Michele SORELLI

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Michele SORELLI

Orario di ricevimento (aggiornato al 26/02/2024)

Martedì, 16:00 - 17:00

Michele SORELLI

Pubblicazioni

Legenda

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Articolo su libro |

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Tesi di Dottorato

Pini E.; Meo D.D.; Costantini I.; Sorelli M.; Gatto A.; Schafer H.; Pavone F.S.; Wiersma D.S.; Pattelli L. (2025). Experimental evidence for anisotropic diffusion of light in white matter tissue. PROGRESS IN BIOMEDICAL OPTICS AND IMAGING, vol. 13314, pp. 0-0, ISSN:1605-7422 DOI

Costantini I.; Sorelli M.; DI Meo D.; Bradley S.; Ramazzotti J.; Lorenzon B.; Cheli F.; Perego L.; Mazzamuto G.; Checcucci C.; Frasconi P.; Pavone F.S. (2025). Cyto- and myeloarchitectonics characterization of human cortex and brainstem with light sheet fluorescence microscopy. In: Neural Imaging and Sensing 2025, usa, 2025, SPIE, vol. 13303, pp. 0-0. DOI

Costantini I.; Di Meo D.; Ramazzotti J.; Cheli F.; Sorelli M.; Mazzamuto G.; Checcucci C.; Frasconi P.; Pavone F.S. (2024). Light-sheet fluorescence microscopy for 3D reconstruction of human brain. In: Optics and the Brain, BRAIN 2024 - Part of Optica Biophotonics Congress: Biomedical Optics, usa, 2024, Optical Society of America, pp. 0-0. DOI

Turrini L.; Sorelli M.; de Vito G.; Vanzi F.; Pavone F.S. (2024). Dissecting Zebrafish Brain Functional Connectivity with Two-photon All-optical Electrophysiology. In: Optica Biophotonics Congress: Biomedical Optics 2024 (Translational, Microscopy, OCT, OTS, BRAIN), Fort Lauderdale, Florida United States, 7–10 April 2024, Optica Publishing Group, 2024, vol. Technical Digest Series, pp. 0-0, ISBN:978-1-957171-34-0 DOI Accesso ONLINE all'editore

Turrini, Lapo; Ricci, Pietro; Sorelli, Michele; de Vito, Giuseppe; Marchetti, Marco; Vanzi, Francesco; Pavone, Francesco Saverio (2024). Two-photon all-optical neurophysiology for the dissection of larval zebrafish brain functional and effective connectivity. COMMUNICATIONS BIOLOGY, vol. 7, pp. 0-0, ISSN:2399-3642 DOI Accesso ONLINE all'editore

Turrini, Lapo; Ricci, Pietro; de Vito, Giuseppe; Sorelli, Michele; Marchetti, Marco; Vanzi, Francesco; Silvestri, Ludovico; Pavone, Francesco Saverio (2023). Fast multi-photon brain-wide volumetric imaging and photostimulation. In: SPIE BiOS, San Francisco, California, United States, 28 January - 3 February 2023, SPIE, vol. 12384, pp. 0-0, ISBN:9781510658738 DOI Accesso ONLINE all'editore

Sorelli, Michele; Costantini, Irene; Bocchi, Leonardo; Axer, Markus; Pavone, Francesco Saverio; Mazzamuto, Giacomo (2023). Fiber enhancement and 3D orientation analysis in label-free two-photon fluorescence microscopy. SCIENTIFIC REPORTS, vol. 13, pp. 4160-4160, ISSN:2045-2322 DOI

Lapo Turrini , Michele Sorelli, Giuseppe de Vito , Caterina Credi , Natascia Tiso , Francesco Vanzi , Francesco Saverio Pavone (2022). Multimodal Characterization of Seizures in Zebrafish Larvae. BIOMEDICINES, vol. 10, pp. 951-951, ISSN:2227-9059 DOI Accesso ONLINE all'editore

Ricci, Pietro; Marchetti, Marco; Sorelli, Michele; Turrini, Lapo; Resta, Francesco; Gavryusev, Vladislav; de Vito, Giuseppe; Sancataldo, Giuseppe; Vanzi, Francesco; Silvestri, Ludovico; Pavone, Francesco Saverio (2022). Power-effective scanning with AODs for 3D optogenetic applications. JOURNAL OF BIOPHOTONICS, vol. 15, pp. 0-0, ISSN:1864-063X DOI Accesso ONLINE all'editore

Pietro Ricci, Marco Marchetti, Michele Sorelli, Lapo Turrini, Francesco Resta, Vladislav Gavryusev, Giuseppe de Vito, Giuseppe Sancataldo, Francesco Vanzi, Ludovico Silvestri, Francesco Saverio Pavone (2022). An AOD breakthrough for volumetric 2P optogenetic applications. In: SPIE Photonics Europe, 2022, Strasbourg, France, 3 - 7 April 2022, SPIE, vol. PC12144, pp. 0-0. DOI Accesso ONLINE all'editore

Sorelli, Michele; Hutson, T. Noah; Iasemidis, Leonidas; Bocchi, Leonardo (2022). Linear and Nonlinear Directed Connectivity Analysis of the Cardio-Respiratory System in Type 1 Diabetes. FRONTIERS IN NETWORK PHYSIOLOGY, vol. 2, pp. 840829-840829, ISSN:2674-0109 DOI

Morelli A.; Sorelli M.; Francia P.; Bocchi L. (2021). Modelling of Microcirculatory Dynamics with Auto-regressive Models. In: 8th European Medical and Biological Engineering Conference, EMBEC 2020, svn, 2020, Springer Science and Business Media Deutschland GmbH, vol. 80, pp. 824-832, ISBN:978-3-030-64609-7 DOI

Costantini, Irene; Baria, Enrico; Sorelli, Michele; Matuschke, Felix; Giardini, Francesco; Menzel, Miriam; Mazzamuto, Giacomo; Silvestri, Ludovico; Cicchi, Riccardo; Amunts, Katrin; Axer, Markus; Pavone, Francesco Saverio (2021). Autofluorescence enhancement for label-free imaging of myelinated fibers in mammalian brains. SCIENTIFIC REPORTS, vol. 11, pp. 0-0, ISSN:2045-2322 DOI Accesso ONLINE all'editore

Tarchi P.; Bologna F.; Scortecci C.; Tiribilli E.; Pennati D.; Sacconi L.; Sorelli M.; Bocchi L. (2020). Modeling of voltage imaging for the study of action potential propagation. In: International Conference on Medical and Biological Engineering in Bosnia and Herzegovina, CMBEBIH 2019, bih, 2019, Springer Verlag, vol. 73, pp. 309-314, ISBN:978-3-030-17970-0 DOI Accesso ONLINE all'editore

Sorelli M.; Bocchi L. (2020). Analysis of myogenic and respiratory oscillatory components in laser Doppler flowmetry pulse waveforms. In: 11th Conference of the European Study Group on Cardiovascular Oscillations, ESGCO 2020, ita, 2020, Institute of Electrical and Electronics Engineers Inc., pp. 1-2, ISBN:978-1-7281-5751-1 DOI

Fleischhauer V.; Ruprecht N.; Sorelli M.; Bocchi L.; Zaunseder S. (2020). Pulse decomposition analysis in photoplethysmography imaging. PHYSIOLOGICAL MEASUREMENT, vol. 41, pp. 095009-095009, ISSN:0967-3334 DOI

Sorelli, Michele; Perrella, Antonia; Francia, Piergiorgio; Bocchi, Leonardo (2020). Wavelet Phase Coherence Analysis Between the Respiratory Activity and the Microcirculation: The Effects of Type 1 Diabetes. In: International Conference on Medical and Biological Engineering in Bosnia and Herzegovina, CMBEBIH 2019;, Springer, Cham, pp. 61-65, ISBN:978-3-030-17970-0 DOI

Iadanza, Ernesto; Goretti, Francesco; Sorelli, Michele; Melillo, Paolo; Pecchia, Leandro; Simonelli, Francesca; Gherardelli, Monica (2020). Automatic Detection of Genetic Diseases in Pediatric Age Using Pupillometry. IEEE ACCESS, vol. 8, pp. 34949-34961, ISSN:2169-3536 DOI Accesso ONLINE all'editore

Felici A.; Sorelli M.; Bocchi L. (2020). Design and implementation of a monitoring system for elastomeric infusion pumps. In: International Conference on Medical and Biological Engineering in Bosnia and Herzegovina, CMBEBIH 2019, bih, 2019, Springer Verlag, vol. 73, pp. 201-204, ISBN:978-3-030-17970-0 DOI Accesso ONLINE all'editore

Sorelli M.; Kopietz C.; Zaunseder S.; Bocchi L. (2019). Pulse decomposition analysis in camera-based photoplethysmography. In: 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019, deu, 2019, Institute of Electrical and Electronics Engineers Inc., vol. 2019, pp. 3179-3182, ISBN:978-1-5386-1311-5 DOI

Michele Sorelli (2019). Quantitative analysis of microvascular oscillations and their alterations. (Tutor: Leonardo Bocchi)

Sorelli, Michele; Perrella, Antonia; Francia, Piergiorgio; De Bellis, Alessandra; Anichini, Roberto; Bocchi, Leonardo (2019). Multi-gaussian Decomposition of the Microvascular Pulse Detects Alterations in Type 1 Diabetes. In: World Congress on Medical Physics and Biomedical Engineering, WC 2018, Springer Singapore, pp. 173-176, ISBN:978-981-10-9022-6 DOI

piergiorgio francia, michele sorelli, barbara piccini, giulia iannone, laura capirchio, sonia toni, massimo gulisano, leonardo bocchi (2019). Glycemic controlmaintained over time and joint stiffness in young type 1 patients: whats is the mathematical relationship?. JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY, pp. 1-6, ISSN:1932-2968 DOI

Sorelli, Michele; Francia, Piergiorgio; Bocchi, Leonardo; De Bellis, Alessandra; Anichini, Roberto (2019). Assessment of cutaneous microcirculation by laser Doppler flowmetry in type 1 diabetes. MICROVASCULAR RESEARCH, vol. 124, pp. 91-96, ISSN:0026-2862, ACADEMIC PRESS INC ELSEVIER SCIENCE: 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA DOI

Lapo Pierguidi, Andrea Guazzini, Enrico Imbimbo, Stefania Righi, Michele Sorelli, Leonardo Bocchi (2019). Validation of a low-cost EEG device in detecting neural correlates of social conformity. In: 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Berlin, 23-27 Luglio 2019, IEEE, pp. 0-0. DOI Accesso ONLINE all'editore

Sorelli, Michele; Perrella, Antonia; Bocchi, Leonardo (2018). Modeling of the microvascular pulse for tracking the vasoconstriction response to deep inspiratory gasp. In: World Congress on Medical Physics and Biomedical Engineering, WC 2018, cze, 2018, Springer Verlag, vol. 68, pp. 307-310, ISBN:978-981-10-9037-0 DOI Accesso ONLINE all'editore

Francia Piergiorgio, Ugo Santosuosso, Michele Sorelli, Leonardo Bocchi (2018). Andamento distale prossimale delle modificazioni posturali della mano e del piede in giovani pazienti con diabete di tipo 1. In: Congresso della Diabetologia Toscana Nodi e intrecci di una rete: evidenze scientifiche ed esperienze a confronto, Grosseto, 30 novembre - 1 dicembre 2018, Bonomia University Press, vol. 30, pp. 1-1.

Perrella, Antonia; Sorelli, Michele; Giardini, Francesco; Frassineti, Lorenzo; Francia, Piergiorgio; Bocchi, Leonardo (2018). Wavelet Phase Coherence Between the Microvascular Pulse Contour and the Respiratory Activity. In: World Congress on Medical Physics and Biomedical Engineering 2018, Springer Singapore, pp. 1-1, ISBN:978-981-10-9037-0 DOI

Michele Sorelli*, Antonia Perrella, Leonardo Bocchi, (2018). Detecting vascular age using the analysis of peripheral pulse. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, vol. -, pp. 1-1, ISSN:0018-9294 DOI Accesso ONLINE all'editore

P. Francia, Laura Capirchio, Ugo Santosuosso, Michele Sorelli, Barbara Piccini, Alessandro Vittori, Giulia Iannone, M. Gulisano, S. Toni (2018). The effects of type 1 diabetes on hand and foot posture and mobility of young patients. DIABETOLOGIA, pp. 535-536, ISSN:0012-186X

Alexandre Lima; Tom van Rooij; Bulent Ergin; Michele Sorelli; Yasin Ince; Patricia A. C. Specht; Egbert G. Mik; Leonardo Bocchi; Klazina Kooiman; Nico de Jong; Can Ince (2018). Dynamic Contrast-Enhanced Ultrasound Identifies Microcirculatory Alterations in Sepsis-Induced Acute Kidney Injury. CRITICAL CARE MEDICINE, vol. 46, pp. 1284-1292, ISSN:0090-3493 DOI

PERRELLA, ANTONIA; SORELLI, MICHELE; FRANCIA, PIERGIORGIO; CAPIRCHIO, LAURA; ANICHINI, ROBERTO; BELLIS, ALESSANDRA DE; GULISANO, MASSIMO; BOCCHI, LEONARDO (2018). Wavelet Phase Coherence Analysis between the Respiratory Activity and the Microcirculation—The Effects of Type 1 Diabetes. DIABETES, vol. 67, pp. 451-451, ISSN:0012-1797 DOI

Piergiorgio Francia, Francesca Barbagallo, Michele Sorelli, Giulia Iannone, Ugo Santosuosso, Massimo Gulisano (2018). The consequences of interrupting adapted physical activity program on a population of elderly subjects.. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, pp. 94-94, ISSN:1122-6714

Sorelli, Michele; Ince, Can; Bocchi, Leonardo (2017). Particle tracking for the assessment of microcirculatory perfusion. PHYSIOLOGICAL MEASUREMENT, vol. 38, pp. 358-373, ISSN:0967-3334 DOI Accesso ONLINE all'editore

Sorelli, Michele; Perrella, Antonia; Bocchi, Leonardo (2017). Cardiac pulse waves modeling and analysis in laser doppler perfusion signals of the skin microcirculation. In: International Conference on Medical and Biological Engineering, CMBEBIH 2017, 2017, Springer Verlag, vol. 62, pp. 20-25, ISBN:9789811041655 DOI Accesso ONLINE all'editore

Frassineti, Lorenzo; Giardini, Francesco; Perrella, Antonia; Sorelli, Michele; Sacconi, Leonardo; Bocchi, Leonardo (2017). Evaluation of spatial distribution of skin blood flow using optical imaging. In: International Conference on Medical and Biological Engineering, CMBEBIH 2017, 2017, Springer Verlag, vol. 62, pp. 74-80, ISBN:9789811041655 DOI Accesso ONLINE all'editore

Sorelli, Michele; Stoyneva, Zlatka; Mizeva, Irina; Bocchi, Leonardo (2017). Spatial heterogeneity in the time and frequency properties of skin perfusion. PHYSIOLOGICAL MEASUREMENT, vol. 38, pp. 860-876, ISSN:0967-3334 DOI Accesso ONLINE all'editore

Francia, Piergiorgio; Perrella, Antonia; Sorelli, Michele; Toni, Sonia; Piccini, Barbara; Sardina, Gabriella; Gulisano, Massimo; Bocchi, Leonardo (2017). A mathematical model of the effect of metabolic control on joint mobility in young type 1 diabetic subjects. In: International Conference on Medical and Biological Engineering, CMBEBIH 2017, 2017, Springer Verlag, vol. 62, pp. 355-359, ISBN:9789811041655 DOI Accesso ONLINE all'editore

Sorelli, Michele; Bocchi, Leonardo; Stoyneva, Zlatka; Mizeva, Irina (2016). Location-dependent microvascular response to thermal stimulation. In: International Conference on Biological Oscillations, Lancaster, Lancaster university, pp. 178-179. Accesso ONLINE all'editore

Sorelli, M.; Cantasano, L.; Rasero, L.; Bocchi, L. (2016). Objective assessment of the Manual Lymph Drainage technique in chronic leg ulceration. In: Congresso GNB 2016, -, pp. 0-0.

Sorelli, M.; Cantasano, L.; Bocchi, L.; Guazzini, A.; Rasero, L.; Bartoloni, A. (2016). Assessment of manual lymph drainage in chronic leg ulcers. In: WUWH, firenze, JWC, pp. 481-481. Accesso ONLINE all'editore

Sorelli, M.; Bocchi, L.; Ince, C. (2015). Monitoring the microcirculation at the bedside using hand-held imaging microscopes: Automatic tracking of erythrocytes. In: 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015, MiCo Center, Milano Congressi Center, ita, 2015, Institute of Electrical and Electronics Engineers Inc., vol. 2015-, pp. 7378-7381, ISBN:9781424492718 DOI

Michele SORELLI

Biography

Michele Sorelli received his master’s degree in Biomedical Engineering from UniFI in 2015, with a final thesis on image processing techniques for monitoring the microvascular functionality in critical care scenarios, developed at the Erasmus Medical Center in Rotterdam.
In 2018, he completed a PhD at UniFI where he investigated advanced methods for the noninvasive diagnosis of microcirculatory alterations.
Since 2019, he has been working as post-doctoral researcher at the European Laboratory for Non-linear Spectroscopy (LENS) within the biophysics group led by Prof. Francesco Pavone. His current research activities mainly focus on the realization of ultra-fast control systems for the in-vivo optogenetic manipulation of neuronal circuit dynamics, the implementation of machine-learning based image processing pipelines for quantitative volumetric microscopy and, furthermore, the development of virtual reality systems for the investigation of visually evoked neuronal activity patterns and behaviors in zebrafish larvae.

Michele SORELLI

Curriculum

RESEARCH EXPERIENCE
Dates (from – to)	September 2019 – present:	Post-doctoral researcher at the European Laboratory for Non-linear Spectroscopy (LENS) and the Department of Physics and Astronomy of the University of Florence Acquisition of fluorescence microscopy image reconstructions of brain tissue samples. Design and development of an image processing pipeline for quantitative analysis of the brain structural connectivity from volumetric fluorescence microscopy images. 3D fiber orientation analysis from two-photon laser scanning fluorescence microscopy images. Machine learning-based neuronal cell image enhancement and detection from light-sheet fluorescence microscopy images. Design and implementation of an ultra-fast control system for the 3D multi-site random access photostimulation of neuronal circuit dynamics using acousto-optic deflectors. Development of a virtual reality for the investigation of visually-evoked neuronal activity patterns and behaviors in zebrafish larvae.
	December 2018 - August 2019:	Research fellow at the Department of Information Engineering of the University of Florence Acquisition of Laser Doppler Flowmetry signals of cutaneous blood perfusion from diabetic patients. Linear and non-linear directed connectivity analysis of the cardio-respiratory system in type 1 diabetes. Statistical analysis of experimental data.
	February 2015 - September 2015:	Research assistant at the Department of Intensive Care of the Erasmus University Medical Center in Rotterdam (Rotterdam, NL) Acquisition of microvascular perfusion images using Laser Speckle Contrast Imaging systems and handheld incident dark field video microscopes. Microvascular bioimage processing and quantitative analysis. Statistical analysis of experimental data.
EDUCATION AND TRAINING
Dates (from – to)	November 2015 - April 2019:	Doctor of Philosophy in Information Engineering at the University of Florence Title: "Quantitative analysis of microvascular oscillations and their alterations" Tutor: Prof. Leonardo Bocchi
	December 2011- April 2015:	Master’s Degree in Biomedical Engineering at the University of Florence Title: "Automated methods for the assessment of microcirculatory perfusion and density" Tutors: Prof. Leonardo Bocchi, Prof. Dr. Can Ince, Ing. Maurizio Baroni Grade: 110/110 cum laude
	September 2014 - April 2015:	Erasmus+ Traineeship Programme at the Department of Intensive Care of the Erasmus University Medical Center in Rotterdam (Rotterdam, NL) Comparative study of state-of-the-art software tools for the automatic noninvasive analysis of the microcirculation in critical care scenarios. Implementation of computer vision algorithms for the automatic estimation of capillary flow velocities in videos acquired using the handheld CytoCam incident dark field microscope (Braedius Medical, NL).
	February 2012 - July 2012:	Erasmus Study Programme at the Technische Universiteit Delft (Delft, NL) Courses and exams: Bio-inspired design, Biomaterials, Biomaterials mini-research project, Medical Imaging, Medical Instruments.
	September 2008 - December 2011:	Bachelor’s Degree in Electronics and Telecommunications Engineering at the University of Florence Title: "Deterministic chaos: bioengineering applications" Tutor: Prof. Claudia Manfredi Grade: 110/110 cum laude (with spetial mention for the academic curriculum)

RESEARCH ACTIVITIES

Research sectors

Biomedical Image and Signal Processing, Brain Functional and Structural Connectivity, Fluorescence Microscopy, Machine Learning, Network Physiology, Optogenetics

Projects funded in the last 5 years	Role	Funding body
3D Autonomous 2-PhoTon Optogenetics MICroscopy	Team member	European Research Council
Human Brain Optical Mapping	Team member	Fondazione Cassa di Risparmio di Firenze
Human Brain Project (SGA2) Human Brain Project (SGA3)	Team member	EU Horizon 2020
3D Random Access 2-Photon Optogenetics	Team member	EU Horizon 2020
Modelling of microvascular alterations	Team member	Fondazione Cassa di Risparmio di Firenze
Contrast Enhanced Ultrasound Echo and Hand-Held Vital Microscopy for bedside imaging of early microcirculatory alterations associated with the development of acute kidney injury: a validation study	Team Member	Dutch Kidney Foundation

Michele SORELLI

Interest

Biomedical Image and Signal Processing
Brain Functional and Structural Connectivity
Machine Learning
Network Physiology
Optogenetics
Quantitative Microscopy