianificazione avanzate ed automatiche del trattamento radioterapico, alla gestione della patologia mammaria e al Radiotherapy Quality Assurance (RTQA) in trial clinici multicentrici.

Curriculum vitae et studiorum

Livia Marrazzo

Personal information

Place of birth: Torre del Greco, Napoli (Italia)

Nationality: Italian

Email: livia.marrazzo@unifi.it

Education

2008: Medical Physics certification, University of Florence (Italy).

2004: MSc in Radiation Biology, University College London (UK).

2003: MSc in Physics, University of Naples (Italy).

Work experience

Current position: Assistant Professor at the Department of Experimental and Clinical Biomedical Sciences, University of Florence, Italy (since October 2022).

Medical Physicist, Azienda Ospedaliero-Universitaria Careggi, Firenze (since January 2009). Working at the Medical Physics Unit, Radiotherapy, of the University Hospital Careggi.

Main skills:

-       Photon and electron beam dosimetry for clinical applications;

-       Quality Assurance on linear accelerators, brachytherapy sources, Tomotherapy, imaging devices (CT scanners, portal imaging devices, Cone Beam kV CT, laser-camera based surface acquisition systems);

-       Treatment planning with 3DCRT, IMRT, VMAT techniques;

-       Treatment planning and quality assurance in Gamma Knife;

-       Commissioning of radiotherapy linear accelerators;

-       Commissioning and use of several treatment planning systems for 3DCRT, stereotactic RT, intensity modulated RT and intensity modulated arc therapy;

-       Automated planning, development and validation;

-       Breast cancer treatment;

-       Patient-based dosimetric verification of IMRT treatments with different detectors;

-       Dosimetric characterization of new developed detectors;

-       Use of Record & Verify software;

-       Use of PACS systems;

-       Information systems support.

March 2005 - December 2008: Scholarship on “Physical Methods and Procedures for High Conformity Radiotherapy Treatments”, University of Florence.

The activity mainly concerned the development and the dosimetric characterization of a 2D silicon detector for patient-based dose verification in radiotherapy. The work was part of the MAESTRO (Methods and Advanced Equipment for Simulation and Treatment in Radio Oncology) European Project. The work also included the characterization of radiochromic films (GAFCHROMIC EBT) and the design and manufacture of a water phantom for dosimetric verification in radiotherapy.

The research activity also regarded the PRIN-PRIMA project ("PRoton IMAging and conformal radiotherapy dosimetry by segmented silicon detectors"), aiming to the design and manufacture of a proton Computed Tomography (pCT) apparatus for patient positioning verification in Proton Therapy. I have been involved in the Monte Carlo simulation of the experimental setup and in the analysis of the experimental data acquired at Loma Linda Medical Center.

Teaching appointments

Since 2014: Habilitation (’abilitazione’) for the position of Associate Professor in Physics (FIS/07).

Since 2022: Coordinator of the Basic Physics Course in the first-degree master for Medical Radiology Techniques for Imaging and Radiotherapy, University of Florence (2 university credits)

Since 2022: Teaching in the Applied Physics Course in the master for Dentistry and Dental Prosthesis, University of Florence (1 university credit)

Since 2022: Teaching in the Physics, Statistics and Computer Science Course in the master for Neurophysiopathology Techniques, Biomedical Laboratory Techniques and Dietistics, University of Florence (2 university credits)

2009 - 2022: Contract professor in “Mathematics, Physics, Statistic and Informatics”, in the first-degree course for “Radiographer for Imaging and Radiotherapy”, University of Florence.

Since 2009: Teaching in the Postgraduate School in Medical Physics in the Course on Quality Assurance on Linear Accelerators and Patient-based Dosimetric Verification.

2015 - 2019: Teaching in the Postgraduate Master in Radiotherapy for Dosimetrists in the Course in Oncologic Radiotherapy: technological, therapeutic and dosimetric aspects, University of Florence.

Other professional appointments

19-20^th of February 2024: Scientific Coordinator of the Course on “From Diagnostics to Radiotherapy of breast cancer: state of the art and new perspectives” (Scuola Superiore di Fisica in Medicina Piero Caldirola) held in Florence.

2023: Reviewer of abstracts submitted to the AIFM congress

2023-2024: member of the Scientific Advisory Group for Physics of the ESTRO 2024 Congress

2022-2023: member of the Scientific Advisory Group for Physics of the ESTRO 2023 Congress

Since 2020: Associate Editor for “European Journal of Medical Physics”

21^st August 2020 -20^th September 2021: member as Reviewer Editor of the Editorial Board of “Frontiers in Oncology”

23^rd of September 2019: Scientific Coordinator of the Course on “Dose calculation in external beam radiotherapy” (Scuola Superiore di Fisica in Medicina Piero Caldirola) held in Rome.

2017–2018: Member of the Scientific Committee for Physics in Radiotherapy, 2018 AIFM (Italian Association of Medical Physics) congress

Since 2016: Reviewer of abstracts submitted to the ESTRO congress

Since 2010: Reviewer of manuscripts submitted to many indexed journals such as ’European Journal of Medical Physics’, ’Radiation Measurements’, ’Practical Radiation Oncology’, ’Radiotherapy and Oncology’. Selected as ’Outstanding reviewer’ in 2015 and 2017 for the ’European Journal of Medical Physics’ and in 2016 for ’Radiation Measurements’.

Supervision of students

2023 - University of Florence - Co-supervisor of a specialization thesis in Medical Physics on “DOSIMETRIC AND CLINICAL EVALUATION OF A NEW FULLY AUTOMATED PLANNING SYSTEM FOR WHOLE BREAST IRRADIATION”

2022 – University of Milan - Referee of a specialization thesis in Medical Physics on “COMPREHENSIVE DOSIMETRIC AND CLINICAL EVALUATION OF LEXICOGRAPHIC OPTIMIZATION-BASED PLANNING FOR CERVICAL CANCER”

2012 - University of Florence - Supervisor of a first-degree thesis for Radiographer for Imaging and Radiotherapy on “OPTIMIZATION OF SETUP AND SHIELDING IN TOTAL SKIN ELECTRON THERAPY”

2010 - University of Florence - Supervisor of a first-degree thesis for Radiographer for Imaging and Radiotherapy on “COMPARISON OF TWO MLC DEVICES FOR SRS”

Invited talks, seminars, lectures, and oral communications

1. 7-11 October 2024 – Trieste, Italy – Joint ICTP-IAEA Workshop on Radiation Protection in Image-Guided Radiotherapy (IGRT) – Invited talk – Discussion on Radiological protection for adaptive radiotherapy
2. 12-14 June 2024 – Dijon, France – 62ème Journées Scientifiques, SFPM -Invited talk – Automated planning in clinical practice
3. 12-16 May 2023 – Wien – ESTRO 2023 – Invited talk – Will automation of radiotherapy tasks solve more problems than it causes? Planning automation
4. 8-11 June 2023 – 12° Congresso Nazionale AIFM – Invited talk – Debate on present and future of radiation therapy automated planning systems. Optimization Based techniques are advantageous if compared to Knowledge Based techniques
5. 8-11 June 2023 – 12° Congresso Nazionale AIFM – Oral Communication – Rotational Total Skin Electron Therapy with an in-house built flattening filter
6. 03 February 2023 – Virtual – 14th annual COMP Winter School– Invited talk – Automation in Radiation Therapy Treatment Planning
7. 02 December 2022- AIRO Webinar on Primary and Secondary Liver Neoplasms: contouring and implications in clinical practice - Invited talk – Radiation Therapy Treatment Planning at linac
8. 06-10 May 2022 – Copenhagen – ESTRO 2022 – Invited talk – Keeping automatic planning up to date: How to incorporate changes to dose prescription, technique, and OAR constraints
9. 06-10 May 2022 – Copenhagen – ESTRO 2022 – Oral Communication – Fully automated VMAT technique for radiation therapy of high-risk breast cancer
10. 16-19 June 2021 – 3^rd European Congress of Medical Physics – 11° Congresso Nazionale AIFM – Oral Communication – Feasibility, robustness and dosimetric accuracy of the treatment of face and scalp with helical Tomotherapy
11. 16-19 June 2021 – 3^rd European Congress of Medical Physics – 11° Congresso Nazionale AIFM – Oral Communication – A semi-automatic planning technique for whole breast irradiation with tangential IMRT fields
12. 18 June 2020 – Webinar on Automated Planning organized by TEMA Sinergie – Invited talk – Pinnacle3 AutoPlanning in the treatment of the breast
13. December 2019 – Singapore – ESTRO meets ASIA Congress – Invited talk – Automated planning in clinical practice
14. 31 May 2019 – Florence – Course organized by Careggi University Hospital on “Evaluation of the lens dose following EURATOM directive 2013/59” – Invited talk – Lens dose in radiotherapy
15. October 2018 – Bologna – Elekta user meeting – Invited talk – Automated planning with Monaco TPS
16. October 2018 – Firenze – AIFM course on Stereotactic Body Radiation Therapy: from physics to clinic – Invited talk – Autoplanning in SBRT
17. April 2018 – Bari – X AIFM Congress – Oral communication – Automated planning for VMAT APBI
18. June 2017 – Verona – Corso Caldirola “4D techniques and adaptive radiation therapy” – Invited talk – 4D radiotherapy of the breast
19. May 2017 – Wien – ESTRO36 – Invited talk – Target coverage and dose to organs at risk using different techniques of APBI (EBI, IORT, BT)
20. April 2016 – Torino – ESTRO 35 oral communication – Delivery errors detectability with IQM, a system for real-time monitoring of radiotherapy treatments
21. February 2016 – Perugia – IX AIFM Congress – Oral communication – Dose verification of VMAT hypofractionated lung treatments in moving phantom
22. October 2015 – Florence – Workshop: Image Guided Radiation Therapy (IGRT) and respiratory gating with optical systems
23. March 2014 – Florence – Workshop: "Ray in the Sunrise: Adaptive Radiotherapy” – Invited talk – From gamma to DVH: validation and first clinical applications of 3DVH
24. November 2013 – Torino – VIII AIFM Congress – Oral communication – Patient based dosimetric verification: from gamma to DVH
25. March 2013 – Firenze – ESTRO course on Dose Modelling and Verification for External Beam Radiotherapy – Invited talk – Experience of Florence Medical Physics on patient-based dose verification, with different types of detectors (2D and 3D)
26. November 2012 – Firenze – Workshop on special techniques in radiotherapy – Invited talk – Dosimetric verification for special techniques
27. September 2009 – Reggio Emilia – VI AIFM Congress – Oral communication – Optimization of the acquisition parameters of a kV Cone-Beam CT

Book chapters

Breast cancer Radiation Therapy. A Practical Guide for Technical Applications (editors Orit Kaidar-Person, Icro Meattini, Philip Poortmans), 2022, Springer International Publishing.

Stomach, Duodenum, Liver and Central hepatobiliary tract - Modelling Radiotherapy Side Effects: Practical Applications for Planning Optimisation(editors Tiziana Rancati and Claudio Fiorino), ISBN 9781138198098, 2019, CRC Press.

Publications

1. Marrazzo L, Chilà D, Vanore I, Pellegrini R, Voet P, Di Cataldo V, Meattini I, Zani M, Arilli C, Calusi S, Casati M, Compagnucci A, Talamonti C, Livi L, Pallotta S, Planning Automation for Treatment Techniques Comparison and Robustness Analysis: Tangential Intensity Modulated Radiation Therapy and Volumetric Modulated Arc Therapy for Whole Breast Irradiation, Advances in Radiation Oncology, 2025, https://doi.org/10.1016/j.adro.2025.101719.
2. Meattini I, De Santis MC, Visani L, Scorsetti M, Fozza A, Meduri B, De Rose F, Bonzano E, Prisco A, Masiello V, La Rocca E, Spoto R, Becherini C, Blandino G, Moscetti L, Colciago RR, Audisio RA, Brain E, Caini S, Hamaker M, Kaidar-Person O, Lambertini M, Marrazzo L, Saieva C, Spanic T, Strnad V, Wheelwright S, Poortmans PMP, Livi L; EUROPA Trial Investigators. Single-modality endocrine therapy versus radiotherapy after breast-conserving surgery in women aged 70 years and older with luminal A-like early breast cancer (EUROPA): a preplanned interim analysis of a phase 3, non-inferiority, randomised trial. Lancet Oncol. 2024 Dec 11:S1470-2045(24)00661-2. doi: 10.1016/S1470-2045(24)00661-2. Epub ahead of print. PMID: 39675376.
3. Marrazzo L, Meattini I, Becherini C, Salvestrini V, Visani L, Barletta G, Saieva C, Del Bene MR, Pilato G, Desideri I, Arilli C, Paoletti L, Russo S, Scoccianti S, Martella F, Francolini G, Simontacchi G, Nori Cucchiari J, Pellegrini R, Livi L, Pallotta S., Subclinical cardiac damage monitoring in breast cancer patients treated with an anthracycline-based chemotherapy receiving left-sided breast radiation therapy: subgroup analysis from a phase 3 trial. Radiol Med. 2024 Oct 22. doi: 10.1007/s11547-024-01897-6. Online ahead of print. PMID: 39436588
4. Lastrucci A, Marrazzo L, Meattini I, Simontacchi G, Wandael Y, Talamonti C, Pallotta S, Ricci R, Livi L. Advancing patient setup: A comprehensive scoping review of tattoo-less techniques in radiation therapy. Crit Rev Oncol Hematol. 2024 Sep 20;204:104518. doi: 10.1016/j.critrevonc.2024.104518. Online ahead of print. PMID: 39299409 Review.
5. Lastrucci A, Morelli I, Votta C, Maran I, Iosca N, Monaco IP, Salvestrini V, Desideri I, Marrazzo L, Wandael Y, Cornacchione P, Pallotta S, Giansanti D, Ricci R, Livi L, Bonomo P. Open-Face Masks in Radiotherapy: Enhancing Therapeutic Strategies for Head and Neck and Brain Cancer Patients-A Comprehensive Scoping Review. Cancers (Basel). 2024 Aug 21;16(16):2899. doi: 10.3390/cancers16162899. PMID: 39199669 Free PMC article. Review.
6. Lastrucci A, Esposito M, Serventi E, Marrazzo L, Francolini G, Simontacchi G, Wandael Y, Barra A, Pallotta S, Ricci R, Livi L. Enhancing patient safety in radiotherapy: Implementation of a customized electronic checklist for radiation therapists. Tech Innov Patient Support Radiat Oncol. 2024 May 28;31:100255. doi: 10.1016/j.tipsro.2024.100255. eCollection 2024 Sep. PMID: 38882236 Free PMC article.
7. Piffer S, Greto D, Ubaldi L, Mortilla M, Ciccarone A, Desideri I, Genitori L, Livi L, Marrazzo L, Pallotta S, Retico A, Sardi I, Talamonti C. Radiomic- and dosiomic-based clustering development for radio-induced neurotoxicity in pediatric medulloblastoma. Childs Nerv Syst. 2024 Aug;40(8):2301-2310. doi: 10.1007/s00381-024-06416-6. Epub 2024 Apr 20. PMID: 38642113 Free PMC article.
8. Marrazzo L, Redapi L, Pellegrini R, Voet P, Meattini I, Arilli C, Calusi S, Casati M, Chilà D, Compagnucci A, Talamonti C, Zani M, Livi L, Pallotta S. Fully automated volumetric modulated arc therapy technique for radiation therapy of locally advanced breast cancer. Radiat Oncol. 2023 Oct 30;18(1):176. doi: 10.1186/s13014-023-02364-8. PMID: 37904150 Free PMC article.
9. Marrazzo L, Meattini I, Simontacchi G, Livi L, Pallotta S. Updates on the APBI-IMRT-Florence Trial (NCT02104895) Technique: From the Intensity Modulated Radiation Therapy Trial to the Volumetric Modulated Arc Therapy Clinical Practice. Pract Radiat Oncol. 2023 Jan-Feb;13(1):e28-e34. doi: 10.1016/j.prro.2022.05.010. Epub 2022 Jun 2. PMID: 35659597
10. Pallotta S, Calusi S, Marrazzo L, Talamonti C, Russo S, Esposito M, Fiandra C, Giglioli FR, Pimpinella M, De Coste V, Bruschi A, Barbiero S, Mancosu P, Stasi M, Lisci R. End-to-end test for lung SBRT: An Italian multicentric pilot experience. Phys Med. 2022 Dec;104:129-135. doi: 10.1016/j.ejmp.2022.11.004. Epub 2022 Nov 16. PMID: 36401941
11. Matsui JK, Perlow HK, Facer BD, McCalla A, Marrazzo L, Detti B, Scorsetti M, Clerici E, Scoccianti S, Navarria P, Trifiletti DM, Gondi V, Bovi J, Huang J, Brown PD, Palmer JD. Radiotherapy for elderly patients with glioblastoma: an assessment of hypofractionation and modern treatment techniques. Chin Clin Oncol. 2022 Oct;11(5):38. doi: 10.21037/cco-22-76. PMID: 36336897 Free article.
12. Perlow HK, Prasad RN, Yang M, Klamer B, Matsui J, Marrazzo L, Detti B, Scorsetti M, Clerici E, Arnett A, Beyer S, Ammirati M, Chakravarti A, Raval RR, Brown PD, Navarria P, Scoccianti S, Grecula JC, Palmer JD. Accelerated hypofractionated radiation for elderly or frail patients with a newly diagnosed glioblastoma: A pooled analysis of patient-level data from 4 prospective trials. Cancer. 2022 Jun 15;128(12):2367-2374. doi: 10.1002/cncr.34192. Epub 2022 Mar 22. PMID: 35315512
13. Marrazzo L, Redapi L, Zani M, Calusi S, Meattini I, Arilli C, Casati M, Compagnucci A, Talamonti C, Raspanti D, Pertutti S, Di Cataldo V, Livi L, Pallotta S. A semi-automatic planning technique for whole breast irradiation with tangential IMRT fields. Phys Med. 2022 Jun;98:122-130. doi: 10.1016/j.ejmp.2022.05.001. Epub 2022 May 7. PMID: 35537327
14. Casati M, Piffer S, Calusi S, Marrazzo L, Simontacchi G, Di Cataldo V, Greto D, Desideri I, Vernaleone M, Francolini G, Livi L, Pallotta S. Clinical validation of an automatic atlas-based segmentation tool for male pelvis CT images. Appl Clin Med Phys. 2022 Jan 22:e13507. doi: 10.1002/acm2.13507. Online ahead of print.
15. Meattini I, Becherini C, Boersma L, Kaidar-Person O, Marta GN, Montero A, Offersen BV, Aznar MC, Belka C, Brunt AM, Dicuonzo S, Franco P, Krause M, MacKenzie M, Marinko T, Marrazzo L, Ratosa I, Scholten A, Senkus E, Stobart H, Poortmans P, Coles CE. European Society for Radiotherapy and Oncology Advisory Committee in Radiation Oncology Practice consensus recommendations on patient selection and dose and fractionation for external beam radiotherapy in early breast cancer. Lancet Oncol. 2022 Jan;23(1):e21-e31. doi: 10.1016/S1470-2045(21)00539-8.
16. Pallotta S, Marrazzo L, Calusi S, Castriconi R, Fiorino C, Loi G, Fiandra C., Implementation of automatic plan optimization in Italy: Status and perspectives. Phys Med. 2021 Dec 4;92:86-94. doi: 10.1016/j.ejmp.2021.11.013.
17. Perlow HK, Yang M, Klamer B, Marrazzo L, Detti B, Scorsetti M, Clerici E, Arnett ALH, Beyer S, Ammirati M, Grecula JC, Chakravarti A, Raval R, Navarria P, Scoccianti S, Palmer JD. Dose-Escalated Accelerated Hypofractionation for Patients with a Newly Diagnosed Glioblastoma: A Pooled International Study. Int J Radiat Oncol Biol Phys. 2021 Nov 1;111(3S):S26. doi: 10.1016/j.ijrobp.2021.07.087.
18. Esposito M, Marrazzo L, Vanzi E, Russo S, Pallotta S, Talamonti C. A Validation Method for EPID In Vivo Dosimetry Algorithms. Applied Sciences. 2021; 11(22):10715. https://doi.org/10.3390/app112210715.
19. Arilli C, Zani M, Marrazzo L, Scoccianti S, Casati M, Compagnucci A, Talamonti C, Livi L, Pallotta S. Automatic VMAT technique to treat glioblastoma: A two years' experience. Phys Med. 2021 Oct;90:115-122. doi: 10.1016/j.ejmp.2021.09.015. Epub 2021 Oct 6.
20. Kaidar-Person O, Dahn HM, Nichol AM, Boersma LJ, de Ruysscher D, Meattini I, Pignol JP, Aristei C, Belkacemi Y, Benjamin D, Bese N, Coles CE, Franco P, Ho AY, Hol S, Jagsi R, Kirby AM, Marrazzo L, Marta GN, Moran MS, Nissen HD, Strnad V, Zissiadis Y, Poortmans PM, Offersen BV. A Delphi study and International Consensus Recommendations: The use of bolus in the setting of postmastectomy radiation therapy for early breast cancer. Radiother Oncol. 2021 Sep 24;164:115-121. doi: 10.1016/j.radonc.2021.09.012. Online ahead of print.
21. Redapi L, Rossi L, Marrazzo L, Penninkhof JJ, Pallotta S, Heijmen B. Comparison of volumetric modulated arc therapy and intensity-modulated radiotherapy for left-sided whole-breast irradiation using automated planning. Strahlenther Onkol. 2021 Aug 5. doi: 10.1007/s00066-021-01817-x. Online ahead of print.
22. Dahn HM, Boersma LJ, de Ruysscher D, Meattini I, Offersen BV, Pignol JP, Aristei C, Belkacemi Y, Benjamin D, Bese N, Coles CE, Franco P, Ho A, Hol S, Jagsi R, Kirby AM, Marrazzo L, Marta GN, Moran MS, Nichol AM, Nissen HD, Strnad V, Zissiadis YE, Poortmans P, Kaidar-Person O. The use of bolus in postmastectomy radiation therapy for breast cancer: A systematic review. Crit Rev Oncol Hematol. 2021 Jul;163:103391. doi: 10.1016/j.critrevonc.2021.103391. Epub 2021 Jun 5.
23. Calusi S, Arilli C, Mussi E, Puggelli L, Farnesi D, Casati M, Compagnucci A, Marrazzo L, Talamonti C, Zani M, Pallotta S. In phantom evaluation of targeting accuracy in MRI-based brain radiosurgery. Phys Med. 2021 May;85:158-164. doi: 10.1016/j.ejmp.2021.05.014. Epub 2021 May 17.
24. Piffer S, Casati M, Marrazzo L, Arilli C, Calusi S, Desideri I, Fusi F, Pallotta S, Talamonti C. Validation of a secondary dose check tool against Monte Carlo and analytical clinical dose calculation algorithms in VMAT. J Appl Clin Med Phys. 2021 Apr;22(4):52-62. doi: 10.1002/acm2.13209. Epub 2021 Mar 18.
25. Stick LB, Lorenzen EL, Yates ES, Anandadas C, Andersen K, Aristei C, Byrne O, Hol S, Jensen I, Kirby AM, Kirova YM, Marrazzo L, Matías-Pérez A, Nielsen MMB, Nissen HD, Oliveros S, Verhoeven K, Vikström J, Offersen BV. Selection criteria for early breast cancer patients in the DBCG proton trial - The randomised phase III trial strategy. Clin Transl Radiat Oncol. 2021 Feb 4;27:126-131. doi: 10.1016/j.ctro.2021.01.012. eCollection 2021 Mar.
26. Meattini I, Poortmans PM, Aznar MC, Becherini C, Bonzano E, Cardinale D, Lenihan DJ, Marrazzo L, Curigliano G, Livi L. Association of Breast Cancer Irradiation With Cardiac Toxic Effects: A Narrative Review. JAMA Oncol. 2021 Jun 1;7(6):924-932. doi: 10.1001/jamaoncol.2020.7468 
27. Casati M, Piffer S, Calusi S, Marrazzo L, Simontacchi G, Di Cataldo V, Greto D, Desideri I, Vernaleone M, Francolini G, Livi L, Pallotta S. Methodological approach to create an atlas using a commercial auto-contouring software. J Appl Clin Med Phys. 2020 Dec;21(12):219-230. doi: 10.1002/acm2.13093. Epub 2020 Nov 25.
28. Meattini I, Marrazzo L, Saieva C, Desideri I, Scotti V, Simontacchi G, Bonomo P, Greto D, Mangoni M, Scoccianti S, Lucidi S, Paoletti L, Fambrini M, Bernini M, Sanchez L, Orzalesi L, Nori J, Bianchi S, Pallotta S, Livi L. Accelerated Partial-Breast Irradiation Compared With Whole-Breast Irradiation for Early Breast Cancer: Long-Term Results of the Randomized Phase III APBI-IMRT-Florence Trial. J Clin Oncol. 2020 Dec 10;38(35):4175-4183. doi: 10.1200/JCO.20.00650. Epub 2020 Aug 24.
29. Meattini I, Poortmans PMP, Marrazzo L, Desideri I, Brain E, Hamaker M, et al. Exclusive endocrine therapy or partial breast irradiation for women aged ≥70  years with luminal A-like early stage breast cancer (NCT04134598 - EUROPA): Proof of concept of a randomized controlled trial comparing health related quality of life by patient reported outcome measures. J Geriatr Oncol. 2020 Jul 29:S1879-4068(20)30146-6. doi: 10.1016/j.jgo.2020.07.013. Online ahead of print.
30. Scoccianti S, Simontacchi G, Greto D, Perna M, Terziani F, Talamonti C, Teriaca MA, Caramia G, Lo Russo M, Olmetto E, Delli Paoli C, Grassi R, Carfora V, Saieva C, Bonomo P, Detti B, Mangoni M, Desideri I, Francolini G, Di Cataldo V, Marrazzo L, Pallotta S, Livi L. Dosimetric Predictors of Acute and Chronic Alopecia in Primary Brain Cancer Patients Treated With Volumetric Modulated Arc Therapy. Front Oncol. 2020 Apr 8;10:467. doi: 10.3389/fonc.2020.00467. eCollection 2020.
31. Marrazzo L, Arilli C, Pellegrini R, Bonomo P, Calusi S, Talamonti C, et al. Automated planning through robust templates and multicriterial optimization for lung VMAT SBRT of lung lesions. J Appl Clin Med Phys. 2020 Jun;21(6):114-120. doi: 10.1002/acm2.12872. Epub 2020 Apr 10.
32. Bonomo P, Talamonti C, Desideri I, Marrazzo L, Pezzulla D, Rampini A, et al. Analysis of skin dose distribution for the prediction of severe radiation dermatitis in head and neck squamous cell carcinoma patients treated with concurrent chemo-radiotherapy. Head Neck. 2020 Feb;42(2):244-253. doi: 10.1002/hed.25997. Epub 2019 Nov 4.
33. Pallotta S, Calusi S, Masi L, Talamonti C, Marrazzo L, Foggi L, et al. ADAM phantom to test 4D medical imaging and dose delivery devices. Phys Med Biol. IOP Publishing; 2019;64.
34. Calusi S, Labanca G, Zani M, Casati M, Marrazzo L, Noferini L, et al. A multiparametric method to assess the MIM deformable image registration algorithm. J Appl Clin Med Phys 2019:acm2.12564. doi:10.1002/acm2.12564 
35. Marrazzo L, Meattini I, Arilli C, Calusi S, Casati M, Talamonti C, et al. Auto-planning for VMAT accelerated partial breast irradiation. Radiother Oncol 2019;132:85–92. doi:10.1016/j.radonc.2018.11.006.
36. Zani M, Marrazzo L, Calusi S, Talamonti C, Scoccianti S, Greto D, et al. TomoTherapy treatments of multiple brain lesions: an in-phantom accuracy evaluation. Phys Med Biol 2018:0–22. doi:10.1088/1361-6560/aaf977.
37. Becherini C, Meattini I, Livi L, Garlatti P, Desideri I, Scotti V, Orzalesi L, Sanchez LJ, Bernini M, Casella D, Nesi S, Nori J, Bianchi S, Pallotta S, Marrazzo L. External accelerated partial breast irradiation for ductal carcinoma in situ: long-term follow-up from a phase 3 randomized trial. Tumori J 2018:030089161881127. doi:10.1177/0300891618811278.
38. Meattini I, Poortmans P, Livi L, Kaidar Person O, Pallotta S, Becherini C, et al. Partial breast irradiation for ductal carcinoma in situ: The Goldilocks principle? Breast J 2018;24:1118–9. doi:10.1111/tbj.13143.
39. Heijmen B, Voet P, Fransen D, Penninkhof J, Milder M, Akhiat H, et al. Fully automated, multi-criterial planning for Volumetric Modulated Arc Therapy – An international multi-center validation for prostate cancer. Radiother Oncol 2018. doi:10.1016/j.radonc.2018.06.023.
40. Bonomo P, Desideri I, Loi M, Mangoni M, Sottili M, Marrazzo L, et al. Anti PD-L1 DUrvalumab combined with Cetuximab and RadiOtherapy in locally advanced squamous cell carcinoma of the head and neck: A phase I/II study (DUCRO). Clin Transl Radiat Oncol 2018;9:42–7. doi:10.1016/j.ctro.2018.01.005.
41. Meattini I, Livi L, Pallotta S, Marrazzo L. Partial breast irradiation: The time is there! Breast 2018;38:98–100. doi:10.1016/j.breast.2017.12.014.
42. Marrazzo L, Arilli C, Pasler M, Kusters M, Canters R, Fedeli L, et al. Real-time beam monitoring for error detection in IMRT plans and impact on dose-volume histograms: A multi-center study. Strahlentherapie Und Onkol 2017;194:243–54. doi:10.1007/s00066-017-1245-3.
43. Calusi S, Noferini L, Marrazzo L, Casati M, Arilli C, Compagnucci A, et al. γTools: A modular multifunction phantom for quality assurance in GammaKnife treatments. Phys Medica 2017;43:34–42. doi:10.1016/j.ejmp.2017.10.010.
44. Scoccianti S, Krengli M, Marrazzo L, Magrini SM, Detti B, Fusco V, et al. Hypofractionated radiotherapy with simultaneous integrated boost (SIB) plus temozolomide in good prognosis patients with glioblastoma: a multicenter phase II study by the Brain Study Group of the Italian Association of Radiation Oncology (AIRO). Radiol Med 2017;123:48–62. doi:10.1007/s11547-017-0806-y.
45. Pallotta S, Calusi S, Foggi L, Lisci R, Masi L, Marrazzo L, et al. ADAM: A breathing phantom for lung SBRT quality assurance. Phys Medica 2017. doi:10.1016/j.ejmp.2017.07.004.
46. Pasler M, Michel K, Marrazzo L, Obenland M, Pallotta S, Björnsgard M, et al. Error detection capability of a novel transmission detector: A validation study for online VMAT monitoring. Phys Med Biol 2017;62:7440–50. doi:10.1088/1361-6560/aa7dc7.
47. Meattini I, Saieva C, Miccinesi G, Desideri I, Francolini G, Scotti V, et al. Accelerated partial breast irradiation using intensity modulated radiotherapy versus whole breast irradiation: Health-related quality of life final analysis from the Florence phase 3 trial. Eur J Cancer 2017;76:17–26. doi:10.1016/j.ejca.2017.01.023.
48. Schwarz M, Cattaneo GM, Marrazzo L. Geometrical and dosimetrical uncertainties in hypofractionated radiotherapy of the lung: A review. Phys Medica 2017;36:126–39. doi:10.1016/j.ejmp.2017.02.011.
49. Greto D, Pallotta S, Masi L, Talamonti C, Marrazzo L, Doro R, et al. A dosimetric comparison between CyberKnife and tomotherapy treatment plans for single brain metastasis. Radiol Medica 2017;122:392–7. doi:10.1007/s11547-017-0735-9.
50. Marrazzo L, Zani M, Pallotta S, Arilli C, Casati M, Compagnucci A, et al. GafChromic®EBT3 films for patient specific IMRT QA using a multichannel approach. Phys Medica 2015;31:1035–42. doi:10.1016/j.ejmp.2015.08.010.
51. Meattini I, Saieva C, Marrazzo L, Di Brina L, Pallotta S, Mangoni M, et al. Accelerated partial breast irradiation using intensity-modulated radiotherapy technique compared to whole breast irradiation for patients aged 70 years or older: subgroup analysis from a randomized phase 3 trial. Breast Cancer Res Treat 2015;153:539–47. doi:10.1007/s10549-015-3565-2.
52. Pallotta S, Vanzi E, Simontacchi G, Marrazzo L, Ceroti M, Paiar F, et al. Surface imaging, portal imaging, and skin marker set-up vs. CBCT for radiotherapy of the thorax and pelvis. Strahlentherapie Und Onkol 2015;191:726–33. doi:10.1007/s00066-015-0861-z.
53. Meattini I, Marrazzo L, Zani M, Paiar F, Pallotta S, Simontacchi G, et al. Four-dimensional computed tomography in accelerated partial breast irradiation planning: single series from a phase III trial. Radiol Medica 2015;120:1078–82. doi:10.1007/s11547-015-0541-1.
54. Livi L, Meattini I, Marrazzo L, Simontacchi G, Pallotta S, Saieva C, et al. Accelerated partial breast irradiation using intensity-modulated radiotherapy versus whole breast irradiation: 5-year survival analysis of a phase 3 randomised controlled trial. Eur J Cancer 2015;51:451–63. doi:10.1016/j.ejca.2014.12.013.
55. Marrazzo L, Zani M, Pallotta S, Greto D, Scoccianti S, Talamonti C, et al. Comparison of stereotactic plans for brain tumors with two different multileaf collimating systems. J Appl Clin Med Phys 2014;15:27–37. doi:10.1120/jacmp.v15i1.4100.
56. Scotti V, Marrazzo L, Saieva C, Agresti B, Meattini I, Desideri I, et al. Impact of a breathing-control system on target margins and normal-tissue sparing in the treatment of lung cancer: Experience at the radiotherapy unit of Florence University. Radiol Medica 2014;119:13–9. doi:10.1007/s11547-013-0307-6.
57. Franceschini D, Paiar F, Meattini I, Agresti B, Pasquetti EM, Greto D, et al. Simultaneous integrated boost-intensity-modulated radiotherapy in head and neck cancer. Laryngoscope 2013;123:97–103. doi:10.1002/lary.24257.
58. Bonomo P, Livi L, Rampini A, Meattini I, Agresti B, Simontacchi G, et al. Radioterapia stereotassica extracranica per metastasi cardiache e paracardiache: esperienza dell’Università di Firenze. Radiol Medica 2013;118:1055–65. doi:10.1007/s11547-013-0932-0.
59. Meattini I, Livi L, Franceschini D, Saieva C, Meacci F, Marrazzo L, et al. Role of radiotherapy boost in women with ductal carcinoma in situ: A single-center experience in a series of 389 patients. Eur J Surg Oncol 2013;39:613–8. doi:10.1016/j.ejso.2013.03.002.
60. Livi L, Meattini I, Franceschini D, Saieva C, Meacci F, Marrazzo L, et al. Radiotherapy boost dose-escalation for invasive breast cancer after breast-conserving surgery: 2093 Patients treated with a prospective margin-directed policy. Radiother Oncol 2013;108:273–8. doi:10.1016/j.radonc.2013.02.009.
61. Scoccianti S., Agresti B., Simontacchi G., Detti B., Cipressi S., Iannalfi A., Marrazzo L., Mangoni M., Paiar F., Livi L., Biti G. From a waiting list to a priority list: a computerized model for an easy-to-manage and automatically updated priority list in the booking of patients waiting for radiotherapy. Tumori, 98(6), 728-35, 2012.
62. Pallotta S, Simontacchi G, Marrazzo L, Ceroti M, Paiar F, Biti G, et al. Accuracy of a 3D laser/camera surface imaging system for setup verification of the pelvic and thoracic regions in radiotherapy treatments. Med Phys 2013;40. doi:10.1118/1.4769428.
63. Marrazzo L, Pallotta S, Kłosowski M, Czopyk, Bucciolini M, Olko P, et al. Clinical tests of large area thermoluminescent detectors under radiotherapy beams. Radiat Meas 2013;51–52:25–30. doi:10.1016/j.radmeas.2013.02.006.
64. Meattini I, Livi L, Saieva C, Franceschini D, Marrazzo L, Greto D, et al. Prognostic factors and clinical features in patients with leptominengeal metastases from breast cancer: a single center experience. J Chemother 2012;24:279–84. doi:10.1179/1973947812Y.0000000034.
65. Pallotta S, Marrazzo L, Ceroti M, Silli P, Bucciolini M. A phantom evaluation of Sentinel, a commercial laser/camera surface imaging system for patient setup verification in radiotherapy. Med Phys 2012;39:706–12. doi:10.1118/1.3675973.
66. Tonoli S, Vitali P, Scotti V, Bertoni F, Spiazzi L, Ghedi B, et al. Adjuvant radiotherapy after extrapleural pneumonectomy for mesothelioma. Prospective analysis of a multi-institutional series. Radiother Oncol 2011;101:311–5. doi:10.1016/j.radonc.2011.09.025.
67. Talamonti C, Bruzzi M, Marrazzo L, Menichelli D, Scaringella M, Bucciolini M. Bidimensional silicon dosimeter: Development and characterization. Nucl Instruments Methods Phys Res Sect A Accel Spectrometers, Detect Assoc Equip 2011;658:84–9. doi:10.1016/j.nima.2011.05.044.
68. Livi L, Meattini I, Scotti V, Saieva C, Simontacchi G, Marrazzo L, et al. Radio-chemioterapia concomitante con regimi a base dantracicline nel trattamento adiuvante del carcinoma mammario: Esperienza di un singolo centro. Radiol Medica 2011;116:1050–8. doi:10.1007/s11547-011-0652-2.
69. Scotti V, Meattini I, Saieva C, Agresti B, de Luca Cardillo C, Bastiani P, et al. Post-operative radiotherapy in N2 non-small cell lung cancer: A retrospective analysis of 175 patients. Radiother Oncol 2010;96:84–8. doi:10.1016/j.radonc.2010.05.010.
70. Livi L, Scotti V, Saieva C, Meattini I, Detti B, Simontacchi G, et al. Outcome After Conservative Surgery and Breast Irradiation in 5,717 Patients With Breast Cancer: Implications for Supraclavicular Nodal Irradiation. Int J Radiat Oncol Biol Phys 2010;76:978–83. doi:10.1016/j.ijrobp.2009.03.001. 
71. Livi L, Buonamici FB, Simontacchi G, Scotti V, Fambrini M, Compagnucci A, et al. Accelerated Partial Breast Irradiation With IMRT: New Technical Approach and Interim Analysis of Acute Toxicity in a Phase III Randomized Clinical Trial. Int J Radiat Oncol Biol Phys 2010;77:509–15. doi:10.1016/j.ijrobp.2009.04.070.
72. Livi L, Meattini I, Saieva C, Borghesi S, Scotti V, Petrucci A, et al. The impact of young age on breast cancer outcome. Eur J Surg Oncol 2010;36:639–45. doi:10.1016/j.ejso.2010.05.016.
73. Meattini I, Livi L, Saieva C, Marrazzo L, Rampini A, Iermano C, et al. Breast Cancer Following Hodgkin’s Disease: The Experience of the University of Florence. Breast J 2010;16:290–6. doi:10.1111/j.1524-4741.2010.00904.x.
74. Talamonti C, Reggioli V, Bruzzi M, Bucciolini M, Civinini C, Marrazzo L, et al. Proton radiography for clinical applications. Nucl Instruments Methods Phys Res Sect A Accel Spectrometers, Detect Assoc Equip 2010;612:571–5. doi:10.1016/j.nima.2009.08.040.
75. Sipala V, Bruzzi M, Bucciolini M, Candiano G, Capineri L, P. Cirrone GA, et al. A proton imaging device: Design and status of realization. Nucl Instruments Methods Phys Res Sect A Accel Spectrometers, Detect Assoc Equip 2010;612:566–70. doi:10.1016/j.nima.2009.08.029.
76. Civinini C, Brianzi M, Bruzzi M, Bucciolini M, Candiano G, Capineri L, et al. Towards a proton imaging system. Nucl Instruments Methods Phys Res Sect A Accel Spectrometers, Detect Assoc Equip 2010;623:588–90. doi:10.1016/j.nima.2010.03.079.
77. Menichelli D, Bruzzi M, Bucciolini M, Candiano G, Cirrone G, Capineri L, et al. Characterization of a silicon strip detector and a YaG: Ce calorimeter for a proton computed radiography apparatus. Nucl Sci IEEE Trans 2010;57:8–16.
78. Livi L, Borghesi S, Saieva C, Meattini I, Rampini A, Petrucci A, et al. Radiotherapy Timing in 4,820 Patients With Breast Cancer: University of Florence Experience. Int J Radiat Oncol Biol Phys 2009;73:365–9. doi:10.1016/j.ijrobp.2008.04.066.
79. Sipala V, Bruzzi M, Bucciolini M, Candiano G, Capineri L, Cirrone GAP, et al. First Results and Realization Status of a Proton Computed Radiography Device. Nucl Phys B - Proc Suppl 2009;197:39–42. doi:10.1016/j.nuclphysbps.2009.10.030.
80. Talamonti C, Bucciolini M, Marrazzo L, Menichelli D, Bruzzi M, Cirrone GAP, et al. Dosimetric characterization with 62 MeV protons of a silicon-segmented detector for 2D dose verifications in radiotherapy. Nucl Instruments Methods Phys Res Sect A Accel Spectrometers, Detect Assoc Equip 2008;596:126–30. doi:10.1016/j.nima.2008.07.134.
81. Banci Buonamici F, Compagnucci A, Marrazzo L, Russo S, Bucciolini M. An intercomparison between film dosimetry and diode matrix for IMRT quality assurance. Med Phys 2007;34:1372–9. doi:10.1118/1.2713426.
82. Pallotta S, Marrazzo L, Bucciolini M. Design and implementation of a water phantom for IMRT, arc therapy, and tomotherapy dose distribution measurements. Med Phys 2007;34:3724–31. doi:10.1118/1.2776249.
83. Talamonti C, Bruzzi M, Bucciolini M, Marrazzo L, Menichelli D. Preliminary dosimetric characterization of a silicon segmented detector for 2D dose verifications in radiotherapy. Nucl Instruments Methods Phys Res Sect A Accel Spectrometers, Detect Assoc Equip 2007;583:114–8. doi:10.1016/j.nima.2007.08.225.
84. Menichelli D, Bruzzi M, Bucciolini M, Talamonti C, Casati M, Marrazzo L, et al. Design and development of a silicon-segmented detector for 2D dose measurements in radiotherapy. Nucl Instruments Methods Phys Res Sect A Accel Spectrometers, Detect Assoc Equip 2007;583:109–13. doi:10.1016/j.nima.2007.08.209.

Livia Marrazzo graduated with honors in Physics from the University of Naples "Federico II" in 2003.
In 2008, she obtained, with honors, the Specialization Diploma in Medical Physics from the University of Florence.
She is currently a Medical Physicist at the Careggi University Hospital in Florence and a Tenure-Track Researcher (RTDB) at the Department of Experimental and Clinical Biomedical Sciences of the University of Florence.
Her clinical and research activities focus on radiotherapy, with particular emphasis on advanced and automated treatment planning techniques, breast cancer management, and Radiotherapy Quality Assurance (RTQA) in multicenter clinical trials.

Curriculum vitae et studiorum

Livia Marrazzo

Personal information

Place of birth: Torre del Greco, Napoli (Italia)

Nationality: Italian

Email: livia.marrazzo@unifi.it

Education

2008: Medical Physics certification, University of Florence (Italy).

2004: MSc in Radiation Biology, University College London (UK).

2003: MSc in Physics, University of Naples (Italy).

Work experience

Current position: Assistant Professor at the Department of Experimental and Clinical Biomedical Sciences, University of Florence, Italy (since October 2022).

Medical Physicist, Azienda Ospedaliero-Universitaria Careggi, Firenze (since January 2009). Working at the Medical Physics Unit, Radiotherapy, of the University Hospital Careggi.

Main skills:

-       Photon and electron beam dosimetry for clinical applications;

-       Quality Assurance on linear accelerators, brachytherapy sources, Tomotherapy, imaging devices (CT scanners, portal imaging devices, Cone Beam kV CT, laser-camera based surface acquisition systems);

-       Treatment planning with 3DCRT, IMRT, VMAT techniques;

-       Treatment planning and quality assurance in Gamma Knife;

-       Commissioning of radiotherapy linear accelerators;

-       Commissioning and use of several treatment planning systems for 3DCRT, stereotactic RT, intensity modulated RT and intensity modulated arc therapy;

-       Automated planning, development and validation;

-       Breast cancer treatment;

-       Patient-based dosimetric verification of IMRT treatments with different detectors;

-       Dosimetric characterization of new developed detectors;

-       Use of Record & Verify software;

-       Use of PACS systems;

-       Information systems support.

March 2005 - December 2008: Scholarship on “Physical Methods and Procedures for High Conformity Radiotherapy Treatments”, University of Florence.

The activity mainly concerned the development and the dosimetric characterization of a 2D silicon detector for patient-based dose verification in radiotherapy. The work was part of the MAESTRO (Methods and Advanced Equipment for Simulation and Treatment in Radio Oncology) European Project. The work also included the characterization of radiochromic films (GAFCHROMIC EBT) and the design and manufacture of a water phantom for dosimetric verification in radiotherapy.

The research activity also regarded the PRIN-PRIMA project ("PRoton IMAging and conformal radiotherapy dosimetry by segmented silicon detectors"), aiming to the design and manufacture of a proton Computed Tomography (pCT) apparatus for patient positioning verification in Proton Therapy. I have been involved in the Monte Carlo simulation of the experimental setup and in the analysis of the experimental data acquired at Loma Linda Medical Center.

Teaching appointments

Since 2014: Habilitation (’abilitazione’) for the position of Associate Professor in Physics (FIS/07).

Since 2022: Coordinator of the Basic Physics Course in the first-degree master for Medical Radiology Techniques for Imaging and Radiotherapy, University of Florence (2 university credits)

Since 2022: Teaching in the Applied Physics Course in the master for Dentistry and Dental Prosthesis, University of Florence (1 university credit)

Since 2022: Teaching in the Physics, Statistics and Computer Science Course in the master for Neurophysiopathology Techniques, Biomedical Laboratory Techniques and Dietistics, University of Florence (2 university credits)

2009 - 2022: Contract professor in “Mathematics, Physics, Statistic and Informatics”, in the first-degree course for “Radiographer for Imaging and Radiotherapy”, University of Florence.

Since 2009: Teaching in the Postgraduate School in Medical Physics in the Course on Quality Assurance on Linear Accelerators and Patient-based Dosimetric Verification.

2015 - 2019: Teaching in the Postgraduate Master in Radiotherapy for Dosimetrists in the Course in Oncologic Radiotherapy: technological, therapeutic and dosimetric aspects, University of Florence.

Other professional appointments

19-20^th of February 2024: Scientific Coordinator of the Course on “From Diagnostics to Radiotherapy of breast cancer: state of the art and new perspectives” (Scuola Superiore di Fisica in Medicina Piero Caldirola) held in Florence.

2023: Reviewer of abstracts submitted to the AIFM congress

2023-2024: member of the Scientific Advisory Group for Physics of the ESTRO 2024 Congress

2022-2023: member of the Scientific Advisory Group for Physics of the ESTRO 2023 Congress

Since 2020: Associate Editor for “European Journal of Medical Physics”

21^st August 2020 -20^th September 2021: member as Reviewer Editor of the Editorial Board of “Frontiers in Oncology”

23^rd of September 2019: Scientific Coordinator of the Course on “Dose calculation in external beam radiotherapy” (Scuola Superiore di Fisica in Medicina Piero Caldirola) held in Rome.

2017–2018: Member of the Scientific Committee for Physics in Radiotherapy, 2018 AIFM (Italian Association of Medical Physics) congress

Since 2016: Reviewer of abstracts submitted to the ESTRO congress

Since 2010: Reviewer of manuscripts submitted to many indexed journals such as ’European Journal of Medical Physics’, ’Radiation Measurements’, ’Practical Radiation Oncology’, ’Radiotherapy and Oncology’. Selected as ’Outstanding reviewer’ in 2015 and 2017 for the ’European Journal of Medical Physics’ and in 2016 for ’Radiation Measurements’.

Supervision of students

2023 - University of Florence - Co-supervisor of a specialization thesis in Medical Physics on “DOSIMETRIC AND CLINICAL EVALUATION OF A NEW FULLY AUTOMATED PLANNING SYSTEM FOR WHOLE BREAST IRRADIATION”

2022 – University of Milan - Referee of a specialization thesis in Medical Physics on “COMPREHENSIVE DOSIMETRIC AND CLINICAL EVALUATION OF LEXICOGRAPHIC OPTIMIZATION-BASED PLANNING FOR CERVICAL CANCER”

2012 - University of Florence - Supervisor of a first-degree thesis for Radiographer for Imaging and Radiotherapy on “OPTIMIZATION OF SETUP AND SHIELDING IN TOTAL SKIN ELECTRON THERAPY”

2010 - University of Florence - Supervisor of a first-degree thesis for Radiographer for Imaging and Radiotherapy on “COMPARISON OF TWO MLC DEVICES FOR SRS”

Invited talks, seminars, lectures, and oral communications

1. 7-11 October 2024 – Trieste, Italy – Joint ICTP-IAEA Workshop on Radiation Protection in Image-Guided Radiotherapy (IGRT) – Invited talk – Discussion on Radiological protection for adaptive radiotherapy
2. 12-14 June 2024 – Dijon, France – 62ème Journées Scientifiques, SFPM -Invited talk – Automated planning in clinical practice
3. 12-16 May 2023 – Wien – ESTRO 2023 – Invited talk – Will automation of radiotherapy tasks solve more problems than it causes? Planning automation
4. 8-11 June 2023 – 12° Congresso Nazionale AIFM – Invited talk – Debate on present and future of radiation therapy automated planning systems. Optimization Based techniques are advantageous if compared to Knowledge Based techniques
5. 8-11 June 2023 – 12° Congresso Nazionale AIFM – Oral Communication – Rotational Total Skin Electron Therapy with an in-house built flattening filter
6. 03 February 2023 – Virtual – 14th annual COMP Winter School– Invited talk – Automation in Radiation Therapy Treatment Planning
7. 02 December 2022- AIRO Webinar on Primary and Secondary Liver Neoplasms: contouring and implications in clinical practice - Invited talk – Radiation Therapy Treatment Planning at linac
8. 06-10 May 2022 – Copenhagen – ESTRO 2022 – Invited talk – Keeping automatic planning up to date: How to incorporate changes to dose prescription, technique, and OAR constraints
9. 06-10 May 2022 – Copenhagen – ESTRO 2022 – Oral Communication – Fully automated VMAT technique for radiation therapy of high-risk breast cancer
10. 16-19 June 2021 – 3^rd European Congress of Medical Physics – 11° Congresso Nazionale AIFM – Oral Communication – Feasibility, robustness and dosimetric accuracy of the treatment of face and scalp with helical Tomotherapy
11. 16-19 June 2021 – 3^rd European Congress of Medical Physics – 11° Congresso Nazionale AIFM – Oral Communication – A semi-automatic planning technique for whole breast irradiation with tangential IMRT fields
12. 18 June 2020 – Webinar on Automated Planning organized by TEMA Sinergie – Invited talk – Pinnacle3 AutoPlanning in the treatment of the breast
13. December 2019 – Singapore – ESTRO meets ASIA Congress – Invited talk – Automated planning in clinical practice
14. 31 May 2019 – Florence – Course organized by Careggi University Hospital on “Evaluation of the lens dose following EURATOM directive 2013/59” – Invited talk – Lens dose in radiotherapy
15. October 2018 – Bologna – Elekta user meeting – Invited talk – Automated planning with Monaco TPS
16. October 2018 – Firenze – AIFM course on Stereotactic Body Radiation Therapy: from physics to clinic – Invited talk – Autoplanning in SBRT
17. April 2018 – Bari – X AIFM Congress – Oral communication – Automated planning for VMAT APBI
18. June 2017 – Verona – Corso Caldirola “4D techniques and adaptive radiation therapy” – Invited talk – 4D radiotherapy of the breast
19. May 2017 – Wien – ESTRO36 – Invited talk – Target coverage and dose to organs at risk using different techniques of APBI (EBI, IORT, BT)
20. April 2016 – Torino – ESTRO 35 oral communication – Delivery errors detectability with IQM, a system for real-time monitoring of radiotherapy treatments
21. February 2016 – Perugia – IX AIFM Congress – Oral communication – Dose verification of VMAT hypofractionated lung treatments in moving phantom
22. October 2015 – Florence – Workshop: Image Guided Radiation Therapy (IGRT) and respiratory gating with optical systems
23. March 2014 – Florence – Workshop: "Ray in the Sunrise: Adaptive Radiotherapy” – Invited talk – From gamma to DVH: validation and first clinical applications of 3DVH
24. November 2013 – Torino – VIII AIFM Congress – Oral communication – Patient based dosimetric verification: from gamma to DVH
25. March 2013 – Firenze – ESTRO course on Dose Modelling and Verification for External Beam Radiotherapy – Invited talk – Experience of Florence Medical Physics on patient-based dose verification, with different types of detectors (2D and 3D)
26. November 2012 – Firenze – Workshop on special techniques in radiotherapy – Invited talk – Dosimetric verification for special techniques
27. September 2009 – Reggio Emilia – VI AIFM Congress – Oral communication – Optimization of the acquisition parameters of a kV Cone-Beam CT

Book chapters

Breast cancer Radiation Therapy. A Practical Guide for Technical Applications (editors Orit Kaidar-Person, Icro Meattini, Philip Poortmans), 2022, Springer International Publishing.

Stomach, Duodenum, Liver and Central hepatobiliary tract - Modelling Radiotherapy Side Effects: Practical Applications for Planning Optimisation(editors Tiziana Rancati and Claudio Fiorino), ISBN 9781138198098, 2019, CRC Press.

Publications

1. Marrazzo L, Chilà D, Vanore I, Pellegrini R, Voet P, Di Cataldo V, Meattini I, Zani M, Arilli C, Calusi S, Casati M, Compagnucci A, Talamonti C, Livi L, Pallotta S, Planning Automation for Treatment Techniques Comparison and Robustness Analysis: Tangential Intensity Modulated Radiation Therapy and Volumetric Modulated Arc Therapy for Whole Breast Irradiation, Advances in Radiation Oncology, 2025, https://doi.org/10.1016/j.adro.2025.101719.
2. Meattini I, De Santis MC, Visani L, Scorsetti M, Fozza A, Meduri B, De Rose F, Bonzano E, Prisco A, Masiello V, La Rocca E, Spoto R, Becherini C, Blandino G, Moscetti L, Colciago RR, Audisio RA, Brain E, Caini S, Hamaker M, Kaidar-Person O, Lambertini M, Marrazzo L, Saieva C, Spanic T, Strnad V, Wheelwright S, Poortmans PMP, Livi L; EUROPA Trial Investigators. Single-modality endocrine therapy versus radiotherapy after breast-conserving surgery in women aged 70 years and older with luminal A-like early breast cancer (EUROPA): a preplanned interim analysis of a phase 3, non-inferiority, randomised trial. Lancet Oncol. 2024 Dec 11:S1470-2045(24)00661-2. doi: 10.1016/S1470-2045(24)00661-2. Epub ahead of print. PMID: 39675376.
3. Marrazzo L, Meattini I, Becherini C, Salvestrini V, Visani L, Barletta G, Saieva C, Del Bene MR, Pilato G, Desideri I, Arilli C, Paoletti L, Russo S, Scoccianti S, Martella F, Francolini G, Simontacchi G, Nori Cucchiari J, Pellegrini R, Livi L, Pallotta S., Subclinical cardiac damage monitoring in breast cancer patients treated with an anthracycline-based chemotherapy receiving left-sided breast radiation therapy: subgroup analysis from a phase 3 trial. Radiol Med. 2024 Oct 22. doi: 10.1007/s11547-024-01897-6. Online ahead of print. PMID: 39436588
4. Lastrucci A, Marrazzo L, Meattini I, Simontacchi G, Wandael Y, Talamonti C, Pallotta S, Ricci R, Livi L. Advancing patient setup: A comprehensive scoping review of tattoo-less techniques in radiation therapy. Crit Rev Oncol Hematol. 2024 Sep 20;204:104518. doi: 10.1016/j.critrevonc.2024.104518. Online ahead of print. PMID: 39299409 Review.
5. Lastrucci A, Morelli I, Votta C, Maran I, Iosca N, Monaco IP, Salvestrini V, Desideri I, Marrazzo L, Wandael Y, Cornacchione P, Pallotta S, Giansanti D, Ricci R, Livi L, Bonomo P. Open-Face Masks in Radiotherapy: Enhancing Therapeutic Strategies for Head and Neck and Brain Cancer Patients-A Comprehensive Scoping Review. Cancers (Basel). 2024 Aug 21;16(16):2899. doi: 10.3390/cancers16162899. PMID: 39199669 Free PMC article. Review.
6. Lastrucci A, Esposito M, Serventi E, Marrazzo L, Francolini G, Simontacchi G, Wandael Y, Barra A, Pallotta S, Ricci R, Livi L. Enhancing patient safety in radiotherapy: Implementation of a customized electronic checklist for radiation therapists. Tech Innov Patient Support Radiat Oncol. 2024 May 28;31:100255. doi: 10.1016/j.tipsro.2024.100255. eCollection 2024 Sep. PMID: 38882236 Free PMC article.
7. Piffer S, Greto D, Ubaldi L, Mortilla M, Ciccarone A, Desideri I, Genitori L, Livi L, Marrazzo L, Pallotta S, Retico A, Sardi I, Talamonti C. Radiomic- and dosiomic-based clustering development for radio-induced neurotoxicity in pediatric medulloblastoma. Childs Nerv Syst. 2024 Aug;40(8):2301-2310. doi: 10.1007/s00381-024-06416-6. Epub 2024 Apr 20. PMID: 38642113 Free PMC article.
8. Marrazzo L, Redapi L, Pellegrini R, Voet P, Meattini I, Arilli C, Calusi S, Casati M, Chilà D, Compagnucci A, Talamonti C, Zani M, Livi L, Pallotta S. Fully automated volumetric modulated arc therapy technique for radiation therapy of locally advanced breast cancer. Radiat Oncol. 2023 Oct 30;18(1):176. doi: 10.1186/s13014-023-02364-8. PMID: 37904150 Free PMC article.
9. Marrazzo L, Meattini I, Simontacchi G, Livi L, Pallotta S. Updates on the APBI-IMRT-Florence Trial (NCT02104895) Technique: From the Intensity Modulated Radiation Therapy Trial to the Volumetric Modulated Arc Therapy Clinical Practice. Pract Radiat Oncol. 2023 Jan-Feb;13(1):e28-e34. doi: 10.1016/j.prro.2022.05.010. Epub 2022 Jun 2. PMID: 35659597
10. Pallotta S, Calusi S, Marrazzo L, Talamonti C, Russo S, Esposito M, Fiandra C, Giglioli FR, Pimpinella M, De Coste V, Bruschi A, Barbiero S, Mancosu P, Stasi M, Lisci R. End-to-end test for lung SBRT: An Italian multicentric pilot experience. Phys Med. 2022 Dec;104:129-135. doi: 10.1016/j.ejmp.2022.11.004. Epub 2022 Nov 16. PMID: 36401941
11. Matsui JK, Perlow HK, Facer BD, McCalla A, Marrazzo L, Detti B, Scorsetti M, Clerici E, Scoccianti S, Navarria P, Trifiletti DM, Gondi V, Bovi J, Huang J, Brown PD, Palmer JD. Radiotherapy for elderly patients with glioblastoma: an assessment of hypofractionation and modern treatment techniques. Chin Clin Oncol. 2022 Oct;11(5):38. doi: 10.21037/cco-22-76. PMID: 36336897 Free article.
12. Perlow HK, Prasad RN, Yang M, Klamer B, Matsui J, Marrazzo L, Detti B, Scorsetti M, Clerici E, Arnett A, Beyer S, Ammirati M, Chakravarti A, Raval RR, Brown PD, Navarria P, Scoccianti S, Grecula JC, Palmer JD. Accelerated hypofractionated radiation for elderly or frail patients with a newly diagnosed glioblastoma: A pooled analysis of patient-level data from 4 prospective trials. Cancer. 2022 Jun 15;128(12):2367-2374. doi: 10.1002/cncr.34192. Epub 2022 Mar 22. PMID: 35315512
13. Marrazzo L, Redapi L, Zani M, Calusi S, Meattini I, Arilli C, Casati M, Compagnucci A, Talamonti C, Raspanti D, Pertutti S, Di Cataldo V, Livi L, Pallotta S. A semi-automatic planning technique for whole breast irradiation with tangential IMRT fields. Phys Med. 2022 Jun;98:122-130. doi: 10.1016/j.ejmp.2022.05.001. Epub 2022 May 7. PMID: 35537327
14. Casati M, Piffer S, Calusi S, Marrazzo L, Simontacchi G, Di Cataldo V, Greto D, Desideri I, Vernaleone M, Francolini G, Livi L, Pallotta S. Clinical validation of an automatic atlas-based segmentation tool for male pelvis CT images. Appl Clin Med Phys. 2022 Jan 22:e13507. doi: 10.1002/acm2.13507. Online ahead of print.
15. Meattini I, Becherini C, Boersma L, Kaidar-Person O, Marta GN, Montero A, Offersen BV, Aznar MC, Belka C, Brunt AM, Dicuonzo S, Franco P, Krause M, MacKenzie M, Marinko T, Marrazzo L, Ratosa I, Scholten A, Senkus E, Stobart H, Poortmans P, Coles CE. European Society for Radiotherapy and Oncology Advisory Committee in Radiation Oncology Practice consensus recommendations on patient selection and dose and fractionation for external beam radiotherapy in early breast cancer. Lancet Oncol. 2022 Jan;23(1):e21-e31. doi: 10.1016/S1470-2045(21)00539-8.
16. Pallotta S, Marrazzo L, Calusi S, Castriconi R, Fiorino C, Loi G, Fiandra C., Implementation of automatic plan optimization in Italy: Status and perspectives. Phys Med. 2021 Dec 4;92:86-94. doi: 10.1016/j.ejmp.2021.11.013.
17. Perlow HK, Yang M, Klamer B, Marrazzo L, Detti B, Scorsetti M, Clerici E, Arnett ALH, Beyer S, Ammirati M, Grecula JC, Chakravarti A, Raval R, Navarria P, Scoccianti S, Palmer JD. Dose-Escalated Accelerated Hypofractionation for Patients with a Newly Diagnosed Glioblastoma: A Pooled International Study. Int J Radiat Oncol Biol Phys. 2021 Nov 1;111(3S):S26. doi: 10.1016/j.ijrobp.2021.07.087.
18. Esposito M, Marrazzo L, Vanzi E, Russo S, Pallotta S, Talamonti C. A Validation Method for EPID In Vivo Dosimetry Algorithms. Applied Sciences. 2021; 11(22):10715. https://doi.org/10.3390/app112210715.
19. Arilli C, Zani M, Marrazzo L, Scoccianti S, Casati M, Compagnucci A, Talamonti C, Livi L, Pallotta S. Automatic VMAT technique to treat glioblastoma: A two years' experience. Phys Med. 2021 Oct;90:115-122. doi: 10.1016/j.ejmp.2021.09.015. Epub 2021 Oct 6.
20. Kaidar-Person O, Dahn HM, Nichol AM, Boersma LJ, de Ruysscher D, Meattini I, Pignol JP, Aristei C, Belkacemi Y, Benjamin D, Bese N, Coles CE, Franco P, Ho AY, Hol S, Jagsi R, Kirby AM, Marrazzo L, Marta GN, Moran MS, Nissen HD, Strnad V, Zissiadis Y, Poortmans PM, Offersen BV. A Delphi study and International Consensus Recommendations: The use of bolus in the setting of postmastectomy radiation therapy for early breast cancer. Radiother Oncol. 2021 Sep 24;164:115-121. doi: 10.1016/j.radonc.2021.09.012. Online ahead of print.
21. Redapi L, Rossi L, Marrazzo L, Penninkhof JJ, Pallotta S, Heijmen B. Comparison of volumetric modulated arc therapy and intensity-modulated radiotherapy for left-sided whole-breast irradiation using automated planning. Strahlenther Onkol. 2021 Aug 5. doi: 10.1007/s00066-021-01817-x. Online ahead of print.
22. Dahn HM, Boersma LJ, de Ruysscher D, Meattini I, Offersen BV, Pignol JP, Aristei C, Belkacemi Y, Benjamin D, Bese N, Coles CE, Franco P, Ho A, Hol S, Jagsi R, Kirby AM, Marrazzo L, Marta GN, Moran MS, Nichol AM, Nissen HD, Strnad V, Zissiadis YE, Poortmans P, Kaidar-Person O. The use of bolus in postmastectomy radiation therapy for breast cancer: A systematic review. Crit Rev Oncol Hematol. 2021 Jul;163:103391. doi: 10.1016/j.critrevonc.2021.103391. Epub 2021 Jun 5.
23. Calusi S, Arilli C, Mussi E, Puggelli L, Farnesi D, Casati M, Compagnucci A, Marrazzo L, Talamonti C, Zani M, Pallotta S. In phantom evaluation of targeting accuracy in MRI-based brain radiosurgery. Phys Med. 2021 May;85:158-164. doi: 10.1016/j.ejmp.2021.05.014. Epub 2021 May 17.
24. Piffer S, Casati M, Marrazzo L, Arilli C, Calusi S, Desideri I, Fusi F, Pallotta S, Talamonti C. Validation of a secondary dose check tool against Monte Carlo and analytical clinical dose calculation algorithms in VMAT. J Appl Clin Med Phys. 2021 Apr;22(4):52-62. doi: 10.1002/acm2.13209. Epub 2021 Mar 18.
25. Stick LB, Lorenzen EL, Yates ES, Anandadas C, Andersen K, Aristei C, Byrne O, Hol S, Jensen I, Kirby AM, Kirova YM, Marrazzo L, Matías-Pérez A, Nielsen MMB, Nissen HD, Oliveros S, Verhoeven K, Vikström J, Offersen BV. Selection criteria for early breast cancer patients in the DBCG proton trial - The randomised phase III trial strategy. Clin Transl Radiat Oncol. 2021 Feb 4;27:126-131. doi: 10.1016/j.ctro.2021.01.012. eCollection 2021 Mar.
26. Meattini I, Poortmans PM, Aznar MC, Becherini C, Bonzano E, Cardinale D, Lenihan DJ, Marrazzo L, Curigliano G, Livi L. Association of Breast Cancer Irradiation With Cardiac Toxic Effects: A Narrative Review. JAMA Oncol. 2021 Jun 1;7(6):924-932. doi: 10.1001/jamaoncol.2020.7468 
27. Casati M, Piffer S, Calusi S, Marrazzo L, Simontacchi G, Di Cataldo V, Greto D, Desideri I, Vernaleone M, Francolini G, Livi L, Pallotta S. Methodological approach to create an atlas using a commercial auto-contouring software. J Appl Clin Med Phys. 2020 Dec;21(12):219-230. doi: 10.1002/acm2.13093. Epub 2020 Nov 25.
28. Meattini I, Marrazzo L, Saieva C, Desideri I, Scotti V, Simontacchi G, Bonomo P, Greto D, Mangoni M, Scoccianti S, Lucidi S, Paoletti L, Fambrini M, Bernini M, Sanchez L, Orzalesi L, Nori J, Bianchi S, Pallotta S, Livi L. Accelerated Partial-Breast Irradiation Compared With Whole-Breast Irradiation for Early Breast Cancer: Long-Term Results of the Randomized Phase III APBI-IMRT-Florence Trial. J Clin Oncol. 2020 Dec 10;38(35):4175-4183. doi: 10.1200/JCO.20.00650. Epub 2020 Aug 24.
29. Meattini I, Poortmans PMP, Marrazzo L, Desideri I, Brain E, Hamaker M, et al. Exclusive endocrine therapy or partial breast irradiation for women aged ≥70  years with luminal A-like early stage breast cancer (NCT04134598 - EUROPA): Proof of concept of a randomized controlled trial comparing health related quality of life by patient reported outcome measures. J Geriatr Oncol. 2020 Jul 29:S1879-4068(20)30146-6. doi: 10.1016/j.jgo.2020.07.013. Online ahead of print.
30. Scoccianti S, Simontacchi G, Greto D, Perna M, Terziani F, Talamonti C, Teriaca MA, Caramia G, Lo Russo M, Olmetto E, Delli Paoli C, Grassi R, Carfora V, Saieva C, Bonomo P, Detti B, Mangoni M, Desideri I, Francolini G, Di Cataldo V, Marrazzo L, Pallotta S, Livi L. Dosimetric Predictors of Acute and Chronic Alopecia in Primary Brain Cancer Patients Treated With Volumetric Modulated Arc Therapy. Front Oncol. 2020 Apr 8;10:467. doi: 10.3389/fonc.2020.00467. eCollection 2020.
31. Marrazzo L, Arilli C, Pellegrini R, Bonomo P, Calusi S, Talamonti C, et al. Automated planning through robust templates and multicriterial optimization for lung VMAT SBRT of lung lesions. J Appl Clin Med Phys. 2020 Jun;21(6):114-120. doi: 10.1002/acm2.12872. Epub 2020 Apr 10.
32. Bonomo P, Talamonti C, Desideri I, Marrazzo L, Pezzulla D, Rampini A, et al. Analysis of skin dose distribution for the prediction of severe radiation dermatitis in head and neck squamous cell carcinoma patients treated with concurrent chemo-radiotherapy. Head Neck. 2020 Feb;42(2):244-253. doi: 10.1002/hed.25997. Epub 2019 Nov 4.
33. Pallotta S, Calusi S, Masi L, Talamonti C, Marrazzo L, Foggi L, et al. ADAM phantom to test 4D medical imaging and dose delivery devices. Phys Med Biol. IOP Publishing; 2019;64.
34. Calusi S, Labanca G, Zani M, Casati M, Marrazzo L, Noferini L, et al. A multiparametric method to assess the MIM deformable image registration algorithm. J Appl Clin Med Phys 2019:acm2.12564. doi:10.1002/acm2.12564 
35. Marrazzo L, Meattini I, Arilli C, Calusi S, Casati M, Talamonti C, et al. Auto-planning for VMAT accelerated partial breast irradiation. Radiother Oncol 2019;132:85–92. doi:10.1016/j.radonc.2018.11.006.
36. Zani M, Marrazzo L, Calusi S, Talamonti C, Scoccianti S, Greto D, et al. TomoTherapy treatments of multiple brain lesions: an in-phantom accuracy evaluation. Phys Med Biol 2018:0–22. doi:10.1088/1361-6560/aaf977.
37. Becherini C, Meattini I, Livi L, Garlatti P, Desideri I, Scotti V, Orzalesi L, Sanchez LJ, Bernini M, Casella D, Nesi S, Nori J, Bianchi S, Pallotta S, Marrazzo L. External accelerated partial breast irradiation for ductal carcinoma in situ: long-term follow-up from a phase 3 randomized trial. Tumori J 2018:030089161881127. doi:10.1177/0300891618811278.
38. Meattini I, Poortmans P, Livi L, Kaidar Person O, Pallotta S, Becherini C, et al. Partial breast irradiation for ductal carcinoma in situ: The Goldilocks principle? Breast J 2018;24:1118–9. doi:10.1111/tbj.13143.
39. Heijmen B, Voet P, Fransen D, Penninkhof J, Milder M, Akhiat H, et al. Fully automated, multi-criterial planning for Volumetric Modulated Arc Therapy – An international multi-center validation for prostate cancer. Radiother Oncol 2018. doi:10.1016/j.radonc.2018.06.023.
40. Bonomo P, Desideri I, Loi M, Mangoni M, Sottili M, Marrazzo L, et al. Anti PD-L1 DUrvalumab combined with Cetuximab and RadiOtherapy in locally advanced squamous cell carcinoma of the head and neck: A phase I/II study (DUCRO). Clin Transl Radiat Oncol 2018;9:42–7. doi:10.1016/j.ctro.2018.01.005.
41. Meattini I, Livi L, Pallotta S, Marrazzo L. Partial breast irradiation: The time is there! Breast 2018;38:98–100. doi:10.1016/j.breast.2017.12.014.
42. Marrazzo L, Arilli C, Pasler M, Kusters M, Canters R, Fedeli L, et al. Real-time beam monitoring for error detection in IMRT plans and impact on dose-volume histograms: A multi-center study. Strahlentherapie Und Onkol 2017;194:243–54. doi:10.1007/s00066-017-1245-3.
43. Calusi S, Noferini L, Marrazzo L, Casati M, Arilli C, Compagnucci A, et al. γTools: A modular multifunction phantom for quality assurance in GammaKnife treatments. Phys Medica 2017;43:34–42. doi:10.1016/j.ejmp.2017.10.010.
44. Scoccianti S, Krengli M, Marrazzo L, Magrini SM, Detti B, Fusco V, et al. Hypofractionated radiotherapy with simultaneous integrated boost (SIB) plus temozolomide in good prognosis patients with glioblastoma: a multicenter phase II study by the Brain Study Group of the Italian Association of Radiation Oncology (AIRO). Radiol Med 2017;123:48–62. doi:10.1007/s11547-017-0806-y.
45. Pallotta S, Calusi S, Foggi L, Lisci R, Masi L, Marrazzo L, et al. ADAM: A breathing phantom for lung SBRT quality assurance. Phys Medica 2017. doi:10.1016/j.ejmp.2017.07.004.
46. Pasler M, Michel K, Marrazzo L, Obenland M, Pallotta S, Björnsgard M, et al. Error detection capability of a novel transmission detector: A validation study for online VMAT monitoring. Phys Med Biol 2017;62:7440–50. doi:10.1088/1361-6560/aa7dc7.
47. Meattini I, Saieva C, Miccinesi G, Desideri I, Francolini G, Scotti V, et al. Accelerated partial breast irradiation using intensity modulated radiotherapy versus whole breast irradiation: Health-related quality of life final analysis from the Florence phase 3 trial. Eur J Cancer 2017;76:17–26. doi:10.1016/j.ejca.2017.01.023.
48. Schwarz M, Cattaneo GM, Marrazzo L. Geometrical and dosimetrical uncertainties in hypofractionated radiotherapy of the lung: A review. Phys Medica 2017;36:126–39. doi:10.1016/j.ejmp.2017.02.011.
49. Greto D, Pallotta S, Masi L, Talamonti C, Marrazzo L, Doro R, et al. A dosimetric comparison between CyberKnife and tomotherapy treatment plans for single brain metastasis. Radiol Medica 2017;122:392–7. doi:10.1007/s11547-017-0735-9.
50. Marrazzo L, Zani M, Pallotta S, Arilli C, Casati M, Compagnucci A, et al. GafChromic®EBT3 films for patient specific IMRT QA using a multichannel approach. Phys Medica 2015;31:1035–42. doi:10.1016/j.ejmp.2015.08.010.
51. Meattini I, Saieva C, Marrazzo L, Di Brina L, Pallotta S, Mangoni M, et al. Accelerated partial breast irradiation using intensity-modulated radiotherapy technique compared to whole breast irradiation for patients aged 70 years or older: subgroup analysis from a randomized phase 3 trial. Breast Cancer Res Treat 2015;153:539–47. doi:10.1007/s10549-015-3565-2.
52. Pallotta S, Vanzi E, Simontacchi G, Marrazzo L, Ceroti M, Paiar F, et al. Surface imaging, portal imaging, and skin marker set-up vs. CBCT for radiotherapy of the thorax and pelvis. Strahlentherapie Und Onkol 2015;191:726–33. doi:10.1007/s00066-015-0861-z.
53. Meattini I, Marrazzo L, Zani M, Paiar F, Pallotta S, Simontacchi G, et al. Four-dimensional computed tomography in accelerated partial breast irradiation planning: single series from a phase III trial. Radiol Medica 2015;120:1078–82. doi:10.1007/s11547-015-0541-1.
54. Livi L, Meattini I, Marrazzo L, Simontacchi G, Pallotta S, Saieva C, et al. Accelerated partial breast irradiation using intensity-modulated radiotherapy versus whole breast irradiation: 5-year survival analysis of a phase 3 randomised controlled trial. Eur J Cancer 2015;51:451–63. doi:10.1016/j.ejca.2014.12.013.
55. Marrazzo L, Zani M, Pallotta S, Greto D, Scoccianti S, Talamonti C, et al. Comparison of stereotactic plans for brain tumors with two different multileaf collimating systems. J Appl Clin Med Phys 2014;15:27–37. doi:10.1120/jacmp.v15i1.4100.
56. Scotti V, Marrazzo L, Saieva C, Agresti B, Meattini I, Desideri I, et al. Impact of a breathing-control system on target margins and normal-tissue sparing in the treatment of lung cancer: Experience at the radiotherapy unit of Florence University. Radiol Medica 2014;119:13–9. doi:10.1007/s11547-013-0307-6.
57. Franceschini D, Paiar F, Meattini I, Agresti B, Pasquetti EM, Greto D, et al. Simultaneous integrated boost-intensity-modulated radiotherapy in head and neck cancer. Laryngoscope 2013;123:97–103. doi:10.1002/lary.24257.
58. Bonomo P, Livi L, Rampini A, Meattini I, Agresti B, Simontacchi G, et al. Radioterapia stereotassica extracranica per metastasi cardiache e paracardiache: esperienza dell’Università di Firenze. Radiol Medica 2013;118:1055–65. doi:10.1007/s11547-013-0932-0.
59. Meattini I, Livi L, Franceschini D, Saieva C, Meacci F, Marrazzo L, et al. Role of radiotherapy boost in women with ductal carcinoma in situ: A single-center experience in a series of 389 patients. Eur J Surg Oncol 2013;39:613–8. doi:10.1016/j.ejso.2013.03.002.
60. Livi L, Meattini I, Franceschini D, Saieva C, Meacci F, Marrazzo L, et al. Radiotherapy boost dose-escalation for invasive breast cancer after breast-conserving surgery: 2093 Patients treated with a prospective margin-directed policy. Radiother Oncol 2013;108:273–8. doi:10.1016/j.radonc.2013.02.009.
61. Scoccianti S., Agresti B., Simontacchi G., Detti B., Cipressi S., Iannalfi A., Marrazzo L., Mangoni M., Paiar F., Livi L., Biti G. From a waiting list to a priority list: a computerized model for an easy-to-manage and automatically updated priority list in the booking of patients waiting for radiotherapy. Tumori, 98(6), 728-35, 2012.
62. Pallotta S, Simontacchi G, Marrazzo L, Ceroti M, Paiar F, Biti G, et al. Accuracy of a 3D laser/camera surface imaging system for setup verification of the pelvic and thoracic regions in radiotherapy treatments. Med Phys 2013;40. doi:10.1118/1.4769428.
63. Marrazzo L, Pallotta S, Kłosowski M, Czopyk, Bucciolini M, Olko P, et al. Clinical tests of large area thermoluminescent detectors under radiotherapy beams. Radiat Meas 2013;51–52:25–30. doi:10.1016/j.radmeas.2013.02.006.
64. Meattini I, Livi L, Saieva C, Franceschini D, Marrazzo L, Greto D, et al. Prognostic factors and clinical features in patients with leptominengeal metastases from breast cancer: a single center experience. J Chemother 2012;24:279–84. doi:10.1179/1973947812Y.0000000034.
65. Pallotta S, Marrazzo L, Ceroti M, Silli P, Bucciolini M. A phantom evaluation of Sentinel, a commercial laser/camera surface imaging system for patient setup verification in radiotherapy. Med Phys 2012;39:706–12. doi:10.1118/1.3675973.
66. Tonoli S, Vitali P, Scotti V, Bertoni F, Spiazzi L, Ghedi B, et al. Adjuvant radiotherapy after extrapleural pneumonectomy for mesothelioma. Prospective analysis of a multi-institutional series. Radiother Oncol 2011;101:311–5. doi:10.1016/j.radonc.2011.09.025.
67. Talamonti C, Bruzzi M, Marrazzo L, Menichelli D, Scaringella M, Bucciolini M. Bidimensional silicon dosimeter: Development and characterization. Nucl Instruments Methods Phys Res Sect A Accel Spectrometers, Detect Assoc Equip 2011;658:84–9. doi:10.1016/j.nima.2011.05.044.
68. Livi L, Meattini I, Scotti V, Saieva C, Simontacchi G, Marrazzo L, et al. Radio-chemioterapia concomitante con regimi a base dantracicline nel trattamento adiuvante del carcinoma mammario: Esperienza di un singolo centro. Radiol Medica 2011;116:1050–8. doi:10.1007/s11547-011-0652-2.
69. Scotti V, Meattini I, Saieva C, Agresti B, de Luca Cardillo C, Bastiani P, et al. Post-operative radiotherapy in N2 non-small cell lung cancer: A retrospective analysis of 175 patients. Radiother Oncol 2010;96:84–8. doi:10.1016/j.radonc.2010.05.010.
70. Livi L, Scotti V, Saieva C, Meattini I, Detti B, Simontacchi G, et al. Outcome After Conservative Surgery and Breast Irradiation in 5,717 Patients With Breast Cancer: Implications for Supraclavicular Nodal Irradiation. Int J Radiat Oncol Biol Phys 2010;76:978–83. doi:10.1016/j.ijrobp.2009.03.001. 
71. Livi L, Buonamici FB, Simontacchi G, Scotti V, Fambrini M, Compagnucci A, et al. Accelerated Partial Breast Irradiation With IMRT: New Technical Approach and Interim Analysis of Acute Toxicity in a Phase III Randomized Clinical Trial. Int J Radiat Oncol Biol Phys 2010;77:509–15. doi:10.1016/j.ijrobp.2009.04.070.
72. Livi L, Meattini I, Saieva C, Borghesi S, Scotti V, Petrucci A, et al. The impact of young age on breast cancer outcome. Eur J Surg Oncol 2010;36:639–45. doi:10.1016/j.ejso.2010.05.016.
73. Meattini I, Livi L, Saieva C, Marrazzo L, Rampini A, Iermano C, et al. Breast Cancer Following Hodgkin’s Disease: The Experience of the University of Florence. Breast J 2010;16:290–6. doi:10.1111/j.1524-4741.2010.00904.x.
74. Talamonti C, Reggioli V, Bruzzi M, Bucciolini M, Civinini C, Marrazzo L, et al. Proton radiography for clinical applications. Nucl Instruments Methods Phys Res Sect A Accel Spectrometers, Detect Assoc Equip 2010;612:571–5. doi:10.1016/j.nima.2009.08.040.
75. Sipala V, Bruzzi M, Bucciolini M, Candiano G, Capineri L, P. Cirrone GA, et al. A proton imaging device: Design and status of realization. Nucl Instruments Methods Phys Res Sect A Accel Spectrometers, Detect Assoc Equip 2010;612:566–70. doi:10.1016/j.nima.2009.08.029.
76. Civinini C, Brianzi M, Bruzzi M, Bucciolini M, Candiano G, Capineri L, et al. Towards a proton imaging system. Nucl Instruments Methods Phys Res Sect A Accel Spectrometers, Detect Assoc Equip 2010;623:588–90. doi:10.1016/j.nima.2010.03.079.
77. Menichelli D, Bruzzi M, Bucciolini M, Candiano G, Cirrone G, Capineri L, et al. Characterization of a silicon strip detector and a YaG: Ce calorimeter for a proton computed radiography apparatus. Nucl Sci IEEE Trans 2010;57:8–16.
78. Livi L, Borghesi S, Saieva C, Meattini I, Rampini A, Petrucci A, et al. Radiotherapy Timing in 4,820 Patients With Breast Cancer: University of Florence Experience. Int J Radiat Oncol Biol Phys 2009;73:365–9. doi:10.1016/j.ijrobp.2008.04.066.
79. Sipala V, Bruzzi M, Bucciolini M, Candiano G, Capineri L, Cirrone GAP, et al. First Results and Realization Status of a Proton Computed Radiography Device. Nucl Phys B - Proc Suppl 2009;197:39–42. doi:10.1016/j.nuclphysbps.2009.10.030.
80. Talamonti C, Bucciolini M, Marrazzo L, Menichelli D, Bruzzi M, Cirrone GAP, et al. Dosimetric characterization with 62 MeV protons of a silicon-segmented detector for 2D dose verifications in radiotherapy. Nucl Instruments Methods Phys Res Sect A Accel Spectrometers, Detect Assoc Equip 2008;596:126–30. doi:10.1016/j.nima.2008.07.134.
81. Banci Buonamici F, Compagnucci A, Marrazzo L, Russo S, Bucciolini M. An intercomparison between film dosimetry and diode matrix for IMRT quality assurance. Med Phys 2007;34:1372–9. doi:10.1118/1.2713426.
82. Pallotta S, Marrazzo L, Bucciolini M. Design and implementation of a water phantom for IMRT, arc therapy, and tomotherapy dose distribution measurements. Med Phys 2007;34:3724–31. doi:10.1118/1.2776249.
83. Talamonti C, Bruzzi M, Bucciolini M, Marrazzo L, Menichelli D. Preliminary dosimetric characterization of a silicon segmented detector for 2D dose verifications in radiotherapy. Nucl Instruments Methods Phys Res Sect A Accel Spectrometers, Detect Assoc Equip 2007;583:114–8. doi:10.1016/j.nima.2007.08.225.
84. Menichelli D, Bruzzi M, Bucciolini M, Talamonti C, Casati M, Marrazzo L, et al. Design and development of a silicon-segmented detector for 2D dose measurements in radiotherapy. Nucl Instruments Methods Phys Res Sect A Accel Spectrometers, Detect Assoc Equip 2007;583:109–13. doi:10.1016/j.nima.2007.08.209.